CN107412552B - Eye protection liquid capable of treating myopia of children and preparation method thereof - Google Patents
Eye protection liquid capable of treating myopia of children and preparation method thereof Download PDFInfo
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- CN107412552B CN107412552B CN201710664804.5A CN201710664804A CN107412552B CN 107412552 B CN107412552 B CN 107412552B CN 201710664804 A CN201710664804 A CN 201710664804A CN 107412552 B CN107412552 B CN 107412552B
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Abstract
The invention provides an eye protection liquid for treating myopia of children and a preparation method thereof, wherein eyeballs of children are in a growth and development stage, and high myopia is caused along with increased learning pressure, popularization of electronic screens and reduction of outdoor activity time, and the eye protection liquid has the following beneficial effects: the eye protecting liquid of the present invention has raised ciliary muscle regulating capacity and sensitivity, capacity of relieving visual fatigue, capacity of relieving ciliary muscle spasm, capacity of improving visual function and capacity of relieving and treating myopia.
Description
Technical Field
The invention belongs to the technical field of medicine, particularly relates to ophthalmology, and more particularly relates to eye protection liquid capable of treating myopia of children, and further relates to a preparation method of the eye protection liquid.
Background
In the state of accommodation relaxation, parallel rays pass through the eye dioptric system and are focused in front of the retina, which is called myopia. Myopic eyes are also called short-sighted eyes because the eyes can only see near but not far. When the eye is at rest, parallel light from infinity refracts through the refractive system of the eye, and then the parallel light is gathered to be a focus in front of the retina, and an unclear image is formed on the retina, so that the distance vision is obviously reduced, but the near vision is normal.
The first white paper for systematic study of visual health in China, national visual health, is released today. White paper indicates that myopia has become a national disease in our country: in the population over 5 years old in China, 1 person in every 3 persons is myopia. In the general population over 5 years old, the proportion of myopia is 35.16-39.21%, the total number of patients with myopia is 4.37-4.87 billion, the proportion of high myopia is 2.33-2.47%, and the total population with high myopia is 2900-3040 ten thousand. White paper states that if effective policy intervention cannot be taken, the incidence of myopia in people over 5 years of age in China is expected to increase to 50.86% to 51.36% by 2020.
The suffering of the refractive errors of myopia, hypermetropia and the like in China shows the trend of low age. In young children, the prevalence of myopia rapidly increases with age, with an average myopia rate of 46.64% at age 6 to 15, a phenomenon that is more severe in economically developed areas.
The early and high incidence of myopia is closely related to the aggravation of eye burden of students. The two stages of "small initial rise" and "initial rise" are the stages of rapidly rising prevalence of refractive error. According to survey, the vision of students is improved to a certain extent after the period of improving the school. The bad eye using habit and environment have great influence on the incidence of myopia. Myopia can be induced by near distance eye load; increased learning stress, the popularity of electronic screens, and reduced outdoor activity times may be the most critical factors that lead to high myopia and rapid aging.
White paper also indicates that the aging of myopia is not simple like wearing a pair of glasses more, and the occurrence and the harm of myopia are irreversible. High myopia easily causes various eyeground pathological changes, and causes serious permanent visual function damage. Heritability and familial aggregation of myopia can affect the future population quality in our country.
In addition, the economic burden of fitting glasses is not low: in the myopia population above 5 years old in 2012, the number of matched glasses is between 2.32 and 2.63 hundred million people, the number of matched glasses of the matched glasses population is between 1.02 and 1.17 hundred million glasses per year, and the annual cost of matched glasses is between 454.48 and 532.47 million yuan.
The long-time short-distance work with eyes can cause excessive adjustment and aggregation, cause the decline of the eye adjusting function and the spasm of ciliary muscles, promote the inner and outer muscles of the eyes to press eyeballs to prolong the axis of the eyes, is an important source for the generation and development of myopia, and brings serious threats to the study, life and physical and mental health of the vast teenagers and children due to the vision problem.
Disclosure of Invention
The invention aims to provide the eye protection liquid for treating the myopia of the children, relieve the asthenopia, improve the visual function, effectively relieve and treat the myopia of the children and improve the visual effect.
In order to solve the technical problems, the technical scheme of the invention is as follows:
an eye protection solution capable of treating myopia of children is prepared from the following raw materials by weight:
200g of fresh sheep eye, 400g of fresh sheep liver, 600g of rhizoma acori graminei, 500g of coptis chinensis, 800g of dandelion, 1000g of angelica sinensis, 1000g of polygala tenuifolia, 700g of prepared rehmannia root, 500g of Chinese date, 600g of radix pseudostellariae, 400g of wolfberry fruit, 600g of ligusticum wallichii, 700g of poria with hostwood, 300g of fructus forsythiae, 800g of fructus gardeniae, 500g of scutellaria baicalensis, 300g of radix ophiopogonis, 1000g of fructus broussonetiae, 800g of longan with core, 400g of chrysanthemum, 500g of radix paeoniae alba, 500g of radix adenophorae, 800g of semen cassiae, 300g of buddleja officinalis, 500g of equisetum, 200g of periostracum cicada.
The technical problem to be solved by the invention is to provide a preparation method of an eye protection solution for treating children myopia, the eye protection solution can relieve asthenopia, improve visual function, effectively relieve and treat children myopia, and improve visual effect.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a preparation method of eye protection liquid capable of treating children myopia is prepared from the following raw materials by weight:
200g of fresh sheep eyes, 400g of fresh sheep liver, 600g of rhizoma acori graminei, 500g of coptis chinensis, 1000g of angelica sinensis, 700g of prepared rehmannia root, 600g of radix pseudostellariae, 600g of ligusticum wallichii, 300g of fructus forsythiae, 800g of fructus gardeniae, 500g of scutellaria baicalensis, 300g of radix ophiopogonis, 1000g of fructus broussonetiae, 800g of longan with core, 400g of chrysanthemum, 500g of radix paeoniae alba, 500g of radix adenophorae, 800g of semen cassiae, 300g of butterflybush flower, 500g of horsetail, 200g of periostracum cicada and 400;
the preparation method comprises the following steps:
cutting fresh hepar Caprae Seu Ovis, washing with distilled water repeatedly to remove blood clot, and draining to obtain crushed hepar Caprae Seu Ovis; washing fresh sheep eye with distilled water, draining, and cutting to obtain broken sheep eye; uniformly mixing the crushed sheep liver and the crushed sheep eye to obtain crushed substances, adding 500ml of hydrochloric acid with the mass fraction of 20% into each kilogram of the crushed substances, stirring while adding, carrying out acid leaching for 15min, placing the acidolysis substances on a water bath to boil, maintaining for 2h, repeatedly stirring to fully carry out acidolysis, then adjusting the pH value to 7.3 by using sodium hydroxide, adjusting the pH value to 6.2 by using hydrochloric acid with the molar concentration of 1mol/L, filtering, decolorizing by using activated carbon, carrying out decarburization filtering, refrigerating at the temperature of 3-5 ℃ for 48h after cooling, placing the mixture in a No. 6 vertical melting funnel for sterilization and filtration to obtain a preparation solution I, and sealing and storing for later use;
adding water 10 times of rhizoma Acori Graminei into rhizoma Acori Graminei, heating and boiling, steam distilling, collecting distillate 4 times of rhizoma Acori Graminei, and collecting rhizoma Acori Graminei residue and residual water solution; adding distilled water 1.5 times of rhizoma Acori Graminei weight into the distillate, mixing, redistilling, collecting rhizoma Acori Graminei distillate 2 times of rhizoma Acori Graminei weight, and sealing for storage;
akg, pulverizing rhizoma Coptidis, radix Pseudostellariae, radix rehmanniae Preparata, radix Angelicae sinensis and rhizoma Ligustici Chuanxiong, mixing, soaking in 60 vol% ethanol for 24 hr, percolating at a speed of 35ml/50 kg/min until the weight of percolate reaches 5Akg, and collecting percolate;
adding fructus forsythiae, fructus gardeniae, scutellaria baicalensis, radix ophiopogonis, fructus broussonetiae, longan with core, chrysanthemum, radix paeoniae alba, radix adenophorae, semen cassiae, buddleja officinalis, equisetum hiemalis, and notopterygium root Bkg by total weight, adding 5Bkg weight of water into a tank, soaking at 60 ℃ for 2 hours, filtering to obtain filtrate I, and concentrating the filtrate I under reduced pressure to 0.5Bkg to obtain concentrated solution I for later use; adding 4Bkg weight parts of water into the residue, mixing with rhizoma Acori Graminei residue and the rest water solution, boiling for 30min, and filtering to obtain filtrate II; adding 3Bkg weight parts of water into the residue, boiling for 30min, and filtering to obtain filtrate III; mixing the filtrate II and the filtrate III, and concentrating under reduced pressure to 0.5Bkg to obtain concentrated solution II for use;
mixing the concentrated solution I and the concentrated solution II, concentrating under reduced pressure to obtain concentrated juice, cooling, mixing with the percolate, adding 95 vol% ethanol under stirring, adjusting ethanol content to 50% (that is, ethanol content is 50 vol%), standing for 12 hr, vacuum filtering, recovering ethanol from the filtrate, and concentrating under reduced pressure to 0.5 (A + B) kg to obtain concentrated solution III;
slowly pouring the concentrated solution III into 95 vol% ethanol while stirring, adjusting the alcohol content to 60%, standing for 24h, suction filtering, recovering ethanol from the filtrate, and concentrating under reduced pressure to 0.5 (A + B) kg to obtain concentrated solution IV;
slowly pouring the concentrated solution IV into 95 volume percent ethanol, stirring while adding, adjusting the alcohol content to 75%, standing for 24h, performing suction filtration, recovering ethanol from the filtrate, concentrating under reduced pressure to 0.33 (A + B) kg, volatilizing the ethanol, and cooling to obtain a concentrated solution V;
adding distilled water into the concentrated solution V to A + Bkg, stirring uniformly, decolorizing with activated carbon, filtering, evaporating the filtrate, and concentrating to 0.2 (A + B) kg to obtain concentrated solution VI;
mixing the rhizoma Acori Graminei distillate and the concentrated solution VI, adjusting pH to 7.0 with 1mol/L sodium hydroxide, standing for 48h, vacuum filtering, sterilizing the filtrate to obtain a solution II, and sealing for storage;
slowly pouring the preparation solution I into the preparation solution II, stirring while adding, and standing for 24h to obtain eye-protecting solution.
The technical problem to be solved by the invention is to provide a preparation method of an eye protection solution for treating children myopia, the eye protection solution can relieve asthenopia, improve visual function, effectively relieve and treat children myopia, and improve visual effect.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a preparation method of eye protection liquid capable of treating children myopia is prepared from the following raw materials by weight:
200g of fresh sheep eye, 400g of fresh sheep liver, 600g of rhizoma acori graminei, 500g of coptis chinensis, 800g of dandelion, 1000g of angelica, 1000g of polygala tenuifolia, 700g of prepared rehmannia root, 500g of Chinese date, 600g of radix pseudostellariae, 400g of wolfberry fruit, 600g of ligusticum wallichii, 700g of poria with hostwood, 300g of fructus forsythiae, 800g of fructus gardeniae, 500g of scutellaria baicalensis, 300g of radix ophiopogonis, 1000g of fructus broussonetiae, 800g of longan with core, 400g of chrysanthemum, 500g of radix paeoniae alba, 500g of radix adenophorae, 800g of semen cassiae, 300g of buddleja officinalis, 500g of equisetum, 200g of periostracum cicada;
the preparation method comprises the following steps:
cutting fresh hepar Caprae Seu Ovis, washing with distilled water repeatedly to remove blood clot, and draining to obtain crushed hepar Caprae Seu Ovis; washing fresh sheep eye with distilled water, draining, and cutting to obtain broken sheep eye; uniformly mixing the crushed sheep liver and the crushed sheep eye to obtain crushed substances, adding 500ml of hydrochloric acid with the mass fraction of 20% into each kilogram of the crushed substances, stirring while adding, carrying out acid leaching for 15min, placing the acidolysis substances on a water bath to boil, maintaining for 2h, repeatedly stirring to fully carry out acidolysis, then adjusting the pH value to 7.3 by using sodium hydroxide, adjusting the pH value to 6.2 by using hydrochloric acid with the molar concentration of 1mol/L, filtering, decolorizing by using activated carbon, carrying out decarburization filtering, refrigerating at the temperature of 3-5 ℃ for 48h after cooling, placing the mixture in a No. 6 vertical melting funnel for sterilization and filtration to obtain a preparation solution I, and sealing and storing for later use;
adding water 10 times of rhizoma Acori Graminei into rhizoma Acori Graminei, heating and boiling, steam distilling, collecting distillate 4 times of rhizoma Acori Graminei, and collecting rhizoma Acori Graminei residue and residual water solution; adding distilled water 1.5 times of rhizoma Acori Graminei weight into the distillate, mixing, redistilling, collecting rhizoma Acori Graminei distillate 2 times of rhizoma Acori Graminei weight, and sealing for storage;
akg, pulverizing rhizoma Coptidis, radix Pseudostellariae, radix rehmanniae Preparata, radix Angelicae sinensis and rhizoma Ligustici Chuanxiong, mixing, soaking in 60 vol% ethanol for 24 hr, percolating at a speed of 35ml/50 kg/min until the weight of percolate reaches 5Akg, and collecting percolate;
adding fructus forsythiae, fructus gardeniae, scutellaria baicalensis, radix ophiopogonis, fructus broussonetiae, longan with core, chrysanthemum, radix paeoniae alba, radix adenophorae, semen cassiae, buddleja officinalis, equisetum hiemalis, and notopterygium root Bkg by total weight, adding 5Bkg weight of water into a tank, soaking at 60 ℃ for 2 hours, filtering to obtain filtrate I, and concentrating the filtrate I under reduced pressure to 0.5Bkg to obtain concentrated solution I for later use; adding 4Bkg weight parts of water into the residue, mixing with rhizoma Acori Graminei residue and the rest water solution, boiling for 30min, and filtering to obtain filtrate II; adding 3Bkg weight parts of water into the residue, boiling for 30min, and filtering to obtain filtrate III; mixing the filtrate II and the filtrate III, and concentrating under reduced pressure to 0.5Bkg to obtain concentrated solution II for use;
mixing the concentrated solution I and the concentrated solution II, concentrating under reduced pressure to obtain concentrated juice, cooling, mixing with the percolate, adding 95 vol% ethanol under stirring, adjusting ethanol content to 50% (that is, ethanol content is 50 vol%), standing for 12 hr, vacuum filtering, recovering ethanol from the filtrate, and concentrating under reduced pressure to 0.5 (A + B) kg to obtain concentrated solution III;
slowly pouring the concentrated solution III into 95 vol% ethanol while stirring, adjusting the alcohol content to 60%, standing for 24h, suction filtering, recovering ethanol from the filtrate, and concentrating under reduced pressure to 0.5 (A + B) kg to obtain concentrated solution IV;
slowly pouring the concentrated solution IV into 95 volume percent ethanol, stirring while adding, adjusting the alcohol content to 75%, standing for 24h, performing suction filtration, recovering ethanol from the filtrate, concentrating under reduced pressure to 0.33 (A + B) kg, volatilizing the ethanol, and cooling to obtain a concentrated solution V;
adding distilled water into the concentrated solution V to A + Bkg, stirring uniformly, decolorizing with activated carbon, filtering, evaporating the filtrate, and concentrating to 0.2 (A + B) kg to obtain concentrated solution VI;
mixing the rhizoma Acori Graminei distillate and the concentrated solution VI, adjusting pH to 7.0 with 1mol/L sodium hydroxide, standing for 48h, vacuum filtering, sterilizing the filtrate to obtain a solution II, and sealing for storage;
ckg total weight of herba asari, herba Taraxaci, cortex Phellodendri, cortex et radix Polygalae, fructus Jujubae, fructus Lycii and Poria, adding herba asari, herba Taraxaci, cortex Phellodendri, cortex et radix Polygalae, fructus Jujubae, fructus Lycii and Poria into a tank, adding 8Ckg weight of water, boiling for 1h, filtering to obtain decoction I, adding 6Ckg weight of water into the residue, boiling for 1h, filtering to obtain decoction II, mixing the decoction I and the decoction II to obtain a mixed solution, calcining Galamina with charcoal fire to red, immediately quenching into the mixed solution, soaking for 2h, taking out Galamina, calcining with charcoal fire to red, immediately quenching into the mixed solution, calcining and quenching for 7 times, grinding calamine to obtain calamine powder, adding the calamine powder into the mixed solution, boiling for 30min, filtering, concentrating the filtrate under reduced pressure to Ckg, decolorizing with activated carbon, performing suction filtration, adjusting pH to 7.0 with sodium hydroxide with the molar concentration of 1mol/L, standing for 48h, performing suction filtration, sterilizing the filtrate to obtain a prepared solution III, and sealing and storing for later use;
and mixing the solution I, the solution II and the solution III, and standing for 24h to obtain eye-protecting solution.
The eyeball of the child is in the growth and development stage, and the myopia is caused to be high along with the aggravation of the learning pressure, the popularization of the electronic screen and the reduction of the outdoor activity time, and the invention has the beneficial effects that: the eye protecting liquid of the present invention has raised ciliary muscle regulating capacity and sensitivity, capacity of relieving visual fatigue, capacity of relieving ciliary muscle spasm, capacity of improving visual function and capacity of relieving and treating myopia.
Detailed Description
Papermulberry fruit: cold in nature, sweet in taste, tonifying kidney, removing liver heat, improving eyesight, and promoting urination;
fructus forsythiae: bitter and cool, clear heat, remove toxicity, dissipate nodulation and resolve swelling.
Radix ophiopogonis: sweet, slightly bitter and slightly cold, moistening lung and clearing heart;
coptis chinensis: bitter taste, cold nature, purging fire, removing toxicity, blood-shot eyes;
dandelion: bitter and sweet taste and cold property, can clear away heat and toxic materials, promote the circulation of the striae and muscles and promote the flow of qi and blood;
chrysanthemum: sweet and bitter taste, slightly cold nature, wind-dispersing, heat-clearing, liver-clearing, eyesight-improving, detoxifying and inflammation-diminishing;
poria with hostwood: sweet and light taste, slightly warm nature, good appetite and intelligence, spleen strengthening and mind calming;
ligusticum wallichii: pungent and warm in flavor, activate blood and promote qi circulation, relieve depression and dredge;
scutellaria baicalensis: bitter taste and cold nature, and can clear heat, dry dampness, purge fire and remove toxicity;
cicada shell: no odor, light taste, dispelling pathogenic wind heat, promoting eruption, relieving sore throat, removing nebula, improving eyesight, dispelling pathogenic wind, and relieving spasm;
b, horsetail: sweet and bitter taste, mild nature, entering lung and liver meridians, dispelling wind and heat, improving eyesight and removing nebula;
butterflybush flower: dispelling pathogenic wind, cooling blood, moistening liver, improving eyesight;
asarum: expelling wind, dispelling cold, promoting diuresis, and inducing resuscitation;
phellodendron bark: bitter taste, cold nature, clearing heat and drying dampness, purging fire and removing toxicity;
chinese angelica: sweet, pungent, warm, tonify blood and regulate blood;
gardenia: protecting liver and benefiting gallbladder;
polygala root: bitter, pungent and warm, tranquilization and intelligence development, and depression relieving;
parching semen Cassiae: bitter, sweet and cool in nature, and has the effects of clearing liver fire, dispelling wind-damp, tonifying kidney and improving eyesight;
grassleaf sweelflag rhizome: refreshing mind, regulating qi, promoting blood circulation, and dispelling pathogenic wind;
prepared rehmannia root: sweet and warm. Enter liver and kidney meridians, nourish blood and yin, supplement essence and fill marrow;
white peony root: pacify liver, nourish blood, astringe yin to check sweating.
Root of straight ladybell: sweet and slightly bitter, nourishing, dispelling cold and heat, clearing lung-heat;
wolfberry fruit: sweet and neutral, enter liver and kidney meridians, nourish liver and kidney, replenish vital essence and improve eyesight,
longan: warm in nature and sweet in taste, and can tonify heart and spleen, and replenish qi and blood;
chinese date: sweet in taste and warm in nature, enters spleen and stomach channels, tonifies middle-jiao and qi, nourishes blood and soothes nerves;
radix pseudostellariae: sweet, slightly bitter and neutral in nature, and has the effects of replenishing qi to invigorate the spleen, promoting the production of body fluid and moistening the lung;
fresh sheep eyes: tonifying kidney qi, tonifying body, stimulating appetite, strengthening body constitution, and improving eyesight;
fresh sheep liver: replenishing blood, tonifying liver, tomorrow;
calamine: remove toxicity, improve vision, remove nebula, astringe dampness, relieve itching and heal wound.
An eye protection liquid capable of treating myopia of children is characterized in that: the composition is prepared from the following raw materials in parts by weight:
200g of fresh sheep eye, 400g of fresh sheep liver, 600g of rhizoma acori graminei, 500g of coptis chinensis, 800g of dandelion, 1000g of angelica sinensis, 1000g of polygala tenuifolia, 700g of prepared rehmannia root, 500g of Chinese date, 600g of radix pseudostellariae, 400g of wolfberry fruit, 600g of ligusticum wallichii, 700g of poria with hostwood, 300g of fructus forsythiae, 800g of fructus gardeniae, 500g of scutellaria baicalensis, 300g of radix ophiopogonis, 1000g of fructus broussonetiae, 800g of longan with core, 400g of chrysanthemum, 500g of radix paeoniae alba, 500g of radix adenophorae, 800g of semen cassiae, 300g of buddleja officinalis, 500g of equisetum, 200g of periostracum cicada.
The first embodiment is as follows:
a preparation method of eye protection liquid capable of treating children myopia is prepared from the following raw materials by weight:
200g of fresh sheep eyes, 400g of fresh sheep liver, 600g of rhizoma acori graminei, 500g of coptis chinensis, 1000g of angelica sinensis, 700g of prepared rehmannia root, 600g of radix pseudostellariae, 600g of ligusticum wallichii, 300g of fructus forsythiae, 800g of fructus gardeniae, 500g of scutellaria baicalensis, 300g of radix ophiopogonis, 1000g of fructus broussonetiae, 800g of longan with core, 400g of chrysanthemum, 500g of radix paeoniae alba, 500g of radix adenophorae, 800g of semen cassiae, 300g of butterflybush flower, 500g of horsetail, 200g of periostracum cicada and 400;
the preparation method comprises the following steps:
cutting fresh hepar Caprae Seu Ovis, washing with distilled water repeatedly to remove blood clot, and draining to obtain crushed hepar Caprae Seu Ovis; washing fresh sheep eye with distilled water, draining, and cutting to obtain broken sheep eye; mixing crushed sheep liver and crushed sheep eye uniformly to obtain crushed material, adding diluted hydrochloric acid 500ml per kilogram of crushed material, stirring while adding, acid leaching for 15min to obtain acidolyzed material, boiling acidolyzed material in water bath, maintaining for 2 hr, repeatedly stirring to perform acidolysis, adjusting pH to 7.3 with sodium hydroxide (1N sodium hydroxide solution/1 mol/L sodium hydroxide solution), filtering to obtain fibrous tissue liquid, adjusting pH to 6.2 with 1mol/L hydrochloric acid (1N hydrochloric acid), decolorizing filtrate with activated carbon, preferably adding 0.5% activated carbon, standing for 12 hr, repeatedly filtering with activated carbon layer or boiling with 0.2% activated carbon water bath for 30min, decarbonizing, filtering to remove activated carbon, cooling, refrigerating at 3-5 deg.C for 48 hr, sterilizing and filtering with No. 6 vertical melting funnel (also can pass No. 3 vertical melting funnel, sterilizing at 100 deg.C for 30 min) to obtain preparation solution I, and sealing for storage.
Adding 10 times of water into rhizoma Acori Graminei, heating to boil, steam distilling, and collecting 4 times of distillate of rhizoma Acori Graminei, i.e. rhizoma Acori Graminei: water: the weight ratio of the distillate is 1:10: 4; mixing rhizoma Acori Graminei residue and the rest water solution (the rest part after distillation, including rhizoma Acori Graminei residue and water solution); adding 1.5 times of distilled water of the weight of the acorus gramineus into the distillate, namely the distillate: the weight ratio of the distilled water is 8: 3; mixing, redistilling, and collecting distillate 2 times of rhizoma Acori Graminei weight, which is called rhizoma Acori Graminei distillate, namely rhizoma Acori Graminei: the weight ratio of the rhizoma acori graminei distillate is 1: 2; sealing and storing for later use;
akg, pulverizing rhizoma Coptidis, radix Pseudostellariae, radix rehmanniae Preparata, radix Angelicae sinensis and rhizoma Ligustici Chuanxiong, mixing, soaking in 60 vol% ethanol for 24 hr, percolating at a speed of 35ml/50 kg/min until the weight of percolate reaches 5Akg, and collecting percolate;
bkg of the total weight of forsythia, gardenia, scutellaria, ophiopogon root, fructus broussonetiae, longan with core, chrysanthemum, white peony root, radix adenophorae, cassia seed, buddleja officinalis, horsetail, cicada shell and notopterygium root, namely, the total weight of the forsythia, gardenia, scutellaria, ophiopogon root, fructus broussonetiae, longan with core, chrysanthemum, white peony root, adenophora root, cassia seed, buddleja, horsetail, cicada shell and notopterygium root is put into a tank, 5Bkg weight of water is added into the tank, the temperature is 60 ℃ for 2 hours, the solution is filtered, preferably by double-layer gauze to obtain a filtrate I, the filtrate I is decompressed and concentrated to 0.5 Bkg; adding 4Bkg weight parts of water into the residue, mixing with rhizoma Acori Graminei residue and the rest water solution, boiling for 30min, and filtering to obtain filtrate II; adding 3Bkg weight parts of water into the residue, boiling for 30min, and filtering to obtain filtrate III; mixing the above two filtrates, mixing filtrate II and filtrate III, concentrating under reduced pressure to 0.5Bkg to obtain concentrated solution II;
mixing the above two concentrated solutions, i.e. mixing concentrated solution I and concentrated solution II, concentrating under reduced pressure to obtain concentrated juice, cooling, adding into percolate, mixing with percolate, adding 95 vol% ethanol under stirring, and regulating ethanol content to 50%, that is: adjusting the volume percentage content of ethanol in the solution to 50%, precipitating precipitate, standing for 12h, suction-filtering, preferably with silk cloth, discarding the precipitate, collecting filtrate, recovering ethanol from the filtrate, and concentrating under reduced pressure to 0.5 (A + B) kg to obtain concentrated solution III;
slowly pouring the concentrated solution III into 95% ethanol with volume percentage, stirring while adding, adjusting the alcohol content to 60%, precipitating, standing for 24h, suction-filtering, preferably using silk cloth to suction-filter, removing precipitate, collecting filtrate, recovering ethanol from the filtrate, and concentrating under reduced pressure to 0.5 (A + B) kg to obtain concentrated solution IV;
slowly pouring the concentrated solution IV into 95% ethanol with volume percentage, stirring while adding, adjusting the alcohol content to 75%, standing for 24h, performing suction filtration, preferably using silk fabric, collecting filtrate, recovering ethanol from the filtrate, concentrating under reduced pressure to 0.33 (A + B) kg, volatilizing the ethanol, and cooling to obtain concentrated solution V;
adding distilled water into the concentrated solution V until the volume ratio of A to B is A + Bkg, stirring uniformly, adding activated carbon, decoloring by using activated carbon, preferably adding 0.5% of activated carbon, standing for 24h or repeatedly filtering through an activated carbon layer, performing suction filtration, preferably performing suction filtration by using a No. 3 filter stick, collecting filtrate, and evaporating and concentrating the filtrate to 0.2 (A + B) kg to obtain a concentrated solution VI;
mixing the rhizoma Acori Graminei distillate and the concentrated solution VI, adjusting pH to 7.0 with 1mol/L sodium hydroxide (i.e. 1N sodium hydroxide solution), standing for 48h, suction-filtering, preferably with No. 3 filter stick, collecting filtrate, sterilizing the filtrate to obtain a solution II, and sealing for storage;
slowly pouring the preparation solution I into the preparation solution II, stirring while adding, and standing for 24h to obtain eye-protecting solution.
The second embodiment is as follows:
a preparation method of eye protection liquid capable of treating children myopia is prepared from the following raw materials by weight:
200g of fresh sheep eye, 400g of fresh sheep liver, 600g of rhizoma acori graminei, 500g of coptis chinensis, 800g of dandelion, 1000g of angelica, 1000g of polygala tenuifolia, 700g of prepared rehmannia root, 500g of Chinese date, 600g of radix pseudostellariae, 400g of wolfberry fruit, 600g of ligusticum wallichii, 700g of poria with hostwood, 300g of fructus forsythiae, 800g of fructus gardeniae, 500g of scutellaria baicalensis, 300g of radix ophiopogonis, 1000g of fructus broussonetiae, 800g of longan with core, 400g of chrysanthemum, 500g of radix paeoniae alba, 500g of radix adenophorae, 800g of semen cassiae, 300g of buddleja officinalis, 500g of equisetum, 200g of periostracum cicada;
the preparation method comprises the following steps:
cutting fresh hepar Caprae Seu Ovis, washing with distilled water repeatedly to remove blood clot, and draining to obtain crushed hepar Caprae Seu Ovis; washing fresh sheep eye with distilled water, draining, and cutting to obtain broken sheep eye; uniformly mixing the crushed sheep liver and the crushed sheep eye to obtain crushed substances, adding 500ml of hydrochloric acid with the mass fraction of 20% into each kilogram of the crushed substances, stirring while adding, carrying out acid leaching for 15min, placing the acidolysis substances on a water bath to boil, maintaining for 2h, repeatedly stirring to fully carry out acidolysis, then adjusting the pH value to 7.3 by using sodium hydroxide, adjusting the pH value to 6.2 by using hydrochloric acid with the molar concentration of 1mol/L, filtering, decolorizing by using activated carbon, carrying out decarburization filtering, refrigerating at the temperature of 3-5 ℃ for 48h after cooling, placing the mixture in a No. 6 vertical melting funnel for sterilization and filtration to obtain a preparation solution I, and sealing and storing for later use;
adding water 10 times of rhizoma Acori Graminei into rhizoma Acori Graminei, heating and boiling, steam distilling, collecting distillate 4 times of rhizoma Acori Graminei, and collecting rhizoma Acori Graminei residue and residual water solution; adding distilled water 1.5 times of rhizoma Acori Graminei weight into the distillate, mixing, redistilling, collecting rhizoma Acori Graminei distillate 2 times of rhizoma Acori Graminei weight, and sealing for storage;
akg, pulverizing rhizoma Coptidis, radix Pseudostellariae, radix rehmanniae Preparata, radix Angelicae sinensis and rhizoma Ligustici Chuanxiong, mixing, soaking in 60 vol% ethanol for 24 hr, percolating at a speed of 35ml/50 kg/min until the weight of percolate reaches 5Akg, and collecting percolate;
adding fructus forsythiae, fructus gardeniae, scutellaria baicalensis, radix ophiopogonis, fructus broussonetiae, longan with core, chrysanthemum, radix paeoniae alba, radix adenophorae, semen cassiae, buddleja officinalis, equisetum hiemalis, and notopterygium root Bkg by total weight, adding 5Bkg weight of water into a tank, soaking at 60 ℃ for 2 hours, filtering to obtain filtrate I, and concentrating the filtrate I under reduced pressure to 0.5Bkg to obtain concentrated solution I for later use; adding 4Bkg weight parts of water into the residue, mixing with rhizoma Acori Graminei residue and the rest water solution, boiling for 30min, and filtering to obtain filtrate II; adding 3Bkg weight parts of water into the residue, boiling for 30min, and filtering to obtain filtrate III; mixing the filtrate II and the filtrate III, and concentrating under reduced pressure to 0.5Bkg to obtain concentrated solution II for use;
mixing the concentrated solution I and the concentrated solution II, concentrating under reduced pressure to obtain concentrated juice, cooling, mixing with the percolate, adding 95 vol% ethanol under stirring, adjusting ethanol content to 50% (that is, ethanol content is 50 vol%), standing for 12 hr, vacuum filtering, recovering ethanol from the filtrate, and concentrating under reduced pressure to 0.5 (A + B) kg to obtain concentrated solution III;
slowly pouring the concentrated solution III into 95 vol% ethanol while stirring, adjusting the alcohol content to 60%, standing for 24h, suction filtering, recovering ethanol from the filtrate, and concentrating under reduced pressure to 0.5 (A + B) kg to obtain concentrated solution IV;
slowly pouring the concentrated solution IV into 95 volume percent ethanol, stirring while adding, adjusting the alcohol content to 75%, standing for 24h, performing suction filtration, recovering ethanol from the filtrate, concentrating under reduced pressure to 0.33 (A + B) kg, volatilizing the ethanol, and cooling to obtain a concentrated solution V;
adding distilled water into the concentrated solution V to A + Bkg, stirring uniformly, decolorizing with activated carbon, filtering, evaporating the filtrate, and concentrating to 0.2 (A + B) kg to obtain concentrated solution VI;
mixing the rhizoma Acori Graminei distillate and the concentrated solution VI, adjusting pH to 7.0 with 1mol/L sodium hydroxide, standing for 48h, vacuum filtering, sterilizing the filtrate to obtain a solution II, and sealing for storage;
ckg total weight of herba asari, herba Taraxaci, cortex Phellodendri, cortex et radix Polygalae, fructus Jujubae, fructus Lycii and Poria are added into a tank, water 8Ckg weight is added, boiling for 1h, filtering to obtain decoction I, water 6Ckg weight is added to the residue, boiling for 1h, filtering to obtain decoction II, decoction I and decoction II are combined to obtain mixed solution, calamine is calcined with charcoal fire to clear red, the mixed solution is immediately quenched, after soaking for 2h, calamine is taken out and calcined with charcoal fire to clear red, the mixed solution is immediately quenched, then calcined and quenched for 7 times, calamine is ground to obtain calamine powder, the calamine powder is added into the mixed solution, boiling for 30min, filtering, concentrating the filtrate under reduced pressure to Ckg, decolorizing with active carbon, preferably adding 0.5% active carbon, standing for 24h or repeatedly filtering through an active carbon layer, filtering, adjusting pH to 7.0 with sodium hydroxide with molar concentration of 1mol/L, standing for 48h, performing suction filtration, sterilizing the filtrate to obtain a preparation liquid III, and sealing and storing for later use;
and mixing the solution I, the solution II and the solution III, and standing for 24h to obtain eye-protecting solution.
The eyeball of the child is in the growth and development stage, and the myopia is caused to be high along with the aggravation of the learning pressure, the popularization of the electronic screen and the reduction of the outdoor activity time. The eye protection solution prepared by the invention has good treatment effect in clinical application, the effective rate of relieving and treating myopia reaches 95.6 percent by using the eye protection solution prepared by the preparation method of the embodiment of the invention, and the curative effect is illustrated as follows:
the cases are as follows:
history, sex: female, ethnic group: han, age: when the eyes of a 9-year-old patient read in the early autumn school in Qinhuang island city and a double-eye myopia patient, the patient wears glasses for more than half a year, and after examination, the eyes are 200 degrees myopic, 300 degrees myopic and 50 degrees astigmatic, the eye protection liquid is dripped on the eyes, and the eye protection liquid is forbidden to be spicy during treatment. After 12 days of treatment of one course, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal condition after 36 days of treatment of three courses.
Chen somewhere, sex: female, ethnic group: han, age: when the eyes of the 9 year old are read in the primary schools of Xiaogao village and high school in Qinhuang island, and the myopia patients with two eyes wear glasses for 3 months, the eyes are checked to be myopic 150 degrees for the left eye, myopic 200 degrees for the right eye and astigmatic 25 degrees, and the eye protection liquid is dripped on the eyes, so that the eyes are prohibited from being spicy during treatment. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal state after 12 days of treatment.
Jia somebody, sex: male, national: han, age: after the 7 year old, the patient reads from the first primary school in the development area of Qinhuang island city and wears glasses for one year, and the eye protection liquid is dropped on eyes to avoid acridity during treatment after the examination of 230 degrees of myopia of the left eye, 200 degrees of myopia of the right eye and 25 degrees of astigmatism. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal state after 24 days of treatment.
Guo, sex: male, national: hui, age: after the people are 15 years old, the people read in the fourth school in Qinhuang island, and the myopia patients with two eyes wear the glasses for more than two years, and the eyes are checked to have 300 degrees of myopia for the left eye, 300 degrees of myopia for the right eye and 75 degrees of astigmatism, and the eye protection liquid is dripped on the eyes, so that the people are prohibited from being spicy during treatment. After 12 days of treatment of one course, the vision is improved, and then the five courses of treatment of 60 days are taken, the vision is obviously improved, and the astigmatism tends to be normal.
Certain Zhao, sex: male, national: han, age: when the eyes of a patient are 10 years old, the patient reads from the primary schools of Xiaogao village and high school in Qinhuang island city and wears glasses for one year, and after the examination, the eyes of the patient are 250 degrees myopic in the left eye, 300 degrees myopic in the right eye and 75 degrees astigmatic, the eye protection liquid is dripped on the eyes, and the patient is prohibited from being spicy during treatment. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and the vision of the left and right eyes basically reaches the normal state after four treatment courses of administration for 48 days.
Liu somebody, gender: male, national: han, age: when the eyes of the 9 year old are read in the high and small villages and primary schools in Qinhuang island city and the myopia patients with two eyes wear glasses for more than half a year, the eyes are inspected to have myopia 150 degrees for the left eye, myopia 200 degrees for the right eye and astigmatism 50 degrees, the eyes are dripped on the eyes, and the eyes are prevented from being spicy during treatment. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal state after 12 days of treatment.
Yao chi, sex: female, ethnic group: han, age: after 12 years old, the patient read from the national institute of Zizhai in Qinhuang island, and who suffered from myopia at both eyes, worn glasses for more than one year, examined to see that the left eye is myopic at 220 degrees, the right eye is myopic at 250 degrees, and astigmatism is 50 degrees. The eye-protecting liquid is dripped on eyes, and pungent and spicy food is avoided during treatment. After 12 days of treatment of one course, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal condition after 36 days of treatment of three courses.
Von, sex: female, ethnic group: han, age: after the 7 year old, the patient reads from the first primary school in the development area of Qinhuang island city and wears glasses for one year, and the eye protection liquid is dripped on eyes to avoid acridity during treatment after the examination of 200 degrees of myopia of the left eye, 200 degrees of myopia of the right eye and 50 degrees of astigmatism. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal state after 24 days of treatment.
Horse, sex: male, national: han, age: when the eye protection liquid is read in West Zhangzhuang primary school in Qinhuang island city at age 8, and patients with myopia of two eyes wear glasses for one year, the eye protection liquid is dripped at eyes after examination, wherein the eyes are 200 degrees myopic in the left eye, 250 degrees myopic in the right eye and 75 degrees astigmatic, and pungency is avoided in the treatment. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal state after 24 days of treatment.
Some of yao, sex: male, national: han, age: when the patient is 12 years old, the patient reads from the sixth primary school in the development area of Qinhuang island city, wears glasses for two years, and inspects that the patient has 150 degrees of myopia in the left eye, 150 degrees of myopia in the right eye and 50 degrees of astigmatism, the eye protection liquid is dripped on the eyes, and the patient is prohibited to be spicy during treatment. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal state after 12 days of treatment.
Zhao, sex: female, ethnic group: han, age: after the patient is 7 years old, the patient reads from Donghua Li primary school in Qinhua City, Qinhuang island, wears glasses for 4 months, and inspects that the eye-protecting liquid is 200 degrees for the left eye, 250 degrees for the right eye and 50 degrees for astigmatism, and is dropped on the eyes to avoid pungency in treatment. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal state after 24 days of treatment.
Some of the animals, sex: male, national: han, age: when the patient is 9 years old, the patient reads from the first primary school in the development area of Qinhuang island city and wears glasses for one year, and after the examination, the patient has 100 degrees of myopia in the left eye, 150 degrees of myopia in the right eye and 50 degrees of astigmatism, the eye protection liquid is dripped on the eyes, and the patient is prohibited to be spicy during treatment. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal state after 12 days of treatment.
Lie, sex: male, national: han, age: when the patient is 7 years old, the patient reads from the east-middle school of bridge in Qinhuang island city and wears the glasses for one year, and the eye protection liquid is dripped on eyes to avoid acridity during treatment after the examination of 200 degrees of myopia of the left eye, 240 degrees of myopia of the right eye and 75 degrees of astigmatism of the right eye. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal state after 24 days of treatment.
Wu-chi, sex: female, ethnic group: han, age: when the eye protection liquid is read in the established middle and primary schools in Qinhuang island city and the myopia patients with two eyes at age of 8, the eyes are worn for half a year, and after the eye protection liquid is inspected, the eyes are at 150 degrees for myopia, 250 degrees for myopia and 50 degrees for astigmatism, the eye protection liquid is dripped on the eyes, and the pungency is avoided in the treatment. After 12 days of treatment, the vision is obviously improved, the astigmatism tends to be normal, and then the vision of the left and right eyes basically reaches the normal state after 24 days of treatment.
The effective rate of the eye protection liquid prepared by the second preparation method of the embodiment of the invention for relieving and treating myopia reaches 98 percent. The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various changes and modifications can be made without departing from the inventive concept of the present invention, and these changes and modifications are all within the scope of the present invention.
Claims (1)
1. A preparation method of eye protection liquid capable of treating myopia of children is characterized by comprising the following steps: the medicine is prepared from the following raw materials in parts by weight:
200g of fresh sheep eye, 400g of fresh sheep liver, 600g of rhizoma acori graminei, 500g of coptis chinensis, 800g of dandelion, 1000g of angelica, 1000g of polygala tenuifolia, 700g of prepared rehmannia root, 500g of Chinese date, 600g of radix pseudostellariae, 400g of wolfberry fruit, 600g of ligusticum wallichii, 700g of poria with hostwood, 300g of fructus forsythiae, 800g of fructus gardeniae, 500g of scutellaria baicalensis, 300g of radix ophiopogonis, 1000g of fructus broussonetiae, 800g of longan with core, 400g of chrysanthemum, 500g of radix paeoniae alba, 500g of radix adenophorae, 800g of semen cassiae, 300g of buddleja officinalis, 500g of equisetum, 200g of periostracum cicada;
the preparation method comprises the following steps:
cutting fresh hepar Caprae Seu Ovis, washing with distilled water repeatedly to remove blood clot, and draining to obtain crushed hepar Caprae Seu Ovis; washing fresh sheep eye with distilled water, draining, and cutting to obtain broken sheep eye; uniformly mixing the crushed sheep liver and the crushed sheep eye to obtain crushed substances, adding 500ml of hydrochloric acid with the mass fraction of 20% into each kilogram of the crushed substances, stirring while adding, carrying out acid leaching for 15min, placing the acidolysis substances on a water bath to boil, maintaining for 2h, repeatedly stirring to fully carry out acidolysis, then adjusting the pH value to 7.3 by using sodium hydroxide, adjusting the pH value to 6.2 by using hydrochloric acid with the molar concentration of 1mol/L, filtering, decolorizing by using activated carbon, carrying out decarburization filtering, refrigerating at the temperature of 3-5 ℃ for 48h after cooling, placing the mixture in a No. 6 vertical melting funnel for sterilization and filtration to obtain a preparation solution I, and sealing and storing for later use;
adding water 10 times of rhizoma Acori Graminei into rhizoma Acori Graminei, heating and boiling, steam distilling, collecting distillate 4 times of rhizoma Acori Graminei, and collecting rhizoma Acori Graminei residue and residual water solution; adding distilled water 1.5 times of rhizoma Acori Graminei weight into the distillate, mixing, redistilling, collecting rhizoma Acori Graminei distillate 2 times of rhizoma Acori Graminei weight, and sealing for storage;
akg, pulverizing rhizoma Coptidis, radix Pseudostellariae, radix rehmanniae Preparata, radix Angelicae sinensis and rhizoma Ligustici Chuanxiong, mixing, soaking in 60 vol% ethanol for 24 hr, percolating at a speed of 35ml/50 kg/min until the weight of percolate reaches 5Akg, and collecting percolate;
adding fructus forsythiae, fructus gardeniae, scutellaria baicalensis, radix ophiopogonis, fructus broussonetiae, longan with core, chrysanthemum, radix paeoniae alba, radix adenophorae, semen cassiae, buddleja officinalis, equisetum hiemalis, and notopterygium root Bkg by total weight, adding 5Bkg weight of water into a tank, soaking at 60 ℃ for 2 hours, filtering to obtain filtrate I, and concentrating the filtrate I under reduced pressure to 0.5Bkg to obtain concentrated solution I for later use; adding 4Bkg weight parts of water into the residue, mixing with rhizoma Acori Graminei residue and the rest water solution, boiling for 30min, and filtering to obtain filtrate II; adding 3Bkg weight parts of water into the residue, boiling for 30min, and filtering to obtain filtrate III; mixing the filtrate II and the filtrate III, and concentrating under reduced pressure to 0.5Bkg to obtain concentrated solution II for use;
mixing the concentrated solution I and the concentrated solution II, concentrating under reduced pressure to obtain concentrated juice, cooling, mixing with the percolate, adding 95 vol% ethanol under stirring, adjusting ethanol content to 50% (that is, ethanol content is 50 vol%), standing for 12 hr, vacuum filtering, recovering ethanol from the filtrate, and concentrating under reduced pressure to 0.5 (A + B) kg to obtain concentrated solution III;
slowly pouring the concentrated solution III into 95 vol% ethanol while stirring, adjusting the alcohol content to 60%, standing for 24h, suction filtering, recovering ethanol from the filtrate, and concentrating under reduced pressure to 0.5 (A + B) kg to obtain concentrated solution IV;
slowly pouring the concentrated solution IV into 95 volume percent ethanol, stirring while adding, adjusting the alcohol content to 75%, standing for 24h, performing suction filtration, recovering ethanol from the filtrate, concentrating under reduced pressure to 0.33 (A + B) kg, volatilizing the ethanol, and cooling to obtain a concentrated solution V;
adding distilled water into the concentrated solution V to A + Bkg, stirring uniformly, decolorizing with activated carbon, filtering, evaporating the filtrate, and concentrating to 0.2 (A + B) kg to obtain concentrated solution VI;
mixing the rhizoma Acori Graminei distillate and the concentrated solution VI, adjusting pH to 7.0 with 1mol/L sodium hydroxide, standing for 48h, vacuum filtering, sterilizing the filtrate to obtain a solution II, and sealing for storage;
ckg total weight of herba asari, herba Taraxaci, cortex Phellodendri, cortex et radix Polygalae, fructus Jujubae, fructus Lycii and Poria, adding herba asari, herba Taraxaci, cortex Phellodendri, cortex et radix Polygalae, fructus Jujubae, fructus Lycii and Poria into a tank, adding 8Ckg weight of water, boiling for 1h, filtering to obtain decoction I, adding 6Ckg weight of water into the residue, boiling for 1h, filtering to obtain decoction II, mixing the decoction I and the decoction II to obtain a mixed solution, calcining Galamina with charcoal fire to red, immediately quenching into the mixed solution, soaking for 2h, taking out Galamina, calcining with charcoal fire to red, immediately quenching into the mixed solution, calcining and quenching for 7 times, grinding calamine to obtain calamine powder, adding the calamine powder into the mixed solution, boiling for 30min, filtering, concentrating the filtrate under reduced pressure to Ckg, decolorizing with activated carbon, performing suction filtration, adjusting pH to 7.0 with sodium hydroxide with the molar concentration of 1mol/L, standing for 48h, performing suction filtration, sterilizing the filtrate to obtain a prepared solution III, and sealing and storing for later use;
and mixing the solution I, the solution II and the solution III, and standing for 24h to obtain eye-protecting solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710664804.5A CN107412552B (en) | 2017-08-07 | 2017-08-07 | Eye protection liquid capable of treating myopia of children and preparation method thereof |
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| CA3182437A1 (en) * | 2020-06-11 | 2021-12-16 | Andrei V. Tkatchenko | Methods and compositions for preventing and treating myopia with berberine, a berberidaceaen alkaloid, and derivatives thereof |
| KR102599279B1 (en) * | 2023-05-19 | 2023-11-07 | 김지환 | Manufacturing method of herbal fermented eye drops |
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