CN105055901A - Capsule containing dendrobium officinale and preparation method thereof - Google Patents
Capsule containing dendrobium officinale and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a capsule containing dendrobium officinale and a preparation method of the capsule. The capsule is prepared from the following raw materials in parts by weight: 5-10 parts of dendrobium officinale, 3-8 parts of American ginseng, 5-8 parts of japanese apricot root, 5-10 parts of evening primrose, 3-8 parts of mulberries, and 5-8 parts of Chinese olive. The preparation method of the capsule containing dendrobium officinale comprises the following steps: (1) pretreating the raw materials; (2) mixing; and (3) filling the capsule, namely, filling the capsule with the mixed raw material powder, and thus obtaining the capsule containing dendrobium officinale. The capsule has the efficacies of nourishing Qi and Yin, clearing heat and calming down, clearing damp and eliminating toxins, lowering hyperlipidemia, hypertension and hyperglycemia, and preventing hardening, is free from influences of air humidity, good in absorption, high in bioavailability, and diverse in functions, and the preparation method is simple and easy to operate.
Description
Technical field
The present invention relates to traditional Chinese medicine health-care medicine technical field, especially relate to a kind of capsule containing Herba Dendrobii and preparation method thereof.
Background technology
Herba Dendrobii is orchid, its growth is in the in the shade part of overhanging cliff, root does not bury, and has nourishing Tianjin, health invigorating, strengthens the spleen and stomach, hepatoprotective function of gallbladder promoting, strong muscle blood fat reducing, reduces blood glucose, Tumor suppression, bright eyes, nourishes the effect such as skin and life lengthening.Tang opens in Taoist school's classics " Taoist Scriptures " between the first year and once Herba Dendrobii, Herba Saussureae Involueratae, three double Radix Ginsengs, the hundred Two decades years Radixs Polygoni Multiflori, the Poria of cycle of sixty years, Herba Cistanches, remote mountains Ganoderma, seabed Margarita, Cordyceps was classified as " China's nine large Herba mesonae chinensis ", and Herba Dendrobii is then by first of " nine large Herba mesonae chinensis ".Because peculiar effect of Herba Dendrobii, successive dynasties imperial palace noble regards it as elixir of curing the disease, long-lived good recipe, asks among the people as tribute." Chinese pharmacy dictionary " claim Herba Dendrobii " specially control the gas-liquid of lung stomach, gas-liquid rush prosperous, kidney water is spontaneous ".Be good at Yin-nourishing and body fluid promoting, all diseases for the treatment of Yin and fluid deficiency.Shennong's Herbal is recorded: " the Herba Dendrobii eliminating impediment therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia sea are thin, and reinforcing YIN-essence benefit essence, takes, thick the intestines and stomach for a long time ", claims it to have the effect of " main damaging the spleen and stomach, the eliminating impediment therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia ".It is " YIN nourishing tonification treasure " that the work that will be handed on from age to age " detailed outline is picked up any lost article from the road " of Qing Dynasty well-known doctor Zhao Shuxuan praises Herba Dendrobii.
And existing Herba Dendrobii medicine, mostly be tablet or pill, usually all taste and certain medicine irritation is smelt with the bad of medicine self, and functional comparatively single, simultaneously because granule is comparatively large, enter point laxity after the intestines and stomach, be unfavorable for absorption of human body, simultaneously because medicine directly contacts with air, affect greatly by air humidity, be not easy to long-term preservation.
Summary of the invention
Goal of the invention of the present invention is: to be solved by this invention is exactly that existing Herba Dendrobii medicine mostly is tablet or pill, take inconvenience, absorb slowly, be not easy to long-term preservation, functional single problem, there is provided a kind of from air humidity impact, capsule containing Herba Dendrobii that good absorbing, bioavailability are high and preparation method thereof.
The technical solution used in the present invention is as follows:
Containing a capsule for Herba Dendrobii, the raw material that this capsule comprises following weight portion is made: Herba Dendrobii 5-10 part, Radix Panacis Quinquefolii 3-8 part, Radix Mume 5-8 part, Radix Oenotherae erythrosepalae 5-10 part, Fructus Mori 3-8 part, Fructus Canarii 5-8 part.
Further preferably, the raw material that this capsule comprises following weight portion is made: Herba Dendrobii 6 parts, Radix Panacis Quinquefolii 5 parts, Radix Mume 6 parts, Radix Oenotherae erythrosepalae 7 parts, Fructus Mori 5 parts, Fructus Canarii 7 parts.
The preparation method of the capsule containing Herba Dendrobii as above, comprises the following steps:
(1) pretreatment of raw material:
A: Herba Dendrobii process: by the stem of Herba Dendrobii and flower successively through cleaning, dry, dry after, use pulverizer carry out pulverizing 800-1000 mesh sieve carry out dry sterilization again after for subsequent use;
B: the process of Radix Panacis Quinquefolii: American Ginseng powder is put into supersonic jet mill and pulverizes, obtaining particle diameter, to be less than the Radix Panacis Quinquefolii micropowder of 2 μm for subsequent use;
C: the process of Radix Mume, by use after the section of Radix Mume chopper pulverizer carry out pulverizing 800-1000 mesh sieve carry out dry sterilization again after for subsequent use;
D: the process of Radix Oenotherae erythrosepalae: Radix Oenotherae erythrosepalae is used pulverizer carry out pulverizing 800-1000 mesh sieve carry out dry sterilization again after for subsequent use;
E: the process of Fructus Mori: Fructus Mori saline is cleaned, dry, dry after use pulverizer carry out pulverizing 800-1000 mesh sieve carry out dry sterilization again after for subsequent use;
F: the process of Fructus Canarii: Fructus Canarii is removed seed, sarcocarp is carried out dry rear use pulverizer carry out pulverizing 800-1000 mesh sieve carry out dry sterilization again after for subsequent use;
(2) mixed processing: by raw material for subsequent use for step (1) according to ratio of weight and number mix homogeneously, obtain mixed material powder, for subsequent use;
(3) capsule-filling: be filled in capsule shells by mixed material powder, obtains the capsule containing Herba Dendrobii.
Further illustrate, described drying is in vacuum drier, regulate vacuum drier temperature to be the dried of carrying out 5-10min under 20-25 DEG C of condition.
Further illustrate, the temperature of described oven dry is 30-35 DEG C, moisture content≤5% after oven dry.
Further illustrate, the temperature of described dry sterilization is 90-95 DEG C, and the time of dry sterilization is 5-10min.
Further illustrate, the volumetric concentration of described saline is 15-20%.
In the present invention, the drug effect of each component is as follows:
Fructus Canarii contains protein, fat, carbohydrate, dietary fiber, carotene, looks the compositions such as Fructus Canarii flavol equivalent, vitamin B1, vitamin B2, nicotinic acid, vitamin C, calcium, ferrum, phosphorus, magnesium, zinc, selenium; The acid of Fructus Canarii sweet in the mouth, property is put down, and have heat-clearing and toxic substances removing, sore-throat relieving reduces phlegm, promoting the production of body fluid to quench thirst, appetizing sending down the abnormal ascending QI, and effect of relieving restlessness relieving alcoholic intoxication, is adapted to control laryngopharynx swelling and pain, and cough is spitted blood, the diseases such as summer-heat excessive thirst.
Radix Panacis Quinquefolii sweet and slightly bitter taste, cool in nature, enter cardiopulmonary kidney three warp, lung benefiting is cloudy, clear asthenic fire, promoting the production of body fluid to quench thirst, and supplementary Amplifications of the Compendium of Materia Medica calls it, and " relieving restlessness is tired for tonifying the lung pathogenic fire reducing, born fluid, empty and have fiery person suitable." therefore the people of all hyperactivity of fire caused by deficiency of YIN chronic cough, often with Radix Panacis Quinquefolii then gas put down fire and hold back, he cough is gradually put down.
Radix Mume, micro-hardship, is slightly cold, liver, and gallbladder meridian has expelling wind and removing dampness, heat-clearing and toxic substances removing, cholecystitis, scrofula.
Radix Oenotherae erythrosepalae can treat various diseases, regulate lipid material in blood, the diseases such as the coronary ligation caused hypercholesterolemia, hyperlipidemia, atherosis and cerebral thrombosis have significant curative effect, blood fat reducing and study of anti-atherogenic effect, fat-reducing, anti-fatty liver, antiarrhythmic effect, antiinflammatory.
Fructus Mori is the fruit ear of moraceae plants Mulberry.When Fructus Mori is tender, color is blue or green, and sour in the mouth, time aging, color purple is black, succulence, and taste is sweet.Ripe Mulberry fruit is nutritious, rich in proteins, fat, cellulose, carbohydrate, ash, carotene, thiamine, riboflavin, vitamin E, potassium, zinc, copper, selenium, in addition, also containing tannic acid, malic acid, vitamin C and fatty acid etc., Fructus Mori are that middle-aged and elderly people is healthy and strong U.S. face, antidotal good fruit and good medicine; Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent; Fructus Mori have immunologic enhancement.Fructus Mori have effect of gain to spleen, have potentiation to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism; And to diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenias, there is auxiliary effect.
The present invention take Herba Dendrobii as monarch drug, enriching yin and nourishing kidney, with Fructus Mori, Radix Mume, Radix Oenotherae erythrosepalae, Radix Panacis Quinquefolii and Fructus Canarii for ministerial drug, and Fructus Canarii, Radix Mume, the flat gas of Radix Panacis Quinquefolii heat clearing away, damp eliminating is detoxified, relieving cough and resolving phlegm; Fructus Mori, Radix Oenotherae erythrosepalae as accessory drugs, blood sugar lowering blood fat and blood pressure, anti-sclerosis; Thus reach reinforcing both QI and YIN, the flat gas of heat clearing away, damp eliminating removing toxic substances, fall the effect of " three-hypers ", anti-sclerosis.
Capsule containing Herba Dendrobii of the present invention, selects capsule form to pack, can affect from air humidity, absorption of human body is good, bioavailability is high, possess various effects of above-mentioned raw materials simultaneously, take better effects if simultaneously.
Capsule containing Herba Dendrobii of the present invention, carry out effect experiment in conjunction with animal, laboratory report is as follows:
Choose the capsule 0.6 containing Herba Dendrobii and 1.2g/kgbw/d, every day 1 time, for three days on end, have hypoglycemic activity to normal mouse; This medicine 0.15,0.3,0.6g/kgbw/d has obvious hypoglycemic activity to the diabetes rat formed with streptozotocin, act on relevant with dosage, dose-effect relationship is good; Show the time-effect relationship research of diabetes rat hypoglycemic activity, namely occur obvious hypoglycemic activity containing half an hour after the capsule 0.3g/kgbw/d of Herba Dendrobii, single administration effect can maintain more than 12 hours; Containing Herba Dendrobii capsule 0.3,0.6,1.2g/kgbw/d, once a day, for three days on end, all have obvious hypoglycemic activity to Mouse Kidney upper parathyrine hyperglycemia, act on relevant with dosage; The result of carbohydrate tolerance test shows, containing Herba Dendrobii capsule 0.15,0.3,0.6g/kgbw/d can improve the carbohydrate tolerance of normal rabbits; Because capsule is not sugary, taking of diabetics preferably; This experiment is in particular in following several respects:
(1) testing result of the body weight of laboratory animal, thymus/body weight ratio and spleen/body weight ratio shows, under this experiment condition, tested capsule 's content 166.7mg/kgbw/d, 333.3mg/kgbw/d, 666.6mg/5kgbw/d containing Herba Dendrobii, be equivalent to 6 times of human body recommended intake, 12 times, 22 multiple dose time, obvious impact is had no on the body weight of animal, thymus/body weight ratio and spleen/body weight ratio;
(2) the mouse spleen lymphocyte conversion test result of ConA induction shows, under this experiment condition, the tested capsule 's content containing Herba Dendrobii, at 666.6mg/kgbw/d, when being equivalent to 23 multiple dose of human body recommended intake, has the effect strengthening mouse cell immunologic function;
(3) dinitrofluorobenzene inducing mouse delayed allergy result of the test shows, under this experiment condition, the tested capsule 's content 666.6mg/kgbw/d containing Herba Dendrobii, when being equivalent to 25 multiple dose of human body recommended intake, has the effect strengthening mouse cell immunologic function;
(4) antibody-producting cell detection experiment result shows, under this experiment condition, the tested capsule 's content containing Herba Dendrobii is at 333.3mg/kgbw/d, 666.6mg/kgbw/d, when being equivalent to 11 times of human body recommended intake and 23 multiple dose respectively, there is the effect strengthening mouse humoral immune function;
(5) serolysin test measurement result shows, under this experiment condition, the tested capsule 's content containing Herba Dendrobii is at 333.3mg/kgbw/d, 666.6mg/kgbw/d, when being equivalent to 12 times of human body recommended intake and 23 multiple dose respectively, there is the effect strengthening mouse humoral immune function;
(6) mice carbonic clearance result of the test shows, under this experiment condition, the tested capsule 's content containing Herba Dendrobii is at 333.3mg/kgbw/d, 666.6mg/kgbw/d, when being equivalent to 10 times of human body recommended intake and 21 multiple dose respectively, there is the effect strengthening mononuclear phagocyte phagocytosis in mice;
(7) Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell result of the test and is shown, under this experiment condition, tested capsule 's content 166.7mg/kgbw/d, 333.3mg/kgbw/d, 666.6mg/kgbw/d containing Herba Dendrobii, when being equivalent to 6 times of human body recommended intake, 11 times and 22 multiple dose respectively, there is the effect of stronger macrophage phagocytosis of mice;
(8) NK cytoactive detection result of the test shows, under this experiment condition, the tested capsule containing Herba Dendrobii, at 666.6mg/kgbw/d, when being equivalent to 25 multiple dose of human body recommended intake, has the effect strengthening NK cytoactive.
Here takes the clinical trial statistics of the present invention containing the capsule conditioning above-mentioned symptom state of Herba Dendrobii:
One, typical case's " three-hypers " case
1, Liao so-and-so, man, 51 years old, is diagnosed as hyperlipidemia in November, 2014 and holds concurrently coronary heart disease, takes the cardiovascular and cerebrovascular disease medicines such as Radix Salviae Miltiorrhizae Tabellae, brain blood are logical, SUXIAO JIUXIN WAN every day, does not feel any better; Through taking the capsule containing Herba Dendrobii of the present invention, take 4-8 grain every day, after 2 days, symptom greatly alleviates, and after taking a week, blood pressure is steady, and examination in hospital after month, blood fat index is normal.
2, so-and-so is paid, man, 58 years old, certain top managers, suffer from diabetes, after the treatment of the large hospital such as Beijing, Shanghai, poor effect, frequent insulin injection and superpower antioxidant therapy, through taking the capsule containing Herba Dendrobii of the present invention, take 4-8 grain every day, after 5 days, blood pressure, blood glucose decline, after taking three courses for the treatment of continuously, glycemic index is normal, treats without the need to insulin injection.
3, the Qin, female, 52 years old, because of insobriety of often smoking, suffers from hypertension, hyperlipidemia and coronary heart disease for many years, through taking the capsule containing Herba Dendrobii of the present invention, take 4-8 grain every day, after the course for the treatment of, blood pressure, blood fat are steady, after 30 days, blood pressure, blood fat recover normal, often take at ordinary times, until also do not recur so far.
Two, damp and hot case:
180 routine patients are treated, wherein male 93 example, women 87 example; Age 15-47 year, 31.2 years old mean age ,-20 years January of the course of disease, average course of disease 10 years; Onset case 31 example, recurrent cases 70 example.The phase of carrying out 110 example, resting stage 70 is routine.
Clinical recovery standard: fully recover for improvement rate >=90%, effective is improvement rate >=60%, and progressive is improvement rate >=25%, and invalid is improvement rate < 25%, and effective percentage adds effective calculating with recovery from illness.
Therapeutic scheme: oral pyretic toxicity capsule 4,3 times/d, 1 month is 1 course for the treatment of, judges curative effect after 2 courses for the treatment of.Treatments period should keep happy, the pungent irritable food of fasting, seafood and beef and mutton.
Result:
Three, cirrhosis case test:
Between in October ,-2014 in May, 2007, inventor collects ward and the out-patient of 130 routine liver cirrhosis altogether in ocean, Yantai hospital, wherein man 69 example, female 61 example, age 43-85 year, course of disease 0.5-2.Test group 100 example, matched group 30 example is divided into by complete randomly assigne.Two groups of patient age, sex, cardinal symptom, courses of disease etc., relatively all without significant difference, have comparability.
1, test method
1.1 Therapeutic Method
Test group: take the drop pill that optimization formula of the present invention is obtained, every day 3 times 30 days is a course for the treatment of;
Matched group: taking liver-benefiting dropping pill (Yantai Dayang Pharmaceutical C0. Ltd's production), take according to its description usage and dosage, 30 days is a course for the treatment of.
1.2 observation items: observe inquiry: weak, loss of appetite, abdominal distention, suffer from diarrhoea, the symptomatic condition such as to become thin; Image check: hepatomegaly, splenomegaly, ascites degree; Chemical examination: bilirubin, ALT, AST, GGT, routine blood test.
1.3 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
2, therapeutic outcome
Table 1 liang group comparitive study
Visible, the medicine that the preferred embodiment for the present invention obtains can safe and effective treatment liver cirrhosis.
In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows: the capsule containing Herba Dendrobii of the present invention, can affect from air humidity, drug effect is not single, take rear good absorbing, bioavailability is high, reinforcing both QI and YIN, the flat gas of heat clearing away, damp eliminating removing toxic substances can be reached by taking the capsule containing Herba Dendrobii prepared by the present invention, fall the therapeutic effect of " three-hypers ", anti-sclerosis.
Detailed description of the invention
Below by way of specific embodiment, the invention will be further described.The present invention is not limited to following detailed description of the invention.
Embodiment 1:
Containing a capsule for Herba Dendrobii, the raw material that this capsule comprises following weight portion is made: Herba Dendrobii 5 parts, Radix Panacis Quinquefolii 3 parts, Radix Mume 5 parts, Radix Oenotherae erythrosepalae 5 parts, Fructus Mori 3 parts, Fructus Canarii 5 parts.
Apply above material rate preparation containing the method for the capsule of Herba Dendrobii, comprise the following steps:
(1) pretreatment of raw material:
A: Herba Dendrobii process: the stem of Herba Dendrobii and flower successively being carried out under cleaning, regulating vacuum drier temperature to be 20 DEG C of conditions in vacuum drier the dried of 5min, drying to moisture content under temperature is 30 DEG C of conditions is 5%, then use pulverizer carry out pulverizing 800 mesh sieves under temperature is 90 DEG C of conditions, carry out 5min dry sterilization again after for subsequent use;
B: the process of Radix Panacis Quinquefolii: American Ginseng powder is put into supersonic jet mill and pulverizes, obtaining particle diameter, to be less than the Radix Panacis Quinquefolii micropowder of 2 μm for subsequent use;
C: the process of Radix Mume, by use after the section of Radix Mume chopper pulverizer carry out pulverizing 800 mesh sieves under temperature is 90 DEG C of conditions, carry out 5min dry sterilization again after for subsequent use;
D: the process of Radix Oenotherae erythrosepalae: Radix Oenotherae erythrosepalae is used pulverizer carry out pulverizing 800 mesh sieves under temperature is 90 DEG C of conditions, carry out 5min dry sterilization again after for subsequent use;
E: the process of Fructus Mori: by Fructus Mori volumetric concentration be 15% saline clean, in vacuum drier, regulate vacuum drier temperature to be 20 DEG C of conditions under carry out 5min dried, dry to moisture content to 5% under temperature is 30 DEG C of conditions, then use pulverizer carry out pulverizing 800 mesh sieves under temperature is 90 DEG C of conditions, carry out 5min dry sterilization again after for subsequent use;
F: the process of Fructus Canarii: Fructus Canarii is removed seed, dries to for subsequent use after using after moisture content to 5% pulverizer to carry out to pulverize 800 mesh sieves to carry out 5min dry sterilization again under temperature is 90 DEG C of conditions under temperature is 30 DEG C of conditions by sarcocarp;
(2) mixed processing: by raw material for subsequent use for step (1) according to ratio of weight and number mix homogeneously, obtain mixed material powder, for subsequent use;
(3) capsule-filling: be filled in capsule shells by mixed material powder, obtains the capsule containing Herba Dendrobii.
Embodiment 2:
Containing a capsule for Herba Dendrobii, the raw material that this capsule comprises following weight portion is made: Herba Dendrobii 6 parts, Radix Panacis Quinquefolii 5 parts, Radix Mume 6 parts, Radix Oenotherae erythrosepalae 7 parts, Fructus Mori 5 parts, Fructus Canarii 7 parts.
Apply above material rate preparation containing the method for the capsule of Herba Dendrobii, comprise the following steps:
(1) pretreatment of raw material:
A: Herba Dendrobii process: the stem of Herba Dendrobii and flower successively carried out under cleaning, regulating vacuum drier temperature to be 25 DEG C of conditions in vacuum drier the dried of 10min, dry to moisture content to 4% under temperature is 35 DEG C of conditions, then use pulverizer carry out pulverizing 1000 mesh sieves under temperature is 95 DEG C of conditions, carry out 10min dry sterilization again after for subsequent use;
B: the process of Radix Panacis Quinquefolii: American Ginseng powder is put into supersonic jet mill and pulverizes, obtaining particle diameter, to be less than the Radix Panacis Quinquefolii micropowder of 2 μm for subsequent use;
C: the process of Radix Mume, by use after the section of Radix Mume chopper pulverizer carry out pulverizing 1000 mesh sieves under temperature is 95 DEG C of conditions, carry out 10min dry sterilization again after for subsequent use;
D: the process of Radix Oenotherae erythrosepalae: Radix Oenotherae erythrosepalae is used pulverizer carry out pulverizing 1000 mesh sieves under temperature is 95 DEG C of conditions, carry out 10min dry sterilization again after for subsequent use;
E: the process of Fructus Mori: by Fructus Mori volumetric concentration be 20% saline clean, in vacuum drier, regulate vacuum drier temperature to be 25 DEG C of conditions under carry out 10min dried, dry to moisture content to 4% under temperature is 35 DEG C of conditions, then use pulverizer carry out pulverizing 1000 mesh sieves under temperature is 95 DEG C of conditions, carry out 10min dry sterilization again after for subsequent use;
F: the process of Fructus Canarii: Fructus Canarii is removed seed, dries to for subsequent use after using after moisture content to 4% pulverizer to carry out to pulverize 1000 mesh sieves to carry out 10min dry sterilization again under temperature is 95 DEG C of conditions under temperature is 35 DEG C of conditions by sarcocarp;
(2) mixed processing: by raw material for subsequent use for step (1) according to ratio of weight and number mix homogeneously, obtain mixed material powder, for subsequent use;
(3) capsule-filling: be filled in capsule shells by mixed material powder, obtains the capsule containing Herba Dendrobii.
Embodiment 3:
Containing a capsule for Herba Dendrobii, the raw material that this capsule comprises following weight portion is made: Herba Dendrobii 10 parts, Radix Panacis Quinquefolii 8 parts, Radix Mume 8 parts, Radix Oenotherae erythrosepalae 10 parts, Fructus Mori 8 parts, Fructus Canarii 8 parts.
Apply above material rate preparation containing the method for the capsule of Herba Dendrobii, comprise the following steps:
(1) pretreatment of raw material:
A: Herba Dendrobii process: the stem of Herba Dendrobii and flower successively carried out under cleaning, regulating vacuum drier temperature to be 21 DEG C of conditions in vacuum drier the dried of 6min, dry to moisture content to 3% under temperature is 31 DEG C of conditions, then use pulverizer carry out pulverizing 900 mesh sieves under temperature is 91 DEG C of conditions, carry out 6min dry sterilization again after for subsequent use;
B: the process of Radix Panacis Quinquefolii: American Ginseng powder is put into supersonic jet mill and pulverizes, obtaining particle diameter, to be less than the Radix Panacis Quinquefolii micropowder of 2 μm for subsequent use;
C: the process of Radix Mume, by use after the section of Radix Mume chopper pulverizer carry out pulverizing 900 mesh sieves under temperature is 91 DEG C of conditions, carry out 6min dry sterilization again after for subsequent use;
D: the process of Radix Oenotherae erythrosepalae: Radix Oenotherae erythrosepalae is used pulverizer carry out pulverizing 900 mesh sieves under temperature is 91 DEG C of conditions, carry out 6min dry sterilization again after for subsequent use;
E: the process of Fructus Mori: by Fructus Mori volumetric concentration be 16% saline clean, in vacuum drier, regulate vacuum drier temperature to be 21 DEG C of conditions under carry out 6min dried, dry to moisture content to 3% under temperature is 31 DEG C of conditions, then use pulverizer carry out pulverizing 900 mesh sieves under temperature is 91 DEG C of conditions, carry out 6min dry sterilization again after for subsequent use;
F: the process of Fructus Canarii: Fructus Canarii is removed seed, dries to for subsequent use after using after moisture content to 3% pulverizer to carry out to pulverize 900 mesh sieves to carry out 6min dry sterilization again under temperature is 91 DEG C of conditions under temperature is 31 DEG C of conditions by sarcocarp;
(2) mixed processing: by raw material for subsequent use for step (1) according to ratio of weight and number mix homogeneously, obtain mixed material powder, for subsequent use;
(3) capsule-filling: be filled in capsule shells by mixed material powder, obtains the capsule containing Herba Dendrobii.
Embodiment 4:
Containing a capsule for Herba Dendrobii, the raw material that this capsule comprises following weight portion is made: Herba Dendrobii 7 parts, Radix Panacis Quinquefolii 4 parts, Radix Mume 7 parts, Radix Oenotherae erythrosepalae 6 parts, Fructus Mori 4 parts, Fructus Canarii 6 parts.
Apply above material rate preparation containing the method for the capsule of Herba Dendrobii, comprise the following steps:
(1) pretreatment of raw material:
A: Herba Dendrobii process: the stem of Herba Dendrobii and flower successively carried out under cleaning, regulating vacuum drier temperature to be 22 DEG C of conditions in vacuum drier the dried of 7min, dry to moisture content to 2% under temperature is 32 DEG C of conditions, then use pulverizer carry out pulverizing 800 mesh sieves under temperature is 92 DEG C of conditions, carry out 7min dry sterilization again after for subsequent use;
B: the process of Radix Panacis Quinquefolii: American Ginseng powder is put into supersonic jet mill and pulverizes, obtaining particle diameter, to be less than the Radix Panacis Quinquefolii micropowder of 2 μm for subsequent use;
C: the process of Radix Mume, by use after the section of Radix Mume chopper pulverizer carry out pulverizing 1000 mesh sieves under temperature is 92 DEG C of conditions, carry out 7min dry sterilization again after for subsequent use;
D: the process of Radix Oenotherae erythrosepalae: Radix Oenotherae erythrosepalae is used pulverizer carry out pulverizing 1000 mesh sieves under temperature is 92 DEG C of conditions, carry out 7min dry sterilization again after for subsequent use;
E: the process of Fructus Mori: by Fructus Mori volumetric concentration be 17% saline clean, in vacuum drier, regulate vacuum drier temperature to be 23 DEG C of conditions under carry out 7min dried, dry to moisture content to 3% under temperature is 33 DEG C of conditions, then use pulverizer carry out pulverizing 800 mesh sieves under temperature is 93 DEG C of conditions, carry out 7min dry sterilization again after for subsequent use;
F: the process of Fructus Canarii: Fructus Canarii is removed seed, dries to for subsequent use after using after moisture content to 4% pulverizer to carry out to pulverize 800 mesh sieves to carry out 7min dry sterilization again under temperature is 93 DEG C of conditions under temperature is 33 DEG C of conditions by sarcocarp;
(2) mixed processing: by raw material for subsequent use for step (1) according to ratio of weight and number mix homogeneously, obtain mixed material powder, for subsequent use;
(3) capsule-filling: be filled in capsule shells by mixed material powder, obtains the capsule containing Herba Dendrobii.
Embodiment 5:
Containing a capsule for Herba Dendrobii, the raw material that this capsule comprises following weight portion is made: Herba Dendrobii 9 parts, Radix Panacis Quinquefolii 7 parts, Radix Mume 6 parts, Radix Oenotherae erythrosepalae 9 parts, Fructus Mori 7 parts, Fructus Canarii 6 parts.
Apply above material rate preparation containing the method for the capsule of Herba Dendrobii, comprise the following steps:
(1) pretreatment of raw material:
A: Herba Dendrobii process: the stem of Herba Dendrobii and flower successively carried out under cleaning, regulating vacuum drier temperature to be 24 DEG C of conditions in vacuum drier the dried of 9min, dry to moisture content to 2% under temperature is 34 DEG C of conditions, then use pulverizer carry out pulverizing 800 mesh sieves under temperature is 94 DEG C of conditions, carry out 9min dry sterilization again after for subsequent use;
B: the process of Radix Panacis Quinquefolii: American Ginseng powder is put into supersonic jet mill and pulverizes, obtaining particle diameter, to be less than the Radix Panacis Quinquefolii micropowder of 2 μm for subsequent use;
C: the process of Radix Mume, by use after the section of Radix Mume chopper pulverizer carry out pulverizing 1000 mesh sieves under temperature is 94 DEG C of conditions, carry out 9min dry sterilization again after for subsequent use;
D: the process of Radix Oenotherae erythrosepalae: Radix Oenotherae erythrosepalae is used pulverizer carry out pulverizing 800 mesh sieves under temperature is 94 DEG C of conditions, carry out 9min dry sterilization again after for subsequent use;
E: the process of Fructus Mori: by Fructus Mori volumetric concentration be 18% saline clean, in vacuum drier, regulate vacuum drier temperature to be 24 DEG C of conditions under carry out 9min dried, dry to moisture content to 5% under temperature is 30-35 DEG C of condition, then use pulverizer carry out pulverizing 900 mesh sieves under temperature is 94 DEG C of conditions, carry out 9min dry sterilization again after for subsequent use;
F: the process of Fructus Canarii: Fructus Canarii is removed seed, dries to for subsequent use after using after moisture content to 4% pulverizer to carry out to pulverize 1000 mesh sieves to carry out 5-10min dry sterilization again under temperature is 94 DEG C of conditions under temperature is 34 DEG C of conditions by sarcocarp;
(2) mixed processing: by raw material for subsequent use for step (1) according to ratio of weight and number mix homogeneously, obtain mixed material powder, for subsequent use;
(3) capsule-filling: be filled in capsule shells by mixed material powder, obtains the capsule containing Herba Dendrobii.
The present invention is not limited to aforesaid detailed description of the invention.The present invention expands to any new feature of disclosing in this manual or any new combination raw materials, and the step of the arbitrary new method disclosed or process or any combination newly.
Claims (7)
1., containing a capsule for Herba Dendrobii, it is characterized in that, the raw material that this capsule comprises following weight portion is made: Herba Dendrobii 5-10 part, Radix Panacis Quinquefolii 3-8 part, Radix Mume 5-8 part, Radix Oenotherae erythrosepalae 5-10 part, Fructus Mori 3-8 part, Fructus Canarii 5-8 part.
2. the capsule containing Herba Dendrobii according to claim 1, it is characterized in that, the raw material that this capsule comprises following weight portion is made: Herba Dendrobii 6 parts, Radix Panacis Quinquefolii 5 parts, Radix Mume 6 parts, Radix Oenotherae erythrosepalae 7 parts, Fructus Mori 5 parts, Fructus Canarii 7 parts.
3. the preparation method of the capsule containing Herba Dendrobii according to claim 1 and 2, is characterized in that, comprise the following steps:
(1) pretreatment of raw material:
A: Herba Dendrobii process: by the stem of Herba Dendrobii and flower successively through cleaning, dry, dry after, use pulverizer carry out pulverizing 800-1000 mesh sieve carry out dry sterilization again after for subsequent use;
B: the process of Radix Panacis Quinquefolii: American Ginseng powder is put into supersonic jet mill and pulverizes, obtaining particle diameter, to be less than the Radix Panacis Quinquefolii micropowder of 2 μm for subsequent use;
C: the process of Radix Mume, by use after the section of Radix Mume chopper pulverizer carry out pulverizing 800-1000 mesh sieve carry out dry sterilization again after for subsequent use;
D: the process of Radix Oenotherae erythrosepalae: Radix Oenotherae erythrosepalae is used pulverizer carry out pulverizing 800-1000 mesh sieve carry out dry sterilization again after for subsequent use;
E: the process of Fructus Mori: Fructus Mori saline is cleaned, dry, dry after use pulverizer carry out pulverizing 800-1000 mesh sieve carry out dry sterilization again after for subsequent use;
F: the process of Fructus Canarii: Fructus Canarii is removed seed, sarcocarp is carried out dry rear use pulverizer carry out pulverizing 800-1000 mesh sieve carry out dry sterilization again after for subsequent use;
(2) mixed processing: by raw material for subsequent use for step (1) according to ratio of weight and number mix homogeneously, obtain mixed material powder, for subsequent use;
(3) capsule-filling: be filled in capsule shells by mixed material powder, obtains the capsule containing Herba Dendrobii.
4. the preparation method of the capsule containing Herba Dendrobii according to claim 3, it is characterized in that, described drying is in vacuum drier, regulate vacuum drier temperature to be the dried of carrying out 5-10min under 20-25 DEG C of condition.
5. the preparation method of the capsule containing Herba Dendrobii according to claim 3, it is characterized in that, the temperature of described oven dry is 30-35 DEG C, moisture content≤5% after oven dry.
6. the preparation method of the capsule containing Herba Dendrobii according to claim 3, it is characterized in that, the temperature of described dry sterilization is 90-95 DEG C, and the time of dry sterilization is 5-10min.
7. the preparation method of the capsule containing Herba Dendrobii according to claim 3, it is characterized in that, the volumetric concentration of described saline is 15-20%.
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| CN105748947A (en) * | 2016-05-23 | 2016-07-13 | 吴子平 | Dendrobium officinale compound capsule and preparation method thereof |
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