CN1318316A - Immunity-regulating and fatigue-resisting health food - Google Patents
Immunity-regulating and fatigue-resisting health food Download PDFInfo
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- CN1318316A CN1318316A CN01112974A CN01112974A CN1318316A CN 1318316 A CN1318316 A CN 1318316A CN 01112974 A CN01112974 A CN 01112974A CN 01112974 A CN01112974 A CN 01112974A CN 1318316 A CN1318316 A CN 1318316A
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Abstract
The health food of the present invention is produced by utilizing chitosan in different molecular weight as main material and compounding with glossy ganoderma fine powder, wall-breaking glossy ganoderma spore powder, Lycium chinese, Coix seed, tackahoe, gynostemma pentaphylla extraction, amino glucose hydrochloride and other components to produce powder and capsule. Animal experiment provides the presnet invention, has determined functions of regulating immunity, resisting fatigue and assisting inhibiting tumor.
Description
The invention belongs to the health-oriented products field, be specifically related to dual-purpose raw-material immunity-regulating of a kind of pastille thing and antifatigue health food.
Chitosan be by chitin be β-(1-4) poly--2-acetylaminohydroxyphenylarsonic acid D-glucose is through deacetylated and make; be the copolymer that contains β-(1-4)-2-acetylaminohydroxyphenylarsonic acid D-glucose unit and β-(1-4)-2-amino-D-glucose unit, the latter generally surpasses 85%.Chitosan (also claiming chitosan, aminoglycan) characterizes with its deacetylation and mean molecule quantity.Its dissolubility in water is greater than chitin.Having amino in the chitosan molecule structure, is the unique positively charged dietary fiber of finding at present of occurring in nature, has good affinity and intermiscibility with human body, has obtained being familiar with widely and paying attention in field of medicaments.
The purpose of this invention is to provide a kind of the have definite immunoloregulation function and the health food of antifatigue effect, the present invention is a primary raw material with the different molecular weight chitosan, is equipped with other supplements and makes dosage forms such as powder and capsule, and how peaceful its commodity blueness by name is.The present invention can be used for hypoimmunity, fatiguability and causes easily suffering from the specific crowd of various diseases because of hypoimmunity.
The present invention adopts the principle of traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors, with different molecular weight≤0.6 ten thousand, 0.6～5 ten thousand and 5～300,000 chitosan is mixed in proportion, and is equipped with the smart powder of natural medicine-food dual-use materials Ganoderma, Ganoderma spore powder with cellular wall broken, Fructus Lycii, Semen Coicis, Poria, Herb Gynostemmae Pentaphylli extract and glucosamine hydrochloride etc. simultaneously compositions are refining to form.Wherein the different molecular weight chitosan has different effectiveness, is intended to improve body immunity; Be equipped with the smart powder of Ganoderma, Ganoderma spore powder with cellular wall broken, Semen Coicis, Poria etc. and can strengthen the effect of regulating immunity.Fructus Lycii wherein, Herb Gynostemmae Pentaphylli extract can be brought into play the effect of resisting fatigue.Above-mentioned all product share, and by cellular immunization, humoral immunization, specific immunity and four kinds of approach of nonspecific immunity, improve body immunity comprehensively.Comprehensive simultaneously human body ecological balance both microecological balance, body fluid acid-base balance, the interior anion cation balance of body, the neuroendocrine-immune system balance adjusted plays immunomodulating, antifatigue effect jointly.
Natural medicine-food dual-use materials of the present invention is commercially available, wherein:
Ganoderma is the sporophore of Polyporaceae fungus Ganoderma, Ganoderma etc.Sweet in the mouth, light, property is flat.GUIXIN, lung, spleen channel.Ganoderan is one of main effective ingredient of Ganoderma, has effects such as immunomodulating.Ganoderma can increase the phagocytic function of macrophage; Can significantly promote the inductive normal mouse antibody forming cell reaction of sheep red blood cell (SRBC) (SRBC), show the humoral immunization effect that can promote normal body; The Ganoderma lucidum (Leyss. Ex Fr.) Karst. polysaccharide can promote the synthetic and secretion IL-1 of macrophage.
Ganoderma spore: the macromolecule polysaccharide in the Ganoderma spore can improve immune function of human body (its action effect approximately is 80 times of Ganoderma sporophore), can improve immunoglobulin and complement content rapidly, directly stimulate lymphopoiesis, strengthen the resistance of human body, improve body immunity disease.
Fructus Lycii: be the fruit of plant of Solanaceae lycium barbarum.Sweet in the mouth, property is flat.Return liver, kidney, lung meridian.Lycium barbarum polysaccharide can significantly improve the T lymhocyte transformation rate, increases peripheral blood leucocyte sum and neutrophil cell, strengthens specific immunity, promotes cellular immunization and humoral immunization.
Lycium barbarum polysaccharide can be removed mobility's skeletal muscle fatigue, has the effect of resisting fatigue.
Semen Coicis: be the kernel of grass Semen Coicis.Sweet in the mouth, light, cold nature.Return spleen, stomach, lung meridian.Its composition glucosan and acidic polysaccharose CA-1, CA-2 show anticomplementary activity, can make macrophage produce the justacrine il-1, and the effect that strengthens humoral immunization is arranged.
Poria: be the sclerotium of Polyporaceae fungus Poria.Sweet in the mouth, light, property is flat.GUIXIN, spleen, lung, kidney channel.Still not a kind of immunostimulant preferably of pachyman can promote cellular immune function, and can protect immune organ targetedly, thereby improve body condition, increases anti-infection ability.
Herb Gynostemmae Pentaphylli extract: gypenoside be a kind of have to the ginsenoside act on similar immunostimulant, can improve the T lymphocyte number, strengthen the activity of natural killer cell (NK), improve the phagocytic function of macrophage.Herb Gynostemmae Pentaphylli total glycosides can prolong mice and continue nearly 1 times of swimming time, has significant antifatigue effect.
Each set of dispense of health food of the present invention is such as descending (consumption is a weight portion):
Low-molecular weight chitoglycan (molecular weight≤6000,6000～50,000 and 5～300,000), account for the 10-60% of total component, the smart powder of Ganoderma accounts for the 1-10% of total component, and Ganoderma spore powder with cellular wall broken accounts for the 1-8% of total component, and Semen Coicis accounts for the 1-8% of total component, Poria accounts for the 1-8% of total component, Fructus Lycii extract accounts for the 1-10% of total component, and Herb Gynostemmae Pentaphylli extract accounts for the 1-10% of total component, and glucosamine hydrochloride accounts for the 0.5-5% of total component.
Health food preparation method of the present invention is that after will pulverizing according to a conventional method respectively by the smart powder of the chitosan Ganoderma of different molecular weight proportioning, Ganoderma spore powder with cellular wall broken, Semen Coicis, Poria etc., capsule is granulated, recorded to mixing, drying at last.
Concrete steps are as follows:
1, with chitosan, the smart powder vacuum drying of Ganoderma,
2, get 75% alcoholic solution such as Poria, Semen Coicis, Fructus Lycii, Ganoderma spore powder and soak into sterilization after, vacuum drying
3, by the component proportioning Poria, Semen Coicis, Fructus Lycii are mixed and be ground into 100 order left and right sides fine powders in the rearmounted pulverizer.
4, spore powder superfine disruption (sporoderm-broken rate is more than 90%).
5, take by weighing chitosan, the smart powder of Ganoderma, above-mentioned Chinese medicinal powder and other compositions by the component proportioning and put abundant mixing in the mixer, granulate.
6, use the capsule filler filling in the 0# capsule granule, every 0.4g, content uniformity inspection.
Instructions of taking is every day 3 times, each 3-4 grain.
For confirming effect of the present invention, the present invention has carried out relevant immunoloregulation function and anti-fatigue test to Kunming mouse.
Table 1 influences Kunming kind male white mouse NK cytoactive for the present invention
*(through variance analysis) compared in p＜0.05 with matched group
| Group | Number of animals (only) | Time (my god) | The NK cytoactive |
| Dosage high dose in the contrast low dosage | ??10 ??10 ??10 ??10 | ???28 ???28 ???28 ???28 | ???41±2.3 ???44±2.8 ???46±6.0 ???61±7.7* |
Table 2 is tested Kunming kind male white mouse macrophage phagocytic for the present invention
*(through variance analysis) compared in p＜0.05 with matched group
| Group | Number of animals (only) | Engulf % | Phagocytic index |
| Dosage high dose in the contrast low dosage | ????10 ????10 ????10 ????10 | ????41±3.1 ????44±3.1 ????47±2.9 ????57±4.9* | ????0.51±0.03 ????0.54±0.04 ????0.58±0.04 ????0.74±0.06* |
Table 3 is the shadow of the present invention to Kunming kind male white mouse motion back hepatic glycogen
*(through variance analysis) compared in p＜0.05 with matched group
| Group | Number of animals (only) | Hepatic glycogen (mg/100g) |
| Dosage high dose in the contrast low dosage | ????10 ????10 ????10 ????10 | ????387±32 ????400±86 ????482±76 ????825±251* |
Table 4 is tested Kunming kind male white mouse S180 tumor suppression for the present invention
| Group | Number of animals (only) | Heavy (g) (for the first time) of tumor | Suppression ratio (%) | Heavy (g) (for the second time) of tumor | Suppression ratio (%) |
| Dosage high dose in the contrast low dosage | ???10 ???10 ???10 ???10 | ????1.44±0.36 ????1.31±0.28 ????1.12±0.37 ????0.88±0.22 | ?????- ????9.0 ???27.2 ???38.9 | ????1.53±0.39 ????1.33±0.43 ????1.21±0.42 ????0.94±0.67* | ????- ????13.1 ????23.9 ????38.6 |
*(through variance analysis) compared in p＜0.05 with matched group
Result's proof has following definite physiological function and characteristics:
The invention belongs to nontoxic level material, what can increase the animal macrophage engulfs % and phagocytic index, improves NK cytoactive, antibody product and cellular immune level; Can prolong the animal swimming with a load attached to the body time, increase the elimination amplitude of animal movement bleeding from anus lactic acid, reduce urea nitrogen levels, promote the hepatic glycogen deposit.Conclusion has immunomodulating merit and antifatigue effect and auxiliary function of tumor inhibition for health food of the present invention.
Embodiment one
Getting each component contains by powder in per 100 gram capsules
Chitosan [molecular weight≤6000 (20%), 6000～50,000 (30%), 5～300,000 (50%) 75000mg
The smart powder 5000mg of Ganoderma Semen Coicis 3750mg
Ganoderma spore powder with cellular wall broken 3750mg Fructus Lycii 3750mg
Starch 750mg Poria 3750mg
Herb Gynostemmae Pentaphylli extract 3000mg glucosamine hydrochloride 1250mg
Above-mentioned each component is refining by preparation method requirement mixing, record into capsule and promptly get this health-care edible capsule.
Embodiment two
Getting each component contains by powder in per 100 gram capsules
Chitosan [molecular weight≤6000 (30%) 3～50,000 (30%) 10～30 (40%)] 42000mg
The smart powder 10000mg of Ganoderma Semen Coicis 8000mg
Ganoderma spore powder with cellular wall broken 8000mg Fructus Lycii 8000mg
Starch 1000mg Poria 8000mg
Herb Gynostemmae Pentaphylli extract 10000mg glucosamine hydrochloride 5000mg
Above-mentioned each component by the preparation method requirement, is mixed and made with extra care, record into capsule and promptly get the present invention.
Claims (5)
1, a kind of immunity-regulating and antifatigue health food, it is characterized in that it is to be made by the following weight proportion raw material: different molecular weight chitosan (molecular weight≤6000,6000～50,000 and 5～300,000) account for the 10-60% of total component, the smart powder of Ganoderma accounts for the 1-10% of total component, Ganoderma spore powder with cellular wall broken accounts for the 1-8% of total component, Semen Coicis accounts for the 1-8% of total component, Poria accounts for the 1-8% of total component, Fructus Lycii extract accounts for the 1-10% of total component, Herb Gynostemmae Pentaphylli extract accounts for the 1--10% of total component, and glucosamine hydrochloride accounts for the 0.5-5% of total component.
2,, it is characterized in that containing in described per 100 gram health foods by the described health food of claim 1
Different molecular weight chitosan 75g
The smart powder 5g of Ganoderma Semen Coicis 3.750g
Ganoderma spore powder with cellular wall broken 3.750g Fructus Lycii 3.750g
Starch 0.75g Poria 3.750g
Herb Gynostemmae Pentaphylli extract 3g glucosamine hydrochloride 1.250g
Above-mentioned each component is refining by preparation method requirement mixing, record into capsule and promptly get this health-care edible capsule.
3, by the described health food of claim 2, it is characterized in that described different molecular weight chitosan, contain molecular weight≤6000 be 20%, 6000～50,000 be 30%, 5～300,000 be 50%.
4,, it is characterized in that containing in described per 100 gram health foods by the described health food of claim 1
Different molecular weight chitosan 42g
The smart powder 10g of Ganoderma Semen Coicis 8g
Ganoderma spore powder with cellular wall broken 8g Fructus Lycii 8g
Starch 1g Poria 8g
Herb Gynostemmae Pentaphylli extract 10g glucosamine hydrochloride 5g
5, by the described health food of claim 4, it is characterized in that described different molecular weight chitosan contains molecular weight 6000 be 30%, 3～50,000 be 30%, 10～300,000 be 40%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011129743A CN1232184C (en) | 2001-05-24 | 2001-05-24 | Immunity-regulating and fatigue-resisting health food |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011129743A CN1232184C (en) | 2001-05-24 | 2001-05-24 | Immunity-regulating and fatigue-resisting health food |
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| CN1318316A true CN1318316A (en) | 2001-10-24 |
| CN1232184C CN1232184C (en) | 2005-12-21 |
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| CNB011129743A Expired - Fee Related CN1232184C (en) | 2001-05-24 | 2001-05-24 | Immunity-regulating and fatigue-resisting health food |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100352373C (en) * | 2005-12-07 | 2007-12-05 | 谯凤华 | Health-care food Lingchong crusta-amine for improving user's immunity and its prepn. method |
| CN102960731A (en) * | 2012-12-19 | 2013-03-13 | 杭州滢宝生物科技有限公司 | Method for preparing antioxidative reishi shell-broken spore powder and product |
| CN103478536A (en) * | 2013-08-13 | 2014-01-01 | 当涂县瑞龙果树种植专业合作社 | Anti-fatigue of purple sweet potato glutinous rice flour and preparation method thereof |
| CN103690574A (en) * | 2013-12-25 | 2014-04-02 | 南京中科药业有限公司 | Poria-containing traditional Chinese medicine combination for enhancing immunity and preparation method of poria-containing traditional Chinese medicine combination |
| CN104997022A (en) * | 2015-06-19 | 2015-10-28 | 青岛浩大海洋保健食品有限公司 | Marine health care capsule having efficacy of immunoregulation |
| CN107495350A (en) * | 2017-10-13 | 2017-12-22 | 延边韩工坊健康制品有限公司 | A kind of health food and preparation method with function of physical fatigue alleviation |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455371B (en) * | 2008-11-27 | 2012-10-03 | 成都润馨堂药业有限公司 | Health-care product containing buckwheat flavone and preparation method thereof |
-
2001
- 2001-05-24 CN CNB011129743A patent/CN1232184C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100352373C (en) * | 2005-12-07 | 2007-12-05 | 谯凤华 | Health-care food Lingchong crusta-amine for improving user's immunity and its prepn. method |
| CN102960731A (en) * | 2012-12-19 | 2013-03-13 | 杭州滢宝生物科技有限公司 | Method for preparing antioxidative reishi shell-broken spore powder and product |
| CN102960731B (en) * | 2012-12-19 | 2013-11-13 | 杭州滢宝生物科技有限公司 | Method for preparing antioxidative reishi shell-broken spore powder and product |
| CN103478536A (en) * | 2013-08-13 | 2014-01-01 | 当涂县瑞龙果树种植专业合作社 | Anti-fatigue of purple sweet potato glutinous rice flour and preparation method thereof |
| CN103690574A (en) * | 2013-12-25 | 2014-04-02 | 南京中科药业有限公司 | Poria-containing traditional Chinese medicine combination for enhancing immunity and preparation method of poria-containing traditional Chinese medicine combination |
| CN104997022A (en) * | 2015-06-19 | 2015-10-28 | 青岛浩大海洋保健食品有限公司 | Marine health care capsule having efficacy of immunoregulation |
| CN107495350A (en) * | 2017-10-13 | 2017-12-22 | 延边韩工坊健康制品有限公司 | A kind of health food and preparation method with function of physical fatigue alleviation |
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| Publication number | Publication date |
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| CN1232184C (en) | 2005-12-21 |
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