CN102319342B - Medicament for relaxing bowel and preparation method thereof - Google Patents
Medicament for relaxing bowel and preparation method thereof Download PDFInfo
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Abstract
The invention provides a medicament for relaxing bowel and a preparation method thereof. The medicament is prepared from stir-fried radish seed, raw cinnamomvine, raw largehead atractylodes rhizome, white paeony root, desertliving cistanche, iridis tectori rhizome and honey. The medicament has an effect of relaxing bowel, offers a good mouthfeel, is convenient to take and easy to accept by patients, and has a good market prospect.
Description
Technical field
The present invention relates to medicine of a kind of loosening bowel to relieve constipation and preparation method thereof, belong to the technical field of medicine.
Technical background
Constipation is a kind of commonly encountered diseases and frequently-occurring disease, and the crowd at different ages has habitual constipation to occur, and wherein, constipation more easily occurs for old people and young people's comparison, and the constipation degree increases the weight of with the increase at age.The young and middle-aged constipation incidence rate of statistics is 1%～5%, and old people is 5%～30%, and the old people of long-term bed can be up to 80%.Although constipation is not a kind of disease, normal patient's the daily life of giving brings unhappiness and misery, even impact sleep and diet.If constipation is not treated for a long time, because every day, defecation frequency reduced, toxin should be absorbed, and jeopardizes the healthy of patient.Especially the old people is owing to constipation, and the firmly defecation that goes to toilet often causes the change of coronary artery and cerebral blood flow, because cerebral blood flow reduces, often easily faints; In addition, angina pectoris, myocardial infarction may occur in the coronary insufficiency person, and the hyperpietic can cause cerebrovascular accident, also can cause the breaking of aneurysm or ventricular aneurysm, mural thrombus of heart comes off, arrhythmia even die suddenly; Because the tunica muscularis coli hypotonia, Megacolon can occur, firmly Intra-abdominal pressure raises and can cause or increase the weight of hemorrhoid during defecation, by force damage anal canal during defecation, can cause other perianals such as anal fissure; Can produce intestinal obstruction, fecal ulcer, urine retention and fecal incontinence after the fecal impaction, also have colon spontaneous perforation or volvulus of sigmoid.Therefore, the treatment constipation is to preventing playing an important role of disease.
Summary of the invention
Medicine that provides a kind of loosening bowel to relieve constipation and preparation method thereof is provided technical problem to be solved by this invention, thereby overcomes above-mentioned the deficiencies in the prior art.
For solving above technical problem, the present invention is by the following technical solutions: a kind of medicine of loosening bowel to relieve constipation, calculate according to composition by weight, be prepared from by Semen Raphani (parched) 5-30 part, Rhizoma Dioscoreae 6-30 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Radix Paeoniae Alba 10-30 part, Herba Cistanches 10-40 part, Rhizoma Belamcandae 10-30 part and Mel 50-300 part.
Particularly, the medicine of described loosening bowel to relieve constipation calculates according to composition by weight, is prepared from by 175 parts of 15 parts of Semen Raphani (parched), 16 parts of Rhizoma Dioscoreae, 20 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of Radix Paeoniae Alba, 25 parts of Herba Cistanches, 20 parts of Rhizoma Belamcandaes and Mel.
The preparation method of the medicine of described loosening bowel to relieve constipation is: Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches, Rhizoma Belamcandae, Mel and conventional adjuvant are made conventional formulation according to conventional method.
Described preparation is oral liquid and honeyed pill.
Described oral liquid is mixture and oral liquid.
The preparation method of described oral liquid is: get first Mel and make refined honey, in addition Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches and Rhizoma Belamcandae are entered water soaking 10-50 minute that 6-15 doubly measures, decocted 0.5-3 hour, filter, add again the decocting that 6-15 doubly measures and boiled 0.5-3 hour, filter merge extractive liquid,, concentrated, mix with above-mentioned refined honey, add the sodium benzoate of amount of liquid medicine 0.15-0.25%, sterilization, packing, and get final product.
The preparation method of described honeyed pill is: get first Mel and make refined honey, in addition Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches and Rhizoma Belamcandae are ground into respectively fine powder, fine drug powder and above-mentioned refined honey are mixed and made into honeyed pill, and get final product.
Constipation is modal digestive system obstacle, and especially a lot of old peoples are subjected to its hardship deeply.The constipation majority is because patient's activity is few, and intestinal peristalsis promoting is slow, rectum muscle and upper abdomen atrophy, and hypotonia etc. cause defecation inability and cause constipation.In addition, bad living habit also can cause constipation.For example some patient lacks motion at ordinary times, and hypoposia is had a liking for food pungent, thereby forms constipation.The patient who also has does not have the regularly custom of defecation, unconsciously suppresses defecation, causes the defecation reflex sensation to reduce, and impulsion weakens, and feces overstays at large enteral, and moisture is absorbed and the exsiccation hardening, causes and excludes difficulty.Have, some patient takes some drugs because suffering from chronic diseases (hypertension, nephropathy, heart disease) again, such as diuretic, and the improper use of the medicines such as convulsion, anti-melancholy, resisting hypertension and cause body dehydration, enterokinesia is slow, thereby causes constipation.In addition, psychentonia, lather make whole body be subject to neural impact, and gastrointestinal function is suppressed, and also constipation can occur.
In the medicine of loosening bowel to relieve constipation of the present invention, Semen Raphani (parched) has the de-swelling of helping digestion, and the effect of lowering the adverse-rising QI to resolve phlegm is breathed with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots.Rhizoma Dioscoreae has the spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the effect of the kidney invigorating arresting seminal emission; Be used for insufficiency of the spleen lack of appetite, chronic diarrhea not less than, the deficiency of the lung breath with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat quench one's thirst.Rhizoma Atractylodis Macrocephalae is longer than the spleen invigorating relieving constipation.Radix Paeoniae Alba has enriches blood, yin fluid astringing easing the affected liver, the effect of relieving spasm to stop pain.Herba Cistanches has kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation; Mel can improve immunity, but prevent constipation also, above material combination, the effect of playing altogether loosening bowel to relieve constipation.
Compared with prior art, the medicine material reasonable recipe of loosening bowel to relieve constipation of the present invention, compatibility is precise and appropriate, meets TCM basis and medicine food with the theory of mending, and each raw material can both its unique effect of performance place, and mouthfeel is good, taking convenience, the patient is easy to accept.Has good market prospect.
For a better understanding of the present invention, the applicant has carried out pharmacological research to tea of the present invention.
1 materials and methods
1.1 test liquid preparation
According to the method for the invention medicine is made medicinal liquid, containing former medicine weight is 1200-3600mg/Kg.BM.d.
1.2 laboratory animal
SPF level Male Kunming strain mice, body weight is 18-22g, is provided by Guiyang Medical College.
1.3 experiment grouping
Be divided into 5 groups, 15 every group.Be respectively administration low dose group of the present invention (1200mg/kg.BW), dosage group (2400mg/kg.BW) in the administration of the present invention, administration high dose group of the present invention (3600mg/kg.BW), model control group and negative control group.
1.4 instrument and reagent operating scissors, ophthalmic tweezers, ruler, electronic balance, activated carbon powder, Radix Acaciae senegalis, R-1132 etc.
1.5 experimental technique
1.5.1 intestinal motility experiment
Each Experimental agents group is respectively administration according to dosage, and two matched groups give isopyknic distilled water, every day 1 time, successive administration 7 days.Each treated animal fasting in the evening on the same day of last administration (drinking-water is not limit), model control group and 3 dosage groups give the compound diphenoxylate solution (0.2ml/10g.BW) that dosage is 2mg/kg.BW after 16 hours, and negative control group gives distilled water.After 30 minutes, 3 dosage groups contain the prepared Chinese ink (containing 5% activated carbon powder, 10% Radix Acaciae senegalis) of medicine of the present invention, and model control group and negative control group give prepared Chinese ink.Give prepared Chinese ink cervical vertebra dislocation execution after 25 minutes, open the abdominal cavity and separate mesentery, clip upper end is the intestinal tube to ileocecus from pylorus, lower end, place on the pallet, gently small intestinal being pulled into straight line measures, Length of intestine is " small intestinal total length ", is " prepared Chinese ink propelling length " from pylorus to prepared Chinese ink forward position.Calculate prepared Chinese ink propelling rate by following formula, and carry out after the data conversion again statistical analysis.
Prepared Chinese ink propelling rate=prepared Chinese ink advances length/small intestinal total length * 100%;
1.5.2 the mensuration of defecation time, fecal grains and stool weight
Each administration group gives medicine of the present invention according to dosage respectively, every day 1 time, successive administration 7 days.Model control group and negative control group give isopyknic distilled water.Each treated animal fasting in the evening on the same day of last administration (drinking-water is not limit), model control group and 3 dosage groups give the compound diphenoxylate solution (0.2ml/10g.BW) that dosage is 10mg/kg.BW dosage after 16 hours, and negative control group gives the distilled water of equivalent.Give behind the compound diphenoxylate 30 minutes, model control group and negative control group mice give the prepared Chinese ink gavage, and 3 dosage groups contain the prepared Chinese ink of medicine of the present invention, begin simultaneously timing.Every animal is raised separately, and supplies with feedstuff and drinking-water, the time that every animal of observed and recorded is arranged melena first, defecation grain number and weight in 5 hours.
2 experimental results
2.1 medicine of the present invention is on the impact of the weight of animals
After giving medicine of the present invention, the diet of each treated animal and movable normal, the feces of dosage group mice are than the soft of matched group but loose stool do not occur.Body weight and negative control group and model control group comparison there was no significant difference when medicine group mice is finished in experiment, show medicine of the present invention on Mouse Weight without impact.See Table 1.
Table 1 is on the impact of body weight
Annotate: comparing difference there are no significant difference (P＞0.05) between each group in the table
2.2 medicine of the present invention is on the impact of mouse small intestine motion
The prepared Chinese ink propelling rate of Constipation Model control group mice significantly is lower than negative control group (P＜0.01), and the expression Constipation Model is set up.The prepared Chinese ink propelling rate of three dosage group mices is higher than model control group, and significant difference is arranged.See Table 2.
Table 2 is respectively organized the result of mouse small intestine ahead running
Annotate: compare with model group, * represents P＜0.05; * represents P＜0.01
2.3 medicine of the present invention is on the impact of mice defecation time, fecal grains and stool weight
Just and grain number and the stool weight of feces illustrates the Constipation Model establishment all less than negative control group (P＜0.01) to model control group head greater than negative control group (P＜0.01) time.Three dosage groups are compared with model control group, head just the time than model control group short (P＜0.05); Fecal grains is all greater than model control group (P＜0.05); Stool weight is also greater than model control group (P＜0.05); See Table 3.
Table 3 is respectively organized mice defecation time, fecal grains and stool weight result
Annotate: compare with model group, * represents P＜0.05; * represents P＜0.01
3 discuss
Experimental result demonstration, medicine of the present invention can obviously promote the mouse small intestine motion, increase fecal grains, stool weight and shorten first defecation time, show that medicine of the present invention has the effect of relieving constipation.
The specific embodiment
Embodiment 1:
Prescription: Semen Raphani (parched) 15g, Rhizoma Dioscoreae 16g, Rhizoma Atractylodis Macrocephalae 20g, Radix Paeoniae Alba 20g, Herba Cistanches 25g, Rhizoma Belamcandae 20g, Mel 175g.
Preparation technology: get first Mel and make refined honey, in addition Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches and Rhizoma Belamcandae are ground into respectively fine powder, first with the fine drug powder mixing, be mixed and made into honeyed pill with above-mentioned refined honey again, every ball 9g, and get final product.
Usage and dosage: oral, every day three times, each one.
Embodiment 2:
Prescription: Semen Raphani (parched) 30g, Rhizoma Dioscoreae 30g, Rhizoma Atractylodis Macrocephalae 30g, Radix Paeoniae Alba 30g, Herba Cistanches 40g, Rhizoma Belamcandae 30g, Mel 300g.
Preparation technology: get first Mel and make refined honey, in addition Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches and Rhizoma Belamcandae are ground into respectively fine powder, first with the fine drug powder mixing, be mixed and made into honeyed pill with above-mentioned refined honey again, every ball 9g, and get final product.
Usage and dosage: oral, every day three times, each one.
Embodiment 3:
Prescription: Semen Raphani (parched) 5g, Rhizoma Dioscoreae 6g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 10g, Herba Cistanches 10g, Rhizoma Belamcandae 10g, Mel 50g.
Preparation technology: get first Mel and make refined honey, in addition Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches and Rhizoma Belamcandae are entered the water soaking 10 minutes of 15 times of amounts, decocted 3 hours, filter, the decocting that adds again 15 times of amounts boiled 3 hours, filtered merge extractive liquid,, be concentrated into 600ml, mix with above-mentioned refined honey, add the sodium benzoate of amount of liquid medicine 0.25%, sterilization, packing namely gets oral liquid.
Usage and dosage: oral, every day three times, each 15ml.
Embodiment 4:
Prescription: Semen Raphani (parched) 30g, Rhizoma Dioscoreae 30g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 10g, Herba Cistanches 10g, Rhizoma Belamcandae 30g, Mel 180g.
Preparation technology: get first Mel and make refined honey, in addition Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches and Rhizoma Belamcandae are ground into respectively fine powder, first with the fine drug powder mixing, be mixed and made into honeyed pill with above-mentioned refined honey again, every ball 9g, and get final product.
Usage and dosage: oral, every day three times, each one.
Embodiment 5:
Prescription: Semen Raphani (parched) 5g, Rhizoma Dioscoreae 6g, Rhizoma Atractylodis Macrocephalae 30g, Radix Paeoniae Alba 30g, Herba Cistanches 40g, Rhizoma Belamcandae 10g, Mel 300g.
Preparation technology: get first Mel and make refined honey, in addition Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches and Rhizoma Belamcandae are entered the water soaking 50 minutes of 6 times of amounts, decocted 0.5 hour, filter, the decocting that adds again 6 times of amounts boiled 0.5 hour, filtered merge extractive liquid,, be concentrated into 9000ml, mix with above-mentioned refined honey, add the sodium benzoate of amount of liquid medicine 0.15%, sterilization, packing namely gets mixture.
Usage and dosage: early, late (medicine) being taken before meal usefulness, each oral 150ml.
Claims (6)
1. the medicine of a loosening bowel to relieve constipation is characterized in that: calculate according to composition by weight, be prepared from by 175 parts of 15 parts of Semen Raphani (parched), 16 parts of Rhizoma Dioscoreae, 20 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of Radix Paeoniae Alba, 25 parts of Herba Cistanches, 20 parts of Rhizoma Belamcandaes and Mel.
2. prepare the as claimed in claim 1 method of the medicine of loosening bowel to relieve constipation, it is characterized in that: Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches, Rhizoma Belamcandae, Mel and conventional adjuvant are made conventional formulation according to conventional method.
3. prepare as claimed in claim 2 the method for the medicine of loosening bowel to relieve constipation, it is characterized in that: described preparation is oral liquid or honeyed pill.
4. prepare as claimed in claim 3 the method for the medicine of loosening bowel to relieve constipation, it is characterized in that: described oral liquid is mixture or oral liquid.
5. the method for preparing as claimed in claim 3 the medicine of loosening bowel to relieve constipation, it is characterized in that: the preparation method of described oral liquid is: get first Mel and make refined honey, in addition Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches and Rhizoma Belamcandae are entered water soaking 10-50 minute that 6-15 doubly measures, decocted 0.5-3 hour, filter, adding the decocting that 6-15 doubly measures boiled 0.5-3 hour again, filter, merge extractive liquid,, concentrated, mix with above-mentioned refined honey, the sodium benzoate that adds amount of liquid medicine 0.15-0.25%, sterilization, packing, and get final product.
6. the method for preparing as claimed in claim 3 the medicine of loosening bowel to relieve constipation, it is characterized in that: the preparation method of described honeyed pill is: get first Mel and make refined honey, in addition Semen Raphani (parched), Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Herba Cistanches and Rhizoma Belamcandae are ground into respectively fine powder, fine drug powder and above-mentioned refined honey are mixed and made into honeyed pill, and get final product.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813913A (en) * | 2012-09-12 | 2012-12-12 | 贵州神奇药业股份有限公司 | Sichuan blackberry extract composition |
| CN102813911A (en) * | 2012-09-12 | 2012-12-12 | 贵州神奇药业股份有限公司 | Medicine used for treating constipation |
| CN107375697B (en) * | 2017-08-30 | 2021-06-29 | 厦门元之道生物科技有限公司 | Compound preparation with bowel relaxing function and preparation method and application thereof |
| CN109125565A (en) * | 2018-09-28 | 2019-01-04 | 福建省中科生物股份有限公司 | A kind of composition with function of relaxing bowel |
| CN110507773B (en) * | 2019-09-26 | 2021-04-13 | 上海市静安区中医医院 | Traditional Chinese medicine composition for treating constipation of Parkinson's disease and application thereof |
| CN113115936A (en) * | 2021-04-28 | 2021-07-16 | 成都肛肠专科医院 | Traditional Chinese medicine medicated diet for healing wound after hemorrhoid operation and preparation method thereof |
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| CN101940621A (en) * | 2010-05-28 | 2011-01-12 | 中国人民解放军总医院 | Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof |
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| CN101940621A (en) * | 2010-05-28 | 2011-01-12 | 中国人民解放军总医院 | Chinese medicinal composition and preparation for relaxing bowel and preparation method thereof |
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