CN102475759B - Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection - Google Patents
Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection Download PDFInfo
- Publication number
- CN102475759B CN102475759B CN 201110325974 CN201110325974A CN102475759B CN 102475759 B CN102475759 B CN 102475759B CN 201110325974 CN201110325974 CN 201110325974 CN 201110325974 A CN201110325974 A CN 201110325974A CN 102475759 B CN102475759 B CN 102475759B
- Authority
- CN
- China
- Prior art keywords
- time
- water
- add
- amounts
- filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Shenkang sodium chloride injection for treating chronic renal failure, which is prepared from the following raw materials in the mass ratio: 1500g of rheum officinale, 1500g of roots of red-rooted salvia, 4500g of Astragalus mongholicus, 1500g of red flower and 810g of sodium chloride. The preparation method comprises the following steps of: after the bulk pharmaceutical chemicals of the rheum officinale and the roots of the red-rooted salvia are extracted in the ratio in the formula, carrying out primary ethanol precipitation, removing tan, carrying out secondary ethanol precipitation and water precipitation, carrying out third ethanol precipitation, and carrying out secondary water precipitation to remove pyrogen and sterilize; then, extracting the red flower and the Astragalus mongholicus in the ratio in the formula, carrying out primary ethanol precipitation and water precipitation, and carrying out secondary ethanol precipitation and water precipitationto remove pyrogen and sterilize by activated carbon; and finally, combining the two groups of liquid medicine, carrying out ultrafiltration, adding sodium chloride, carrying out fine filtering and sterilizing to obtain the Shenkang sodium chloride injection. The Shenkang sodium chloride injection for treating chronic renal failure has the advantages that the Shenkang sodium chloride injection canbe directly used to prevent medicine from being diluted again so as to lower secondary pollution brought by the process; the Shenkang sodium chloride injection is convenient for doctors and nurses touse, the compliance of a patient using the medicine is improved; and the Shenkang sodium chloride injection can be used for patients suffering from diabetes mellitus.
Description
Technical field
The invention belongs to the Chinese medicine preparation injection, particularly about a kind of kidney health sodium chloride injection for the treatment of chronic renal failure and preparation method thereof.
Background technology
Former patent 96117626.1 discloses a kind of SHENKANG ZHUSHEYE and preparation method thereof; what its prescription was protected is the Chinese medicine scope of application; there is not concrete proportion relation; although in patent document embodiment, also disclose the case of prescription; but Radix Astragali use amount is high, because the Radix Astragali and Radix Et Rhizoma Rhei have precipitation, the Radix Astragali and Radix Salviae Miltiorrhizae also can react; if Radix Astragali input amount in the compatibility of preparation is few, can affect drug effect again.Accurate and little side effect for the intravenous fluid active constituent content is vital.In addition, the present invention can directly use, and has avoided the again dilution of medicine, reduces the secondary pollution that may bring in this process, makes things convenient for doctors and nurses's use, improves the compliance of patient's medication, can be used for diabetic nephropathy patient.
Summary of the invention
One of purpose of the present invention is: a kind of kidney health sodium chloride injection for the treatment of chronic kidney hypofunction is provided, and it is to have done accurate adjustment in original proportioning, and effective percentage is high, easy to use, avoided pollution possible in the use procedure, side effect is little, effect is rapid, and bioavailability is high.
Two of purpose of the present invention is: a kind of preparation method for the treatment of the kidney health sodium chloride injection of chronic kidney hypofunction is provided, and it can further improve product quality and production efficiency.
Technical scheme of the present invention is: a kind of kidney health sodium chloride injection for the treatment of chronic kidney hypofunction is provided, and it is characterized in that: it is made by the raw material of following proportioning: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g, sodium chloride 810g.
The preparation method of kidney health sodium chloride injection of the present invention is: after crude drug Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae are extracted by above-mentioned formula proportion amount, first precipitate with ethanol, tannin-removing, again secondary precipitate with ethanol, water precipitating, repeatedly behind time precipitate with ethanol, the secondary water precipitating, depyrogenation, sterilization; Again with the Radix Astragali, Flos Carthami by above-mentioned formula proportion amount extract, again precipitate with ethanol, water precipitating, again behind secondary precipitate with ethanol, the water precipitating, active carbon depyrogenation, sterilization; Merge at last above two groups of diluents, through ultrafiltration, adding sodium chloride, fine straining, sterilization forms.
The preparation method of kidney health sodium chloride injection of the present invention: get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, for the first time amount of water is that the 7-12 of crude drug doubly measures, after soaking 30min, boil 30min, filter, for the second time amount of water is that the 7-12 of crude drug doubly measures, boil 30min, filter, amount of water is that the 7-12 of crude drug doubly measures for the third time, boils 30min, filters, merge three times water extraction liquid, when being concentrated into 60 ℃ of relative densities 1.18～1.25, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leave standstill 38-60h, get supernatant liquid filtering to clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.18～1.25, add 5% gelatin solution, tannin-removing, adding 95% ethanol, is 75% to containing the alcohol amount, leaves standstill 38-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.18～1.25, add water for injection to 4 times of amounts of medicinal liquid, it is clear and bright and when being concentrated into relative density and being 60 ℃ 1.18～1.25 that cold preservation 38～55h gets supernatant liquid filtering, adding 95% ethanol is 80% to containing the alcohol amount, leave standstill 38-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.18～1.25, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 38～55h; Get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation, adjust pH is put sterilization in the sealing bucket to 6.5-7.8, and is for subsequent use; The dosage Flos Carthami, Milkvetch Root, for the first time amount of water is that the 7-12 of crude drug doubly measures, soak 30min, boil 45min, filter, for the second time amount of water is that the 7-12 of crude drug doubly measures, boil 45min, filter, amount of water is that the 7-12 of crude drug doubly measures for the third time, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.18～1.25, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leaves standstill 38-60h, gets supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.18～1.25, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 38～55h gets supernatant liquid filtering clear and bright and be concentrated into relative density in the time of 60 ℃ 1.18～1.25, add 95% ethanol, containing alcohol amount to medicinal liquid is 80%, and leaving standstill 38-60h, to get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.18～1.25, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation, adjust pH is to 6.5-7.8, put sterilization in the sealing bucket, for subsequent use; The intermediate of above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group is sequentially added into, adds again water for injection and be diluted to full dose, stir, ultrafiltration, after 15 minutes adjust pH to 6.5～7.8 through the filter circulation for the sodium chloride of adding dosage, filter sterilization.
Kidney health chloride injection liquid and preparation method thereof of the present invention is: get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, amount of water is 10 times of amounts of crude drug for the first time, after soaking 30min, boil 30min, filter, amount of water is 8 times of amounts of crude drug for the second time, boil 30min, filter, amount of water is 7 times of amounts of crude drug for the third time, boils 30min, filters, merge three times water extraction liquid, when being concentrated into 60 ℃ of relative densities 1.20～1.22, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leave standstill 48-60h, get supernatant liquid filtering to clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add 5% gelatin solution, tannin-removing, adding 95% ethanol, is 75% to containing the alcohol amount, leaves standstill 48-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 42～55h gets that supernatant liquid filtering is clear and bright and to be concentrated into relative density be 60 ℃ 1.20～1.22, adding 95% ethanol is 80% to containing the alcohol amount, leave standstill 48-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 42～55h; Get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation, adjust pH is put 105 ℃ of sterilization 1h in the sealing bucket to 7.5-7.8, and is for subsequent use; The dosage Flos Carthami, Milkvetch Root, amount of water is 10 times of amounts of crude drug for the first time, soak 30min, boil 45min, filter, amount of water is 8 times of amounts of crude drug for the second time, boil 45min, filter, amount of water is 7 times of amounts of crude drug for the third time, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leaves standstill 48-60h, gets supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 42～55h gets supernatant liquid filtering clear and bright and be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, containing alcohol amount to medicinal liquid is 80%, and leaving standstill 48-60h, to get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 42～55h, get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation, adjust pH is to 7.5-7.8, put 105 ℃ of sterilization 1h in the sealing bucket, for subsequent use; The intermediate of above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group is sequentially added into, adds again water for injection and be diluted to full dose, stir, ultrafiltration, after 15 minutes adjust pH to 7.5～7.6 through the filter circulation for the sodium chloride of adding dosage, filter sterilization.
The invention has the advantages that:
One, its prescription proportioning is the improvement of doing on original patent 96117626.1,03141399.4, ZL03108156.8, ZL200410039420.7, ZL200410004359.2, ZL200410039418 basis, because Radix Astragali input amount is high in the former patent, because the Radix Astragali and Radix Et Rhizoma Rhei have precipitation, the Radix Astragali and Radix Salviae Miltiorrhizae also can react, if Radix Astragali input amount in the compatibility of preparation is few, can affect drug effect again.The invention has the advantages that medicine directly by intravenous injection, effect is rapid, and bioavailability is high, short treating period, and good effect has QI invigorating and consolidates, and the effect of dissipating stasis and purging turbidity is applicable to chronic renal failure, especially infringement more than the renal function moderate is had better effects.Investigate five kinds of prescriptions to the impact of Chronic Renal Failure Rats by zoopery.The proportioning of ZL200410039420.7, ZL200410039418.X embodiment is 1.0: 1.0: 7.0: 1.0 and 1.5: 1.5: 5.5: 1.5, ZL03108156.8,03141399.4 prescription proportioning in an embodiment is 1.5: 1.0: 1.0: 1.5, several patent taste of Chinese medicine proportion relations are fully different.The present invention proves that through a large amount of experiment contrasts proportioning effect of the present invention is better, and its experiment Data Comparison is as follows:
Prescription one consumption is: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g.
Prescription two consumptions are: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 5500g, Flos Carthami 1500g.
Prescription three consumptions are: Radix Et Rhizoma Rhei 1667g, Radix Salviae Miltiorrhizae 1667g, Radix Astragali 5000g, Flos Carthami 1666g.
Prescription four-function amount is: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1000g, Radix Astragali 1500g, Flos Carthami 1000g.
Prescription five consumptions are: Radix Et Rhizoma Rhei 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Astragali 7000g, Flos Carthami 1000g.
Animal experiment study shows: five kinds of prescriptions all can reduce chronic renal failure (CRF) rat serum blood urea nitrogen (BUN), creatinine (Cr) level, alleviate the azotemia that carrying out property increases the weight of, rising hemoglobin (Hb), improve anemia, still can improve albumin (ALB) level to adenine CRF rat, renal hypertrophy is alleviated, and the kidney coefficient obviously reduces.And prescription one effect is more obvious, is better than it and respectively organizes prescription.Experimental result sees following table 1-5 for details.
Five kinds of prescriptions of table 1 are on the impact of CRF rat blood serum blood urea nitrogen due to the adenine relatively (mmol/L, X ± SD)
Compare * P＜0.05, * * P＜0.01 with model group
Five kinds of prescriptions of table 2 are on the impact of CRF rat blood serum creatinine due to the fast mountain range of gland relatively (μ mol/L, X ± SD)
Compare with model group: * P＜0.05, * * P＜0.01
Experimental result shows: the rats gavaged adenine is after two weeks, and blood BUN, Cr raise, and is significantly higher than normal rat (p＜0.01), shows that CRF forms, and grouping is treated.Continue to the rats gavaged adenine during the treatment, its blood BUN, Cr continues to rise, after treating for 5 weeks, model group rat BUN, Cr rise to respectively 6.5 times of normal rat with 4.3 times, show the azotemia that carrying out property of this Model Representation increases the weight of, the injection tail vein injection treatment rat made from five kinds of prescriptions respectively, its blood BUN, Cr is along with the blood BUN of model group rat, the rising of Cr also raises gradually, the blood BUN for the treatment of group rat, the Cr rate of climb and amplitude will be lower than model group, after 3 weeks for the treatment of and 5 weeks, the blood BUN for the treatment of group, the Cr level is starkly lower than model group (p＜0.05 or p＜0.01), and the blood BUN of prescription one treatment group rat, the Cr rate of climb and amplitude still are lower than all the other each prescription groups, show that prescription one reduces the blood BUN of adenine CRF rat, Cr, improve the effect of azotemia, be better than prescription two and prescription three, prescription four, prescription five.
Five kinds of prescriptions of table 3 are on the impact of CRF rat hemoglobin due to the adenine relatively (g/L, X ± SD)
Compare with model group: * P＜0.05, * * P＜0.01
Experimental result shows: the rats gavaged adenine is after two weeks, and the Hb level is existing to descend, and along with the increase that gives the adenine number of days, Hb also decreases, and after 5 weeks for the treatment of, model group rat Hb level significantly is lower than normal rat (P＜0.01).Although injection for treating group rat Hb is also reducing gradually, decrease speed is slower, and during 5 week, its Hb level is significantly higher than the model group same period (P＜0.05) in treatment, and the successful of prescription one is better than all the other each prescription groups.Show that prescription one can alleviate the Anemia of adenine CRF rat, effect is better than prescription two and prescription three, prescription four, prescription five.
Five kinds of prescriptions of table 4 are on the impact of CRF rat serum albumin due to the adenine relatively (g/L, X ± SD)
Compare with model group: * P＜0.05, * * P＜0.01
Experimental result shows: the model group rat is after 5 weeks for the treatment of, serum albumin obviously reduces (comparing P＜0.05 with normal rat), hypoalbuminemia when treatment group can be improved rat CRF, serum albumin levels is significantly higher than model group (p＜0.05) when treating for 5 week.Prescription one effect is significantly better than all the other four groups.
Five kinds of prescriptions of table 5 are on the impact of CRF kidney of rats coefficient due to the adenine relatively (mg/100g body weight, X ± SD)
Compare with model group: * P＜0.05, * * P＜0.01
Experimental result shows: the rat of oral adenine retains right renal hypertrophy, and weight obviously increases, normal 4.4 times of the kidney coefficient average out to of model group.The kidney coefficient of injection for treating group rat all is less than model group, and there were significant differences for the kidney coefficient (p＜0.01 and p＜0.05), and prescription one kidney coefficient is less than all the other four groups.
Two, the present invention can directly use, and has avoided the again dilution of medicine, has reduced medicine and has diluted the secondary pollution that may bring again, and makes things convenient for doctors and nurses's use, improves the compliance of patient's medication, can be used for diabetic nephropathy patient.
Animal experiment study shows: kidney health sodium chloride injection can obviously reduce chronic renal failure (CRF) rat serum blood urea nitrogen (BUN), creatinine (Cr) level, alleviate the azotemia that carrying out property increases the weight of, rising hemoglobin (Hb), improve anemia, still can improve albumin (ALB) level to 5/6 nephrectomy CRF rat, renal hypertrophy is alleviated, and the kidney coefficient reduces, and experimental result sees following table 1-5 for details.
Table 1 kidney health sodium chloride injection is on the impact of 5/6 nephrectomy CRF rat blood serum blood urea nitrogen (mmol/L, X ± SD)
Annotate: compare with model group: * P＜0.05, * * P＜0.01
Table 2 kidney health sodium chloride injection is on the impact of 5/6 nephrectomy CRF rat blood serum creatinine (μ mol/L, X ± SD)
Annotate: compare with model group: * P＜0.05, * * P＜0.01
Experimental result shows: after rat was cut 5/6 nephridial tissue, carrying out property of blood BUN, Cr increased, postoperative 5 all BUN, Cr rise to respectively 6.2 times of normal rat with 4.1 times, show that CRF forms.During kidney health sodium chloride injection treatment, relatively have no obvious rising before the BUN of each treatment group rat, Cr level and self treatment, treat also slightly decline after 5 weeks, with the same period model group compare, the BUN for the treatment of group, Cr level are all lower.
Table 3 kidney health sodium chloride injection is on the impact of 5/6 nephrectomy CRF rat hemoglobin (g/L, X ± SD)
Annotate: compare with model group: * P＜0.05, * * P＜0.01
Table 4 kidney health sodium chloride injection is on the impact of 5/6 nephrectomy CRF rat serum albumin (g/L, X ± SD)
Annotate: compare with model group: * P＜0.05, * * P＜0.01
Shown by table 3,4 results: 8 weeks after the nephrectomy, obvious anemia and hypoproteinemia have appearred in rat, and put off in time and continue to increase the weight of, kidney health sodium chloride injection is improved the effect of its anemia, than model group rebound significantly (p＜0.05) is arranged to treating for 5 whens week.To hypoalbuminemia, kidney health sodium chloride injection also has some improvement.
Table 5 kidney health sodium chloride injection is on the impact of 5/6 nephrectomy CRF kidney of rats coefficient (mg/100g body weight, X ± SD)
Annotate: compare with model group: * P＜0.05, * * P＜0.01
Experimental result shows: the execution rat is cutd open and gets kidney after 5 weeks for the treatment of, and visible residual kidney obviously increases (the average kidney coefficient of model group is 1.6 times of normal group) when performing the operation.The kidney coefficient of kidney health sodium chloride injection treatment group rat is less than model group.Show that treatment group can alleviate the glomerule hypertrophy, suppress mesangial cell and matrix secreted, obviously reduce the hardening ratio of glomerule, alleviate renal tubules overdistension and epithelial damage, alleviate interstitial fibrosis, promote reparation and the mitochondrial hyperplasia of renal cells.
Three, the contrast of the preparation method of described kidney health sodium chloride injection and 96117626.1 preparation methoies is as follows:
1, in patent 96117626.1 preparation methoies, the medicinal material extract water consumption is 7 times of medical material amount, and existing process water consumption is 7-12 times; 7 times of water consumptions of former technique, after medical material soaks 30min, most of water that extracts is absorbed by medical material, and extraction efficiency reduces, and causes part medical material active substance not to be fully extracted, and after being increased to 10 times, most of working substance mass-energy extracts fully, but surpasses 14 times, and the impurity extracted amount also increases, the effective ingredient content back has the decline phenomenon, and has greatly increased energy consumption.Amount of water is 10 times for the first time, and 8 times for the second time, 7 times of effects are best for the third time.
2, the present invention adds 95% ethanol, and containing the alcohol amount to medicinal liquid is 70%, leaves standstill 48-60h, and this time precipitate with ethanol effect is better than the 12h of patent 96117626.1, and active constituent content is high after testing, precipitate fully and completely, but the overlong time production cost is higher.
3, in patent 96117626.1 preparation methoies Recycled ethanol to without alcohol flavor, not concrete control index, the bad control of production process, the present invention during at this moment with 60 ℃ of relative densities 1.20～1.25 as detecting, so that the production control procedure quality.
4, under agitation in condensed cream, slowly add 4% gelatin solution in patent 96117626.1 preparation methoies, and the present invention adds 5% gelatin solution tannin-removing; Add 95% ethanol, patent 96117626.1 is to add 250ml to calculate and contain the alcohol amount and be approximately 60%, is difficult to remove tannin, and the present invention adds to that to contain alcohol amount 75% its tannin-removing effect better, and the quality of production is easily controlled.
Such as the gelatin with variable concentrations the tannin-removing effect that Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae extract rear medicinal liquid is compared, best with gelatin 5%, 4% gelatin is because concentration is rarer, the gelatin solution use amount is excessive in the tannin-removing process, increased the volume of medicinal liquid, reduced the concentration of medicinal liquid, not only the tannin-removing effect is relatively poor, has also strengthened man-hour simultaneously, has improved energy consumption, 6% gelatin solution, because gelatin solution concentration is excessive, effective ingredient easily is wrapped and loses, and causes active constituent content to reduce, therefore through test of many times, 5% gelatin solution tannin-removing effect is better and medicinal liquid extraction component content is higher; Alcohol precipitation concentration confirms through overtesting behind the tannin-removing, when alcohol precipitation concentration is 60%, gelatin in the medicinal liquid is difficult to eliminate, and 75% alcohol precipitation concentration namely can be removed the unnecessary gelatin behind the tannin-removing fully, form gradient with one, two, three precipitate with ethanol again, be conducive to the extraction of effective ingredient and the removal of invalid components, and the high consumption of ethanol content is relatively few, not only capable of reducing energy consumption but also can reduce work hours.
5, secondary precipitate with ethanol extracting solution uses distilled water diluting 14 to 84ml in patent 96117626.1 preparation methoies, and the feasibility of operation is not strong, and scope is crossed the control of large-scale production process difficult quality.So the present invention adopts 4 times of amounts to add water for injection so that control quality and operation in the production process.
6, increased in the technique of the present invention medicinal liquid evenly is sub-packed in the special stainless steel storage vat, airtight, at 105 ℃ of flowing steam sterilization 60min, medicinal liquid is by the intermediate quality standard subsequent processing of being allowed for access after the assay was approved after the sterilization.The present invention has increased the sterilization process of intermediate in technique, reduced the bacteria containing amount of pharmaceutical intermediate, guarantees the aseptic requirement of product.
7, active carbon is decolouring and removes pyrogen in the medicinal liquid in the purpose of this application, and addition directly has influence on content's index and the depyrogenation effect of medicinal liquid.Addition is excessive, and loss of effective components is large, causes finished product content defective; Addition is few, is difficult to guarantee that decolouring and medicinal liquid pyrogen are qualified.The active carbon addition is generally 0.1-2.0% in the known technology, and scope is larger, operating difficulties; Addition of the present invention is 0.5%, compares with 0.63% of patent 96117626.1, has both kept more effective ingredient, and pyrogen test again can be qualified.
8, adopt grouping to take off charcoal in the production technology of the present invention, it with merging filtrate after take off charcoal and compare: merge that to take off charcoal larger to chrysophanol in the extracting solution, emodin, general anthraquinone composition influence, effective ingredient obviously reduces, if active constituent content is excessively low, two groups of materials all will cancel, and increase production cost and risk; Grouping is taken off charcoal and can effectively be controlled its content, has reduced production cost and risk.
9, adopt ultrafiltration to filter in the preparation method of the present invention, can guarantee decolorizing effect, can remove again macromolecular substances and anaphylactogen in the medicine, improve the quality of products, guarantee safe medication.
10, medicinal liquid of the present invention is successively after 2 filters that 0.22 μ m microporous filter membrane is housed filter, can effectively guarantee the aseptic level of medicinal liquid during embedding, and patent 96117626.1 medicinal liquids filter through 1 filter that 0.45 μ m microporous filter membrane is housed after embedding, confirm not reach preferably filtration sterilization effect through the challenge test.
11, the sterilising conditions temperature is relatively:
Experiment shows, 100 ℃ of sterilising conditions, and 1h, 110 ℃, 1h, 115 ℃, 35min, 121 ℃, 8min all can guarantee the aseptic level of medicine, and product detection no significant difference, therefore sterilising temp can be decided to be 100-110 ℃, time 1h, 115 ℃ of temperature, 35～45min; 121 ℃ of temperature, 8～30min all can guarantee the aseptic requirement of product.
Four, the preparation method of described kidney health sodium chloride injection and patent 03141399.4 contrast are as follows
1. the prescription proportioning is different, and prescription of the present invention is Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g.The prescription of patent 03141399.4 is a scope, and the present invention is not in its scope, and the proportioning in the embodiment is Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1000g, Radix Astragali 1500g, Flos Carthami 1000g.
2. in patent 03141399.4 preparation method, 100mL * 50mL, not offering some clarification on is what, does not know that also what the content of explaining is, do not possess operability.And the present invention clear and definite the water yield of extracting, decoct with water three times, have operability.
3. in patent 03141399.4 preparation method, do not have the process of water soaking, medicinal liquid extracts not exclusively; The clear and definite soak time 30min of the present invention, extraction time 30min is more complete to the extraction of effective ingredient.Contrast as follows.
4. in patent 03141399.4 preparation method, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae extract are concentrated into 1: 1.5 (mL: g); Flos Carthami, Radix Astragali extractive solution are concentrated into 1: 2.2, and (mL: g), operability is not strong, and process is difficult to control; When the present invention is concentrated into 60 ℃ of relative densities 1.20～1.23, workable, can control concentration process.
5. in patent 03141399.4 preparation method, Recycled ethanol does not have concrete detect index, the bad control of production process to without the alcohol flavor; 1.20～1.22 as detecting indexs when the present invention was concentrated into 60 ℃ of relative densities, can effectively control the product quality in the drug production process.
Five, the preparation method of described kidney health sodium chloride injection and ZL 03108156.8 contrast are as follows
1. the prescription proportioning is different, and prescription of the present invention is Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g.
The prescription of ZL 03108156.8 is Radix Et Rhizoma Rhei: Radix Salviae Miltiorrhizae: Flos Carthami: the Radix Astragali 1.5: 1: 1: 1.5, and this ratio does not comprise prescription of the present invention.
2.ZL 03108156.8 preparation method Chinese medicine is prescription in proportion, not concrete prescription, and the not concrete mode of operation of extracting does not possess operability yet.
3.ZL in 03108156.8 preparation method, do not have the process of water soaking, medicinal liquid extracts not exclusively, the clear and definite soak time 30min of the present invention, extraction time 30min is more complete to the extraction of effective ingredient.Contrast as follows
4.ZL in 03108156.8 preparation method, the precipitate with ethanol time, the precipitate with ethanol temperature is all not clear and definite, does not possess operability.
5.ZL in 03108156.8 preparation method, filtrate is concentrated into 5 gram dry/mL filtrates, behind 80% precipitate with ethanol, adds again entry and is diluted to 5 gram dry/mL solution, can't operate.
Six, the preparation method of described kidney health sodium chloride injection and ZL200410039420.7 contrast is as follows
1. the prescription proportioning is different, and prescription of the present invention is Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g; Ratio among the ZL200410039420.7, not concrete prescription, and the proportioning among the embodiment is Radix Et Rhizoma Rhei: Radix Salviae Miltiorrhizae: the Radix Astragali: Flos Carthami is 15: 15: 55: 15, and different with formula proportion of the present invention.
2.ZL200410039420.7 decocting time is 1-2h in the preparation method, overlong time, and energy consumption is excessive, and the impurity level of extraction also increases relatively; Decocting time of the present invention is 30min, and energy consumption is suitable, and in effective component extracting preferably, the impurity level of extraction is also relatively less.
3.ZL200410039420.7 behind the precipitate with ethanol, Recycled ethanol is to distinguishing the flavor of without alcohol in the preparation method, fuzzyyer, the present invention is concentrated into the regulation relative density, and is workable.
4.ZL200410039420.7 merge two groups of filtrates in the preparation method, after activated carbon adsorption is filtered, inject and be diluted with water to 50% concentration; The present invention divides into groups to add active carbon can better remove pigment and pyrogen, improves the quality of products and safety.
Seven, the preparation method of described kidney health sodium chloride injection and ZL200410004359.2 contrast is as follows:
1, there is not the medical material immersion process in the ZL200410004359.2 preparation method, and decocting time 1-2h, the time is longer, and extraction efficiency is lower; And the present invention soaks 30min, decocts 30min more reasonable.
2, be concentrated into relative density 1.00-1.15 behind the collecting decoction in the ZL200410004359.2 preparation method, alcohol adding amount is larger, and expends man-hour; The present invention is concentrated into relative density 1.20-1.23, can enhance productivity preferably.
3, filter 1 time through 0.2 μ m microporous filter membrane in the ZL200410004359.2 preparation method; The present invention can better remove impurities and bacteria through 0.22 μ m filtering with microporous membrane 2 times.
Eight, the preparation method of described kidney health sodium chloride injection and ZL200410039418.X contrast is as follows:
1. the prescription proportioning is different, and prescription of the present invention is Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g.Be ratio among the ZL200410039418.X, not concrete prescription, and the proportioning among the embodiment is Radix Et Rhizoma Rhei: Radix Salviae Miltiorrhizae: the Radix Astragali: Flos Carthami is 10: 10: 70: 10 and 15: 15: 55: 15,20: 20: 40: 40, and different with formula proportion of the present invention.
2.ZL200410039418.X 1.20-1.23 when being concentrated into 80 ℃-90 ℃ of relative densities in the preparation method, operability is relatively poor; When the present invention is concentrated into relative density and is 60 ℃ 1.20～1.23, more easy to operate and control quality.
3.ZL200410039418.X do not have tannin-removing technique in the preparation method, Impurity removal is incomplete.
4.ZL200410039418.X Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae and the Radix Astragali, Flos Carthami all only carry out one time precipitate with ethanol in the preparation method; The present invention removes impurity more thorough through precipitate with ethanol repeatedly.
The specific embodiment
Embodiment 1
Kidney health sodium chloride injection of the present invention, it is made by the raw material of following proportioning: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g, sodium chloride 810g.
After crude drug Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae extracted by above-mentioned formula proportion amount, first precipitate with ethanol, tannin-removing, again secondary precipitate with ethanol, water precipitating, repeatedly behind time precipitate with ethanol, the secondary water precipitating, depyrogenation, sterilization; Again with the Radix Astragali, Flos Carthami by above-mentioned formula proportion amount extract, again precipitate with ethanol, water precipitating, again behind secondary precipitate with ethanol, the water precipitating, active carbon depyrogenation, sterilization; Merge at last above two groups of diluents, form through ultrafiltration, adding sodium chloride, fine straining → packing → sterilization → quality inspection → packing.
Embodiment 2
Kidney health sodium chloride injection of the present invention, make by following preparation method: get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, for the first time amount of water is that the 7-12 of crude drug doubly measures, after soaking 30min, boil 30min, filter, for the second time amount of water is that the 7-12 of crude drug doubly measures, boil 30min, filter, amount of water is that the 7-12 of crude drug doubly measures for the third time, boil 30min, filter, merge three times water extraction liquid, when being concentrated into 60 ℃ of relative densities 1.18～1.25, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leaves standstill 38-60h, gets supernatant liquid filtering to clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.18～1.25, add 5% gelatin solution, tannin-removing adds 95% ethanol, be 75% to containing alcohol amount, leave standstill 38-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.18～1.25, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 38～55h gets that supernatant liquid filtering is clear and bright and to be concentrated into relative density be 60 ℃ 1.18～1.25, and adding 95% ethanol is 80% to containing the alcohol amount, leaves standstill 38-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.18～1.25, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 38～55h; Get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation, adjust pH is put sterilization in the sealing bucket to 6.5-7.8, and is for subsequent use; The dosage Flos Carthami, Milkvetch Root, for the first time amount of water is that the 7-12 of crude drug doubly measures, soak 30min, boil 45min, filter, for the second time amount of water is that the 7-12 of crude drug doubly measures, boil 45min, filter, amount of water is that the 7-12 of crude drug doubly measures for the third time, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.18～1.25, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leaves standstill 38-60h, gets supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.18～1.25, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 38～55h gets supernatant liquid filtering clear and bright and be concentrated into relative density in the time of 60 ℃ 1.18～1.25, add 95% ethanol, containing alcohol amount to medicinal liquid is 80%, and leaving standstill 38-60h, to get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.18～1.25, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation, adjust pH is to 6.5-7.8, put sterilization in the sealing bucket, for subsequent use; The intermediate of above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group is sequentially added into, add again water for injection and be diluted to full dose, stir, ultrafiltration, after 15 minutes adjust pH to 6.5～7.8 in the filter circulation of the sodium chloride of adding dosage through 0.45 μ m microporous filter membrane is housed, detection level is qualified, and medicinal liquid is embedding after 2 filters that 0.22 μ m microporous filter membrane is housed filter successively, sterilization.
Embodiment 3
Kidney health chloride injection liquid and preparation method thereof of the present invention is: after Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g medical material are selected, and cleaning, infiltration, cutting, oven dry; Take by weighing the Radix Et Rhizoma Rhei 1500g of dosage, Radix Salviae Miltiorrhizae 1500g medical material, amount of water is 10 times of amounts of crude drug for the first time, after soaking 30min, boil 30min, filter, amount of water is 8 times of amounts of crude drug for the second time, boil 30min, filter, amount of water is 7 times of amounts of crude drug for the third time, boils 30min, filters, merge three times water extraction liquid, when being concentrated into 60 ℃ of relative densities 1.20～1.22, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leave standstill 48-60h, get supernatant liquid filtering to clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add 5% gelatin solution, tannin-removing, adding 95% ethanol, is 75% to containing the alcohol amount, leaves standstill 48-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 42～55h gets that supernatant liquid filtering is clear and bright and to be concentrated into relative density be 60 ℃ 1.20～1.22, adding 95% ethanol is 80% to containing the alcohol amount, leave standstill 48-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 42～55h; Get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation transfers pH value to 7.5-7.8, puts 105 ℃ of sterilization 1h in the sealing bucket, and is for subsequent use; The dosage Flos Carthami, Milkvetch Root, amount of water is 10 times of amounts of crude drug for the first time, soak 30min, boil 45min, filter, amount of water is 8 times of amounts of crude drug for the second time, boil 45min, filter, amount of water is 7 times of amounts of crude drug for the third time, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leaves standstill 48-60h, gets supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 42～55h gets supernatant liquid filtering clear and bright and be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, containing alcohol amount to medicinal liquid is 80%, and leaving standstill 48-60h, to get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 42～55h, get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation transfers pH value to 7.5-7.8, put 105 ℃ of sterilization 1h in the sealing bucket, for subsequent use; The intermediate of above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group is sequentially added into, add again water for injection and be diluted to full dose, stir, ultrafiltration, after 15 minutes adjust pH to 7.5～7.6 in the filter circulation of the sodium chloride of adding dosage through 0.45 μ m microporous filter membrane is housed, detection level is qualified, and medicinal liquid is embedding after 2 filters that 0.22 μ m microporous filter membrane is housed filter successively, sterilization.
Claims (2)
1. kidney health sodium chloride injection for the treatment of chronic kidney hypofunction, it is characterized in that: the raw material composition and ratio is: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g, sodium chloride 810g; Make by following preparation method,
Get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, amount of water is 10 times of amounts of crude drug for the first time, after soaking 30min, boil 30min, filter, amount of water is 8 times of amounts of crude drug for the second time, boil 30min, filter, amount of water is 7 times of amounts of crude drug for the third time, boils 30min, filters, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leave standstill 48-60h, get supernatant liquid filtering to clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add 5% gelatin solution, tannin-removing, adding 95% ethanol, is 75% to containing the alcohol amount, leaves standstill 48-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 42～55h gets that supernatant liquid filtering is clear and bright and to be concentrated into relative density be 60 ℃ 1.20～1.22, adding 95% ethanol is 80% to containing the alcohol amount, leave standstill 48-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 42～55h; Get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation, adjust pH is put 105 ℃ of sterilization 1h in the sealing bucket to 7.5-7.8, and is for subsequent use; The dosage Flos Carthami, Milkvetch Root, amount of water is 10 times of amounts of crude drug for the first time, soak 30min, boil 45min, filter, amount of water is 8 times of amounts of crude drug for the second time, boil 45min, filter, amount of water is 7 times of amounts of crude drug for the third time, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leaves standstill 48-60h, gets supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 42～55h gets supernatant liquid filtering clear and bright and be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, containing alcohol amount to medicinal liquid is 80%, and leaving standstill 48-60h, to get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 42～55h, get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation, adjust pH is to 7.5-7.8, put 105 ℃ of sterilization 1h in the sealing bucket, for subsequent use; The intermediate of above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group is sequentially added into, add again water for injection and be diluted to full dose, stir, ultrafiltration, after 15 minutes adjust pH to 7.5～7.6 in the filter circulation of the sodium chloride of adding dosage through 0.45 μ m microporous filter membrane is housed, detection level is qualified, and medicinal liquid is embedding after 2 filters that 0.22 μ m microporous filter membrane is housed filter successively, sterilization.
2. method for preparing kidney health sodium chloride injection as claimed in claim 1 is characterized in that:
Get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, amount of water is 10 times of amounts of crude drug for the first time, after soaking 30min, boil 30min, filter, amount of water is 8 times of amounts of crude drug for the second time, boil 30min, filter, amount of water is 7 times of amounts of crude drug for the third time, boils 30min, filters, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leave standstill 48-60h, get supernatant liquid filtering to clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add 5% gelatin solution, tannin-removing, adding 95% ethanol, is 75% to containing the alcohol amount, leaves standstill 48-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 42～55h gets that supernatant liquid filtering is clear and bright and to be concentrated into relative density be 60 ℃ 1.20～1.22, adding 95% ethanol is 80% to containing the alcohol amount, leave standstill 48-60h, get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 42～55h; Get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation, adjust pH is put 105 ℃ of sterilization 1h in the sealing bucket to 7.5-7.8, and is for subsequent use; The dosage Flos Carthami, Milkvetch Root, amount of water is 10 times of amounts of crude drug for the first time, soak 30min, boil 45min, filter, amount of water is 8 times of amounts of crude drug for the second time, boil 45min, filter, amount of water is 7 times of amounts of crude drug for the third time, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, containing the alcohol amount to medicinal liquid is 70%, leaves standstill 48-60h, gets supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 4 times of amounts of medicinal liquid, cold preservation 42～55h gets supernatant liquid filtering clear and bright and be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, containing alcohol amount to medicinal liquid is 80%, and leaving standstill 48-60h, to get supernatant liquid filtering clear and bright, Recycled ethanol to relative density 60 ℃ the time 1.20～1.22, add water for injection to 2 times of amounts of medicinal liquid, cold preservation 42～55h, get supernatant liquid filtering clear and bright after, add 0.5% active carbon, boil 30min, filter, cold preservation, adjust pH is to 7.5-7.8, put 105 ℃ of sterilization 1h in the sealing bucket, for subsequent use; The intermediate of above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group is sequentially added into, add again water for injection and be diluted to full dose, stir, ultrafiltration, after 15 minutes adjust pH to 7.5～7.6 in the filter circulation of the sodium chloride of adding dosage through 0.45 μ m microporous filter membrane is housed, detection level is qualified, and medicinal liquid is embedding after 2 filters that 0.22 μ m microporous filter membrane is housed filter successively, sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110325974 CN102475759B (en) | 2010-11-30 | 2011-10-24 | Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010581858 | 2010-11-30 | ||
| CN201010581858.3 | 2010-11-30 | ||
| CN 201110325974 CN102475759B (en) | 2010-11-30 | 2011-10-24 | Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102475759A CN102475759A (en) | 2012-05-30 |
| CN102475759B true CN102475759B (en) | 2013-10-16 |
Family
ID=46088617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110325974 Active CN102475759B (en) | 2010-11-30 | 2011-10-24 | Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102475759B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107485669A (en) * | 2017-08-18 | 2017-12-19 | 广州市圆强医药科技有限公司 | Utilize the strong raw precious treatment uremic biodialysis therapy of nephrosis |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146358A (en) * | 1996-07-16 | 1997-04-02 | 成都中医药大学附属医院 | Shengkang injection solution (for nephrosis) and preparation technology |
| CN1480195A (en) * | 2003-06-09 | 2004-03-10 | 海南天元制药厂 | Formula of Chinese herbal medicine of injection and bougie for treating kidney failure as well as its preparing method |
| CN1654058A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | Medicine for treating chronic kidney failure and its preparing process |
| CN1654060A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | 'Kidney-Benefiting' glucose injection and its preparing process |
| CN1657060A (en) * | 2004-02-17 | 2005-08-24 | 吴芳 | Shenkang freeze-dried powder injection for injection and its preparation technology |
-
2011
- 2011-10-24 CN CN 201110325974 patent/CN102475759B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146358A (en) * | 1996-07-16 | 1997-04-02 | 成都中医药大学附属医院 | Shengkang injection solution (for nephrosis) and preparation technology |
| CN1480195A (en) * | 2003-06-09 | 2004-03-10 | 海南天元制药厂 | Formula of Chinese herbal medicine of injection and bougie for treating kidney failure as well as its preparing method |
| CN1654058A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | Medicine for treating chronic kidney failure and its preparing process |
| CN1654060A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | 'Kidney-Benefiting' glucose injection and its preparing process |
| CN1657060A (en) * | 2004-02-17 | 2005-08-24 | 吴芳 | Shenkang freeze-dried powder injection for injection and its preparation technology |
Non-Patent Citations (2)
| Title |
|---|
| 崔俊起等.肾康注射液对早期糖尿病肾病的治疗观察.《中国误诊学杂志》.2008,第08卷(第09期),2096-2097. |
| 肾康注射液对早期糖尿病肾病的治疗观察;崔俊起等;《中国误诊学杂志》;20080325;第08卷(第09期);2096-2097 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102475759A (en) | 2012-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102771607A (en) | Herbal tea capable of eliminating excess fire and preparation method of herbal tea | |
| CN102197877A (en) | Health care beverage | |
| CN102475764A (en) | Preparation method of Shenkang injection | |
| CN104958564B (en) | Dendrobium candidum oral solution and preparation method thereof | |
| CN102475756B (en) | Shenkang injection compound preparation for treating chronic renal failure and preparation method of Shenkang injection compound preparation | |
| CN102475759B (en) | Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection | |
| CN102475762B (en) | Shenkang oral liquid compound preparation for treating chronic renal failure and preparation method of Shenkang oral liquid compound preparation | |
| CN108450597A (en) | A kind of plant compound tea beverage | |
| CN102475753B (en) | Kidney-health patch for treating chronic renal failure and preparation method thereof | |
| CN102475760B (en) | Kidney-health compound preparation for treating chronic renal failure and preparation method thereof | |
| CN107582648A (en) | It is a kind of to be used to treat Chinese medicine preparation of CKD and preparation method thereof | |
| CN107412552B (en) | Eye protection liquid capable of treating myopia of children and preparation method thereof | |
| CN102475763B (en) | Shenkang dripping pill for treating chronic renal failure and preparation method thereof | |
| CN101897728A (en) | Preparation method for traditional Chinese medicine earthworm injection | |
| CN102475754B (en) | Shenkang soft capsule for treating chronic renal failure and preparation method of Shenkang soft capsule | |
| CN104257755A (en) | Composition with effect of treating diabetes as well as preparation method and application of composition | |
| CN101019949B (en) | Qingkailing preparation for great transfusion and its preparation process | |
| CN104127656A (en) | Trichosanthis Radix hypoglycemic capsule and preparation method thereof | |
| CN103767023A (en) | Blood glucose reducing healthcare drink and preparation method thereof | |
| CN105267722A (en) | Cough relieving and sputum removing Chinese patent medicine preparation and | |
| CN102631402A (en) | Astragalus mongholicus injection and preparation process thereof | |
| CN105287849B (en) | A kind of anti-radiation preparation and its preparation method and application | |
| CN102475757B (en) | Kidney-strengthening externally applied compound preparation for treating chronic renal failure and preparation method of compound preparation | |
| CN102475755B (en) | Shenkang aerosol for treating chronic renal failure and preparation method of Shenkang aerosol | |
| CN107625812A (en) | A kind of medicament group for being used to treat CKD |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |