CN1943712A - A Chinese traditional medicinal composition for treatment of astriction and its preparation method - Google Patents
A Chinese traditional medicinal composition for treatment of astriction and its preparation method Download PDFInfo
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- CN1943712A CN1943712A CN 200510105953 CN200510105953A CN1943712A CN 1943712 A CN1943712 A CN 1943712A CN 200510105953 CN200510105953 CN 200510105953 CN 200510105953 A CN200510105953 A CN 200510105953A CN 1943712 A CN1943712 A CN 1943712A
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- 238000002360 preparation method Methods 0.000 title claims description 6
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- 238000003756 stirring Methods 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 239000003814 drug Substances 0.000 claims description 21
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- 239000008187 granular material Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 6
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 244000025254 Cannabis sativa Species 0.000 abstract 1
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 abstract 1
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 abstract 1
- 244000183685 Citrus aurantium Species 0.000 abstract 1
- 235000007716 Citrus aurantium Nutrition 0.000 abstract 1
- 235000005976 Citrus sinensis Nutrition 0.000 abstract 1
- 244000088415 Raphanus sativus Species 0.000 abstract 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 235000009120 camo Nutrition 0.000 abstract 1
- 235000005607 chanvre indien Nutrition 0.000 abstract 1
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- HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 229960004192 diphenoxylate Drugs 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
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- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
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- 210000001809 melena Anatomy 0.000 description 1
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- 239000000243 solution Substances 0.000 description 1
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- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
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Abstract
This invention provides a Chinese traditional medicinal composition for treatment of infant astriction. The composition is prepared by using desertliving cistanche herb, hemp fimble seed, Chinese angelica root, radix ophioponis, seville orange fruit, radish seed (stir fried), ningpo figword root and astragalus root in accordance with a certain preparing technology. The invention also reveals preparing method.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of functional constipation and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Infantile constipation is meant that the infant stool abnormity is stiff, can be when causing the infant defecation of difficult defecation because of the proctalgia uneasiness of crying and screaming, and diseases such as spirit, appetite are bad, abdominal distention also can appear in the children's of constipation in many days.Constipation not only brings misery to children's, give father and mother also bring the utmost point a peace and worried.The reason that causes constipation is a lot, and generally speaking, constipation is mainly relevant with the growth and the motive force of the quality and quantity of feeding patterns, diet, bowl evacuation habit, pipe intestinal digesting absorbability, abdominal muscle pressure, intestinal smooth muscle.The artificial feeding infant is than the easy constipation of breast feeding, and this is because contain more calcium and casein in the milk, and sugar and starch content reduces relatively, eats the easy calcium soap that forms in back to cause constipation; Life does not have rule, and the baby is not trained to the custom of defecation on time, and also easily this plays constipation; Some chronic disease such as rickets, dermatomyositis etc. cause malnutrition also vigour cause constipation.Therefore, it is very necessary to explore a kind of medicine for the treatment of infantile constipation.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of constipation and preparation method thereof for preparing.
The present invention seeks to be achieved through the following technical solutions:
At first be that prescription is formed, comprise following bulk drugs:
Herba Cistanches 100～300 weight portion Fructus Cannabiss 100～200 weight portion Radix Angelicae Sinensis 100～200 weight portions
Radix Ophiopogonis 50～150 weight portion Fructus Aurantiis, 50～150 weight portion Semen Raphanis (stir-fry), 50～150 weight portions
Radix Scrophulariae 50～150 weight portion Fructus Gardeniaes 50～150 weight portions
Further after the research, determine that its best group becomes:
Herba Cistanches 200 weight portion Fructus Cannabiss 150 weight portion Radix Angelicae Sinensis 150 weight portions
Radix Ophiopogonis 100 weight portion Fructus Aurantiis, 100 weight portion Semen Raphanis (stir-fry), 100 weight portions
Radix Scrophulariae 100 weight portion Fructus Gardeniaes 100 weight portions
Should write out a prescription, invention is thought can make clinical required oral liquid, granule, tablet, capsule.Be directed to this, the inventor has carried out technical study again.Its process is as follows:
Get crude drug, add 10 times of amounts of water and decoct secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, filtrate is concentrated into the clear paste that relative density is 1.20～1.25 (70～80 ℃), put coldly, add ethanol and make that to contain alcohol amount be 65%, fully stir, leave standstill, divide and get supernatant, reclaim ethanol to there not being the alcohol flavor, promptly.
The specific embodiment:
Medicine of the present invention is applicable to functional constipation.The inventor cures mainly according to its function, from the loosening bowel to relieve constipation aspect its pharmacodynamics is verified.
Medicine infantile constipation Chinese medicine, self-control.
R-1132 (causing emplastic): Wujin, city, Wujin, Jiangsu pharmaceutical factory produces, specification 2.5mg/ sheet.
The animal Kunming mouse, body weight 18～22g, the male and female dual-purpose is provided by laboratory animal portion of Medical School of Peking University.
Method
The defecation influence of 1 pair of normal mouse of test
40 of normal mouses, fasting 6h, be divided into 4 groups at random, every group 10, each group respectively with high (8ml/kg), in (4ml/kg), the secret logical oral liquid of low (2ml/kg) dosage children's (dilution be 10ml respectively, down with) and normal saline filling stomach, observe every animal 7h fecal grains after the administration continuously, stool weight, adopts the relatively difference of each treated animal These parameters of t check at the 1st discharge melena time.
The influence of table 1 pair normal mouse defecation (X ± s)
| Group | Number of animals (only) | Defecation time (min) | Fecal grains | Stool weight (mg) |
| Dosage group high dose group in the normal saline low dose group | 10 10 10 10 | 32.1±4.92 30.2±5.01 25.5±5.46 20.8±4.62 | 3.5±3.54 5.2±1.32 5.9±2.10 7.1±1.86 | 43.2±23.1 55.6±25.4 62.5±22.7 72.1±24.8 |
Annotate: compare P＜0.05 with the normal saline group.
Test 2 antagonism diphenoxylates suppress intestinal progradation test
50 male and female dual-purposes of mice are divided into 5 groups at random, and 10 every group, according to dosage method for designing was fed 25 days continuously.Behind day fasting 12h of end, A group normal saline, C, D, E group are irritated stomach 1 time with basic, normal, high dosage Chinese medicine oral liquid, and behind the 20min, B, C, D, E group are irritated stomach with diphenoxylate 50mg/kg, and each group is pressed 0.1ml/10g with charcoal end suspension and is irritated stomach behind the 10min.Behind the 20min abdomen is opened in mice execution, got small intestinal, measure the charcoal end and advance length and small intestinal total length, calculate the last mobility that advances of charcoal.
Prepared Chinese ink propelling rate=prepared Chinese ink advances length (cm)/small intestinal total length (cm) * 100%
Table 2 antagonism diphenoxylate suppresses intestinal progradation effect
| Group | Number of animals (only) | Carbon powder propelling rate (%) |
| Dosage group E high dose group among the A normal control group B diphenoxylate matched group C low dose group D | 10 10 10 10 10 | 32.1±4.92 30.2±5.01 25.5±5.46 20.8±4.62 |
Annotate: compare P＜0.05 with the diphenoxylate matched group.
Embodiment one
[prescription] Herba Cistanches 200g Fructus Cannabis 150g Radix Angelicae Sinensis 150g
100g Fructus Aurantii 100g Semen Raphani Radix Ophiopogonis (stir-fry) 100g
Radix Scrophulariae 100g Fructus Gardeniae 100g
[method for making] gets crude drug, and add 10 times of amounts of water and decoct secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.20～1.25 (70～80 ℃), puts cold, add ethanol and make that to contain alcohol amount be 65%, fully stir, leave standstill, divide and get supernatant, reclaim ethanol to there not being the alcohol flavor, add sucrose 100g, Mel 225g, steviosin 3g, adjust pH to 5.0～7.0 add water to 1000ml, mixing leaves standstill, and filters, fill, sterilization, promptly.
Embodiment two
[prescription] Herba Cistanches 400g Fructus Cannabis 300g Radix Angelicae Sinensis 300g
200g Fructus Aurantii 200g Semen Raphani Radix Ophiopogonis (stir-fry) 200g
Radix Scrophulariae 200g Fructus Gardeniae 200g
[method for making] gets crude drug, adds 10 times of amounts of water and decocts secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, filtrate is concentrated into the clear paste that relative density is 1.20～1.25 (70～80 ℃), puts coldly, adds ethanol and makes that to contain alcohol amount be 65%, fully stir, leave standstill, divide and get supernatant, reclaim ethanol to there not being the alcohol flavor, being concentrated into relative density is 1.10 (60 ℃), spray drying, with sucrose to total amount is 1000g, and dry-pressing is granulated, promptly.
Claims (5)
1. Chinese medicine composition is characterized in that this pharmaceutical composition made by following raw material medicaments:
Herba Cistanches 100～300 weight portion Fructus Cannabiss 100～200 weight portion Radix Angelicae Sinensis 100～200 weight portions
Radix Ophiopogonis 50～150 weight portion Fructus Aurantiis, 50～150 weight portion Semen Raphanis, 50～150 weight portions
Radix Scrophulariae 50～150 weight portion Fructus Gardeniaes 50～150 weight portions
2. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw materials according:
Herba Cistanches 200 weight portion Fructus Cannabiss 150 weight portion Radix Angelicae Sinensis 150 weight portions
Radix Ophiopogonis 100 weight portion Fructus Aurantiis, 100 weight portion Semen Raphanis, 100 weight portions
Radix Scrophulariae 100 weight portion Fructus Gardeniaes 100 weight portions
3. Chinese medicine composition as claimed in claim 1 is characterized in that said composition can be made into clinical required oral liquid, granule, tablet, capsule.
4. the preparation method of Chinese medicine composition as claimed in claim 1 is characterized in that preparing as follows: get crude drug, decoct with water 1-3 time, each 1-3 hour, collecting decoction filtered, it is 1.20～1.25 clear paste that filtrate is concentrated in the time of 70～80 ℃ relative density, put coldly, add ethanol and make the alcohol amount of containing be 60-70%, fully stir, leave standstill, divide and get supernatant, reclaim ethanol to there not being the alcohol flavor, promptly.
5. the preparation method of Chinese medicine composition as claimed in claim 1 is characterized in that preparing as follows: get crude drug, add 10 times of amounts of water and decoct secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, it is 1.20～1.25 clear paste that filtrate is concentrated in the time of 70～80 ℃ relative density, puts cold, add ethanol and make that to contain alcohol amount be 65%, fully stir, leave standstill, divide and get supernatant, reclaim ethanol to there not being the alcohol flavor, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005101059535A CN1943712B (en) | 2005-10-08 | 2005-10-08 | A Chinese traditional medicinal composition for treatment of astriction and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005101059535A CN1943712B (en) | 2005-10-08 | 2005-10-08 | A Chinese traditional medicinal composition for treatment of astriction and its preparation method |
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| Publication Number | Publication Date |
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| CN1943712A true CN1943712A (en) | 2007-04-11 |
| CN1943712B CN1943712B (en) | 2011-12-14 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940621A (en) * | 2010-05-28 | 2011-01-12 | 中国人民解放军总医院 | Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof |
| CN103053905A (en) * | 2013-01-16 | 2013-04-24 | 无限极（中国）有限公司 | Health-care food with constipation improvement function |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1035802C (en) * | 1992-06-15 | 1997-09-10 | 中国人民解放军空军南京医院 | Constipation medicine "shenshenwan" |
| CN1045060C (en) * | 1993-05-29 | 1999-09-15 | 陆国钧 | Laxative Chinese medicine capable of lowering level of human free radical |
| CN1058903C (en) * | 1999-01-15 | 2000-11-29 | 陆国钧 | Chinese-medicine and without laxative for relaxing bowels |
| CN1116063C (en) * | 2000-09-14 | 2003-07-30 | 浙江省中药研究所 | Chinese medicine for nourishing yin and treating constipation |
| CN1481870A (en) * | 2003-07-24 | 2004-03-17 | 黄资源 | Compound traditional Chinese medicine preparation for treating intractable chronic constipation and preparation method thereof |
-
2005
- 2005-10-08 CN CN2005101059535A patent/CN1943712B/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940621A (en) * | 2010-05-28 | 2011-01-12 | 中国人民解放军总医院 | Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof |
| CN101940621B (en) * | 2010-05-28 | 2011-12-28 | 中国人民解放军总医院 | Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof |
| CN103053905A (en) * | 2013-01-16 | 2013-04-24 | 无限极（中国）有限公司 | Health-care food with constipation improvement function |
| CN103053905B (en) * | 2013-01-16 | 2014-01-29 | 无限极（中国）有限公司 | Health-care food with constipation improvement function |
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| Publication number | Publication date |
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| CN1943712B (en) | 2011-12-14 |
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Inventor after: Fu Shangda Inventor before: Liu Guofei |
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Effective date of registration: 20151214 Address after: 150086 No. 408, Xuefu Road, Xiangfang District, Heilongjiang, Harbin Patentee after: Harbin Yizhou Pharmaceutical Co., Ltd. of Yuanda Pharmaceutical Group Address before: 100012, No. 10, Qinglong dragon alley, Dongcheng District, Beijing Patentee before: Liu Guofei |
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Address after: The 150066 auspicious clouds in Heilongjiang Province Economic and Technological Development Zone of Harbin District A Hanan Industrial Park Road No. 1 Patentee after: Harbin Yizhou Pharmaceutical Co., Ltd. of Yuanda Pharmaceutical Group Address before: 150086 No. 408, Xuefu Road, Xiangfang District, Heilongjiang, Harbin Patentee before: Harbin Yizhou Pharmaceutical Co., Ltd. of Yuanda Pharmaceutical Group |