CN105595224A - Sea cucumber dunaliella salina glucosan selenium preparation and preparation process - Google Patents
Sea cucumber dunaliella salina glucosan selenium preparation and preparation process Download PDFInfo
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- CN105595224A CN105595224A CN201511015723.XA CN201511015723A CN105595224A CN 105595224 A CN105595224 A CN 105595224A CN 201511015723 A CN201511015723 A CN 201511015723A CN 105595224 A CN105595224 A CN 105595224A
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- sea cucumber
- salt algae
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- carragheen
- selenide
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to the technical field of traditional Chinese medicinal health-care products, in particular to a sea cucumber dunaliella salina glucosan selenium preparation and a preparation process. The sea cucumber dunaliella salina glucosan selenium preparation is characterized by being prepared from the following components in parts by weight: 40 to 45 parts of sea cucumber, 20 to 40 parts of dunaliella salina, 15 to 40 parts of yeast glucan and 0.01 to 0.05 part of selenium carrageenan. The sea cucumber dunaliella salina glucosan selenium preparation has the advantages of enhancing the immunity and the constitution of a human body, improving the memory and the like.
Description
Technical field
The present invention relates to traditional Chinese medicine health care product technical field, specifically a kind of sea cucumber salt algae glucan selenium preparation and preparation technology who strengthens body immunity, enhancing human body constitution, improves memory.
Background technology
Along with socioeconomic development, people's growth in the living standard, people are increasing to the attention degree of self health, but, due to the quickening of work rhythm, the increase of operating pressure, and the minimizing of motion, people's immunity is generally low, immunity is the defense mechanism of human body self, human body identification and any material of eliminating external intrusion, process old and feeble, damage, dead, self cell of sex change and the ability of identification and processing vivo mutations cell and virus infected cell, the health of hypoimmunity is easy to infected or cancer stricken, immunity overlength also can produce infringement to health, as allergic reaction, autoimmunity disease etc., a variety of causes makes immune system can not normally bring into play protective effect, in the case, very easily cause bacterium, virus, the infection such as fungi, therefore the most directly performance of hypoimmunity is exactly liable to illness, along with the increase at age, failure of memory also can cause very large inconvenience to life.
Summary of the invention
The object of the invention is to solve above-mentioned the deficiencies in the prior art, a kind of sea cucumber salt algae glucan selenium preparation and preparation technology who strengthens body immunity, enhancing human body constitution, improves memory is provided.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of sea cucumber salt algae glucan selenium preparation, it is characterized in that said preparation is made up of sea cucumber, salt algae element, yeast dextran and selenide of carragheen, wherein each components by weight of sea cucumber, salt algae element, yeast dextran and selenide of carragheen is: 40 ~ 45 parts of sea cucumbers, 20 ~ 40 parts of salt algae elements, 15 ~ 40 parts of yeast dextrans, 0.01 ~ 0.05 part of selenide of carragheen.
A preparation technology for sea cucumber salt algae glucan selenium preparation, is characterized in that making step is as follows:
(1): first fresh sea cucumber is cleaned, cut off, remove internal organ, retain the liquid of the enzyme that contains sea cucumber self-dissolving flowing out, and by the impurity Ex-all in the sea cucumber intestine in sea cucumber internal organ and sea cucumber, sea cucumber intestine and sea cucumber are for subsequent use in the lump, then by sea cucumber, the broken rear ball milling making beating of sea cucumber intestine and sea cucumber pollen, add in enzymatic vessel, add again the water of 5 ~ 10 times of sea cucumber raw material, add again liquid and the appropriate food flavor enzyme of the enzyme that contains sea cucumber self-dissolving of reservation, mix, open steam cock, gradually be warming up to 45 ~ 65 DEG C, under the condition constantly stirring, maintain constant temperature 3.5 ~ 4 hours, treating that whole liquid is clarified is substantially warming up to 100 DEG C, after 5 ~ 10 minutes, cooling is filtered, it is 2% ~ 10% that gained supernatant liquid is adjusted to concentration, then spray with the dry tower of clean spray dry, the spray powder of gained after the assay was approved, polybag vacuumizes packaging, low temperature is preserved, for subsequent use,
(2): by the salt algae element of buying on market, send inspection center inspection, test rating is all qualified, then by after dry salt algae element processing, put into clean stainless steel pulverizing machine and pulverize, then cross 100 eye mesh screens, by for subsequent use after gained powder-tight packaging;
(3): get yeast dextran, send inspection center inspection, yeast dextran amount >=70%, protein≤3.5%, fat≤10%, moisture≤8%, ash content≤3%, index are all qualified, yeast dextran being put into clean stainless steel pulverizing machine pulverizes again, then cross 100 eye mesh screens, by for subsequent use after gained powder-tight packaging;
(4): get selenide of carragheen, send inspection center inspection, k-selenocarrageenan content >=2.0%, moisture≤6% qualified, then selenide of carragheen is put into clean stainless steel pulverizing machine and pulverize, then cross 100 eye mesh screens, by for subsequent use after gained powder-tight packaging;
(5): be 40 ~ 45 parts of sea cucumbers by the sea cucumber powder being up to the standards, salt algae element, yeast dextran and selenide of carragheen according to weight ratio, 20 ~ 40 parts of salt algae elements, 15 ~ 40 parts of yeast dextrans, 0.01 ~ 0.05 part of selenide of carragheen, be placed in three-dimensional mixer start and mix 20 minutes, mix;
(6): according to granulating process, with 65 ~ 70% alcohol granulations, at 80 ~ 90 degree temperature, be dried, then carry out whole grain according to particle situation.
After whole grain of the present invention, fill encapsulated according to production technology, in the qualified workshop of GMP, with after automatic capsule agent loading amount commissioning device according to the rules, encapsulated according to technique start, in loading amount process, check at any time product, product qualified loading amount is polished in sanding machine, after large packaging, it is to be tested qualified to move between temporary, send make-up room to pack, product again after the assay was approved, then according to technological order require pack, inner packing completes in clean area, and external packing completes in normal areas.
After whole grain of the present invention according to the agent of technological process of production granulation, capsule preparations or chewable tablets.
Constituent analysis of the present invention
Sea cucumber, sea cucumber, is one of seafood delights " eight delicacies ", equally celebrated for their achievements with bird's nest, abalone, shark's fin, cold nature, taste is sweet, salty, returns lung, kidney, large intestine channel, has the effect such as tonifying kidney and benefiting sperm, enriching the blood to restore normal menstruation, is medically usually used in curing mainly essence and blood loss, weak labor is timid, impotence, nocturnal emission, the dry constipation of intestines, cough due to deficiency of the lung, spitting of blood, hematochezia, traumatism and bleeding etc., have " jinxs of all kinds of diseases and ailments ", " god of longevity ", " first of hundred benefits ", good reputations such as " god who enriches blood ", it is high protein nourishing food, sea cucumber mainly contain protein, polypeptide, holothurin, mucopolysaccharide, the multiple nutritional components such as lipid, there is the antitumor action of wide spectrum, inhibition cancer cell grow in transfer, to the growth of malignant tumour, transfer has remarkable inhibitory action, there is anti-inflammatory, osteogenic action, to hepatitis, tuberculosis, diabetes, angiocardiopathy has significant therapeutic effect, medicinal health value is high.
Salt algae element, is the unicellular organism having survived on earth 3,800,000,000 years, and the earth experiences five secondary pollutant mass extinctions, the biology of unique survival, is also life blank the earliest, contains more than 90 kind of biological element, salt algae biological element, contain unique DNA repair function, the cell that runs into damage can be repaired very soon, salt algae nutrient, the ratio of content and the body fluid of human body, the anastomose property of cell slurries, can directly act on human body cell, contains abundant fat-soluble A linoleic acid, lecithin, folic acid, vitamin E, polysaccharide from Dunaliella salina, dietary fiber, phosphorus, potassium, iron, zinc, iodine, the mineral trace element needing Deng more than 70 kinds of human bodies is also contained in lysine, tryptophan, phenylalanine, methionine, threonine, isoleucine, Deng 18 gynaminic acid, International Union of Nutritional Science " international nutrition federation communication " (Iunsewslet--ter) in salt algae and the each large tonic in the world done comparative analysis, comprising the Cordyceps sinensis of China Qinghai-Tibet Platean, find first of salt algae and each large tonic, with regard to nutritional labeling, salt algae is more tens kinds than Cordyceps sinensis, and nutrition grow composition salt algae than Cordyceps sinensis height tens times (select from BOE chief editor " extreme biological bring the extreme life-span for the mankind " book 04-09 page), the uniqueness of salt algae element is the body fluid of its nutrient content ratio and human body, cytoplasm liquid phase is coincide, and is described as in " cell mobility source " by biomedical boundary, " protective agent of life ", salt algae element can be known free radical, regulate acid-base balance, supplement cell nutritious element comprehensively, repair sugar chain.
Yeast dextran, claim again dextran, for a kind of polysaccharide, be present in the mucus that certain micro-organisms secretes in growth course, be described as " super glossy ganoderma ", " directed detoxicating, immunity pioneer ", " person of chasing of virocyte " and " hope that tumor patient is last " etc., there is the immunity of enhancing, radioresistance, regulate the effect of blood fat, main pharmacological property has enhancing human immune system, quick adjustment immunity, the free radical of removing, activating macrophage, biting the removings such as neutrophil cell causes cell to decompose fragment by radiation, can make macrophage distinguish and destroy mutant, assist damaged tissues to produce cytokine (IL-1) as lymphocyte adds quick-recovery, impel and comprise antibiotic, antimycotic, anti-parasitic medicine is played effectiveness better at interior other drug, lower the low density fat in blood, improve high density fat, reduce the generation of high fat of blood, suppress tumour, anti-oxidant, radiation effects, help the regeneration of bodily tissue structure and repair, promote wound healing, relax bowel, regulate gastrointestinal function, reduce cholesterol.
Selenide of carragheen, it is the trace element of needed by human, it is exactly liver that human body includes the abundantest organ of selenide of carragheen amount, can reduce the injury of noxious material to liver and help liver detoxification, the toxic action of antagonism and reduction various heavy, can protect lung, liver, multiple organs such as heart and eyes, have anti-oxidant, improve immunity, delay senility, strengthen the functions such as fecundity, can strengthen the activity that is distributed in the glutathione peroxidase in liver cell liquid and mitochondria, remove free radical and MDA, accelerate the improvement of liver function and cross liver-protective object, selenium element can effectively be removed free radical, cardioprotection, control cardio cerebrovascular affection.
The present invention, owing to adopting above-mentioned composition preparation, has the body immunity of enhancing, strengthens human body constitution, improves the advantages such as memory, B.
Detailed description of the invention
A kind of sea cucumber salt algae glucan selenium preparation, it is characterized in that said preparation is by sea cucumber, salt algae element, yeast dextran and selenide of carragheen composition, wherein sea cucumber, salt algae element, each components by weight of yeast dextran and selenide of carragheen is: 40 ~ 45 parts of sea cucumbers, 20 ~ 40 parts of salt algae elements, 15 ~ 40 parts of yeast dextrans, 0.01 ~ 0.05 part of selenide of carragheen, making step is as follows: first fresh sea cucumber is cleaned, cut off, remove internal organ, retain the liquid of the enzyme that contains sea cucumber self-dissolving flowing out, and by the impurity Ex-all in the sea cucumber intestine in sea cucumber internal organ and sea cucumber, sea cucumber intestine and sea cucumber are for subsequent use in the lump, then by sea cucumber, the broken rear ball milling making beating of sea cucumber intestine and sea cucumber pollen, add in enzymatic vessel, add again the water of 5 ~ 10 times of sea cucumber raw material, add again liquid and the appropriate food flavor enzyme of the enzyme that contains sea cucumber self-dissolving of reservation, mix, open steam cock, gradually be warming up to 45 ~ 65 DEG C, under the condition constantly stirring, maintain constant temperature 3.5 ~ 4 hours, treating that whole liquid is clarified is substantially warming up to 100 DEG C, after 5 ~ 10 minutes, cooling is filtered, it is 2% ~ 10% that gained supernatant liquid is adjusted to concentration, then spray with the dry tower of clean spray dry, the spray powder of gained after the assay was approved, polybag vacuumizes packaging, low temperature is preserved, for subsequent use, by the salt algae element of buying on market, send inspection center inspection, the indexs such as inspection carrotene >=8%, all qualified, again by after dry salt algae element processing, putting into clean stainless steel pulverizing machine pulverizes, then cross 100 eye mesh screens, by for subsequent use after gained powder-tight packaging, get yeast dextran, send inspection center inspection, yeast dextran amount >=70%, protein≤3.5%, fat≤10%, moisture≤8%, ash content≤3%, index is all qualified, yeast dextran being put into clean stainless steel pulverizing machine pulverizes again, then cross 100 eye mesh screens, by for subsequent use after gained powder-tight packaging, get selenide of carragheen, send inspection center inspection, k-selenocarrageenan content >=2.0%, moisture≤6% qualified, selenide of carragheen being put into clean stainless steel pulverizing machine pulverizes again, then cross 100 eye mesh screens, by for subsequent use after gained powder-tight packaging, by the sea cucumber powder being up to the standards, salt algae element, yeast dextran and selenide of carragheen are 40 ~ 45 parts of sea cucumbers according to weight ratio, 20 ~ 40 parts of salt algae elements, 15 ~ 40 parts of yeast dextrans, 0.01 ~ 0.05 part of selenide of carragheen, being placed in three-dimensional mixer start mixes 20 minutes, mix, according to granulating process, with 65 ~ 70% alcohol granulations, at 80 ~ 90 degree temperature, be dried, then carry out whole grain according to particle situation, after whole grain, fill encapsulated according to production technology, in the qualified workshop of GMP, with after automatic capsule agent loading amount commissioning device according to the rules, encapsulated according to technique start, in loading amount process, check at any time product, product qualified loading amount is polished in sanding machine, after large packaging, it is to be tested qualified to move between temporary, send make-up room to pack, product again after the assay was approved, require to pack according to technological order again, inner packing completes in clean area, external packing completes in normal areas.
Below experiment shows a kind of sea cucumber salt algae glucan selenium preparation of this invention, and enhancing immunity, enhancing human body constitution are had to obvious effect.
1, strengthen body immunity
Choose 60 mouse that mouse is of the same age and various biochemical indicators are normal and identical, male and female half and half, be equally divided into four groups, every group 15, one group is control group, three groups is experimental group, the daily feed of the normal feeding of control group, experimental group is fed respectively these invention health goods of various dose, one group of low amount group of 100mg/kg, two groups of groups are amount group in 200mg/kg, three groups is 600mg/kg a large amount group, other feeding conditions and environment facies are same, after one month, choose at random 10 mouse for every group, take respectively mouse immune device spleen, thymus gland, liver, weigh, control group 4.865mg/g, one group low amount group 6.945mg/g, amount group 8.421mg/g in two groups, three groups of a large amount group 7.853mg/g, as can be seen here, control group and one group, two groups, three groups of difference are very large, one group, two groups, between three groups, difference is little,
2, strengthen human body constitution
Choose 60 mouse that mouse is of the same age and various biochemical indicators are normal and identical, male and female half and half, be equally divided into four groups, every group 15, one group is control group, three groups is experimental group, the daily feed of the normal feeding of control group, experimental group is fed respectively these invention health goods of various dose, one group of low amount group of 100mg/kg, two groups of groups are amount group in 200mg/kg, three groups is 600mg/kg a large amount group, other feeding conditions and environment facies are same, after one month, choose at random 10 mouse for every group, measure respectively mouse swimming time, control group mice 1 minute is unable sinking, one group, two groups, the swimming time of three groups all exceedes 10 minutes, as can be seen here, control group and one group, two groups, three groups of difference are very large, one group, two groups, between three groups, difference is little,
3, improve memory
Rat is divided and is four groups, 10 every group at random. one group is control group, three groups is experimental group, experimental group gives this invention health goods, blank group is normal raises, one group of low amount group of 100mg/kg, two groups of groups are amount group in 200mg/kg, three groups is 600mg/kg a large amount group, other feeding conditions and environment facies are same, feed one month continuously, then rat is placed in to lost case support arm, adapt to 5min, a wherein support arm of another two support arms presents light (no power, as place of safety), after 5S, give rat 7OV galvanism, until rat escapes place of safety, light retains 10S again, then 1 test of having turned off the light. the support arm that rat arrives place of safety is the starting position of test next time, twice training spacing 30s, amount to 1O time, misregistration reaction times, as school grade, after 24h, repeat above experiment, as the Memory result of rat, show by realizing result, the rat errors number of control group is obviously high than control rats errors number, and experimental group rat errors number is mutually not obvious, as can be seen here, control group and one group, two groups, three groups difference are very large, and between one group, two groups, three groups, difference is little,
In sum, the present invention is significantly improved to body immunity, has the function that strengthens immunity, enhancing human body constitution, improves memory.
Embodiment 1
40 parts of sea cucumbers, 20 parts of salt algae elements, 15 parts of yeast dextrans, 0.01 part of selenide of carragheen.
Embodiment 2
45 parts of sea cucumbers, 40 parts of salt algae elements, 40 parts of yeast dextrans, 0.05 part of selenide of carragheen.
Embodiment 3
43 parts of sea cucumbers, 30 parts of salt algae elements, 25 parts of yeast dextrans, 0.03 part of selenide of carragheen.
Embodiment 4
42 parts of sea cucumbers, 22 parts of salt algae elements, 38 parts of yeast dextrans, 0.04 part of selenide of carragheen.
Embodiment 5
44 parts of sea cucumbers, 37 parts of salt algae elements, 17 parts of yeast dextrans, 0.02 part of selenide of carragheen.
Crowd's test-meal result
1. follow the tracks of 60 routine patients, this 60 routine patient, immunity is low, and weather slightly changes i.e. flu, caught a cold once in average 1 ~ 2 month of winter at ordinary times, before sleeping every day, take health goods of the present invention, take after 1 month, immunity improves, the variation that can resist weather, and the number of times of catching a cold obviously reduces.
2. Song, people from Shandong, because operating pressure increases, One's spirits are drooping, feel fatigue, take health goods of the present invention every day three times, each 30 milliliters, after one week, obviously feel that fatigue alleviates, take continuously after three months, energetic, non fatigue feeling.
3. Chen, people from Shandong, female, anxious state of mind, insomnia, failure of memory, paramenia, sexual hypoesthesia, mastatrophy, skin become that coarse dark and gloomy, elasticity attenuation, pore are thick, wrinkle is deepened, aging serious, through taking goods of the present invention after one month, sleep quality is good, sleep is dark, memory increases, eumenorrhea skin is ruddy, glossy, and skin is flexible, wrinkle reduces, and is quick on the draw.
5. Cai, man, 45 years old, be engaged in network work for many years, hypoimmunity, insomnia, dreaminess, failure of memory, through taking preparation of the present invention after two months, energetic, immunity improves, and sensation health obviously has strength, is clearly better in memory simultaneously.
As can be seen here, through taking sea cucumber salt algae glucan selenium preparation of the present invention, there is obvious effect to strengthening immunity, enhancing human body constitution, raising memory etc.
Claims (4)
1. a sea cucumber salt algae glucan selenium preparation, it is characterized in that said preparation is made up of sea cucumber, salt algae element, yeast dextran and selenide of carragheen, wherein each components by weight of sea cucumber, salt algae element, yeast dextran and selenide of carragheen is: 40 ~ 45 parts of sea cucumbers, 20 ~ 40 parts of salt algae elements, 15 ~ 40 parts of yeast dextrans, 0.01 ~ 0.05 part of selenide of carragheen.
2. a preparation technology for sea cucumber salt algae glucan selenium preparation, is characterized in that making step is as follows:
(1): first fresh sea cucumber is cleaned, cut off, remove internal organ, retain the liquid of the enzyme that contains sea cucumber self-dissolving flowing out, and by the impurity Ex-all in the sea cucumber intestine in sea cucumber internal organ and sea cucumber, sea cucumber intestine and sea cucumber are for subsequent use in the lump, then by sea cucumber, the broken rear ball milling making beating of sea cucumber intestine and sea cucumber pollen, add in enzymatic vessel, add again the water of 5 ~ 10 times of sea cucumber raw material, add again liquid and the appropriate food flavor enzyme of the enzyme that contains sea cucumber self-dissolving of reservation, mix, open steam cock, gradually be warming up to 45 ~ 65 DEG C, under the condition constantly stirring, maintain constant temperature 3.5 ~ 4 hours, treating that whole liquid is clarified is substantially warming up to 100 DEG C, after 5 ~ 10 minutes, cooling is filtered, it is 2% ~ 10% that gained supernatant liquid is adjusted to concentration, then spray with the dry tower of clean spray dry, the spray powder of gained after the assay was approved, polybag vacuumizes packaging, low temperature is preserved, for subsequent use,
(2): by the salt algae element of buying on market, send inspection center inspection, inspection carrotene >=8%, A, B,,, index, all qualified, again by after dry salt algae element processing, put into clean stainless steel pulverizing machine and pulverize, then cross 100 eye mesh screens, by for subsequent use after gained powder-tight packaging;
(3): get yeast dextran, send inspection center inspection, yeast dextran amount >=70%, protein≤3.5%, fat≤10%, moisture≤8%, ash content≤3%, index are all qualified, yeast dextran being put into clean stainless steel pulverizing machine pulverizes again, then cross 100 eye mesh screens, by for subsequent use after gained powder-tight packaging;
(4): get selenide of carragheen, send inspection center inspection, k-selenocarrageenan content >=2.0%, moisture≤6% qualified, then selenide of carragheen is put into clean stainless steel pulverizing machine and pulverize, then cross 100 eye mesh screens, by for subsequent use after gained powder-tight packaging;
(5): be 40 ~ 45 parts of sea cucumbers by the sea cucumber powder being up to the standards, salt algae element, yeast dextran and selenide of carragheen according to weight ratio, 20 ~ 40 parts of salt algae elements, 15 ~ 40 parts of yeast dextrans, 0.01 ~ 0.05 part of selenide of carragheen, be placed in three-dimensional mixer start and mix 20 minutes, mix;
(6): according to granulating process, with 65 ~ 70% alcohol granulations, at 80 ~ 90 degree temperature, be dried, then carry out whole grain according to particle situation.
3. the preparation technology of a kind of sea cucumber salt algae glucan selenium preparation according to claim 2, it is characterized in that filling encapsulated according to production technology after described whole grain, in the qualified workshop of GMP, with after automatic capsule agent loading amount commissioning device according to the rules, encapsulated according to technique start, in loading amount process, check at any time product, product qualified loading amount is polished in sanding machine, after large packaging, it is to be tested qualified to move between temporary, send make-up room to pack, product again after the assay was approved, require to pack according to technological order again, inner packing completes in clean area, external packing completes in normal areas.
4. the preparation technology of a kind of sea cucumber salt algae glucan selenium preparation according to claim 2, is characterized in that after described whole grain according to the agent of technological process of production granulation, capsule preparations or chewable tablets.
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