CN105213574A - A kind of Chinese medicine composition for the treatment of myocardial infarction and preparation method thereof - Google Patents
A kind of Chinese medicine composition for the treatment of myocardial infarction and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition for the treatment of myocardial infarction and preparation method thereof.This Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 12-20 part, Radix Cudraniae 3-10 part, Fructus Arctii 6-12 part, Fructus Aurantii Immaturus 6-10 part, Radix Notoginseng 10-15 part, Fructus Toosendan 3-10 part, Fructus Foeniculi 8-15 part, Fructus Crataegi 10-15 part, Fructus Corni 3-10 part, Cortex Cinnamomi 3-10 part, Radix Aconiti Lateralis Preparata 3-10 part, Herba Leonuri 3-10 part.Chinese medicine composition provided by the invention is based on blood circulation promoting and blood stasis dispelling and invigorating the spleen and replenishing QI, and promoting the circulation of QI to relieve pain are auxiliary, have significant curative effect to myocardial infarction, and its side effect is low, taking convenience and be easy to apply.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of myocardial infarction and preparation method thereof.
Background technology
Myocardial infarction (having another name called myocardial infarction) is coronary occlusion, blood flow ceases, makes part cardiac muscle, because of serious persistency ischemia, local necrosis occur.Have acutely and comparatively lasting retrosternal pain clinically, heating, leukocytosis, erythrocyte sedimentation rate are accelerated, and serum cardiac enzyme activity increases and Progressive symmetric erythrokeratodermia ECG Change, and arrhythmia, shock or heart failure can occur.Patient is mostly occurred on coronary atherosclerosis basis, because some inducement causes Atherosclerotic Vessels: Changes Observed during Coronary to break, the platelet in blood is assembled in the plaque surface of breaking, and forms clot (thrombosis), unexpected blocked coronary arteries tube chamber, causes myocardial ischemia and necrosis.
Experiment proves: Herba Leonuri has the effect significantly increasing coronary flow and decreased heart rate quite significantly. Herba Leonuri 1ml/kg is to anesthetized dog intravenous injection, there is increase coronary flow, reduce coronary resistance, decreased heart rate and reduce the effect of cardiac output and the work done of left room. Herba Leonuri all has antagonism in various degree to animal models such as expeirmental myocardial ischemia, myocardial infarction or arrhythmia.Herba Leonuri and extract thereof have antagonism to intact animal's platelet aggregation that ADP induces. also significantly can reduce platelet and aggregation thereof in total number of blood platelet in peripheral circulation and alveolar wall blood capillary. and the platelet aggregation activity caused to be scalded to the swimming of rat frozen water or large area and increases and also have remarkable inhibitory action. Herba Leonuri decoct can make thrombosis time lengthening to rat oral gavage, contraction in length, weight saving, also platelet count can be made to reduce, aggregation capability weakens, prothrombin time and KPTT shorten and plasma fibrinogen reduces, euglobulin lysis time shortens, therefore prove that Herba Leonuri has certain therapeutical effect to myocardial infarction.
China Patent No. 201410574460.5 discloses a kind of Chinese medicine composition for the treatment of myocardial infarction, and its raw materials comprises; Stigma Croci, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Rubra, Poria, Rhizoma Acori Graminei, Radix Polygalae, Herba Leonuri, the Radix Astragali, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Cibotii.It has good effect to myocardial infarction, but the effect of its aspect such as boosting qi and nourishing yin, blood circulation promoting and blood stasis dispelling is not very remarkable.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of myocardial infarction, this Chinese medicine composition has effect of blood circulation promoting and blood stasis dispelling and invigorating the spleen and replenishing QI, also have that good effect, side effect are low, taking convenience and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight: Caulis Spatholobi 12-20 part, Radix Cudraniae 3-10 part, Fructus Arctii 6-12 part, Fructus Aurantii Immaturus 6-10 part, Radix Notoginseng 10-15 part, Fructus Toosendan 3-10 part, Fructus Foeniculi 8-15 part, Fructus Crataegi 10-15 part, Fructus Corni 3-10 part, Cortex Cinnamomi 3-10 part, Radix Aconiti Lateralis Preparata 3-10 part, Herba Leonuri 3-10 part.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 12 parts, Radix Cudraniae 3 parts, Fructus Arctii 6 parts, Fructus Aurantii Immaturus 6 parts, Radix Notoginseng 10 parts, Fructus Toosendan 3 parts, 8 parts, Fructus Foeniculi, Fructus Crataegi 10 parts, Fructus Corni 3 parts, Cortex Cinnamomi 3 parts, Radix Aconiti Lateralis Preparata 3 parts, Herba Leonuri 3 parts.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 20 parts, Radix Cudraniae 10 parts, Fructus Arctii 12 parts, Fructus Aurantii Immaturus 10 parts, Radix Notoginseng 15 parts, Fructus Toosendan 10 parts, 15 parts, Fructus Foeniculi, Fructus Crataegi 15 parts, Fructus Corni 10 parts, Cortex Cinnamomi 10 parts, Radix Aconiti Lateralis Preparata 10 parts, Herba Leonuri 10 parts.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 16 parts, Radix Cudraniae 6 parts, Fructus Arctii 9 parts, Fructus Aurantii Immaturus 8 parts, Radix Notoginseng 12 parts, Fructus Toosendan 6 parts, 10 parts, Fructus Foeniculi, Fructus Crataegi 12 parts, Fructus Corni 6 parts, Cortex Cinnamomi 6 parts, Radix Aconiti Lateralis Preparata 6 parts, Herba Leonuri 6 parts.
Preferably, described Chinese medicine composition is made into tablet, capsule, drop pill, granule or powder.
Accordingly, the preparation method of Chinese medicine composition provided by the invention comprises following step:
1) Caulis Spatholobi is taken, pulverize, adding medical material weight 2-7 times amount volume fraction is the alcoholic solution of 60-90%, add the cellulase of medical material weight 0.6-1.5% again, lixiviate 2-3 hour at 36-50 DEG C, then at 80-95 DEG C of reflux, extract, 1-3 hour, filter and retain Caulis Spatholobi filtering residue, obtaining Caulis Spatholobi extracting solution;
2) take Herba Leonuri, the impurity such as removing undesirable root, thick stalk, clean, with the soak by water of 85-100 DEG C after pulverizing; Filter, obtain Herba Leonuri decocting medicinal liquid;
3) Radix Cudraniae, Fructus Arctii, Fructus Aurantii Immaturus, Radix Notoginseng, Fructus Toosendan, Fructus Foeniculi, Fructus Crataegi, Fructus Corni, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata is taken, add described Caulis Spatholobi filtering residue, pulverize, add 2-6 times amount heavy water and boil 2-5 hour, filter, obtain filtrate, the volume fraction adding 3-5 times of weight in filtering residue is the alcoholic solution of 60-90%, boils 35-80 minute, filters, obtain filtrate, merge twice filtrate;
4) described Caulis Spatholobi extracting solution, described Herba Leonuri decocting medicinal liquid and described twice filtrate are mixed, be concentrated into the thick paste that relative density is 1.10-1.35, drying under reduced pressure, cross 100-200 mesh sieve after pulverizing, obtain Chinese medicine composition of the present invention.
Source, the nature and flavor of the present invention's component used, return through and effect.
Caulis Spatholobi: this product is the dry rattan of leguminous plant spatholobus suberectus; Bitter in the mouth, sweet, warm in nature; Return liver, kidney channel; Have and enrich blood, invigorate blood circulation, the effects such as dredging collateral.
Fructus Arctii: this product is Compositae draft taproot class plant; Taste is cool, sweet, warm in nature; There is heat-clearing and toxic substances removing, the effects such as reducing swelling and alleviating pain.
Radix Notoginseng: this product is the dry root welding technology of panax araliaceae plant, sweet and slightly bitter taste is warm in nature; There is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.
Fructus Foeniculi: this product is the dry mature fruit of samphire Fructus Foeniculi; Warm in nature, acrid in the mouth; Return liver,kidney,spleen, stomach warp; There is warming the liver kidney, warming the stomach gas, loose plug knot, dispersing cold for relieving pain, the effects such as regulating qi-flowing for harmonizing stomach.
Fructus Crataegi: this product is Fructus Crataegi mature fruit; Nature and flavor acid is sweet, tepor; Enter spleen, stomach, Liver Channel; There is the effects such as spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting.
Fructus Corni: this product is Cornaceae machaka or dungarunga mature fruit; Nature and flavor are sour, puckery, tepor; Return liver, kidney channel; There is liver and kidney tonifying, the effects such as essence astringing and desertion stemming.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi; Acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel; There is benefit fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, the effects such as promoting blood circulation to restore menstrual flow.
Radix Aconiti Lateralis Preparata: this product is the processed goods of daughter root of Ranunculaceae, aconitum plant; There is recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, the effects such as dispersing cold for relieving pain.
Radix Cudraniae: this product is the root of little Zhe Shu or Zhe Shu of moraceae plants; Lightly seasoned micro-hardship, cool, there is invigorating spleen and reinforcing stomach, relaxing muscles and tendons and activating QI and blood in the collateral, wind-damp dispelling, blood stasis removing blood, the effects such as cool the blood dissipate blood stasis.
Fructus Aurantii Immaturus: this product is rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Citrus aurantium Linn. or fragrant round young fruit; Nature and flavor are bitter, cold, have the effects such as the pain in chest and hypochondrium for the treatment of QI and blood retardance.
Herba Leonuri: this product is the fresh of labiate Herba Leonuri or dry aerial parts; Bitter in the mouth, pungent, be slightly cold, return Liver Channel, pericardium channel; Have heart tonifying, increase the effect of coronary flow and myocardial alimentary blood flow, to platelet aggregation, platelet thrombosis, fibrinous thrombus is formed and erythrocytic aggregation all has inhibitory action.
Fructus Toosendan: this product is the mature fruit of Meliaceae deciduous tree toosendanin, the sedimentation of Fructus Toosendan bitter cold, mainly enters Liver Channel, has catharsis liver-heat, the effects such as promoting the circulation of QI to relieve pain.
Compared with prior art, the present invention has following beneficial effect:
Prescription of the present invention has method, and compatibility has system, i.e. honor ancient books but also have the method for innovation.Myocardial infarction is coronary occlusion, blood flow ceases, make part cardiac muscle, because of serious persistency ischemia, local necrosis occur, therefore Caulis Spatholobi, Fructus Crataegi, Cortex Cinnamomi, Radix Cudraniae is used, promoting blood circulation to remove obstruction in the collateral, blood stasis dispelling of enriching blood, make QI and blood unobstructed, by Radix Notoginseng, Herba Leonuri hemostasis tying-in, with Fructus Foeniculi, Fructus Corni, Radix Aconiti Lateralis Preparata, Fructus Aurantii Immaturus, Fructus Toosendan promoting the circulation of QI to relieve pain, invigorating the spleen and replenishing QI.With blood circulation promoting and blood stasis dispelling, soothing the channels and quicking the network vessels is for treating originally, promoting the circulation of QI to relieve pain, invigorating the spleen and replenishing QI is real, specimen brings out the best in each other, all medicines complement each other, play benefiting QI for activating blood circulation altogether, the effect that heart tonifying is promoted blood circulation, compared with the Chinese medicine of existing other treatment myocardial infarction, the present invention treats myocardial infarction significant curative effect, compared with chemotherapeutic agent, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction significantly reduces, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, myocardial infarction disease is treated from root, there is good effect, taking convenience and be easy to advantages such as applying.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1
Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight: Caulis Spatholobi 12 parts, Radix Cudraniae 3 parts, Fructus Arctii 6 parts, Fructus Aurantii Immaturus 6 parts, Radix Notoginseng 10 parts, Fructus Toosendan 3 parts, 8 parts, Fructus Foeniculi, Fructus Crataegi 10 parts, Fructus Corni 3 parts, Cortex Cinnamomi 3 parts, Radix Aconiti Lateralis Preparata 3 parts, Herba Leonuri 3 parts.
Preparation method comprises following step:
1) take Caulis Spatholobi, pulverize, adding medical material weight 2 times amount volume fraction is the alcoholic solution of 60%, add the cellulase of medical material weight 0.6% again, lixiviate 2 hours at 36 DEG C, then 80 DEG C of reflux, extract, 1 hour, filter and retain Caulis Spatholobi filtering residue, obtaining Caulis Spatholobi extracting solution;
2) take Herba Leonuri, the impurity such as removing undesirable root, thick stalk, clean, with the soak by water of 85 DEG C after pulverizing; Filter, obtain Herba Leonuri decocting medicinal liquid;
3 take Radix Cudraniae, Fructus Arctii, Fructus Aurantii Immaturus, Radix Notoginseng, Fructus Toosendan, Fructus Foeniculi, Fructus Crataegi, Fructus Corni, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata respectively, add described Caulis Spatholobi filtering residue, pulverize, add 2 times amount heavy water and boil 2 hours, filter, obtain filtrate, the volume fraction adding 3 times of weight in filtering residue is the alcoholic solution of 60%, boils 35 minutes, filters, obtain filtrate, merge twice filtrate;
4) described Caulis Spatholobi extracting solution, described Herba Leonuri decocting medicinal liquid and described twice filtrate are mixed, be concentrated into the thick paste that relative density is 1.10, drying under reduced pressure, cross 100 mesh sieves after pulverizing, obtain Chinese medicine composition of the present invention.Add starch, water and rubber cement, mixing, stirs, is pressed into thin slice, be ground into granule, obtain the embodiment of the present invention 1 Chinese medicinal composition granules.
embodiment 2:
Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight: Caulis Spatholobi 20 parts, Radix Cudraniae 10 parts, Fructus Arctii 12 parts, Fructus Aurantii Immaturus 10 parts, Radix Notoginseng 15 parts, Fructus Toosendan 10 parts, 15 parts, Fructus Foeniculi, Fructus Crataegi 15 parts, Fructus Corni 10 parts, Cortex Cinnamomi 10 parts, Radix Aconiti Lateralis Preparata 10 parts, Herba Leonuri 10 parts.
Preparation method comprises following step:
1) take Caulis Spatholobi, pulverize, adding medical material weight 7 times amount volume fraction is the alcoholic solution of 90%, add the cellulase of medical material weight 1.5% again, lixiviate 3 hours at 45 DEG C, then 85 DEG C of reflux, extract, 3 hours, filter and retain Caulis Spatholobi filtering residue, obtaining Caulis Spatholobi extracting solution;
2) take Herba Leonuri, the impurity such as removing undesirable root, thick stalk, clean, with the soak by water of 100 DEG C after pulverizing; Filter, obtain Herba Leonuri decocting medicinal liquid;
3) Radix Cudraniae, Fructus Arctii, Fructus Aurantii Immaturus, Radix Notoginseng, Fructus Toosendan, Fructus Foeniculi, Fructus Crataegi, Fructus Corni, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata is taken respectively, add described Caulis Spatholobi filtering residue, pulverize, add 2 times amount heavy water and boil 4 hours, filter, obtain filtrate, the volume fraction adding 5 times of weight in filtering residue is the alcoholic solution of 90%, boils 60 minutes, filters, obtain filtrate, merge twice filtrate;
4) described Caulis Spatholobi extracting solution, described Herba Leonuri decocting medicinal liquid and described twice filtrate are mixed, be concentrated into the thick paste that relative density is 1.30, drying under reduced pressure, cross 200 mesh sieves after pulverizing, obtain Chinese medicine composition of the present invention.Add starch, water and rubber cement, mixing, stirs, is pressed into thin slice, be ground into granule, obtain the embodiment of the present invention 2 Chinese medicinal composition granules.
embodiment 3:
Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight: Caulis Spatholobi 16 parts, Radix Cudraniae 6 parts, Fructus Arctii 9 parts, Fructus Aurantii Immaturus 8 parts, Radix Notoginseng 12 parts, Fructus Toosendan 6 parts, 10 parts, Fructus Foeniculi, Fructus Crataegi 12 parts, Fructus Corni 6 parts, Cortex Cinnamomi 6 parts, Radix Aconiti Lateralis Preparata 6 parts, Herba Leonuri 6 parts.
Preparation method comprises following step:
1) take Caulis Spatholobi, pulverize, adding medical material weight 5 times amount volume fraction is the alcoholic solution of 75%, add the cellulase of medical material weight 1.0% again, lixiviate 2 hours at 45 DEG C, then 85 DEG C of reflux, extract, 2 hours, filter and retain Caulis Spatholobi filtering residue, obtaining Caulis Spatholobi extracting solution;
2) take Herba Leonuri, the impurity such as removing undesirable root, thick stalk, clean, with the soak by water of 90 DEG C after pulverizing; Filter, obtain Herba Leonuri decocting medicinal liquid;
3) Radix Cudraniae, Fructus Arctii, Fructus Aurantii Immaturus, Radix Notoginseng, Fructus Toosendan, Fructus Foeniculi, Fructus Crataegi, Fructus Corni, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata is taken respectively, add described Caulis Spatholobi filtering residue, pulverize, add 4 times amount heavy water and boil 3 hours, filter, obtain filtrate, the volume fraction adding 4 times of weight in filtering residue is the alcoholic solution of 75%, boils 45 minutes, filters, obtain filtrate, merge twice filtrate;
4) described Caulis Spatholobi extracting solution, described Herba Leonuri decocting medicinal liquid and described twice filtrate are mixed, be concentrated into the thick paste that relative density is 1.20, drying under reduced pressure, cross 200 mesh sieves after pulverizing, obtain Chinese medicine composition of the present invention.Add starch, water and rubber cement, mixing, stirs, is pressed into thin slice, be ground into granule, obtain the embodiment of the present invention 3 Chinese medicinal composition granules.
clinical observation on the therapeutic effect
1, case selection: in 400 routine myocardial infarction clinical patients volunteers, male 200 example, female patient 200 example, age bracket be 45-60 year, all patients all has typical myocardial infarction clinical symptoms, and in sex, age, the course of disease no difference of science of statistics.
2, diagnostic criteria:
(1) typical myocardial ischemia symptom (chest pain or discomfort uncomfortable in chest);
(2) typical cardiac electrical figure change;
(3) Serum fibrosis markers raises.
3, efficacy assessment standard:
Cure: after drug administration, malaise symptoms disappears completely;
Effective: after drug administration, malaise symptoms alleviates or partial disappearance;
Invalid: after drug administration, malaise symptoms is unchanged;
Total effective rate=(cure+effectively)/total number of cases × 100%.
4, instructions of taking: 400 patient volunteers are divided into 4 groups at random, often organize 100 people, be respectively treatment A group, treatment B group, treatment C group and positive controls, treatment A group, treatment B group, treatment component C do not take the Chinese medicine composition that the embodiment of the present invention 1,2,3 prepares, every day 3 times, each 10-20g, serve on 1 month.Positive controls takes FUFANG DANSHEN DIWAN (Tianjin Tasly Pharmaceutical Co., Ltd, the accurate word Z10950111 of traditional Chinese medicines), and oral or sublingual administration, 10 balls, 3 times on the one, serve on 1 month.
5, therapeutic outcome: as shown in table 1.
table 1 therapeutic outcome
| Group | Number | Cure | Effectively | Invalid | Total effective rate |
| Treatment A group | 100 | 83 | 6 | 11 | 89％ |
| Treatment B group | 100 | 85 | 5 | 10 | 90％ |
| Treatment C group | 100 | 89 | 4 | 7 | 93% |
| Positive controls | 100 | 70 | 12 | 18 | 82％ |
Compared by the therapeutic effect of Chinese medicine composition of the present invention and FUFANG DANSHEN DIWAN, the significant curative effect of traditional Chinese medicine composition for treating myocardial infarction aspect of the present invention can be found out.The cure rate of Chinese medicine composition of the present invention reaches more than 80%, total effective rate reaches more than 90%, higher than cure rate and the total effective rate of positive controls, wherein best with the therapeutic effect for the treatment of C group, visible, the good effect of Chinese medicine composition of the present invention, cure rate is high, can be used as the medicine for the treatment of myocardial infarction.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (6)
1. treat the Chinese medicine composition of myocardial infarction for one kind, it is characterized in that, be prepared from by the raw material of following parts by weight: Caulis Spatholobi 12-20 part, Radix Cudraniae 3-10 part, Fructus Arctii 6-12 part, Fructus Aurantii Immaturus 6-10 part, Radix Notoginseng 10-15 part, Fructus Toosendan 3-10 part, Fructus Foeniculi 8-15 part, Fructus Crataegi 10-15 part, Fructus Corni 3-10 part, Cortex Cinnamomi 3-10 part, Radix Aconiti Lateralis Preparata 3-10 part, Herba Leonuri 3-10 part.
2. the Chinese medicine composition for the treatment of myocardial infarction as claimed in claim 1, it is characterized in that, be prepared from by the raw material of following parts by weight: Caulis Spatholobi 12 parts, Radix Cudraniae 3 parts, Fructus Arctii 6 parts, Fructus Aurantii Immaturus 6 parts, Radix Notoginseng 10 parts, Fructus Toosendan 3 parts, 8 parts, Fructus Foeniculi, Fructus Crataegi 10 parts, Fructus Corni 3 parts, Cortex Cinnamomi 3 parts, Radix Aconiti Lateralis Preparata 3 parts, Herba Leonuri 3 parts.
3. the Chinese medicine composition for the treatment of myocardial infarction as claimed in claim 1, it is characterized in that, be prepared from by the raw material of following parts by weight: Caulis Spatholobi 20 parts, Radix Cudraniae 10 parts, Fructus Arctii 12 parts, Fructus Aurantii Immaturus 10 parts, Radix Notoginseng 15 parts, Fructus Toosendan 10 parts, 15 parts, Fructus Foeniculi, Fructus Crataegi 15 parts, Fructus Corni 10 parts, Cortex Cinnamomi 10 parts, Radix Aconiti Lateralis Preparata 10 parts, Herba Leonuri 10 parts.
4. the Chinese medicine composition for the treatment of myocardial infarction as claimed in claim 1, it is characterized in that, be prepared from by the raw material of following parts by weight: Caulis Spatholobi 16 parts, Radix Cudraniae 6 parts, Fructus Arctii 9 parts, Fructus Aurantii Immaturus 8 parts, Radix Notoginseng 12 parts, Fructus Toosendan 6 parts, 10 parts, Fructus Foeniculi, Fructus Crataegi 12 parts, Fructus Corni 6 parts, Cortex Cinnamomi 6 parts, Radix Aconiti Lateralis Preparata 6 parts, Herba Leonuri 6 parts.
5. the Chinese medicine composition of the treatment myocardial infarction as described in any one of claim 1-4, is characterized in that, described Chinese medicine composition is made into tablet, capsule, drop pill, granule or powder.
6. the preparation method of the Chinese medicine composition of the treatment myocardial infarction as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises following step:
1) Caulis Spatholobi is taken, pulverize, adding medical material weight 2-7 times amount volume fraction is the alcoholic solution of 60-90%, add the cellulase of medical material weight 0.6-1.5% again, lixiviate 2-3 hour at 36-50 DEG C, then at 80-95 DEG C of reflux, extract, 1-3 hour, filter and retain Caulis Spatholobi filtering residue, obtaining Caulis Spatholobi extracting solution;
2) take Herba Leonuri, the impurity such as removing undesirable root, thick stalk, clean, with the soak by water of 85-100 DEG C after pulverizing; Filter, obtain Herba Leonuri decocting medicinal liquid;
3) Radix Cudraniae, Fructus Arctii, Fructus Aurantii Immaturus, Radix Notoginseng, Fructus Toosendan, Fructus Foeniculi, Fructus Crataegi, Fructus Corni, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata is taken, add described Caulis Spatholobi filtering residue, pulverize, add 2-6 times amount heavy water and boil 2-5 hour, filter, obtain filtrate, the volume fraction adding 3-5 times of weight in filtering residue is the alcoholic solution of 60-90%, boils 35-80 minute, filters, obtain filtrate, merge twice filtrate;
4) described Caulis Spatholobi extracting solution, described Herba Leonuri decocting medicinal liquid and described twice filtrate are mixed, be concentrated into the thick paste that relative density is 1.10-1.35, drying under reduced pressure, cross 100-200 mesh sieve after pulverizing, obtain Chinese medicine composition of the present invention.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213769A (en) * | 2015-09-29 | 2016-01-06 | 罗奕珺 | A kind of Chinese medicine composition for the treatment of myocardial infarction and preparation method thereof |
| KR20190142657A (en) | 2018-06-18 | 2019-12-27 | 숙명여자대학교산학협력단 | Composition for neuroprotection containing extract or fraction of Maclura pubescens as an effective component |
| CN111467422A (en) * | 2020-04-29 | 2020-07-31 | 佛山科学技术学院 | Traditional Chinese medicine composition for treating myocardial infarction, pharmaceutical preparation and preparation method thereof |
| CN113197943A (en) * | 2021-03-21 | 2021-08-03 | 曾山平 | Rehabilitation wine for myocardial infarction and preparation method thereof |
-
2015
- 2015-11-09 CN CN201510754211.9A patent/CN105213574A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213769A (en) * | 2015-09-29 | 2016-01-06 | 罗奕珺 | A kind of Chinese medicine composition for the treatment of myocardial infarction and preparation method thereof |
| KR20190142657A (en) | 2018-06-18 | 2019-12-27 | 숙명여자대학교산학협력단 | Composition for neuroprotection containing extract or fraction of Maclura pubescens as an effective component |
| CN111467422A (en) * | 2020-04-29 | 2020-07-31 | 佛山科学技术学院 | Traditional Chinese medicine composition for treating myocardial infarction, pharmaceutical preparation and preparation method thereof |
| CN113197943A (en) * | 2021-03-21 | 2021-08-03 | 曾山平 | Rehabilitation wine for myocardial infarction and preparation method thereof |
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Application publication date: 20160106 |
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