CN104474472B - Buccal lozenge of lectuce tea and its production method with three high drop effect - Google Patents

Buccal lozenge of lectuce tea and its production method with three high drop effect Download PDF

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CN104474472B
CN104474472B CN201410722040.7A CN201410722040A CN104474472B CN 104474472 B CN104474472 B CN 104474472B CN 201410722040 A CN201410722040 A CN 201410722040A CN 104474472 B CN104474472 B CN 104474472B
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CN104474472A (en
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许焕明
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DAXIN COUNTY SCIENCE AND TECHNOLOGY INFORMATION INSTITUTE
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/42—Cucurbitaceae (Cucumber family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Abstract

The invention discloses a kind of buccal lozenge of lectuce tea and its production method with three high drop effect, it is characterised in that：It is made up of the raw material of following parts by weight：Ilex Latifolia Thunb 90-100 parts, Momordica grosvenori 20-30 parts, radix polygonati officinalis 8-12 parts, white crane grass 8-12 parts, persimmon leaves 4-8 parts, turmeric 3-5 parts, kelp 3-5 parts, catharanthus roseus 1-2 parts, nicotinic acid 1-2 parts, menthol 1-2 parts, filler 50-70 parts, lubricant 10-15 parts.Buccal lozenge of lectuce tea of the present invention with three high drop effect also has the characteristics that clearing heat and detoxicating, spleen-benefiting mind-tranquilizing, fat-reducing, suppression cancer anti-cancer with hypoglycemic, reducing blood lipid, hypotensive.

Description

Buccal lozenge of lectuce tea and its production method with three high drop effect
Technical field
The invention belongs to Chinese herbal medicine preparation technology field, and in particular to one kind has lowering blood pressure and blood fat, hypoglycemic effect Buccal lozenge of lectuce tea and its production method.
Background technology
With the raising of economic level in decades and the improvement of material conditions, also there occurs creep for the diet structure of people The change of silentization.The diet of modern via it is past it is simply having adequate food and clothing to nutrition heat surplus type convert, the thing followed is people In terms of health be great cost that this is paid.The disease that past many can only can just be seen with the elderly is such as high Blood pressure, hyperglycaemia, high fat of blood etc. rapidly shift to young and middle-aged colony.It is inclined in order to control and correct these that occur in vivo Difference, there are many people all to have to rely on various medicines to maintain the normal value of health indicator.In order to meet this needs, at present Medical manufacturer developed the hypotensive of many, hypoglycemic and reducing blood lipid chemicals, although these medicines have Much the index of human body is recovered really to serve obvious effect really, but many side effects of the thing followed but give people Bring many new worries.Especially there are many people, there is hypertension, high fat of blood and hyperglycaemia simultaneously with them Symptom, the treatment difficulty for these people and worry in the treatment are just more.Many people spies want to borrow in recent years Help traditional Chinese medicine to release slight illness.Though current existing Chinese medicine can treat hypertension, hyperglycaemia, the medicine of high fat of blood respectively It is so a lot, but the medicine that can treat these three diseases simultaneously is not too much more.
Modern medicine study shows, in Ilex Latifolia Thunb containing bitter leaves saponin, amino acid, vitamin C, Polyphenols, flavonoids, The Multiple components of caffeine, protein etc. 200, have clearing away heat and removing summer, eyesight-improving intelligence-developing, promote the production of body fluid to quench thirst, diuresis cardiac stimulant, the cough-relieving that wets one's whistle, The multiple efficacies such as reducing blood lipid, hypotensive, hypoglycemic, fat-reducing, suppression cancer anti-cancer, anti-aging, promoting blood circulation arteries and veins.It is grinding for tea health-care food Study carefully one of focus, the edible way of tealeaves is more based on bubble drink for a long time, and form is more single, and utilization rate is not high enough, with Traditional bag bubble dissipates bubble and compared, and tealeaves buccal tablet is easy to carry, using simple, can utilize its active ingredient to greatest extent, expire Sufficient modern's nutrition and health care, simple and efficient consumption demand, but due to tea flavour it is too light, mouthfeel is bad the problems such as, cause market Degree of recognition is not high, can not meet the market demand.Therefore, development is a kind of has hypoglycemic, lowering blood pressure and blood fat buccal lozenge of lectuce tea It is very important.
The content of the invention
The purpose of the present invention is to provide one kind for above-mentioned prior art deficiency and have no toxic side effect, and has hypoglycemic, drop Blood fat, hypotensive, also with clearing heat and detoxicating, spleen-benefiting mind-tranquilizing, fat-reducing, the buccal lozenge of lectuce tea and its producer for pressing down cancer protective effect on cancer risk Method.
The present invention is realized using following technical scheme：
The present invention has the buccal lozenge of lectuce tea of three high drop effect, is made up of the raw material of following parts by weight：
Ilex Latifolia Thunb 90-100 parts, Momordica grosvenori 20-30 parts, radix polygonati officinalis 8-12 parts, white crane grass 8-12 parts, persimmon leaves 4-8 Part, turmeric 3-5 parts, kelp 3-5 parts, catharanthus roseus 1-2 parts, nicotinic acid 1-2 parts, menthol 1-2 parts, filler 50-70 parts, Lubricant 10-15 parts.
The above-described buccal lozenge of lectuce tea with three high drop effect, is made up of the raw material of following parts by weight：Ilex Latifolia Thunb 95 parts, 25 parts of Momordica grosvenori, 10 parts of radix polygonati officinalis, white crane grass 10 parts, 6 parts of persimmon leaves, 4 parts of turmeric, 4 parts of kelp, 1 part of catharanthus roseus, nicotinic acid 1 Part, 1 part of menthol, 60 parts of filler, 12 parts of lubricant.
The present invention is by Chinese medicines such as 95 parts of Ilex Latifolia Thunb, Momordica grosvenori, radix polygonati officinalis, white crane grass, persimmon leaves, turmeric, kelp, catharanthus roseus Material forms, and is compounded in conjunction with nicotinic acid and menthol, has hypoglycemic, reducing blood lipid, hypotensive, also pacifies with clearing heat and detoxicating, invigorating the spleen God, fat-reducing, the effect of suppression cancer anti-cancer.
Each medicine effective ingredient analysis of the above-described buccal lozenge of lectuce tea Chinese medicine preparation with three high drop effect：
Ilex Latifolia Thunb,【Alias】Cortex Ilicis Rotundae；【Latin】Ilex latifolia Thunb, Curcurbitaceae, planted for Aquifoliaceae Thing Cortex Ilicis Rotundae（Scientific name：Folium llicis Latifoliae）Leaf, be born in hillside, bamboo grove, bushes.It is distributed in length River downstream each province and Fujian.Ilex Latifolia Thunb is commonly called as tea fourth, Fu Dingcha, highland Lu's tea, is a kind of traditional pure natural health-care beverage of China Good merchantable brand, it is known as the laudatory titles such as " health protection tea ", " cosmetic tea ", " slim tea ", " blood-pressure decreasing tea ", " lengthen one's life tea ".【Nature and flavor】It is sweet, bitter, cold； 【Major function】With clearing away heat and removing summer, eyesight-improving intelligence-developing, promote the production of body fluid to quench thirst, diuresis cardiac stimulant, the cough-relieving that wets one's whistle, reducing blood lipid, hypotensive, drop blood The multiple efficacies such as sugar, fat-reducing, suppression cancer anti-cancer, anti-aging, promoting blood circulation arteries and veins.①《Compendium of Materia Medica》：Ilex Latifolia Thunb has dissipate wind-heat, clear head Mesh, promote the production of body fluid to quench thirst, help digestion refresh oneself, the pharmacological function such as eliminating inflammation and expelling toxin, hypertension and hyperlipemia.②《Book on Chinese herbal medicine is new again》：Eliminate indigestion and phlegm, relieving restlessness stops Yearningly, profit two just, is gone greasy.③《Traditional Chinese Medicine in Sichuan will》：Energy heat-clearing dissipates wind, and relieving restlessness is quenched one's thirst.Control headache, dentalgia, tinnitus, hot eyes and food It is stagnant to have phlegm.
Momordica grosvenori,【Alias】LAHANGUO, balloonvine heartseed herb, Semen Momordicae, invaluable, arhat table, naked tortoise bar；【Latin】 Siraitia grosuenorii, Curcurbitaceae, it is grown in the hillside sylvan life of 300~1400 meters of subtropical zones of height above sea level, river bank moistening location Or in scrub forest, Guangxi Zhuang Autonomous Region Guilin City Yongfu county Longjiang township, dragon victory and hundred Shou Deng towns are mainly originated in,【Nature and flavor】Taste It is sweet cool in nature；【Major function】Clearing profit lung, relieving cough and reducing sputum, laxation toxin expelling.①《The south of the Five Ridges is gathered medicinal herbs record》：Manage phlegm-fire cough, and pig essence Meat decoct soup takes it.②《Guangxi Chinese medicinal herbal》：Cough-relieving heat-clearing, cool blood ease constipation.Control cough, the dry stomach energy constipation of blood etc..Fruits nutrition valency Value is very high, containing abundant vitamin C（Contain 400 milligrams~500 milligrams in every 100 grams of fresh fruits）And glucoside, fructose, glucose, Protein, lipid etc..
Radix polygonati officinalis,【Alias】Luxuriant, female withers, saved land, beautiful art, ring are yellow, seven, bamboo, Latin literary fame：Polygonatum odoratum （Mill.）Druce. the rhizome of Liliaceae herbaceos perennial radix polygonati officinalis.Be distributed in northeast, North China, East China and The ground such as Hubei, Hunan, Guangdong, Zhejiang, Inner Mongol, Anhui.【Nature and flavor】It is sweet, flat,【Major function】Pyreticosis impairment of yin, cough polydipsia, void Labor heating, frequent urination, the paddy that disappears are easily hungry, also with reducing blood lipid, hypotensive, nourish, calm and cardiac stimulant effect.①《The southern regions of the Yunnan Province sheet Grass》：Fill blood, bowl spares invigorating the spleen.②《Guangxi Chinese medicinal herbal》：Nourishiing yin to clear away the lung-heat is moisturized.Control the deficiency of Yin, hidrosis, cough caused by dryness, consumptive lung disease.
White crane grass,【Alias】Hairyvein agrimony, bignose rhinacanthus branchlet and leaf, polyporus lucidus；【Latin】Agrimonia pilosa Ldb. are Herb on the dry ground of rosaceous plant Agrimony, originate in China's Mainland Yunnan, the Guangdong in south China, the band of Guangxi Mountains one, the southeast The ground such as subregion and India.Flavor efficacy：It is bitter, puckery, flat.【Major function】Lung heat, hot cough, breath with cough, pulmonary tuberculosis, esophagus tuberculosis, The diseases such as rhinopathy, bronchitis, laryngitis, hepatopathy, kidney trouble, diabetes.
Persimmon leaves,【Alias】Persimmon leaf；【Latin】Diospyros kaki L.f. Extract, persimmon leaves are that Ebenaceae is tall The leaf of wood plant persimmon；The all widely distributed fruit in China north and south.【Nature and flavor】Bitter, it is cold in nature, it is nontoxic；【Major function】With quenching the thirst Promote the production of body fluid, the lung qi that disappears is swollen, reduce blood pressure, softens blood vessel, the effect to purify the blood with anti-inflammatory.①《Book on Chinese herbal medicine is new again》：Persimmon leaves are controlled cough and told Blood, slake thirst and help produce saliva.②《Classify herbal》：Persimmon leaves control cough and asthma, and the lung qi that disappears is swollen.
Turmeric,【Alias】Root tuber of aromatic turmeric, tripod are fragrant, milli life, yellow ginger；【Latin】Curcuma longa L. perennial herbs Plant；It is distributed in the ground such as Fujian, Guangdong, Guangxi, Yunnan, Tibet.【Nature and flavor】Acrid flavour is bitter, Great Cold, nontoxic,【Major function】It is broken Blood, promoting the circulation of qi, stimulate the menstrual flow, relieve pain, reducing blood lipid.①《Tang materia medica》：Main trusted subordinate ties product, and Zhu is disobedient, lower gas, blood-breaking, except wind-heat, subduing inflammation. ②《Book on Chinese herbal medicine is just》：Except the depressed inflatable of trusted subordinate, cold air dyspepsia pain.③《Modern Practical Chinese medicinal》：For fragrant stomachic tonic, favourable biliary tract And the disinfective action of liver.
Kelp,【Alias】Synthetic fibre cloth, extra large kelp；【Latin】Laminaria japonica Aiesch, it is Laminariaceae plant Sea-tangle（Laminaria japonica Aresch）Or Alariaceae plant kelp（Goose slaps dish）（Ecklonia kurome Okam） Drying thallus.Respectively at the east area of the Liao River, coextensive with eastern and southern Liaoning Province, Shandong, Zhejiang, Fujian and other places.【Nature and flavor】It is salty, tremble with fear,【Major function】With heat-clearing solution Poison, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating strangurtia；Cure mainly the disease such as heat toxin, carbuncle swells, sore, internal carbuncle, red eye, swell pain, damp and hot.①《China People's republic's pharmacopeia》：1. pair thyroid effect：Tool acts on the iodine contained by being due to, caused by iodide.2. decompression is made With：Laminine (Laminine) has antihypertensive effect, and laminine list citrate is injected intravenously to anesthetized rabbit, can make blood pressure Of short duration decline.3. hypoglycemic effect：Contained laminaran 30ml/kg gavages have obvious hypoglycemic work to normal mouse in kelp With when dosage reaches 100mg/kg, blood glucose reduces by 49% after 7 hours.4. reducing blood lipid and anticoagulation：The multiple gavage of laminarin, energy Significantly suppress high fat of blood chicken serum T-CHOL, the content of triglycerides rises, and can reduce the athero- spot of chicken aortic tunica intima The formation and development of block.
Catharanthus roseus,【Alias】Spring when marigold, four, everyday it is new, wild goose is red, 30,000 flowers；【Latin】Catharanthus roseus （L.）G. Don, Apocynaceae；Guangdong, Guangxi, Yunnan etc. save（Autonomous region）Cultivation is more universal..【Nature and flavor】It is sweet, Slight bitter, tremble with fear,【Major function】It is depressured with cool blood, tranquilizing and allaying excitement.For hypertension, burning hot wound, malignant lymphoma, chorion Skin cancer, monocytic leukemia..1. Guangzhou army《Conventional Chinese herbal medicine handbook》：Tranquilizing and allaying excitement, soothing the liver decompression.Control hypertension. ②《Roster of Medicine Plant in Guangxi》：Treating leukemia, lung cancer, chorioepithelioma, lympha tumour.③《Conventional Chinese herbal medicine color atlas》： Treat Hodgkin's disease, malignant tumour.
Nicotinic acid is also referred to as vitamin B3, or nicotinic acid, molecular formula：C6H5NO2, it is heat-resisting, it can distil, there is Intensive Lipid-lowing Effect.It is one of 13 kinds of vitamins needed by human, is a kind of water soluble vitamin, belongs to vitamin B complex.Nicotinic acid is in people Conversion in the body is niacinamide, and niacinamide is the part of cozymase and codehydrogenase Ⅱ, participates in HypercholesterolemicRats, tissue respiration The process of oxidizing process and carbohydrate anaerobic decomposition.
Menthol is a kind of chemical agent, is extracted in leaf and stem by peppermint, white crystal, molecular formula C10H20O, For the main component in peppermint and lavender essential oil.It is used as excitants in medicine, acts on skin or mucous membrane, has refrigerant antipruritic Effect；It is for oral administration to be used as carminative, for headache and nose；Pharynx；Laryngitis etc..Its ester is used for spices and medicine.
The production method that the present invention has the buccal lozenge of lectuce tea of three high drop effect is made in above-mentioned each component medicine, including following Step：
（1）Extractor is poured into after Ilex Latifolia Thunb is crushed in parts by weight, water is added as 10 times of medicine gross weight, heats To 100 DEG C of infusion 1.5-2 hours, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, extract solution A is obtained；
（2）The dregs of a decoction after being filtered in step 1 are added into water as 5 times of medicine gross weight, it is small to be heated to 100 DEG C of infusions 1 When, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution B；
（3）The dregs of a decoction after being filtered in step 2 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 Hour, when fluid temperature is down to 35-50 DEG C, mixes and stir through 120 mesh sieve net filtrations, then extract solution A and extract solution B Mix, the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, is concentrated in vacuo to proportion as 1.3 Concentrate, preserve it is stand-by；
（4）Pour into and carry after in parts by weight crushing Momordica grosvenori, radix polygonati officinalis, white crane grass, persimmon leaves, turmeric, kelp, catharanthus roseus Take tank, add that water is medicine gross weight 10 times, be heated to 100 DEG C of infusion 1.5-2 hours, treat fluid temperature be down to 35 DEG C- At 50 DEG C, through 120 mesh sieve net filtrations, extract solution C is obtained；
（5）The dregs of a decoction after being filtered in step 4 are added into water as 5 times of medicine gross weight, it is small to be heated to 100 DEG C of infusions 1 When, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution D；
（6）The dregs of a decoction after being filtered in step 5 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 Hour, when fluid temperature is down to 35-50 DEG C, mixes through 120 mesh sieve net filtrations, then extract solution C and extract solution D, first add Nicotinic acid and menthol are stirred, and the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, The concentrate that proportion is 1.3 is concentrated in vacuo to, is preserved stand-by.
（7）The concentrate of the concentrate of 60-70% steps 3 and 30-40% steps 6 is poured into material-compound tank and mixed, is added Stirred after filler and wet and slippery dose, be condensed into thick paste and softwood is made；Softwood is crossed into 18 eye mesh screens to be granulated, then Dried under the conditions of 50-60 DEG C, gained particle carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
Above-described ethanol precipitation is to add the ethanol that mass fraction is 80-90% in concentrate, while stirring slowly Addition, being adjusted to closed 2-4 hours when alcohol content is 40-70% in concentrate refilters.
Above-described filler is dextrin, microcrystalline cellulose, converted starch, pregelatinized starch, xylitol, and carboxymethyl forms sediment One or more in powder sodium.
Above-described wet and slippery dose is stearate, talcum powder, hydride vegetable oil, one kind in polyethylene glycol or several Kind.
Buccal lozenge of lectuce tea with three high drop effect, according to different situations and the condition of processing factory, can also be made bitter leaves Tea liquid beverage, bitter leaves tea bag, Ilex Latifolia Thunb particle electuary and other products.
The beneficial effects of the invention are as follows：
1st, pharynx-clearing throat-benefiting buccal lozenge of lectuce tea of the present invention using originate from Guangxi Daxin County Ilex Latifolia Thunb, Guilin Momordica grosvenori etc. Herbaceous plant is refined to be formed, and Ilex Latifolia Thunb, Momordica grosvenori, radix polygonati officinalis, white crane grass, persimmon leaves, turmeric, kelp, catharanthus roseus are entirely medicine food Dual-purpose raw material, has no side effect, no bad smell, and mouthfeel is pure and fresh, natural, tasty and refreshing.
2nd, buccal lozenge of lectuce tea of the present invention is to treatment hypertension, cerebral arteriovenous malformation, reducing blood lipid, hypoglycemic, reduction cholesterol, fertilizer Fat disease, preventing and treating diabetes have quick, special efficacy；Also there is clearing heat and detoxicating, spleen-benefiting mind-tranquilizing, fat-reducing, suppression cancer protective effect on cancer risk；Thorough releasing The hardship of the three high patients serious illness, and the healthy population has been obtained effective health care, it is without any side effects, securely and reliably.
3rd, buccal lozenge of lectuce tea of the present invention adds nicotinic acid, menthol and Momordica grosvenori, makes the micro- sweet tea of buccal lozenge of lectuce tea mouthfeel, salubrious, The bitter taste of Ilex Latifolia Thunb is eliminated, is more liked by three high crowds, also suitable any crowd takes.
4th, the present invention is added into Momordica grosvenori, and modern medicine and pharmacology research finds that Momordica grosvenori contains abundant glucoside, this glucoside Sugariness be 300 times of sweetness of cane sugar, do not produce heat, be beverage, the rare raw material of confectionery industry, be the optimal replacement of sucrose Product, blood glucose is not raised, and there is hypoglycemic effect, auxiliary treatment diabetes can be used for；So it is the food of diabetic Treat good merchantable brand.
5th, material composition of the invention and parts by weight compare by long-term experiment and repeatedly and used, and have shown that science is matched somebody with somebody 5, it is mutually use, inseparable, there is good therapeutic effect.
Embodiment
Embodiment 1：
（One）Raw material and weight：
90 parts of Ilex Latifolia Thunb, 20 parts of Momordica grosvenori, 8 parts of radix polygonati officinalis, 8 parts of white crane grass, 4 parts of persimmon leaves, 3 parts of turmeric, 3 parts of kelp, length 1 part of spring flower, 1 part of nicotinic acid, 1 part of menthol, 50 parts of filler, 10 parts of lubricant.
（Two）Production method：
（1）Extractor is poured into after Ilex Latifolia Thunb is crushed in parts by weight, water is added as 10 times of medicine gross weight, heats To 100 DEG C of infusion 1.5-2 hours, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, extract solution A is obtained；
（2）The dregs of a decoction after being filtered in step 1 are added into water as 5 times of medicine gross weight, it is small to be heated to 100 DEG C of infusions 1 When, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution B；
（3）The dregs of a decoction after being filtered in step 2 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 Hour, when fluid temperature is down to 35-50 DEG C, mixes and stir through 120 mesh sieve net filtrations, then extract solution A and extract solution B Mix, the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, is concentrated in vacuo to proportion as 1.3 Concentrate, preserve it is stand-by；
（4）Pour into and carry after in parts by weight crushing Momordica grosvenori, radix polygonati officinalis, white crane grass, persimmon leaves, turmeric, kelp, catharanthus roseus Take tank, add that water is medicine gross weight 10 times, be heated to 100 DEG C of infusion 1.5-2 hours, treat fluid temperature be down to 35 DEG C- At 50 DEG C, through 120 mesh sieve net filtrations, extract solution C is obtained；
（5）The dregs of a decoction after being filtered in step 4 are added into water as 5 times of medicine gross weight, it is small to be heated to 100 DEG C of infusions 1 When, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution D；
（6）The dregs of a decoction after being filtered in step 5 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 Hour, when fluid temperature is down to 35-50 DEG C, mixes through 120 mesh sieve net filtrations, then extract solution C and extract solution D, first add Nicotinic acid and menthol are stirred, and the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, The concentrate that proportion is 1.3 is concentrated in vacuo to, is preserved stand-by.
（7）The concentrate of the concentrate of 60-70% steps 3 and 30-40% steps 6 is poured into material-compound tank and mixed, is added Stirred after filler and wet and slippery dose, be condensed into thick paste and softwood is made；Softwood is crossed into 18 eye mesh screens to be granulated, then Dried under the conditions of 50-60 DEG C, gained particle carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
Above-described filler is dextrin；Above-described wet and slippery dose is stearate.
Embodiment 2：
（One）Raw material and weight：
95 parts of Ilex Latifolia Thunb, 25 parts of Momordica grosvenori, 10 parts of radix polygonati officinalis, white crane grass 10 parts, 6 parts of persimmon leaves, 4 parts of turmeric, 4 parts of kelp, 1 part of catharanthus roseus, 1 part of nicotinic acid, 1 part of menthol, 60 parts of filler, 12 parts of lubricant.
（Two）Production method：
（1）Extractor is poured into after Ilex Latifolia Thunb is crushed in parts by weight, water is added as 10 times of medicine gross weight, heats To 100 DEG C of infusion 1.5-2 hours, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, extract solution A is obtained；
（2）The dregs of a decoction after being filtered in step 1 are added into water as 5 times of medicine gross weight, it is small to be heated to 100 DEG C of infusions 1 When, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution B；
（3）The dregs of a decoction after being filtered in step 2 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 Hour, when fluid temperature is down to 35-50 DEG C, mixes and stir through 120 mesh sieve net filtrations, then extract solution A and extract solution B Mix, the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, is concentrated in vacuo to proportion as 1.3 Concentrate, preserve it is stand-by；
（4）Pour into and carry after in parts by weight crushing Momordica grosvenori, radix polygonati officinalis, white crane grass, persimmon leaves, turmeric, kelp, catharanthus roseus Take tank, add that water is medicine gross weight 10 times, be heated to 100 DEG C of infusion 1.5-2 hours, treat fluid temperature be down to 35 DEG C- At 50 DEG C, through 120 mesh sieve net filtrations, extract solution C is obtained；
（5）The dregs of a decoction after being filtered in step 4 are added into water as 5 times of medicine gross weight, it is small to be heated to 100 DEG C of infusions 1 When, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution D；
（6）The dregs of a decoction after being filtered in step 5 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 Hour, when fluid temperature is down to 35-50 DEG C, mixes through 120 mesh sieve net filtrations, then extract solution C and extract solution D, first add Nicotinic acid and menthol are stirred, and the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, The concentrate that proportion is 1.3 is concentrated in vacuo to, is preserved stand-by.
（7）The concentrate of the concentrate of 60-70% steps 3 and 30-40% steps 6 is poured into material-compound tank and mixed, is added Stirred after filler and wet and slippery dose, be condensed into thick paste and softwood is made；Softwood is crossed into 18 eye mesh screens to be granulated, then Dried under the conditions of 50-60 DEG C, gained particle carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
Above-described filler is xylitol；Above-described wet and slippery dose is talcum powder.
Embodiment 3：
（One）Raw material and weight：
98 parts of Ilex Latifolia Thunb, 28 parts of Momordica grosvenori, 11 parts of radix polygonati officinalis, white crane grass 11 parts, 7 parts of persimmon leaves, 4 parts of turmeric, 4 parts of kelp, 2 parts of catharanthus roseus, 2 parts of nicotinic acid, 2 parts of menthol, 65 parts of filler, 14 parts of lubricant.
（Two）Production method：
（1）Extractor is poured into after Ilex Latifolia Thunb is crushed in parts by weight, water is added as 10 times of medicine gross weight, heats To 100 DEG C of infusion 1.5-2 hours, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, extract solution A is obtained；
（2）The dregs of a decoction after being filtered in step 1 are added into water as 5 times of medicine gross weight, it is small to be heated to 100 DEG C of infusions 1 When, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution B；
（3）The dregs of a decoction after being filtered in step 2 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 Hour, when fluid temperature is down to 35-50 DEG C, mixes and stir through 120 mesh sieve net filtrations, then extract solution A and extract solution B Mix, the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, is concentrated in vacuo to proportion as 1.3 Concentrate, preserve it is stand-by；
（4）Pour into and carry after in parts by weight crushing Momordica grosvenori, radix polygonati officinalis, white crane grass, persimmon leaves, turmeric, kelp, catharanthus roseus Take tank, add that water is medicine gross weight 10 times, be heated to 100 DEG C of infusion 1.5-2 hours, treat fluid temperature be down to 35 DEG C- At 50 DEG C, through 120 mesh sieve net filtrations, extract solution C is obtained；
（5）The dregs of a decoction after being filtered in step 4 are added into water as 5 times of medicine gross weight, it is small to be heated to 100 DEG C of infusions 1 When, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution D；
（6）The dregs of a decoction after being filtered in step 5 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 Hour, when fluid temperature is down to 35-50 DEG C, mixes through 120 mesh sieve net filtrations, then extract solution C and extract solution D, first add Nicotinic acid and menthol are stirred, and the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, The concentrate that proportion is 1.3 is concentrated in vacuo to, is preserved stand-by.
（7）The concentrate of the concentrate of 60-70% steps 3 and 30-40% steps 6 is poured into material-compound tank and mixed, is added Stirred after filler and wet and slippery dose, be condensed into thick paste and softwood is made；Softwood is crossed into 18 eye mesh screens to be granulated, then Dried under the conditions of 50-60 DEG C, gained particle carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
Above-described filler is sodium carboxymethyl starch；Above-described wet and slippery dose is hydride vegetable oil.
Embodiment 4：
（One）Raw material and weight：
100 parts of Ilex Latifolia Thunb, 30 parts of Momordica grosvenori, 12 parts of radix polygonati officinalis, white crane grass 12 parts, 8 parts of persimmon leaves, 5 parts of turmeric, 5 parts of kelp, 2 parts of catharanthus roseus, 2 parts of nicotinic acid, 2 parts of menthol, 70 parts of filler, 15 parts of lubricant.
（Two）Production method：
（1）Extractor is poured into after Ilex Latifolia Thunb is crushed in parts by weight, water is added as 10 times of medicine gross weight, heats To 100 DEG C of infusion 1.5-2 hours, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, extract solution A is obtained；
（2）The dregs of a decoction after being filtered in step 1 are added into water as 5 times of medicine gross weight, it is small to be heated to 100 DEG C of infusions 1 When, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution B；
（3）The dregs of a decoction after being filtered in step 2 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 Hour, when fluid temperature is down to 35-50 DEG C, mixes and stir through 120 mesh sieve net filtrations, then extract solution A and extract solution B Mix, the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, is concentrated in vacuo to proportion as 1.3 Concentrate, preserve it is stand-by；
（4）Pour into and carry after in parts by weight crushing Momordica grosvenori, radix polygonati officinalis, white crane grass, persimmon leaves, turmeric, kelp, catharanthus roseus Take tank, add that water is medicine gross weight 10 times, be heated to 100 DEG C of infusion 1.5-2 hours, treat fluid temperature be down to 35 DEG C- At 50 DEG C, through 120 mesh sieve net filtrations, extract solution C is obtained；
（5）The dregs of a decoction after being filtered in step 4 are added into water as 5 times of medicine gross weight, it is small to be heated to 100 DEG C of infusions 1 When, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution D；
（6）The dregs of a decoction after being filtered in step 5 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 Hour, when fluid temperature is down to 35-50 DEG C, mixes through 120 mesh sieve net filtrations, then extract solution C and extract solution D, first add Nicotinic acid and menthol are stirred, and the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, The concentrate that proportion is 1.3 is concentrated in vacuo to, is preserved stand-by.
（7）The concentrate of the concentrate of 60-70% steps 3 and 30-40% steps 6 is poured into material-compound tank and mixed, is added Stirred after filler and wet and slippery dose, be condensed into thick paste and softwood is made；Softwood is crossed into 18 eye mesh screens to be granulated, then Dried under the conditions of 50-60 DEG C, gained particle carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea.
Above-described filler is dextrin, microcrystalline cellulose, converted starch and xylitol；Above-described wet and slippery dose is Hydride vegetable oil and polyethylene glycol.
Application Example
The present invention's has the product that the buccal lozenge of lectuce tea of three high drop effect was studied in 2012 and manufactures experimently out to part Crowd is taken, volunteer 30, wherein there is the symptoms such as diabetes, hypertension, high fat of blood.4-8 pieces are taken daily, take 3- After 5 days, three indexs all have what is be decreased obviously to have 27 people, and as a result patient takes rear effective percentage and reaches more than 90%, except 3 Symptom more severe case is needed beyond hospital treatment, and 27 do not spend hospital, also do not take Western medicine.For with serious glycosuria Hypertension, the hyperlipemic patients of disease, coordinate other hypoglycemic drugs, blood pressure, blood fat are obvious while taking medicine of the present invention Decline, the dosage of other hypoglycemic medicines can also reduce 10% to 30%, and glycosylated hemoglobin value is also decreased obviously, and prompt blood glucose Tend to be steady.
Model case
1st, Peng so-and-so, female, 45 years old, in November, 2013 was diagnosed as high fat of blood and coronary heart disease, took Danshen Tablets, brain blood daily The cardiovascular and cerebrovascular disease medicines such as logical, suxiao jiuxin pills, do not feel any better；Through taking the buccal lozenge of lectuce tea of the present invention, 4-8 is taken daily Piece, symptom considerably reduces after 2 days, and after taking a week, blood pressure is steady, examination in hospital after one month, and blood fat index is substantially just Often.
2nd, the Qin so-and-so, man, 55 years old, certain top managers, with diabetes, after the treatment of the large hospitals such as Beijing, Shanghai, effect It is bad, frequent insulin injection and superpower antioxidant therapy, through taking the buccal lozenge of lectuce tea of the present invention, 4-8 pieces are taken daily, Blood pressure, blood glucose decline after 5 days, and glycemic index is normal after continuously taking three courses for the treatment of, are treated without insulin injection.
3rd, Tan, man, 62 years old, because often smoking is drunk beyond one's capacity, with hypertension, high fat of blood and coronary heart disease for many years, through clothes With the buccal lozenge of lectuce tea of the present invention, 4-8 pieces are taken daily, after a course for the treatment of, blood pressure, blood fat are steady, and blood pressure, blood fat are extensive after 30 days It is multiple normal, usually often take, also do not recurred until so far.
4th, Zhang, female, 52 years old, teacher, suffer from diabetes for many years, get up in the night to urinate 7-8 times daily, through the bitter leaves for taking the present invention After one week of tea buccal tablet, number of getting up in the night to urinate daily is reduced to 2-3 times.
5th, Wei, 72 years old, with illnesss such as hypertension, high fat of blood and insomnias for many years, adhere to taking the bitter leaves of the present invention Tea buccal tablet, 3 times a day, contain use 2 every time, sleep after a week normal, hypertension and the decline of high fat of blood index, continue to take After 1 month, blood pressure, blood fat recover normal.

Claims (2)

  1. A kind of 1. buccal lozenge of lectuce tea with three high drop effect, it is characterised in that：It is made up of the raw material of following parts by weight：Bitter leaves Tea 90-100 parts, Momordica grosvenori 20-30 parts, radix polygonati officinalis 8-12 parts, white crane grass 8-12 parts, persimmon leaves 4-8 parts, turmeric 3-5 Part, kelp 3-5 parts, catharanthus roseus 1-2 parts, nicotinic acid 1-2 parts, menthol 1-2 parts, filler 50-70 parts, Lubricant 10-15 parts；
    The production method of the described buccal lozenge of lectuce tea with three high drop effect, include extraction and the arhat of Ilex Latifolia Thunb active ingredient Fruit, the extraction of radix polygonati officinalis, white crane grass, persimmon leaves, turmeric, kelp, catharanthus roseus active ingredient, are comprised the following steps that：
    （1）Extractor is poured into after Ilex Latifolia Thunb is crushed in parts by weight, water is added as 10 times of medicine gross weight, is heated to 100 DEG C of infusion 1.5-2 hours, when fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, obtain extract solution A；
    （2）It is 5 times of medicine gross weight that the dregs of a decoction after being filtered in step 1 are added into water, is heated to 100 DEG C of infusions 1 hour, treats When fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, extract solution B is obtained；
    （3）The dregs of a decoction after being filtered in step 2 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 is small
    When, when fluid temperature is down to 35-50 DEG C, mixed through 120 mesh sieve net filtrations, then extract solution A and extract solution B Stir together, the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation filters after 2-4 hours, is concentrated in vacuo To the concentrate that proportion is 1.3, preserve stand-by；
    （4）Extraction is poured into after in parts by weight crushing Momordica grosvenori, radix polygonati officinalis, white crane grass, persimmon leaves, turmeric, kelp, catharanthus roseus
    Tank, water is added as 10 times of medicine gross weight, is heated to 100 DEG C of infusion 1.5-2 hours, treats that fluid temperature drops During to 35 DEG C -50 DEG C, through 120 mesh sieve net filtrations, extract solution C is obtained；
    （5）It is 5 times of medicine gross weight that the dregs of a decoction after being filtered in step 4 are added into water, is heated to 100 DEG C of infusions 1 hour,
    When fluid temperature is down to 35-50 DEG C, through 120 mesh sieve net filtrations, extract solution D is obtained；
    （6）The dregs of a decoction after being filtered in step 5 are added into water as 3 times of medicine gross weight, are heated to 100 DEG C of infusions 0.5 is small
    When, when fluid temperature is down to 35-50 DEG C, mixed through 120 mesh sieve net filtrations, then extract solution C and extract solution D Close, first add nicotinic acid and menthol stirs, the ethanol for adding 5 times of extract solution weight is precipitated, and ethanol precipitation 2-4 is small When after filter, be concentrated in vacuo to proportion be 1.3 concentrate, preserve it is stand-by；
    （7）The concentrate of the concentrate of 60-70% steps 3 and 30-40% steps 6 is poured into material-compound tank and mixed, is added Stirred after entering filler and wet and slippery dose, be condensed into thick paste and softwood is made；Softwood is crossed into 18 eye mesh screens to be granulated, Then dried under the conditions of 50-60 DEG C, gained particle carries out tabletting, obtains pharynx-clearing throat-benefiting buccal lozenge of lectuce tea；
    Described ethanol precipitation is to add the ethanol that mass fraction is 80-90% in concentrate, is slowly added while stirring, Being adjusted to closed 2-4 hours when alcohol content is 40-70% in concentrate refilters；
    Described filler is dextrin, microcrystalline cellulose, converted starch, pregelatinized starch, xylitol, in sodium carboxymethyl starch It is one or more of；Described wet and slippery dose is the one or more in stearate, talcum powder, hydride vegetable oil, polyethylene glycol.
  2. 2. the buccal lozenge of lectuce tea with three high drop effect according to claim 1, it is characterised in that：By following weight The raw material of number is made：95 parts of Ilex Latifolia Thunb, 25 parts of Momordica grosvenori, 10 parts of radix polygonati officinalis, 10 parts of white crane grass, 6 parts of persimmon leaves, 4 parts of turmeric, elder brother 4 parts of cloth, 1 part of catharanthus roseus, 1 part of nicotinic acid, 1 part of menthol, 60 parts of filler, 12 parts of lubricant.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1370593A (en) * 2002-02-08 2002-09-25 赵宝忠 Ilicis Folium buccal tablet
CN104082480A (en) * 2014-06-19 2014-10-08 谭卓勇 Sugar-free platycodon root tea drink and preparation method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001199996A (en) * 2000-01-24 2001-07-24 Pola Chem Ind Inc ACYL-CoA CHOLESTERYL ACYLTRANSFERASE INHIBITOR AND COMPOSITION COMPRISING THE SAME FOR HYPERLIPIDEMIA

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1370593A (en) * 2002-02-08 2002-09-25 赵宝忠 Ilicis Folium buccal tablet
CN104082480A (en) * 2014-06-19 2014-10-08 谭卓勇 Sugar-free platycodon root tea drink and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
降血脂秘方;iaps;《http://www.360doc.com/content/12/0711/07/7820845_223502113.shtml》;20120711;降血脂秘方3 *

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