CN107495350A - A kind of health food and preparation method with function of physical fatigue alleviation - Google Patents
A kind of health food and preparation method with function of physical fatigue alleviation Download PDFInfo
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Abstract
The invention discloses a kind of health food with function of physical fatigue alleviation, is made up by weight ratio of the fruit of Chinese wolfberry 300 500, ganoderma lucidum 280 480, gynostemma pentaphylla 250 420, American Ginseng 100 250, cervus elaphus linnaeus powder 10 120.The present invention combines modern pharmacological research from traditional Chinese medicine traditional theory, and human body physiological state is adjusted by nourishing liver and kidney, supplementing qi and nourishing yin, so as to reach the purpose for alleviating physical fatigue.The present invention is process according to the technique such as property, extracted, concentration of ingredients active ingredient, both ensure that the abundant extraction of effective component, has been decreased the dose of medicine.This product uses capsule simultaneously, had not only masked the poor taste of Chinese medicine but also had been easy to carry, and can preferably be esthetically acceptable to the consumers.Prove that this product is safe and effective by toxicology test, animal function test, can be eaten for a long time.The invention also discloses a kind of preparation method of the health food with function of physical fatigue alleviation.
Description
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of health food with function of physical fatigue alleviation
And preparation method.
Background technology
Fatigue is 21 century to endanger one of principal element of human health, is the primary performance of inferior health, and modern
The true reflection of one of nervous animation.As a kind of physiological phenomenon, fatigue is a kind of machine of protectiveness for the mankind
System, is that body sends the signal that rest.Nowadays because people's rhythm of life is accelerated, many people subject larger for a long time
Psychological pressure or in overtime excess load work state, for a long time the function of body vitals will lack of proper care, so as to produce
A series of fatigue symptoms such as burnout, giddy, limbs fatigue, listless, failure of memory.Medical expert points out, continues excessively
Fatigue can cause a series of ill symptomses, produce " fatigue syndrome ".Fatigue is source of ten thousand diseases, and it can cause oxygen radical to accumulate
Poly-, immunologic hypofunction etc., disease will be comed one after another in the course of time, have a strong impact on people's normal work and life.Therefore, have
The health food for having function of physical fatigue alleviation has been to be concerned by more and more people.The center of gravity of modern medicine is had shifted towards to shape before disease
The intervention of state and effective strick precaution of disease, and traditional Chinese medicine shows unique characteristics in terms of the adjustment to body allomeric function state, in
Medicine is that the health food with function of physical fatigue alleviation has irreplaceable advantage made of raw material.It is effective to alleviate muscle power
The health food of fatigue function is increasingly valued by people and welcome.
The content of the invention
It is an object of the invention to provide a kind of health food with function of physical fatigue alleviation.
It is a further object to provide a kind of preparation method of the health food with function of physical fatigue alleviation.
The present invention adopts the following technical scheme that：
A kind of health food with function of physical fatigue alleviation, it is made up by weight ratio of following raw materials according：
Fruit of Chinese wolfberry 300-500 ganoderma lucidum 280-480 gynostemma pentaphylla 250-420
American Ginseng 100-250 cervus elaphus linnaeus powder 10-120.
Further, it is preferable to match：
Fruit of Chinese wolfberry 320-480 ganoderma lucidum 300-450 gynostemma pentaphylla 280-400
American Ginseng 120-220 cervus elaphus linnaeus powder 20-100.
Further, it is preferable to match：
Fruit of Chinese wolfberry 380-450 ganoderma lucidum 350-420 gynostemma pentaphylla 300-380
American Ginseng 150-200 cervus elaphus linnaeus powder 30-80.
Further, it is preferable to match：
The gynostemma pentaphylla 340 of 420 ganoderma lucidum of the fruit of Chinese wolfberry 380
The cervus elaphus linnaeus powder 60 of American Ginseng 180.
Further, described health food is capsule form.
A kind of preparation method of the health food with function of physical fatigue alleviation as described above, comprises the following steps：
1）The fruit of Chinese wolfberry, ganoderma lucidum, gynostemma pentaphylla, American Ginseng, cervus elaphus linnaeus powder are standby through after the assay was approved；
2）It is standby after sterilizing by measuring cervus elaphus linnaeus powder；
3）American Ginseng partial amount is taken, crushed after being dried, 100 mesh sieves is crossed, collects fine powder, it is standby after sterilizing；
4）Gynostemma pentaphylla plus 5-10 times are measured into 75% alcohol reflux to extract 2-4 times, each 1.5-3 hours, 200 eye mesh screens of extract solution
Filtration, merging filtrate, the dregs of a decoction are standby, filtrate recycling ethanol, and are concentrated into the medicinal extract that relative density is 1.30~1.35, standby；
5）American Ginseng surplus is extracted 1 time with 95%, 70%, 50%, 30% alcohol reflux respectively, each 5-10 times is measured alcohol reflux
1.5-3 hours, merging extract solution, extract solution is filtered with 200 eye mesh screens, and merging filtrate, the dregs of a decoction are standby, filtrate recycling ethanol, and
The medicinal extract that relative density is 1.30~1.35 is concentrated into, it is standby；
6）The dregs of a decoction are added water to cook 2-3 times after separately taking the fruit of Chinese wolfberry, ganoderma lucidum and gynostemma pentaphylla, American Ginseng alcohol extracting, and every time plus 5-10 times is measured water,
Each to decoct 1.5-3 hours, extract solution is filtered with 200 eye mesh screens, and merging filtrate, the dregs of a decoction discard, and filtrate decompression is concentrated into relatively close
The medicinal extract for 1.30~1.35 is spent, it is standby；
7）Merge above-mentioned 3 kinds of medicinal extract, be dried under reduced pressure, gained dry extract is broken into fine powder, crosses 80 mesh sieves, standby；
8）Above-mentioned dry extract and American Ginseng fine powder, cervus elaphus linnaeus powder are fully mixed, softwood, 16 mesh sieve series are made with 85% ethanol
Grain, 55~60 DEG C of dryings, 14 mesh sieve whole grains, load No. 0 capsule, polish, examine, packaging, get product.
Further, described sterilizing is using 5kGy dosage60Co irradiation sterilizations.
In above-mentioned raw materials, the fruit of Chinese wolfberry, ganoderma lucidum, gynostemma pentaphylla, American Ginseng, cervus elaphus linnaeus powder are marketable material.
The present invention combines traditional Chinese and western medicine theory according to the market demand, and having developed has nourishing liver and kidney, supplementing qi and nourishing yin
The capsule class health food of effect, help to alleviate physical fatigue, so as to improve the health status of fatiguability crowd.
Wherein, the fruit of Chinese wolfberry, it is the dry mature fruit of plant of Solanaceae lycium barbarum.It is sweet, it is mild-natured, return liver and kidney channel.There is taste
Filling liver kidney, the effect of benefiting shrewd head.For diseases such as consumption consumptive loss, soreness of waist and knee joint, blood deficiency chlorosis.The chemical composition of the fruit of Chinese wolfberry is main
Contain LBP-X, glycine betaine, carotenoid and carotenoid ester, vitamin C, scopoletin, several amino acids and trace element
Deng composition.Modern pharmacological research shows, when Fructus lycii P.E can be obviously prolonged the mouse survival time and continue, power exhausts swimming
Between, so as to show that the fruit of Chinese wolfberry can effectively improve the hypoxia-bearing capability and anti-fatigue ability of mouse.Research finds fruit of Chinese wolfberry water decoction
There is obvious antifatigue effect to mouse.Found by zoopery, fruit of Chinese wolfberry decocting liquid energy extends small white mouse at room temperature
Swimming time, improve anti-fatigue ability, illustrate that the fruit of Chinese wolfberry can eliminate exercise induced fatigue, can also build up health.Observe Ningxia Chinese holly
Influence of the matrimony vine to small white mouse locomitivity, as a result shows, deposits mouse swimming time and resist oxygen lack after taking lycium barbarum
Live time significantly extends, and illustrates that lycium barbarum has the function that antifatigue, raising exercise tolerance and hypoxia-bearing capability.Through experiment
Prove, the fruit of Chinese wolfberry can significantly improve mouse liver glycogen content, extend the mice burden swimming time, prompt the fruit of Chinese wolfberry to have antifatigue
Effect.Also there are some researches show the fruit of Chinese wolfberry can significantly improve the hypoxia-bearing capability and anti-fatigue ability of mouse, strengthen endurance.Pass through
Literature review analysis shows, the principle active component LBP-X in the fruit of Chinese wolfberry have obvious antifatigue effect.
Ganoderma lucidum, it is the drying fructification of On Polyporaceae red sesame.It is sweet, it is mild-natured.The thoughts of returning home, lung, liver and kidney channel.With benefit
Gas is calmed the nerves, relieving cough and asthma effect.A kind of ganoderma lucidum history long for clinic as rare Chinese medicine, ganoderma lucidum " invigorating heart gas ",
" pacifying smart soul ", " tonifying liver QI invigorating ", " hard muscles and bones ", " strengthening by means of tonics ", " promoting longevity ", long term usage make one " good color " etc..Ganoderma lucidum
Main active is GL-B, ganoderic acid, adenosine etc..Found by zoopery, glossy ganoderma powder can be obviously prolonged mouse and climb
Bar time and swimming time, hence it is evident that the content of hepatic glycogen content, reduction urea nitrogen and blood lactase acid after rise mouse movement, explanation
Glossy ganoderma powder has antifatigue effect.There is result of study to show, compound ganoderma preparation can be obviously prolonged the walking weight load of mouse,
Raise the hepatic glycogen content of mouse, reduce Serum lactic acid content, it was demonstrated that compound ganoderma preparation has the function that antifatigue.Research hair
Existing, ganoderma lucidum can significantly extend the walking weight load of mouse, have antifatigue effect；And to take ganoderma lucidum liquid energy obvious by sportsman
Improve body fatigue resistance.The antifatigue effect of ganoderma tea is have studied, it is found that ganoderma tea can significantly extend the mouse pole-climbing time,
And substantially reduce mouse urea nitrogen content.There is experiment to show that ganoderma tea can significantly extend the mice burden swimming time, illustrate ganoderma lucidum
Tea has the function that antifatigue.There are some researches show Ganoderma Mixture can significantly improve the hypoxia-bearing capability under mouse normal pressure, and
High dose Ganoderma Mixture can be obviously prolonged the mice burden swimming time, and more obvious with dosage increase, and its effect is better than
American Ginseng and inderal, Systemic stress response ability, resist oxygen lack and antifatigue effect are improved so as to illustrate that Ganoderma Mixture has.
Gynostemma pentaphylla, it is the drying herb of cucurbitaceous plant gynostemma pentaphylla.It is bitter, micro-sweet, cold in nature, return lung, spleen, kidney channel, have
Clearing heat and detoxicating, cough-relieving apophlegmatic, supplementing qi and nourishing yin, vexed for chest diaphragm ruffian the effect of anti-aging, phlegm resistance blood stasis, palpitation, dizziness
Headache, forgetful tinnitus, unconsciously sweat and tire, hyperlipemia, simple obesity, old age cough.Modern pharmacology research shows, gynostemma pentaphylla
4 kinds of saponin(es in saponin are identical with the structure of ginsenoside Rb1, Rb3 Rd and F2 respectively, wherein ginsenoside
Content is 8 times of ginseng, and total saponin content is 3 times of ginseng.Gypenoside is similar to ginsenoside effect, and without excess
The side effect taken.Meanwhile gypenoside has antitumor, anti-mutation, enhancing immunity of organisms, anti-aging, to brain
Cortical neuron damage has antagonism, can strengthen physical efficiency, antifatigue, give full play to the locomitivity of body.Using text
The methods of offering data, experiment, mathematical statistics and logic analysis, by SD male rat gastric infusion gynostemma pentaphylla, and carry out power
Exhausting property swimming test etc. is studied, it is found that gynostemma pentaphylla has the function that to delay to the fatigue of body, enhanced the locomitivity of body,
The exercise tolerance of rat can be strengthened, and reduce the lactic component content after rat motor, so as to improve rat in high intensity exercise
When adaptability, gynostemma pentaphylla can significantly increase mouse blood content of hemoglobin so as to strengthen the O_2 transport ability of body,
Aerobic metabolism is normally carried out during being advantageous to big intensity endurance training, improves aerobic sport ability；Mouse can be significantly decreased
Serum BUN contents, the metabolic capability of other energy substances in Mice Body is improved, reduce the decomposition energy supply ratio of protein, keep
Muscular strength；SOD activity in murine liver tissue can be significantly improved, reduces MDA（MDA）Concentration, there is obvious anti-oxidation function, can
The lipid peroxidation of cell membrane is prevented, effectively protects the liver function of mouse, and then improves locomitivity, delayed motion fatigue
Generation.To inquire into influence of the Herb Gynostemmae Pentaphylli extract to mouse anti-reflecting fatigue ability, by 60 SD mouse be randomly divided into control group and
Medication group, after swimming instruction 6 weeks, measure rest state, power exhaust after at once, power exhaust the phosphorus of rear 24 recovery group mice serum
Creatine acid（CK）, lactic dehydrogenase（LDH）With the index such as flesh, hepatic glycogen.As a result show, gynostemma pentaphylla group serum CK, LDH are significantly low
In control group（P<0.05）, and hepatic glycogen（LG）, muscle glycogen（MG）Content is significantly higher than control group（P<0.05）.Prove gynostemma pentaphylla
Extract may have protective effect to the normal configuration and function of skeletal muscle and liver plasma membrane, can substantially increase hepatic glycogen and flesh
The content of glycogen, be advantageous to delay the generation of mouse movement fatigue.Using mouse anti-reflecting fatigue swimming test, gynostemma pentaphylla pair is observed
The influence of mouse swimming time.Experiment display, gynostemma pentaphylla can increase mouse and swim in the water the time, small dose group and heavy dose of group
Compare with blank control group, there is significant difference（P<0.05）, show that gynostemma pentaphylla has obvious antifatigue effect.Pass through foundation
Swimming instruction model, test the swimming time and hemoglobin of mouse（Hb）, urea nitrogen（BUN）, hepatic tissue superoxides
Mutase（SOD）, MDA（MDA）Etc. index, the antifatigue effect of the wild gynostemma pentaphylla in Hainan have studied.6 weeks gavage gynostemma pentaphylla
After extract solution, mouse swimming time significantly extends, hemoglobin（Hb）And liver superoxide dismutase（SOD）Significantly
Property rise, and blood urea nitrogen（BUN）And hepatic tissue MDA（MDA）Content conspicuousness declines.It is significant to illustrate that gynostemma pentaphylla has
Antifatigue effect, it is possible to increase the locomitivity of mouse.Gavage processing is carried out to ICR mouse with gynostemma pentaphylla complex liquid, it is continuous to fill
Walking weight load and hepatic glycogen, the serum urea nitrogen and Serum lactic acid content of mouse are determined after stomach 30d.As a result show, gynostemma pentaphylla
Complex liquid middle dose group（5.0ml/kg）The walking weight load of mouse can significantly be extended, reduce Serum lactic acid content and blood after motion
Lactic acid TG-AUC；High dose group（15.0ml/kg）Serum urea nitrogen content and blood lactase acid after mouse movement can be significantly reduced
TG-AUC, illustrate that the anti-sports fatigue ability of mouse can be improved by twisting blue complex liquid.Found through pharmacological evaluation, Granular Gulanshen
Mouse successive administration 7 days, pole-climbing and swimming time the difference highly significant compared with control group（P<0.01）, show Granular Gulanshen
Mouse anti-reflecting fatigue ability can be dramatically increased.With reference to training, with regard to gynosaponin（GPs）The antifatigue effect of human body is carried out
Research.Experiment shows gynosaponin（GPs）The following aspects can be shown to the antifatigue effect of human body:（1）Reduce
Lactic acid is accumulated after motion；（2）Improve the ability of phosphate transport protein energy supply；（3）Prevent the low testosterone of motility/high cortisol；（4）Promote
Enter immunologic function, improve the resistance of body.Gynostemma pentaphylla can strengthen sportsman's constitution and improve locomitivity during exercise, prolong
Delay the generation of fatigue, accelerate the elimination of fatigue, forbidden amphetamine and toxic side effect are free of again, by the extensive weight of sports medical science circle
Depending on.
American Ginseng, it is the dry root of Araliaceae American Ginseng.Sweet, slight bitter, cool in nature, the thoughts of returning home, lung, kidney channel.With benefit
Gas yin-nourishing, the effect of clearing heat and promoting fluid.It is mainly used in deficiency of vital energy yin deficiency, abnormal heat is tired of the tired disease that Dengs.It is small that research finds that American ginseng buccal tablet can extend
Mouse walking weight load, and blood lactase acid amount, hepatic glycogen consumption, serum urea nitrogen have compared with control group after mouse movement
Significantly reduce, illustrate that American Ginseng is remarkably reinforced exercise tolerance and relieving fatigue.Shown by zoopery, American Ginseng
Preparation can be obviously prolonged mice burden swimming time, pole-climbing time, and can substantially reduce the serum urea nitrogen after mouse movement and
The content of blood lactase acid, and difference has conspicuousness, it was demonstrated that American Ginseng preparation has antifatigue effect.There is studies have shown that American Ginseng
Oral liquid energy is obviously prolonged the mice burden swimming time, and reduces serum urea nitrogen content caused by motion, hepatic glycogen
Content increase, motion terminate the elimination value increase of blood lactase acid after quiet 20min, and mouse weight is increased without influence, it was demonstrated that west
American ginseng oral liquid has the function that to alleviate mouse physical fatigue.American ginseng buccal tablet can be obviously prolonged as a kind of health food
The mice burden swimming time, serum urea nitrogen level when reducing motion, the consumption of liver glycogen is reduced, reduces high dose after motion
The content of group lactic acid, reaches antifatigue purpose（Liu Shaojuan etc., 2000）.Daily orally administration mouse Granulae Radix Panacis Quinquefolii, the West
Join ball, Oral Liquid Radix Panacis Quinquefolii, after continuous 30 days, Loaned swimming test is carried out to mouse, the lactic acid of mouse, liver after detection motion
Glycogen, urea nitrogen index.Experimental result shows that the various dose of various preparations can extend the mice burden swimming time, middle and high
Relatively there were significant differences with control group for dosage group.Meanwhile caused lactic acid content, hepatic glycogen consumption, blood after mouse movement
Clear urea nitrogen significantly reduces compared with control group.Prove that American Ginseng difference preparation has different degrees of antifatigue effect.
Found by animal experiment study, three dosage groups of American Ginseng piece can significantly improve the storage level of mouse hepatic glycogen, reduce
Blood lactase acid TG-AUC after mouse swimming, reduces serum urea nitrogen content after motion, the clearance rate of urea nitrogen in acceleration bodies,
The swimming time of mouse is improved, shows that American Ginseng piece has antifatigue effect.The patient for suffering from chronic fatigue syndrome by 30
Two groups of control group and experimental group are randomly divided into, experimental group combines the progress of American Ginseng medicine materical crude slice on the basis of routine medication is taken
Treatment, the improvement situation of analysis two groups of patient fatigue's symptoms of contrast.As a result show, the improvement of experimental group fatigue patient clinical symptom
Situation is significantly better than control group, and quick, efficient height, significant difference, P ＜ 0.05.Prove that American Ginseng medicine materical crude slice is that more have
The medicine of the fatigue-relieving of effect, it is rapid-action, and have no side effect, there is the advantages of conventional medicament institute is incomparable.
Cervus elaphus linnaeus powder is the young horn of the unossified dense fine hair of stag of animal in deer family red deer through crushing the fine powder formed.Property
It is sweet, salty, temperature.Return kidney, Liver Channel.《Compendium of Materia Medica》Load is said：" pilose antler production of sperm mends marrow, blood-nourishing Yiyang, strong muscles and bones are a kind of valuable
Chinese medicine, it is effective in cure to weakness, neurasthenia etc. as tonic invigorator.Found by animal experiment study, pilose antler water extract energy
It is obviously prolonged the mice burden swimming time（P ＜ 0.05, p ＜ 0.01）；Reduce mouse blood lactase acid（P ＜ 0.01）And serum urea nitrogen
（P ＜ 0.01）Content；Improve hepatic glycogen in Mice Body（P ＜ 0.05, p ＜ 0.01）And muscle glycogen（P ＜ 0.01）Storage level
And motion after lactic dehydrogenase vigor（P ＜ 0.05, p ＜ 0.01）.It is significantly anti-tired to prove that pilose antler water extract has to mouse
Work is used.Mouse is divided into hydrogenation can mice with kidney-yang deficiency model group and the basic, normal, high dosage group of antler health-care drink caused by pine.Often
Its gavage physiological saline and antler health-care drink 1 time, continuous 28d.Experiment finds that compared with model group, antler health-care drink is each
The body weight of dosage group mouse substantially increases（P ＜ 0.05）；Mouse testis, Testiculo- epididymis, the index of seminal fluid capsule-prostate are obvious
Increase（P ＜ 0.05）；Walking weight load is obviously prolonged（P ＜ 0.05）；It is nitric oxide production in serum and nephridial tissue after motion to contain
Measure significantly raised（P ＜ 0.05）.Show that the antler health-care drink has and promote sexual gland, the growth of accessory sex gland and kidney tonifying functions, together
When there is obvious anti-fatigue effect.There is influence of the Germicidal efficacy antler polypeptide to mouse resist oxygen lack and anti-fatigue ability.Knot
Fruit shows that antler polypeptide can dramatically increase mouse normobaric hypoxia time-to-live, broken end breathing time, pole-climbing time and swimming with a load attached to the body
Time；And the incrementss of serum lactic after swimming can be significantly reduced.Illustrate that antler polypeptide can improve mouse resist oxygen lack and resist tired
The ability of labor.Hairy antler capsules can be obviously prolonged the time-to-live under mouse normobaric hypoxia, extend mouse swimming time, increase mouse
Hepatic tissue RNA and protein content, show that hairy antler capsules have certain resist oxygen lack and antifatigue effect.Sent out by zoopery
Existing, the mice burden swimming test of antler health-care drink, blood lactase acid, urea nitrogen, hepatic glycogen are all positive result, show that pilose antler is protected
Strong drink has the function that antifatigue.
In summary, this product is from traditional Chinese medicine traditional theory, and combines modern pharmacological research, using Chinese herbal medicine as original
Material, the mechanism according to caused by fatigue, prescription is carried out from the fruit of Chinese wolfberry, ganoderma lucidum, gynostemma pentaphylla, American Ginseng, cervus elaphus linnaeus powder, passes through nourishing
Liver kidney, supplementing qi and nourishing yin adjust human body physiological state, so as to reach the purpose for alleviating physical fatigue.The fruit of Chinese wolfberry in inventive formulation
Nourishing liver and kidney, benefiting essence-blood；Ganoderma lucidum invigorating heart gas, An Jinghun, hard muscles and bones；Gynostemma pentaphylla supplementing qi and nourishing yin；American Ginseng boosting qi and nourishing yin, heat-clearing life
Tianjin；Cervus elaphus linnaeus production of sperm mends marrow, blood-nourishing Yiyang, strong muscles and bones.All mutual compatibilities of medicine phases, mutually make complementation, play nourishing liver and kidney, QI invigorating altogether and support
The effect of cloudy, so as to reach the purpose for alleviating physical fatigue.Property of the invention according to ingredients active ingredient, extracted,
The techniques such as concentration are process, and both ensure that the abundant extraction of effective component, have been decreased the dose of medicine.This product simultaneously
Using capsule, the poor taste of Chinese medicine was not only masked but also had been easy to carry, and can preferably be esthetically acceptable to the consumers.Tried by toxicology
Test, animal function test proves that this product is safe and effective, can be eaten for a long time.
Brief description of the drawings
Fig. 1 is the flow chart of preparation method of the present invention.
Embodiment
With reference to embodiment, the present invention is described in more detail.But skilled in the art realises that following embodiments
It is not limiting the scope of the invention, any improvement and change made on the basis of the present invention, all guarantor in the present invention
Within the scope of shield.
Embodiment 1
1）The parts by weight of the fruit of Chinese wolfberry 480, the parts by weight of ganoderma lucidum 450, the parts by weight of gynostemma pentaphylla 400, the parts by weight of American Ginseng 220, cervus elaphus linnaeus powder
100 parts by weight, gomi herbs, used after the assay was approved for preparation.
2）Formula ratio cervus elaphus linnaeus powder is taken, with 5kGy dosage60It is standby after Co irradiation sterilizations.
3）Take American Ginseng appropriate, dry（60℃）After crush, cross 100 mesh sieves, the parts by weight of fine powder 100 are collected, with 5kGy agent
Amount60It is standby after Co irradiation sterilizations.
4）By the parts by weight of gynostemma pentaphylla 400,8 times of 75% alcohol refluxs of amount are added to extract 3 times, 2 hours every time, 200 mesh of extract solution
Screen cloth filters, merging filtrate（The dregs of a decoction are standby）, filtrate recycling ethanol（- 0.065~-0.075Mpa, 65 DEG C）, and it is concentrated into phase
It is 1.30~1.35 to density（60 DEG C of surveys）Medicinal extract, it is standby.
5）By the parts by weight of American Ginseng 120, extracted 1 time with 95%, 70%, 50%, 30% alcohol reflux respectively, measure second for 8 times every time
Alcohol reflux 2 hours, merge extract solution, extract solution is filtered with 200 eye mesh screens, merging filtrate（The dregs of a decoction are standby）, filtrate recycling ethanol
（- 0.065~-0.075Mpa, 65 DEG C）, and relative density is concentrated into as 1.30~1.35（60 DEG C of surveys）Medicinal extract, it is standby.
6）The dregs of a decoction add water to cook 2 after separately taking the parts by weight of the fruit of Chinese wolfberry 480, the parts by weight of ganoderma lucidum 450 and gynostemma pentaphylla, American Ginseng alcohol extracting
Secondary, every time plus 8 times are measured water, and each to decoct 2 hours, extract solution is filtered with 200 eye mesh screens, merging filtrate（The dregs of a decoction discard）, filtrate subtracts
Pressure concentration（- 0.065~-0.075Mpa, 75 DEG C）It is 1.30~1.35 to relative density（60 DEG C of surveys）Medicinal extract, it is standby.
7）Merge above-mentioned 3 kinds of medicinal extract, be dried under reduced pressure（- 0.085Mpa, 65 DEG C）, gained dry extract is broken into fine powder, crosses 80
Mesh sieve, it is standby.
8）Above-mentioned dry extract and American Ginseng fine powder, cervus elaphus linnaeus powder are fully mixed, softwood, 16 mesh are made with 85% ethanol
Sieve series grain, 55~60 DEG C of dryings, 14 mesh sieve whole grains, load No. 0 capsule, polish, examine, packaging, get product.
Embodiment 2
1）The parts by weight of the fruit of Chinese wolfberry 320, the parts by weight of ganoderma lucidum 300, the parts by weight of gynostemma pentaphylla 280, the parts by weight of American Ginseng 120, cervus elaphus linnaeus powder
20 parts by weight, gomi herbs, used after the assay was approved for preparation.
2）Formula ratio cervus elaphus linnaeus powder is taken, with 5kGy dosage60It is standby after Co irradiation sterilizations.
3）Take American Ginseng appropriate, dry（60℃）After crush, cross 100 mesh sieves, the parts by weight of fine powder 50 are collected, with 5kGy dosage
's60It is standby after Co irradiation sterilizations.
4）By the parts by weight of gynostemma pentaphylla 280,5 times of 75% alcohol refluxs of amount are added to extract 4 times, 3 hours every time, 200 mesh of extract solution
Screen cloth filters, merging filtrate（The dregs of a decoction are standby）, filtrate recycling ethanol（- 0.065~-0.075Mpa, 65 DEG C）, and it is concentrated into phase
It is 1.30~1.35 to density（60 DEG C of surveys）Medicinal extract, it is standby.
5）By the parts by weight of American Ginseng 70, extracted 1 time with 95%, 70%, 50%, 30% alcohol reflux respectively, measure ethanol for 5 times every time
Backflow 3 hours, merge extract solution, extract solution is filtered with 200 eye mesh screens, merging filtrate（The dregs of a decoction are standby）, filtrate recycling ethanol（-
0.065~-0.075Mpa, 65 DEG C）, and relative density is concentrated into as 1.30~1.35（60 DEG C of surveys）Medicinal extract, it is standby.
6）The dregs of a decoction add water to cook 2 after separately taking the parts by weight of the fruit of Chinese wolfberry 320, the parts by weight of ganoderma lucidum 300 and gynostemma pentaphylla, American Ginseng alcohol extracting
Secondary, every time plus 5 times are measured water, and each to decoct 3 hours, extract solution is filtered with 200 eye mesh screens, merging filtrate（The dregs of a decoction discard）, filtrate subtracts
Pressure concentration（- 0.065~-0.075Mpa, 75 DEG C）It is 1.30~1.35 to relative density（60 DEG C of surveys）Medicinal extract, it is standby.
7）Merge above-mentioned 3 kinds of medicinal extract, be dried under reduced pressure（- 0.085Mpa, 65 DEG C）, gained dry extract is broken into fine powder, crosses 80
Mesh sieve, it is standby.
8）Above-mentioned dry extract and American Ginseng fine powder, cervus elaphus linnaeus powder are fully mixed, softwood, 16 mesh are made with 85% ethanol
Sieve series grain, 55~60 DEG C of dryings, 14 mesh sieve whole grains, load No. 0 capsule, polish, examine, packaging, get product.
Embodiment 3
1）The parts by weight of the fruit of Chinese wolfberry 400, the parts by weight of ganoderma lucidum 420, the parts by weight of gynostemma pentaphylla 300, the parts by weight of American Ginseng 150, cervus elaphus linnaeus powder
50 parts by weight, gomi herbs, used after the assay was approved for preparation.
2）Formula ratio cervus elaphus linnaeus powder is taken, with 5kGy dosage60It is standby after Co irradiation sterilizations.
3）Take American Ginseng appropriate, dry（60℃）After crush, cross 100 mesh sieves, the parts by weight of fine powder 60 are collected, with 5kGy dosage
's60It is standby after Co irradiation sterilizations.
4）By the parts by weight of gynostemma pentaphylla 300,6 times of 75% alcohol refluxs of amount are added to extract 2 times, 2 hours every time, 200 mesh of extract solution
Screen cloth filters, merging filtrate（The dregs of a decoction are standby）, filtrate recycling ethanol（- 0.065~-0.075Mpa, 65 DEG C）, and it is concentrated into phase
It is 1.30~1.35 to density（60 DEG C of surveys）Medicinal extract, it is standby.
5）By the parts by weight of American Ginseng 90, extracted 1 time with 95%, 70%, 50%, 30% alcohol reflux respectively, measure ethanol for 6 times every time
Backflow 2 hours, merge extract solution, extract solution is filtered with 200 eye mesh screens, merging filtrate（The dregs of a decoction are standby）, filtrate recycling ethanol（-
0.065~-0.075Mpa, 65 DEG C）, and relative density is concentrated into as 1.30~1.35（60 DEG C of surveys）Medicinal extract, it is standby.
6）The dregs of a decoction add water to cook 2 after separately taking the parts by weight of the fruit of Chinese wolfberry 400, the parts by weight of ganoderma lucidum 420 and gynostemma pentaphylla, American Ginseng alcohol extracting
Secondary, every time plus 6 times are measured water, and each to decoct 2 hours, extract solution is filtered with 200 eye mesh screens, merging filtrate（The dregs of a decoction discard）, filtrate subtracts
Pressure concentration（- 0.065~-0.075Mpa, 75 DEG C）It is 1.30~1.35 to relative density（60 DEG C of surveys）Medicinal extract, it is standby.
7）Merge above-mentioned 3 kinds of medicinal extract, be dried under reduced pressure（- 0.085Mpa, 65 DEG C）, gained dry extract is broken into fine powder, crosses 80
Mesh sieve, it is standby.
8）Above-mentioned dry extract and American Ginseng fine powder, cervus elaphus linnaeus powder are fully mixed, softwood, 16 mesh are made with 85% ethanol
Sieve series grain, 55~60 DEG C of dryings, 14 mesh sieve whole grains, load No. 0 capsule, polish, examine, packaging, get product.
Embodiment 4
1）The parts by weight of the fruit of Chinese wolfberry 420, the parts by weight of ganoderma lucidum 380, the parts by weight of gynostemma pentaphylla 340, the parts by weight of American Ginseng 180, cervus elaphus linnaeus powder
60 parts by weight, gomi herbs, used after the assay was approved for preparation.
2）Formula ratio cervus elaphus linnaeus powder is taken, with 5kGy dosage60It is standby after Co irradiation sterilizations.
3）Take American Ginseng appropriate, dry（60℃）After crush, cross 100 mesh sieves, the parts by weight of fine powder 80 are collected, with 5kGy dosage
's60It is standby after Co irradiation sterilizations.
4）By the parts by weight of gynostemma pentaphylla 340,7 times of 75% alcohol refluxs of amount are added to extract 2 times, 1.5 hours every time, extract solution was with 200
Eye mesh screen filters, merging filtrate（The dregs of a decoction are standby）, filtrate recycling ethanol（- 0.065~-0.075Mpa, 65 DEG C）, and be concentrated into
Relative density is 1.30~1.35（60 DEG C of surveys）Medicinal extract, it is standby.
5）By the parts by weight of American Ginseng 100, extracted 1 time with 95%, 70%, 50%, 30% alcohol reflux respectively, measure second for 8 times every time
Alcohol reflux 1.5 hours, merge extract solution, extract solution is filtered with 200 eye mesh screens, merging filtrate（The dregs of a decoction are standby）, filtrate recovery second
Alcohol（- 0.065~-0.075Mpa, 65 DEG C）, and relative density is concentrated into as 1.30~1.35（60 DEG C of surveys）Medicinal extract, it is standby.
6）The dregs of a decoction add water to cook 2 after separately taking the parts by weight of the fruit of Chinese wolfberry 420, the parts by weight of ganoderma lucidum 380 and gynostemma pentaphylla, American Ginseng alcohol extracting
Secondary, every time plus 8 times are measured water, and each to decoct 1.5 hours, extract solution is filtered with 200 eye mesh screens, merging filtrate（The dregs of a decoction discard）, filtrate
It is concentrated under reduced pressure（- 0.065~-0.075Mpa, 75 DEG C）It is 1.30~1.35 to relative density（60 DEG C of surveys）Medicinal extract, it is standby.
7）Merge above-mentioned 3 kinds of medicinal extract, be dried under reduced pressure（- 0.085Mpa, 65 DEG C）, gained dry extract is broken into fine powder, crosses 80
Mesh sieve, it is standby.
8）Above-mentioned dry extract and American Ginseng fine powder, cervus elaphus linnaeus powder are fully mixed, softwood, 16 mesh are made with 85% ethanol
Sieve series grain, 55~60 DEG C of dryings, 14 mesh sieve whole grains, load No. 0 capsule, polish, examine, packaging, get product.
Test example：
The beneficial effect of given the test agent is expanded on further below by way of test example, these test examples include swimming with a load attached to the body reality
Test, serum urea nitrogen is tested, blood lactase acid is tested, hepatic glycogen content experiment.
Capsule crowd recommends daily intaking amount 2.4g/60kgBW（That is 0.04g/kgBW）, expand 10,20,30 times, set
Basic, normal, high three dosage groups, each group experimental animal number（SPF level Male Kunming strain mices, 18-22g, 160）It is 10.
Test example 1：Influence of the given the test agent to the mice burden swimming time
Method：Mouse continuous gavage 30 days, last 5% body weight of mouse tail root heavy burden, put swimming trunk to 30min after test medicine
Went swimming observation mouse is from swimming to the death time.24-26 DEG C of room temperature, water temperature：25℃±1℃.
Result of the test：
The middle and high dosage group of given the test agent can extend the mice burden swimming time, and compared with negative control group, difference has conspicuousness（P
＜ 0.05, P ＜ 0.01）, it is shown in Table 1.
Influence of the given the test agent of table 1 to the mice burden swimming time
Test example 2：Influence of the given the test agent to mice serum urea nitrogen
Method：Mouse continuous gavage 30 days, last are put into 30 DEG C of water went swimming 90min, water outlet to 30min after test medicine
Afterwards, rest 60min, eyeball take hematometry serum urea nitrogen content.Determination of urea nitrogen is using the type full-automatic biochemical point of Hitachi 7020
Analyzer measure is analysed, kit is provided by Fenghui Medical Science and Technology Co., Ltd., Shanghai, lot number：131141.Room temperature：24-26℃.
Result of the test：
Three dosage of given the test agent（It is basic, normal, high）Group can significantly reduce mice serum uric acid level, compared with negative control group,
Difference has conspicuousness（P ＜ 0.001, P ＜ 0.01, P ＜ 0.001）, it is shown in Table 2.
Influence of the given the test agent of table 2 to mice serum urea nitrogen
Test example 3：Influence of the given the test agent to mouse swimming blood lactase acid value and blood lactase acid TG-AUC
Method：Mouse continuous gavage 30 days, last are put into 30 DEG C of water went swimming 10min, swimming to 30min after test medicine
Before, swimming after at once, swimming rest after 20min take blood three times respectively（Endocanthion takes blood）Blood lactase acid value is determined, is built up using Nanjing
The blood lactase acid kit measurement of bio-engineering corporation's production, kit lot number：20131217.Room temperature：24-26℃.
Result of the test：
Each dosage group of given the test agent can not be reduced below blood lactase acid value and blood lactase acid curve after mouse is swum and after rest
Product, with negative control group comparing difference without conspicuousness（Equal P ＞ 0.05）, it is shown in Table 3,4.
Influence of the given the test agent of table 3 to mouse swimming blood lactase acid value
Influence of the given the test agent of table 4 to mouse blood lactase acid TG-AUC
Test example 4：Influence of the given the test agent to mouse hepatic glycogen content
Method：Mouse continuous gavage 30 days, last take liver to determine hepatic glycogen content to 30min after test medicine.Hepatic glycogen is surveyed
Surely the kit of bio-engineering corporation's production, kit lot number are built up using Nanjing：20131216.Room temperature：24-26℃.
Result of the test：
Given the test agent high dose group can significantly raise mouse hepatic glycogen content, and compared with negative control group, difference has conspicuousness（P
＜ 0.05）, it is shown in Table 5.
Influence of the given the test agent of table 5 to mouse hepatic glycogen content
Conclusion：1）Middle and high dosage group can extend the mice burden swimming time；2）Three dosage（It is basic, normal, high）Group can significantly drop
Low mice serum uric acid level；3）Each dosage group can not reduce the blood lactase acid value and blood lactase acid song after mouse is swum and after rest
Area has no significant effect under line, no significant difference；4）High dose group can significantly raise mouse hepatic glycogen value.
According to function of physical fatigue alleviation evaluation of effect procedure stipulation, comprehensive every result of the test judges, health care of the present invention
Product capsule has function of physical fatigue alleviation.
Claims (7)
1. a kind of health food with function of physical fatigue alleviation, it is made up by weight ratio of following raw materials according：
Fruit of Chinese wolfberry 300-500 ganoderma lucidum 280-480 gynostemma pentaphylla 250-420
American Ginseng 100-250 cervus elaphus linnaeus powder 10-120.
2. a kind of health food with function of physical fatigue alleviation according to claim 1, it is characterised in that described
Health food is made up by weight ratio of following raw materials according：
Fruit of Chinese wolfberry 320-480 ganoderma lucidum 300-450 gynostemma pentaphylla 280-400
American Ginseng 120-220 cervus elaphus linnaeus powder 20-100.
3. a kind of health food with function of physical fatigue alleviation according to claim 1, it is characterised in that described
Health food is made up by weight ratio of following raw materials according：
Fruit of Chinese wolfberry 380-450 ganoderma lucidum 350-420 gynostemma pentaphylla 300-380
American Ginseng 150-200 cervus elaphus linnaeus powder 30-80.
4. a kind of health food with function of physical fatigue alleviation according to claim 1, it is characterised in that described
Health food is made up by weight ratio of following raw materials according：
The gynostemma pentaphylla 340 of 420 ganoderma lucidum of the fruit of Chinese wolfberry 380
The cervus elaphus linnaeus powder 60 of American Ginseng 180.
5. a kind of health food with function of physical fatigue alleviation according to claim 1, it is characterised in that described
Health food is capsule form.
6. a kind of preparation method of the health food with function of physical fatigue alleviation as claimed in claim 1, including following step
Suddenly：
1）The fruit of Chinese wolfberry, ganoderma lucidum, gynostemma pentaphylla, American Ginseng, cervus elaphus linnaeus powder are standby through after the assay was approved；
2）It is standby after sterilizing by measuring cervus elaphus linnaeus powder；
3）American Ginseng partial amount is taken, crushed after being dried, 100 mesh sieves is crossed, collects fine powder, it is standby after sterilizing；
4）Gynostemma pentaphylla plus 5-10 times are measured into 75% alcohol reflux to extract 2-4 times, each 1.5-3 hours, 200 eye mesh screens of extract solution
Filtration, merging filtrate, the dregs of a decoction are standby, filtrate recycling ethanol, and are concentrated into the medicinal extract that relative density is 1.30~1.35, standby；
5）American Ginseng surplus is extracted 1 time with 95%, 70%, 50%, 30% alcohol reflux respectively, each 5-10 times is measured alcohol reflux
1.5-3 hours, merging extract solution, extract solution is filtered with 200 eye mesh screens, and merging filtrate, the dregs of a decoction are standby, filtrate recycling ethanol, and
The medicinal extract that relative density is 1.30~1.35 is concentrated into, it is standby；
6）The dregs of a decoction are added water to cook 2-3 times after separately taking the fruit of Chinese wolfberry, ganoderma lucidum and gynostemma pentaphylla, American Ginseng alcohol extracting, and every time plus 5-10 times is measured water,
Each to decoct 1.5-3 hours, extract solution is filtered with 200 eye mesh screens, and merging filtrate, the dregs of a decoction discard, and filtrate decompression is concentrated into relatively close
The medicinal extract for 1.30~1.35 is spent, it is standby；
7）Merge above-mentioned 3 kinds of medicinal extract, be dried under reduced pressure, gained dry extract is broken into fine powder, crosses 80 mesh sieves, standby；
8）Above-mentioned dry extract and American Ginseng fine powder, cervus elaphus linnaeus powder are fully mixed, softwood, 16 mesh sieve series are made with 85% ethanol
Grain, 55~60 DEG C of dryings, 14 mesh sieve whole grains, load No. 0 capsule, polish, examine, packaging, get product.
7. a kind of preparation method of health food with function of physical fatigue alleviation according to claim 6, its feature
It is described sterilizing using 5kGy dosage60Co irradiation sterilizations.
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| CN110771894A (en) * | 2019-12-13 | 2020-02-11 | 内蒙古中鹿科技有限责任公司 | Pilose antler oral liquid and preparation method thereof |
| CN112137106A (en) * | 2020-09-22 | 2020-12-29 | 绿之韵生物工程集团有限公司 | Health food with anti-fatigue effect and preparation method thereof |
| CN116035204A (en) * | 2022-12-20 | 2023-05-02 | 大连康芝源生物科技有限公司 | Edible fungus extract fermentation type energy supplementing food and preparation method thereof |
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Application publication date: 20171222 |