CN103830558A - Anti-aging composition and preparation method thereof - Google Patents
Anti-aging composition and preparation method thereof Download PDFInfo
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- CN103830558A CN103830558A CN201210487087.0A CN201210487087A CN103830558A CN 103830558 A CN103830558 A CN 103830558A CN 201210487087 A CN201210487087 A CN 201210487087A CN 103830558 A CN103830558 A CN 103830558A
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Abstract
The invention relates to an anti-aging youth-retaining pharmaceutical composition and a preparation method thereof. The anti-aging pharmaceutical composition provided by the invention is prepared from the following raw materials: ginseng, rhizoma polygonati, radix rehmanniae, radix asparagi, poria cocos and honey. The anti-aging youth-retaining pharmaceutical composition provided by the invention can be made into any common dosage form for oral administration, has the functions of nourishing the kidneys and moistening the spleen, tonifying the spleen and replenishing qi, nourishing blood and promoting fluid production and clearing lung heat and reducing fire, and can enhance the immunological functions of human bodies, maintain the beauty and keep youth and resist fatigue and aging. The pharmaceutical composition has the advantages of obvious effect, convenience in taking, good mouthfeel and no toxic or side effect.
Description
Technical field
The present invention relates to a kind of composition and method of making the same for metabolic disease, particularly a kind of antidotal natural activity composition and method of making the same.
Background technology
Along with growth in the living standard, people have urgent requirement to preventing and treating aging, life lengthening, raising vitality and quality of life.At present in medical science, relevant old and feeble definition is the generally weak of the various functions of organism, and opposing environmental injury and recover phenomenon or the process of the reduction of homoiostasis ability.Chinese medicine, in the development course of thousands of years, has been done long-term effort and exploration in slow down aging each side, has formed unique theory and system, has accumulated rich experience.The causes of senescence of the traditional Chinese medical science, has " natural endowment opinion ", " opinion of lacking of proper care after one's birth " and " kidney qi loss is said ", " pathogen is stopped up Sheng and said ", " internal organs void declines ", " imbalance of YIN and YANG is said " etc.Chinese medicine on to the understanding of old and feeble reason, is paid much attention to the effect of function and energy, emphasizes very much that again negative and positive coordinate the significance to health.Skin is the organ the most easily appearing in aging course, and skin aging shows as head and appearance: man's hair is gradually grey, and volume upper eyelid wrinkle is existing, occurs senile plaque etc., pachylosis, dry, telangiectasis.Skin aging is a complicated biological phenomena, is mainly divided into two kinds of forms of naturally-aged and photoaging, and now clear and definite skin aging is the coefficient result of endogenous factor and extrinsic factor.Professional person studies discovery, much Chinese medicine contains the Multiple components such as each seed amino acid, lipid, polysaccharide, pectin, vitamin, trace element, organic acid, alkaloid, saponin, there is removing interior free yl, enhancing body oxidation resistance, improve skin microcirculation, improve collagen fibers of skin and collagen content, regulate the effects such as immunologic function.Along with the in-depth of China's Gerontological Research Center, this class medicine comes into one's own day by day.Modern Chinese medicine is especially under the guidance of theory of Chinese medical science, adopt the research method of tradition and modern science to excavate, screen, verify various effective methods and medicine, delay because the degeneration that increases the each organs and systems of human body causing age changes, change its old and feeble sign, extend its life-span, improve vitality.
Summary of the invention
Primary and foremost purpose of the present invention is that the problem existing for prior art provides a kind of composition and method of making the same with defying age, looks improving and the skin nourishing, present composition prescription is simple, the medical material that the raw material using is integration of edible and medicinal herbs, has nourishing kidney profit spleen, invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, effect of lung heat clearing pathogenic fire reducing, can strengthen immune function of human body, looks improving and the skin nourishing, resisting fatigue, anti-aging.Preparation method simple possible of the present invention, stable processing technique, easy to use, cheap.
For realizing object of the present invention, one aspect of the present invention provides a kind of compositions with anti-senescence function, comprises following raw material: Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria.
The weight portion proportioning wherein, with the composition material of anti-senescence function is:
Radix Ginseng 1 ~ 20, Rhizoma Polygonati 0.5 ~ 10, Radix Rehmanniae 0.2 ~ 10, Radix Asparagi 0.5 ~ 7, Mel 0.5 ~ 8, Poria 1 ~ 10.
Particularly, the weight portion proportioning of described raw material is: Radix Ginseng 5 ~ 15, Rhizoma Polygonati 3 ~ 9, Radix Rehmanniae 2.5 ~ 7, Radix Asparagi 1 ~ 6, Mel 1 ~ 7, Poria 3 ~ 7; More preferably: Radix Ginseng 8 ~ 11, Rhizoma Polygonati 4 ~ 7, Radix Rehmanniae 2.5 ~ 5, Radix Asparagi 3 ~ 6, Mel 3 ~ 4, Poria 4 ~ 6.
Anti-apolexis composition of the present invention is selected by having nourishing kidney profit spleen, invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel and the Poria of the effect of lung heat clearing pathogenic fire reducing and integration of edible and medicinal herbs combine and are prepared from, and can strengthen immune function of human body, looks improving and the skin nourishing, resisting fatigue, anti-aging.These integration of edible and medicinal herbs Chinese crude drugs are used in combination, make the active component in each medical material produce synergism, promote effect of defying age, looks improving and the skin nourishing.
The present invention adopts scientific method formula, is raw materials usedly integration of edible and medicinal herbs Chinese crude drug plant, wherein:
Radix Ginseng is Araliaceae herbaceos perennial, and property is flat, sweet in the mouth, micro-hardship, tepor; Return spleen, lung meridian, heart channel; Have strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, effect of the Fructus Alpiniae Oxyphyllae of calming the nerves; Be mainly used in treating that impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency multiple, the disease of all qi-blood-body fluid deficiencies.
The ancient pharmacy ancient books and records Shennong's Herbal about Chinese medicine of China is classified Radix Ginseng as top grade, says its " main tonifying five ZANG-organs, peace spirit determine soul, and spasmolytic is throbbed with fear, improving eyesight, happy Fructus Alpiniae Oxyphyllae, takes and have the effect of making light of one's life by commiting suicide and prolonging life for a long time ".Modern pharmacology research shows, ginsenoside and ginseng polysaccharide significantly suppress the synthetic of fat brown pigment in rat cerebral cortex and liver; In Radix Ginseng Rubra, maltol can be combined with interior free yl and be suppressed the peroxidization of lipid in Mouse Liver, reduces the accumulation of lipofuscin etc., shows anti-aging effects.The main cause of human skin aging is poor circulation, and metabolism reduces, and skin elasticity weakens.Owing to containing multiple ginsenoside, aminoacid, vitamin and mineral in Radix Ginseng, there is the blood circulation that promotes subcutaneous capillary, increase the nutrition supply of skin, prevent arteriosclerosis, the effects such as regulation of skin water balance.So its energy delay skin aging, prevents xerosis cutis dehydration, increases the elasticity of skin, thereby it is tender to play protection skin gloss, prevents and reduce the effect of wrinkle of skin, and Radix Ginseng active substance also has the reducing property of check melanin, makes skin pure white smooth.
Rhizoma Polygonati, has another name called Rhizoma Polygonati Cirrhifolii, Caput Gallus domesticus ginseng.For the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati (Polygonatum kingianum Coll.et Hemsl.), Rhizoma Polygonati (Polygonatum sibiricum Red.) or Polygonatum cyrtonema Hua (Polygonatumcyrtonema Hua.).Property flat, sweet in the mouth, return lung, spleen, kidney channel.There is nourishing kidney lung moistening, effect of invigorating the spleen and replenishing QI; Be mainly used in lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough of YIN-deficiency of the lung and kidney etc.; Weakness of the spleen and stomach.Both tonifying spleen-yin, again strengthening the spleen gas; Deficiency of kidney essence obtains dizzy, soreness of the waist and knees, early whitening of beard and hair and quenching one's thirst etc.
Rhizoma Polygonati is conventional tonic Chinese medicine, has effect of spleen reinforcing lung moistening, supplementing QI and nourishing YIN, is used for the treatment of the diseases such as body void is weak, shortness of breath and palpitation, dryness of the lung dry cough, tinea corporis.Research in recent years shows, Rhizoma Polygonati plant contains alkaloid, flavone, quinones, lignanoid, polysaccharide, steroidal saponin and trace element etc.Research worker is with Rhizoma Polygonati oral liquid 0.2, the continuous gavage mice of 0.4ml/d 4 weeks (making respectively the positive, negative control with Oral Liquid Radix Panacis Quinquefolii and water respectively), after swimming 90min, put to death, this oral liquid of result can significantly reduce the heart, liver lipid peroxide (LPO) generates (P<0.01), increase glutathione peroxidase activity and blood superoxide dismutase (SOD) vigor, and be dose dependent; Compared with positive controls, Rhizoma Polygonati oral liquid suppresses the heart, liver LPO generative capacity obviously increases, and is also dose dependent, shows that it has anti-ageing anti-old effect.Also proving that polygonatum polysaccharide is external has an antioxidation, this composition can suppress generation spontaneous and lipid peroxidation product malonaldehyde (MDA) induction, oxygen-derived free radicals is had to direct scavenging action, thus polygonatum polysaccharide antioxidation and anti-aging aspect there is certain effect.Ming Dynasty's well-known doctor's Li Shizhen (1518-1593 A.D.) is recorded Rhizoma Polygonati in Compendium of Material Medica can " mend all void, replenishing essence marrow ", can make " the five internal organs are in harmonious proportion, muscle sufficiency, and bone marrow is strong, its power multiplication, not old for many years, color clear, turns white more black, dedentition is more raw ".Modern study shows, the effective ingredient of Rhizoma Polygonati can strengthen cardiac contractile force, increases coronary artery blood flow, reduces blood pressure and blood glucose, improves body immunity, thereby delays the aging of body.The water-ol preserved material concentrated solution of Rhizoma Polygonati, can be used as cosmetic colors.The beriberi medicine syrup made from Rhizoma Polygonati and bath gel all have good efficacy.The hair nourishing cream, black hair suppurative mastitis, the black hair scalp pomade that coordinate other drug to make with Rhizoma Polygonati, can make poliosis become hair color, and have certain hair regrowth.
Radix Asparagi is liliaceous plant.Have another name called Radix Asparagi.Cold in nature, sweet in the mouth, micro-hardship.Return liver, lung, kidney lung meridian.Have and calm the nerves, nourish heart, lung moistening, tonification, nourishing kidney, the curative effects such as blood pressure lowering and loosening bowel to relieve constipation.There is replenishing YIN and removing heat, effect of lung moistening nourishing kidney.Be used for controlling fever due to yin deficiency, cough haematemesis, lung abscess, laryngopharynx swelling and pain, quench one's thirst, the disease such as constipation.All on the books in the each large classics of ancients.
Radix Asparagi has nourishing YIN to relieve dryness, the lung heat clearing function of promoting the production of body fluid, and cures mainly that dryness of the lung dry cough, pertussis expectorant are sticky, dry throat and mouth, dryness of the intestine constipation.The nourishing YIN Chinese medicine of the conventional integration of edible and medicinal herbs of Radix Asparagi system, the nineties in 20th century, people have carried out comparatively deep research to its pharmacological action.Once there is Radix Asparagi water extraction liquid to extend the report in silkworm life-span.Recently, there is people to gavage Radix Asparagi water extraction liquid to the continuous 7d of mice, 2 and all significant prolongation normobaric hypoxia time-to-live and frozen water swimming times of 4g crude drug/kg dosage.The continuous 30d of this two dosage gavages, and can improve the low brain of D-galactose Aging mice, hepatic tissue Na
+, K
+-atpase activity, and reduce upborne brain, liver and plasma lipid peroxide metabolite malonaldehyde (MDA) content.Radix Asparagi alcohol extract 2g crude drug/kg gavages also has anti-D-galactose to cause the old and feeble effect of mice, significantly improves the Na in mice aging model brain, liver plasma membrane and testis mitochondrion
+, K
+-ATP enzyme, brain superoxide dismutase (SOD) and testis mitochondrion activity of glutathione peroxidase, and reduce MDA content and the LPO of these tissues, recover mouse aging brain activities of nitric oxide synthase and nitric oxide level.Radix Asparagi nanometer formulation can improve the anti-D-galactose of Radix Asparagi and cause old and feeble effect.Antioxidation is the important mechanisms of Radix Asparagi defying age and antiinflammatory.Confirm the statement that traditional Chinese medical science ancient books " legendary god of farming's book on Chinese herbal medicine " " takes for a long time the QI invigorating of making light of one's life by commiting suicide, prolongs life not hungry " Radix Asparagi.Radix Asparagi has the foster skin of preserving youthful looks, brightens the beauty functions of moist, black palpus hair color, the firm tooth of teeth consolidating.Modern pharmacology finds especially, and the contained aspartic acid of Radix Asparagi has non-oxidizability, can stop the oxidation of unsaturated fatty acid, can nurse one's health usefulness, delays and treat the keratinization of skin, keeps the soft and smooth and moistening of skin.
Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant, cool in nature, and sweet in the mouth, hardship enter the heart, liver, kidney channel.Have clearing away heat and cooling blood, effect of YIN nourishing and the production of body fluid promoting, is mainly used in calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, and hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, sends out speckle dermexanthesis.
The chemical composition of Radix Rehmanniae mainly contains iridoid and glycoside thereof, sugar, aminoacid, organic acid, sterol, flavone and vitamin etc.Wherein, sterols mainly contains cupreol, stigmasterol, micro-campesterol; Flavone mainly contains luteolin, mountain balsam flavin; Iridoid and glycoside thereof mainly comprise catalpol, dihydro catalpol, acetylcatalpol, Herba Leonuri glycoside, aucubin, single sweet special power glycoside, sweet special power glycoside, sterol glycoside, iridoid A, B, C, D, Acteoside, compound saccharic, cerebroside, chlorination iridoid glycoside, Rehmannioside A, B, C, the bitter glycoside of Radix Rehmanniae etc.
Radix Rehmanniae is the key medicine in tonification class Chinese medicine, and history is loaded in Shennong's Herbal, classifies as top grade.Adopt Fe
2+-cysteine system is brought out hepatomicrosome lipid peroxidation, TAB-fluorescence method is determined mda content, Radix Rehmanniae water extract and ethanol extract can have the effect of antagonism hepatomicrosome lipid peroxidation in various degree, and pointing out this may be an aspect of Radix Rehmanniae tonification, Antiageing effect mechanism.Recently, research to Radix Rehmanniae anti-aging effects mechanism biases toward the research to Radix Rehmanniae Preparata, Radix Rehmanniae Preparata has the effect that reduces mouse brain mitochondrion monoamine oxidase, MAO (MAO) activity, also can obviously improve the activity of nitricoxide synthase (NOS) and superoxide dismutase (SOD) in the aging model mouse brain tissue of galactose induction, nitric oxide (NO) content is increased, thus the effect of performance slow down aging.The beautification function of Radix Rehmanniae is mainly to moisten skin, improve visual and auditory acuity, and black beard and hair, " repairing true secret formula " thinks that Radix Rehmanniae " takes one hundred days face as Flos persicae, takes 3 years and make us living forever and never die ".
Poria, is commonly called as Poria, Song Ling, Poria, and for colonizing in the fungi plant on pinaster root, shape is as Rhizoma Dioscoreae esculentae, crust pitchy, the inside white or pink.Its protozoa is the dry sclerotia of On Polyporaceae Poria, and multiparasitization is in the root of Pinus massoniana Lamb or Pinus densiflora.Property is put down, and sweet in the mouth, light, enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, reaches by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.Linggui zhugan decoction, decoction of four noble drugs, four Siberian cocklebur soup etc. are all the conventional prescriptions that have Poria compatibility.
Poria main component is β-pachyman (accounting for dry weight 93%) and triterpenoid compound Pachymic acid, pachymic acid, 3 beta-hydroxy Pilus Caprae seu Ovis steroid trienic acids.In addition still gummy, chitin, protein, fat, sterol, lecithin, histidine, choline and lithium salts etc..Ancient times, pancake made by Poria by imperial palace, thinks that normal food can keep fit stalwartness, life prolonging.Research worker is by Water Extract of Poria and hippocampus in neonatal rats neurocyte primary cell preincubate 24h, again cell and sodium azide are hatched to cultivation, with do not carry out preincubate group and find more afterwards, Poria group can obviously be resisted ability and the micro-tubular structure disorder of the neurocyte mitochondrion reduction MTT that sodium azide causes, maintain function and the micro-tubular structure of cell mitochondrial, delaying senility, has control neurodegenerative diseases as the effect of alzheimer disease, vascular dementia and parkinson etc.Someone adopts 4 groups of old rats, every day Indian bread polysaccharide formulation gastric infusion.Measure the content of plurality of enzymes-monoamine oxidase, MAO (MAO), malonaldehyde (MDA) and the superoxide dismutase (T-SOD and Cu-SOD) of enzyme related to aging in serum, aging metabolite and removing ageing products.Result shows, pachyman administration group, compared with aged matched group, can increase T-SOD and Cu-SOD activity in serum in various degree, reduces MDA content, has cold-resistant, resisting fatigue and anti-aging effects.Modern medicine study data shows, Poria can not only significantly improve the immunologic function of human body, and can make HbO2 Oxyhemoglobin in blood capillary discharge more oxygen, the enough oxygen of providing organization's cell (comprising skin, mucosa, hair etc.), delaying cell aging, regenerates rapidly cell, skin care, increase elasticity and gloss, strengthen youthful vigor and beautification function thereby play.
Mel is a kind of daily health products, the honey of nectar brew in Nidus Vespae that what to be insecticide Apis adopt from the spending of flowering plant.Mel is a kind of nutritious natural nourishing food, is also one of the most frequently used tonic.According to one's analysis, the trace element that contains the multiple organic acid such as the plurality of inorganic salt close with human serum concentration and vitamin, ferrum, calcium, copper, manganese, potassium, phosphorus and useful health, and fructose, glucose, amylase, oxidase, reductase etc., there is nourishing, moisturize, effect of removing toxic substances, beauty face-whitening-nourishing, loosening bowel to relieve constipation.Mel sweet in the mouth; Property is put down; Enter spleen; Stomach; Lung; Large intestine channel; There is harmonizing the spleen and stomach; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Loosening bowel to relieve constipation; Skin moistening granulation promoting; Removing toxic substances.The empty pain of main gastral cavity abdomen; Xeropulmonary cough; Dryness of the intestine constipation; Conjunctival congestion; Aphtha; Ulcer being unable to heal; Rubella pruritus; Burn due to hot liquid or fire; Effect that brothers' (army's skin) are split.
Chinese medicine thinks, Mel have strengthen the spleen and stomach, the function of nourishing the lung to arrest cough, loosening bowel to relieve constipation.Modern study shows, contains the multiple nutritional components such as abundant saccharide, protein, aminoacid, vitamin and mineral in Mel, has very strong medical care effect.Research discovery of all times, Mel is outstanding for the effect of skin-nourishing health care.Every person that often drinks Mel, its skin quality all becomes fine and smooth whitening, soft and moist high resilience gradually.Given this, now increasing skin care item have all added honey component, make it to directly act on skin, bring into play better the effect of its care skin.
The present invention provides a kind of preparation method of the above-mentioned compositions with anti-senescence function on the other hand, comprises the steps:
1) weighting raw materials Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria, wherein pulverizes Radix Ginseng, Poria respectively, makes Radix Ginseng powder, Poria powder, for subsequent use;
2) crude drug Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi are mixed after Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi mixed material, add water, mixed material is carried out to heating extraction, collect extracting solution;
3) extracting solution is carried out to concentration, make the concentrated extract of Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi;
4) crude drug Poria powder, Radix Ginseng powder and Mel are joined to concentrated extract and mix, dry, to obtain final product.
Another aspect of the invention provides a kind of preparation method of the above-mentioned compositions with anti-senescence function, comprises the steps:
1) weighting raw materials Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria, wherein pulverizes Radix Ginseng, Poria respectively, makes Radix Ginseng powder, Poria powder, for subsequent use;
2) crude drug Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi are mixed after Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi mixed material, add water, mixed material is carried out to heating extraction, collect extracting solution;
3) extracting solution is carried out to concentration, make the concentrated extract of Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi;
4) crude drug Poria powder and Mel are joined to concentrated extract and mix, crushed after being dried, makes dry extract powder;
5) Radix Ginseng powder is joined in dry extract powder, mix homogeneously, to obtain final product.
Wherein, the granularity of Radix Ginseng powder described in step 1), Poria powder is 60-180 order.
Wherein, step 2) described in heating extraction comprise as follows step in sequence:
A) in mixed material, add water, soak, then carry out heating extraction for the first time, wherein, the weight of the water adding is 6-12:1 with the ratio of the gross weight of mixed material, and heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hour;
B) extracting solution filters for the first time, collects filtrate;
C) in filtering residue, add water, carry out heating extraction for the second time, wherein, the weight of the water adding is 6-12:1 with the ratio of the weight of mixture, and heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hour;
D) filter, the filtrate of twice filtration is merged.
Particularly, steps A) described in soak time be 20-90min, be preferably 30-60min; The weight of the water adding is preferably 8-10:1 with the ratio of the gross weight of mixed material; Heating extraction temperature is preferably 60-100 DEG C, more preferably 80-100 DEG C; The heating extraction time is preferably 2-3h; Step C) in the weight of water that adds and the ratio of the weight of mixture be 8-10:1; Heating extraction temperature is preferably 60-100 DEG C, more preferably 80-100 DEG C; The heating extraction time is preferably 2-3h.
Particularly, also comprise step e): in the filtering residue after filtering to heating extraction for the second time, add water, carry out heating extraction for the third time, wherein, the weight of the water adding is 6-12:1 with the ratio of the weight of mixture, and heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hour; Then filter, filtrate merges.
Especially, step e) in the weight of water that adds and the ratio of the gross weight of mixed material be preferably 8-10:1; Heating extraction temperature is preferably 60-100 DEG C, more preferably 80-100 DEG C; The heating extraction time is preferably 2-3h.
Wherein, in the process of concentration described in step 3), controlling temperature is 40-100 DEG C.
Particularly, described concentration is that extracting solution is carried out to evacuation concentrating under reduced pressure, and thickening temperature is 40-100 DEG C, is preferably 60-100 DEG C, and the relative pressure when concentrated is-0.05 ~-0.095MPa, is preferably-0.05 ~-0.07MPa.
Particularly, described concentration is extracting solution to be carried out to normal pressure concentrate, and thickening temperature is 40-100 DEG C, is preferably 60-100 DEG C, and the relative pressure when concentrated is 0Mpa.
Wherein, the relative density of concentrated extract described in step 3) is 1.1-1.7, is preferably 1.1-1.3, more preferably 1.2-1.3; Baking temperature described in step 4) is 40-75 DEG C, is preferably 50-70 DEG C; The granularity of described powder is 80-180 order, is preferably 100-180 order.
Another aspect of the invention provide a kind of by defying age that on the above-mentioned compositions described in arbitrary with anti-senescence function and pharmaceutics, acceptable auxiliary material combination is made, strengthen immune pharmaceutical preparation.
Wherein, the compositions with anti-senescence function of the present invention can be made clinical acceptable peroral dosage form by tradition or modern production technique with acceptable adjuvant on pharmaceutics.As powder, medicinal tea, granule, capsule, tablet, concentrated pill, drop pill, soft extract etc.Excipient substance used can be in starch, dextrin, magnesium stearate, essence, micropowder silica gel, Pulvis Talci, sucrose, microcrystalline Cellulose, Sodium Hydroxymethyl Stalcs, stevioside, glucose, lactose, poloxamer, PEG2000 ~ 6000 any one or multiple.Need clinically long-term prescription, make solid preparation storage convenient, patient takes facility, also meeting the market requirement more.Preferred dosage form is capsule, granule, tablet.
Anti-senescence function compositions tool of the present invention has the following advantages:
1, the anti-ageing compositions prescription compatibility science of preserving youthful looks of the present invention, formula is unique, and exact efficacy is safe, quality controllable;
2, the anti-ageing compositions of preserving youthful looks of the present invention has nourishing kidney profit spleen, invigorating the spleen and replenishing QI, and nourishing blood to promote the production of body fluid, effect of lung heat clearing pathogenic fire reducing, the active component in each medical material produces synergism, can strengthen immune function of human body, looks improving and the skin nourishing, resisting fatigue, anti-aging;
3, the anti-ageing combination of Chinese medicine material of preserving youthful looks of the present invention is the Chinese crude drug of integration of edible and medicinal herbs, can long-term taking, have no side effect, and anti-ageing medicine or health product defying age and the looks improving and the skin nourishing successful of preserving youthful looks of preparation;
4, the preparation method of the anti-ageing compositions of preserving youthful looks of the present invention is simple, process conditions gentleness, and with low cost, expense is low.
Detailed description of the invention
Further describe the beneficial effect of medicine of the present invention below by detailed description of the invention, these test examples have comprised that the present invention combines the pharmacodynamics test of the anti-ageing granule of preserving youthful looks (embodiment 1), the anti-ageing capsule of preserving youthful looks (embodiment 2).These embodiment are only exemplary, scope of the present invention are not formed to any restriction.It will be understood by those skilled in the art that and do not departing under formula thinking of the present invention, purposes scope and can the details of technical solution of the present invention and form modified or be replaced, but these amendments and replacement all fall within the scope of protection of the present invention.
The preserve youthful looks impact of Granules on Mouse activity of SOD in serum and MDA, NO level that test example 1 is anti-ageing
1, test material::
Kunming mouse: male and female half and half, body weight 20 ± 5g, is provided quality certification numbering: SCXK (capital) 2009-003 by dimension tonneau China's zoopery center.
The anti-ageing granule of preserving youthful looks: 2g/ bag (every bag containing crude drug 10g); Positive drug: vitamin E (East Sea pharmaceutical factory).
2, test method:
Get 60 of the healthy Kunming mouses of clean level, male and female half and half, be divided at random 6 groups, 10 every group, i.e. blank group, model control group, positive drug group, defying age granule high dose group (200mg/kg), middle dosage group (100mg/kg), low dose group (50mg/kg).Except blank group mouse back subcutaneous injection equal-volume 0.9% sodium chloride injection, all the other each groups are used D-galactose to press 120mg/kg back subcutaneous injection, once a day, continuous 30 days, prepare subacute aging model.Within the 21st day, start by the administration respectively of following method from modeling, once a day, continuous 10 days.Positive drug group mouse gavaging 25mg/kg vitamin E; The mice of high, medium and low dosage group gavages respectively 200,100, the anti-ageing granule of preserving youthful looks of 50mg/kg; Blank group and model control group mice gavage respectively equal-volume 0.9% sodium chloride injection.30min after last administration, gets blood from mouse orbit, and centrifugal (3000r/min, 10min) gets serum.Press serum superoxide dismutases (SOD), malonaldehyde (MDA) and nitric oxide (NO) test kit description mensuration activity of SOD in serum and MDA, NO level.Result of the test is in table 1.
Table 1 mice serum SOD activity and MDA, the comparison of NO level
Note: with the comparison of blank group,
*p < 001, with model control group comparison,
*p < 001
With the comparison of blank group, model control group mice serum SOD activity decreased, MDA, NO level raise, and difference all has statistical significance (P<0.01).High dose group, middle dosage group, low dose group mice serum SOD activity significantly improve compared with model control group, and serum MDA, NO level are compared with model to organizing remarkable decline, and difference all has statistical significance (P<0.01).High, medium and low dosage group mice serum SOD activity and MDA, NO level and blank group and the comparison of positive drug matched group, the equal not statistically significant of difference (P>0.05).Result of the test shows: the anti-ageing granule of preserving youthful looks can enhancing body be removed the ability of free radical, reduces the degree of histiocyte damage, has certain anti-aging effects; Its anti-aging effects intensity is close with vitamin E.
The impact of the anti-ageing Granules on Mouse GSH-Px in serum activity of preserving youthful looks of test example 2
1, test material:
Kunming mouse: male and female half and half, body weight 20 ± 5g, is provided quality certification numbering: SCXK (capital) 2009-003 by dimension tonneau China's zoopery center.
The anti-ageing granule of preserving youthful looks, 2g/ bag (every bag containing crude drug 10g).
2, test method:
Get 50 of Kunming mouses, male and female half and half, be divided at random 5 groups, 10 every group, be respectively blank group, model control group, the anti-ageing granule low dose group (50mg/kg) of preserving youthful looks, middle dosage group (100mg/kg), heavy dose of group (200mg/kg).Except blank mouse back subcutaneous injection equal-volume 0.9% sodium chloride injection, all the other each groups are used D-galactose to press 125mg/kg back subcutaneous injection, and every morning once, continuous 30 days, is prepared subacute aging model.In preparing model, administration every afternoon group gastric infusion once, successive administration 42 days.The mice of high, medium and low dosage group gavages respectively 200,100, the anti-ageing granule of preserving youthful looks of 50mg/kg; Blank group, model control group such as gavage every afternoon at the capacity normal saline.30min after last administration, mice is put to death, gets blood, prepares serum, measures the activity of GSH-Px in serum.Result of the test is in table 2.
The anti-ageing impact of granule on each group of mice serum GSH-Px activity of preserving youthful looks of table 2
Note: with model control group comparison.
*p<001,
*p<005.
The anti-ageing granule administration group of preserving youthful looks all can improve the activity of GSH-Px in mouse aging serum, and difference has significance (P<0.01). and point out the anti-ageing granule of preserving youthful looks can improve the activity of antioxidant enzyme.Accelerate the decomposition of free radical, there is the effect of good enhancing body oxidation resistance.
The anti-ageing impact of granule on immunocompromised mouse immune organ quality of preserving youthful looks of test example 3
1, test material:
Kunming mouse: male and female half and half, body weight 20 ± 5g, is provided quality certification numbering: SCXK (capital) 2009-003 by dimension tonneau China's zoopery center.
The anti-ageing granule of preserving youthful looks, 2g/ bag (every bag containing crude drug 10g); Prednisolone acetate, Guangdong Huanan Pharmaceutical Co., Ltd.
2, test method:
Get 60 of the healthy Kunming mouses of clean level, be divided at random 5 groups, every group 12, be respectively blank group, model control group, the anti-ageing granule high dose group (200mg/kg) of preserving youthful looks, middle dosage group (100mg/kg), low dose group (50mg/kg).Except blank group, other respectively organize mice gavage in the morning and give the prednisolone acetate of 40mg/kg, and afternoon, gavage gave the anti-ageing granule of preserving youthful looks of corresponding dosage; Model group mice gavage in the morning gives the prednisolone acetate of 40mg/kg, and afternoon, gavage gave isometric distilled water, successive administration 12 days.After last administration 1 hour, de-mice cervical vertebra is put to death, claim weight, get spleen and thymus, claim quality with electronic balance, calculate Thymus and spleen index (W): W
spleen=M
spleen/ M
body weight, W
thymus=M
thymus/ M
body weight.Result of the test is in table 3.
The anti-ageing impact of granule on immunocompromised mouse spleen index, thymus index of preserving youthful looks of table 3
Note: with the comparison of blank group matched group,
*p<001.With model control group comparison,
* *p<001,
*p<005.
Experimental result shows: with the comparison of blank group, the index and spleen index of model group mice, thymus index all significantly reduce (P<0.01), shows that prednisolone acetate causes immunodeficiency models success.The high, medium and low dosage group of the anti-ageing granule of preserving youthful looks all can significantly improve the index and spleen index of immunocompromised mice, and with model group comparison, difference has significant (P<0.01).Low, the middle dosage group of the anti-ageing granule of preserving youthful looks can significantly improve the thymus index (P<0.05 or P<0.01) of immunocompromised mice.Experimental result shows, causes mice form under immunosuppressant condition prednisolone acetate, and the anti-ageing granule of preserving youthful looks can increase mouse thymus and index and spleen index.
The anti-ageing impact of granule on normal mouse red blood cell sum of preserving youthful looks of test example 4
1, test material:
Kunming mouse: male and female half and half, body weight 20-24g, is provided quality certification numbering: SCXK (capital) 2009-003 by dimension tonneau China's zoopery center.
The anti-ageing granule of preserving youthful looks, 2g/ bag (every bag containing crude drug 10g).Cyclophosphamide (Hengrui Medicine Co., Ltd., Jiangsu Prov.).
2, test method:
30 healthy mices of random selection, are divided into 3 groups at random.Every group 10, be respectively blank group, immunosuppressant group and the anti-ageing groups of grains of preserving youthful looks.Immunosuppressant group and anti-ageing preserve youthful looks groups of grains respectively in the 1st, give mouse peritoneal injection Isodose cyclophosphamide when fasting 12 (25mg/kg, before administration) 13,5 day morning; The anti-ageing groups of grains oral anti-ageing granule of preserving youthful looks in afternoon (100mg/kg) of preserving youthful looks; Immunosuppressant group gives the distilled water of same volume afternoon.Within the 1st, 2,3,4 weeks after administration, carry out the blood sampling of eye socket venous plexus, carry out red blood cell count(RBC).Result of the test is in table 4.
The impact of the anti-ageing granule of preserving youthful looks of table 4 on immunosuppressed mice erythrocyte sum (
× 10
9)
Note: with the comparison of blank group
*p<005,
*p<001; With relatively Δ p<005 of inhibition group
The red blood cell count(RBC) result of the test of And Utilization of CTX-Immunosuppressed-mice is known, with the comparison of immunosuppressant group, anti-ageing red blood cell count(RBC) of preserving youthful looks groups of grains 4th week has clear improvement (p<0.05), illustrates that the immunosuppressant of the anti-ageing Granules on Mouse of preserving youthful looks has obvious resistant function.
The impact of the anti-ageing Granules on Mouse swimming time of preserving youthful looks of test example 5
1, test material:
Kunming mouse: male and female half and half, body weight 20 ~ 28g, is provided quality certification numbering: SCXK (capital) 2009-003 by dimension tonneau China's zoopery center;
The anti-ageing granule of preserving youthful looks, 2g/ bag (every bag containing crude drug 10g); Positive drug: QINGCHUN BAO (0.5g/ grain, the honest youth is protected pharmaceutcal corporation, Ltd).
2, test method:
Get 50 of Kunming mouses, body weight 20 ~ 28g, male and female half and half, be divided at random five groups, every group 10, be respectively blank group, positive controls, the anti-ageing granule low dose group (100mg/kg) of preserving youthful looks, middle dosage group (200mg/kg), heavy dose of group (300mg/kg).Anti-ageing preserve youthful looks granule administration group mice respectively gavage give anti-ageing granule 100mg/kg, 200mg/kg, the 300mg/kg of preserving youthful looks; Positive controls mice gives 200mg/kg QINGCHUN BAO; Blank group waits the normal saline of capacity, continuously gavage 7 days.After last administration, 1h is the load with body weight 10% by mouse tail, puts into depth of water 25cm, in the swimming cylinder that water temperature is 30 ± 1 DEG C, records the swimming time of mice.Result of the test is in table 5.
The impact of the anti-ageing Granules on Mouse swimming time of preserving youthful looks of table 5
Note: with the comparison of blank group
*p<001; With relatively Δ p<005 of positive controls, Δ Δ p<001.
With the comparison of blank group, the basic, normal, high dosage group of the anti-ageing granule of preserving youthful looks all can significantly improve mice swimming time (p<0.01), and the antifatigue effect that the anti-ageing granule of preserving youthful looks has is described.
The impact of the anti-ageing Granules on Mouse the survival time under hypoxic condition of preserving youthful looks of test example 6
1, test material:
Kunming mouse: male and female half and half, body weight 20 ~ 28g, is provided quality certification numbering: SCXK (capital) 2009-003 by dimension tonneau China's zoopery center;
The anti-ageing granule of preserving youthful looks, 2g/ bag (every bag containing crude drug 10g); Positive drug: three strangle slurry oral liquid (the magnificent pharmaceutical Co. Ltd in Sichuan).
Test method:
Get 50 of healthy Kunming mouses, body weight 20 ~ 28g, male and female half and half, be divided at random five groups, every group 10, be respectively blank group, positive controls, the anti-ageing granule low dose group (100mg/kg) of preserving youthful looks, middle dosage group (200mg/kg), heavy dose of group (300mg/kg).Anti-ageing preserve youthful looks granule administration group mice respectively gavage give anti-ageing granule 100mg/kg, 200mg, the 300mg/kg of preserving youthful looks; Positive controls mice gives three of 200mg/kg and strangles slurry oral liquid; Blank group waits the normal saline of capacity, continuously gavage 7 days.After last administration, 1h puts into mice 10g is housed, and in the airtight wide mouthed bottle of 250mL of sodica calx, records the time-to-live of mice.Result of the test is in table 6.
The impact of the anti-ageing Granules on Mouse the survival time under hypoxic condition of preserving youthful looks of table 6
Note: with the comparison of blank group
*p<005,
*p<001; With relatively Δ p<005 of positive controls.
With the comparison of blank group, the anti-ageing granule low dose group of preserving youthful looks can improve the anoxia in mice time-to-live (P<0.05), the middle and high dosage group of the anti-ageing granule of preserving youthful looks can significantly improve the anoxia in mice time-to-live (P<0.01), illustrates that the anti-ageing granule of preserving youthful looks has antifatigue effect.
The anti-ageing therapeutical effect of capsule to chloasma of preserving youthful looks of test example 7
1, physical data:
Treatment group: the anti-ageing capsule of preserving youthful looks of the present invention (0.3g/ grain, every containing crude drug 1.5g) observes through 166 routine triers the effect of understanding functions of removing chloasma altogether;
Matched group: adopt positive control drug: BAZHEN YIMU JIAONANG (0.28g/ grain, Sanghai Pharmaceutical Factory) is observed the effect of understanding functions of removing chloasma to 83 routine triers,
Trier is women, and in age 18-60 year, the visible chloasma of Head And Face perusal, without symptoms such as any sufferings.Adopt and self take medicine cross-reference mode of the present invention and compare.
2, instructions of taking:
Treatment group: oral 2 times of every day, each 2, early, take evening, within 2 months, is 1 course for the treatment of.
Positive controls: every day 3 times, each 3, early, middle and late taking, 2 months is 1 course for the treatment of.
Anemia of pregnant woman's forbidding, experimenter cuts out other health product and uses other whitening and speckle dispelling class cosmetics at duration of test.
3, treatment standard:
Clinical diagnosis and curative effect determinate standard, " dermatological ", " the practical Surgery of Chinese Medicine " of the chloasma of formulating with reference to Dermatology Professional Committee of CAIM (Chinese Association Of Integrative Medicine) pigment group are drafted.
1, the variation of mottle size: with length and the width of the tested front and back of the same chloasma of tape measure, calculate mottle area;
2, the variation of mottle shade: according to Institute of Geography, Academia Sinica's development and design, brown (Y+M+BK i.e. Huang+magenta+black folded color) colour atla in " practical standard colour atla " (first edition) that Mapping Press publishes for 1992 is the criterion of chloasma shade: I degree (15,20,5), II degree (30,40,10), III degree (40,60,15).
4, freckle effect judgement
1, substantially cure: chloasma disappears substantially;
2, effective: chloasma color obviously shoals, area reduces >1/3, does not produce new chloasma;
3, take a turn for the better: chloasma color shoals, area reduces≤1/3, does not produce new chloasma;
4, invalid: chloasma color and area are without significant change.
5, result of the test
Experimental result is as shown in table 7.
The therapeutical effect of table 7 to chloasma
Note: with matched group comparison
*p<001.
The curative effect for the treatment of group is apparently higher than matched group, and basic cure rate and obvious effective rate are also apparently higher than matched group; Treatment group patient is when facial colour spot disappears, and conscious spirit takes a turn for the better, energetic, sleep improvement, and the gynaecopathias such as some patients were menoxenia, dysmenorrhea also obtain effective; Two groups of cases are showed no untoward reaction during treating.
The anti-ageing opsonic action of capsule to sub-health state of preserving youthful looks of test example 8
1, physical data:
Treatment group: the anti-ageing capsule of preserving youthful looks of the present invention (0.3g/ grain, every containing crude drug 1.5g) is observed and understood the effect that regulates sub-health state through 130 routine triers altogether;
Matched group: adopt positive control drug: oral oryzanol tablets (30mg/ sheet, Sanghai Pharmaceutical Factory) is observed and understood the effect that regulates sub-health state 126 routine triers.
Trier age 18-40 year, there is the symptoms such as insomnia and dreamful sleep, fatigue and weakness, lassitude, dizzy nose heave, sensation of oppression over the chest with shortness of breath, inappetence, susceptible to lose temper due to restlessness, spontaneous perspiration hyperhidrosis.Adopt and self take medicine cross-reference mode of the present invention and compare.
2, instructions of taking:
Treatment group: oral 2 times of every day, each 2, early, take evening, within 2 months, is 1 course for the treatment of.
Positive controls: every day 3 times, each 3, early, middle and late taking, 2 months is 1 course for the treatment of.3, result of the test
Subhealth state clinical symptoms test and appraisal: insomnia and dreamful sleep, fatigue and weakness, lassitude, dizzy nose heave, sensation of oppression over the chest with shortness of breath, inappetence, susceptible to lose temper due to restlessness, spontaneous perspiration hyperhidrosis.Semiography adopts sxemiquantitative integration method.Scoring system is as follows: do not say person automatically, 5 points of cardinal symptom notes, 3 points of minor symptom notes; The inquiry person of saying, 4 points of cardinal symptom notes, 2 points of minor symptom notes; The symptom person of cutting in and out, 3 points of cardinal symptom notes, 1 point of minor symptom note; Asymptomatic person, remembers 0 point.Result of the test is in table 8.
The anti-ageing opsonic action of capsule to sub-health state of preserving youthful looks of table 8
Note: with this group before treatment
*p<001; With comparison Δ p<005 after treatment of control group.
Known from experimental result: treatment, clinical symptoms integration reduces, before and after treatment, self-contrast has statistical significance (p<0.01), and the anti-ageing capsule of preserving youthful looks can improve sub-health population clinical symptoms.
Test example 9 acute toxicity tests
Choosing NIH is 20 of healthy mices, and body weight is 18-20 gram, male and female half and half.First fasting 12 hours before experiment, when experiment, with the dose of the tolerant Cmax of white mice, maximum volume, by the anti-ageing the present invention granule of preserving youthful looks (0.3g/ grain, every containing crude drug 1.5g) to be made into concentration be 30% suspension, according to 15g/kg body weight gastric infusion 1 time, observe 7 days.Experimental result: do not measure compositions of the present invention to mice LD50 value, this dosage is equivalent to 961 times of clinical dosage, medicine of the present invention is greater than 15g/kg to the maximum tolerated dose of mice lavage administration, shows that medicine of the present invention or functional food are without acute toxic reaction, and safety is good.
Test example 10 long term toxicity tests
Animal feeding was observed after 1 week, selecting the normal NIH of indices is 96 of healthy mices, male and female half and half, body weight is 18-20g, be divided at random 4 groups, 24 of every treated animals, i.e. the anti-ageing granule high dose group (0.18g/kg) of preserving youthful looks of the present invention, middle dosage group (0.36g/kg), low dose group (0.54g/kg) and matched group.When off-test, randomly draw 20 for every group and measure indices, residue is put to death and is cutd open inspection.
High, medium and low dosage group dosage is equivalent to 40 times, 80 times, 160 times of quantity, is equivalent to respectively 1,2,4 times of pharmacodynamics effective dose.The anti-ageing granule distilled water suspension preparation of preserving youthful looks, by 44mg/kg, 88mg/kg, 176mg/kg body weight per os gastric infusion, every day 2 times, matched group gives the starch suspension of equivalent.Detect index with general performance, body weight, hematology and Biochemical Indices In Serum before and after animals administer, routine urinalysis, organ weights equipotential, and be aided with animal and respectively organize the pathological examination of internal organs, the toxicity situation of overall merit medicine.
Result shows: medicament capsule of the present invention changes without the significance difference opposite sex the weight of animals, and animal growth is normal; Every Index for examination of high, medium and low dosage treated animal shows no obvious abnormalities; Histopathologic examination's result demonstration, three dosage treated animals are respectively organized internal organs no abnormality seen.Showing that medicine of the present invention has no long term toxicity reaction, is safe medication.
Below in conjunction with embodiment, the present invention will be further described.
The preparation of the anti-ageing granule of preserving youthful looks of embodiment 1 the present invention
1) prepare raw material (kg) according to following weight proportion:
Radix Ginseng 10, Rhizoma Polygonati 5, Radix Rehmanniae 2.5, Radix Asparagi 3, Mel 4, Poria 6
Wherein, Poria, Radix Ginseng are ground into respectively to granularity and are 60-100 object Poria powder, Radix Ginseng powder, for subsequent use;
2) Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously are placed in Multifunctional Chinese medicine extraction pot, add tap water to soak 30min, the weight of the tap water wherein adding is 9:1 with the ratio of raw material gross weight;
3) open multi-function extractor power supply and heat, be heated to 100 DEG C, remain at this temperature constant temperature and extract after 2 hours and filter, obtain that extracting solution is for subsequent use for the first time;
4) in filtering residue, add tap water, the weight of the tap water adding is 6:1 with the ratio of raw material gross weight, heating extraction, and heating-up temperature is 100 DEG C, extraction time is 2 hours, filters and obtains extracting solution for the second time;
5) 2 extracting solution merging are placed in vacuum high energy evaporation concentrator and carry out concentrating under reduced pressure, make relative density and be 1.2 extractum, wherein, the relative pressure of concentrating under reduced pressure is for-0.07MPa(is taking an atmospheric pressure as 0, pressure while controlling concentrating under reduced pressure with respect to an atmospheric pressure is-0.07MPa), thickening temperature is 80 DEG C;
6) in extractum, add Poria powder, Radix Ginseng powder and Mel, carry out drying under reduced pressure processing after mix homogeneously at 50 DEG C, the relative pressure of drying under reduced pressure is-0.07MPa, and being dried to moisture content and being 5% rear pulverizing, to make granularity be 180 order composition powders;
7) composition powder is mixed with adjuvant dextrin, alcohol granulation, dry, make the anti-ageing granule of preserving youthful looks.
Wherein, heating extraction temperature is not limited to 100 DEG C, and heating-up temperature is all applicable to the present invention at 60-100 DEG C; Constant temperature extraction time was not limited to 2 hours, and extraction time was all applicable to the present invention at 1-4 hour.
The preparation of the anti-ageing capsule of preserving youthful looks of embodiment 2 the present invention
1) prepare raw material (kg) according to following weight proportion:
Radix Ginseng 8, Rhizoma Polygonati 4, Radix Rehmanniae 3, Radix Asparagi 4, Mel 4, Poria 4
Wherein, Poria, Radix Ginseng are ground into respectively to granularity and are 100-180 object Poria powder, Radix Ginseng powder, for subsequent use;
2) Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously are placed in Multifunctional Chinese medicine extraction pot, add tap water to soak 30min, the weight of the tap water wherein adding is 8:1 with the ratio of raw material gross weight;
3) open multi-function extractor power supply and heat, be heated to 100 DEG C, remain on constant temperature at this temperature and extract filtration after 2 hours, obtain extracting solution for the first time;
4) in filtering residue, add tap water, the weight of the tap water adding is 8:1 with the ratio of raw material gross weight, heating extraction, and heating-up temperature is 100 DEG C, extraction time is 2 hours, filters and obtains extracting solution for the second time;
5) 2 extracting solution are merged to be placed in vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, make relative density and be 1.1 extractum, wherein, the relative vacuum degree in concentration process is-0.07MPa that thickening temperature is 70 DEG C;
6) in extractum, add Poria powder and Mel, then at 70 DEG C, carry out drying under reduced pressure processing, the relative pressure of drying under reduced pressure is-0.08MPa, and being dried to moisture content is 4% rear pulverizing, and making granularity is 100 object dry extract powder;
7) dry extract powder is mixed with Radix Ginseng fine powder, pack in capsulae vacuus, make the anti-ageing capsule of preserving youthful looks.
The preparation of the anti-ageing sheet of preserving youthful looks of embodiment 3 the present invention
1) prepare raw material (kg) according to following weight proportion:
Radix Ginseng 9, Rhizoma Polygonati 3, Radix Rehmanniae 3, Radix Asparagi 5, Mel 4, Poria 3
Wherein, Poria, Radix Ginseng are ground into respectively to granularity and are 120-180 object Poria powder, Radix Ginseng powder, for subsequent use;
2) Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously are placed in Multifunctional Chinese medicine extraction pot, add tap water to soak 50min, the weight of the tap water wherein adding is 9:1 with the ratio of raw material gross weight;
3) open multi-function extractor power supply and heat, be heated to 85 DEG C, remain on constant temperature at this temperature and extract 3 hours, then filter, obtain extracting solution for the first time;
4) add tap water 2 times in filtering residue point, heating extraction 2 times, the temperature of each heating extraction is 85 DEG C, and the weight of the tap water adding is 9:1 with the ratio of raw material gross weight, and extraction time is 3 hours, filters and obtains extracting solution 2 times;
5) carry out atmospheric evaporation after 3 extracting solution are merged concentrated, make relative density and be 1.3 extractum, wherein, concentrated relative pressure is 0MPa, and thickening temperature is 100 DEG C;
6) in extractum, add Poria powder and Mel, carry out drying under reduced pressure processing under then at 65 DEG C, the relative pressure of drying under reduced pressure is-0.08MPa, and being dried to moisture content is 5% rear pulverizing, and making granularity is 100 order dry extract powder;
7) dry extract powder is mixed with Radix Ginseng fine powder, adjuvant, granulation, and dry, compacting is in flakes.
The preparation of the anti-ageing tea of preserving youthful looks of embodiment 4 the present invention
1) prepare raw material (kg) according to following weight proportion:
Radix Ginseng 10, Rhizoma Polygonati 4, Radix Rehmanniae 5, Radix Asparagi 5, Mel 4, Poria 6;
Wherein, Poria, Radix Ginseng are ground into respectively to granularity and are 80-120 object Poria powder, Radix Ginseng powder, for subsequent use;
2) Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously are placed in Multifunctional Chinese medicine extraction pot, add tap water to soak 40min, the weight of the tap water wherein adding is 10:1 with the ratio of raw material gross weight;
3) open multi-function extractor power supply and heat, be heated to 80 DEG C, remain on constant temperature at this temperature and extract 2.5 hours, then filter, obtain extracting solution for the first time;
4) add tap water 2 times in filtering residue point, heating extraction 2 times, the temperature of each heating extraction is 80 DEG C, and the weight of the tap water adding is 10:1 with the ratio of raw material gross weight, and extraction time is 2.5 hours, filters and obtains extracting solution 2 times;
5) carry out atmospheric evaporation after 3 extracting solution are merged concentrated, make relative density and be 1.3 extractum, wherein, concentrated relative pressure is 0MPa, and thickening temperature is 100 DEG C
6) in extractum, add Poria powder and Mel, then at 55 DEG C, carry out drying under reduced pressure processing, the relative pressure of drying under reduced pressure is-0.06MPa, and being dried to moisture content is 4% rear pulverizing, and making granularity is 150 order dry extract powder;
7) dry extract powder is mixed with Radix Ginseng fine powder, pack in filter paper bag, make teabag.
The preparation of the anti-ageing concentrated pill of preserving youthful looks of embodiment 5 the present invention
1) prepare raw material (kg) according to following weight proportion:
Radix Ginseng 11, Rhizoma Polygonati 5, Radix Rehmanniae 5, Radix Asparagi 6, Mel 3, Poria 5;
Wherein, Poria, Radix Ginseng are ground into respectively to granularity and are 100-140 object Poria powder, Radix Ginseng powder, for subsequent use;
2) Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously are placed in Multifunctional Chinese medicine extraction pot, add tap water to soak 60min, the weight of the tap water wherein adding is 9:1 with the ratio of raw material gross weight;
3) open multi-function extractor power supply and heat, be heated to 85 DEG C, remain on constant temperature at this temperature and extract 2 hours, then filter, obtain that extracting solution is for subsequent use for the first time;
4) add tap water 2 times in filtering residue point, heating extraction 2 times, the temperature of each heating extraction is 85 DEG C, and the weight of the tap water adding is 9:1 with the ratio of raw material gross weight, and extraction time is 2 hours, filters and obtains extracting solution 2 times;
5) 3 extracting solution are merged to be placed in vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, make relative density and be 1.3 extractum, wherein, the relative vacuum degree in concentration process is-0.06MPa that thickening temperature is 65 DEG C;
6) in extractum, add Poria powder, Radix Ginseng fine powder and Mel, then at 60 DEG C, carry out drying under reduced pressure processing, the relative pressure of drying under reduced pressure is-0.07MPa, and being dried to moisture content is 5% rear pulverizing, and making granularity is 100 object composition powders;
7), by composition powder and appropriate water pill, 75 DEG C dry, use medicinal charcoal coating, packs, and to obtain final product.
The preparation of the anti-ageing drop pill of preserving youthful looks of embodiment 6 the present invention
1) prepare raw material (kg) according to following weight proportion:
Radix Ginseng 8, Rhizoma Polygonati 9, Radix Rehmanniae 6, Radix Asparagi 4, Mel 1, Poria 7;
Wherein, Poria, Radix Ginseng are ground into respectively to granularity and are 100-120 object Poria powder, Radix Ginseng powder, for subsequent use;
2) Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously are placed in Multifunctional Chinese medicine extraction pot, add tap water to soak 20min, the weight of the tap water wherein adding is 12:1 with the ratio of raw material gross weight;
3) open multi-function extractor power supply and heat, be heated to 80 DEG C, remain on constant temperature at this temperature and extract 1 hour, then filter, obtain that extracting solution is for subsequent use for the first time;
4) add tap water 2 times in filtering residue point, heating extraction 2 times, the temperature of each heating extraction is 80 DEG C, and the weight of the tap water adding is 12:1 with the ratio of raw material gross weight, and extraction time is 1 hour, filters and obtains extracting solution 2 times;
5) 3 extracting solution are merged to be placed in vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, make relative density and be 1.25 extractum, wherein, the relative vacuum degree in concentration process is-0.06MPa that thickening temperature is 60 DEG C;
6) in extractum, add Poria powder and Mel, then at 60 DEG C, carry out drying under reduced pressure processing, the relative pressure of drying under reduced pressure is-0.07MPa, and being dried to moisture content is 5% rear pulverizing, and making granularity is 120 object dry extract powder;
8) dry extract powder is mixed with Radix Ginseng fine powder, add poloxamer F68 and the PEG6000 of molten condition, after mix homogeneously, medicinal liquid is put into insulation fluid reservoir, under 80 DEG C of insulations, the mixture of thawing is splashed in cooling dimethicone, condensation cured becomes ball, after taking-up drains, suck remaining dimethicone with filter paper, packaging, to obtain final product.
The preparation of the anti-ageing soft extract of preserving youthful looks of embodiment 7 the present invention
1) prepare raw material (kg) according to following weight proportion:
Radix Ginseng 15, Rhizoma Polygonati 7, Radix Rehmanniae 7, Radix Asparagi 3, Mel 7, Poria 3;
Wherein, Poria, Radix Ginseng are ground into respectively to granularity and are 80-100 object Poria powder, Radix Ginseng powder, for subsequent use;
2) Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi mix homogeneously are placed in Multifunctional Chinese medicine extraction pot, add tap water to soak 90min, the weight of the tap water wherein adding is 6:1 with the ratio of raw material gross weight;
3) open multi-function extractor power supply and heat, be heated to 60 DEG C, remain on constant temperature at this temperature and extract 4 hours, then filter, obtain that extracting solution is for subsequent use for the first time;
4) add tap water 2 times in filtering residue point, heating extraction 2 times, the temperature of each heating extraction is 60 DEG C, and the weight of the tap water adding is 8:1 with the ratio of raw material gross weight, and extraction time is 4 hours, filters and obtains extracting solution 2 times;
5) 3 extracting solution are merged to be placed in vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, make relative density and be 1.2 extractum, wherein, the relative vacuum degree in concentration process is-0.05MPa that thickening temperature is 65 DEG C;
6) in extractum, add Poria powder and Mel, then at 60 DEG C, carry out constant pressure and dry, being dried to moisture content is 6% rear pulverizing, and making granularity is 80 object dry extract powder;
8) dry extract powder is mixed with Radix Ginseng fine powder, add sucrose, and add 1/2 water of sucrose amount and 0.1% tartaric acid.Heating is tempered, and constantly stirs, until be concentrated into " wire drawing state ", to obtain final product.
Although the present invention discloses as above with preferred embodiments; so it is not in order to limit the present invention, any person of ordinary skill in the field, without departing from the spirit and scope of the present invention; when doing a little change and improvement, therefore protection scope of the present invention is when being defined and be as the criterion with claim.
Claims (10)
1. there is a compositions for anti-senescence function, it is characterized in that comprising following raw material: Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria.
2. there is as claimed in claim 1 the compositions of anti-senescence function, it is characterized in that the weight portion proportioning of described raw material is: Radix Ginseng 1 ~ 20, Rhizoma Polygonati 0.5 ~ 10, Radix Rehmanniae 0.2 ~ 10, Radix Asparagi 0.5 ~ 7, Mel 0.5 ~ 8, Poria 1 ~ 10.
3. there is as claimed in claim 2 the compositions of anti-senescence function, it is characterized in that the weight portion proportioning of described raw material is: Radix Ginseng 5 ~ 15, Rhizoma Polygonati 3 ~ 9, Radix Rehmanniae 2.5 ~ 7, Radix Asparagi 1 ~ 6, Mel 1 ~ 7, Poria 3 ~ 7.
4. a preparation method as described in as arbitrary in claim 1-3 with the compositions of anti-senescence function, comprises the steps:
1) weighting raw materials Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria, wherein pulverizes Radix Ginseng, Poria respectively, makes Radix Ginseng powder, Poria powder, for subsequent use;
2) crude drug Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi are mixed after Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi mixed material, add water, mixed material is carried out to heating extraction, collect extracting solution;
3) extracting solution is carried out to concentration, make the concentrated extract of Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi;
4) crude drug Poria powder, Radix Ginseng powder and Mel are joined to concentrated extract and mix, dry, to obtain final product.
5. preparation method as claimed in claim 4, the granularity that it is characterized in that Radix Ginseng powder described in step 1), Poria powder is 60-180 order.
6. the preparation method as described in claim 4 or 5, is characterized in that step 2) described in heating extraction comprise as follows step in sequence:
A) in mixed material, add water, soak, then carry out heating extraction for the first time, wherein, the weight of the water adding is 6-12:1 with the ratio of the gross weight of mixed material, and heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hour;
B) extracting solution filters for the first time, collects filtrate;
C) in filtering residue, add water, carry out heating extraction for the second time, wherein, the weight of the water adding is 6-12:1 with the ratio of the weight of mixture, and heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hour;
D) filter, the filtrate of twice filtration is merged.
7. preparation method as claimed in claim 6, it is characterized in that also comprising step e): in the filtering residue after filtering to heating extraction for the second time, add water, carry out heating extraction for the third time, wherein, the weight of the water adding is 6-12:1 with the ratio of the weight of mixture, heating-up temperature is 40-100 DEG C, and the heating extraction time is 1-4 hour; Then filter, filtrate merges.
8. preparation method as claimed in claim 6, is characterized in that steps A) described in soak time be 20-90min.
9. the preparation method as described in claim 4 or 5, is characterized in that in the process of concentration described in step 3), controlling temperature is 40-100 DEG C.
10. a preparation method as described in as arbitrary in claim 1-3 with the compositions of anti-senescence function, comprises the steps:
1) weighting raw materials Radix Ginseng, Rhizoma Polygonati, Radix Rehmanniae, Radix Asparagi, Mel, Poria, wherein pulverizes Radix Ginseng, Poria respectively, makes Radix Ginseng powder, Poria powder, for subsequent use;
2) crude drug Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi are mixed after Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi mixed material, add water, mixed material is carried out to heating extraction, collect extracting solution;
3) extracting solution is carried out to concentration, make the concentrated extract of Rhizoma Polygonati, Radix Rehmanniae and Radix Asparagi;
4) crude drug Poria powder and Mel are joined to concentrated extract and mix, crushed after being dried, makes dry extract powder;
5) Radix Ginseng powder is joined in dry extract powder, mix homogeneously, to obtain final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104666823A (en) * | 2015-03-13 | 2015-06-03 | 正大青春宝药业有限公司 | Medicinal composition capable of adjusting immunity and delaying senescence, and preparation method for medicinal composition |
| CN112137088A (en) * | 2020-09-24 | 2020-12-29 | 琛蓝(美国)营养制品股份有限公司 | Compound composition with antioxidant and anti-aging effects and preparation method and application thereof |
| CN113197270A (en) * | 2021-06-10 | 2021-08-03 | 周国尧 | Herbal beverage prepared from three materials and preparation method thereof |
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| CN1424021A (en) * | 2001-12-13 | 2003-06-18 | 孙家盛 | Skin pomade |
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| CN1424021A (en) * | 2001-12-13 | 2003-06-18 | 孙家盛 | Skin pomade |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104666823A (en) * | 2015-03-13 | 2015-06-03 | 正大青春宝药业有限公司 | Medicinal composition capable of adjusting immunity and delaying senescence, and preparation method for medicinal composition |
| CN112137088A (en) * | 2020-09-24 | 2020-12-29 | 琛蓝(美国)营养制品股份有限公司 | Compound composition with antioxidant and anti-aging effects and preparation method and application thereof |
| CN113197270A (en) * | 2021-06-10 | 2021-08-03 | 周国尧 | Herbal beverage prepared from three materials and preparation method thereof |
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