CN108888721A - A kind of liquid medicine and preparation method thereof with swelling diuretic effect - Google Patents
A kind of liquid medicine and preparation method thereof with swelling diuretic effect Download PDFInfo
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Abstract
The invention belongs to food wine brewing fields, disclose a kind of liquid medicine and preparation method thereof with swelling diuretic effect, and the liquid medicine is composed of the following components：3-5 parts of Indian Flagellaria glycosides displayed,2-4 parts of root of fangji total alkaloid,15-20 parts of rhizome of chuanxiong,15-20 parts of Radix Astragali,8-12 parts of aster,10-15 parts of the root bark of white mulberry,10-12 parts of semen plantaginis,8-12 parts of Rhizoma Atractylodis Macrocephalae,8-10 parts of caulis akebiae,10-15 parts of kuh-seng,10-15 parts of corn stigma,10-12 parts of rde bean,8-12 parts of Chinese Ixeris,60% 600-700 parts of white wine,250-300 parts of sucrose,The present invention passes through Indian Flagellaria glycosides displayed,Root of fangji total alkaloid and rhizome of chuanxiong,Radix Astragali,Aster,The root bark of white mulberry,Semen plantaginis,Rhizoma Atractylodis Macrocephalae,Caulis akebiae,Kuh-seng,Corn stigma,Rde bean,There is Chinese Ixeris etc. the Chinese medicine of swelling diuretic effect to be used in compounding,Being prepared into can be by adjusting brain centres nerve,Urine is promoted to generate and be discharged,And on renal function without influence,And the oedema that can effectively subside,Liquid medicine with good swelling diuretic effect.
Description
Technical field
The present invention relates to Traditional Chinese medicinal liquor technical fields, and in particular to a kind of liquid medicine and its preparation with swelling diuretic effect
Method.
Background technique
The taste of Chinese medicine is mostly not only bitter but also tasty, and then taste is pure and sweet for wine, and entrance makes us aftertaste, by Chinese medicine in conjunction with wine,
Health care function can be reached when tasting vinosity.But the good price of health liquor effect in the market is general to make
Make process complexity, industrial requirements are high, expensive starting materials, therefore the price of wine is caused to increase, and cheap effect is poor, have comprehensive
Health-care effect, but act on it is limited, can not be solved for a certain individual problem.For urine difficulty, benefit is mostly used at present
Agent frusemide, Hydrochioro etc. are urinated, but is easy to appear side effect using Western medicine, such as causes the disorder of whole body electrolyte, blood volume
It reduces, the symptoms such as metabolic acid or alkali poisoning, and diuretic effect is general, is only capable of respite illness, and cannot fundamentally solve
Certainly problem.Chinese patent《A kind of drymaria grass diuresis defaecation wine and preparation method thereof》(patent publication No.：CN105079534A),
Patent《A kind of stachyurus pith reducing fever and causing diuresis wine and preparation method thereof》(patent publication No.：CN105087326A) disclosing has benefit
Urinate defaecation, heat-clearing toxin-expelling functions liquid medicine, but do not have swelling and pain relieving act on, therefore, research and develop it is a can swelling diuretic, heat-clearing
The problem of detoxifying, while there is the liquid medicine of analgesic effect to be current urgent need to resolve.
Summary of the invention
To solve the above-mentioned problems, the present invention provides a kind of liquid medicine and preparation method thereof with swelling diuretic effect,
Pass through Indian Flagellaria glycosides displayed, root of fangji total alkaloid and rhizome of chuanxiong, Radix Astragali, aster, the root bark of white mulberry, semen plantaginis, Rhizoma Atractylodis Macrocephalae, caulis akebiae, kuh-seng, jade
The Chinese medicines with swelling diuretic effect such as rice palpus, rde bean, Chinese Ixeris are used in compounding, and being prepared into can be by adjusting brain centres mind
Promoted urine to generate and be discharged, and on renal function without influence, and the oedema that can effectively subside, there is good swelling diuretic to make
Liquid medicine.
The present invention can be achieved through the following technical solutions：
A kind of liquid medicine with swelling diuretic effect, it is composed of the following components：3-5 parts of Indian Flagellaria glycosides displayed, the root of fangji are always given birth to
2-4 parts of alkaloids, 15-20 parts of rhizome of chuanxiong, 15-20 parts of Radix Astragali, 8-12 parts of aster, 10-15 parts of the root bark of white mulberry, 10-12 parts of semen plantaginis, Rhizoma Atractylodis Macrocephalae
8-12 parts, 8-10 parts of caulis akebiae, 10-15 parts of kuh-seng, 10-15 parts of corn stigma, 10-12 parts of rde bean, 8-12 parts of Chinese Ixeris, 60% white wine
600-700 parts, 250-300 parts of sucrose.
Preferably, a kind of liquid medicine with swelling diuretic effect is composed of the following components：Indian Flagellaria glycosides displayed 3.5-
4.5 parts, 2.5-3.5 parts of root of fangji total alkaloid, 16-19 parts of rhizome of chuanxiong, 16-19 parts of Radix Astragali, 9-11 parts of aster, 11-14 parts of the root bark of white mulberry,
10.5-11.5 parts of semen plantaginis, 9-11 parts of Rhizoma Atractylodis Macrocephalae, 8.5-9.5 parts of caulis akebiae, 11-14 parts of kuh-seng, 11-14 parts of corn stigma, rde bean
10.5-11.5 parts, 9-11 parts of Chinese Ixeris, 625-675 parts of 60% white wine, 260-290 parts of sucrose.
Preferably, a kind of liquid medicine with swelling diuretic effect is composed of the following components：4 parts of Indian Flagellaria glycosides displayed,
3 parts of root of fangji total alkaloid, 17 parts of rhizome of chuanxiong, 18 parts of Radix Astragali, 10 parts of aster, 12 parts of the root bark of white mulberry, 11 parts of semen plantaginis, 10 parts of Rhizoma Atractylodis Macrocephalae, wood
Lead to 9 parts, 13 parts of kuh-seng, 12 parts of corn stigma, 11 parts of rde bean, 10 parts of Chinese Ixeris, 650 parts of 60% white wine, 275 parts of sucrose.
Preferably, the preparation method of the Indian Flagellaria glycosides displayed is：
A. it takes Indian Flagellaria to be ground into the particle that granularity is 0.5-1.5cm, is 1 by solid-liquid ratio:8 are added 50% ethanol solution
In, after impregnating 3-5h at 70 DEG C, refluxing extraction 2h is extracted twice, and filtering, combined extract is recovered under reduced pressure ethyl alcohol, obtains dense
Contracting liquid；
B. it takes concentrate that the flocculant of concentrate 2% is added, stirs evenly, staticly settle, centrifuging and taking supernatant is used
The sodium hydrate aqueous solution of 0.5mol/L adjusts supernatant pH to 9, generates flocculent deposit, and centrifugal filtration takes filtrate to use 0.5mol/
The aqueous hydrochloric acid solution of L adjust filtrate pH to；
C. take D101 resin and polyamide by 1:1 mixes dress column, and the extracting solution of above-mentioned purifying is pressed 3g/100ml tree
The upper column quantity upper prop of rouge, with the distillation water elution of 4 times of column volumes, then with 20% ethanol elution of 2 times of volumes, then with 70% second
Alcohol desorption takes stripping liquid concentrated, dry, obtains Indian Flagellaria glycosides displayed.
Preferably, the preparation method of the root of fangji total alkaloid is：It takes Fourstamen Stephania Root to be put into beaker, is 1 by solid-liquid ratio:
13 are added 55% ethanol solution, shake up, and stand 10min, are put into micro-wave oven and heat, and set power as 480W, radiate every time
1min is spaced re-radiation 1min after 1min, and such spaced radiation to 3.5min filters, and repeats to extract once by similarity condition, close
And filtrate, vacuum distillation to no alcohol taste twice, 1% hydrochloric acid of 10ml is then added, is filtered after standing 48h with filter paper and removes precipitating,
Filtrate pH=9 is adjusted with concentrated ammonia liquor again, is filtered after placing 48h, after taking precipitating dry, is dissolved by heating with 1.5ml acetone, in solution
Middle drop 1-2 drop distilled water is micro- turbid to solution, places and is volatilized to solution to get root of fangji total alkaloid is arrived.
A kind of preparation method of the liquid medicine with swelling diuretic effect, includes the following steps：
(1) rhizome of chuanxiong, Radix Astragali, aster, the root bark of white mulberry, semen plantaginis, Rhizoma Atractylodis Macrocephalae, caulis akebiae, kuh-seng, corn stigma, rde bean and Chinese Ixeris are taken
Mixing, pulverizing to partial size is 10-25 μm, and Indian Flagellaria glycosides displayed and root of fangji total alkaloid is added, and after mixing evenly, is added
60% white wine heating and refluxing extraction 2h, filtering, obtains filtrate；
(2) it takes filtrate that sucrose is added, after mixing evenly, adjusts pH to 4.5-4.8, the yeast of activation is accessed, at 25 DEG C
Heat-preservation fermentation 8-10 days, filtering obtained fermentation liquid；
(3) after moving into fermentation liquid in fermentation tank, latter ferment 15-20 days at 12-15 DEG C, clarified solution is taken to move into ageing container
In, it is stored 2 months or more at 6-8 DEG C and carries out ageing；
(4) after ageing, tannin is added, stirs evenly, stand 6-8 days, upper layer is taken to clarify wine liquid after precipitating completely
It is filtered the liquid medicine that there is swelling diuretic effect to get the present invention.
Preferably, the inoculum concentration of the yeast activated in the step (2) is 8-10%.
Preferably, the dosage of tannin used in the step (4) is the 0.06-0.07 of wine liquid amount.
Each main composition mechanism of action of the present invention is as follows：
Rhizome of chuanxiong is warm-natured, acrid flavour, has the functions such as promoting blood circulation, promoting the circulation of qi, menstruation regulating, wind-dispelling, dissolving stasis, analgesic, contained rhizome of chuanxiong piperazine has
Significant inducing diuresis to remove edema effect；Radix Astragali is leguminous perennial herb, sweet in flavor, slightly warm in nature, there is tonifying Qi and lifting yang, benefit to defend solid
The efficacy of table, inducing diuresis for removing edema, the pathological change of the substantially reduced glomerular mesangium of energy have diuresis to protect kidney
Detumescence effect；Aster bitter, pungent, sweet, slightly warm in nature has the effect of moistening lung to lower qi, cough-relieving apophlegmatic, can pass through and adjust braingut petide
Secretion, thus play tonneau effect；Caulis akebiae has the effect of newborn under inducing diuresis for treating strangurtia, relieving restlessness and restlessness, promoting menstruation, and wherein caulis akebiae water mentions
Object has stronger diuresis.
The root bark of white mulberry is the dry root skin of Moraceae Mulberry plant mulberry, has removing heat from lung and relieving asthma, inducing diuresis for removing edema and other effects, and is had aobvious
The diuresis of work, and renal function is not damaged significantly；Semen plantaginis is the dry mature seed of plantago plant Chinese herbaceous peony,
There is the effect for the treatment of stranguria reducing fever and causing diuresis, excreting dampness, improving eyesight eliminating the phlegm, in addition to diuresis, moreover it is possible to increase urea, chloride and uric acid
Excretion；Rhizoma Atractylodis Macrocephalae has effects that invigorate the spleen and benefit qi, eliminate dampness and have diuretic effect, strengthening exterior and reducing sweat, has obvious and lasting diuresis, not only increases
Add the excretion of water, also promotes the discharge of electrolyte especially sodium；Chinese Ixeris is the herb of compositae plant sonchus oleraceus, has heat-clearing cool
Blood, receives all products in tripe abdomen, diuresis and other effects at removing toxicity for detumescence.
Kuh-seng bitter cold in nature has the function of heat-clearing and damp-drying drug, desinsection, diuresis, containing alkaloids, flavonoids isoreactivity object
Matter, matrine contained therein are the main components of diuresis effect, have apparent diuresis；Corn stigma is gramineous crop jade
The drying style and column cap of rice have inducing diuresis for removing edema, antihypertensive effect, contain phytosterol, polysaccharide, alkaloid, flavones, hidden Huang
The Multiple components such as element can increase the discharge rate of chloride, and effect is lasting, have apparent diuresis；Rde bean is main
Containing compounds such as Pentacyclic triterpene saponins, flavonoids, tannins, there is anti-oxidant, enhancing to be immunized, antibacterial, estrogen-like action
And the pharmacological actions such as diuresis.
Indian Flagellaria is Flagellariaceae Indian Flagellaria platymiscium, warm-natured, flat, acrid flavour, swollen with alleviating water retention, convergence wound function
Effect, main active is glycosides displayed, to Pseudomonas aeruginosa, Escherichia coli, typhoid bacillus, shigella dysenteriae, Staphylococcus aureus
Bacterium etc. has different degrees of bacteriostasis, has the pharmacological effects such as antiviral, antibacterial anti-inflammatory, and have no toxic side effect；The root of fangji is
The dry root of Menispermaceae stephania plant Fourstamen Stephania Root, it is bitter in taste, cold, return bladder, lung channel, main component has alkaloid, double
Flavonoids, volatile oil, carbohydrate etc., wherein alkaloid be Chinese medicine root of fangji inducing diuresis for removing edema, removing damp-heat, dispelling wind and eliminating pain chief active
Ingredient, and there are the pharmacological actions such as antibacterial anti-inflammatory, antiallergy, anti-hepatic fibrosis.
The present invention has following beneficial effect：
(1) present invention is using rhizome of chuanxiong, Radix Astragali, aster, the root bark of white mulberry, semen plantaginis, Rhizoma Atractylodis Macrocephalae, caulis akebiae, kuh-seng, corn stigma, red small
The warming yang for diuresis such as beans and Chinese Ixeris, promoting diuresis with drugs of tasteless flavour, invigorating spleen for diuresis Chinese medicine prepare liquid medicine, being capable of dampness removing and treating stranguria, detoxicating and resolving a mass, benefit
Water detumescence, improves kidney function, and urine is promoted to generate and be discharged, and increases the excretion of the electrolyte such as urine sodium, potassium, chlorine, inhibits kidney small
Reabsorption of the pipe to water, electrolyte, to reach inducing diuresis to remove edema effect；
(2) it is effectively abundant to extract it from Indian Flagellaria by the present invention, and by purifying resin, improves active constituent content, and
It is used in compounding with by the root of fangji total alkaloid of microwave radiation exaraction, enhancing inducing diuresis for removing edema, removing damp-heat and other effects, and the present invention
Extracting method used is compared with the traditional method, and not only recovery rate is high, and easy to operate, energy saving, is more fully extracted effective
Ingredient；
(3) liquid medicine of the invention has apparent inducing diuresis to remove edema effect, and urine can be promoted to generate and be discharged, increase urine
The excretion of the electrolyte such as sodium, potassium, chlorine, and on renal function without influence, and liquid medicine preparation process of the invention is simple, it is at low cost
It is honest and clean, it conveniently drinks, long shelf-life, there is very good inducing diuresis to remove edema effect.
Specific embodiment
In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, tie below
Specific embodiment is closed, the present invention is further explained.
A kind of embodiment 1-5 formula of liquid medicine with swelling diuretic effect of the present invention, as shown in table 1：
Table 1
The preparation method of above-mentioned Indian Flagellaria glycosides displayed is：
A. it takes Indian Flagellaria to be ground into the particle that granularity is 0.5-1.5cm, is 1 by solid-liquid ratio:8 are added 50% ethanol solution
In, after impregnating 3-5h at 70 DEG C, refluxing extraction 2h is extracted twice, and filtering, combined extract is recovered under reduced pressure ethyl alcohol, obtains dense
Contracting liquid；
B. it takes concentrate that the flocculant of concentrate 2% is added, stirs evenly, staticly settle, centrifuging and taking supernatant is used
The sodium hydrate aqueous solution of 0.5mol/L adjusts supernatant pH to 9, generates flocculent deposit, and centrifugal filtration takes filtrate to use 0.5mol/
The aqueous hydrochloric acid solution of L adjust filtrate pH to；
C. take D101 resin and polyamide by 1:1 mixes dress column, and the extracting solution of above-mentioned purifying is pressed 3g/100ml tree
The upper column quantity upper prop of rouge, with the distillation water elution of 4 times of column volumes, then with 20% ethanol elution of 2 times of volumes, then with 70% second
Alcohol desorption takes stripping liquid concentrated, dry, obtains Indian Flagellaria glycosides displayed.
The preparation method of above-mentioned root of fangji total alkaloid is：It takes Fourstamen Stephania Root to be put into beaker, is 1 by solid-liquid ratio:13 are added
55% ethanol solution, shakes up, and stands 10min, is put into micro-wave oven and heats, set power as 480W, radiate 1min every time, is spaced
Re-radiation 1min after 1min, such spaced radiation to 3.5min filter, and repeat to extract once by similarity condition, merging is filtered twice
Then 1% hydrochloric acid of 10ml is added to no alcohol taste in liquid, vacuum distillation, precipitated after standing 48h with filter paper filtering removal, then with dense ammonia
Water adjusts filtrate pH=9, filters after placing 48h, after taking precipitating dry, is dissolved by heating with 1.5ml acetone, drips 1-2 in the solution
It is micro- turbid to solution to drip distilled water, places and is volatilized to solution to get root of fangji total alkaloid is arrived.
A kind of preparation method of above-mentioned liquid medicine with swelling diuretic effect, includes the following steps：
(1) rhizome of chuanxiong, Radix Astragali, aster, the root bark of white mulberry, semen plantaginis, Rhizoma Atractylodis Macrocephalae, caulis akebiae, kuh-seng, corn stigma, rde bean and Chinese Ixeris are taken
Mixing, pulverizing to partial size is 10-25 μm, and Indian Flagellaria glycosides displayed and root of fangji total alkaloid is added, and after mixing evenly, is added
60% white wine heating and refluxing extraction 2h, filtering, obtains filtrate；
(2) it takes filtrate that sucrose is added, after mixing evenly, adjusts pH to 4.5-4.8, the yeast of activation is accessed, at 25 DEG C
Heat-preservation fermentation 8-10 days, filtering obtained fermentation liquid；
(3) after moving into fermentation liquid in fermentation tank, latter ferment 15-20 days at 12-15 DEG C, clarified solution is taken to move into ageing container
In, it is stored 2 months or more at 6-8 DEG C and carries out ageing；
(4) after ageing, tannin is added, stirs evenly, stand 6-8 days, upper layer is taken to clarify wine liquid after precipitating completely
It is filtered the liquid medicine that there is swelling diuretic effect to get the present invention.
The inoculum concentration of the yeast activated in above-mentioned steps (2) is 8-10%.
The dosage of tannin used in above-mentioned steps (4) is the 0.06-0.07 of wine liquid amount.
Comparative example 1
The difference from embodiment 1 is that without addition Indian Flagellaria glycosides displayed in composition of raw materials.
Comparative example 2
The difference from embodiment 1 is that without addition root of fangji total alkaloid in composition of raw materials.
Comparative example 3
The difference from embodiment 1 is that without addition Indian Flagellaria glycosides displayed and root of fangji total alkaloid in composition of raw materials.
Efficacy validation
Diuretic test
Mouse is randomly divided into control group, embodiment 1-5 group and comparative example 1-3 group, control group and gavages same amount of normal saline,
After each group stomach-filling one day, after taking Normal group, embodiment 1-5 group and comparative example 1-3 group to be deprived of food but not water 14 hours, press
0.2ml/20g weight gives mouse gavaging load water, and the slighter compress abdomen after last gastric infusion, remaining urine is drained, immediately by mouse
It is respectively placed in glass bell jar, filter paper is spread in bell jar bottom, removes the mouse faecal pellet on filter paper after 1 hour, is claimed with electronic balance
The gain in weight of filter paper is taken, weighs primary, the observation corresponding data of 5 hour records per hour later, and survey using fluorescence analysis
Determine the content of serotonin in brain tissue, the results are shown in Table 2：
Serotonin comparision contents in 2 each group mouse urine volume of table and brain tissue
| Group | Urine volume (g) | Serotonin (μ g/g) |
| Control group | 0.49 | 0.75 |
| Embodiment 1 | 0.60 | 0.82 |
| Embodiment 2 | 0.61 | 0.83 |
| Embodiment 3 | 0.64 | 0.85 |
| Embodiment 4 | 0.63 | 0.84 |
| Embodiment 5 | 0.61 | 0.82 |
| Comparative example 1 | 0.54 | 0.76 |
| Comparative example 2 | 0.53 | 0.77 |
| Comparative example 3 | 0.55 | 0.79 |
As shown in Table 2, in terms of urine volume, embodiment 1-5 group compared with the control group, has the difference of conspicuousness, and right
Ratio 1-3 group compared with the control group, no significant change, in terms of brain tissue serotonin content, compared with the control group, embodiment
1-5 group can significantly improve brain tissue serotonin content, and comparative example 1-3 group illustrates this compared with the control group without significant change
The liquid medicine with swelling diuretic effect of invention preparation can be improved neurotransmitter content, by adjusting mesencephalic centre nerve, thus
With certain diuresis.
Detumescence test
The Functional edema patient that collects of hospital is chosen as observation object, be randomly divided into control group, embodiment 1-5 group and
Comparative example 1-3 group, control group take 2 days and are discontinued 2 days to Western medicine, and 3 times a day, 3 months are 1 course for the treatment of, observe clinical indices, and
Follow-up half a year after treatment is finished records two groups of recurrences, and the results are shown in Table 3：
It cures：Edema extinction after treatment, in half a year without recurrence；It is effective：It is basic always after treatment to subside, or completely after recession
Have in half a year and put on weight, symptom controls after treatment；Effectively：Symptom disappears substantially after treatment or symptom disappears later six months interior recurrence not
More than 3 times；In vain：Later six months interior recurrence that pretherapy and post-treatment symptom is not improved or oedema disappears 3 times or more.Total effective=healing
+ effective+effectively.
3 each group therapeutic effect of table and recurrence compare
| Group | Number of cases | It cures | It is effective | Effectively | In vain | Total effective rate (%) | (example) is recurred in half a year |
| Control group | 20 | 2 | 2 | 10 | 6 | 70 | 11 |
| Embodiment 1 | 20 | 10 | 5 | 3 | 2 | 90 | 5 |
| Embodiment 2 | 20 | 11 | 4 | 3 | 2 | 90 | 4 |
| Embodiment 3 | 20 | 11 | 5 | 2 | 2 | 90 | 4 |
| Embodiment 4 | 20 | 10 | 5 | 3 | 2 | 90 | 5 |
| Embodiment 5 | 20 | 10 | 6 | 2 | 2 | 90 | 5 |
| Comparative example 1 | 20 | 5 | 3 | 7 | 5 | 75 | 8 |
| Comparative example 2 | 20 | 5 | 4 | 6 | 5 | 75 | 8 |
| Comparative example 3 | 20 | 4 | 5 | 6 | 5 | 75 | 8 |
As shown in Table 3, the healing of embodiment 1-5 group is 50-55%, and total effective rate 90% has compared with the control group
The difference of conspicuousness, embodiment 1-5 group recur only 4-5 after treating half a year, and recurrence rate 20-25% is substantially less than
Control group, difference has statistical significance, and comparative example 1-3 group is compared with the control group, no significant change, illustrates preparation of the present invention
The liquid medicine with swelling diuretic effect can effectively subside oedema, and recurrence rate is low.
In conclusion the liquid medicine prepared by the present invention with swelling diuretic effect can be improved neurotransmitter content, pass through
Adjust mesencephalic centre nerve, urine promoted to generate and discharge, increase the excretion of urine sodium, potassium, the electrolyte such as chlorine, and to renal function without
It influences, and the oedema that can effectively subside, to have good swelling diuretic effect.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention
Protect range.
Claims (8)
1. a kind of liquid medicine with swelling diuretic effect, which is characterized in that composed of the following components：3-5 parts of Indian Flagellaria glycosides displayed,
2-4 parts of root of fangji total alkaloid, 15-20 parts of rhizome of chuanxiong, 15-20 parts of Radix Astragali, 8-12 parts of aster, 10-15 parts of the root bark of white mulberry, semen plantaginis 10-
12 parts, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 8-10 parts of caulis akebiae, 10-15 parts of kuh-seng, 10-15 parts of corn stigma, 10-12 parts of rde bean, Chinese Ixeris 8-12
Part, 600-700 parts of 60% white wine, 250-300 parts of sucrose.
2. a kind of liquid medicine with swelling diuretic effect according to claim 1, which is characterized in that by following components group
At：3.5-4.5 parts of Indian Flagellaria glycosides displayed, 2.5-3.5 parts of root of fangji total alkaloid, 16-19 parts of rhizome of chuanxiong, 16-19 parts of Radix Astragali, aster 9-
11 parts, 11-14 parts of the root bark of white mulberry, 10.5-11.5 parts of semen plantaginis, 9-11 parts of Rhizoma Atractylodis Macrocephalae, 8.5-9.5 parts of caulis akebiae, 11-14 parts of kuh-seng, jade
Rice must 11-14 parts, 10.5-11.5 parts of rde bean, 9-11 parts of Chinese Ixeris, 625-675 parts of 60% white wine, 260-290 parts of sucrose.
3. a kind of liquid medicine with swelling diuretic effect according to claim 1 or 2, which is characterized in that by following components
Composition：4 parts of Indian Flagellaria glycosides displayed, 3 parts of root of fangji total alkaloid, 17 parts of rhizome of chuanxiong, 18 parts of Radix Astragali, 10 parts of aster, 12 parts of the root bark of white mulberry, vehicle
First sub 11 parts, 10 parts of Rhizoma Atractylodis Macrocephalae, 9 parts of caulis akebiae, 13 parts of kuh-seng, 12 parts of corn stigma, 11 parts of rde bean, 10 parts of Chinese Ixeris, 60% white wine 650
Part, 275 parts of sucrose.
4. a kind of liquid medicine with swelling diuretic effect according to claim 1-3, which is characterized in that the palpus
The preparation method of leaf guttiferone glucoside is：
A. it takes Indian Flagellaria to be ground into the particle that granularity is 0.5-1.5cm, is 1 by solid-liquid ratio:8 are added in 50% ethanol solution,
After impregnating 3-5h at 70 DEG C, refluxing extraction 2h is extracted twice, and filtering, combined extract is recovered under reduced pressure ethyl alcohol, obtains concentrate；
B. it takes concentrate that the flocculant of concentrate 2% is added, stirs evenly, staticly settle, centrifuging and taking supernatant uses 0.5mol/L
Sodium hydrate aqueous solution adjust supernatant pH to 9, generate flocculent deposit, centrifugal filtration takes filtrate with the hydrochloric acid of 0.5mol/L
Aqueous solution adjust filtrate pH to；
C. take D101 resin and polyamide by 1:1 mixes dress column, by the extracting solution of above-mentioned purifying by 3g/100ml resin
Upper column quantity upper prop, with the distillation water elution of 4 times of column volumes, then with 20% ethanol elution of 2 times of volumes, then with 70% ethyl alcohol solution
It inhales, takes stripping liquid concentrated, dry, obtain Indian Flagellaria glycosides displayed.
5. a kind of liquid medicine with swelling diuretic effect according to claim 1-3, which is characterized in that described anti-
The preparation method of own total alkaloid is：It takes Fourstamen Stephania Root to be put into beaker, is 1 by solid-liquid ratio:13 are added 55% ethanol solution, shake
It is even, 10min is stood, is put into micro-wave oven and heats, set power as 480W, radiates 1min every time, is spaced re-radiation after 1min
1min, such spaced radiation to 3.5min filter, and repeat to extract once by similarity condition, merge filtrate twice, vacuum distillation is extremely
Without alcohol taste, 1% hydrochloric acid of 10ml is then added, is precipitated after standing 48h with filter paper filtering removal, then adjust filtrate pH with concentrated ammonia liquor
=9, it filters after placing 48h, after taking precipitating dry, is dissolved by heating with 1.5ml acetone, drip 1-2 drop distilled water in the solution to molten
Liquid is micro- turbid, places and is volatilized to solution to get root of fangji total alkaloid is arrived.
6. the method for preparing a kind of liquid medicine with swelling diuretic effect as described in any one in claim 1-5, feature exist
In including the following steps：
(1) rhizome of chuanxiong, Radix Astragali, aster, the root bark of white mulberry, semen plantaginis, Rhizoma Atractylodis Macrocephalae, caulis akebiae, kuh-seng, corn stigma, rde bean and Chinese Ixeris mixing are taken,
Pulverizing to partial size is 10-25 μm, and Indian Flagellaria glycosides displayed and root of fangji total alkaloid is added, and after mixing evenly, it is white to be added 60%
Wine heating and refluxing extraction 2h, filtering, obtains filtrate；
(2) it takes filtrate that sucrose is added, after mixing evenly, adjusts pH to 4.5-4.8, access the yeast of activation, kept the temperature at 25 DEG C
Fermentation 8-10 days, filtering, obtains fermentation liquid；
(3) after moving into fermentation liquid in fermentation tank, latter ferment 15-20 days at 12-15 DEG C, clarified solution is taken to move into ageing container,
It is stored 2 months or more at 6-8 DEG C and carries out ageing；
(4) after ageing, tannin is added, stirs evenly, stand 6-8 days, upper layer clarification wine liquid is taken to carry out after precipitating completely
Filter the liquid medicine that there is swelling diuretic effect to get the present invention.
7. a kind of preparation method of liquid medicine with swelling diuretic effect according to claim 6, which is characterized in that described
The inoculum concentration of the yeast activated in step (2) is 8-10%.
8. a kind of preparation method of liquid medicine with swelling diuretic effect according to claim 4, which is characterized in that described
The dosage of tannin used in step (4) is the 0.06-0.07 of wine liquid amount.
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Citations (1)
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| CN106511634A (en) * | 2016-12-30 | 2017-03-22 | 吉林大学 | Traditional Chinese medicine composition for treating uarthritis and preparation method thereof |
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2018
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511634A (en) * | 2016-12-30 | 2017-03-22 | 吉林大学 | Traditional Chinese medicine composition for treating uarthritis and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 中国科学院广西植物研究所: "《广西植物志》", 31 May 2016, 广西科学技术出版社 * |
| 李菱玲等: "防已利尿作用初步试验 ", 《中药药理与临床》 * |
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