CN107802670A - Chinese medicine composition of the active peptide containing ginseng with invigorating qi for relieving desertion effect and its production and use - Google Patents
Chinese medicine composition of the active peptide containing ginseng with invigorating qi for relieving desertion effect and its production and use Download PDFInfo
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- CN107802670A CN107802670A CN201711068504.7A CN201711068504A CN107802670A CN 107802670 A CN107802670 A CN 107802670A CN 201711068504 A CN201711068504 A CN 201711068504A CN 107802670 A CN107802670 A CN 107802670A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention provides a kind of Chinese medicine composition of the active peptide containing ginseng with invigorating qi for relieving desertion effect and its production and use.The composition is made up of the following raw material medicine：The parts by weight of ginseng 50 90, the parts by weight of the Radix Astragali 5 30, and the parts by weight of the bighead atractylodes rhizome 5 30.The Chinese medicine composition invigorating qi for relieving desertion effect of the present invention is notable.
Description
Technical field
The invention belongs to biological technical field, and in particular to a kind of Chinese medicine composition of active peptide containing ginseng and its preparation side
Method and purposes.
Background technology
Ginseng is also known as Asia ginseng, is the root with meat, pharmaceutically acceptable.Ginseng belongs to Araliaceae.Ginseng to physical fitness,
The effect to prolong life is not really false.Show through modern medicine study and assay, panaxoside is containing one kind in ginseng
Chemical substance, it has obvious effect to adjusting the central nervous system of people, cardiac stimulant, antifatigue, Auto-regulator metabolism etc., so
There is good therapeutic action to a variety of diseases for the treatment of nervous system cardiovascular systems, internal system and reproductive system.Ginseng
It is really not false to physical fitness, the effect to prolong life.Show through modern medicine study and assay, one kind is contained in ginseng
Be the chemical substance of panaxoside, it to adjust the central nervous system of people, cardiac stimulant, antifatigue, Auto-regulator metabolism etc. have it is bright
Aobvious effect, is controlled well so having to a variety of diseases for treating nervous system cardiovascular systems, internal system and reproductive system
Treatment acts on.
With the development of science and technology, the application of protein engineering, biologically active peptide and its egg are produced using zymolysis technique
The research and product development of white hydrolysate have become focus and main flow.
The content of the invention
An object of the present disclosure is to provide a kind of Chinese medicine composition with invigorating qi for relieving desertion effect, and it has significant mend
The de- effect of gas-solid.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition.
It is still another object of the present invention to provide a kind of Chinese medicine preparation with invigorating qi for relieving desertion effect.
A further object of the present invention is the purposes for providing the Chinese medicine composition.
The Chinese medicine composition with invigorating qi for relieving desertion effect of the present invention, is made up of the following raw material medicine：
Ginseng 50-90 parts by weight,
Radix Astragali 5-30 parts by weight, and
Bighead atractylodes rhizome 5-30 parts by weight.
Preparation in accordance with the present invention, it is preferable that the Chinese medicine composition is made up of the following raw material medicine：
Ginseng 65-85 parts by weight,
Radix Astragali 10-25 parts by weight, and
Bighead atractylodes rhizome 5-20 parts by weight.
The preparation method of Chinese medicine composition according to above-mentioned any one, it is characterised in that by the ginseng, the Radix Astragali
With the bighead atractylodes rhizome by the use of water as solvent extraction, the concentration of gained extract solution, dry, obtain the Chinese medicine composition.
Another preparation method of Chinese medicine composition according to above-mentioned any one, it is characterised in that it is included such as
Lower step：
A, ginseng is crushed, obtains ginseng pulverate；The ginseng pulverate is added into water, adjusts pH to 8~9, immersion 12~16 is small
When, separation of solid and liquid, take supernatant；
B, supernatant regulation pH to 4~6 is precipitated, separation of solid and liquid, takes solid portion；
C, the solid portion is added into water, 20~35min is heated at 75~100 DEG C, homogeneous is then carried out, is mixed
Suspension；
D, the suspension is adjusted into pH to 5~10, adds enzyme preparation and digested；The enzyme preparation is by flavor albumen
Enzyme, pepsin and neutral proteinase composition, and the weight ratio of the flavor protease, pepsin and neutral proteinase is 2
~3: 4~5: 1~2；Hydrolysis temperature is 40-65 DEG C, enzymolysis time 2-6h, obtains enzymolysis liquid；
E, after enzymolysis terminates, the Radix Astragali and the bighead atractylodes rhizome are added, extracts enzyme deactivation.The Radix Astragali and the bighead atractylodes rhizome are added into the enzymolysis liquid
In, heating and refluxing extraction, filtering, obtain mixed liquor；
F, by mixed liquor centrifugation, concentration, spray drying, the Chinese medicine composition is obtained.
According to the preparation method of described Chinese medicine composition, it is characterised in that in step B, using weak acid by the supernatant
Liquid adjusts pH to 4~6；The weak acid is selected from least one of acetic acid, lactic acid, citric acid.
According to the preparation method of described Chinese medicine composition, it is characterised in that in step E, it is described propose enzyme deactivation condition be：
Enzyme-removal temperature is 90-125 DEG C, and the enzyme deactivation time is 0.5-3h.
According to the preparation method of described Chinese medicine composition, it is characterised in that in step F, after the destroy the enzyme treatment
Enzymolysis liquid is centrifuged, and centrifugate filters through plate and frame filter press first, then through ceramic membrane filter, obtains the transmission containing active peptide
Liquid；The permeate containing active peptide is concentrated, spray drying, so as to obtain the Chinese medicine composition；The spray drying exists
Carried out at 80~105 DEG C；
According to the preparation method of described Chinese medicine composition, it is characterised in that in step F, the plate and frame filter press includes
Have a combination filtration adjuvant, the combination filtration adjuvant by activated carbon, perlite and diatomite according to weight ratio 5~6: 2~3: 1~
2 compositions.
The present invention also provides a kind of Chinese medicine preparation with invigorating qi for relieving desertion effect, it is characterised in that the Chinese medicine preparation is adopted
Chinese medicine composition is prepared in aforementioned manners.
Chinese medicine composition produced by the present invention is used to prepare the purposes of medicine or health food with invigorating qi for relieving desertion effect.
The preparation method technique of the present invention is simple, and cost is cheap, and the full constituent of ginseng is utilized, gained ginseng
Active peptide content of peptides is high, and whole good in taste, bitterness value is relatively low, and adds the Radix Astragali and the bighead atractylodes rhizome, further enhancing this Chinese medicine
The effect of composition, there is the effect of invigorating qi for relieving desertion, invigorating the spleen and stomach.
Embodiment
With reference to specific embodiment, the present invention is further illustrated, but protection scope of the present invention is not limited to
This.
<Chinese medicine composition>
The present invention provides a kind of Chinese medicine composition of the active peptide containing ginseng with invigorating qi for relieving desertion effect, it is characterised in that
The composition is made up of the following raw material medicine：
Ginseng 50-90 parts by weight,
Radix Astragali 5-30 parts by weight, and
Bighead atractylodes rhizome 5-30 parts by weight.
Preferably, according to above-mentioned Chinese medicine composition, it is characterised in that the composition is made up of the following raw material medicine：
Ginseng 65-85 parts by weight,
Radix Astragali 10-25 parts by weight, and
Bighead atractylodes rhizome 5-20 parts by weight.
For further, according to described Chinese medicine composition, it is characterised in that the composition is by the following raw material medicine system
Into：
The parts by weight of ginseng 82, the parts by weight of the Radix Astragali 12, and the parts by weight of the bighead atractylodes rhizome 6；Or
The parts by weight of ginseng 76, the parts by weight of the Radix Astragali 14, and the parts by weight of the bighead atractylodes rhizome 10；Or
The parts by weight of ginseng 80, the parts by weight of the Radix Astragali 11, and the parts by weight of the bighead atractylodes rhizome 9.
In the present invention, the effect of ginseng, the Radix Astragali and the bighead atractylodes rhizome are respectively provided with very good invigorating qi for relieving desertion.Ginseng active peptide is compared
It is more favorable for digesting and assimilating in ginseng, and effect is more obvious, can equally use with the bighead atractylodes rhizome, the Radix Astragali.In this composition, we will
Ginseng enzymolysis is ginseng active peptide, is small-molecule substance and polypeptide by large protein enzymolysis, beneficial to the intestinal absorption of our human bodies, and
The effect of having played peptide.
Matched according to the composition of the present invention, ginseng active peptide gives full play to its effect, the Radix Astragali and the bighead atractylodes rhizome are made as main material
Added for auxiliary, further play its effect, and the mouthfeel and bitter taste of composition can be changed.
The Radix Astragali, also known as astragali or northern alpine yarrow, also make astragalus or one of yellow alpine yarrow, conventional Chinese medicine.With Radix Astragali invigorating qi for strengthening superficies effect phase
The pharmacological action of pass is enhancing body's immunity, enhancing hematopoiesis function.Improve metabolism, enhancing gonad function, resisting stress,
Anti-aging etc. acts on.The Radix Astragali also has the effects such as cardiac stimulant, regulation blood pressure, antiviral property myocarditis, liver protection, antiulcer.The Radix Astragali
Polysaccharide and astragaloside are its principle active components.Normal mouse gavage Astragalus membranaceus can increase hepatic glycogen.The Radix Astragali is to four
Chlorination carbon, which causes total serum protein caused by liver damage and albumin to reduce, rise effect, and caused by preventing carbon tetrachloride
Hepatic glycogen reduce.The Radix Astragali can increase 3H- leucines incorporation hepatic protein and promote its renewal.Chronic hepatitis B patients are present
Cellular Immune Disturbances, recover normal immunological function, improve the ability removed virus or suppress virus diffusion.The Radix Astragali can strengthen
Rat and the muscular strength of mouse.Rat oral gavage Astragalus membranaceus 6 days or 14 days, can strengthen the fatigue proof effect of rats'swimming, and make
Suppressor cells rat plasma Determination of cortisol substantially increases, more than blank stress group and the level of Normal group.The Radix Astragali can make
The increase of Suppressor cells adult rat adrenal tissue weight, adrenal cortex thicken, and the increase of zona fasciculata cell volume, endochylema enrich.Show Huang
Stilbene enhancing rat anti-stress ability is realized by strengthening adrenal cortex function.The bighead atractylodes rhizome：For the feverfew bighead atractylodes rhizome, with root
Stem is used as medicine.Drying damp and strengthening spleen, spleen eating less, indigestion, chronic diarrhea, oedema, hidroschesis are antiabortive.Antibacterial action：Infusion is trying
There is inhibitory action to acrothesium floccosum, star nocardia in pipe.Decoction also has inhibitory action to meningococcus.Nearly report
Bighead atractylodes rhizome decoction and Sijunzi Tang are to typhoid bacillus, paratyphoid bacillus A, shigella flexneri, Escherichia coli, Pseudomonas aeruginosa etc.
There is different degrees of bacteriostasis, and without bactericidal action.The bighead atractylodes rhizome decoction 1g/kg, 0.2ml/, which are only subcutaneously injected, can promote mouse
The growth of marrow hemopoietic progenitor cell of red blood cell line.Decline for the white blood cell caused by chemotherapy or radiotherapy, having makes its rise
Effect.Rabbit gavage decoction or medicinal extract, blood glucose are in a slight decrease.Rat oral gavage decoction has the assimilation of glucose in acceleration bodies thus
Reduce blood glucose.Mouse, which takes decoction orally, protection liver, prevents liver glycogen reduction caused by carbon tetrachloride from acting on.
In addition to objects, features and advantages described above, the present invention also has other objects, features and advantages.
The present invention is further detailed explanation below.
<Preparation method>
According to the first embodiment of the present invention, the preparation method of the Chinese medicine composition includes：By the ginseng, Huang
Stilbene and the bighead atractylodes rhizome concentration of gained extract solution, are dried by the use of water as solvent extraction, obtain the Chinese medicine composition.
According to the first embodiment of the present invention, the preparation method of the Chinese medicine composition comprises the following steps：
A, ginseng is crushed, obtains ginseng pulverate；The ginseng pulverate is added into water, adjusts pH to 8~9, immersion 12~16 is small
When, separation of solid and liquid, take supernatant；
B, supernatant regulation pH to 4~6 is precipitated, separation of solid and liquid, takes solid portion；
C, the solid portion is added into water, 20~35min is heated at 75~100 DEG C, homogeneous is then carried out, is mixed
Suspension；
D, the suspension is adjusted into pH to 5~10, adds enzyme preparation and digested；The enzyme preparation is by flavor albumen
Enzyme, pepsin and neutral proteinase composition, and the weight ratio of the flavor protease, pepsin and neutral proteinase is 2
~3: 4~5: 1~2；Hydrolysis temperature is 40-65 DEG C, enzymolysis time 2-6h, obtains enzymolysis liquid；
E, after enzymolysis terminates, the Radix Astragali and the bighead atractylodes rhizome are added, extracts enzyme deactivation.The Radix Astragali and the bighead atractylodes rhizome are added into the enzymolysis liquid
In, heating and refluxing extraction, filtering, obtain mixed liquor；
F, by mixed liquor centrifugation, concentration, spray drying, the Chinese medicine composition is obtained.
According to the preparation method of described Chinese medicine composition, it is characterised in that in step D, it is described propose enzyme deactivation condition be：
Enzyme-removal temperature is 90-125 DEG C, and the enzyme deactivation time is 0.5-3h.
Preparation in accordance with the present invention, in step A, the particle diameter of the ginseng pulverate is 2~75 μm.The ginseng pulverate can be with
By the way that dry ginseng is carried out into ultramicro grinding, then sieving obtains, such as crosses 200~600 mesh sieves.Using the people of the particle diameter of the present invention
Join powder, enzymatic hydrolyzation can be effectively improved in the enzymolysis step in later stage, make full use of the protein ingredient in ginseng.The immersion is excellent
Elect as and soaked under agitation, so that the composition in ginseng pulverate is fully dissolved out.In step A, amount of water is ginseng pulverate's weight
3~20 times, preferably 5~10 times.Preferably, after the completion of process is soaked, mechanical agitation is carried out, so that liquid is uniform,
It is easy to centrifuge.
Preparation in accordance with the present invention, in step A, the solid-liquid separating method can be filtering, centrifugation etc., and preferably
To centrifuge.In step A, immersion process can be heated or carried out at normal temperatures, and preferably be carried out at normal temperatures.Generally, alkali
Need to be heated in liquid immersion process；And inventor has found, immersion can be abundant by the composition in ginseng pulverate at normal temperatures
Dissolution, so as to avoid carrying out heating caused additional energy, and more convenient operation.
Preparation in accordance with the present invention, in step B, make protein denaturation using heating means.In described fire-bar
It can realize that the protein component in ginseng is denatured completely under part, and be advantageous to fully be digested in subsequent step, simultaneously
And avoid pollution of the chemical reagent to product.Homogeneous is carried out after heat distortion, further increases enzymolysis efficiency.
Preparation in accordance with the present invention, in step C, the suspension is adjusted to pH5~10, preferably pH7~9,
More preferably pH7~8.In the present invention, pH is adjusted to above-mentioned alkalescent, be more beneficial for the present invention enzyme preparation digested.
In the present invention, enzyme preparation is 2~3: 4~5: 1~2 groups according to weight ratio by flavor protease, pepsin and neutral proteinase
Into.According to the preferred embodiment of the present invention, the weight ratio of flavor protease, pepsin and neutral proteinase is 2.3~2.8
: 4.3~4.8: 1.2~1.7.According to one preferred embodiment of the invention, flavor protease, pepsin and neutral protein
The weight ratio of enzyme is 2.5: 4.5: 1.4.The enzymolysis process of the present invention disposably adds above-mentioned enzyme preparation, and under the conditions of above-mentioned pH
Digested, more preferably hydrolysis result can be obtained.Enzymolysis efficiency of the enzyme preparation of the present invention for the protein component in ginseng
It is high, hence it is evident that it is alone higher than every kind of enzyme, and it is higher than existing ginseng active peptide enzyme.When flavor protease, pepsin and neutrality
When the weight ratio of protease is 2.5: 4.5: 1.4, enzymolysis efficiency highest.Preparation in accordance with the present invention, the enzyme preparation
Addition can be the 0.2~2wt%, preferably 0.3~1.5wt%, more preferably 0.4 of solid content weight in the suspension
~1.2wt%.In the present invention, hydrolysis temperature is 40~65 DEG C, and enzymolysis time is 1.5~8h；Preferably, hydrolysis temperature be 45~
60 DEG C, enzymolysis time is 2~6h.The addition of above-mentioned enzyme preparation, enzymolysis time and at a temperature of, ginseng protein can be realized effectively
Enzymolysis.
Preparation in accordance with the present invention, in step D, the Radix Astragali and the bighead atractylodes rhizome can add the enzymolysis in powder form
In liquid, so as to improve recovery rate.The heating and refluxing extraction time is 0.5~3 hour, preferably 1~2 hour.The filtering can adopt
With customary filtration methods, so as to filter off the dregs of a decoction, mixed liquor is obtained.
Preparation in accordance with the present invention, in step E, the mixed liquor is centrifuged, centrifugate is first through sheet frame pressure
Filter filters, then through ceramic membrane filter, filtrate concentration, spray drying, so as to obtain the composition of the refined active peptide containing ginseng.
Preferably, the spray-drying operation is in 80~105 DEG C of progress, so as to effectively keep the activity of ginseng active peptide.
In the present invention, containing combination filtration adjuvant in the plate and frame filter press, the combination filtration adjuvant is by activated carbon, treasure
Zhu Yan and diatomite composition, and activated carbon, perlite and diatomaceous weight ratio 5~6: 2~3: 1~2.According to the one of the present invention
Individual preferred embodiment, it is described to combine activated carbon, perlite and diatomaceous weight ratio 5.5: 2.5: 1.5 in filtration adjuvant.
According to another preferred embodiment of the present invention, activated carbon, perlite and diatomaceous heavy in the combination filtration adjuvant
Measure ratio 5.7: 2.8: 1.3.Inventor has found that ginseng active peptide prepared by existing method carries peculiar smell, and has bitter taste, mouthfeel
Difference；A variety of filtration adjuvants are alone to be difficult to simultaneously remove the two.The filtration adjuvant of the present invention can effectively remove ginseng in itself
The peculiar smell and bitter taste carried, simplifies technological process.In the present invention, the aperture of the ceramic membrane can be 20~500nm, more excellent
Elect 20~300mm as.Using such ceramic membrane aperture, further refining for enzymolysis liquid can be realized.Preferably, the spraying
Drying process is in 80~105 DEG C of progress, so as to effectively keep the activity of ginseng active peptide.
It is pointed out that generally the spray-drying operation of peptide is in 120~140 DEG C of progress, it is considered that such drying
Temperature is little for the activity influence of peptide.However, it is found by the inventors that the temperature of existing spray drying significantly affects the work of peptide
Property.And in the present invention, it is preferable that the spray-drying operation is in 80~105 DEG C of progress, so as to effectively keep ginseng active peptide
Activity.
<Chinese medicine preparation>
The Chinese medicine preparation of the present invention includes above-mentioned Chinese medicine composition, can also include pharmaceutically acceptable auxiliary material.Institute
Stating the administering mode of Chinese medicine preparation can select orally.The form of Chinese drug can be selected from any in pulvis, tablet, pill
Kind.There is the Chinese medicine preparation significant invigorating qi for relieving desertion to act on, and convenient to take.
<Purposes>
The Chinese medicine composition of the present invention can be used for preparing medicine or health food with invigorating qi for relieving desertion effect.
Embodiments of the invention are described in detail below, but protection scope of the present invention is not limited.
Embodiment 1
The parts by weight of ginseng 80, the parts by weight of the Radix Astragali 10 and the parts by weight of the bighead atractylodes rhizome 10 are mixed, add water to be heated to reflux carrying as solvent
Taking, extraction time is 3 times, and each amount of water is 5 times of ginseng, the Radix Astragali and bighead atractylodes rhizome gross weight, and each extraction time is 2 hours,
Extract solution filters, and merges, and concentrates, and dries, obtains Chinese medicine composition A.
Embodiment 2
A, ginseng is subjected to ultramicro grinding, crosses 400 mesh sieves, obtain the parts by weight of ginseng pulverate 82；Ginseng pulverate is added into ginseng pulverate
The water of 5 times of amounts of weight, mixing, adjusted with sodium hydroxide solution to pH 8, soak 16h；Mechanical agitation, centrifugation, takes supernatant；
B, by supernatant, 25min is heated at 95 DEG C, homogeneous is then carried out, obtains suspension；
C, the suspension is adjusted into pH to 8, adds enzyme preparation and digested, obtain enzymolysis liquid；The enzyme preparation is by flavor
Protease, pepsin and neutral proteinase are according to 2.5: 4.5: 1.4 compositions；The dosage of enzyme preparation is solid content weight in suspension
The 0.5wt% of amount；Hydrolysis temperature is 50 DEG C, enzymolysis time 2h；
D, after enzymolysis terminates, the parts by weight of the Radix Astragali 12 and the parts by weight of the bighead atractylodes rhizome 6 is added in the enzymolysis liquid, are heated to reflux carrying
Take, extraction time 2h, filter, obtain mixed liquor；
E, the mixed liquor is centrifuged, centrifugate is filtered through plate and frame filter press, and filtration adjuvant, mistake are contained in plate and frame filter press
Filter auxiliary agent is made up of activated carbon, perlite and diatomite according to weight ratio 5.5: 2.5: 1.5；Via hole diameter is 400nm ceramics again
Membrane filtration, filtrate concentration, in 85 DEG C of spray drying in middle low-temperature spray drying tower, obtain the Chinese traditional medicine composition of the active peptide containing ginseng
Thing.
Embodiment 3
By the parts by weight of Chinese medicine composition 82, the parts by weight of lactose 16, the parts by weight of microcrystalline cellulose 1, tristearin made from embodiment 1
The sour parts by weight of magnesium 1, by sieving, weighing, mixing, pelletizing, tabletting obtains tablet.
Embodiment 4
By the parts by weight of Chinese medicine composition 82, the parts by weight of PURE WHEY 8, the parts by weight of konjaku flour 5, wheat made from embodiment 1
The parts by weight of bud dextrin 2, the parts by weight of crystal diabetin 2, the parts by weight of inulin 1, by sieving, weighing, mixing, being packaged to be pulvis.
Comparative example 1
Except the acetum of step B in embodiment 2 is replaced with into hydrochloric acid solution, other steps are same as Example 2.
Comparative example 2
Activated carbon except the filtration adjuvant of step E in embodiment 2 to be replaced with to equivalent weight, other steps and embodiment
2 is identical.
Comparative example 3
Perlite except the filtration adjuvant of step E in embodiment 2 to be replaced with to equivalent weight, other steps and embodiment
2 is identical.
Comparative example 4
Diatomite except the filtration adjuvant of step E in embodiment 2 to be replaced with to equivalent weight, other steps and embodiment
2 is identical.
Comparative example 5
Except the spray drying temperature of step E in embodiment 2 is arranged into 135 DEG C, other steps are same as Example 2.
The taste of composition in embodiment 1~2 and comparative example 1~5 is determined, the results are shown in Table 1.
Bitter taste estimate method is：Take 1g ginsengs active peptide to add in 10ml warm water to stir, extension rate is calculated as hardship
Taste value, calculate the average bitterness value of 20 people.
Fishy smell evaluation method is：Evaluation method is：0- is without fishy smell；1- slightly has fishy smell；2- fishy smell is weaker；3- has fishy smell；4-
Fishy smell is general；5- fishy smell is laid particular stress on；6- fishy smell is heavier；The average fishy smell value of the 7- fishy smell very people of re-computation 20.
Table 1
The present invention is not limited to above-mentioned embodiment, in the case of without departing substantially from the substantive content of the present invention, this area skill
Any deformation, improvement, the replacement that art personnel are contemplated that each fall within the scope of the present invention.
Claims (10)
1. it is a kind of with invigorating qi for relieving desertion effect the active peptide containing ginseng Chinese medicine composition, it is characterised in that the composition by
The following raw material medicine is made：
Ginseng 50-90 parts by weight,
Radix Astragali 5-30 parts by weight, and
Bighead atractylodes rhizome 5-30 parts by weight.
2. Chinese medicine composition according to claim 1, it is characterised in that the composition is made up of the following raw material medicine：
Ginseng 65-85 parts by weight,
Radix Astragali 10-25 parts by weight, and
Bighead atractylodes rhizome 5-20 parts by weight.
3. Chinese medicine composition according to claim 1, it is characterised in that the composition is made up of the following raw material medicine：
The parts by weight of ginseng 82, the parts by weight of the Radix Astragali 12, and the parts by weight of the bighead atractylodes rhizome 6；Or
The parts by weight of ginseng 76, the parts by weight of the Radix Astragali 14, and the parts by weight of the bighead atractylodes rhizome 10；Or
The parts by weight of ginseng 80, the parts by weight of the Radix Astragali 11, and the parts by weight of the bighead atractylodes rhizome 9.
4. the preparation method of the Chinese medicine composition according to claim any one of 1-3, it is characterised in that by the ginseng,
The Radix Astragali and the bighead atractylodes rhizome powder concentration of gained extract solution, are dried by the use of water as solvent extraction, obtain the Chinese medicine composition.
5. the preparation method of the Chinese medicine composition according to claim any one of 1-3, it is characterised in that it includes following step
Suddenly：
A, ginseng is crushed, obtains ginseng pulverate；The ginseng pulverate is added into water, adjusts pH to 8~9, is soaked 12~16 hours, Gu
Liquid separates, and takes supernatant；
B, supernatant regulation pH to 4~6 is precipitated, separation of solid and liquid, takes solid portion；
C, the solid portion is added into water, 20~35min is heated at 75~100 DEG C, homogeneous is then carried out, is suspended
Liquid；
D, the suspension is adjusted into pH to 5~10, adds enzyme preparation and digested；The enzyme preparation is by flavor protease, stomach
Protease and neutral proteinase composition, and the weight ratio of the flavor protease, pepsin and neutral proteinase is 2~3: 4
~5: 1~2；Hydrolysis temperature is 40-65 DEG C, enzymolysis time 2-6h, obtains enzymolysis liquid；
E, after enzymolysis terminates, the Radix Astragali and the bighead atractylodes rhizome are added, extracts enzyme deactivation.The Radix Astragali and the bighead atractylodes rhizome are added in the enzymolysis liquid,
Heating and refluxing extraction, filtering, obtains mixed liquor；
F, by mixed liquor centrifugation, concentration, spray drying, the Chinese medicine composition is obtained.
6. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that in step B, using weak acid by institute
State supernatant regulation pH to 4~6；The weak acid is selected from least one of acetic acid, lactic acid, citric acid.
7. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that in step E, the extraction enzyme deactivation
Condition be：Enzyme-removal temperature is 90-125 DEG C, and the enzyme deactivation time is 0.5-3h.
8. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that in step E, at the enzyme deactivation
Enzymolysis liquid after reason is centrifuged, and centrifugate filters through plate and frame filter press first, then through ceramic membrane filter, is obtained containing active peptide
Permeate；The permeate containing active peptide is concentrated, spray drying, so as to obtain the Chinese medicine composition；The spraying is dry
It is dry to be carried out at 80~105 DEG C；Containing combination filtration adjuvant in the plate and frame filter press, the combination filtration adjuvant is by activity
Charcoal, perlite and diatomite form according to weight ratio 5~6: 2~3: 1~2.
9. a kind of Chinese medicine preparation with invigorating qi for relieving desertion effect, it is characterised in that the Chinese medicine preparation includes claim 1-3 and appointed
Chinese medicine composition made from Chinese medicine composition described in one or the preparation method according to claim any one of 4-8.
10. the Chinese medicine composition according to claim any one of 1-3 or the preparation according to claim any one of 4-8
Chinese medicine composition made from method is used to prepare the purposes of medicine or health food with invigorating qi for relieving desertion effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Cited By (1)
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| CN118235863A (en) * | 2024-04-30 | 2024-06-25 | 山东太爱肽生物科技股份有限公司 | Special diet with anti-aging effect and preparation method thereof |
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| CN104789629A (en) * | 2015-04-30 | 2015-07-22 | 中国食品发酵工业研究院 | Chickpea oligopeptide and preparation method thereof |
| CN105669830A (en) * | 2015-12-15 | 2016-06-15 | 北京天肽生物科技有限公司 | Composite oligopeptide powder |
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