CN109125565A - A kind of composition with function of relaxing bowel - Google Patents
A kind of composition with function of relaxing bowel Download PDFInfo
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- CN109125565A CN109125565A CN201811136613.2A CN201811136613A CN109125565A CN 109125565 A CN109125565 A CN 109125565A CN 201811136613 A CN201811136613 A CN 201811136613A CN 109125565 A CN109125565 A CN 109125565A
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- lettuce
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- 239000000203 mixture Substances 0.000 title claims abstract description 287
- 230000002040 relaxant effect Effects 0.000 title abstract description 6
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- 241000208822 Lactuca Species 0.000 claims abstract description 71
- 235000003228 Lactuca sativa Nutrition 0.000 claims abstract description 71
- 239000002994 raw material Substances 0.000 claims abstract description 63
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 56
- 235000002961 Aloe barbadensis Nutrition 0.000 claims abstract description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 105
- 239000000725 suspension Substances 0.000 claims description 94
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- 235000000318 Bindesalat Nutrition 0.000 claims description 87
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims description 67
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- 244000144927 Aloe barbadensis Species 0.000 claims description 53
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- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 45
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- 238000002360 preparation method Methods 0.000 claims description 15
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- HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 description 41
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- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 6
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- 238000000926 separation method Methods 0.000 description 3
- 241001116389 Aloe Species 0.000 description 2
- YDQWDHRMZQUTBA-UHFFFAOYSA-N Aloe emodin Chemical compound C1=CC=C2C(=O)C3=CC(CO)=CC(O)=C3C(=O)C2=C1O YDQWDHRMZQUTBA-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 208000007976 Ketosis Diseases 0.000 description 2
- FLDFNEBHEXLZRX-DLQNOBSRSA-N Nystose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(O[C@@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 FLDFNEBHEXLZRX-DLQNOBSRSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
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- 238000005516 engineering process Methods 0.000 description 2
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- -1 trisaccharide oligosaccharides Chemical class 0.000 description 2
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- CPUHNROBVJNNPW-UHFFFAOYSA-N aloin A Natural products OC1C(O)C(O)C(CO)OC1OC1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 CPUHNROBVJNNPW-UHFFFAOYSA-N 0.000 description 1
- AFHJQYHRLPMKHU-WEZNYRQKSA-N aloin B Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-WEZNYRQKSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 1
- 229940107187 fructooligosaccharide Drugs 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
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- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
Abstract
The invention belongs to the technical fields of health care, and in particular to a kind of composition with function of relaxing bowel.Composition of the invention, preparing raw material includes: graceful lettuce juice, green butterfly lettuce juice, aloe barbadensis Miller juice, oligofructose.The present invention plays each component advantage by combination, generates synergistic effect, improve the Emptying Rate of human stomach, promotes enterogastric peristalsis, can reach the effect for alleviating constipation.The composition using have discharge function medicinal material, not only can to avoid adverse reactions such as Nausea and vomiting, metabolic disturbance of electrolyte, but also without deactivate after restore constipation phenomenon it is lighter, be especially suitable for children, old man and weakness of the spleen and the stomach people constipation.Meanwhile beverage or oral solution rear housecoat use is made, it is easy to carry about with one.It is 2-3 times daily, consumer's organism metabolism function can be improved.
Description
Technical field
The invention belongs to the technical fields of health care, and in particular to a kind of composition with function of relaxing bowel.
Background technique
Constipation is clinical common complicated symptom, rather than a kind of disease, is primarily referred to as defecation frequency reduction, excrement amount subtracts
Less, excrement is dry and hard, defecation is laborious etc..Must in conjunction with excrement character, I usually whether there is or not difficulties to make for bowl evacuation habit and defecation
Whether there is or not the judgements of constipation.It was such as chronic constipation more than 6 months.
In the market for constipation, Western medicine mainly uses stimulable type or displacement type pharmacological action, stimulates enterocinesia or increase
Enteral moisture, softer stool carry out compound combination to reach therapeutic effect, or using the Chinese medicine of relax bowel and defecation in Chinese medicine
To use.For a long time, the therapeutic modality for largely using Western medicine and Chinese medicine will cause the decline of human consumption's function, therefore often be discontinued
After recur.
Summary of the invention
In view of the problems of in the prior art, the purpose of the present invention is to provide a kind of with function of relaxing bowel
Composition.In composition of the invention, containing graceful lettuce juice, green butterfly lettuce juice, in the gracefulness lettuce juice, green butterfly lettuce juice
Containing dietary fiber, plays the role of absorbing moisture content in digestive system by dietary fiber, increase the food body in enteron aisle and stomach
Product increases Emptying Rate, can promote enterogastric peristalsis, can reach the effect for alleviating constipation.
To achieve the goals above and other related purposes, the invention adopts the following technical scheme:
The first aspect of the present invention provides a kind of composition, and preparing raw material includes: graceful lettuce juice, green butterfly romaine lettuce
Juice, aloe barbadensis Miller juice, oligofructose.
In the present invention, graceful lettuce juice obtains after directly being squeezed the juice by graceful romaine lettuce.
In the present invention, the gracefulness romaine lettuce is commercialized romaine lettuce cultivar.Mainly use plant factor's water planting
Mode planted, crushing juice rate is high.It can be obtained by commercially available approach.For example, can Japan buy graceful romaine lettuce seed or
The graceful romaine lettuce that person has planted.
In the present invention, green butterfly lettuce juice obtains after directly being squeezed the juice by green butterfly romaine lettuce.
In the present invention, the green butterfly romaine lettuce is commercialized romaine lettuce cultivar.Mainly use plant factor's water planting
Mode planted, crushing juice rate is high.It can be obtained by commercially available approach.For example, can Japan buy green butterfly romaine lettuce seed or
The green butterfly romaine lettuce that person has planted.
In the present invention, aloe barbadensis Miller juice obtains after directly being squeezed the juice by aloe barbadensis Miller.
In the present invention, the aloe barbadensis Miller is the perennial evergreen succulent plant of A Fu flower section's Aloe, is originated in non-
Continent.The Classification system of the aloe barbadensis Miller is Aloe vera L..
In the present invention, the oligofructose, abbreviation FOS, also known as Fructooligosaccharides, cane fruit trisaccharide oligosaccharides or sugarcane fruit are oligomeric
Sugar, refer on the residue of fructose of sucrose molecule by ketose made of 1~3 fructosyl of β (1-2) glucosides key connection,
Nystose, sugarcane sugar, six sugar of sugarcane fruit and its mixture.The molecular formula of the oligofructose: GFn, polymerization degree n=2~5.
The oligofructose is the p-type oligofructose of oligofructose content >=90%.According to China's light industry professional standard
The regulation of QB2583-2003 " oligofructose ": it is divided into G type and p-type, oligofructose total content >=50% by oligofructose total content
Person is G type；Oligofructose content >=90% are p-type.
The molecular weight of the oligofructose is 100~300 dalton.
In the present composition, graceful lettuce juice, green butterfly lettuce juice, aloe barbadensis Miller juice, oligofructose is selected to carry out group
It closes, graceful romaine lettuce, green butterfly romaine lettuce contain a large amount of dietary fiber and various trace elements, graceful, the green butterfly of plant factor's water planting
Without containing heavy metal and pesticide remnant, therefore gastrointestinal tract mucosa and hepatic and renal function will not be caused empty stomach is edible to damage and bear
Load.The effective components such as aloin, aloe-emodin in aloe barbadensis Miller play improve a poor appetite, large intestine delay the effect of letting out.
Appropriate aloe barbadensis Miller is taken, stomach function can be strengthened, built up health, the patient that is critically ill of appetite is lost because of real example cause void, is taken
Aloe barbadensis Miller can also restore appetite.In the present composition, oligofructose is also known as fructooligosaccharide, is a kind of aqueous soluble dietary
Fiber, long-term use can reduce serum cholesterol, improve lipid-metabolism.Oligofructose is generated in big enteral by bacterial fermentation
Pfansteihl can promote absorption of the human body to minerals with minerals such as dissolving calcium, magnesium, iron.It is excellent that each component is played by combination
Gesture generates synergistic effect, improves the Emptying Rate of human stomach, promotes enterogastric peristalsis, can reach the effect for alleviating constipation.It should
Composition, not only can be bad anti-to avoid Nausea and vomiting, metabolic disturbance of electrolyte etc. not using having discharge function medicinal material
It answers, and lighter without recovery constipation phenomenon after deactivating, is especially suitable for the constipation of children, old man and weakness of the spleen and the stomach people.Meanwhile
Beverage is made or oral solution rear housecoat is used, is easy to carry about with one.It is 2-3 times daily, consumer's organism metabolism function can be improved.
In a kind of embodiment, the weight part ratio range respectively prepared between raw material is: graceful lettuce juice 1-3 weight
Part, green butterfly lettuce juice 1-3 parts by weight, aloe barbadensis Miller juice 1-3 parts by weight, oligofructose 1-20 parts by weight.
In a kind of embodiment, the weight part ratio range respectively prepared between raw material is: graceful lettuce juice 2-3 weight
Part, green butterfly lettuce juice 1-3 parts by weight, aloe barbadensis Miller juice 1-3 parts by weight, oligofructose 5-20 parts by weight.
In a kind of embodiment, the weight part ratio range respectively prepared between raw material is: graceful lettuce juice 1-2 weight
Part, green 1 parts by weight of butterfly lettuce juice, 1 parts by weight of aloe barbadensis Miller juice, oligofructose 1-5 parts by weight.
In a kind of embodiment, the weight part ratio range respectively prepared between raw material is: graceful 1 parts by weight of lettuce juice,
Green 1 parts by weight of butterfly lettuce juice, 1 parts by weight of aloe barbadensis Miller juice, 1 parts by weight of oligofructose.
In a kind of embodiment, the weight part ratio respectively prepared between raw material is: graceful 3 parts by weight of lettuce juice, green butterfly
3 parts by weight of lettuce juice, 3 parts by weight of aloe barbadensis Miller juice, 20 parts by weight of oligofructose.
In a kind of embodiment, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of lettuce juice, green butterfly
1 parts by weight of lettuce juice, 1 parts by weight of aloe barbadensis Miller juice, 5 parts by weight of oligofructose.
It further include probiotics in the composition in a kind of embodiment.
In a kind of embodiment, the probiotics is selected from bifidobacterium lactis, lactobacillus acidophilus.
In a kind of embodiment, the raw material for preparing of the composition further includes bifidobacterium lactis suspension and/or acidophilus cream bar
Bacteria suspension.
The bifidobacterium lactis suspension is acquisition that bifidobacterium lactis powder is dissolved in the water.In a kind of embodiment, every 1 weight
It measures and contains 1g water and 2000*10 in the bifidobacterium lactis suspension of part8Cfu bifidobacterium lactis.
The lactobacillus acidophilus suspension is acquisition that lactobacillus acidophilus powder is dissolved in the water.In a kind of embodiment, every 1 weight
It measures and contains 1g water and 1500*10 in the lactobacillus acidophilus suspension of part8Cfu lactobacillus acidophilus.
In a kind of embodiment, the raw material for preparing of the composition further includes bifidobacterium lactis suspension 1-5 parts by weight.
In a kind of embodiment, the raw material for preparing of the composition further includes bifidobacterium lactis suspension 1-3.3 parts by weight.
In a kind of embodiment, the raw material for preparing of the composition further includes bifidobacterium lactis suspension 3.3-5 parts by weight.
In a kind of embodiment, the raw material for preparing of the composition further includes 1 parts by weight of bifidobacterium lactis suspension.
In a kind of embodiment, the raw material for preparing of the composition further includes 3.3 parts by weight of bifidobacterium lactis suspension.
In a kind of embodiment, the raw material for preparing of the composition further includes 5 parts by weight of bifidobacterium lactis suspension.
In a kind of embodiment, the raw material for preparing of the composition further includes lactobacillus acidophilus suspension 1-5 parts by weight.
In a kind of embodiment, the raw material for preparing of the composition further includes lactobacillus acidophilus suspension 1-3.3 parts by weight.
In a kind of embodiment, the raw material for preparing of the composition further includes lactobacillus acidophilus suspension 3.3-5 parts by weight.
In a kind of embodiment, the raw material for preparing of the composition further includes 1 parts by weight of lactobacillus acidophilus suspension.
In a kind of embodiment, the raw material for preparing of the composition further includes 3.3 parts by weight of lactobacillus acidophilus suspension.
In a kind of embodiment, the raw material for preparing of the composition further includes 5 parts by weight of lactobacillus acidophilus suspension.
In a kind of embodiment, the composition prepare raw material further include bifidobacterium lactis suspension 0.5-2 parts by weight, it is thermophilic
Lactobacillus lactis suspension 0.5-2 parts by weight.
In a kind of embodiment, the composition prepare raw material further include bifidobacterium lactis suspension 0.5-2 parts by weight, it is thermophilic
Lactobacillus lactis suspension 0.5-1 parts by weight.
In a kind of embodiment, the composition prepare raw material further include bifidobacterium lactis suspension 0.5-2 parts by weight, it is thermophilic
Lactobacillus lactis suspension 1-2 parts by weight.
In a kind of embodiment, the composition prepare raw material further include bifidobacterium lactis suspension 0.5-2 parts by weight, it is thermophilic
0.5 parts by weight of Lactobacillus lactis suspension.
In a kind of embodiment, the composition prepare raw material further include bifidobacterium lactis suspension 0.5-2 parts by weight, it is thermophilic
1 parts by weight of Lactobacillus lactis suspension.
In a kind of embodiment, the composition prepare raw material further include bifidobacterium lactis suspension 0.5-2 parts by weight, it is thermophilic
2 parts by weight of Lactobacillus lactis suspension.
In a kind of embodiment, the composition prepare raw material further include bifidobacterium lactis suspension 0.5-1 parts by weight, it is thermophilic
Lactobacillus lactis suspension 0.5-2 parts by weight.
In a kind of embodiment, the raw material for preparing of the composition further includes bifidobacterium lactis suspension 1-2 parts by weight, acidophilus
Lactobacillus suspension 0.5-2 parts by weight.
In a kind of embodiment, the raw material for preparing of the composition further includes 0.5 parts by weight of bifidobacterium lactis suspension, acidophilus
Lactobacillus suspension 0.5-2 parts by weight.
In a kind of embodiment, the raw material for preparing of the composition further includes 1 parts by weight of bifidobacterium lactis suspension, acidophilus cream
Bacillus suspension 0.5-2 parts by weight.
In a kind of embodiment, the raw material for preparing of the composition further includes 0.5 parts by weight of bifidobacterium lactis suspension, acidophilus
0.5 parts by weight of lactobacillus suspension.
In a kind of embodiment, the raw material for preparing of the composition further includes 1 parts by weight of bifidobacterium lactis suspension, acidophilus cream
1 parts by weight of bacillus suspension.
In a kind of embodiment, the raw material for preparing of the composition further includes 2 parts by weight of bifidobacterium lactis suspension, acidophilus cream
2 parts by weight of bacillus suspension.
In a kind of embodiment, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly are raw
1 parts by weight of dish, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 1 parts by weight of bifidobacterium lactis suspension.
In a kind of embodiment, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly are raw
1 parts by weight of dish, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 3.3 parts by weight of bifidobacterium lactis suspension.
In a kind of embodiment, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly are raw
1 parts by weight of dish, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 5 parts by weight of bifidobacterium lactis suspension.
In a kind of embodiment, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly are raw
1 parts by weight of dish, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 1 parts by weight of lactobacillus acidophilus suspension.
It is graceful 2 parts by weight of romaine lettuce, green 1 parts by weight of butterfly romaine lettuce, 1 parts by weight of aloe barbadensis Miller, oligomeric in a kind of embodiment
5 parts by weight of fructose, 3.3 parts by weight of lactobacillus acidophilus suspension.
In a kind of embodiment, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly are raw
1 parts by weight of dish, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 5 parts by weight of lactobacillus acidophilus suspension.
In a kind of embodiment, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly are raw
1 parts by weight of dish, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 0.5 parts by weight of bifidobacterium lactis suspension, acidophilus cream bar
0.5 parts by weight of bacteria suspension.
In a kind of embodiment, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly are raw
1 parts by weight of dish, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 1 parts by weight of bifidobacterium lactis suspension, lactobacillus acidophilus
1 parts by weight of suspension.
It is graceful 2 parts by weight of romaine lettuce, green 1 parts by weight of butterfly romaine lettuce, 1 parts by weight of aloe barbadensis Miller, oligomeric in a kind of embodiment
5 parts by weight of fructose, 2 parts by weight of bifidobacterium lactis suspension, 2 parts by weight of lactobacillus acidophilus suspension.
In a kind of embodiment, the weight part ratio respectively prepared between raw material is: graceful 10 parts by weight of romaine lettuce, green butterfly are raw
5 parts by weight of dish, 5 parts by weight of aloe barbadensis Miller, 25 parts by weight of oligofructose, 16.5 parts by weight of bifidobacterium lactis suspension.
In a kind of embodiment, composition is diluted using pure water.
In a kind of embodiment, composition is diluted using pure water.
In a kind of embodiment, 4-30 parts by weight of purified water is respectively adopted in composition, composition is diluted.
In a kind of embodiment, 4-24 parts by weight of purified water is respectively adopted in composition, composition is diluted.
In a kind of embodiment, 4-20 parts by weight of purified water is respectively adopted in composition, composition is diluted.
In a kind of embodiment, 4-10 parts by weight of purified water is respectively adopted in composition, composition is diluted.
In a kind of embodiment, 10-30 parts by weight of purified water is respectively adopted in composition, composition is diluted.
In a kind of embodiment, 10-24 parts by weight of purified water is respectively adopted in composition, composition is diluted.
In a kind of embodiment, 10-20 parts by weight of purified water is respectively adopted in composition, composition is diluted.
In a kind of embodiment, 20-30 parts by weight of purified water is respectively adopted in composition, composition is diluted.
In a kind of embodiment, 20-24 parts by weight of purified water is respectively adopted in composition, composition is diluted.
In a kind of embodiment, it is pure that 4 parts by weight pure water, 10 parts by weight of purified water, 20 parts by weight are respectively adopted in composition
Water, 24 parts by weight of purified water or 30 parts by weight of purified water are diluted composition.
The second aspect of the present invention provides the preparation method of aforementioned composition, comprising steps of
Each raw material for preparing is uniformly mixed to get composition.
The third aspect of the present invention provides the purposes that aforementioned composition is used to prepare relax bowel and defecation product.
Affiliated product can be drug, can be health care product, can be the product of food or other forms.
Compared with prior art, the invention has the following beneficial effects:
The present invention plays each component advantage by combination, generates synergistic effect, improve the Emptying Rate of human stomach,
Promote enterogastric peristalsis, can reach the effect for alleviating constipation.The composition using having discharge function medicinal material, can not only not kept away
Exempt from the adverse reactions such as Nausea and vomiting, metabolic disturbance of electrolyte, and lighter without restoring constipation phenomenon after deactivating, is especially suitable for
The constipation of children, old man and weakness of the spleen and the stomach people.Meanwhile beverage or oral solution rear housecoat use is made, it is easy to carry about with one.Daily 2-
3 times, consumer's organism metabolism function can be improved.
Detailed description of the invention
Fig. 1: the effect picture that each single-item influences the weight of mouse.
Fig. 2: effect picture of each single-item to mouse small intestine ink progradation.
Fig. 3: effect picture of each single-item to small mouse's head just time effects.
Fig. 4: the effect picture that each single-item influences excrement water content in mouse 5 hours.
Fig. 5: effect picture of each composition to mouse small intestine ink progradation in embodiment 4.
Fig. 6: the effect picture that each composition influences excrement water content in mouse 5 hours in embodiment 4.
Fig. 7: effect picture of each composition to mouse small intestine ink progradation in embodiment 6.
Fig. 8: the effect picture that each composition influences excrement water content in mouse 5 hours in embodiment 7.
Fig. 9: in embodiment 8, the tap water and pure water diluted composition of different proportion are to mouse small intestine ink progradation
Effect picture.
Specific embodiment
Before further describing the specific embodiments of the present invention, it should be appreciated that protection scope of the present invention is not limited to down
State specific specific embodiment；It is also understood that term used in the embodiment of the present invention is specific specific in order to describe
Embodiment, rather than limiting the scope of protection of the present invention.
When embodiment provides numberical range, it should be appreciated that except non-present invention is otherwise noted, two ends of each numberical range
Any one numerical value can be selected between point and two endpoints.Unless otherwise defined, the present invention used in all technologies and
Scientific term is identical as the normally understood meaning of those skilled in the art of the present technique.Except specific method, equipment used in embodiment,
Outside material, grasp and record of the invention according to those skilled in the art to the prior art can also be used and this
Any method, equipment and the material of the similar or equivalent prior art of method described in inventive embodiments, equipment, material come real
The existing present invention.
Embodiment 1
Formulation optimization screening is carried out with iceberg romaine lettuce, graceful romaine lettuce, green butterfly romaine lettuce, Boston romaine lettuce.
In the present invention, the iceberg romaine lettuce, bile ingredients are commonly called as iceberg romaine lettuce, western romaine lettuce, are a kind of lettuce class of prevalence
Type.
The gracefulness romaine lettuce is commercialized romaine lettuce cultivar.Mainly carried out by the way of plant factor's water planting
Plantation, can be obtained by commercially available approach.For example, the gracefulness that can be bought the seed of graceful romaine lettuce in Japan or plant is raw
Dish.
The green butterfly romaine lettuce is commercialized romaine lettuce cultivar.Mainly carried out by the way of plant factor's water planting
Plantation.It can be obtained by commercially available approach.For example, can be raw in the green butterfly that Japan buys the seed of green butterfly romaine lettuce or has planted
Dish.
In the present invention, Boston romaine lettuce, also known as cream romaine lettuce are one of romaine lettuce kind, can be by commercially available
Approach obtains.
Mouse is divided into five groups, every group 10, is denoted as romaine lettuce group, graceful group, green butterfly group, Boston group and distilled water respectively
Group.
Wherein, romaine lettuce group: with lettuce juice, (other any ingredients are not added, also without any in acquisition of directly being squeezed the juice by romaine lettuce
Dilution) feeding mouse, once a day, and each 3g, continuous feeding one week.
Graceful group: it (is directly squeezed the juice acquisition by graceful romaine lettuce) feeding mouse with graceful lettuce juice, once a day, each 3g,
Continuous feeding one week.
Green butterfly group: (directly being squeezed the juice acquisition) feeding mouse with green butterfly lettuce juice by green butterfly romaine lettuce, once a day, each 3g,
Continuous feeding one week.
Boston group: it (is directly squeezed the juice acquisition by Boston romaine lettuce) feeding mouse with Boston lettuce juice, once a day, often
Secondary 3g, continuous feeding one week.
Distilled water group: using distilled water feeding mouse, once a day, each 5ml, continuous feeding one week, as control.
The excrement of each group mouse is softer than control group but does not occur loose stools.
As shown in Figure 1, there was no significant difference compared with the control group for weight at the end of experiment for single-item group mouse, show this reality
Each single-item is applied in example on mouse weight without influence, illustrates above-mentioned single-item to mouse without obvious toxic-side effects.
Embodiment 2
According to the method in embodiment 1, mouse is divided into five groups, every group 10, is denoted as romaine lettuce group, graceful group, green respectively
Butterfly group, Boston group and distilled water group.
Wherein, romaine lettuce group, with lettuce juice, (other any ingredients are not added, also without any in acquisition of directly being squeezed the juice by romaine lettuce
Dilution) feeding mouse, once a day, and each 3g, continuous feeding one week.The mouse of feeding after a week, gives diphenoxylate respectively
Solution (dosage 0.2ml/10g), three give again ten minutes later containing lettuce juice prepared Chinese ink (containing 5% active powdered carbon,
10% gum arabic, surplus are lettuce juice), cervical dislocation is put to death after giving prepared Chinese ink 25 minutes, is opened abdominal cavity and is separated intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%), and statisticallyd analyze again after carrying out data conversion.
Graceful group: with graceful lettuce juice (by graceful romaine lettuce directly squeeze the juice acquisition, be not added other any ingredients, also without
Any dilution) feeding mouse, once a day, and each 3g, continuous feeding one week.It is fragrant to give ground respectively for the mouse of feeding after a week
Promise ester solution (dosage 0.2ml/10g), three give the prepared Chinese ink containing graceful lettuce juice (containing 5% work again ten minutes later
Property powdered carbon, 10% gum arabic, surplus be graceful lettuce juice), cervical dislocation is put to death after giving prepared Chinese ink 25 minutes, is opened
Abdominal cavity separates mesenterium, and clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently pulls into small intestine directly
Line measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".By following equation
Ink progradation (ink progradation=prepared Chinese ink promote length/total small intestinal length × 100%) is calculated, and is carried out after data conversion again
Statistical analysis.
Green butterfly group: with green butterfly lettuce juice (by green butterfly romaine lettuce directly squeeze the juice acquisition, be not added other any ingredients, also without
Any dilution) feeding mouse, once a day, and each 3g, continuous feeding one week.It is fragrant to give ground respectively for the mouse of feeding after a week
Promise ester solution (dosage 0.2ml/10g), three give the prepared Chinese ink containing green butterfly lettuce juice (containing 5% work again ten minutes later
Property powdered carbon, 10% gum arabic, surplus be green butterfly lettuce juice), after giving prepared Chinese ink 25 minutes cervical dislocation put to death, open
Abdominal cavity separates mesenterium, and clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently pulls into small intestine directly
Line measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".By following equation
Ink progradation (ink progradation=prepared Chinese ink promote length/total small intestinal length × 100%) is calculated, and is carried out after data conversion again
Statistical analysis.
Boston group: with Boston lettuce juice (by Boston romaine lettuce directly squeeze the juice acquisition, be not added other any ingredients,
Without any dilution) feeding mouse, once a day, and each 3g, continuous feeding one week.The mouse of feeding after a week, gives respectively
Diphenoxylate solution (dosage 0.2ml/10g) is given, three give the prepared Chinese ink containing Boston lettuce juice again ten minutes later (contains
5% active powdered carbon, 10% gum arabic, surplus are Boston lettuce juice), give cervical dislocation after prepared Chinese ink 25 minutes
It puts to death, opens abdominal cavity and separate mesenterium, clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently will be small
Intestines pull into straight line and measure, and Length of intestine is " total small intestinal length ", are from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".It presses
Following equation calculates ink progradation (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%), and carries out data
It is statisticallyd analyze again after conversion.
Distilled water group: using distilled water feeding mouse, once a day, each 5ml, continuous feeding one week, as control.Feeding
Mouse after a week gives diphenoxylate solution (dosage 0.2ml/10g) respectively, and three give again ten minutes later containing steaming
The prepared Chinese ink (active powdered carbon, 10% gum arabic, surplus containing 5% are distilled water) of distilled water, after giving prepared Chinese ink 25 minutes
Cervical dislocation is put to death, and is opened abdominal cavity and is separated mesenterium, and clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus,
Small intestine is gently pulled into straight line to measure, Length of intestine is " total small intestinal length ", from pylorus to prepared Chinese ink forward position for " prepared Chinese ink promotes
Length ".It is calculated according to the following formula ink progradation (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%), and
It is statisticallyd analyze again after carrying out data conversion.
As a result as shown in Fig. 2, compared with the control group, graceful group, green butterfly group all have significant difference, show graceful life
Dish, green butterfly romaine lettuce have the function of enteron aisle to lubricate defaecation.
Embodiment 3
According to the method in embodiment 1, mouse is divided into five groups, every group 10, is denoted as romaine lettuce group, graceful group, green respectively
Butterfly group, Boston group and distilled water group.
Wherein, romaine lettuce group, with lettuce juice, (other any ingredients are not added, also without any in acquisition of directly being squeezed the juice by romaine lettuce
Dilution) feeding mouse, once a day, and each 3g, continuous feeding one week.The mouse of feeding after a week, gives diphenoxylate respectively
Solution (dosage 0.2ml/10g), three give the prepared Chinese ink stomach-filling containing lettuce juice again ten minutes later, start simultaneously at timing.
Every animal is individually raised, and supplies feed and drinking-water, observes and records the time that every animal arranges melena for the first time, in five hours
Defecation weight and water content.
Graceful group: with graceful lettuce juice (by graceful romaine lettuce directly squeeze the juice acquisition, be not added other any ingredients, also without
Any dilution) feeding mouse, once a day, and each 3g, continuous feeding one week.It is fragrant to give ground respectively for the mouse of feeding after a week
Promise ester solution (dosage 0.2ml/10g), three give the prepared Chinese ink stomach-filling containing graceful lettuce juice again ten minutes later, open simultaneously
Beginning timing.Every animal is individually raised, and supplies feed and drinking-water, observes and records the time that every animal arranges melena for the first time, and five
Defecation weight and water content in hour.
Green butterfly group: with green butterfly lettuce juice (by green butterfly romaine lettuce directly squeeze the juice acquisition, be not added other any ingredients, also without
Any dilution) feeding mouse, once a day, and each 3g, continuous feeding one week.It is fragrant to give ground respectively for the mouse of feeding after a week
Promise ester solution (dosage 0.2ml/10g), three give the prepared Chinese ink stomach-filling containing green butterfly lettuce juice again ten minutes later, open simultaneously
Beginning timing.Every animal is individually raised, and supplies feed and drinking-water, observes and records the time that every animal arranges melena for the first time, and five
Defecation weight and water content in hour.
Boston group: with Boston lettuce juice (by Boston romaine lettuce directly squeeze the juice acquisition, be not added other any ingredients,
Without any dilution) feeding mouse, once a day, and each 3g, continuous feeding one week.The mouse of feeding after a week, gives respectively
Diphenoxylate solution (dosage 0.2ml/10g) is given, three give the prepared Chinese ink containing Boston lettuce juice again ten minutes later fills
Stomach starts simultaneously at timing.Every animal is individually raised, and supplies feed and drinking-water, observes and records every animal and arranges melena for the first time
Time, defecation weight and water content in five hours.
Distilled water group: using distilled water feeding mouse, once a day, each 5ml, continuous feeding one week, as control.
We as can see from Figure 3 graceful group, just there is significant difference in the time to the green small mouse's head of butterfly group compared with the control group；
Graceful group, the water content in green butterfly group stool in mice have significantly compared with the control group as can see from Figure 4 for we
Sex differernce equally illustrates that graceful and green butterfly facilitates the effect of ease constipation and defecation.
Embodiment 4
It investigates possessed by graceful lettuce juice, green butterfly lettuce juice carry out respectively with other components after the composition of compatibility formation
Effect.
In the present invention, graceful lettuce juice obtains after directly being squeezed the juice by graceful romaine lettuce.
In the present invention, butterfly lettuce juice obtains after directly being squeezed the juice by green butterfly romaine lettuce.
In the present invention, the aloe barbadensis Miller is the perennial evergreen succulent plant of A Fu flower section's Aloe, is originated in non-
Continent.The Classification system of the aloe barbadensis Miller is Aloe vera L.
In the present invention, aloe barbadensis Miller juice obtains after directly being squeezed the juice by aloe barbadensis Miller.
In the present invention, the oligofructose, abbreviation FOS, also known as Fructooligosaccharides, cane fruit trisaccharide oligosaccharides or sugarcane fruit are oligomeric
Sugar, refer on the residue of fructose of sucrose molecule by ketose made of 1~3 fructosyl of β (1-2) glucosides key connection,
Nystose, sugarcane sugar, six sugar of sugarcane fruit and its mixture.The molecular formula of the oligofructose: GFn, polymerization degree n=2~5.
The oligofructose is the p-type oligofructose of oligofructose content >=90%.The molecular weight of the oligofructose is
100~300 dalton.
1, in composition 1, the weight part ratio respectively prepared between raw material is: graceful 1 parts by weight of lettuce juice, green butterfly romaine lettuce
1 parts by weight of juice, 1 parts by weight of aloe barbadensis Miller juice, 1 parts by weight of oligofructose.
The preparation method of composition 1 includes the following steps:
(1) graceful lettuce juice, green butterfly lettuce juice, aloe barbadensis Miller juice are uniformly mixed according to the ratio；
(2) oligofructose is added to stir evenly to get composition 1.
2, in composition 2, the weight part ratio respectively prepared between raw material is: graceful 3 parts by weight of lettuce juice, green butterfly romaine lettuce
3 parts by weight of juice, 3 parts by weight of aloe barbadensis Miller juice, 20 parts by weight of oligofructose.
The preparation method of composition 1 includes the following steps:
(1) graceful lettuce juice, green butterfly lettuce juice, aloe barbadensis Miller juice are uniformly mixed according to the ratio；
(2) oligofructose is added to stir evenly to get composition 2.
3, in composition 3, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of lettuce juice, green butterfly romaine lettuce
1 parts by weight of juice, 1 parts by weight of aloe barbadensis Miller juice, 5 parts by weight of oligofructose.
The preparation method of composition 1 includes the following steps:
(1) graceful lettuce juice, green butterfly lettuce juice, aloe barbadensis Miller juice are uniformly mixed according to the ratio；
(2) oligofructose is added to stir evenly to get composition 3.
4, the prepared Chinese ink progradation of above-mentioned composition 1, composition 2, composition 3 is investigated, experimental method includes the following steps:
Mouse is divided into three groups, every group 10, is denoted as first group (Embodiment1), second group respectively
(Embodiment2), third group (Embodiment3).
First group (Embodiment1): 1 feeding mouse of composition is used, once a day, and each 3g, continuous feeding one week.One
The diphenoxylate solution of mouse 0.2ml/10g is given after week, three give the prepared Chinese ink containing composition 1 (containing 5% again ten minutes later
Active powdered carbon, 10% gum arabic, surplus be composition 1), after giving prepared Chinese ink 25 minutes cervical dislocation put to death, beat
Abdominal cavity separation mesenterium is opened, clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently pulls into small intestine
Straight line measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".By following public affairs
Formula calculates ink progradation (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
Second group (Embodiment2): 2 feeding mouse of composition is used, once a day, and each 3g, continuous feeding one week.One
The diphenoxylate solution of mouse 0.2ml/10g is given after week, three give the prepared Chinese ink containing composition 2 (containing 5% again ten minutes later
Active powdered carbon, 10% gum arabic, surplus be composition 2), after giving prepared Chinese ink 25 minutes cervical dislocation put to death, beat
Abdominal cavity separation mesenterium is opened, clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently pulls into small intestine
Straight line measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".By following public affairs
Formula calculates ink progradation (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
Third group (Embodiment3): composition 1-3 effective component extracts feeding mouse is used, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
The prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3) of composition 3, gives 25 points of prepared Chinese ink
Cervical dislocation is put to death after clock, is opened abdominal cavity and is separated mesenterium, clip upper end is placed in support from the intestinal tube of pylorus, lower end to ileocecus
On disk, small intestine is gently pulled into straight line and is measured, Length of intestine is " total small intestinal length ", is " ink from pylorus to prepared Chinese ink forward position
Juice promotes length ".Be calculated according to the following formula ink progradation (ink progradation=prepared Chinese ink promote length/total small intestinal length ×
100%).
As shown in figure 5, comparing by ink progradation, composition 2 and composition 3 have conspicuousness compared with composition 1
Difference.
Embodiment 5
Composition 1, composition 2, composition 3 are prepared with method identical with above-described embodiment 4, it is logical then to investigate its ease constipation
Just effect.
Experimental method includes the following steps:
Mouse is divided into three groups, every group 10, is denoted as first group (Embodiment1), second group respectively
(Embodiment2), third group (Embodiment3).
First group (Embodiment1): 1 feeding mouse of composition is used, once a day, and each 3g, continuous feeding one week.One
The diphenoxylate solution of mouse 0.2ml/10g is given after week, three give the prepared Chinese ink containing composition 1 (containing 5% again ten minutes later
Active powdered carbon, 10% gum arabic, surplus be composition 1) stomach-filling, start simultaneously at timing.Every animal is individually raised, and
Supply feed and drinking-water, the defecation water content in observation each group mouse 5 hours.
Second group (Embodiment2): 2 feeding mouse of composition is used, once a day, and each 3g, continuous feeding one week.One
The diphenoxylate solution of mouse 0.2ml/10g is given after week, three give the prepared Chinese ink containing composition 2 (containing 5% again ten minutes later
Active powdered carbon, 10% gum arabic, surplus be composition 2) stomach-filling, start simultaneously at timing.Every animal is individually raised, and
Supply feed and drinking-water, the defecation water content in observation each group mouse 5 hours.
Third group (Embodiment3): using 3 feeding mouse of composition, once a day, each 3g, continuous feeding one week.One
The diphenoxylate solution of mouse 0.2ml/10g is given after week, three give the prepared Chinese ink containing composition 3 (containing 5% again ten minutes later
Active powdered carbon, 10% gum arabic, surplus be composition 3) stomach-filling, start simultaneously at timing.Every animal is individually raised, and
Supply feed and drinking-water, the defecation water content in observation each group mouse 5 hours.
As shown in fig. 6, comparing in excrement water content, composition 2 and composition 3 have significant difference compared with composition 1.
In addition, general by the effect of non-clinical experiment discovery composition 1.The relax bowel and defecation effect of composition 2 is good, still
Mouthfeel is poor, careless fishy smell weight.The relax bowel and defecation effect of composition 3 is more slightly lower than composition 2 but good in taste, therefore composition 3 is most
Excellent combination.
Embodiment 6
In composition 3, bifidobacterium lactis suspension and/or lactobacillus acidophilus suspension is added.
The bifidobacterium lactis suspension is acquisition that bifidobacterium lactis powder is dissolved in the water.The newborn bifid bar of every 1 parts by weight
Contain 1g water and 2000*10 in bacteria suspension8Cfu bifidobacterium lactis.
The lactobacillus acidophilus suspension is acquisition that lactobacillus acidophilus powder is dissolved in the water.The acidophilus cream bar of every 1 parts by weight
Contain 1g water and 1500*10 in bacteria suspension8Cfu lactobacillus acidophilus.
1, in composition 3-1, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly romaine lettuce
1 parts by weight, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 1 parts by weight of bifidobacterium lactis suspension.
The preparation method of composition 3-1 includes the following steps:
In composition 3, bifidobacterium lactis suspension is added according to the ratio to get composition 3-1.
2, in composition 3-2, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly romaine lettuce
1 parts by weight, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 3.3 parts by weight of bifidobacterium lactis suspension.
The preparation method of composition 3-2 includes the following steps:
In composition 3, bifidobacterium lactis suspension is added according to the ratio to get composition 3-2.
3, in composition 3-3, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly romaine lettuce
1 parts by weight, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 5 parts by weight of bifidobacterium lactis suspension.
The preparation method of composition 3-3 includes the following steps:
In composition 3, bifidobacterium lactis suspension is added according to the ratio to get composition 3-3.
4, in composition 3-4, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly romaine lettuce
1 parts by weight, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 1 parts by weight of lactobacillus acidophilus suspension.
The preparation method of composition 3-4 includes the following steps:
In composition 3, lactobacillus acidophilus suspension is added according to the ratio to get composition 3-4.
5, in composition 3-5, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly romaine lettuce
1 parts by weight, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 3.3 parts by weight of lactobacillus acidophilus suspension.
The preparation method of composition 3-5 includes the following steps:
In composition 3, lactobacillus acidophilus suspension is added according to the ratio to get composition 3-5.
6, in composition 3-6, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly romaine lettuce
1 parts by weight, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 5 parts by weight of lactobacillus acidophilus suspension.
The preparation method of composition 3-6 includes the following steps:
In composition 3, lactobacillus acidophilus is added according to the ratio to get composition 3-6.
7, in composition 3-7, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly romaine lettuce
1 parts by weight, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 0.5 parts by weight of bifidobacterium lactis suspension, lactobacillus acidophilus
0.5 parts by weight of suspension.
The preparation method of composition 3-7 includes the following steps:
In composition 3, bifidobacterium lactis suspension and lactobacillus acidophilus suspension are added according to the ratio to get composition 3-7.
8, in composition 3-8, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly romaine lettuce
1 parts by weight, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 1 parts by weight of bifidobacterium lactis suspension, lactobacillus acidophilus are outstanding
1 parts by weight of liquid.
The preparation method of composition 3-8 includes the following steps:
In composition 3, bifidobacterium lactis suspension and lactobacillus acidophilus suspension are added according to the ratio to get composition 3-8.
9, in composition 3-9, the weight part ratio respectively prepared between raw material is: graceful 2 parts by weight of romaine lettuce, green butterfly romaine lettuce
1 parts by weight, 1 parts by weight of aloe barbadensis Miller, 5 parts by weight of oligofructose, 2 parts by weight of bifidobacterium lactis suspension, lactobacillus acidophilus are outstanding
2 parts by weight of liquid.
The preparation method of composition 3-9 includes the following steps:
In composition 3, bifidobacterium lactis suspension and lactobacillus acidophilus suspension are added according to the ratio to get composition 3-9.
Next the function of above-mentioned each composition is investigated.
Mouse is divided into 10 groups, every group 5, is denoted as first group of (1 part of group of bifidobacterium lactis), second group of (newborn bifid respectively
3.3 parts of groups of bacillus), third group (5 parts of groups of bifidobacterium lactis), the 4th group of (1 part of group of lactobacillus acidophilus), the 5th group of (acidophilus cream bar
3.3 parts of groups of bacterium), the 6th group (5 parts of groups of lactobacillus acidophilus), the 7th group (totally 0.5 group), the 8th group (totally 1 group), the 9th group (totally 2
Group), the tenth group (distilled water group).
First group (1 part of group of bifidobacterium lactis): composition 3-1 feeding mouse is used, once a day, and each 3g, continuous feeding
One week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives the ink containing composition 3-1 again after 30 minutes
Juice (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-1), cervical vertebra is de- after giving prepared Chinese ink 25 minutes
Mortar is put to death, and is opened abdominal cavity and is separated mesenterium, and clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently will
Small intestine pulls into straight line and measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".
Ink progradation is calculated according to the following formula (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
Second group (3.3 parts of groups of bifidobacterium lactis): using composition 3-2 feeding mouse, once a day, each 3g is continuous to feed
Food one week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives again after 30 minutes containing composition 3-2's
Prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-2), gives cervical vertebra after prepared Chinese ink 25 minutes
Dislocation is put to death, and is opened abdominal cavity and is separated mesenterium, clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently
Small intestine is pulled into straight line to measure, Length of intestine is " total small intestinal length ", from pylorus to prepared Chinese ink forward position for " prepared Chinese ink promotes length
Degree ".Ink progradation is calculated according to the following formula (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
Third group (5 parts of groups of bifidobacterium lactis): using composition 3-3 feeding mouse, once a day, each 3g, continuous feeding
One week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives the ink containing composition 3-3 again after 30 minutes
Juice (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-3), cervical vertebra is de- after giving prepared Chinese ink 25 minutes
Mortar is put to death, and is opened abdominal cavity and is separated mesenterium, and clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently will
Small intestine pulls into straight line and measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".
Ink progradation is calculated according to the following formula (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
4th group (1 part of group of lactobacillus acidophilus): composition 3-4 feeding mouse is used, once a day, and each 3g, continuous feeding
One week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives the ink containing composition 3-4 again after 30 minutes
Juice (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-4), cervical vertebra is de- after giving prepared Chinese ink 25 minutes
Mortar is put to death, and is opened abdominal cavity and is separated mesenterium, and clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently will
Small intestine pulls into straight line and measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".
Ink progradation is calculated according to the following formula (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
5th group (3.3 parts of groups of lactobacillus acidophilus): using composition 3-5 feeding mouse, once a day, each 3g is continuous to feed
Food one week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives again after 30 minutes containing composition 3-5's
Prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-5), gives cervical vertebra after prepared Chinese ink 25 minutes
Dislocation is put to death, and is opened abdominal cavity and is separated mesenterium, clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently
Small intestine is pulled into straight line to measure, Length of intestine is " total small intestinal length ", from pylorus to prepared Chinese ink forward position for " prepared Chinese ink promotes length
Degree ".Ink progradation is calculated according to the following formula (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
6th group (5 parts of groups of lactobacillus acidophilus): composition 3-6 feeding mouse is used, once a day, and each 3g, continuous feeding
One week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives the ink containing composition 3-6 again after 30 minutes
Juice (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-6), cervical vertebra is de- after giving prepared Chinese ink 25 minutes
Mortar is put to death, and is opened abdominal cavity and is separated mesenterium, and clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently will
Small intestine pulls into straight line and measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".
Ink progradation is calculated according to the following formula (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
7th group (totally 0.5 group): composition 3-7 feeding mouse is used, once a day, and each 3g, continuous feeding one week.One week
The diphenoxylate solution for giving mouse 0.2ml/10g later gives the prepared Chinese ink containing composition 3-7 (containing 5% again after 30 minutes
Active powdered carbon, 10% gum arabic, surplus are composition 3-7), cervical dislocation is put to death after giving prepared Chinese ink 25 minutes, is beaten
Abdominal cavity separation mesenterium is opened, clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently pulls into small intestine
Straight line measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".By following public affairs
Formula calculates ink progradation (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
8th group (totally 1 group): composition 3-8 feeding mouse is used, once a day, and each 3g, continuous feeding one week.One week it
The diphenoxylate solution for giving mouse 0.2ml/10g afterwards gives the prepared Chinese ink containing composition 3-8 (containing 5% work again after 30 minutes
Property powdered carbon, 10% gum arabic, surplus be composition 3-8), after giving prepared Chinese ink 25 minutes cervical dislocation put to death, open
Abdominal cavity separates mesenterium, and clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently pulls into small intestine directly
Line measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".By following equation
Calculate ink progradation (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
9th group (totally 2 groups): composition 3-9 feeding mouse is used, once a day, and each 3g, continuous feeding one week.One week it
The diphenoxylate solution for giving mouse 0.2ml/10g afterwards gives the prepared Chinese ink containing composition 3-9 (containing 5% work again after 30 minutes
Property powdered carbon, 10% gum arabic, surplus be composition 3-9), after giving prepared Chinese ink 25 minutes cervical dislocation put to death, open
Abdominal cavity separates mesenterium, and clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, gently pulls into small intestine directly
Line measures, and Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".By following equation
Calculate ink progradation (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
Tenth group (distilled water group): distilled water feeding mouse is used, once a day, and each 3g, continuous feeding one week.One week it
The diphenoxylate solution for giving mouse 0.2ml/10g afterwards gives the prepared Chinese ink containing distilled water (containing 5% activity again after 30 minutes
Powdered carbon, 10% gum arabic, surplus are distilled water), cervical dislocation is put to death after giving prepared Chinese ink 25 minutes, opens abdominal cavity point
From mesenterium, clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is carried out
Measurement, Length of intestine are " total small intestinal length ", are from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Ink is calculated according to the following formula
Juice propulsion rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
Such as Fig. 7, compare by ink progradation, finds that 3.3 parts by weight of bifidobacterium lactis suspension are added in composition 3
When, the prepared Chinese ink advance rate of mouse has significant difference compared to control group.
Embodiment 7
According to the identical method of embodiment 6, composition 3-1, composition 3-2, composition 3-3, composition 3-4, group are prepared
Close object 3-5, composition 3-6, composition 3-7, composition 3-8, composition 3-9.
Mouse is divided into 10 groups, every group 5, is denoted as first group of (1 part of group of bifidobacterium lactis), second group of (newborn bifid respectively
3.3 parts of groups of bacillus), third group (5 parts of groups of bifidobacterium lactis), the 4th group of (1 part of group of lactobacillus acidophilus), the 5th group of (acidophilus cream bar
3.3 parts of groups of bacterium), the 6th group (5 parts of groups of lactobacillus acidophilus), the 7th group (totally 0.5 group), the 8th group (totally 1 group), the 9th group (totally 2
Group), the tenth group (distilled water group).
First group (1 part of group of bifidobacterium lactis): composition 3-1 feeding mouse is used, once a day, and each 3g, continuous feeding
One week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives the ink containing composition 3-1 again after 30 minutes
Juice (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-1) stomach-filling, starts simultaneously at timing.Every animal
Individually raising, and feed and drinking-water are supplied, the defecation water content in observation each group mouse 5 hours.
Second group (3.3 parts of groups of bifidobacterium lactis): using composition 3-2 feeding mouse, once a day, each 3g is continuous to feed
Food one week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives again after 30 minutes containing composition 3-2's
Prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-2) stomach-filling, starts simultaneously at timing.Every dynamic
Object is individually raised, and supplies feed and drinking-water, the defecation water content in observation each group mouse 5 hours.
Third group (5 parts of groups of bifidobacterium lactis): using composition 3-3 feeding mouse, once a day, each 3g, continuous feeding
One week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives the ink containing composition 3-3 again after 30 minutes
Juice (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-3) stomach-filling, starts simultaneously at timing.Every animal
Individually raising, and feed and drinking-water are supplied, the defecation water content in observation each group mouse 5 hours.
4th group (1 part of group of lactobacillus acidophilus): composition 3-4 feeding mouse is used, once a day, and each 3g, continuous feeding
One week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives the ink containing composition 3-4 again after 30 minutes
Juice (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-4) stomach-filling, starts simultaneously at timing.Every animal
Individually raising, and feed and drinking-water are supplied, the defecation water content in observation each group mouse 5 hours.
5th group (3.3 parts of groups of lactobacillus acidophilus): using composition 3-5 feeding mouse, once a day, each 3g is continuous to feed
Food one week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives again after 30 minutes containing composition 3-5's
Prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-5) stomach-filling, starts simultaneously at timing.Every dynamic
Object is individually raised, and supplies feed and drinking-water, the defecation water content in observation each group mouse 5 hours.
6th group (5 parts of groups of lactobacillus acidophilus): composition 3-6 feeding mouse is used, once a day, and each 3g, continuous feeding
One week.The diphenoxylate solution that mouse 0.2ml/10g is given after one week, gives the ink containing composition 3-6 again after 30 minutes
Juice (active powdered carbon, 10% gum arabic containing 5%, surplus are composition 3-6) stomach-filling, starts simultaneously at timing.Every animal
Individually raising, and feed and drinking-water are supplied, the defecation water content in observation each group mouse 5 hours.
7th group (totally 0.5 group): composition 3-7 feeding mouse is used, once a day, and each 3g, continuous feeding one week.One week
The diphenoxylate solution for giving mouse 0.2ml/10g later gives the prepared Chinese ink containing composition 3-7 (containing 5% again after 30 minutes
Active powdered carbon, 10% gum arabic, surplus are composition 3-7) stomach-filling, start simultaneously at timing.Every animal is individually raised, and
Supply feed and drinking-water, the defecation water content in observation each group mouse 5 hours.
8th group (totally 1 group): composition 3-8 feeding mouse is used, once a day, and each 3g, continuous feeding one week.One week it
The diphenoxylate solution for giving mouse 0.2ml/10g afterwards gives the prepared Chinese ink containing composition 3-8 (containing 5% work again after 30 minutes
Property powdered carbon, 10% gum arabic, surplus be composition 3-8) stomach-filling, start simultaneously at timing.Every animal is individually raised, and supplies
Defecation water content to feed and drinking-water, in observation each group mouse 5 hours.
9th group (totally 2 groups): composition 3-9 feeding mouse is used, once a day, and each 3g, continuous feeding one week.One week it
The diphenoxylate solution for giving mouse 0.2ml/10g afterwards gives the prepared Chinese ink containing composition 3-9 (containing 5% work again after 30 minutes
Property powdered carbon, 10% gum arabic, surplus be composition 3-9) stomach-filling, start simultaneously at timing.Every animal is individually raised, and supplies
Defecation water content to feed and drinking-water, in observation each group mouse 5 hours.
Tenth group (distilled water group): distilled water feeding mouse is used, once a day, and each 3g, continuous feeding one week.One week it
The diphenoxylate solution for giving mouse 0.2ml/10g afterwards gives the prepared Chinese ink containing distilled water (containing 5% activity again after 30 minutes
Powdered carbon, 10% gum arabic, surplus are distilled water) stomach-filling, start simultaneously at timing.Every animal is individually raised, and supplies feeding
Material and drinking-water, the defecation water content in observation each group mouse 5 hours.
As shown in figure 8, comparing by excrement water content, find that 3.3 weight of bifidobacterium lactis suspension is added in composition 3
When part, the water content of the prepared Chinese ink excrement of mouse has significant difference compared to control group.
Embodiment 8
The composition of the present embodiment, the weight part ratio respectively prepared between raw material is: graceful 10 parts by weight of romaine lettuce, green butterfly
5 parts by weight of romaine lettuce, 5 parts by weight of aloe barbadensis Miller, 25 parts by weight of oligofructose, 16.5 parts by weight of bifidobacterium lactis suspension.
The preparation method of the composition of the present embodiment, includes the following steps:
(1) graceful lettuce juice, green butterfly lettuce juice, aloe barbadensis Miller juice are uniformly mixed according to the ratio；
(2) oligofructose is added to stir evenly, adds bifidobacterium lactis suspension to get composition.
20 parts by weight of purified water, 50 parts by weight of purified water, 100 parts by weight of purified water, 120 are respectively adopted in the composition of the present embodiment
Parts by weight of purified water, 150 parts by weight of purified water, 20 parts by weight tap water, 50 parts by weight tap water, 100 parts by weight tap water, 120 weights
Amount part tap water, 150 parts by weight tap water are diluted and carry out relax bowel and defecation effect experiment.
Mouse is divided into 10 groups, every group 5.
First group (from 20 groups) using 20 parts by weight originally water-reducible composition, feeding mouse, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
Using 20 parts by weight originally water-reducible composition prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus be adopt
With 20 parts by weight originally water-reducible composition) give prepared Chinese ink 25 minutes after cervical dislocation put to death, open abdominal cavity and separate intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
Second group (from 50 groups) using 50 parts by weight originally water-reducible composition, feeding mouse, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
Using 50 parts by weight originally water-reducible composition prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus be adopt
With 50 parts by weight originally water-reducible composition) give prepared Chinese ink 25 minutes after cervical dislocation put to death, open abdominal cavity and separate intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
Third group (from 100 groups) is using 100 parts by weight originally water-reducible composition, feeding mouse, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
Using 100 parts by weight originally water-reducible composition prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus be adopt
With 100 parts by weight originally water-reducible composition) give prepared Chinese ink 25 minutes after cervical dislocation put to death, open abdominal cavity and separate intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
4th group (from 120 groups) using 120 parts by weight originally water-reducible composition, feeding mouse, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
Using 120 parts by weight originally water-reducible composition prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus be adopt
With 120 parts by weight originally water-reducible composition) give prepared Chinese ink 25 minutes after cervical dislocation put to death, open abdominal cavity and separate intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
5th group (from 150 groups) using 150 parts by weight originally water-reducible composition, feeding mouse, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
Using 150 parts by weight originally water-reducible composition prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus be adopt
With 150 parts by weight originally water-reducible composition) give prepared Chinese ink 25 minutes after cervical dislocation put to death, open abdominal cavity and separate intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
6th group (pure 20 groups) use the pure water-reducible composition of 20 parts by weight, feeding mouse, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
Using the pure water-reducible composition of 150 parts by weight prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus be adopt
With the pure water-reducible composition of 150 parts by weight) give prepared Chinese ink 25 minutes after cervical dislocation put to death, open abdominal cavity separate intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
7th group (pure 50 groups) use the pure water-reducible composition of 50 parts by weight, feeding mouse, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
Using the pure water-reducible composition of 50 parts by weight prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus be adopt
With the pure water-reducible composition of 50 parts by weight) give prepared Chinese ink 25 minutes after cervical dislocation put to death, open abdominal cavity separate intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
8th group (pure 100 groups) use the pure water-reducible composition of 100 parts by weight, feeding mouse, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
Using the pure water-reducible composition of 100 parts by weight prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus be adopt
With the pure water-reducible composition of 100 parts by weight) give prepared Chinese ink 25 minutes after cervical dislocation put to death, open abdominal cavity separate intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
9th group (pure 120 groups) use the pure water-reducible composition of 120 parts by weight, feeding mouse, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
Using the pure water-reducible composition of 120 parts by weight prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus be adopt
With the pure water-reducible composition of 120 parts by weight) give prepared Chinese ink 25 minutes after cervical dislocation put to death, open abdominal cavity separate intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
Tenth group (pure 150 groups) use the pure water-reducible composition of 150 parts by weight, feeding mouse, once a day, every time
3g, continuous feeding one week.Give the diphenoxylate solution of mouse 0.2ml/10g after one week, three give again ten minutes later containing
Using the pure water-reducible composition of 150 parts by weight prepared Chinese ink (active powdered carbon, 10% gum arabic containing 5%, surplus be adopt
With the pure water-reducible composition of 150 parts by weight) give prepared Chinese ink 25 minutes after cervical dislocation put to death, open abdominal cavity separate intestines
Mesentery, clip upper end are placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, and small intestine is gently pulled into straight line and is measured,
Length of intestine is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Prepared Chinese ink is calculated according to the following formula to push away
Into rate (ink progradation=prepared Chinese ink promotes length/total small intestinal length × 100%).
As shown in figure 9, tap water effect is slightly less than pure water in proportion for discovery, contained chlorine, calcium in tap water can be
Plasma affects the effect of composition.Therefore, the purified water crossed when large-scale production preferably with reverse osmosis treatment, and 100
The mixed proportion of parts by weight of purified water is slightly more better.
Embodiment 9
Composition is prepared according to identical method in embodiment 8, and it is pure that 20 parts by weight pure water, 50 parts by weight are respectively adopted
Water, 100 parts by weight of purified water, 120 parts by weight of purified water, 150 parts by weight of purified water are diluted composition, obtain 20 parts by weight respectively
The composition after composition, the dilution of 50 parts by weight pure water after pure water dilution, the combination after the dilution of 100 parts by weight pure water
Composition after object, the dilution of 150 parts by weight pure water.
It is diluted and carries out relax bowel and defecation effect experiment, effect of relaxing bowel research, 100 parts by weight are verified in clinical test
The relax bowel and defecation effect of composition after pure water dilution is as shown in table 1 below:
Table 1
As can be seen from Table 1, constipation patient test total number of persons is 100 people, after taking the dilution of 100 parts by weight pure water
It is 8 people that number of the invalid symptom without mitigation is reacted after composition one month, and the number of inefficiency 8%, effective symptom mitigation is
92 people, effective percentage are 92%, and with 78 people of number that effective symptom obviously disappears, obvious effective rate 78% reacts the people of side effect
Number is 0 people, without side-effects, and test result shows that the row of stomach can be increased by taking the composition after 100 parts by weight pure water dilute
Empty rate promotes enterogastric peristalsis, can reach the effect for alleviating constipation.
In addition, another group, it is 100 people that constipation patient, which tests total number of persons, the group after taking the dilution of 20 parts by weight pure water
It is 15 people that number of the invalid symptom without mitigation is reacted after closing object one month, and the number of inefficiency 15%, effective symptom mitigation is
84 people, effective percentage are 84%, and with 61 people of number that effective symptom obviously disappears, obvious effective rate 61% reacts the people of side effect
Number is 0 people, without side-effects, and test result shows that the row of stomach can be increased by taking the composition after 20 parts by weight pure water dilute
Empty rate promotes enterogastric peristalsis, can reach the effect for alleviating constipation.
Another group, it is 100 people that constipation patient, which tests total number of persons, the composition one after taking the dilution of 50 parts by weight pure water
It is 14 people that number of the invalid symptom without mitigation is reacted after a month, and inefficiency 14%, the number that effective symptom mitigates is 81 people, is had
Efficiency is 81%, and with 62 people of number that effective symptom obviously disappears, obvious effective rate 62%, the number for reacting side effect is 0 people,
Without side-effects, test result shows that the Emptying Rate of stomach can be increased by taking the composition after 50 parts by weight pure water dilute, and be promoted
Enterogastric peristalsis can reach the effect for alleviating constipation.
Another group, it is 100 people that constipation patient, which tests total number of persons, the composition after taking the dilution of 120 parts by weight pure water
It is 12 people that number of the invalid symptom without mitigation is reacted after one month, and inefficiency 12%, the number that effective symptom mitigates is 78 people,
Effective percentage is 78%, and with 59 people of number that effective symptom obviously disappears, obvious effective rate 59%, the number for reacting side effect is 0
People, without side-effects, test result shows that the Emptying Rate of stomach can be increased by taking the composition after 120 parts by weight pure water dilute,
Promote enterogastric peristalsis, can reach the effect for alleviating constipation.
Another group, it is 100 people that constipation patient, which tests total number of persons, the composition after taking the dilution of 150 parts by weight pure water
It is 10 people that number of the invalid symptom without mitigation is reacted after one month, and inefficiency 10%, the number that effective symptom mitigates is 88 people,
Effective percentage is 88%, and with 72 people of number that effective symptom obviously disappears, obvious effective rate 72%, the number for reacting side effect is 0
People, without side-effects, test result shows that the Emptying Rate of stomach can be increased by taking the composition after 150 parts by weight pure water dilute,
Promote enterogastric peristalsis, can reach the effect for alleviating constipation.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of composition, preparing raw material includes: graceful lettuce juice, green butterfly lettuce juice, aloe barbadensis Miller juice, oligofructose.
2. composition according to claim 1, which is characterized in that including any one of following characteristics or multinomial: (1) institute
It states after graceful lettuce juice is directly squeezed the juice by graceful romaine lettuce and obtains；(2) the green butterfly lettuce juice obtains after directly being squeezed the juice by green butterfly romaine lettuce
?；(3) the aloe barbadensis Miller juice obtains after directly being squeezed the juice by aloe barbadensis Miller；(4) molecular weight of the oligofructose is 180
~300 dalton.
3. composition according to claim 1, which is characterized in that in the composition, respectively prepare the weight between raw material
Number proportional region is: graceful lettuce juice 1-3 parts by weight, green butterfly lettuce juice 1-3 parts by weight, aloe barbadensis Miller juice 1-3 parts by weight,
Oligofructose 1-20 parts by weight.
4. composition according to claim 1, which is characterized in that in the composition, respectively prepare the weight between raw material
Number ratio is: graceful 2 parts by weight of lettuce juice, green 1 parts by weight of butterfly lettuce juice, 1 parts by weight of aloe barbadensis Miller juice, oligofructose 5
Parts by weight.
5. composition according to claim 1, which is characterized in that further include probiotics in the composition.
6. composition according to claim 5, which is characterized in that the probiotics is selected from bifidobacterium lactis, acidophilus cream bar
Bacterium.
7. composition according to claim 1, which is characterized in that further include any one of following characteristics or multinomial: (1)
The raw material for preparing of the composition further includes bifidobacterium lactis suspension 1-5 parts by weight；(2) raw material for preparing of the composition also wraps
Include lactobacillus acidophilus suspension 1-5 parts by weight；(3) raw material for preparing of the composition further includes bifidobacterium lactis suspension 0.5-2 weight
Measure part, lactobacillus acidophilus suspension 0.5-2 parts by weight.
8. composition according to claim 1, which is characterized in that further include any one of following characteristics or multinomial: (1)
The bifidobacterium lactis suspension is acquisition that bifidobacterium lactis powder is dissolved in the water；(2) the lactobacillus acidophilus suspension be will be thermophilic
Lactobacillus lactis powder is dissolved in the water acquisition.
9. the preparation method of composition as described in claim any one of 1-8 includes the following steps: to mix each raw material for preparing
It is even to get composition.
10. the purposes that the composition as described in claim any one of 1-8 is used to prepare relax bowel and defecation product.
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