CN110742270A - Health food for enhancing immunity and preparation method thereof - Google Patents
Health food for enhancing immunity and preparation method thereof Download PDFInfo
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- CN110742270A CN110742270A CN201910905031.4A CN201910905031A CN110742270A CN 110742270 A CN110742270 A CN 110742270A CN 201910905031 A CN201910905031 A CN 201910905031A CN 110742270 A CN110742270 A CN 110742270A
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- health food
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Epidemiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
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- Nutrition Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of health-care food, and particularly discloses health-care food for enhancing immunity, which is prepared from the following raw materials in parts by weight: 1-7 parts of astragalus membranaceus, 1-7 parts of glossy privet fruit, 2-6 parts of dendrobium officinale and 2-7 parts of ganoderma spore powder. The invention also discloses a preparation method of the health food for enhancing immunity. The health food has good synergistic effect on enhancing immunity due to the combination of the raw materials of astragalus, glossy privet fruit, dendrobium officinale and ganoderma lucidum spore powder, and the four selected raw materials are food raw materials or raw materials allowed by the state for health food, and the dosage is strictly limited in a certain range, so that the health food is absolutely safe and effective and has no toxic or side effect. In addition, the oleanolic acid in the granules or tablets prepared by the method is identified according with relevant regulations, the content of the crude polysaccharide in the astragalin A and the crude polysaccharide in the granules or tablets prepared by the method is in accordance with the relevant regulations, the solubility is good, the mouthfeel is good, the cost is low, the preparation method is simple, no special equipment is needed, and the method is suitable for industrial production.
Description
Technical Field
The invention belongs to the field of health-care food, and particularly relates to health-care food for enhancing immunity and a preparation method thereof.
Background
With the rapid development of economy, the living cost and mental stress of people are increased, so that a series of bad lives, such as sitting for a long time over duty, staying up overnight, overeating and the like, are slowly generated by many people, the bad lives can seriously damage the immune system of the body, the immunity is reduced, the susceptibility to diseases is caused, and the living quality of people is greatly influenced. Therefore, in order to achieve good health and improve quality of life, it is urgently required to enhance immunity.
Enhancing immunity refers to enhancing autoimmunity by some means. Immunity is the body's own defense mechanism, and is the body's ability to recognize and destroy any foreign body (virus, bacteria, etc.) that invades from the outside, to treat aged, damaged, dead, denatured self cells, and to recognize and treat mutant cells and virus-infected cells in the body. Modern immunology considers that improving immunity is a physiological reaction for human body to recognize and eliminate "isohexia". The body performs this function by the immune system, and there are several ways to enhance immunity, such as the consumption of beneficial or selectively healthy foods, especially children or mentally stressed adults, which require attention to the enhancement of immunity.
The immunity proposed by modern medicine has similar function with the "healthy qi" of the theory of traditional Chinese medicine. "healthy qi" is closely related to the lung, spleen and kidney, so it is said that "the theory of deficiency origin is" treating deficiency with three principles ": it is also indicated for deficiency syndromes of the lung, spleen and kidney. On the day of lung qi and five zang organs, the spleen is the mother of skeleton, and the kidney is the root of life, it is used for lung, spleen and kidney deficiency . The lung is covered by the skin and hair, which is the barrier to immunity. The skin and hair is the defense line to resist the invasion of exogenous pathogens, and the strength of the action depends on the sufficiency of lung qi and the normal opening and closing of the striae, so the lung defense is the first barrier to resist exogenous pathogens. If the lung is deficient, the opening and closing function fails, the lung fails to keep the defense, and exogenous pathogenic factors will enter the body due to deficiency. The spleen governs transportation and transformation, and is the source of acquired root and generation of qi and blood. Plum donoyuan said: the diseases are caused by internal injury to the spleen and stomach, and the deficiency of qi and blood in the spleen and stomach can not maintain the normal physiological functions of the viscera, but can not resist the invasion of pathogenic factors, thereby causing various diseases. Kidneys are the innate root and the root of life, and are most closely related to immunity. Kidneys store essence, generate original qi, and maintain the growth of human body, which is the prime motive force for life activities. The kidney is full of essential qi, the healthy qi is stored, and the zang-fu organs function normally. If the innate essence is deficient, or the acquired qi is deficient due to recuperation or mistreatment, the essence and qi are damaged, and the healthy qi is deficient, various pathological changes are likely to occur. In a word, the traditional Chinese medicine mainly maintains the internal balance of yin and yang of an organism by regulating the functions of the lung, the spleen and the kidney to achieve the effect of enhancing the immunity of the organism.
The invention provides a health food for enhancing immunity with a new formula for deficiency of the lung, spleen and kidney, deficiency of both qi and yin and low immunity, and a preparation prepared by using the formula has stable quality, safety and no toxicity, and has strong application prospect in large-scale production.
Disclosure of Invention
The invention aims to provide the immunity-enhancing health food which can better enhance the immunity of people with mental lassitude and low resistance.
The invention also aims to provide a preparation method of the health-care food for enhancing immunity, which is simple and feasible, and the prepared health-care food for enhancing immunity has good formability, melting property and taste, and is very suitable for industrial production.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a health food for enhancing immunity comprises the following raw materials in parts by weight: 1-7 parts of astragalus membranaceus, 1-7 parts of glossy privet fruit, 2-6 parts of dendrobium officinale and 2-7 parts of ganoderma spore powder.
Preferably, the health food for enhancing immunity comprises the following raw materials in parts by weight: 2-3 parts of astragalus membranaceus, 2-3 parts of glossy privet fruit, 1-2 parts of dendrobium officinale and 1-2 parts of ganoderma lucidum spore powder.
The health food for enhancing immunity is prepared from 1 part of extract powder, 2-30 parts of filler, 1-7 parts of flavoring agent and 1-6 parts of adhesive; the extract powder is prepared by decocting astragalus, glossy privet fruit and dendrobium officinale with 2-9 times of water, filtering the obtained extract, concentrating under reduced pressure, drying, and adding ganoderma spore powder.
The filler is one or more of sucrose, dextrin, microcrystalline cellulose and starch. The use of lactose was abandoned in view of its intolerance.
Preferably, the fillers are dextrin, sucrose, microcrystalline cellulose and starch, since experiments show that: meanwhile, dextrin, sucrose, microcrystalline cellulose and starch are added, so that the granule has good formability and flowability.
The flavoring agent is aspartame, the main medicine of the product is traditional Chinese medicine, and the bitter taste of the traditional Chinese medicine cannot be shielded only by the sweetness of the sucrose powder, so the aspartame is selected as the flavoring agent, and the experimental result shows that the aspartame is selected as the flavoring agent and has the best taste.
The adhesive is 70-90% of ethanol, and experimental results show that: the soft material is moderate when 70-90% ethanol adhesive is used for granulation, the prepared granules are moderate in color and luster and hardness, and the forming rate is high.
Preferably, the temperature of the reduced pressure concentration is 40-80 ℃, the vacuum degree is 0.01-0.09 MPa, and the concentrated solution is concentrated to the relative density of 1.2-1.45.
The concentration temperature is too high, which affects the active ingredients which are easy to damage the ganoderma lucidum spores, so the concentration is carried out at low temperature as much as possible, but the concentration time is too long, which also reduces the active ingredients which are easy to damage the ganoderma lucidum spores, so the concentration is carried out at lower temperature under the condition that the vacuum degree is 0.01 MPa-0.09 MPa, which can keep the active ingredients of the ganoderma lucidum spores to the utmost extent and improve the curative effect of the product. In addition, the relative density of the clear paste is controlled to be 1.2-1.45, so that subsequent granulation can be facilitated, and the obtained health-care food for enhancing immunity has good formability and meltability.
The drying temperature is 40-80 ℃, and the drying time is 3-9 h. Under the drying condition, the full and efficient drying can be ensured, and the active ingredients in the raw material medicines can be ensured not to be damaged.
The invention also discloses a preparation method of the health food for enhancing immunity, which comprises the following steps: mixing the extract powder, filler and correctant, adding binder to make into soft material, granulating, drying, and grading to obtain granule.
The health food for enhancing immunity further comprises 1-5 parts of lubricant magnesium stearate. The lubricant is magnesium stearate, and as the main drug of the tablet is a traditional Chinese medicine, the cooperation of talcum powder and magnesium stearate and the independent use of magnesium stearate are considered, experimental results show that the tablet surface of the tablet is smooth and easy to disintegrate, so that the magnesium stearate is finally selected as the lubricant in order to save cost.
The preparation method of the health food for enhancing immunity comprises the following steps: mixing the extract powder, filler and correctant, adding binder to make into soft material, granulating, drying, grading, adding lubricant, mixing, and making into tablet.
The raw medicinal materials adopted by the invention are specifically described as follows:
astragalus root: sweet and warm. It enters lung and spleen meridians. Has the functions of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, promoting fluid production and nourishing blood. It can tonify qi of spleen and lung, invigorate spleen, replenish qi, nourish blood, promote the production of body fluid, nourish source, tonify lung qi, strengthen superficies, check sweating, and prevent invasion of exogenous pathogens. Is a good product for tonifying spleen and lung, nourishing blood and promoting fluid production, strengthening body resistance and eliminating evil.
Glossy privet fruit: sweet, bitter and cool. It enters liver and kidney meridians. Has the effects of nourishing liver and kidney, nourishing yin and blood, and nourishing yin and strengthening body resistance. The astragalus root has the synergistic effects of tonifying lung, spleen and kidney, dredging and tonifying the three main points, tonifying qi and generating blood, nourishing yin and promoting the production of body fluid, strengthening body resistance and eliminating pathogenic factors.
Dendrobium officinale: sweet and slightly cold. It enters stomach and kidney meridians. Has the functions of benefiting stomach, promoting the production of body fluid, tonifying kidney and nourishing yin. The composition can be used together with fructus Ligustri Lucidi to enhance the effects of nourishing yin and promoting fluid production, and is especially suitable for patients with deficiency of qi and yin and hypoimmunity.
Ganoderma lucidum spore powder: the Ganoderma spore powder is Ganoderma spore, and has the same effect as Ganoderma. Sweet and neutral. It enters heart, lung, liver and kidney meridians. Has the functions of invigorating qi and tranquilizing mind. The product is always a good product for tonifying qi, generating blood and nourishing and strengthening. And has the effects of tonifying heart-qi, benefiting heart-blood, tranquilizing mind, and nourishing heart. The composition can be used together with radix astragali, fructus Ligustri Lucidi and herba Dendrobii to enhance qi invigorating, hematogenesis, yin nourishing, salivation promoting, heart nourishing, tranquilizing, and mind tranquilizing effects. It is most suitable for patients with deficiency of qi and yin, hypoimmunity, and uneasiness.
Compared with the prior art, the invention has the following beneficial effects:
(1) the applicant researches various raw materials with the function of enhancing immunity extensively, tries a large amount of combinations, and discovers that the combination of astragalus, glossy privet fruit, dendrobium officinale and ganoderma lucidum spore powder has a better synergistic effect on enhancing immunity. In addition, the raw materials selected for preparing the health food are food raw materials or raw materials allowed by the state to be used for the health food, and the dosage is strictly limited within a certain range, so the health food is absolutely safe and effective and has no toxic or side effect.
(2) The identification of the effective component oleanolic acid (the component of glossy privet fruit) in the immunity-enhancing health food conforms to the relevant regulations, the contents of the crude polysaccharide (the component of ganoderma lucidum spore powder) and the astragalus membranaceus A (the component of astragalus membranaceus) in the product conform to the relevant regulations, and the safety, the effectiveness and the no toxic or side effect of the product are further proved.
(3) The preparation method provided by the invention is simple to operate, short in production period, free of special equipment, low in cost, high in yield, more stable and reliable in quality of the prepared granules or tablets, convenient for patients to take, and suitable for large-scale production and application.
Detailed Description
Example 1
(1) Decocting 690g of astragalus membranaceus, 650g of glossy privet fruit and 360g of dendrobium officinale with 2 times of water to obtain an extracting solution, filtering, concentrating under reduced pressure (the temperature is 40 ℃, and the vacuum degree is 0.04MPa) to the relative density of 1.20, drying, and adding 380g of ganoderma spore powder to prepare 920g of health-care food extract powder for enhancing immunity;
(2) pulverizing the immunity enhancing health food extract powder and sucrose, sieving with 80 mesh sieve, mixing the immunity enhancing health food extract powder, microcrystalline cellulose 920g, starch 830g, dextrin 1150g, sucrose 1250g and aspartame 12g uniformly to obtain a mixture, adding 75% ethanol to make into soft material, granulating, drying (at 40 deg.C for 3 hr), grading, and packaging into 5 g/bag (1000 bags).
Example 2
(1) Decocting 600g of astragalus membranaceus, 640g of glossy privet fruit and 370g of dendrobium officinale with 9 times of water to obtain an extracting solution, filtering, concentrating under reduced pressure (the temperature is 70 ℃, and the vacuum degree is 0.09MPa) to the relative density of 1.45, drying, and adding 360g of ganoderma spore powder to obtain 870g of immunity-enhancing health-care food extracting paste powder;
(2) pulverizing the immunity enhancing health food extract powder and sucrose, sieving with 80 mesh sieve, mixing the immunity enhancing health food extract powder, 970g microcrystalline cellulose, 980g starch, 1280g dextrin, 1000g sucrose and 10g aspartame uniformly to obtain a mixture, adding 90% ethanol to obtain a soft material, granulating, drying (at 80 deg.C for 5 hr), grading, and packaging into 5 g/bag (1000 bags).
Example 3
(1) Decocting 650g of astragalus, 700g of glossy privet fruit and 390g of dendrobium officinale with 5 times of water to obtain an extracting solution, filtering, concentrating under reduced pressure (the temperature is 60 ℃, and the vacuum degree is 0.01MPa) to the relative density of 1.25, drying, and adding 370g of ganoderma lucidum spore powder to prepare 900g of health-care food extract powder for enhancing immunity;
(2) crushing the immunity enhancing health food extract powder and cane sugar, sieving the crushed powder by a 80-mesh sieve for later use, uniformly mixing the immunity enhancing health food extract powder, 840g of microcrystalline cellulose, 1250g of starch, 1100g of dextrin, 940g of cane sugar and 15g of aspartame to obtain a mixture, adding 70% of B to prepare a soft material, granulating the soft material, drying (the temperature is 45 ℃ and the time is 9 hours), grading, and subpackaging into 5 g/bag, wherein the total bag is 1000 bags.
Example 4
(1) Adding 7 times of water into 610g of astragalus, 620g of glossy privet fruit and 380g of dendrobium officinale to decoct, filtering the obtained extract, concentrating under reduced pressure (the temperature is 55 ℃, and the vacuum degree is 0.02MPa) to the relative density of 1.35, drying, adding 400g of ganoderma lucidum spore powder, and preparing 850g of health-care food extract powder for enhancing immunity;
(2) pulverizing the immunity enhancing health food extract powder and sucrose, sieving with 80 mesh sieve, mixing the immunity enhancing health food extract powder, microcrystalline cellulose 1200g, starch 1100g, dextrin 930g, sucrose 970g and aspartame 11g uniformly to obtain a mixture, adding 85% ethanol to prepare a soft material, granulating the soft material, drying (at 60 deg.C for 7h), grading, and packaging into 5 g/bag (1000 bags in total).
Example 5
(1) Decocting 660g of astragalus membranaceus, 630g of glossy privet fruit and 340g of dendrobium officinale with 6 times of water to obtain an extracting solution, filtering, concentrating under reduced pressure (the temperature is 80 ℃, and the vacuum degree is 0.05MPa) to reach the relative density of 1.30, drying, and adding 390g of ganoderma spore powder to prepare 880g of health-care food extract powder for enhancing immunity;
(2) crushing the immunity enhancing health food extract powder and cane sugar, sieving the crushed powder by a 80-mesh sieve for later use, uniformly mixing the immunity enhancing health food extract powder, 1000g of microcrystalline cellulose, 1050g of starch, 1200g of dextrin, 1010g of cane sugar and 14g of aspartame to obtain a mixture, adding 80% ethanol to prepare a soft material, granulating the soft material, drying (the temperature is 50 ℃ and the time is 6 hours), grading, adding 4g of magnesium stearate, uniformly mixing, pressing into tablets, and subpackaging into 0.4 g/tablet and 12500 tablets in total.
Example 6
(1) 630g of astragalus, 650g of glossy privet fruit and 360g of dendrobium officinale are added with 3 times of water for decoction to obtain an extracting solution, the extracting solution is filtered, decompressed and concentrated (the temperature is 50 ℃, the vacuum degree is 0.03MPa) to the relative density of 1.40, dried and added with 320g of ganoderma lucidum spore powder to prepare 840g of immunity-enhancing health-care food extracting paste powder;
(2) crushing the health food extract powder for enhancing immunity and sucrose, sieving the crushed powder with a 80-mesh sieve for later use, uniformly mixing the health food extract powder for enhancing immunity, 990g of microcrystalline cellulose, 1000g of starch, 1000g of dextrin, 1130g of sucrose and 12g of aspartame to obtain a mixture, adding 85% ethanol to prepare a soft material, granulating the soft material, drying (the temperature is 65 ℃ and the time is 8 hours), granulating, adding 3g of magnesium stearate, uniformly mixing, pressing into tablets, and subpackaging into 0.4 g/tablet and 12500 tablets in total.
Comparative example 1
The procedure of example 1 was followed except that the mixture was concentrated under reduced pressure to a relative density of 1.45.
Comparative example 2
The procedure of example 1 was followed except that 65% ethanol was further added to prepare a soft mass.
Comparative example 3
The operation is the same as that of example 1 except that the four medicines of astragalus, glossy privet fruit, dendrobium officinale and ganoderma lucidum spore powder are decocted by adding water simultaneously.
Comparative example 4
The procedure of example 5 was followed except that 4g of magnesium stearate was not added and mixed to homogeneity.
Comparative example 5
The procedure of example 1 was followed except that the glossy privet fruit was removed from the formulation.
Comparative example 6
The procedure of example 1 was followed except that the ganoderma lucidum spore powder was removed from the formulation.
1. And (4) safe toxicology test:
the health food for enhancing immunity prepared in the embodiment is subjected to a safety toxicology test, and the specific test method and conclusion are as follows:
(1) acute oral toxicity test in rats:
190-210g SPF-level Wistar rats with half female and half male were selected and subjected to a test after fasting for 16h, and orally administered twice at a dose of 15.0g/kg.BW at an interval of 6 hours, and after the test subjects were administered, the rats were continuously observed for 14 days, and the body weight, the toxic performance and the death condition of the rats were recorded as shown in the following Table 1.
TABLE 1
As shown in Table 1, rats of both sexes were gavaged with 15.0g/kg BW for 14 days, and no significant toxic manifestation was observed during the test period, and no death of the animals occurred, and no abnormality of each major organ was observed in the necropsy.
(2) Biochemical examination result of blood
Separating serum, and measuring main blood biochemical indexes with Hitachi 7080 automatic biochemical analyzer, wherein the measurement items comprise aspartate Aminotransferase (AST), alanine Aminotransferase (ALT), alkaline phosphatase (ALP), urea nitrogen (BUN), Creatinine (CREA), Total Protein (TP), Albumin (ALB), blood Glucose (GLU), total bilirubin (T.BIL), total cholesterol (T.CHO), Triglyceride (TG), Creatine Kinase (CK), gamma-GT (gamma-glutamyltransferase) and LDH (lactate dehydrogenase); determination of serum K Using EX-180 full-automatic electrolyte Analyzer+(Potassium) and Na+(sodium) and Cl-(chloride) ion.
The results of the 31-day gavage of each administration group on biochemical indicators of blood of male rats (Mean ± s.d., n ═ 10) are shown in table 2 below, and the results of the 31-day gavage of each administration group on biochemical indicators of blood of female rats (Mean ± s.d., n ═ 10) are shown in table 3 below.
TABLE 2
TABLE 3
As can be seen from tables 2 and 3, the biochemical index of the blood of the rats in the groups with different doses was not significantly different from that in the blank control group.
(3) Examination result of T lymphocytes
At the end of 31 days of administration and 28 days of withdrawal, 0.5mL of whole blood was taken from the abdominal aorta of the rat and assayed according to the kit instructions, and the assay items included T lymphocyte typing (CD 3)+、CD4+And CD8+). The effect of 31 days gavage and 28 days of withdrawal on T lymphocyte typing in rats (Mean ± s.d.) results are shown in table 4 below.
TABLE 4
As can be seen from Table 4, the test drugs had no significant effect on the typing of T lymphocytes in rats at different doses for 31 days after administration and 28 days after withdrawal.
2. Quality testing of the preparation:
the quality of the strong-immunity health food prepared in each of examples 1 to 6 and comparative examples 1 to 6 was tested according to the general guidelines of the four preparations and internal standards of the company of 2015 edition of the chinese pharmacopoeia, and the specific test results are shown in table 5:
TABLE 5
As can be seen from the results in table 5, the immunity-enhancing health foods obtained by the formulation and the preparation method of the present invention are better in examples 1 to 6 as a whole, and the contents of crude polysaccharides (components of ganoderma spore powder) and astragaloside a (components of astragalus root) in the comparative examples 1 to 6 are relatively unstable compared with the contents of crude polysaccharides and astragaloside a in the examples, and oleanolic acid (components of fructus ligustri lucidi) is also unstable; the processes of comparative examples 1 to 6 are difficult to granulate, and the granules or tablets are relatively poor in moldability, taste and solubility.
3. An immunity enhancing experiment:
the immunity enhancing effect of the health food prepared in example 1 and comparative examples 5-6 is respectively determined, and the specific determination method and conclusion are as follows:
(1) experimental animals: kunming mouse (2 months old) with weight of 18-20 g and half female and half male, which is purchased from the experimental animals of Schlegzeda, Hunan;
(2) medicine preparation: the granules prepared in the example 1 and the comparative examples 5 to 6 are prepared into oral liquid by using distilled water;
(3) the experimental method comprises the following steps: mice were randomly divided into 4 groups, including 3 sample groups and 1 control group, with 20 mice each. The samples were perfused for 5 days each day, 0.5 ml/chicken erythrocyte 1h after the administration on day 5 was injected into the abdominal cavity, the control group was given physiological saline of equal volume, the mice were sacrificed by cervical leukosis after 45min, the peritoneal fluid smear was taken, then the slide was placed in a box with wet gauze, incubated at 37 ℃ for 30min in an incubator, taken out, and rinsed in physiological saline to remove non-adherent cells. Air-drying, fixing with methanol solution for 5min, dyeing with 4% Giemsa-Ruite's solution for 3 min, rinsing with distilled water, and air-drying. The number of macrophages in each tablet under an oil lens is 200, the phagocytosis percentage and the phagocytosis index are calculated according to the following formula, and the influence results of each group on the phagocytosis function of mouse abdominal macrophages are shown in the following table 6.
Percent (%) phagocytosis (number of phagocytic cells that phagocytose chicken red blood cells/200 macrophages) x 100% phagocytic index (total number of phagocytic chicken red blood cells/200 macrophages)
TABLE 6
(*P<0.05)
The experimental results show that: compared with the normal saline group, the embodiment group and the comparison example group, the statistical treatment on the difference of the phagocytosis indexes of the two groups has significance, the health food prepared by the comparison example has a general immunity enhancing effect, and the health food prepared by the embodiment of the invention can better improve the phagocytosis of mouse abdominal cavity macrophages, so that the health food has a better immunity enhancing effect.
4. Clinical cases
Zhangzhi, female, 30 years old, premature infant, congenital weakness and sickliness, low immunity and easy sickening, the health food granule of the invention is taken once a day, one bag once, after three months, the vigor is obviously more vigorous, the physique is obviously enhanced, and the sickliness is not frequently sickened any more.
The Duqi health food granule is taken once a day, one bag is taken once every day, after three months, the appetite becomes good, the energy is more vigorous in work, and the work efficiency is higher.
The health food tablet is taken by a male in 55 years old one month after operation three times a day, 4 tablets are taken each time, the pain of the wound is relieved after one week, and the wound is basically healed after two weeks.
Claims (10)
1. The health food for enhancing immunity is characterized by comprising the following raw materials in parts by weight: 1-7 parts of astragalus membranaceus, 1-7 parts of glossy privet fruit, 2-6 parts of dendrobium officinale and 2-7 parts of ganoderma spore powder.
2. The immunity-enhancing health food as claimed in claim 1, which is prepared from 1 part of extract powder, 2 to 30 parts of filler, 1 to 7 parts of flavoring agent and 1 to 6 parts of binder;
the extract powder is prepared by decocting astragalus, glossy privet fruit and dendrobium officinale with 2-9 times of water, filtering the obtained extract, concentrating under reduced pressure, drying, and adding ganoderma spore powder.
3. The immunity-enhancing health food as claimed in claim 2, wherein the filler is at least one of sucrose, dextrin, microcrystalline cellulose and starch.
4. The immunity-enhancing health food as claimed in claim 2, wherein the corrigent is aspartame.
5. The immunity-enhancing health food as claimed in claim 2, wherein the binder is 70 to 90% ethanol.
6. The immunity-enhancing health food as claimed in claim 2, wherein the concentration under reduced pressure is carried out at a temperature of 40 to 80 ℃ and a vacuum degree of 0.01 to 0.09MPa, and the concentration is carried out to a concentrated solution having a relative density of 1.2 to 1.45.
7. The immunity-enhancing health food as claimed in claim 2, wherein the drying temperature is 40 to 80 ℃ and the drying time is 3 to 9 hours.
8. The immunity-enhancing health food as claimed in claim 2, further comprising 1 to 5 parts of magnesium stearate as a lubricant.
9. The method for preparing the immunity-enhancing health food according to any one of claims 2 to 7, comprising: mixing the extract powder, filler and correctant, adding binder to make into soft material, granulating, drying, and grading to obtain granule.
10. The method for preparing an immunity-enhancing health food according to claim 8, comprising: mixing the extract powder, filler and correctant, adding binder to make into soft material, granulating, drying, grading, adding lubricant, mixing, and making into tablet.
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| CN112190662A (en) * | 2020-10-12 | 2021-01-08 | 安徽林兰药业有限公司 | Ling Hu electuary and preparation method thereof |
| CN113069510A (en) * | 2021-04-08 | 2021-07-06 | 中国热带农业科学院热带生物技术研究所 | Composition for enhancing immunity and preparation method and application thereof |
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Application publication date: 20200204 |