CN105267414A - Alopecia-stopping hair-growing traditional Chinese medicine combination and preparation method of oral solution preparation thereof - Google Patents
Alopecia-stopping hair-growing traditional Chinese medicine combination and preparation method of oral solution preparation thereof Download PDFInfo
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Abstract
The invention relates to an alopecia-stopping hair-growing traditional Chinese medicine combination, a preparation method of an oral solution preparation thereof and application thereof in the oral solutuon preparation. The traditional Chinese medicine combination is composed of, by mass, 20-60 parts of prepared rehmannia root, 30-55 parts of Chinese angelica root, 40-70 parts of Hangzhou white peony root, 30-50 parts of Szechuan lovage rhizome, 30-55 parts of pawpaw, 30-40 parts of Chinese dodder seed, 30-42 parts of peach kernel and 30-45 parts of black sesame. Completely natural pure Chinese medicinal herbs are used, so that the traditional Chinese medicine combination is free of side effect and low in cost. Cure rate of the oral solution preparation to alopecia is up to 78.3%, and effectual (including cure and effectiveness) rate is up to 90.7%. Compared with the prior art, the cure rate of the oral solution preparation to alopecia is increased by 20.3%, and the effectual (including cure and effectiveness) rate is increased by 18.3%.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specially the preparation method of alopecia-stopping, Chinese medicinal hair growing composition and oral liquid formulations thereof.
Background technology
Alopecia is a kind of common disease, if malpractice or not in time, hair can be caused to come off for a long time even all de-light, have a strong impact on the life of people, working and learning.
At present, the medicine of hair growth is more, can be divided into two large classes: one is Western medicine, although Western medicine successful in a short time, but expensive, need long-term taking to maintain curative effect, patient's economic pressures are large, and there is larger side effect; Two is Chinese medicine, although there is certain curative effect, is not very desirable.
Summary of the invention
In view of this, the object of the present invention is to provide a kind ofly to have no side effect, cheap, the alopecia-stopping of Be very effective, Chinese medicinal hair growing composition.
The present invention is solved the problems of the technologies described above by following technological means:
First the present invention discloses a kind of alopecia-stopping, Chinese medicinal hair growing composition, is made up of following content of component: Radix Rehmanniae Preparata 20-60 part, Radix Angelicae Sinensis 30-55 part, Radix Paeoniae Alba 40-70 part, Rhizoma Chuanxiong 30-45 part, Fructus Chaenomelis 30-55 part, Semen Cuscutae 30-40 part, Semen Persicae 30-42 part and Semen Sesami Nigrum 30-45 part.
Further, described alopecia-stopping, Chinese medicinal hair growing composition are made up of following content of component: 45 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 48 parts, Radix Paeoniae Alba 56 parts, Rhizoma Chuanxiong 36 parts, Fructus Chaenomelis 42 parts, Semen Cuscutae 35 parts, 35 parts, Semen Persicae and Semen Sesami Nigrum 39 parts.
Described Radix Rehmanniae Preparata also known as Radix Rehmanniae Preparata, for the tuber of scrophulariaceae rehmannia glutinosa plant forms through Processing methods.Its sweet in the mouth, warm in nature, there is effect that moist, beneficial essence of enriching blood fills out marrow.
The described root when being classified as umbelliferae angelica, sweet in the mouth is pungent, warm in nature.Radix Angelicae Sinensis have anti-hypoxia, conditioner body immunity function, anticancer, improve looks, enrich blood invigorate blood circulation, the effect such as antibacterial, arteriosclerosis.
Described Radix Paeoniae Alba has another name called the Radix Paeoniae Alba, beggar, Radix Paeoniae Alba, golden Radix Paeoniae, the large Radix Paeoniae Alba, Radix Paeoniae Alba, Radix Paeoniae Alba (parched), Radix Paeoniae Alba, Radix Paeoniae Alba (processed with vinegar), the burnt Radix Paeoniae Alba, Radix Paeoniae Alba charcoal etc., for the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae, containing paeoniflorin, paeonol, benzoic acid, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein.It is cool in nature, bitter in the mouth acid, has the effects such as easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receipts antiperspirant.
Described Rhizoma Chuanxiong bitter in the mouth is pungent, slightly numb feeling in the tongue, micro-Hui Tian, can coronary artery dilator, increase coronary artery blood flow, improve the blood oxygen of cardiac muscle and supply and reduce myocardium oxygen consumption; Expansion of cerebral vascular, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation; Reduce surface activity of blood platelet, suppress platelet aggregation, the formation of pre-preventing thrombosis; The effect of vitamin antagonist E shortage; Suppress multiple bacillus; Antihistaminic.
Described Fructus Chaenomelis is again Caulis et folium euphorbiae milii pears, iron pin pear, warm in nature, and sweet in the mouth acid, has effect of relaxing muscles and tendons and activating QI and blood in the collateral, stomach function regulating removing dampness.
Described Semen Cuscutae is the dry mature seed of convolvulus cuscuta plant, and sweet in the mouth is warm in nature, has effect of the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, solid tire stopping leak.
Described Semen Persicae another name Radix Fici Hirtae core, almond core, large Semen Persicae are the seed of rosaceous plant Fructus Persicae or Prunus davidiana, are one of conventional Chinese medicine, have blood stasis removing and clots absorbing, moisturize effect of laxation.
Described Semen Sesami Nigrum is the black seeds of Pedaliaceae sesame, containing nutritional labelings such as fat, protein, saccharide, VitAVitE, lecithin, calcium, ferrum, chromium.Its sweet in the mouth, property is put down, and has invigorating the liver and kidney, grows the five internal organs, effect that benefiting essence-blood, intestine moistening are dry.
The dosage form of alopecia-stopping of the present invention, Chinese medicinal hair growing composition is oral liquid.
In addition, the invention also discloses the preparation method of oral liquid formulations of described alopecia-stopping, Chinese medicinal hair growing composition, its concrete steps are:
The Fructus Chaenomelis of A. getting above-mentioned mass parts soaks 2-5 minute in water, and water consumption is dipped Fructus Chaenomelis face 2-4cm, dry, and Fructus Chaenomelis is cut into slices after removing chip by sieve, and length is 4-5cm, and width is 0.8-1.5cm, and thickness is 1-3mm;
B. the Radix Rehmanniae Preparata of above-mentioned mass parts, Radix Angelicae Sinensis and Radix Paeoniae Alba are pulverized, the length of each dose of prepared slices of Chinese crude drugs is no more than 4.5cm;
C. pulverize and sieve respectively after the Rhizoma Chuanxiong of above-mentioned mass parts and Semen Cuscutae being carried out sterilization treatment, then extracted by supercritical fluid extraction;
D. the Semen Persicae of steps A gained, step B gained, step C gained and above-mentioned mass parts, Semen Sesami Nigrum are soaked 1-2 days;
E. the handy vigorous fire of step D is decocted to the 2-3 minute that fully seethes with excitement, receive to slow fire, decoct 30-45 minute, cooled and filtered, get filtrate, in filtrate, add crystal sugar, the amount of the crystal sugar added is: the content of crystal sugar in filtrate is 45-50g/mL, obtains the oral liquid formulations of described alopecia-stopping, Chinese medicinal hair growing composition.
Described supercritical fluid extraction is called for short SFE.The method has following advantage: by means of regulated fluid temperature and pressure control flow check body density so that improve extracting power; Solvent recovery is simple and convenient, saves the energy; Comparatively fast can reach and balance each other.
Further, Co is passed through in sterilizing described in step C
60radiation realizes.Described radiation sterilizing power consumption is low, compared with traditional method, can save the energy several times to tens times; Ray penetration power is strong, can kill various packaging, the various microorganism of in bulk, solid, liquid surface and inside and insect; Irradiation processing belongs to cold working, can not cause the obvious increase of internal temperature, and it is again Physical Processing simultaneously, does not need to add any chemical agent, does not have pesticide residues, also radioactivity does not occur, free from environmental pollution.
Further, Co
60the dosage of radiation is 5-8kGy.The selection of radiation dose can produce material impact to the main component of bactericidal effect, Chinese medicine, performance, drug effect, and also not identical to the impact effect of different Chinese crude drugs.
Further, the optimum configurations of process of pulverizing and sieving described in step C is: the pulverizer of Semen Cuscutae installation 60 eye mesh screen is pulverized, material after pulverizing, cross the shaking screen of installation 60 mesh sieve, the Rhizoma Chuanxiong pulverizer of installation 45 eye mesh screen is pulverized, material after pulverizing, crosses the shaking screen of installation 45 mesh sieve, and whole pulverizing medicinal materials is until by regulation order number sieve net.Herein, these two kinds of traditional Chinese medicine powders are broken to appropriate particle size, be convenient to later use supercritical fluid extract, crushing material can be increased the contact area of material and supercritical fluid to appropriate particle size, rate of extraction can be made to significantly improve, but meticulous powder then can Severe blockage sieve aperture, causes frictional heat, bioactive substance is lost, and the blocking of extractor egress filtering net can be caused.
Further, Supercritical Extraction Process described in step C optimum configurations by: used gas for CO
2, pressure is 15-18MPa, and temperature is 28-32 DEG C.Extracting pressure, temperature, extract granular size are the principal elements affecting supercritical fluid extraction.Under the condition that extraction temperature is certain, pressure increases, and fluid density increases, and the dissolubility of solute increases.For different material, its extracting pressure also has very big difference.Under pressure certain condition, the volatility of raised temperature extract increases, and adds the concentration of extract in SF gas phase, thus extraction quantity is increased; On the other hand, temperature raises, and SF density reduces, and its solvability declines, and causes the minimizing extracting quantity.
Further, decoction process container used described in immersion process described in step D and step e is terrine, marmite or enamel ware.Should not use iron pan, aluminum pot so as not to Chinese medicine generation chemical reaction, drug effect is had an impact.
Further, the water that decoction process described in immersion process described in step D and step e is used is cold water, well water or spring water.Because cold water generally boils rear cooling by tap water, and tap water is through bleaching powder process, containing a large amount of chlorine elements, if directly use tap water, can impact the medicament of Chinese medicine.Also can direct well water or spring water, effect is better.
The invention has the beneficial effects as follows:
The alopecia-stopping of the application, Chinese medicinal hair growing composition use natural pure Chinese medicine completely, have no side effect, cheap.The alopecia-stopping of the application, the oral liquid formulations of Chinese medicinal hair growing composition are to the recovery from illness ratio of alopecia up to 78.3%, and effective (comprising recovery from illness with effective), ratio was up to 90.7%.Compared with prior art, the alopecia-stopping of the application, the recovery from illness ratio of the oral liquid formulations of Chinese medicinal hair growing composition to alopecia improve 20.3%; Effective (comprising recovery from illness with effective), ratio improve 18.3%.
Detailed description of the invention
Embodiment 1
Alopecia-stopping, Chinese medicinal hair growing composition, composed of the following components: Radix Rehmanniae Preparata 60g, Radix Angelicae Sinensis 30g, Radix Paeoniae Alba 40g, Rhizoma Chuanxiong 45g, Fructus Chaenomelis 30g, Semen Cuscutae 40g, Semen Persicae 30g and Semen Sesami Nigrum 45g.
The preparation method of described alopecia-stopping, the oral liquid formulations of Chinese medicinal hair growing composition is:
The Fructus Chaenomelis of A. getting above-mentioned mass parts soaks 2 minutes in water, and water consumption is dipped Fructus Chaenomelis face 4cm, dry, and Fructus Chaenomelis is cut into slices after removing chip by sieve, and length is 4cm, and width is 1.5cm, and thickness is 1mm;
B. the Radix Rehmanniae Preparata of above-mentioned mass parts, Radix Angelicae Sinensis and Radix Paeoniae Alba are pulverized, the length of each dose of prepared slices of Chinese crude drugs is no more than 4.5cm;
C. be the Co of 5kGy by the Rhizoma Chuanxiong of above-mentioned mass parts and Semen Cuscutae by dosage
60radiation pulverizes and sieves after carrying out sterilization treatment respectively, wherein, the Semen Cuscutae pulverizer of installation 60 eye mesh screen is pulverized, material after pulverizing, cross the shaking screen of installation 60 mesh sieve, the Rhizoma Chuanxiong pulverizer of installation 45 eye mesh screen is pulverized, the material after pulverizing, cross the shaking screen of installation 45 mesh sieve, whole pulverizing medicinal materials is until by regulation order number sieve net; Extracted by supercritical fluid extraction again; The optimum configurations of Supercritical Extraction Process by: used gas for CO
2, pressure is 15MPa, and temperature is 32 DEG C;
D. the Semen Persicae of steps A gained, step B gained, step C gained and above-mentioned mass parts, Semen Sesami Nigrum are placed in marmite and soak 1 day;
E. the handy vigorous fire of step D is decocted to fully boiling 3 minutes, receive to slow fire, decoct 45 minutes, decocting container used is terrine, cooled and filtered, gets filtrate, in filtrate, add crystal sugar, the amount of the crystal sugar added is: the content of crystal sugar in filtrate is 45g/mL, obtains the oral liquid formulations of described alopecia-stopping, Chinese medicinal hair growing composition.
The water that described in immersion process described in step D and step e, decoction process is used is cold water.
Embodiment 2
Alopecia-stopping, Chinese medicinal hair growing composition, composed of the following components: Radix Rehmanniae Preparata 20g, Radix Angelicae Sinensis 55g, Radix Paeoniae Alba 70g, Rhizoma Chuanxiong 30g, Fructus Chaenomelis 55g, Semen Cuscutae 30g, Semen Persicae 42g and Semen Sesami Nigrum 30g.
The preparation method of described alopecia-stopping, the oral liquid formulations of Chinese medicinal hair growing composition is:
The Fructus Chaenomelis of A. getting above-mentioned mass parts soaks 5 minutes in water, and water consumption is dipped Fructus Chaenomelis face 2cm, dry, and Fructus Chaenomelis is cut into slices after removing chip by sieve, and length is 5cm, and width is 0.8cm, and thickness is 3mm;
B. the Radix Rehmanniae Preparata of above-mentioned mass parts, Radix Angelicae Sinensis and Radix Paeoniae Alba are pulverized, the length of each dose of prepared slices of Chinese crude drugs is no more than 4.5cm;
C. be the Co of 8kGy by the Rhizoma Chuanxiong of above-mentioned mass parts and Semen Cuscutae by dosage
60radiation pulverizes and sieves after carrying out sterilization treatment respectively, wherein, the Semen Cuscutae pulverizer of installation 60 eye mesh screen is pulverized, material after pulverizing, cross the shaking screen of installation 60 mesh sieve, the Rhizoma Chuanxiong pulverizer of installation 45 eye mesh screen is pulverized, the material after pulverizing, cross the shaking screen of installation 45 mesh sieve, whole pulverizing medicinal materials is until by regulation order number sieve net; Extracted by supercritical fluid extraction again; The optimum configurations of Supercritical Extraction Process by: used gas for CO
2, pressure is 18MPa, and temperature is 28 DEG C;
D. the Semen Persicae of steps A gained, step B gained, step C gained and above-mentioned mass parts, Semen Sesami Nigrum are placed in enamel ware and soak 2 days;
E. the handy vigorous fire of step D is decocted to fully seething with excitement 2 minutes, receive to slow fire, decoct 30 minutes, decocting container used is marmite, cooled and filtered, gets filtrate, in filtrate, add crystal sugar, the amount of the crystal sugar added is: the content of crystal sugar in filtrate is 50g/mL, obtains the oral liquid formulations of described alopecia-stopping, Chinese medicinal hair growing composition.
The water that described in immersion process described in step D and step e, decoction process is used is well water.
Embodiment 3
Alopecia-stopping, Chinese medicinal hair growing composition, composed of the following components: Radix Rehmanniae Preparata 45g, Radix Angelicae Sinensis 48g, Radix Paeoniae Alba 56g, Rhizoma Chuanxiong 36g, Fructus Chaenomelis 42g, Semen Cuscutae 35g, Semen Persicae 35g and Semen Sesami Nigrum 39g.
The preparation method of described alopecia-stopping, the oral liquid formulations of Chinese medicinal hair growing composition is:
The Fructus Chaenomelis of A. getting above-mentioned mass parts soaks 3 minutes in water, and water consumption is dipped Fructus Chaenomelis face 3cm, dry, and Fructus Chaenomelis is cut into slices after removing chip by sieve, and length is 4.5cm, and width is 1.2cm, and thickness is 2mm;
B. the Radix Rehmanniae Preparata of above-mentioned mass parts, Radix Angelicae Sinensis and Radix Paeoniae Alba are pulverized, the length of each dose of prepared slices of Chinese crude drugs is no more than 4.5cm;
C. be the Co of 7kGy by the Rhizoma Chuanxiong of above-mentioned mass parts and Semen Cuscutae by dosage
60radiation pulverizes and sieves after carrying out sterilization treatment respectively, wherein, the Semen Cuscutae pulverizer of installation 60 eye mesh screen is pulverized, material after pulverizing, cross the shaking screen of installation 60 mesh sieve, the Rhizoma Chuanxiong pulverizer of installation 45 eye mesh screen is pulverized, the material after pulverizing, cross the shaking screen of installation 45 mesh sieve, whole pulverizing medicinal materials is until by regulation order number sieve net; Extracted by supercritical fluid extraction again; The optimum configurations of Supercritical Extraction Process by: used gas for CO
2, pressure is 16MPa, and temperature is 30 DEG C;
D. the Semen Persicae of steps A gained, step B gained, step C gained and above-mentioned mass parts, Semen Sesami Nigrum are placed in marmite and soak 1 day;
E. the handy vigorous fire of step D is decocted to fully seething with excitement 2 minutes, receive to slow fire, decoct 36 minutes, decocting container used is enamel ware, cooled and filtered, gets filtrate, in filtrate, add crystal sugar, the amount of the crystal sugar added is: the content of crystal sugar in filtrate is 48g/mL, obtains the oral liquid formulations of described alopecia-stopping, Chinese medicinal hair growing composition.
The water that described in immersion process described in step D and step e, decoction process is used is spring water.
Embodiment 4
Alopecia-stopping, Chinese medicinal hair growing composition, composed of the following components: Radix Rehmanniae Preparata 35g, Radix Angelicae Sinensis 45g, Radix Paeoniae Alba 50g, Rhizoma Chuanxiong 42g, Fructus Chaenomelis 40g, Semen Cuscutae 35g and Semen Sesami Nigrum 37g.
The preparation method of described alopecia-stopping, the oral liquid formulations of Chinese medicinal hair growing composition is:
The Fructus Chaenomelis of A. getting above-mentioned mass parts soaks 3 minutes in water, and water consumption is dipped Fructus Chaenomelis face 3cm, dry, and Fructus Chaenomelis is cut into slices after removing chip by sieve, and length is 5cm, and width is 1.0cm, and thickness is 2mm;
B. the Radix Rehmanniae Preparata of above-mentioned mass parts, Radix Angelicae Sinensis and Radix Paeoniae Alba are pulverized, the length of each dose of prepared slices of Chinese crude drugs is no more than 4.5cm;
C. be the Co of 6kGy by the Rhizoma Chuanxiong of above-mentioned mass parts and Semen Cuscutae by dosage
60radiation pulverizes and sieves after carrying out sterilization treatment respectively, wherein, the Semen Cuscutae pulverizer of installation 60 eye mesh screen is pulverized, material after pulverizing, cross the shaking screen of installation 60 mesh sieve, the Rhizoma Chuanxiong pulverizer of installation 45 eye mesh screen is pulverized, the material after pulverizing, cross the shaking screen of installation 45 mesh sieve, whole pulverizing medicinal materials is until by regulation order number sieve net; Extracted by supercritical fluid extraction again; The optimum configurations of Supercritical Extraction Process by: used gas for CO
2, pressure is 17MPa, and temperature is 31 DEG C;
D. the Semen Sesami Nigrum of steps A gained, step B gained, step C gained and above-mentioned mass parts is placed in terrine and soaks 2 days;
E. the handy vigorous fire of step D is decocted to fully seething with excitement 3 minutes, receive to slow fire, decoct 43 minutes, decocting container used is marmite, cooled and filtered, gets filtrate, in filtrate, add crystal sugar, the amount of the crystal sugar added is: the content of crystal sugar in filtrate is 49g/mL, obtains the oral liquid formulations of described alopecia-stopping, Chinese medicinal hair growing composition.
The water that described in immersion process described in step D and step e, decoction process is used is well water.
Embodiment 5
Alopecia-stopping, Chinese medicinal hair growing composition, composed of the following components: Radix Rehmanniae Preparata 28g, Radix Angelicae Sinensis 52g, Radix Paeoniae Alba 65g, Rhizoma Chuanxiong 33g, Fructus Chaenomelis 37g, Semen Cuscutae 35g, Semen Persicae 34g and Semen Sesami Nigrum 38g.
The preparation method of described alopecia-stopping, the oral liquid formulations of Chinese medicinal hair growing composition is:
The Fructus Chaenomelis of A. getting above-mentioned mass parts soaks 4 minutes in water, and water consumption is dipped Fructus Chaenomelis face 3cm, dry, and Fructus Chaenomelis is cut into slices after removing chip by sieve, and length is 4-5cm, and width is 0.8-1.5cm, and thickness is 1-3mm;
B. the Radix Rehmanniae Preparata of above-mentioned mass parts, Radix Angelicae Sinensis and Radix Paeoniae Alba are pulverized, the length of each dose of prepared slices of Chinese crude drugs is no more than 4.5cm;
C. the Rhizoma Chuanxiong of steps A gained, step B gained, step C gained and above-mentioned mass parts, Semen Cuscutae, Semen Persicae, Semen Sesami Nigrum are placed in enamel ware and soak 1-2 days;
E. the handy vigorous fire of step D is decocted to fully seething with excitement 3 minutes, receive to slow fire, decoct 38 minutes, decocting container used is terrine, cooled and filtered, gets filtrate, in filtrate, add crystal sugar, the amount of the crystal sugar added is: the content of crystal sugar in filtrate is 46g/mL, obtains the oral liquid formulations of described alopecia-stopping, Chinese medicinal hair growing composition.
The water that described in immersion process described in step D and step e, decoction process is used is spring water.
Embodiment 6
With publication number for hair tonic tea for preventing and stopping alopecia described in CN101411370B and described method prepare hair tonic tea for preventing and stopping alopecia.
This hair tonic tea for preventing and stopping alopecia is composed of the following components: Folium Ilicis 50g, nine Radix Polygoni Multiflori Preparata 20g, Herba Ecliptae 10g, Radix Rehmanniae 10g, Radix Rehmanniae Preparata 10g, Radix Astragali 10g, Herba Menthae 20g, Semen Cuscutae 5g, Fructus Mori 20g, Fructus Ligustri Lucidi 5g, Radix Angelicae Sinensis 5g and Radix Salviae Miltiorrhizae 5g.
The preparation method of this hair tonic tea for preventing and stopping alopecia is:
A. by nine Radix Polygoni Multiflori Preparatas, Herba Ecliptae, the Radix Rehmanniae, Radix Rehmanniae Preparata, the Radix Astragali, Semen Cuscutae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae mixing, add 1kg water, infusion to seething with excitement latter 5 minutes, elimination residue, then with slow fire concentrated 30 minutes;
B. get concentrated medicament and soak Folium Ilicis 24 hours, system of then simmering is to dry;
C. the Folium Ilicis got after the system of stewing mixes with the Fructus Lycii after washing and sterilizing, Fructus Mori, Fructus Ligustri Lucidi, is ground into 100 order smalls;
D. carry out high-temperature maturing, sterilization treatment, obtain hair tonic tea for preventing and stopping alopecia.
Patient 258 example is accepted for medical treatment, male 133 example, women 125 example in surrounding area, place, inventor residence; Wherein, oldest 62 years old, minimum 29 years old of age.Patient is divided into six groups at random, takes the hair tonic tea for preventing and stopping alopecia that alopecia-stopping that embodiment 1-5 prepares, the oral liquid formulations of Chinese medicinal hair growing composition and embodiment 6 prepare respectively, daily three times, each 15g.Detect clinical effectiveness, result is as shown in the table:
Diagnosis and treatment evaluation criteria
Recovery from illness: alopecia transference cure, grow new sending out, and drug withdrawal has no recurrence half a year.
Effective: alopecia symptom alleviates, but does not take a turn for the better completely.
Invalid: alopecia symptom is without obvious change.
From above result, alopecia-stopping prepared by embodiment 1-3, the oral liquid formulations of Chinese medicinal hair growing composition are to the recovery from illness ratio of alopecia up to 78.3%, and effective (comprising recovery from illness with effective), ratio was up to 90.7%.Compared with the hair tonic tea for preventing and stopping alopecia prepared with embodiment 6, alopecia-stopping prepared by embodiment 1-3, the oral liquid formulations of the Chinese medicinal hair growing composition recovery from illness ratio to alopecia improves 20.3%; Effective (comprising recovery from illness with effective), ratio improve 18.3%.Prove thus, the therapeutic effect of oral liquid formulations to alopecia of alopecia-stopping of the present invention, Chinese medicinal hair growing composition is remarkable.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, those of ordinary skill in the art is to be understood that, can modify to technical scheme or equivalent replacement, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (10)
1. alopecia-stopping, Chinese medicinal hair growing composition, it is characterized in that, be made up of following content of component: Radix Rehmanniae Preparata 20-60 part, Radix Angelicae Sinensis 30-55 part, Radix Paeoniae Alba 40-70 part, Rhizoma Chuanxiong 30-45 part, Fructus Chaenomelis 30-55 part, Semen Cuscutae 30-40 part, Semen Persicae 30-42 part and Semen Sesami Nigrum 30-45 part.
2. alopecia-stopping according to claim 1, Chinese medicinal hair growing composition, it is characterized in that, be made up of following content of component: 45 parts, Radix Rehmanniae Preparata, Radix Angelicae Sinensis 48 parts, Radix Paeoniae Alba 56 parts, Rhizoma Chuanxiong 36 parts, Fructus Chaenomelis 42 parts, Semen Cuscutae 35 parts, 35 parts, Semen Persicae and Semen Sesami Nigrum 39 parts.
3. the alopecia-stopping described in claim 1 or 2, the preparation of Chinese medicinal hair growing composition, is characterized in that: the dosage form of described alopecia-stopping, Chinese medicinal hair growing composition is oral liquid.
4. the preparation of alopecia-stopping according to claim 3, Chinese medicinal hair growing composition, is characterized in that, the preparation method of the oral liquid formulations of described alopecia-stopping, Chinese medicinal hair growing composition is:
The Fructus Chaenomelis of A. getting above-mentioned mass parts soaks 2-5 minute in water, and water consumption is dipped Fructus Chaenomelis face 2-4cm, dry, and Fructus Chaenomelis is cut into slices after removing chip by sieve, and length is 4-5cm, and width is 0.8-1.5cm, and thickness is 1-3mm;
B. the Radix Rehmanniae Preparata of above-mentioned mass parts, Radix Angelicae Sinensis and Radix Paeoniae Alba are pulverized, the length of each dose of prepared slices of Chinese crude drugs is no more than 4.5cm;
C. pulverize and sieve respectively after the Rhizoma Chuanxiong of above-mentioned mass parts and Semen Cuscutae being carried out sterilization treatment, then extracted by supercritical fluid extraction;
D. the Semen Persicae of steps A gained, step B gained, step C gained and above-mentioned mass parts, Semen Sesami Nigrum are soaked 1-2 days;
E. the handy vigorous fire of step D is decocted to the 2-3 minute that fully seethes with excitement, receive to slow fire, decoct 30-45 minute, cooled and filtered, get filtrate, in filtrate, add crystal sugar, the amount of the crystal sugar added is: the content of crystal sugar in filtrate is 45-50g/mL, obtains the oral liquid formulations of described alopecia-stopping, Chinese medicinal hair growing composition.
5. the preparation of alopecia-stopping according to claim 4, Chinese medicinal hair growing composition, is characterized in that: Co is passed through in sterilizing described in step C
60radiation realizes.
6. the preparation of alopecia-stopping according to claim 5, Chinese medicinal hair growing composition, is characterized in that: Co
60the dosage of radiation is 5-8kGy.
7. the alopecia-stopping according to claims 4, the preparation of Chinese medicinal hair growing composition, it is characterized in that, the optimum configurations of process of pulverizing and sieving described in step C is: the pulverizer of Semen Cuscutae installation 60 eye mesh screen is pulverized, material after pulverizing, cross the shaking screen of installation 60 mesh sieve, the Rhizoma Chuanxiong pulverizer of installation 45 eye mesh screen is pulverized, the material after pulverizing, cross the shaking screen of installation 45 mesh sieve, whole pulverizing medicinal materials is until by regulation order number sieve net.
8. the preparation of alopecia-stopping according to claim 4, Chinese medicinal hair growing composition, is characterized in that, the optimum configurations of Supercritical Extraction Process described in step C by: used gas for CO
2, pressure is 15-18MPa, and temperature is 28-32 DEG C.
9. the preparation of alopecia-stopping according to claim 4, Chinese medicinal hair growing composition, is characterized in that: described in immersion process described in step D and step e, decoction process container used is terrine, marmite or enamel ware.
10. the preparation of alopecia-stopping according to claim 4, Chinese medicinal hair growing composition, is characterized in that: the water that described in immersion process described in step D and step e, decoction process is used is cold water, well water or spring water.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772626A (en) * | 2019-11-28 | 2020-02-11 | 佰氏健康(广州)大健康科技有限公司 | Alopecia stopping and hair growing liquid and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178779A (en) * | 2011-04-25 | 2011-09-14 | 悦康药业集团有限公司 | Method for preparing capsules containing prepared rehmannia root, white paeony root, Chinese angelica and szechuan lovage rhizome and application |
| CN102824616A (en) * | 2012-07-11 | 2012-12-19 | 杭州天诚药业有限公司 | Anti-hair loss and hair growing traditional Chinese medicine composition and preparation method thereof |
| CN102895401A (en) * | 2012-10-31 | 2013-01-30 | 王丽娟 | Germinal traditional Chinese medicine and preparation method thereof |
| CN104415108A (en) * | 2013-08-23 | 2015-03-18 | 李霞 | Medicine for preventing and treating alopecia |
-
2015
- 2015-10-30 CN CN201510719304.8A patent/CN105267414A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178779A (en) * | 2011-04-25 | 2011-09-14 | 悦康药业集团有限公司 | Method for preparing capsules containing prepared rehmannia root, white paeony root, Chinese angelica and szechuan lovage rhizome and application |
| CN102824616A (en) * | 2012-07-11 | 2012-12-19 | 杭州天诚药业有限公司 | Anti-hair loss and hair growing traditional Chinese medicine composition and preparation method thereof |
| CN102895401A (en) * | 2012-10-31 | 2013-01-30 | 王丽娟 | Germinal traditional Chinese medicine and preparation method thereof |
| CN104415108A (en) * | 2013-08-23 | 2015-03-18 | 李霞 | Medicine for preventing and treating alopecia |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772626A (en) * | 2019-11-28 | 2020-02-11 | 佰氏健康(广州)大健康科技有限公司 | Alopecia stopping and hair growing liquid and preparation method thereof |
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