CN103230012B - Honeycomb essence buccal tablet and preparation process thereof - Google Patents
Honeycomb essence buccal tablet and preparation process thereof Download PDFInfo
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- CN103230012B CN103230012B CN201310167273.0A CN201310167273A CN103230012B CN 103230012 B CN103230012 B CN 103230012B CN 201310167273 A CN201310167273 A CN 201310167273A CN 103230012 B CN103230012 B CN 103230012B
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Abstract
The invention discloses a honeycomb essence buccal tablet and a preparation process thereof, belonging to the technical field of honeycomb preparation. The honeycomb essence buccal tablet disclosed by the invention is prepared from ultra-fine powder of a honeycomb essence composition, a filling agent, a sweetening agent, an acidulant, edible essence and a lubricating agent. The invention further provides the preparation process of the honeycomb essence buccal tablet. The honeycomb essence buccal tablet disclosed by the invention has the characteristics of being easy for taking, good in mouth feel and rapid in absorption and is capable of overcoming the disadvantages of being insufficient in honeycomb mouth feel and lower in absorption utilization rate, and obviously increasing the absorption utilization rates of effective components in the honeycomb essence; and the honeycomb essence buccal tablet has important value and contribution for clinical treatment, health care and prevention of nasopharyngitis.
Description
Technical field
The invention belongs to technical field of honeycomb preparation, more specifically relate to a kind of honeycomb essence buccal tablet and preparation technology thereof.
Background technology
Honeycomb is the place that honeybee breeds that offspring stocks grain, maintains honeybee husks (similar animal placenta), the propolis of natural anti-inflammatory effect, royal jelly containing the rare anticancer Fungicidal substance 10-hydroxyl caproleic acid (being commonly called as royal jelly acid) of occurring in nature, has the multiple particular matter such as Bee Pollen, beeswax of the title of " concentrated nutrition library " in honeycomb.The composition of honeycomb is very complicated, and main component comprises: the material that aliphatic acid, tannin, glucoside, protein, amino acid, taurine, enzyme, trace element and many compositions are not bright.Modem medical science research finds, honeycomb has good result for treatment rhinitis chronic, nasosinusitis, nose sensitivity, allergic rhinitis and chronic pharyngitis etc., can alleviate rapidly the symptoms such as the throat discomfort because all kinds of nasopharyngitis causes, nasal obstruction, runny nose, headache and dizziness.
Before bimillennium, the effect just having recognized that honeycomb among the people, people are by direct chewing honeycomb, and pharynx juice scum method, utilizes honeycomb to treat nasopharyngitis.But pharynx juice scum method, make a lot of active ingredients in honeycomb cannot absorb by human body, cause larger waste; Meanwhile, because the mouthfeel of honeycomb is pained, and sometimes also have the hygienic issues such as residual honeybee children pupa in honeycomb, the masses limiting honeycomb to a great extent promote.
For solving the problem, in conjunction with modern food processing technology, the extracts active ingredients in honeycomb is refined into honeycomb element by people, and then develops the products such as beehive tea, honeycomb pleasure, honeycomb element cream, honeycomb powder capsule.But no matter be beehive tea, honeycomb pleasure, honeycomb element cream or honeycomb powder capsule, the eating method of these products is all drink by being watered or swallowing, honeycomb element be effectively divided into by after the absorbed organ such as human intestines and stomach and liver, nasopharynx pathological tissues is arrived through body-internal-circulation, absorption rate is lower, well cannot play effect that product is treated nasopharynx.
Honeycomb element is made buccal tablet to be both conducive to improving the bad mouthfeel of honeycomb, be conducive to again honeycomb element long duration of action in the pathological tissues of nasal cavity or throat, give full play to the therapeutic efficiency of honeycomb element for nasopharyngitis, solve above drawback.
Have not yet to see report prepared by honeycomb essence buccal tablet.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of good mouthfeel, is easy to absorption, instant, the significant honeycomb essence buccal tablet of effect, and this buccal tablet can overcome deficiency in honeycomb mouthfeel and the lower drawback of absorption rate.
Present invention also offers a kind of preparation technology of honeycomb essence buccal tablet.
For solving the problems of the technologies described above, the technical scheme that the present invention takes is:
A kind of honeycomb essence buccal tablet, this honeycomb essence buccal tablet is made up of the raw material of following weight parts: honeycomb element composition Ultramicro-powder 20 ~ 80 parts, filler 15 ~ 78 parts, sweetener 0.02 ~ 1.5 part, acid 0.2 ~ 2 part, flavoring essence 0.05 ~ 0.5 part, lubricant 0.8 ~ 2 part;
Wherein, described honeycomb element composition Ultramicro-powder is the Ultramicro-powder be made up of the mixture of honeycomb element freeze-dried powder and yam flour, and its fineness is 3000 ~ 3500 orders, and granularity is 5 ~ 4.5 μm.
Further, described honeycomb element freeze-dried powder and the preferred mass of yam flour are than being 1:0.2 ~ 0.5.
The honeycomb element freeze-dried powder that the present invention uses can by buy honeycomb conventionally in disclosed in after method prepares honeycomb element (i.e. honeycomb extract), recycle freeze drying process of the prior art and prepare freeze-dried powder.In order to reach better product effect, the present invention there is provided herein the preparation method of a kind of honeycomb element and freeze-dried powder thereof:
(1) honeycomb alcohol extract B is extracted: after honeycomb is freezing under-15 DEG C ~-18 DEG C conditions, extractor is dropped into after being ground into meal, add the edible alcohol of its volume 3 ~ 4 times, 10 DEG C ~ 25 DEG C are soaked and stir 72 ~ 96 hours with the rotating speed of 10 ~ 12 revs/min, through 60 ~ 80 order plate-frame filterings, obtain filter residue A, filtrate is 0.085 ~ 0.09MPa in vacuum, temperature is under the condition of 45 DEG C ~ 55 DEG C, obtains honeycomb alcohol extract B after Vacuum Concentration;
(2) honeycomb water extract C is extracted: filter residue A is dropped into extractor, and add the pure water of its quality 6 ~ 7 times, 80 DEG C ~ 85 DEG C are soaked and stir 6 ~ 7 hours with the rotating speed of 10 ~ 12 revs/min, through 60 ~ 80 order plate-frame filterings, remove filter residue, filtrate is 0.085 ~ 0.09MPa in vacuum, and temperature is under the condition of 65 DEG C ~ 70 DEG C, obtains honeycomb water extract C after Vacuum Concentration;
(3) honeycomb element freeze-dried powder is prepared: mixed and obtain honeycomb element by honeycomb alcohol extract B and honeycomb water extract C, this honeycomb element is put into vacuum freeze, first precooling, temperature is-2 DEG C ~-10 DEG C, time is 1 ~ 1.5 hour, sharp freezing again, temperature is-10 DEG C ~-45 DEG C, and the time is 0.5 ~ 4 hour, then vacuumize and heat, vacuum is 40 ~ 0.05 millimetress of mercury, and heating-up temperature is 15 ~ 20 DEG C, obtains honeycomb element freeze-dried powder.
Further, in above-mentioned honeycomb essence buccal tablet, described filler is the mixture of one or more in sucrose, starch, dextrin, corn dextrin, improvement dextrin, glucose, lactose, maltitol, sorbierite, xylitol, sweet mellow wine, compound sugar, hydroxyl isomaltulose or trehalose;
Described sweetener is that Aspartame, knob are sweet, the mixture of one or more in Sucralose, stevioside or glycyrrhizin;
Described acid is the mixture of one or more in citric acid, tartaric acid, malic acid or lactic acid;
Described lubricant is dolomol; And according to the needs of different taste, add the flavoring essence of all kinds of taste.
Honeycomb essence buccal tablet of the present invention can adopt the buccal tablet preparation technology of routine of the prior art to process, and in order to obtain better product effect, the present invention additionally provides a kind of preferred preparation technology at this, and this technique comprises the steps:
(1) prefabricated honeycomb element composition Ultramicro-powder;
(2) 80 mesh sieves are crossed after above-mentioned filler, acid pulverizer being pulverized for subsequent use;
(3) honeycomb element composition Ultramicro-powder, sweetener and the filler after pulverizing, acid are poured in agitator groove together and stirred;
(4) ethanol water uniformly sprayed the mixed material surface described in step (3) with sprayer, and constantly stir and make it to mix, obtain softwood;
(5) softwood made being crossed 20 order stainless (steel) wires granulations with waving comminutor, drying, with the whole grain of 16 order stainless (steel) wire, obtaining dry particle;
(6) get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, with sprayer, flavoring essence is uniformly sprayed in dry fine silt surface, the dry fine silt of spray coated flavoring essence, dry particle and lubricant (being preferably dolomol) are mixed;
(7) compressing tablet, obtains finished product after damp-prrof packing.
Further, in described step (4), the concentration of ethanol water is preferably 30% ~ 60%, and the consumption of ethanol water is preferably 5.5% ~ 12% of honeycomb essence buccal tablet composition of raw materials gross weight.
In step (1), the method for described prefabricated honeycomb element composition Ultramicro-powder is specially:
(1) honeycomb alcohol extract B is extracted: after honeycomb is freezing under-15 DEG C ~-18 DEG C conditions, extractor is dropped into after being ground into meal, add the edible alcohol of its volume 3 ~ 4 times, 10 DEG C ~ 25 DEG C are soaked and stir 72 ~ 96 hours with the rotating speed of 10 ~ 12 revs/min, through 60 ~ 80 order plate-frame filterings, obtain filter residue A, filtrate is 0.085 ~ 0.09MPa in vacuum, temperature is under the condition of 45 DEG C ~ 55 DEG C, obtains honeycomb alcohol extract B after Vacuum Concentration;
(2) honeycomb water extract C is extracted: filter residue A is dropped into extractor, and add the pure water of its quality 6 ~ 7 times, 80 DEG C ~ 85 DEG C are soaked and stir 6 ~ 7 hours with the rotating speed of 10 ~ 12 revs/min, through 60 ~ 80 order plate-frame filterings, remove filter residue, filtrate is 0.085 ~ 0.09MPa in vacuum, and temperature is under the condition of 65 DEG C ~ 70 DEG C, obtains honeycomb water extract C after Vacuum Concentration;
(3) honeycomb element freeze-dried powder is prepared: mixed and obtain honeycomb element by honeycomb alcohol extract B and honeycomb water extract C, this honeycomb element is put into vacuum freeze, first precooling, temperature is-2 DEG C ~-10 DEG C, time is 1 ~ 1.5 hour, sharp freezing again, temperature is-10 DEG C ~-45 DEG C, and the time is 0.5 ~ 4 hour, then vacuumize and heat, vacuum is 40 ~ 0.05 millimetress of mercury, and heating-up temperature is 15 DEG C ~ 20 DEG C, obtains honeycomb element freeze-dried powder;
(4) honeycomb element composition Ultramicro-powder is prepared: be that 1:0.2 is placed in trough type mixing machine by honeycomb element freeze-dried powder and yam flour according to mass ratio, mix 20 ~ 30 minutes, Universalpulverizer is used to pulverize once in this mixture, again the mixture after above-mentioned pulverizing is placed in micronizer to pulverize, compressed air pressure is adjusted to 10MPa, obtains the honeycomb element composition Ultramicro-powder of fineness 3000 ~ 3500 order, granularity 5 ~ 4.5 μm.
Beneficial effect of the present invention is:
(1) the present invention adds the ultramicro grinding that yam flour is conducive to honeycomb element when preparing honeycomb element composition Ultramicro-powder: the existence of honeycomb alcohol extract in due to honeycomb element freeze-dried powder, when using micronizer to pulverize, difficult feed, crush efficiency is low, and after pulverizing, particle is still comparatively large, and its fineness is about 300 orders; Yam flour is fully pulverized with honeycomb element freeze-dried powder, mixed; fully to absorb the grease and stickum that are wherein unfavorable for pulverizing; make it go for the broken technique of air blast ultramicro powder and obtain honeycomb element composition Ultramicro-powder, stable process conditions used, be applicable to large-scale industrial and produce.
(2) the present invention can improve the therapeutic efficiency of honeycomb element to nasopharyngitis effectively: the eating method of traditional honeycomb element product is generally containing clothes, is watered and takes or water distribution is swallowed, the active ingredient of honeycomb element is primarily of after intestinal absorption, enter body inner blood circulating through capillary and deliver to whole body, then remake the pathological tissues for nasal cavity, throat, utilization rate is lower, cannot fully play the therapeutic efficiency of honeycomb element to nasopharyngitis.And honeycomb element is prepared into buccal tablet, change owing to containing slowly, the honeycomb element energy long period rests on oral cavity and continues to play drug effect, and the fineness due to honeycomb element reaches 3000 ~ 3500 orders, the active ingredient of honeycomb element directly can be absorbed by pathological tissues, avoiding the loss of active ingredient by producing during the absorbed organ such as human intestines and stomach, effectively improve the absorption rate of honeycomb element active ingredient.Therefore, honeycomb essence buccal tablet of the present invention has important value and contribution for nasopharyngitis clinical treatment and health care prevention.
(3) the present invention is conducive to the audient crowd expanding honeycomb element product: because honeycomb element mouthfeel is pained, be not suitable for directly taking, honeycomb element product common on market be honeycomb element and honey, Bee Pollen, royal jelly, propolis are allocated mix after make honeycomb element cream; Honeycomb element cream due to honey content higher, diabetic group does not use.This product adds sweetener, acid, flavoring essence etc. and carried out seasoning to honeycomb element in mouthfeel, makes honeycomb element tasty, unique flavor; If when selecting maltitol, sorbierite, xylitol, sweet mellow wine, hydroxyl isomaltulose wherein one or more for filler in formula, product then can be used as sugarfree foods for diabetes patient simultaneously, thus the audient crowd of expansion honeycomb element product.
(4) there is not the injury of synthetic drug treatment to body in product of the present invention, and can have good repair to histocyte in damaged condition: honeycomb element is the pollution-free food of pure natural, the materials such as the propolis in honeycomb element have to bacterium, fungi, virus the effect suppressing and kill; In honeycomb element, royal jelly, pollen compound nutritional composition, can fully promote that immune function of human body improves, make nasopharyngitis patients symptomatic relief and disappear.
Detailed description of the invention
According to weight parts, honeycomb essence buccal tablet is prepared by following raw materials according: honeycomb element composition Ultramicro-powder 20 ~ 80 parts, filler 15 ~ 78 parts, sweetener 0.02 ~ 1.5 part, acid 0.2 ~ 2 part, flavoring essence 0.05 ~ 0.5 part, lubricant 0.8 ~ 2 part; Wherein, described honeycomb element composition Ultramicro-powder is the Ultramicro-powder be made up of the mixture of honeycomb element freeze-dried powder and yam flour, and its fineness is 3000 ~ 3500 orders, and granularity is 5 ~ 4.5 μm.Described honeycomb element freeze-dried powder is 1:0.2 ~ 0.5 with the preferred mass ratio of yam flour.
Filler can be the mixture of one or more of sucrose, starch, dextrin, corn dextrin, improvement dextrin, glucose, lactose, maltitol, sorbierite, xylitol, sweet mellow wine, compound sugar, hydroxyl isomaltulose or trehalose;
Sweetener can be that Aspartame, knob are sweet, the mixture of one or more in Sucralose, stevioside or glycyrrhizin;
Acid can be the mixture of one or more in citric acid, tartaric acid, malic acid or lactic acid;
Lubricant is dolomol.
According to described pulp furnish, preparation technology comprises:
1. prefabricated honeycomb element composition Ultramicro-powder;
2. 80 mesh sieves are crossed after filler, acid pulverizer being pulverized for subsequent use;
3. honeycomb element composition Ultramicro-powder, sweetener and the filler after pulverizing, acid are poured in agitator groove together and stirred;
4. with sprayer, ethanol water is uniformly sprayed in the 3. described mixed material surface of step, and constantly stirring makes it to mix, and obtains softwood;
5. the softwood made being crossed 20 order stainless (steel) wires granulations with waving comminutor, drying, with the whole grain of 16 order stainless (steel) wire, obtaining dry particle;
6. get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, flavoring essence is uniformly sprayed in dry fine silt surface, by even to the dry fine silt of spray coated flavoring essence, dry particle and mix lubricant with sprayer;
7. compressing tablet, obtains finished product after damp-prrof packing.
The honeycomb essence buccal tablet more than prepared can add the honeycomb essence buccal tablet that different taste produced by all kinds of flavoring essence.
The concrete grammar of prefabricated honeycomb element composition Ultramicro-powder comprises:
1. honeycomb alcohol extract B is extracted: after honeycomb is freezing under-15 DEG C ~-18 DEG C conditions, extractor is dropped into after being ground into meal, add the edible alcohol of its volume 3 ~ 4 times, 10 DEG C ~ 25 DEG C are soaked and stir 72 ~ 96 hours with the rotating speed of 10 ~ 12 revs/min, through 60 ~ 80 order plate-frame filterings, obtain filter residue A, filtrate is 0.085 ~ 0.09MPa in vacuum, temperature is under the condition of 45 ~ 55 DEG C, obtains honeycomb alcohol extract B after Vacuum Concentration;
2. honeycomb water extract C is extracted: filter residue A is dropped into extractor, and add the pure water of its quality 6 ~ 7 times, 80 ~ 85 DEG C are soaked and stir 6 ~ 7 hours with the rotating speed of 10 ~ 12 revs/min, through 60 ~ 80 order plate-frame filterings, remove filter residue, filtrate is 0.085 ~ 0.09MPa in vacuum, and temperature is under the condition of 65 ~ 70 DEG C, obtains honeycomb water extract C after Vacuum Concentration;
3. honeycomb element freeze-dried powder is prepared: mixed by honeycomb alcohol extract B and honeycomb water extract C, put into vacuum freeze, first precooling after pouring the honeycomb extract mixed into tray, temperature is-2 DEG C ~-10 DEG C, time is 1 ~ 1.5 hour, sharp freezing again, temperature is-10 DEG C ~-45 DEG C, and the time is 0.5 ~ 4 hour, then vacuumize and heat, vacuum is 40 ~ 0.05 millimetress of mercury, and heating-up temperature is 15 ~ 20 DEG C, obtains honeycomb extract freeze-drying powder;
4. honeycomb element composition Ultramicro-powder is prepared: put in trough type mixing machine by honeycomb extract freeze-drying powder, yam flour (mass ratio is 1:0.2), mix 20 ~ 30 minutes, Universalpulverizer is used to pulverize once in this mixture, again the mixture after above-mentioned pulverizing is placed in micronizer to pulverize, compressed air pressure is adjusted to 10MPa, obtains the honeycomb element composition Ultramicro-powder of fineness 3000 ~ 3500 order, granularity 5 ~ 4.5 μm.
Be below several embodiments of the present invention, further illustrate the present invention, but the present invention is not limited only to this.
Embodiment 1
1. each raw material is taken in proportion
Honeycomb element composition Ultramicro-powder 41 parts, filler xylitol 55 parts, sweetener Aspartame 1.2 parts, acid citric acid 1.5 parts, 0.3 part, orange taste essence, dolomol 1 part;
2. for subsequent use by crossing 80 mesh sieves after 55 parts of xylitols, 1.5 parts of citric acid pulverizers pulverizing;
In 3. above-mentioned raw materials being filled a prescription: the xylitol 55 parts after honeycomb element composition Ultramicro-powder 41 parts, Aspartame 1.2 parts, pulverizing, citric acid 1.5 parts are poured in agitator groove together and are stirred;
4. 40% ethanol water uniformly sprayed in the 3. described mixed material surface of step with sprayer and be constantly uniformly mixed, be that hand is pinched agglomerating to mixed material, one pushes away namely loose state, the consumption of described 40% ethanol water be step 1. in raw materials used total formula weight 7.2%;
5. softwood step 4. made crosses 20 order stainless (steel) wires granulations with waving comminutor, dries, with the whole grain of 16 order stainless (steel) wire, obtains dry particle;
6. get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, with sprayer, essence is uniformly sprayed in dry fine silt surface, the dolomol of the dry fine silt of spray coated essence, dry particle and 1 part is mixed;
7. compressing tablet, obtains finished product after damp-prrof packing.
Embodiment 2
1. each raw material is taken in proportion
Honeycomb element composition Ultramicro-powder 50 parts, filler glucose 47 parts, sweet 0.9 part of sweetener knob, acid malic acid 0.6 part, flavoring apple essence 0.4 part, dolomol 1.1 parts;
2. for subsequent use by crossing 80 mesh sieves after 47 parts of glucose, 0.6 part of malic acid pulverizer pulverizing;
In 3. above-mentioned raw materials being filled a prescription: the glucose 47 parts after sweet 0.9 part of honeycomb element composition Ultramicro-powder 50 parts, knob, pulverizing, malic acid 0.6 part are poured in agitator groove together and are stirred;
4. 35% ethanol water uniformly sprayed in the 3. described mixed material surface of step with sprayer and be constantly uniformly mixed, be that hand is pinched agglomerating to mixed material, one pushes away namely loose state, the consumption of described 35% ethanol water be step 1. in raw materials used total formula weight 9.6%;
5. softwood step 4. made crosses 20 order stainless (steel) wires granulations with waving comminutor, dries, with the whole grain of 16 order stainless (steel) wire, obtains dry particle;
6. get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, with sprayer, essence is uniformly sprayed in dry fine silt surface, the dolomol of the dry fine silt of spray coated essence, dry particle and 1.1 parts is mixed;
7. compressing tablet, obtains finished product after damp-prrof packing.
Embodiment 3
1. each raw material is taken in proportion
Honeycomb element composition Ultramicro-powder 70 parts, filler D-sorbite 28 parts, Sweetener Sucralose 0.07 part, 0.6 part, acid tartaric acid, grape essence 0.53 part, dolomol 0.8 part;
2. for subsequent use by crossing 80 mesh sieves after 28 parts of D-sorbites, 0.6 part of tartaric acid pulverizer pulverizing;
In 3. above-mentioned raw materials being filled a prescription: the D-sorbite 28 parts after honeycomb element composition Ultramicro-powder 70 parts, Sucralose 0.07 part, pulverizing, 0.6 part, tartaric acid are poured in agitator groove together and are stirred;
4. 55% ethanol water uniformly sprayed in the 3. described mixed material surface of step with sprayer and be constantly uniformly mixed, be that hand is pinched agglomerating to mixed material, one pushes away namely loose state, the consumption of described 60% ethanol water be step 1. in raw materials used total formula weight 10.6%;
5. softwood step 4. made crosses 20 order stainless (steel) wires granulations with waving comminutor, dries, with the whole grain of 16 order stainless (steel) wire, obtains dry particle;
6. get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, with sprayer, essence is uniformly sprayed in dry fine silt surface, the dolomol of the dry fine silt of spray coated essence, dry particle and 0.8 part is mixed;
7. compressing tablet, obtains finished product after damp-prrof packing.
Embodiment 4
1. each raw material is taken in proportion
Honeycomb element composition Ultramicro-powder 20 parts, 78 parts, the mixture of one or both any ratios of filler sucrose or lactose, sweetener glycyrrhizin 0.2 part, acid lactic acid 0.4 part, milk flavour 0.5 part, dolomol 0.9 part;
2. by the mixture of one or both any ratios of 78 portions of sucrose or lactose, that 0.4 part of lactic acid pulverizer crosses 80 mesh sieves after pulverizing is for subsequent use;
In 3. above-mentioned raw materials being filled a prescription: 78 parts, mixture, the lactic acid 0.4 part of the sucrose after honeycomb element composition Ultramicro-powder 20 parts, glycyrrhizin 0.2 part, pulverizing or one or both any ratios of lactose are poured in agitator groove together and are stirred;
4. 30% ethanol water uniformly sprayed in the 3. described mixed material surface of step with sprayer and be constantly uniformly mixed, be that hand is pinched agglomerating to mixed material, one pushes away namely loose state, the consumption of described 30% ethanol water be step 1. in raw materials used total formula weight 12%;
5. softwood step 4. made crosses 20 order stainless (steel) wires granulations with waving comminutor, dries, with the whole grain of 16 order stainless (steel) wire, obtains dry particle;
6. get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, with sprayer, essence is uniformly sprayed in dry fine silt surface, the dolomol of the dry fine silt of spray coated essence, dry particle and 0.9 part is mixed;
7. compressing tablet, obtains finished product after damp-prrof packing.
Embodiment 5
1. each raw material is taken in proportion
Honeycomb element composition Ultramicro-powder 78 parts, 18 parts, the mixture of one or more any ratios in filler starch, dextrin, corn dextrin, improvement dextrin, sweetener knob is sweet, 0.7 part, the mixture of one or both any ratios of Aspartame, 1.3 parts, the mixture of acid citric acid or one or both any ratios of malic acid, Mint Essence 0.4 part, lemon extract 0.08 part, 0.02 part, American Ginseng essence, dolomol 1.5 parts;
2. by for subsequent use for the rear mistake of mixture pulverizer pulverizing 80 mesh sieves of 1.3 parts of citric acids or one or both any ratios of malic acid;
3. in above-mentioned raw materials being filled a prescription: honeycomb element composition Ultramicro-powder 78 parts, knob are sweet, 18 parts, the mixture of one or more any ratios in 0.7 part, the mixture of one or both any ratios of Aspartame, starch, dextrin, corn dextrin, improvement dextrin, pulverize after citric acid or 1.3 parts, the mixture of one or both any ratios of malic acid pour in agitator groove together and stir;
4. 60% ethanol water uniformly sprayed in the 3. described mixed material surface of step with sprayer and be constantly uniformly mixed, be that hand is pinched agglomerating to mixed material, one pushes away namely loose state, the consumption of described 60% ethanol water be step 1. in raw materials used total formula weight 5.5%;
5. softwood step 4. made crosses 20 order stainless (steel) wires granulations with waving comminutor, dries, with the whole grain of 16 order stainless (steel) wire, obtains dry particle;
6. get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, with sprayer, essence is uniformly sprayed in dry fine silt surface, the dolomol of the dry fine silt of spray coated essence, dry particle 1.5 parts is mixed;
7. compressing tablet, obtains finished product after damp-prrof packing.
Embodiment 6
1. each raw material is taken in proportion
Honeycomb element composition Ultramicro-powder 30 parts, filler trehalose 67 parts, sweetener stevioside 0.7 part, 0.7 part, the mixture of acid citric acid or one or both any ratios of malic acid, vanilla 0.2 part, dolomol 1.4 parts;
2. for subsequent use by crossing 80 mesh sieves after 67 portions of trehaloses, 0.7 part of acid pulverizer pulverizing;
In 3. above-mentioned raw materials being filled a prescription: 0.7 part, the mixture of one or both any ratios of trehalose 67 parts, citric acid or malic acid after honeycomb element composition Ultramicro-powder 30 parts, stevioside 0.7 part, pulverizing is poured in agitator groove together and is stirred;
4. 45% ethanol water uniformly sprayed in the 3. described mixed material surface of step with sprayer and be constantly uniformly mixed, be that hand is pinched agglomerating to mixed material, one pushes away namely loose state, the consumption of described 45% ethanol water be step 1. in raw materials used total formula weight 8.3%;
5. softwood step 4. made crosses 20 order stainless (steel) wires granulations with waving comminutor, dries, with the whole grain of 16 order stainless (steel) wire, obtains dry particle;
6. get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, with sprayer, essence is uniformly sprayed in dry fine silt surface, the dolomol of the dry fine silt of spray coated essence, dry particle and 1.4 parts is mixed;
7. compressing tablet, obtains finished product after damp-prrof packing.
Embodiment 7
1. each raw material is taken in proportion
Honeycomb element composition Ultramicro-powder 60 parts, filler compound sugar 35.7 parts, sweetener Aspartame 1.5 parts, acid citric acid 1.5 parts, 0.35 part, red bean essence, dolomol 0.95 part;
2. for subsequent use by crossing 80 mesh sieves after 35.7 portions of compound sugar, 1.2 parts of citric acid pulverizers pulverizing;
In 3. above-mentioned raw materials being filled a prescription: the compound sugar 35.7 parts after honeycomb element composition Ultramicro-powder 60 parts, Aspartame 1.5 parts, pulverizing, citric acid 1.2 parts are poured in agitator groove together and are stirred;
4. 50% ethanol water uniformly sprayed in the 3. described mixed material surface of step with sprayer and be constantly uniformly mixed, be that hand is pinched agglomerating to mixed material, one pushes away namely loose state, the consumption of described 50% ethanol water be step 1. in raw materials used total formula weight 11.85%;
5. softwood step 4. made crosses 20 order stainless (steel) wires granulations with waving comminutor, dries, with the whole grain of 16 order stainless (steel) wire, obtains dry particle;
6. get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, with sprayer, essence is uniformly sprayed in dry fine silt surface, the dolomol of the dry fine silt of spray coated essence, dry particle and 0.95 part is mixed;
7. compressing tablet, obtains finished product after damp-prrof packing.
Embodiment 8
1. each raw material is taken in proportion
Honeycomb element composition Ultramicro-powder 65 parts, 31.3 parts, filler sweet mellow wine, sweet 0.5 part of sweetener knob, 0.9 part, the mixture of one or both any ratios in acid citric acid or malic acid, flavoring pineapple essence 0.3 part, dolomol 2 parts;
2. after 31.3 portions of sweet mellow wine, 0.9 part of acid pulverizer being pulverized, 80 mesh sieves are for subsequent use;
In 3. above-mentioned raw materials being filled a prescription: 31.3 parts, sweet mellow wine after sweet 0.5 part of honeycomb element composition Ultramicro-powder 65 parts, knob, pulverizing, acid 0.9 part are poured in agitator groove together and are stirred;
4. 55% ethanol water uniformly sprayed in the 3. described mixed material surface of step with sprayer and be constantly uniformly mixed, be that hand is pinched agglomerating to mixed material, one pushes away namely loose state, the consumption of described 55% ethanol water be step 1. in raw materials used total formula weight 10.3%;
5. softwood step 4. made crosses 20 order stainless (steel) wires granulations with waving comminutor, dries, with the whole grain of 16 order stainless (steel) wire, obtains dry particle;
6. get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, with sprayer, essence is uniformly sprayed in dry fine silt surface, the dolomol of the dry fine silt of spray coated essence, dry particle and 2 parts is mixed;
7. compressing tablet, obtains finished product after damp-prrof packing.
Embodiment 9
The buccal tablet using embodiment 1 to prepare has carried out the test of pesticide effectiveness, and its effect is as shown in table 1-table 4.Buccal tablet prepared by other embodiment also can reach following effect, does not elaborate at this.
(1) rhinitis chronic
1, diagnostic criteria
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease Standardization of diagnosis and curative effect ", the dialectical standard of establishment rhinitis chronic is as follows:
1) to continue nasal obstruction for a long time, or intermittent, alternately have a stuffy nose, nasal mucus amount mostly is cardinal symptom.Or with diseases such as inaccessible senses in giddy, decrease of memory, insomnia, tinnitus, ear;
2) course of disease is longer, exacerbation of symptoms after tired, sense is cold.Easy concurrent ear is swollen, ear closes;
3) nasal cavity checks mucous hyperemia, and take on a red color or kermesinus, schneiderian membrane swelling is based on concha nasalis inferior.
2, treatment grouping
1) treatment group patient man 66 example, female 54 example, 31 ~ 55 years old age; 35.2 years old mean age; The course of disease 1 ~ 8 year, average course of disease 2.5 years; For reagent thing: the honeycomb essence buccal tablet prepared by the embodiment of the present invention 1; Usage and consumption: oral containing changing, one time 2 (1.2 grams/piece), every day 5 times 14 days is a course for the treatment of, treats 2 courses for the treatment of.
2) control group patient man 54 example, female 45 example, 30 ~ 58 years old age; 36.1 years old mean age; The course of disease 1 ~ 6 year, average course of disease 2.1 years; Control drug: honeycomb essence cream (self-control honeycomb element (honeycomb alcohol extract B the present invention obtained and honeycomb water extract C mixes and obtain self-control honeycomb element)+59% honey of 41%, lower same); Usage and consumption: be watered and drink, one time 15 ~ 20 grams, every day 5 times 14 days is a course for the treatment of, treats 2 courses for the treatment of.
3) two groups of patients comparing difference in the physical data such as sex, age, the course of disease and tissue typing has statistical significance (P > 0.05).
3, curative effect judging standard
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease Standardization of diagnosis and curative effect ", curative effect determinate standard is as follows:
1) cure: the transference cures such as nasal obstruction, runny nose, nasal cavity inspection is normal;
2) effective: the symptoms such as nasal obstruction, runny nose alleviate, local sign is obviously improved;
3) do not heal: sings and symptoms is not improved.
4, comparitive study
Treatment group is totally 120 examples, cures 84 examples, effective 31 examples, invalid 5 examples, total effective rate 95.8%.Control group is totally 99 examples, cures 22 examples, effective 35 examples, invalid 42 examples, total effective rate 57.6%.Two groups of comparitive study, treatment group total effective rate is obviously better than control group, and difference has significant (* P < 0.01).
Table 1 pair rhinitis chronic comparitive study (n, %)
| Group | n | Cure | Effectively | Invalid | Total effective rate |
| Treatment group | 120 | 84（70） | 31（25.8） | 5（4.2） | 95.8* |
| Control group | 99 | 22（22.2） | 35（35.4） | 42（42.4） | 57.6 |
Note: compare * P < 0.01 with control group
(2) nasosinusitis
1, diagnostic criteria
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease Standardization of diagnosis and curative effect ", the dialectical standard of establishment nasosinusitis is as follows:
1) with a large amount of viscosity or purulence nasal mucus, nasal obstruction, headache or giddy are cardinal symptom.Acute nasosinusitis occurs together heat and general malaise;
2) rapidly, the course of disease is shorter in acute nasosinusitis morbidity.If treatment is not thorough, then delay is chronic nasosinusitis, and the course of disease is longer;
3) nasal cavity checks mucous hyperemia, swelling, and nasal cavity or choana have more viscosity or purulent secretion;
4) x-ray nasal sinus takes the photograph sheet positive performance.During acute attack, blood leukocytes sum and neutrophil leucocyte increase.
2, treatment grouping
1) treatment group patient man 27 example, female 23 example, 12 ~ 68 years old age; 40.3 years old mean age; The course of disease 8 months ~ 10 years, average course of disease 4.6 years; For reagent thing: the honeycomb essence buccal tablet prepared by the embodiment of the present invention 1; Usage and consumption: oral containing changing, one time 2 (1.2 grams/piece), every day 5 times one month is a course for the treatment of, treats 3 courses for the treatment of.
2) control group patient man 29 example, female 21 example, 13 ~ 65 years old age; 38.5 years old mean age; The course of disease 5 months ~ 8 years, average course of disease 3.9 years; Control drug: honeycomb essence cream; Usage and consumption: be watered and drink, one time 15 ~ 20 grams, every day 5 times, a month sky is a course for the treatment of, treats 3 courses for the treatment of.
3) two groups of patients comparing difference in the physical data such as sex, age, the course of disease and tissue typing has statistical significance (P > 0.05).
3, curative effect judging standard
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease Standardization of diagnosis and curative effect ", curative effect determinate standard is as follows:
1) cure: transference cure, x-ray nasal sinus sheet is without exception;
2) effective: symptom is obviously improved, nasal cavity inspection is shown in that the performance such as hyperemia, mucous membrane swelling alleviates.X-ray nasal sinus takes the photograph sheet to be had and obviously changes the longevity;
3) do not heal: sings and symptoms is not improved.
4, comparitive study
Treatment group is totally 50 examples, cures 22 examples, effective 18 examples, invalid 5 examples, total effective rate 92.4%.Control group is totally 50 examples, cures 14 examples, effective 16 examples, invalid 10 examples, total effective rate 63.4%.Two groups of comparitive study, treatment group total effective rate is apparently higher than control group, and difference has significant (P < 0.05).
Table 2 pair nasosinusitis comparitive study (n, %)
| Group | n | Cure | Effectively | Invalid | Total effective rate |
| Treatment group | 50 | 22（44） | 18（36） | 5（10） | 80 |
| Control group | 50 | 14（28） | 16（32） | 10（20） | 60 |
Note: compare P < 0.05 with control group
(3) allergic rhinitis
1, diagnostic criteria
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease Standardization of diagnosis and curative effect ", the dialectical standard of establishment allergic rhinitis is as follows:
1) with paroxysmal rhiocnesmus, continuous sneeze, nasal obstruction, the clear rare amount of nasal mucus mostly is cardinal symptom, with anodimia, the disease such as eye is itched, throat is itched;
2) onset is rapid, and the general last for several minutes of symptom is to several tens minutes, and the intermittent phase, can the disease such as concurrent nettle rash, asthma without sneeze and nasal obstruction;
3) often fall ill because of sensitizers such as contact pollen, flue dust, chemical gas, variation of ambient temperature also can be brought out sometimes;
4) nasal cavity checks that mucous membrane mostly is pale, and minority is congested, and concha swelling, has more clear rare secretion during outbreak.
2, treatment grouping
1) treatment group patient man 55 example, female 37 example, 11 ~ 62 years old age; 39.3 years old mean age; The course of disease 8 months ~ 8 years, average course of disease 3.7 years; For reagent thing: the honeycomb essence buccal tablet prepared by the embodiment of the present invention 1; Usage and consumption: oral containing changing, one time 2 (1.2 grams/piece), every day 3 times 5 days is a course for the treatment of, treats 3 courses for the treatment of.
2) control group patient man 42 example, female 32 example, 10 ~ 65 years old age; 38.1 years old mean age; The course of disease 7 months ~ 10 years, average course of disease 3.5 years; Control drug: honeycomb essence cream; Usage and consumption: be watered and drink, one time 15 ~ 20 grams, every day 3 times 5 days is a course for the treatment of, treats 3 courses for the treatment of.
3) two groups of patients comparing difference in the physical data such as sex, age, the course of disease and tissue typing has statistical significance (P > 0.05).
3, curative effect judging standard
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease Standardization of diagnosis and curative effect ", curative effect determinate standard is as follows:
1) cure: symptom, sign disappear, more than 3 months without recurrence;
2) effective: during outbreak, symptom, sign alleviate, attack times reduces;
3) do not heal: symptom and sign are not improved.
4, comparitive study
Treatment group is totally 92 examples, cures 48 examples, effective 37 examples, invalid 7 examples, total effective rate 92.4%.Control group is totally 74 examples, cures 22 examples, effective 25 examples, invalid 27 examples, total effective rate 63.4%.Two groups of comparitive study, treatment group total effective rate is apparently higher than control group, and difference has significant (P < 0.05).
Table 3 pair allergic rhinitis comparitive study (n, %)
| Group | n | Cure | Effectively | Invalid | Total effective rate |
| Treatment group | 92 | 48（52.2） | 37（40.2） | 7（7.6） | 92.4 |
| Control group | 74 | 22（29.7） | 25（33.8） | 27（36.5） | 63.5 |
Note: compare P < 0.05 with control group
(4) chronic pharyngitis
1, diagnostic criteria
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease Standardization of diagnosis and curative effect ", the dialectical standard of establishment chronic pharyngitis is as follows:
1) with pharyngeal drying, or itch, ache, foreign body sensation, swelling sense etc. is cardinal symptom;
2) course of disease is longer, heavy time light during pharyngeal malaise symptoms;
3) acute throat obstruction history of repeated attack is often had, or the long-term mouth breathing because of chronic rhinitis, or prisoner's tobacco and wine are excessive, and surrounding air drying, the different gas stimulation of dust etc. cause morbidity;
4) pharyngeal inspection mucous membrane swelling, or have atrophy, or have kermesinus patch shape, dendroid congested.Lateral pharyngeal band enlargement, pharynx rear wall lymph foilicie hyperplasia.
2, treatment grouping
1) treatment group patient man 38 example, female 22 example, 20 ~ 60 years old age; 35.7 years old mean age; The course of disease 3 months ~ 2 years, average course of disease 11 months; For reagent thing: the honeycomb essence buccal tablet prepared by the embodiment of the present invention 1; Usage and consumption: oral containing changing, one time 2 (1.2 grams/piece), every day 3 ~ 4 times 7 days months is a course for the treatment of, treats 3 courses for the treatment of.
2) control group patient man 36 example, female 24 example, 20 ~ 58 years old age; 34.2 years old mean age; The course of disease 5 months ~ 2 years, average course of disease 1.0 years; Control drug: honeycomb essence cream; Usage and consumption: be watered and drink, one time 15 ~ 20 grams, every day 3 ~ 4 times 7 days is a course for the treatment of, treats 3 courses for the treatment of.
3) two groups of patients comparing difference in the physical data such as sex, age, the course of disease and tissue typing has statistical significance (P > 0.05).
3, curative effect judging standard
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease Standardization of diagnosis and curative effect ", curative effect determinate standard is as follows:
1) cure: pharyngeal transference cure, check normal;
2) effective: pharyngeal sings and symptoms obviously alleviates;
3) do not heal: sings and symptoms is without significant change.
4, comparitive study
Treatment group is totally 60 examples, cures 36 examples, effective 20 examples, invalid 4 examples, total effective rate 93.3%.Control group is totally 60 examples, cures 20 examples, effective 22 examples, invalid 18 examples, total effective rate 70.0%.Two groups of comparitive study, treatment group total effective rate is apparently higher than control group, and difference has significant (P < 0.05).
Table 4 pair chronic pharyngitis comparitive study (n, %)
| Group | n | Cure | Effectively | Invalid | Total effective rate |
| Treatment group | 60 | 36（60） | 20（33.3） | 4（6.7） | 93.3 |
| Control group | 60 | 20（33.3） | 22（36.7） | 18（30） | 70 |
Note: compare P < 0.05 with control group
Comprehensive above result of the test, shows that the honeycomb essence buccal tablet prepared by the present invention all has significant clinical efficacy to rhinitis chronic, nasosinusitis, allergic rhinitis and chronic pharyngitis.
Obviously, the above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here cannot give exhaustive to all embodiments.Every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.
Claims (7)
1. a honeycomb essence buccal tablet, it is characterized in that: this honeycomb essence buccal tablet is made up of the raw material of following weight parts: honeycomb element composition Ultramicro-powder 20 ~ 80 parts, filler 15 ~ 78 parts, sweetener 0.02 ~ 1.5 part, acid 0.2 ~ 2 part, flavoring essence 0.05 ~ 0.5 part, lubricant 0.8 ~ 2 part;
Wherein, described honeycomb element composition Ultramicro-powder is the Ultramicro-powder of the mixture of honeycomb element freeze-dried powder and yam flour, and its fineness is 3000 ~ 3500 orders, and granularity is 5 ~ 4.5 μm, and the mass ratio of described honeycomb element freeze-dried powder and yam flour is 1:0.2 ~ 0.5;
Described honeycomb element freeze-dried powder is prepared by following method:
(1) honeycomb alcohol extract B is extracted: after honeycomb is freezing under-15 DEG C ~-18 DEG C conditions, extractor is dropped into after being ground into meal, add the edible alcohol of its volume 3 ~ 4 times, 10 DEG C ~ 25 DEG C are soaked and stir 72 ~ 96 hours with the rotating speed of 10 ~ 12 revs/min, through 60 ~ 80 order plate-frame filterings, obtain filter residue A, filtrate is 0.085 ~ 0.09MPa in vacuum, temperature is under the condition of 45 DEG C ~ 55 DEG C, obtains honeycomb alcohol extract B after Vacuum Concentration;
(2) honeycomb water extract C is extracted: filter residue A is dropped into extractor, and add the pure water of its quality 6 ~ 7 times, 80 DEG C ~ 85 DEG C are soaked and stir 6 ~ 7 hours with the rotating speed of 10 ~ 12 revs/min, through 60 ~ 80 order plate-frame filterings, remove filter residue, filtrate is 0.085 ~ 0.09MPa in vacuum, and temperature is under the condition of 65 DEG C ~ 70 DEG C, obtains honeycomb water extract C after Vacuum Concentration;
(3) honeycomb element freeze-dried powder is prepared: mixed and obtain honeycomb element by honeycomb alcohol extract B and honeycomb water extract C, this honeycomb element is put into vacuum freeze, first precooling, temperature is-2 DEG C ~-10 DEG C, time is 1 ~ 1.5 hour, sharp freezing again, temperature is-10 DEG C ~-45 DEG C, and the time is 0.5 ~ 4 hour, then vacuumize and heat, vacuum is 40 ~ 0.05 millimetress of mercury, and heating-up temperature is 15 ~ 20 DEG C, obtains honeycomb element freeze-dried powder;
Described filler is the mixture of one or more in sucrose, starch, dextrin, corn dextrin, improvement dextrin, glucose, lactose, maltitol, sorbierite, xylitol, sweet mellow wine, compound sugar, hydroxyl isomaltulose or trehalose;
Described sweetener is that Aspartame, knob are sweet, the mixture of one or more in Sucralose, stevioside or glycyrrhizin;
Described acid is the mixture of one or more in citric acid, tartaric acid, malic acid or lactic acid;
Described lubricant is dolomol.
2. a preparation technology for honeycomb essence buccal tablet as claimed in claim 1, is characterized in that: this technique comprises the steps:
(1) prefabricated honeycomb element composition Ultramicro-powder;
(2) 80 mesh sieves are crossed after filler, acid pulverizer being pulverized for subsequent use;
(3) honeycomb element composition Ultramicro-powder, sweetener and the filler after pulverizing, acid are poured in agitator groove together and stirred;
(4) ethanol water uniformly sprayed the mixed material surface described in step (3) with sprayer, and constantly stir and make it to mix, obtain softwood;
(5) softwood made being crossed 20 order stainless (steel) wires granulations with waving comminutor, drying, with the whole grain of 16 order stainless (steel) wire, obtaining dry particle;
(6) get dry particle and cross the dry fine silt that 30 order stainless (steel) wires sift out, flavoring essence is uniformly sprayed in dry fine silt surface, by even to the dry fine silt of spray coated flavoring essence, dry particle and mix lubricant with sprayer;
(7) compressing tablet, obtains finished product after damp-prrof packing;
Wherein, the method for described prefabricated honeycomb element composition Ultramicro-powder is:
(1) honeycomb alcohol extract B is extracted: after honeycomb is freezing under-15 DEG C ~-18 DEG C conditions, extractor is dropped into after being ground into meal, add the edible alcohol of its volume 3 ~ 4 times, 10 DEG C ~ 25 DEG C are soaked and stir 72 ~ 96 hours with the rotating speed of 10 ~ 12 revs/min, through 60 ~ 80 order plate-frame filterings, obtain filter residue A, filtrate is 0.085 ~ 0.09MPa in vacuum, temperature is under the condition of 45 DEG C ~ 55 DEG C, obtains honeycomb alcohol extract B after Vacuum Concentration;
(2) honeycomb water extract C is extracted: filter residue A is dropped into extractor, and add the pure water of its quality 6 ~ 7 times, 80 DEG C ~ 85 DEG C are soaked and stir 6 ~ 7 hours with the rotating speed of 10 ~ 12 revs/min, through 60 ~ 80 order plate-frame filterings, remove filter residue, filtrate is 0.085 ~ 0.09MPa in vacuum, and temperature is under the condition of 65 DEG C ~ 70 DEG C, obtains honeycomb water extract C after Vacuum Concentration;
(3) honeycomb element freeze-dried powder is prepared: mixed and obtain honeycomb element by honeycomb alcohol extract B and honeycomb water extract C, this honeycomb element is put into vacuum freeze, first precooling, temperature is-2 DEG C ~-10 DEG C, time is 1 ~ 1.5 hour, sharp freezing again, temperature is-10 DEG C ~-45 DEG C, and the time is 0.5 ~ 4 hour, then vacuumize and heat, vacuum is 40 ~ 0.05 millimetress of mercury, and heating-up temperature is 15 DEG C ~ 20 DEG C, obtains honeycomb element freeze-dried powder;
(4) honeycomb element composition Ultramicro-powder is prepared: be that 1:0.2 ~ 0.5 is placed in trough type mixing machine by honeycomb element freeze-dried powder and yam flour according to mass ratio, mix 20 ~ 30 minutes, Universalpulverizer is used to pulverize once in this mixture, again the mixture after above-mentioned pulverizing is placed in micronizer to pulverize, compressed air pressure is adjusted to 10MPa, obtains the honeycomb element composition Ultramicro-powder of fineness 3000 ~ 3500 order, granularity 5 ~ 4.5 μm.
3. preparation technology according to claim 2, is characterized in that: in described step (4), the concentration of ethanol water is 30% ~ 60%, and the consumption of ethanol water is 5.5% ~ 12% of honeycomb essence buccal tablet composition of raw materials gross weight.
4. preparation technology according to claim 2, is characterized in that: described filler is the mixture of one or more in sucrose, starch, dextrin, corn dextrin, improvement dextrin, glucose, lactose, maltitol, sorbierite, xylitol, sweet mellow wine, compound sugar, hydroxyl isomaltulose or trehalose.
5. preparation technology according to claim 2, is characterized in that: described sweetener is that Aspartame, knob are sweet, the mixture of one or more in Sucralose, stevioside or glycyrrhizin.
6. preparation technology according to claim 2, is characterized in that: described acid is the mixture of one or more in citric acid, tartaric acid, malic acid or lactic acid.
7. preparation technology according to claim 2, is characterized in that: described lubricant is dolomol.
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