CN103053905B - Health-care food with constipation improvement function - Google Patents
Health-care food with constipation improvement function Download PDFInfo
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- CN103053905B CN103053905B CN201310015844.9A CN201310015844A CN103053905B CN 103053905 B CN103053905 B CN 103053905B CN 201310015844 A CN201310015844 A CN 201310015844A CN 103053905 B CN103053905 B CN 103053905B
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Abstract
The invention discloses a health-care food with a constipation improvement function. The health-care food is prepared from the following active components in parts by weight: 50-300 parts of radix scrophulariae, 50-300 parts of astragalus mongholicus, 25-250 parts of radix ophiopogonis, 25-250 parts of radish seed, 15-200 parts of folium sennae and 10-200 parts of stachyose. The health-care food has the characteristics that the traditional Chinese medicine herbs are combined with the modern medical research, and various components are reasonably combined and prepared, so as to achieve the health-care function of constipation improvement in multiple ways and multiple levels.
Description
Technical field
The present invention relates to a kind of health food, relating in particular to a kind of is the health food with bowel relaxing functions that primary raw material is made by Chinese herbal medicine.
Background technology
Constipation refers to that constipation is obstructed, and ight soil was detained of a specified duration in intestines, defecation cycle stretch-out, or excrement matter is dry and hard, and it is difficult to discharge, or wish is defecated and involved and abstruse not smooth a kind of clinical symptoms.Long-term constipation meeting brings huge misery to patient, increases the weight of patient's mental burden, increases anxiety and tense mood, and human internal environment, internal system are all had a certain impact, and with the passing of time also may bring out or increase the weight of the quality of life that Other diseases affects patient.
Modern medicine thinks that the main cause that constipation occurs has: food or the hypohydration 1. taken in, and make the amount of chyme residue in intestines or ight soil also few, be not enough to stimulate the normal creepage of gastrointestinal functions of colon.2. the wriggle weakness of enteron aisle or enteron aisle muscle tone lower.3. enteric cavity has narrow or blocks existence, and normal enterocinesia is obstructed, and causes the ight soil can not the row of descending, for example intestinal obstruction or proportion of cancer of left side of colon.When any link has obstacle or pathology in 4. defecation reflex process, all can there is constipation, the decreased sensation of rectal mucosa mechanical irritation for example, pelvic cavity is neural, waist sacral spinal cord DPN, sphincterismus, abdominal muscle and contraction of diaphragm hypomotility etc.
Along with growth in the living standard, the change of dietary structure, the minimizing that the materials such as dietary fiber are taken in, the suffered stimulation of enteron aisle declines, and causes enteron aisle to shrink and slows down, and contraction dynamics reduces, and causes difficult defecation, and there is chronicity, habitual constipation in severe patient.Constipation in recent years becomes one of city resident's common disease gradually, and constipation crowd's the health food for bowel relaxing functions of increasing also provides the huge market space.In China, the incidence of disease of constipation is the gesture of rapid growth recent years.Relevant investigation result demonstration, in Beijing, Tianjin and the 60 years old above crowd in area, Xi'an, chronic constipation illness rate is up to 15%～20%.In the adult of Beijing area, chronic constipation illness rate is approximately 6% left and right, and wherein women's illness rate is approximately the more than 4 times of the male sex, and the age of constipation patient develops to rejuvenation just gradually.
Summary of the invention
The object of the present invention is to provide a kind of is the health food with bowel relaxing functions that primary raw material is made by Chinese herbal medicine, the various composition reasonable formula of this health food, coordinate to share, by number of ways, reach at many levels the health care of defaecation.
The health food with bowel relaxing functions provided by the invention is prepared from by the active component of following weight parts proportioning: radix scrophulariae 50～300, the Radix Astragali 50～300, the tuber of dwarf lilyturf 25～250, radish seed 25～250, folium sennae 15～200, stachyose 10～200.
Preferred weight part proportioning of the active component of preparation health food of the present invention is: radix scrophulariae 80～120, the Radix Astragali 80～120, the tuber of dwarf lilyturf 50～100, radish seed 50～100, folium sennae 50～100, stachyose 80～120.
Optimum weight part proportioning of the active component of preparation health food of the present invention is: radix scrophulariae 100, the Radix Astragali 100, the tuber of dwarf lilyturf 75, radish seed 75, folium sennae 75, stachyose 100.
The above-mentioned health food with bowel relaxing functions, by conventional formulation technique (as water extraction is got or alcohol extracting etc.), can make said multiple formulation in pharmacy, as oral liquid, capsule, tablet, pulvis, beverage, mixture or granule etc.
The traditional Chinese medical science thinks, its sick position of constipation is at large intestine, not normal by large intestine conduction function, due to internal organs, body fluid, insufficiency of vital energy and blood, but very close with the relation of lung, taste and kidney.The lung and the large intestine being interior-exteriorly related, it is respectful that lung loses a surname, and internal organs gas is stopped up stagnant, and body fluid is cloth not, and Lung Qi deficiency promotes unable, and large intestine transmits unable; The dysfunction of the spleen in transport, stops in waste matter, strongly fragrant of a specified durationization fire, and consumption is hindered body fluid; Deficiency of the kidney is warm haves no right, and can not evaporate the gentle enteron aisle of body fluid; Deficiency of blood enteron aisle loses to grow and loses profit; Body fluid deficiency, and the anhydrous factors of sailing a boat causes large intestine conduction dereliction of duty, and causes constipation.
Health food of the present invention is according to the achievement in research of Traditional Chinese medical theory and modern pharmacology, select radix scrophulariae, the Radix Astragali, the tuber of dwarf lilyturf, radish seed, folium sennae and stachyose prescription to form, in side, reuse radix scrophulariae nourishing Yin and promoting production of body fluid, clearing heat and moistening dryness and defaecation, for monarch drug in a prescription, Radix Astragali bowl spares gas, strengthening the spleen and stomach and short transporting, stomach transporting, passing to such an extent that take charge of constipation and can lead to, is ministerial drug; The tuber of dwarf lilyturf is nourshing Yin and drynsessmoistening prescription, replenishing the vital essence and removing heat, with radix scrophulariae mutual reinforcement between in order to increase enteron aisle body fluid, moist large intestine; Semen Raphani in Moving qi and Removing Food Retention, invigorating the spleen and stomach can amass in helping digestion, and dissipate-swelling is full; Folium sennae is purged heat capable stagnant, defaecation, and all medicines share, and play altogether tonifying Qi enriching yin, the merit of clearing away heat and moistening the bowels.Add on this basis stachyose, improve environment in human body alimentary canal, regulate micro-ecological bacterial group balance.All medicines are harmonious, and reach the effect of defaecation.
The feature of health food of the present invention is that to take radix scrophulariae, the Radix Astragali, the tuber of dwarf lilyturf, radish seed, five kinds of Chinese herbal medicines of folium sennae and stachyose be primary raw material, makes various composition reasonable formula, coordinates and share, by number of ways, reach at many levels the health care of defaecation.
Below by the specific embodiment and pharmacodynamic study result, the invention will be further described.
The specific embodiment
The present invention will be described to enumerate a part of specific embodiment below, is necessary to be pointed out that at this following specific embodiment, only for the invention will be further described, does not represent limiting the scope of the invention.Some nonessential modifications that other people make according to the present invention and adjustment still belong to protection scope of the present invention.
Embodiment 1
The health food with defecating feces excretion that the embodiment of the present invention 1 provides is prepared from by the active component of following weight proportioning: radix scrophulariae 100, the Radix Astragali 100, the tuber of dwarf lilyturf 75, radish seed 75, folium sennae 75, stachyose 100.
Embodiment 2
The health food with defecating feces excretion that the embodiment of the present invention 2 provides is prepared from by the active component of following weight proportioning: radix scrophulariae 120, the Radix Astragali 150, the tuber of dwarf lilyturf 90, radish seed 75, folium sennae 60, stachyose 120.
Embodiment 3
The health food with defecating feces excretion that the embodiment of the present invention 3 provides is prepared from by the active component of following weight proportioning: radix scrophulariae 150, the Radix Astragali 150, the tuber of dwarf lilyturf 100, radish seed 90, folium sennae 75, stachyose 100.
Embodiment 4
The health food with defecating feces excretion that the embodiment of the present invention 4 provides is prepared from by the active component of following weight proportioning: radix scrophulariae 80, the Radix Astragali 120, the tuber of dwarf lilyturf 90, radish seed 60, folium sennae 80, stachyose 90.
Embodiment 5
The health food with defecating feces excretion that the embodiment of the present invention 5 provides is prepared from by the active component of following weight proportioning: radix scrophulariae 130, the Radix Astragali 130, the tuber of dwarf lilyturf 100, radish seed 90, folium sennae 90, stachyose 90.
Embodiment 6
The health food with defecating feces excretion that the embodiment of the present invention 6 provides is prepared from by the active component of following weight proportioning: radix scrophulariae 110, the Radix Astragali 80, the tuber of dwarf lilyturf 50, radish seed 60, folium sennae 30, stachyose 50.
Embodiment 7
The health food with defecating feces excretion that the embodiment of the present invention 7 provides is prepared from by the active component of following weight proportioning: radix scrophulariae 100, the Radix Astragali 80, the tuber of dwarf lilyturf 60, radish seed 50, folium sennae 50, stachyose 80.
In above embodiment, each component is commercial goods, by conventional formulation technique (as water extraction is got or alcohol extracting etc.), can make said multiple formulation in pharmacy, as oral liquid, capsule, tablet, pulvis, beverage, mixture or granule etc.
Pharmacodynamic study
The raw material composition and ratio that applicant uses above-described embodiment 1 to provide, the health food with bowel relaxing functions by conventional formulation technique gained has carried out effect demonstration test, and result of the test is as follows:
1. test unit
Life Science College medicine Molecular Biology Lab of Zhongshan University
2. experiment purpose
Study the function that health food of the present invention has defaecation.
3. experiment material
Health food of the present invention: defaecation sample 1(oral liquid), by providing without thresold (China) Co., Ltd, outward appearance is brown liquid, and the oral recommended amounts of human body is that 10ml/ props up, each 1, every day 2 times, with everyone 60kg body weight, calculate, amount to dosage 0.5ml/kg.bw.Sample thief stoste is standby.
4. dosage setting
Table 1 is by body weight conversion dosage
Dosage design considerations: it is 1.7ml/kg, 3.3ml/kg, 10ml/kg that the basic, normal, high dosage group of sample 1 mouse gives respectively dosage, converts and is equivalent to 5 times, 10 times, 30 times of 60kg adult's dose about 20ml/ day by body weight; Green source of students control group adult taking dose is 5g/ day, and by 2 tea bag bags, with the hot-water soak of 50ml after 3 hours, mouse dosage is 8.3ml/kg soak, by body weight, converts 10 times that are equivalent to that 60kg Coming-of-Age Day consumption is 5g.
5. experimental technique
Choose healthy male KM mouse, body weight 18-22g, is divided into 9 groups at random, i.e. the low middle high dose group of Normal group, model control group, sample 1 and green source of students control group, every group of 12 mouse; Except green source of students control group, all the other respectively organize mouse successive administration 7 days; Green source of students control group a few days ago starts administration in experiment; Before each organizes mouse experiment, fasting be can't help water 16 hours.
Before experiment, preparation prepared Chinese ink, accurately takes gum arabic 100g, adds water 800ml, boils to solution transparently, takes activated carbon powder 50g and adds in above-mentioned solution and boil three times, adds water constant volume to 1000ml after solution is cool, and 4 ℃ of preservations in refrigerator, with front shaking up.Preparation compound diphenoxylate suspension before experiment, concentration is 0.05%, R-1132, every containing 2.5mg compound diphenoxylate.Get R-1132 50mg(20 sheet), after grinding with mortar, adding distil water, to 100ml, is prepared before use.
When experiment starts, Normal group gives pure water, model control group and other administration group gavage give compound diphenoxylate 5mg/kg, give after 0.5h, each organizes the prepared Chinese ink (containing 5% activated carbon and 10% gum arabic) that mouse stomach contains given the test agent, the single cage of animal is raised, normal drinking-water feed.From filling with prepared Chinese ink, record every first grain of animal and arrange melena grain number and weight in row's melena time, 5 hours.Carry out statistical procedures and compare group difference.
6. experimental result
By table 2 experimental result, can be obtained, mouse gives after compound diphenoxylate model control group group, defecation time obviously extends, fecal grains and stool weight in 5 hours obviously reduce, with the same period Normal group compare, have significant difference (P<0.001), prompting Constipation Model is successfully prepared.The low middle high dose group of sample 1 can shorten the defecation time that gives compound diphenoxylate mouse to some extent, increase fecal grains and the weight of mouse discharge in 5 hours, with the same period model control group compare, there is significant difference (P<0.05, P<0.01, P<0.001); Prompting thus: each dosage group of given the test agent has good functions of loosening bowel relieving constipation to mice with constipation, and presents dose-effect relationship.Green source of students control group is because meeting causes the laxativeness of mouse, historical facts or anecdotes is tested a few days ago just administration, in experiment, find that mouse occurs just rotten, formability is poor, therefore in 6 hours, fecal grains reduces on the contrary and is difficult to take out and weighs, therefore cause fecal grains and weight with the same period model control group compare, there was no significant difference (P>0.05); But the first pellet efflux time just or obviously shorten, with the same period model control group compare, there is significant difference (P<0.05), point out its to the functions of loosening bowel relieving constipation effect of mice with constipation a little less than.In sum, the defaecation situation that 1 pair, sample improves mice with constipation presents good action effect, and the soft durometer of ight soil is applicable, and formability is good, mouse state and Normal group no significant difference.
Table 2 given the test agent to the bowel movement function experimental result of compound diphenoxylate Constipation Model mouse (
n=12)
Note: with the model control group comparison same period
*p<0.05,
*p<0.01,
* *p<0.001.
Claims (4)
1. a health food with bowel relaxing functions, is characterized in that: this health food is prepared from by the active component of following weight parts proportioning: radix scrophulariae 50～300, the Radix Astragali 50～300, the tuber of dwarf lilyturf 25～250, radish seed 25～250, folium sennae 15～200, stachyose 10～200.
2. the health food with bowel relaxing functions according to claim 1, is characterized in that: the weight portion proportioning of each active component is: radix scrophulariae 80～120, the Radix Astragali 80～120, the tuber of dwarf lilyturf 50～100, radish seed 50～100, folium sennae 50～100, stachyose 80～120.
3. the health food with bowel relaxing functions according to claim 1, is characterized in that: the weight portion proportioning of each active component is: radix scrophulariae 100, the Radix Astragali 100, the tuber of dwarf lilyturf 75, radish seed 75, folium sennae 75, stachyose 100.
4. according to the health food with bowel relaxing functions described in claim 1,2 or 3, it is characterized in that: the formulation of described health food is oral liquid, capsule, tablet, pulvis, beverage, mixture or granule.
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