CN101690764A - Traditional Chinese medicine for treating cardiac, cerebral and vascular diseases and preparation method thereof - Google Patents
Traditional Chinese medicine for treating cardiac, cerebral and vascular diseases and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating cardiac, cerebral and vascular diseases; the drug is composed of forty kinds of crude drugs by weight parts: milk veteh, salvia miltiorrhiza, root of common peony, ligusticum wallichii, lumbricus, sanguisuga, rhizoma acori graminei, polygala root, red ocher, oyster, angelica, the root of kudzu vine, arisaema cum bile and the like; the preparation method is that: (1) the crude drugs are prepared into water extract liquid; (2) the water extract liquid is prepared into oral liquid; (3)the water extract liquid obtained by the step (1) is dried, crushed, sieved, undersize material is extracted powder; (4) the extracted powder prepared by the step (3) is prepared into various dosage forms. The preparation method of crude powder is that: lime earth of the crude drugs is sieved, and then the crude drugs are crushed and sieved, the undersize material is taken out and is sterilized to be crude powder, and the crude powder is prepared into various dosage forms. The traditional Chinese medicine has the major functions of treating miocardial infarction and angina caused by coronary heart disease, high blood pressure and cerebral thrombosis, hemiplegia, cerebral infarction, cerebrovascular accident, sequel of apoplexy and other symptoms, and the medicine has obvious effect on headache, dizziness and heart cerebrovascular diseases caused by high blood pressure and cerebral circulation insufficiency.
Description
Technical field
The present invention relates to a kind of Chinese medicine and preparation method thereof, concrete is a kind of Chinese medicine for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof.
Background technology
Cardiovascular and cerebrovascular disease is meant cardiovascular and cerebrovascular vessel generation pathological changes and causes the disease of heart and brain tissues blood supply disorder.Wherein, cardiovascular disease mainly contains coronary heart disease and angina pectoris, and cerebrovascular disease is mainly hemorrhagic apoplexy and ischemic cerebrovascular.Cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction, hypertension, cerebral arteriosclerosis, cerebral thrombosis, cerebral infarction, cerebral thrombosis are commonly encountered diseases and frequently-occurring disease, this class disease incidence height, the disability rate height, the mortality rate height, also can cause the damage of organs such as the heart, brain, kidney, cause diseases such as brain sudden death, cardiac failure, renal failure, serious to endanger people healthy, is called as first killer of current society.Along with the raising of people's living standard, social population's aging, and the quickening of people's live and work rhythm, the sickness rate of cardiovascular and cerebrovascular disease has the trend that increases year by year, and the ill age is tending towards rejuvenation.Adopt this class disease of western medicine, side effect is big.Traditional traditional Chinese medical science adopts decoction for removing blood stasis, TONGQIAOHUOXUE Decoction, Wang Qingren BUYANG HUANWU TANG etc. usually to this class disease, but curative effect is undesirable.
Summary of the invention:
The objective of the invention is to for overcoming the deficiencies in the prior art Chinese medicine preparation of the treatment cardiovascular and cerebrovascular disease that propose a kind of stable curative effect, has no side effect and preparation method thereof.
Technical scheme of the present invention is that a kind of Chinese medicine for the treatment of cardiovascular and cerebrovascular disease is the medicament of being made by following weight parts proportion raw material medical material:
Radix Astragali 30-120 Radix Salviae Miltiorrhizae 10-60 Radix Paeoniae Rubra 10-30 Rhizoma Chuanxiong 10-30
Pheretima 10-90 Hirudo 5-15 Rhizoma Acori Graminei 10-60 Radix Polygalae 10-30
Haematitum 5-60 Concha Ostreae 5-30 Radix Angelicae Sinensis 5-30 Radix Puerariae 10-60
Arisaema Cum Bile 5-30 Caulis Spatholobi 10-90 Scorpio 0.3-15 Fructus Trichosanthis 10-60
Radix Saposhnikoviae 5-30 Bombyx Batryticatus 5-30 Ramulus Cinnamomi 3-15 Herba Erigerontis 0.1-15
Radix Platycodonis 3-15 Fructus Aurantii 3-15 Fructus Crataegi 5-60 Radix Rubiae 3-60
Poria 10-120 Herba Agrimoniae 5-90 Fructus Liquidambaris 3-30 Semen Persicae 0.1-15
Flos Carthami 0.1-15 Pollen Typhae 0.1-15 Ganoderma 3-30 Radix Achyranthis Bidentatae 6-30
Radix Notoginseng 3-60 Herba Siegesbeckiae 3-30 Folium Ginkgo 3-30 Radix Polygoni Multiflori 5-50
Herba Leonuri 5-60 Radix Bupleuri 3-30 Radix Angelicae Pubescentis 5-50
Also has Agkistrodon 1-3 bar in the crude drug.
Described medicament is oral liquid, granule, ball type, powder, capsule, electuary and tablet.
The preparation method of the Chinese medicine preparation of treatment treatment cardiovascular and cerebrovascular disease, make by following steps:
(1) crude drug of claim 1 being made as according to a conventional method water content is 10% aqueous extract;
(2) aqueous extract of using step (1) to make according to a conventional method is made as oral liquid;
(3) the aqueous extract drying that step (1) is obtained, pulverizing, mistake at least 200 mesh sieves, extracting screen underflow is extraction powder,
(4) the extraction powder of using step (3) to make according to a conventional method is made as tablet, granule, pill, electuary or capsule.
The preparation method of the Chinese medicine preparation of treatment treatment cardiovascular and cerebrovascular disease, fecula powder is made by following steps:
(1) with the described crude drug sieve of claim 1 dedust soil, pulverize,
(2) cross at least 200 mesh sieves,
(3) extracting screen underflow, sterilization, the pulvis of making a living,
The fecula powder of using step (3) to make according to a conventional method is made as tablet, granule, pill, electuary or capsule.
Chinese medicine thinks that cardiovascular and cerebrovascular disease is by disharmony between QI and blood, and blockage of main and collateral channels causes.The present invention mainly identifies and corrects according to Chinese medicine and executes the principle of controlling, the tame chief of the many doctors of collection, extensively adopt the strange medicine wonderful recipe in the rich Yunnan various nationalities of receipts area, based on pathogenetic understanding and the Therapeutic Principle of Chinese medicine to cardiovascular and cerebrovascular disease, reference is the pharmacological research achievement at all times, the screening inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, blood circulation promoting and blood stasis dispelling, refreshment and tranquilization, dredge the meridian passage, heat-clearing and toxic substances removing, the natural Chinese medicine of hypertension and hyperlipemia, by the theory of Chinese medical science prescription, skim the cream off milk, make its performance regulate the human body blood fat, vessel softening, blood viscosity lowering, recover blood vessel elasticity, functions such as microcirculation improvement form through the clinical practice summary of diagnosis and treatment case for a long time.
Prescription analysis of the present invention: Radix Achyranthis Bidentatae, Semen Persicae, Pollen Typhae, Radix Rubiae, Fructus Crataegi, Radix Paeoniae Rubra, Radix Notoginseng, Agkistrodon, Herba Erigerontis, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia; With Radix Astragali tonifying QI to promote blood circulation, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Caulis Spatholobi are enriched blood; With the Rhizoma Chuanxiong qi and blood circulation promotion; Fructus Liquidambaris, Pheretima, Hirudo, Scorpio, Bombyx Batryticatus, Radix Saposhnikoviae, Agkistrodon dispelling wind and removing obstruction in the collateral; With Radix Platycodonis, Arisaema Cum Bile, Fructus Trichosanthis, Fructus Aurantii, the Poria the chest stuffiness relieving that reduces phlegm; Rhizoma Acori Graminei, Radix Polygalae refreshment, calm the nerves, Fructus Alpiniae Oxyphyllae; Ramulus Cinnamomi, the Radix Puerariae network that activates yang; The Herba Agrimoniae hemostasis; The Radix Rubiae promoting blood circulation and hemostasis; The Folium Ginkgo heat-clearing and toxic substances removing; Haematitum, Concha Ostreae, Radix Salviae Miltiorrhizae blood pressure lowering; Antilipemic haw is invigorated blood circulation; The Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI is able to along reaching irritability, and with the same usefulness of Radix Paeoniae, it is submissive that liver blood is in harmonious proportion.
Medicine of the present invention is pressed the principle organic assembling of monarch, synergism all has curative effect preferably, treating both the principal and secondary aspects of a disease to various types of cardiovascular and cerebrovascular diseases, effectively vessel softening, recover blood vessel elasticity, dissolve thrombosis, suppress the formation of platelet aggregation and thrombosis, blood viscosity lowering, the effect of microcirculation improvement, strengthen the vigor of cardiovascular and cerebrovascular vessel, make heart keep operate as normal, blood pressure is steady.It is unobstructed that the present invention can make cardiovascular and cerebrovascular vessel and even whole body size blood capillary unclog and readjust, and in time removes the cell of cholesterol, triglyceride, free radical and necrosis etc., and these compositions will make blood vessel thicken, and passage diminishes, and increases blood flow resistance, reduces blood flow.The present invention can make the systemic blood operation unimpeded, and paralysis is removed gradually.The present invention cures mainly myocardial infarction, the angina pectoris that coronary heart disease, hypertension, cerebral thrombosis cause; Various symptoms such as hemiplegia, cerebral infarction, cerebrovascular accident, apoplexy sequela, cardiovascular and cerebrovascular disease such as the headache that causes to hypertension and because of cerebral blood supply insufficiency, dizziness has tangible curative effect.The present invention adopts pure Chinese medicine to make, and is esy to use, safe and reliable, liver, kidney, lung, stomach, spleen are all had no side effect, but life-time service.
The each 10-30ml of oral liquid of the present invention, day obeys oral 3 times, or chip select agent, granule, pill, powder, capsule, electuary etc. are wherein a kind of, each 3-10 gram, day obeys 3 times, various dosage forms can be used alternatingly, and extract powder and with each dosage form medicine and fecula powder and identical with each dosage form survival dose of its preparation of its preparation.Treating 30 days is a course of treatment, light disease 1-3 course of treatment, serious symptom 3-9 the course of treatment.
Taboo: 1, contraindication in pregnancy.4, period in a medicine ban on opium-smoking and the opium trade wine, Radix Raphani, fried and marinated food, spicy savoury food are eaten cattle, sheep, seafood and birds food less.Food less salt, low fat.
Attention: 1, menstrual phase is stopped using.2, this medicine should not with mix use in other medicines are placed on same container.3, the acute hemorrhage person is unsuitable.4, the spontaneous sweating person is unsuitable.
Clinical trial data of the present invention:
1, cerebral arteriosclerosis, cerebral thrombosis, apoplexy sequela
Adopt medicine of the present invention to follow the tracks of treatment cerebral arteriosclerosis, cerebral thrombosis, apoplexy sequela 100 examples, wherein, male's 69 examples, women's 31 examples, age 45-80 year.
Clinical symptoms: consciousness and visual disorder, paresis or hemiplegia, a side sensory disturbance, aphasis, movement disorder is diagnosed as patient's 46 examples of cerebral arteriosclerosis, cerebral thrombus patient's 29 examples, patient's 25 examples of apoplexy sequela through examination in hospital.
Therapeutic Method: medicine is an oral agents, selects in powder, tablet, pill, capsule, electuary, the oral liquid any, oral 3 times of every day, each 6-10 gram, 10 days is a course of treatment, 3-5 the course of treatment is effective usually, pertinacious disease needs 6-9 the course of treatment, and various dosage forms can be used alternatingly.
Therapeutic effect: after 3-5 the course of treatment of taking medicine, the produce effects patient that clinical symptoms disappears substantially is 39 examples, obvious effective rate 39%.Patient's 47 examples that clinical symptoms has part to reduce, effective percentage 47%, after 6-9 the course of treatment, the still unalterable patient of symptom is 14 examples, inefficiency 14%.In therapeutic process, do not see obvious adverse effect and toxic and side effects, do not have to find to have the phenomenon of liver, kidney, lung, stomach, spleen discomfort.
2, coronary heart disease, myocardial infarction, angina pectoris
Adopt medicine of the present invention to follow the tracks of treatment cardiovascular disease 100 examples, wherein, male's 67 examples, women's 33 examples, age 45-80 year.
Clinical symptoms: have palpitation, breathe hard, uncomfortable in chest, feel suffocated, symptom such as pained, insomnia, be patient's 45 examples of coronary heart disease through hospital diagnosis, patient with angina pectoris 30 examples, blood supply of cardiac muscle is on the low side, hospital diagnosis is patient's 25 examples of early stage myocardial infarction.Tcm diagnosis is not smooth because of QI-blood circulation, influences the blood clots absorbing and stagnates, and causes pained.
Therapeutic Method: medicine be in powder, tablet, pill, capsule, electuary, the oral liquid any, oral 3 times of every day, each 6-10 gram, 10 days is an outer course of treatment, usually 1-2 the course of treatment effective, 3-4 course of treatment of pertinacious disease need, also can various dosage forms can be used alternatingly.
Therapeutic effect: after taking medicine 3 days, symptom begins to alleviate or disappear.Take medicine after 1-5 the course of treatment, the healing patient of clinical symptoms complete obiteration is 61 people, cure rate 61%.The produce effects patient that clinical symptoms disappears substantially is 25 people, obvious effective rate 25%.Clinical symptoms has minimizing in various degree, and after 5 courses of treatment, effective patient that symptom still can not complete obiteration is 10 people, and effective percentage is 10%.After 5 courses of treatment, the invalid patient that symptom can not alleviate or disappear is 4 people, inefficiency 4%.In therapeutic process, do not have to find to have the phenomenon of liver, kidney, lung, stomach, spleen discomfort, do not see obvious adverse effect and toxic and side effects.
3, hypertension
Adopt medicine of the present invention to follow the tracks of treatment hypertension 100 examples, wherein, male's 68 examples, women's 32 examples, age 45-80 year is 1 phase hyperpietic, 37 examples through hospital diagnosis in the hypertension case, 2 phase hyperpietics, 39 examples, brain atrophy patient 5 examples appear in 3 phase hyperpietics, 24 examples among the hyperpietic.The patient generally has headache, dizzy phenomenon.
Therapeutic Method: medicine be in powder, tablet, pill, capsule, electuary, the oral liquid any, oral 3 times of every day, each 3-10 gram, 10 days is an outer course of treatment, usually 1-3 the course of treatment effective, 3-5 course of treatment of pertinacious disease need, also can various dosage forms can be used alternatingly.Take medicine after 3 courses of treatment, the healing patient that clinical symptoms disappears substantially is 68 people, obvious effective rate 68%.That clinical symptoms partly disappears is 28 people, effective percentage 28%, and wherein 5 routine brain atrophy patients' PD is controlled.The unaltered invalid patient of symptom is 4 people after 5 courses of treatment, inefficiency 4%.After 5 courses of treatment, do not have to find to have the phenomenon of liver, kidney, lung, stomach, spleen discomfort, do not have toxic and side effects.
The specific embodiment
Get the raw materials ready by table 1,
Table 1
| Sequence number | The Chinese medicine title | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| ??1 | The Radix Astragali (g) | ??30 | ??80 | ??120 | ??50 | ??100 |
| ??2 | Radix Salviae Miltiorrhizae (g) | ??60 | ??30 | ??10 | ??40 | ??20 |
| ??3 | Radix Paeoniae Rubra (g) | ??20 | ??25 | ??10 | ??30 | ??15 |
| ??4 | Rhizoma Chuanxiong (g) | ??30 | ??20 | ??15 | ??25 | ??10 |
| ??5 | Pheretima (g) | ??90 | ??60 | ??10 | ??20 | ??40 |
| ??6 | Hirudo (g) | ??10 | ??5 | ??8 | ??15 | ??12 |
| ??7 | Rhizoma Acori Graminei (g) | ??30 | ??10 | ??50 | ??60 | ??20 |
| ??8 | Radix Polygalae (g) | ??25 | ??20 | ??10 | ??15 | ??30 |
| ??9 | Haematitum (g) | ??10 | ??5 | ??30 | ??50 | ??60 |
| ??10 | Concha Ostreae (g) | ??20 | ??30 | ??20 | ??10 | ??5 |
| ??11 | Radix Angelicae Sinensis (g) | ??5 | ??30 | ??20 | ??15 | ??10 |
| ??12 | Radix Puerariae (g) | ??10 | ??50 | ??60 | ??20 | ??30 |
| ??13 | Arisaema Cum Bile (g) | ??5 | ??15 | ??10 | ??20 | ??30 |
| ??14 | Caulis Spatholobi (g) | ??10 | ??80 | ??60 | ??30 | ??90 |
| ??15 | Scorpio (g) | ??15 | ??1 | ??8 | ??10 | ??0.3 |
| ??16 | Fructus Trichosanthis (g) | ??60 | ??30 | ??50 | ??20 | ??10 |
| ??17 | Radix Saposhnikoviae (g) | ??5 | ??20 | ??10 | ??15 | ??30 |
| ??18 | Bombyx Batryticatus (g) | ??25 | ??15 | ??20 | ??30 | ??10 |
| ??19 | Ramulus Cinnamomi (g) | ??15 | ??12 | ??10 | ??3 | ??5 |
| ??20 | Herba Erigerontis (g) | ??0.1 | ??1 | ??0.5 | ??5 | ??15 |
| ??21 | Radix Platycodonis (g) | ??15 | ??8 | ??5 | ??10 | ??3 |
| Sequence number | The Chinese medicine title | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| ??22 | Fructus Aurantii (g) | ??10 | ??12 | ??15 | ??3 | ??5 |
| ??23 | Fructus Crataegi (g) | ??60 | ??5 | ??30 | ??10 | ??40 |
| ??24 | Radix Rubiae (g) | ??3 | ??40 | ??10 | ??60 | ??20 |
| ??25 | Poria (g) | ??120 | ??10 | ??80 | ??100 | ??30 |
| ??26 | Herba Agrimoniae (g) | ??5 | ??90 | ??50 | ??10 | ??70 |
| ??27 | Fructus Liquidambaris (g) | ??30 | ??3 | ??10 | ??20 | ??6 |
| ??28 | Semen Persicae (g) | ??0.1 | ??15 | ??5 | ??1 | ??10 |
| ??29 | Flos Carthami (g) | ??15 | ??0.1 | ??5 | ??10 | ??1 |
| ??30 | Pollen Typhae (g) | ??0.1 | ??15 | ??10 | ??1 | ??6 |
| ??31 | Ganoderma (g) | ??20 | ??3 | ??20 | ??30 | ??10 |
| ??32 | Radix Achyranthis Bidentatae (g) | ??15 | ??30 | ??6 | ??10 | ??20 |
| ??33 | Radix Notoginseng (g) | ??30 | ??3 | ??10 | ??60 | ??50 |
| ??34 | Folium Ginkgo (g) | ??10 | ??30 | ??20 | ??3 | ??15 |
| ??35 | Herba Siegesbeckiae (g) | ??15 | ??3 | ??30 | ??20 | ??10 |
| ??36 | Radix Polygoni Multiflori (g) | ??15 | ??40 | ??5 | ??50 | ??30 |
| ??37 | Herba Leonuri (g) 0 | ??60 | ??10 | ??50 | ??5 | ??30 |
| ??38 | Radix Bupleuri (g) | ??3 | ??20 | ??10 | ??30 | ??15 |
| ??39 | Radix Angelicae Pubescentis (g) | ??25 | ??50 | ??25 | ??5 | ??15 |
| ??40 | Agkistrodon (bar) | ??2 | ??3 | ??1 | ??1 | ??2 |
1, use medicine water extract system to treat the method for the Chinese medicine oral liquid of cardiovascular and cerebrovascular disease, powder, tablet, pill, capsule
Press table 1 and be equipped with crude drug, concrete preparation method:
(1) the described medicine of table 1 being made as according to a conventional method water content is 10% aqueous extract;
(2) aqueous extract that makes with step (1) is made as oral liquid according to a conventional method;
(3) the aqueous extract drying that step (1) is obtained, pulverizing, mistake at least 200 mesh sieves, the sterilization of extracting screen underflow conventional method is extraction powder,
(4) the extraction powder of using step (3) to make according to a conventional method is made as tablet, pill, electuary or capsule.
2, the method for using fecula powder system to treat the Chinese powder medicine of cardiovascular and cerebrovascular disease, tablet, pill, capsule is pressed table 1 crude drug fully, concrete preparation method:
(1) with the described drug sieve dedust of table 1 soil, pulverize, the medicine temperature is lower than 60 ℃ during pulverizing, and the medicine temperature is too high during pulverizing is easy to generate burnt paste or changes the property of medicine,
(2) cross at least 200 mesh sieves, extracting screen underflow,
(3) pulvis of making a living of sterilizing according to a conventional method, sterilize,
(4) the film-making agent according to a conventional method of fecula powder, pill, the capsule that makes with step (3).
Claims (4)
1. Chinese medicine for the treatment of cardiovascular and cerebrovascular disease is characterized in that it is the medicament of being made by following weight parts proportion raw material medical material:
Radix Astragali 30-120 Radix Salviae Miltiorrhizae 10-60 Radix Paeoniae Rubra 10-30 Rhizoma Chuanxiong 10-30
Pheretima 10-90 Hirudo 5-15 Rhizoma Acori Graminei 10-60 Radix Polygalae 10-30
Haematitum 5-60 Concha Ostreae 5-30 Radix Angelicae Sinensis 5-30 Radix Puerariae 10-60
Arisaema Cum Bile 5-30 Caulis Spatholobi 10-90 Scorpio 0.3-15 Fructus Trichosanthis 10-60
Radix Saposhnikoviae 5-30 Bombyx Batryticatus 5-30 Ramulus Cinnamomi 3-15 Herba Erigerontis 0.1-15
Radix Platycodonis 3-15 Fructus Aurantii 3-15 Fructus Crataegi 5-60 Radix Rubiae 3-60
Poria 10-120 Herba Agrimoniae 5-90 Fructus Liquidambaris 3-30 Semen Persicae 0.1-15
Flos Carthami 0.1-15 Pollen Typhae 0.1-15 Ganoderma 3-30 Radix Achyranthis Bidentatae 6-30
Radix Notoginseng 3-60 Herba Siegesbeckiae 3-30 Folium Ginkgo 3-30 Radix Polygoni Multiflori 5-50
Herba Leonuri 5-60 Radix Bupleuri 3-30 Radix Angelicae Pubescentis 5-50
Also has Agkistrodon 1-3 bar in the crude drug.
2. the Chinese medicine of treatment cardiovascular and cerebrovascular disease according to claim 1 is characterized in that, described medicament is oral liquid, granule, ball type, powder, capsule, electuary and tablet.
3. the preparation method of Chinese medicine preparation of a treatment cardiovascular and cerebrovascular disease is characterized in that being made by following steps:
(1) crude drug of claim 1 being made as according to a conventional method water content is 10% aqueous extract;
(2) aqueous extract of using step (1) to make according to a conventional method is made as oral liquid;
(3) the aqueous extract drying that step (1) is obtained, pulverizing, mistake at least 200 mesh sieves, extracting screen underflow is extraction powder,
(4) the extraction powder of using step (3) to make according to a conventional method is made as tablet, granule, pill, electuary or capsule.
4. the preparation method of Chinese medicine preparation of a treatment cardiovascular and cerebrovascular disease is characterized in that fecula powder made by following steps:
(1) with the described crude drug sieve of claim 1 dedust soil, pulverize,
(2) cross at least 200 mesh sieves,
(3) extracting screen underflow, sterilization, the pulvis of making a living,
(4) the fecula powder of using step (3) to make according to a conventional method is made as tablet, granule, pill, electuary or capsule.
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