CN105708985A - Medicine for dredging cardiovascular system and preparation method thereof - Google Patents
Medicine for dredging cardiovascular system and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for dredging the cardiovascular system, which is mainly prepared from the following raw materials in parts by weight: 1-3 parts of dentiferous dendropanax root and stem, 1-3 parts of common christia herb, 1-5 parts of red sage root, 1-5 parts of eucommia, 1-3 parts of altai anemone rhizome, 1-3 parts of dogwood pulp, 1-3 parts of chuanxiong rhizome, 1-3 parts of angelica sinensis root, 1-3 parts of licorice, 1-3 parts of radix clematidis, 1-5 parts of herba cistanche, 1-5 parts of american ginseng, 1-5 parts of pseudo-ginseng, 1-3 parts of saffron and 1-3 parts of polygala root. The invention also discloses a preparation method of the medicine for dredging the cardiovascular system. The medicine for dredging the cardiovascular system is used for preventing and treating cardiovascular diseases, is capable of improving the cardiovascular functions of a human body, comprehensively adjusting the organs of the human body, strengthening the kidneys and nourishing the liver as well as improving the immunity of the human body to prevent diseases, and has the advantages of good curative effect, thorough prevention and treatment, no toxic or side effect, no dependence, no recurrence after healing, and the like.
Description
Technical field
The present invention relates to cardiovascular drugs field.It is more particularly related to a kind of dredging cardiovascular drugs and preparation thereof
Method.
Background technology
Cardiovascular and cerebrovascular disease refers to heart ischemia that heart and arteries hardened and cause or hemorrhage disease, including hat
Cardiopathia, angina pectoris, hypertension, arrhythmia, myocardial infarction, cerebral infarction are waited indefinitely.The prevalence of cardiovascular disease is year by year at present
Rising and present rejuvenation trend, obese people, that gluttony crapulence crowd suffers from cardiovascular disease is more.In August, 2015 is up-to-date
Authority's statistical data shows, suffers from cardiovascular disease number and has reached 2.9 hundred million, just has two people in average ten people.Prevent the most early,
Treatment cardiovascular disease, is the instant healthy major issues of we compatriots.
In existing clinical treatment, western medical treatment mainly has the medicines such as expansion blood vessel, thrombolytic, blood pressure lowering, and it responds well to treatment soon,
Being applicable to rescue treatment, but the side effect of Western medicine is relatively big, blood vessel and human organ can be brought in various degree by life-time service
Injure and there is certain dependency.Chinese medicine prevention cardiovascular diseases focuses on conditioning, and the comprehensive rehabilitation to physical function has very much
Benefit, side effect is less, has certain advantage, but existing Chinese medicine to there is the course for the treatment of when treating cardiovascular disease long, take effect
Slowly.Play Chinese medicine advantage in terms of prevention and cure of cardiovascular disease the most further, improve clinical timeliness, be Chinese medicine urgently
The problem solved.
Summary of the invention
It is an object of the invention to solve at least the above, and the advantage that at least will be described later is provided.
It is a still further object of the present invention to provide a kind of dredging cardiovascular drugs, cardiovascular and cerebrovascular disease can not only be played early by it
Prevention, the effect for the treatment of, moreover it is possible to each organ of across-the-board regulation human body, particularly improve human body cardiovascular function, kidney tonifying nourishing the liver,
Improving body immunity, diseases prevention is in possible trouble.
It is a still further object of the present invention to provide a kind of preparation method dredging cardiovascular drugs, it is according to component each in prescription
Characteristic, carries out extracting for changing, makes the effective ingredient of each component be fully dissolved out, retain, substantially increase dredging cardiovascular drug
The drug effect of thing.
In order to realize according to object of the present invention and further advantage, it is provided that a kind of dredging cardiovascular drugs, mainly by pressing
The following raw material of weight portion meter is made: Sassafras tsumu Hemsl. 1-3 part, Herba Christiae 1-3 part, Radix Salviae Miltiorrhizae 1-5 part, Cortex Eucommiae 1-5 part,
Rhizoma Anemones Altaicae 1-3 part, Fructus Corni officinalis 1-3 part, Rhizoma Chuanxiong 1-3 part, Radix Angelicae Sinensis 1-3 part, Radix Glycyrrhizae 1-3 part, Radix Clematidis 1-3 part,
Herba Cistanches 1-5 part, Radix Panacis Quinquefolii 1-5 part, Radix Notoginseng 1-5 part, Stigma Croci 1-3 part and Radix Polygalae 1-3 part.
Preferably, described dredging cardiovascular drugs, mainly it is made up of following raw material by weight: Sassafras tsumu Hemsl. 2 parts,
Herba Christiae 2 parts, Radix Salviae Miltiorrhizae 3 parts, the Cortex Eucommiae 3 parts, Rhizoma Anemones Altaicae 2 parts, Fructus Corni officinalis 2 parts, Rhizoma Chuanxiong 2 parts, Radix Angelicae Sinensis 2
Part, 2 parts of Radix Glycyrrhizae, Radix Clematidis 2 parts, Herba Cistanches 3 parts, Radix Panacis Quinquefolii 3 parts, Radix Notoginseng 3 parts, Stigma Croci 2 parts and Radix Polygalae 2 parts.
Preferably, described dredging cardiovascular drugs, described Radix Salviae Miltiorrhizae is Radix Salviae Miltiorrhizae (processed with wine)；The described Cortex Eucommiae is Cortex Eucommiae (processed with salt)；Institute
Stating Radix Polygalae is processed with honey Radix Polygalae.
The preparation method of a kind of described dredging cardiovascular drugs, comprises the steps:
Step one, Herba Cistanches by prescription, Radix Panacis Quinquefolii, Radix Notoginseng, Stigma Croci and Cortex Eucommiae micronizing respectively is to 500-700
Mesh, remaining component in prescription is crushed to 80-100 mesh respectively；
Step 2, the Herba Christiae taking above-mentioned weight portion and Sassafras tsumu Hemsl., after mix homogeneously, be 40-55%'s through volume fraction
Ethanol hyperpressure extraction, obtains the first filtrate and the first filtering residue, by described first filtering residue through water hyperpressure extraction, obtains the second filtrate
With the second filtering residue, merging the first filtrate and the second filtrate, being evaporated to relative density is 1.2-1.3, obtains the first thick paste；
Step 3, take the Rhizoma Chuanxiong of above-mentioned weight portion, Radix Polygalae and Radix Salviae Miltiorrhizae, after mix homogeneously, be 85-90%'s through volume fraction
Alcohol reflux, obtains the 3rd filtrate and the 3rd filtering residue, is returned through the ethanol that volume fraction is 40-55% by described 3rd filtering residue
Stream extracts, and obtains the 4th filtrate and the 4th filtering residue, by described 4th filtering residue through water reflux, extract, obtains the 5th filtrate and the 5th filtering residue,
Merging the 3rd filtrate, the 4th filtrate and the 5th filtrate, being evaporated to relative density is 1.2-1.3, obtains the second thick paste；
Step 4, take the Radix Angelicae Sinensis of above-mentioned weight portion, Radix Glycyrrhizae, Radix Clematidis, Fructus Corni officinalis and Rhizoma Anemones Altaicae, through water reflux, extract,
Obtain the 6th filtrate and the 6th filtering residue；
Step 5, take the Herba Cistanches of above-mentioned weight portion, Radix Panacis Quinquefolii, Radix Notoginseng, Stigma Croci and the Cortex Eucommiae, be added into the 6th filtrate
In, it is 1.2-1.3 that ultrasound wave dispersion is evaporated to relative density after extracting, and obtains the 3rd thick paste；
Step 6, merge the first thick paste, the second thick paste and the 3rd thick paste, and mix homogeneously.
Preferably, the preparation method of described dredging cardiovascular drugs, also include after described step 6:
Step 7, add pharmaceutically acceptable adjuvant, prepared by the first thick paste, the second thick paste and the 3rd thick paste after merging
Become electuary, tablet or capsule.
Preferably, the preparation method of described dredging cardiovascular drugs, in described step 2, volume fraction is 40-55%
Ethanol and Herba Christiae and the weight ratio of Sassafras tsumu Hemsl. be 5-10:1, water is 5-10:1 with the weight ratio of described first filtering residue, super
High pressure extraction conditions is: pressure 600-700MPa, extraction time 5-8min.
Preferably, the preparation method of described dredging cardiovascular drugs, in described step 3, volume fraction is 85-90%
The weight ratio of ethanol and Rhizoma Chuanxiong, Radix Polygalae and Radix Salviae Miltiorrhizae be 10-15:1, volume fraction is the ethanol of 40-55% and described 3rd filter
The weight ratio of slag is 10-15:1, and water is 8-12:1 in the weight ratio of described 4th filtering residue, and reflux, extract, condition is: Extracting temperature
50-60 DEG C, reflow's cycle 2-3 time, each return time 0.5-1h.
Preferably, the preparation method of described dredging cardiovascular drugs, in described step 4, water and described Radix Angelicae Sinensis, Radix Glycyrrhizae,
The weight ratio of Radix Clematidis, Fructus Corni officinalis and Rhizoma Anemones Altaicae is 15-20:1, and reflux, extract, condition is: Extracting temperature 70-80 DEG C, returns
Stream number of times 2-3 time, each return time 1-1.5h.
Preferably, the preparation method of described dredging cardiovascular drugs, in described step 5, ultrasound wave dispersion extraction conditions
For ultrasonic power 400-500W, ultrasonic number of times 4-6 time, adjacent twice ultrasonic interval time 20-25min, wherein,
For the first time with the ultrasonic each ultrasonic time 12-15min of second time, from third time ultrasonic beginning each ultrasonic time 8-10min.
In prescription of the present invention, the characteristic of each component is as follows:
(1) Sassafras tsumu Hemsl.: Seedling doctor's medical herbs, main enter Liver Channel blood system, temperatureization circulation of qi promoting, uniqueness be this kind by three plant varieties,
Through thousands of years natural breeding form, wherein: maple class is good at expelling wind and dampness, circulation of qi promoting blood stasis removing, lotus wood class be good at whole body the meridian dredging,
Bone and muscle strengthening, evil-wind expelling and dampness removing, osmanthus wood class be good at temperatureization promoting the circulation of blood, invigorate blood circulation, dredging collateral is walked to alter, dispeling cold numbness, pain relieving, wind dispelling,
Walk by force extremity and blood capillary.
(2) Herba Christiae: strong doctor's medical herbs, master enters Liver Channel blood system, pungent cool circulation of qi promoting, has uniqueness to help blood to walk the merit altered, and lives
Blood and dissolving stasis, and fragrant odour uniqueness etc..
(3) Radix Salviae Miltiorrhizae: Chinese medicine, Slight Cold, slightly hardship, enters pericardium channel, Liver Channel, is good at into blood system, and cardiovascular disease is normal
The flat blood pressure of three-hypers, life removing heat from blood, antiinflammatory, drop in medication, and after wine is concocted, the effect ofactivating blood circulation to dissipate blood stasis is strengthened.
(4) Cortex Eucommiae: Chinese medicine, sweet, warm, return liver, kidney channel, be good at mend true strength gas, replenishing essence marrow, strengthening bone and muscle,
Return first of unit for essence, gas, god's threeway, still better through salt brewed the kidney invigorating blood pressure lowering, more can mend and receive true strength kidney qi, be just to promote blood
Often active dose of circulation.
(5) Radix Panacis Quinquefolii: Traditional health care class medicine, hardship sweet, micro-, attach to the lung and stomach meridians, be good at tonifying the lung gas, enhancing immunity it
First-selected tonic.
(6) Radix Notoginseng: Chinese medicine, warm, sweet, bitter, return liver, stomach warp, be good at into blood system, blood circulation promoting and blood stasis dispelling, stop blooding,
Antiinflammatory, pain relieving, after brewed, have and dispel old blood and the special effect of tissue regeneration promoting blood, more can strengthening QI of middle-JIAO.
(7) Stigma Croci: Chinese medicine, tepor, sweet in the mouth, micro-acid, GUIXIN, Liver Channel, it is good at into blood system, blood circulation promoting and blood stasis dispelling,
The drug of first choice that unique logical capillary of kidney is unimpeded, can increase renal blood flow, protect kidney.Crocetin sodium contained by Stigma Croci
Salt, crocetin fat can improve stem cell degeneration, the effect of protected liver；α-crocetin is the effective ingredient of blood fat reducing,
Can substantially reduce internal heart and gallbladder sterin, reduce body abnormal blood pressure, atherosclerotic prevention and treatment are had well
Help；Stigma Croci potassium content is the highest, can protect tunica intima and can expand blood vessel, increases tunica intima permeability and smooth merit
Can, reduce cholesterol and deposit in arterial wall.
(8) Radix Polygalae: Chinese medicine, bitter, pungent, tepor, GUIXIN, kidney, lung meridian, it is good at and drives expectorant, profit nine orifices the most happily
Key, have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subside a swelling, haemolysis, defying age, the function of anticancer change, more preferable with processed with honey effect.
(9) Fructus Corni officinalis: conventional Chinese medicine, pungent, temperature, return liver, gallbladder, pericardium channel, cure mainly pathogen cold and heat under the heart, warming middle-JIAO,
By cold temperature numbness, there are reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, liver and kidney tonifying, regulate immunologic function.
(10) Rhizoma Chuanxiong: conventional Chinese medicine, pungent, temperature, return liver, gallbladder, pericardium channel, there is the effect of blood-activating and qi-promoting, wind-expelling pain-stopping,
Pungent scattered temperature is led to, and can invigorate blood circulation, again can circulation of qi promoting, for " gas medicine in blood ", can the key medicine of " lower regulating menstruation water, middle relieving stagnation ",
No matter wind and cold, wind heat, rheumatism, blood stasis, abnormal smells from the patient perfume (or spice) is altered, and walks and does not keeps, can on reach top, mountain peak, the lower logical sea of blood, outer thorough fur,
Bypass extremity, its blood-activating and qi-promoting, can go up thin wind syndrome of head, and brain is returned through required medicine, the distinguished service of lower logical kidney qi.
(11) Radix Clematidis: hardship pungent, salty, micro-, temperature, returns bladder, Liver Channel, is good at wind dispelling dredging collateral and walks to alter.
(12) Herba Cistanches: Gan Xian, temperature, return kidney channel, its mend and oiliness, warm and the driest, sweet can qi-restoratives, salty can enter kidney,
Kidney storing essence, is good at the key medicine of the medicine of the foster gate of vitality, nourishing kidney gas, replenishing vital essence and blood.
(13) Radix Angelicae Sinensis: the root hair of Chinese medicine angelica, sweet, pungent, warm, GUIXIN, liver, spleen channel, it is good at blood circulation and promoting silt.
(14) Rhizoma Anemones Altaicae: pungent, warm, GUIXIN, liver, spleen channel, there is waking up the patient from unconsciousness by dissipating phlegm, calm the nerves, declare and wet be amusing, detoxify
Effect.
(15) Radix Glycyrrhizae: sweet, flat, GUIXIN, spleen, lung, stomach warp, invigorating the spleen and replenishing QI, it is good at gentle solution hundred poison.
The present invention at least includes following beneficial effect:
The first, the dredging cardiovascular drugs of the present invention is considered from the source of the cardiovascular disease such as hypertension, coronary heart disease, for length
The conversion pathological changes of phase, in line with strengthening the vigor of cell, rapid thrombus, remove the endovascular stasis of blood and amass, vessel softening and carrying
High immunity of organisms, anti-ageing principle of waiting for a long time, use multiple national characters Chinese herbal medicine, uses Chinese medicine monarch medication policy,
Utilizing the characteristic of every kind of medicine, Gui Jing, circulation of qi promoting, QI invigorating, blood circulation promoting and blood stasis dispelling, damp eliminating, antiinflammatory, the kidney invigorating, to counteract each other, temperature
Cool and look at each other by, specimen, mutually auxiliary form, the collocation of the monarch and his subjects' principal agent is characteristic, regulates function of human body comprehensively, reaches alive
The serum stasis of blood, supports the purpose of kidney tonifying liver, have good effect, preventing and treating thoroughly, have no side effect, no dependence, the recurrence after healing can be avoided
Etc. advantage；
The second, the dredging cardiovascular drugs of the present invention can effectively remove the dirt of blood vessel, the rubbish removed in blood and poison
Element, smooth blood vessel, moreover it is possible to effectively activate myocardial cell, strengthen cardiac muscle oxygen and myocardial viability, reduce cholesterol, Lipid
Accumulation in blood vessel wall is formed, and makes blood unblocked at Ink vessel transfusing, makes the blood vessel of the heart, brain, kidney, liver and each internal organs obtain
Soften, promote blood capillary to regenerate, make the non-viable non-apoptotic cell of aging clear out in human body, steady blood pressure, so that blood
Produce benign cycle, recover human normal cardiovascular function；
3rd, the dredging cardiovascular drugs of the present invention is when preventing and treating hypertension, the Gene regulation in medicine and effective active molecule
Blood can be entered, through diseased region focus, in steady pressure reduction, nourishing liver and kidney, repair each tissue that human body is impaired
Organ, controls the pathogenetic gene of blood blood vessel, regulates human activin immune system, and blood circulation promoting is normal, fundamentally
Thoroughly reversing hypertension pathogenesis, has the effect for the treatment of both the principal and secondary aspects of a disease, when taking medicine to a certain extent, can withdrawal, treat
Effect is stable；
4th, the dredging cardiovascular drugs of the present invention is used for prevention and cure of cardiovascular disease, improves human body cardiovascular function, adjusts comprehensively
The each organ of body of giving sb. a hard time, kidney tonifying nourishing the liver, improve body immunity, and diseases prevention is in possible trouble.
Part is embodied by the further advantage of the present invention, target and feature by description below, and part also will be by the present invention
Research and practice and be understood by the person skilled in the art.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, to make those skilled in the art with reference to description word
Can implement according to this.
It should be noted that experimental technique described in following embodiment, if no special instructions, it is conventional method, described examination
Agent and material, if no special instructions, the most commercially obtain.
Embodiment 1:
A kind of dredging cardiovascular drugs, is mainly made up of following raw material by weight: Sassafras tsumu Hemsl. 1 part, Herba Christiae 1
Part, Radix Salviae Miltiorrhizae 1 part, the Cortex Eucommiae 1 part, Rhizoma Anemones Altaicae 1 part, Fructus Corni officinalis 1 part, Rhizoma Chuanxiong 1 part, Radix Angelicae Sinensis 1 part, Radix Glycyrrhizae 1
Part, Radix Clematidis 1 part, Herba Cistanches 1 part, Radix Panacis Quinquefolii 1 part, Radix Notoginseng 1 part, Stigma Croci 1 part and Radix Polygalae 1 part.
Described dredging cardiovascular drugs, described Radix Salviae Miltiorrhizae is Radix Salviae Miltiorrhizae (processed with wine)；The described Cortex Eucommiae is Cortex Eucommiae (processed with salt)；Described Radix Polygalae is honey
Radix Polygalae (processed).
The preparation method of a kind of described dredging cardiovascular drugs, comprises the steps:
Step one, Herba Cistanches by prescription, Radix Panacis Quinquefolii, Radix Notoginseng, Stigma Croci and Cortex Eucommiae micronizing respectively to 500 mesh,
Remaining component in prescription is crushed to 80 mesh respectively；
Step 2, the Herba Christiae taking above-mentioned weight portion and Sassafras tsumu Hemsl., after mix homogeneously, be the ethanol of 40% through volume fraction
Hyperpressure extraction, obtains the first filtrate and the first filtering residue, by described first filtering residue through water hyperpressure extraction, obtains the second filtrate and
Two filtering residues, merge the first filtrate and the second filtrate, and being evaporated to relative density is 1.2, obtains the first thick paste；
Step 3, take the Rhizoma Chuanxiong of above-mentioned weight portion, Radix Polygalae and Radix Salviae Miltiorrhizae, after mix homogeneously, be the ethanol of 85% through volume fraction
Reflux, extract, obtains the 3rd filtrate and the 3rd filtering residue, by described 3rd filtering residue through volume fraction be the alcohol reflux of 40%,
The 4th filtrate and the 4th filtering residue, by described 4th filtering residue through water reflux, extract, obtain the 5th filtrate and the 5th filtering residue, merging the
Three filtrates, the 4th filtrate and the 5th filtrate, being evaporated to relative density is 1.2, obtains the second thick paste；
Step 4, take the Radix Angelicae Sinensis of above-mentioned weight portion, Radix Glycyrrhizae, Radix Clematidis, Fructus Corni officinalis and Rhizoma Anemones Altaicae, through water reflux, extract,
Obtain the 6th filtrate and the 6th filtering residue；
Step 5, take the Herba Cistanches of above-mentioned weight portion, Radix Panacis Quinquefolii, Radix Notoginseng, Stigma Croci and the Cortex Eucommiae, be added into the 6th filtrate
In, it is 1.2 that ultrasound wave dispersion is evaporated to relative density after extracting, and obtains the 3rd thick paste；
Step 6, merge the first thick paste, the second thick paste and the 3rd thick paste, and mix homogeneously.
The preparation method of described dredging cardiovascular drugs, also includes after described step 6:
Step 7, add pharmaceutically acceptable adjuvant, prepared by the first thick paste, the second thick paste and the 3rd thick paste after merging
Become electuary, tablet or capsule.
The preparation method of described dredging cardiovascular drugs, in described step 2, volume fraction is ethanol and the round trip flight butterfly of 40%
The weight ratio of butterfly and Sassafras tsumu Hemsl. is 5:1, and water is 5:1 with the weight ratio of described first filtering residue, and hyperpressure extraction condition is: pressure
600MPa, extraction time 5min.
The preparation method of described dredging cardiovascular drugs, in described step 3, volume fraction be 85% ethanol and Rhizoma Chuanxiong,
The weight ratio of Radix Polygalae and Radix Salviae Miltiorrhizae is 10:1, and volume fraction is the ethanol of 40% and the weight ratio of described 3rd filtering residue is 10:1, water
Weight ratio in described 4th filtering residue is 8:1, and reflux, extract, condition is: Extracting temperature 50 DEG C, reflow's cycle 2 times, every time
Return time 0.5h.
The preparation method of described dredging cardiovascular drugs, in described step 4, water and described Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Clematidis, mountain
The weight ratio of Fructus Evodiae meat and Rhizoma Anemones Altaicae is 15:1, and reflux, extract, condition is: Extracting temperature 70 DEG C, reflow's cycle 2 times,
Return time 1h every time.
The preparation method of described dredging cardiovascular drugs, in described step 5, ultrasound wave dispersion extraction conditions is: ultrasound wave
Power 400W, ultrasonic number of times 4 times, adjacent twice ultrasonic interval time 20min, wherein, for the first time and second time is the most ultrasonic
Ultrasonic time 12min every time, from third time ultrasonic beginning each ultrasonic time 8min.
Embodiment 2:
A kind of dredging cardiovascular drugs, is mainly made up of following raw material by weight: Sassafras tsumu Hemsl. 2 parts, Herba Christiae 2
Part, Radix Salviae Miltiorrhizae 3 parts, the Cortex Eucommiae 3 parts, Rhizoma Anemones Altaicae 2 parts, Fructus Corni officinalis 2 parts, Rhizoma Chuanxiong 2 parts, Radix Angelicae Sinensis 2 parts, Radix Glycyrrhizae 2
Part, Radix Clematidis 2 parts, Herba Cistanches 3 parts, Radix Panacis Quinquefolii 3 parts, Radix Notoginseng 3 parts, Stigma Croci 2 parts and Radix Polygalae 2 parts.
Described dredging cardiovascular drugs, described Radix Salviae Miltiorrhizae is Radix Salviae Miltiorrhizae (processed with wine)；The described Cortex Eucommiae is Cortex Eucommiae (processed with salt)；Described Radix Polygalae is honey
Radix Polygalae (processed).
The preparation method of a kind of described dredging cardiovascular drugs, comprises the steps:
Step one, Herba Cistanches by prescription, Radix Panacis Quinquefolii, Radix Notoginseng, Stigma Croci and Cortex Eucommiae micronizing respectively to 600 mesh,
Remaining component in prescription is crushed to 90 mesh respectively；
Step 2, the Herba Christiae taking above-mentioned weight portion and Sassafras tsumu Hemsl., after mix homogeneously, be the ethanol of 47% through volume fraction
Hyperpressure extraction, obtains the first filtrate and the first filtering residue, by described first filtering residue through water hyperpressure extraction, obtains the second filtrate and
Two filtering residues, merge the first filtrate and the second filtrate, and being evaporated to relative density is 1.25, obtains the first thick paste；
Step 3, take the Rhizoma Chuanxiong of above-mentioned weight portion, Radix Polygalae and Radix Salviae Miltiorrhizae, after mix homogeneously, be the ethanol of 87% through volume fraction
Reflux, extract, obtains the 3rd filtrate and the 3rd filtering residue, by described 3rd filtering residue through volume fraction be the alcohol reflux of 47%,
The 4th filtrate and the 4th filtering residue, by described 4th filtering residue through water reflux, extract, obtain the 5th filtrate and the 5th filtering residue, merging the
Three filtrates, the 4th filtrate and the 5th filtrate, being evaporated to relative density is 1.25, obtains the second thick paste；
Step 4, take the Radix Angelicae Sinensis of above-mentioned weight portion, Radix Glycyrrhizae, Radix Clematidis, Fructus Corni officinalis and Rhizoma Anemones Altaicae, through water reflux, extract,
Obtain the 6th filtrate and the 6th filtering residue；
Step 5, take the Herba Cistanches of above-mentioned weight portion, Radix Panacis Quinquefolii, Radix Notoginseng, Stigma Croci and the Cortex Eucommiae, be added into the 6th filtrate
In, it is 1.25 that ultrasound wave dispersion is evaporated to relative density after extracting, and obtains the 3rd thick paste；
Step 6, merge the first thick paste, the second thick paste and the 3rd thick paste, and mix homogeneously.
The preparation method of described dredging cardiovascular drugs, also includes after described step 6:
Step 7, add pharmaceutically acceptable adjuvant, prepared by the first thick paste, the second thick paste and the 3rd thick paste after merging
Become electuary, tablet or capsule.
The preparation method of described dredging cardiovascular drugs, in described step 2, volume fraction is ethanol and the round trip flight butterfly of 47%
The weight ratio of butterfly and Sassafras tsumu Hemsl. is 8:1, and water is 8:1 with the weight ratio of described first filtering residue, and hyperpressure extraction condition is: pressure
650MPa, extraction time 6min.
The preparation method of described dredging cardiovascular drugs, in described step 3, volume fraction be 87% ethanol and Rhizoma Chuanxiong,
The weight ratio of Radix Polygalae and Radix Salviae Miltiorrhizae is 12:1, and volume fraction is the ethanol of 47% and the weight ratio of described 3rd filtering residue is 12:1, water
Weight ratio in described 4th filtering residue is 10:1, and reflux, extract, condition is: Extracting temperature 55 DEG C, reflow's cycle 3 times, often
Secondary return time 0.8h.
The preparation method of described dredging cardiovascular drugs, in described step 4, water and described Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Clematidis, mountain
The weight ratio of Fructus Evodiae meat and Rhizoma Anemones Altaicae is 18:1, and reflux, extract, condition is: Extracting temperature 75 DEG C, reflow's cycle 3 times,
Return time 1.2h every time.
The preparation method of described dredging cardiovascular drugs, in described step 5, ultrasound wave dispersion extraction conditions is: ultrasound wave
Power 450W, ultrasonic number of times 5 times, adjacent twice ultrasonic interval time 22min, wherein, for the first time and second time is the most ultrasonic
Ultrasonic time 13min every time, from third time ultrasonic beginning each ultrasonic time 9min.
Embodiment 3:
A kind of dredging cardiovascular drugs, is mainly made up of following raw material by weight: Sassafras tsumu Hemsl. 3 parts, Herba Christiae 3
Part, Radix Salviae Miltiorrhizae 5 parts, the Cortex Eucommiae 5 parts, Rhizoma Anemones Altaicae 3 parts, Fructus Corni officinalis 3 parts, Rhizoma Chuanxiong 3 parts, Radix Angelicae Sinensis 3 parts, Radix Glycyrrhizae 3
Part, Radix Clematidis 3 parts, Herba Cistanches 5 parts, Radix Panacis Quinquefolii 5 parts, Radix Notoginseng 5 parts, Stigma Croci 3 parts and Radix Polygalae 3 parts.
Described dredging cardiovascular drugs, described Radix Salviae Miltiorrhizae is Radix Salviae Miltiorrhizae (processed with wine)；The described Cortex Eucommiae is Cortex Eucommiae (processed with salt)；Described Radix Polygalae is honey
Radix Polygalae (processed).
The preparation method of a kind of described dredging cardiovascular drugs, comprises the steps:
Step one, Herba Cistanches by prescription, Radix Panacis Quinquefolii, Radix Notoginseng, Stigma Croci and Cortex Eucommiae micronizing respectively to 700 mesh,
Remaining component in prescription is crushed to 100 mesh respectively；
Step 2, the Herba Christiae taking above-mentioned weight portion and Sassafras tsumu Hemsl., after mix homogeneously, be the ethanol of 55% through volume fraction
Hyperpressure extraction, obtains the first filtrate and the first filtering residue, by described first filtering residue through water hyperpressure extraction, obtains the second filtrate and
Two filtering residues, merge the first filtrate and the second filtrate, and being evaporated to relative density is 1.3, obtains the first thick paste；
Step 3, take the Rhizoma Chuanxiong of above-mentioned weight portion, Radix Polygalae and Radix Salviae Miltiorrhizae, after mix homogeneously, be the ethanol of 90% through volume fraction
Reflux, extract, obtains the 3rd filtrate and the 3rd filtering residue, by described 3rd filtering residue through volume fraction be the alcohol reflux of 55%,
The 4th filtrate and the 4th filtering residue, by described 4th filtering residue through water reflux, extract, obtain the 5th filtrate and the 5th filtering residue, merging the
Three filtrates, the 4th filtrate and the 5th filtrate, being evaporated to relative density is 1.3, obtains the second thick paste；
Step 4, take the Radix Angelicae Sinensis of above-mentioned weight portion, Radix Glycyrrhizae, Radix Clematidis, Fructus Corni officinalis and Rhizoma Anemones Altaicae, through water reflux, extract,
Obtain the 6th filtrate and the 6th filtering residue；
Step 5, take the Herba Cistanches of above-mentioned weight portion, Radix Panacis Quinquefolii, Radix Notoginseng, Stigma Croci and the Cortex Eucommiae, be added into the 6th filtrate
In, it is 1.3 that ultrasound wave dispersion is evaporated to relative density after extracting, and obtains the 3rd thick paste；
Step 6, merge the first thick paste, the second thick paste and the 3rd thick paste, and mix homogeneously.
The preparation method of described dredging cardiovascular drugs, also includes after described step 6:
Step 7, add pharmaceutically acceptable adjuvant, prepared by the first thick paste, the second thick paste and the 3rd thick paste after merging
Become electuary, tablet or capsule.
The preparation method of described dredging cardiovascular drugs, in described step 2, volume fraction is ethanol and the round trip flight butterfly of 55%
The weight ratio of butterfly and Sassafras tsumu Hemsl. is 10:1, and water is 10:1 with the weight ratio of described first filtering residue, and hyperpressure extraction condition is: pressure
Power 700MPa, extraction time 8min.
The preparation method of described dredging cardiovascular drugs, in described step 3, volume fraction be 90% ethanol and Rhizoma Chuanxiong,
The weight ratio of Radix Polygalae and Radix Salviae Miltiorrhizae is 15:1, and volume fraction is the ethanol of 55% and the weight ratio of described 3rd filtering residue is 15:1, water
Weight ratio in described 4th filtering residue is 12:1, and reflux, extract, condition is: Extracting temperature 60 DEG C, reflow's cycle 3 times, often
Secondary return time 1h.
The preparation method of described dredging cardiovascular drugs, in described step 4, water and described Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Clematidis, mountain
The weight ratio of Fructus Evodiae meat and Rhizoma Anemones Altaicae is 20:1, and reflux, extract, condition is: Extracting temperature 80 DEG C, reflow's cycle 3 times,
Return time 1.5h every time.
The preparation method of described dredging cardiovascular drugs, in described step 5, ultrasound wave dispersion extraction conditions is: ultrasound wave
Power 500W, ultrasonic number of times 6 times, adjacent twice ultrasonic interval time 25min, wherein, for the first time and second time is the most ultrasonic
Ultrasonic time 15min every time, from third time ultrasonic beginning each ultrasonic time 10min.
Model case:
Case 1: plant certain, female, 76 years old, the most dizzy, headache, treatment front CT diagnosis report display basal ganglia region, both sides,
Thalamus district lacunar infarction, senile encephalatrophy, take the medicine of the present invention, after 3 days, dizzy, headache symptom is obvious
Alleviating, after taking medicine 45 days, symptom all disappears, and the check CT display each tremulous pulse of brain shows clear, and blood vessel wall is the most smooth,
Show no obvious abnormalities.
Case 2: clock, man, 59 years old, suffer from coronary heart disease 2 years, frequent chest pain, uncomfortable in chest, insomnia, carry out stent-expansion art
After, symptom has no improvement, takes the medicine of the present invention, and after 5 days, symptom is wholly absent, and recovers normal.
Case 3: why certain, man, 52 years old, frequent chest pain, uncomfortable in chest, before treatment, electrocardiogram diagnosis report display cardiovascular is serious
Blocking, hospital's suggestion carries out stent-expansion art, but due to financial difficulties, abandons operation, change the medicine taking the present invention, clothes
After medicine 3 months, chest pain, symptom uncomfortable in chest are wholly absent, and electrocardiographic diagnosis report display blood vessel is the most unimpeded, and physician declared holds
Recognize miracle, exempt stent-expansion art.
Case 4: Liu, female, 55 years old, suffers from hypertension 8 years, takes FUFANG DANSHEN PIAN and brain blood open capsule the most always
Maintaining blood pressure stabilization, owing to taking antihypertensive drugs always, Liu has occurred the abnormal liver function such as weak, nauseating, loss of appetite
Situation, takes medicine of the present invention, after 10 days, the remission such as weak, nauseating, loss of appetite, continued medication to 30 days
After, blood pressure stabilization, the symptom such as weak, nauseating, loss of appetite is wholly absent, and after continuing to strengthen treatment 30 days, drug withdrawal is seen
Examining, blood pressure stabilization, have no rising, pay a return visit after 3 months, blood pressure is constantly in normal range, and health all goes well.
Case 5: Dong, female, 40 years old, burst cerebral hemorrhage was admitted to hospital after operative treatment, leaves sequela, and left side health is stiff,
Imperception, it is impossible to move, frequent sialorrhea, gatism, need special messenger to nurse, take medicine of the present invention after 5 days, left
Limit health energy perception pain, has limp and numb sense, and after taking medicine 10 days, left hand and left lower limb can be moved, after taking medicine 30 days, and can sustaining wall
Activity, life can be taken care of oneself, and after taking medicine continuously 80 days, it is possible to independent ambulation, thoroughly cures, and pays a return visit, health after 3 months
All go well, have no recurrence.
Although embodiment of the present invention are disclosed as above, but it is not restricted in description and embodiment listed fortune
With, it can be applied to various applicable the field of the invention completely, for those skilled in the art, and can be easily
Realizing other amendment, therefore under the general concept limited without departing substantially from claim and equivalency range, the present invention does not limit
In specific details.
Claims (9)
1. a dredging cardiovascular drugs, it is characterised in that be mainly made up of following raw material by weight: Sassafras tsumu Hemsl.
1-3 part, Herba Christiae 1-3 part, Radix Salviae Miltiorrhizae 1-5 part, Cortex Eucommiae 1-5 part, Rhizoma Anemones Altaicae 1-3 part, Fructus Corni officinalis 1-3 part,
Rhizoma Chuanxiong 1-3 part, Radix Angelicae Sinensis 1-3 part, Radix Glycyrrhizae 1-3 part, Radix Clematidis 1-3 part, Herba Cistanches 1-5 part, Radix Panacis Quinquefolii 1-5 part, Radix Notoginseng
1-5 part, Stigma Croci 1-3 part and Radix Polygalae 1-3 part.
Dredge cardiovascular drugs the most as claimed in claim 1, it is characterised in that mainly the most former by by weight
Material is made: Sassafras tsumu Hemsl. 2 parts, Herba Christiae 2 parts, Radix Salviae Miltiorrhizae 3 parts, the Cortex Eucommiae 3 parts, Rhizoma Anemones Altaicae 2 parts, Fructus Corni officinalis 2
Part, Rhizoma Chuanxiong 2 parts, Radix Angelicae Sinensis 2 parts, 2 parts of Radix Glycyrrhizae, Radix Clematidis 2 parts, Herba Cistanches 3 parts, Radix Panacis Quinquefolii 3 parts, Radix Notoginseng 3 parts,
Stigma Croci 2 parts and Radix Polygalae 2 parts.
Dredge cardiovascular drugs the most as claimed in claim 1, it is characterised in that described Radix Salviae Miltiorrhizae is Radix Salviae Miltiorrhizae (processed with wine)；Described
The Cortex Eucommiae is Cortex Eucommiae (processed with salt)；Described Radix Polygalae is processed with honey Radix Polygalae.
4. the preparation method of the dredging cardiovascular drugs as described in claim 1-3 is arbitrary, it is characterised in that include
Following steps:
Step one, Herba Cistanches by prescription, Radix Panacis Quinquefolii, Radix Notoginseng, Stigma Croci and Cortex Eucommiae micronizing respectively is to 500-700
Mesh, remaining component in prescription is crushed to 80-100 mesh respectively；
Step 2, the Herba Christiae taking above-mentioned weight portion and Sassafras tsumu Hemsl., after mix homogeneously, be 40-55%'s through volume fraction
Ethanol hyperpressure extraction, obtains the first filtrate and the first filtering residue, by described first filtering residue through water hyperpressure extraction, obtains the second filtrate
With the second filtering residue, merging the first filtrate and the second filtrate, being evaporated to relative density is 1.2-1.3, obtains the first thick paste；
Step 3, take the Rhizoma Chuanxiong of above-mentioned weight portion, Radix Polygalae and Radix Salviae Miltiorrhizae, after mix homogeneously, be 85-90%'s through volume fraction
Alcohol reflux, obtains the 3rd filtrate and the 3rd filtering residue, is returned through the ethanol that volume fraction is 40-55% by described 3rd filtering residue
Stream extracts, and obtains the 4th filtrate and the 4th filtering residue, by described 4th filtering residue through water reflux, extract, obtains the 5th filtrate and the 5th filtering residue,
Merging the 3rd filtrate, the 4th filtrate and the 5th filtrate, being evaporated to relative density is 1.2-1.3, obtains the second thick paste；
Step 4, take the Radix Angelicae Sinensis of above-mentioned weight portion, Radix Glycyrrhizae, Radix Clematidis, Fructus Corni officinalis and Rhizoma Anemones Altaicae, through water reflux, extract,
Obtain the 6th filtrate and the 6th filtering residue；
Step 5, take the Herba Cistanches of above-mentioned weight portion, Radix Panacis Quinquefolii, Radix Notoginseng, Stigma Croci and the Cortex Eucommiae, be added into the 6th filtrate
In, it is 1.2-1.3 that ultrasound wave dispersion is evaporated to relative density after extracting, and obtains the 3rd thick paste；
Step 6, merge the first thick paste, the second thick paste and the 3rd thick paste, and mix homogeneously.
5. the as claimed in claim 4 preparation method dredging cardiovascular drugs, it is characterised in that described step 6 it
After also include:
Step 7, add pharmaceutically acceptable adjuvant, prepared by the first thick paste, the second thick paste and the 3rd thick paste after merging
Become electuary, tablet or capsule.
6. the preparation method dredging cardiovascular drugs as claimed in claim 4, it is characterised in that in described step 2,
Volume fraction is ethanol and the Herba Christiae of 40-55% and the weight ratio of Sassafras tsumu Hemsl. is 5-10:1, water and described first filtering residue
Weight ratio is 5-10:1, and hyperpressure extraction condition is: pressure 600-700MPa, extraction time 5-8min.
7. the preparation method dredging cardiovascular drugs as claimed in claim 4, it is characterised in that in described step 3,
Volume fraction be the weight ratio of ethanol and the Rhizoma Chuanxiong of 85-90%, Radix Polygalae and Radix Salviae Miltiorrhizae be 10-15:1, volume fraction is 40-55%
The weight ratio of ethanol and described 3rd filtering residue be 10-15:1, water is 8-12:1 in the weight ratio of described 4th filtering residue, and backflow carries
The condition of taking is: Extracting temperature 50-60 DEG C, reflow's cycle 2-3 time, each return time 0.5-1h.
8. the preparation method dredging cardiovascular drugs as claimed in claim 4, it is characterised in that in described step 4,
Water is 15-20:1 with the weight ratio of described Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Clematidis, Fructus Corni officinalis and Rhizoma Anemones Altaicae, and reflux, extract, condition is:
Extracting temperature 70-80 DEG C, reflow's cycle 2-3 time, each return time 1-1.5h.
9. the preparation method dredging cardiovascular drugs as claimed in claim 4, it is characterised in that in described step 5,
Ultrasound wave dispersion extraction conditions is: ultrasonic power 400-500W, ultrasonic number of times 4-6 time, during adjacent twice ultrasonic interval
Between 20-25min, wherein, for the first time and the ultrasonic each ultrasonic time 12-15min of second time, every from the ultrasonic beginning of third time
Secondary ultrasonic time 8-10min.
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| CN106421603A (en) * | 2016-10-26 | 2017-02-22 | 黔西南州神力中草药应用开发研究所 | Medicine for treating cardiovascular disease and preparation method thereof |
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| CN102940833A (en) * | 2012-10-10 | 2013-02-27 | 肥西县中医院 | Traditional Chinese medicine composition for treating coronary heart disease and preparation method thereof |
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| CN102940833A (en) * | 2012-10-10 | 2013-02-27 | 肥西县中医院 | Traditional Chinese medicine composition for treating coronary heart disease and preparation method thereof |
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| CN106421603A (en) * | 2016-10-26 | 2017-02-22 | 黔西南州神力中草药应用开发研究所 | Medicine for treating cardiovascular disease and preparation method thereof |
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