CN103230012A - Honeycomb essence buccal tablet and preparation process thereof - Google Patents
Honeycomb essence buccal tablet and preparation process thereof Download PDFInfo
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- CN103230012A CN103230012A CN2013101672730A CN201310167273A CN103230012A CN 103230012 A CN103230012 A CN 103230012A CN 2013101672730 A CN2013101672730 A CN 2013101672730A CN 201310167273 A CN201310167273 A CN 201310167273A CN 103230012 A CN103230012 A CN 103230012A
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Abstract
The invention discloses a honeycomb essence buccal tablet and a preparation process thereof, belonging to the technical field of honeycomb preparation. The honeycomb essence buccal tablet disclosed by the invention is prepared from ultra-fine powder of a honeycomb essence composition, a filling agent, a sweetening agent, an acidulant, edible essence and a lubricating agent. The invention further provides the preparation process of the honeycomb essence buccal tablet. The honeycomb essence buccal tablet disclosed by the invention has the characteristics of being easy for taking, good in mouth feel and rapid in absorption and is capable of overcoming the disadvantages of being insufficient in honeycomb mouth feel and lower in absorption utilization rate, and obviously increasing the absorption utilization rates of effective components in the honeycomb essence; and the honeycomb essence buccal tablet has important value and contribution for clinical treatment, health care and prevention of nasopharyngitis.
Description
Technical field
The invention belongs to honeycomb preparation technique field, more specifically relate to the plain buccal tablet of a kind of honeycomb and preparation technology thereof.
Background technology
Honeycomb is that honeybee breeds the place that the offspring stocks grain, is keeping multiple particular matters such as the propolis of honeybee husks (similar animal placenta), natural antiinflammation, the royal jelly that contains the rare anticancer Fungicidal substance 10-hydroxyl caproleic acid of occurring in nature (being commonly called as royal jelly acid), the melissa powder that the title of " nutrition library that concentrates " is arranged, beeswax in the honeycomb.The composition of honeycomb is very complicated, and main component comprises: aliphatic acid, tannin, glucoside, protein, amino acid, taurine, enzyme, trace element and the not bright material of many compositions.The modern medicine scientific research is found, honeycomb has good result for treatment rhinitis chronic, nasosinusitis, nose sensitivity, allergic rhinitis and chronic pharyngitis etc., can alleviate the symptoms such as throat discomfort, nasal obstruction, runny nose, headache and dizziness because all kinds of nasopharyngitises cause rapidly.
Before bimillennium, the effect that just has recognized that honeycomb among the people, people are by direct chewing honeycomb, and pharynx juice scum method utilizes honeycomb to treat nasopharyngitis.But pharynx juice scum method makes that a lot of active ingredients in the honeycomb can't be absorbed by human body, causes bigger waste; Simultaneously, because the mouthfeel bitterness of honeycomb, and hygienic issues such as residual honeybee children pupa is arranged also sometimes in the honeycomb, the masses that limited honeycomb to a great extent promote.
For addressing the above problem, in conjunction with modern food processing technology, people are refined into the honeycomb element with the extracts active ingredients in the honeycomb, and then develop products such as beehive tea, honeycomb are happy, the plain cream of honeycomb, honeycomb powder capsule.But no matter be that beehive tea, honeycomb are happy, the plain cream of honeycomb or honeycomb powder capsule, the eating method of these products all is to drink or swallow by converting water, effectively being divided into by after the absorption of organs such as human intestines and stomach and liver of honeycomb element, arrive the nasopharynx pathological tissues through body-internal-circulation, absorption rate is lower, can't well bring into play product to the effect of nasopharynx treatment.
The honeycomb element is made buccal tablet both be conducive to improve the bad mouthfeel of honeycomb, be conducive to the plain long duration of action of honeycomb again in the pathological tissues of nasal cavity or throat, give full play to the honeycomb element for the therapeutic efficiency of nasopharyngitis, solve above drawback.
Have not yet to see the report of the plain buccal tablet preparation of honeycomb.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of good mouthfeel, is easy to absorption, instant, the plain buccal tablet of the significant honeycomb of effect, and this buccal tablet can overcome deficiency and the lower drawback of absorption rate on the honeycomb mouthfeel.
The present invention also provides the preparation technology of the plain buccal tablet of a kind of honeycomb.
For solving the problems of the technologies described above, the technical scheme that the present invention takes is:
The plain buccal tablet of a kind of honeycomb, the plain buccal tablet of this honeycomb is to be made by the raw material of following weight parts: 20～80 parts in honeycomb promotor composition ultra micro powder, 15～78 parts of fillers, 0.02～1.5 part of sweetener, 0.2～2 part of acid, 0.05～0.5 part of flavoring essence, 0.8～2 part of lubricant;
Wherein, described honeycomb promotor composition ultra micro powder is the ultra micro powder of being made by the mixture of the plain freeze-dried powder of honeycomb and yam flour, and its fineness is 3000～3500 orders, and granularity is 5～4.5 μ m.
Further, the plain freeze-dried powder of described honeycomb is 1:0.2～0.5 with the preferred mass ratio of yam flour.
The plain freeze-dried powder of the honeycomb that the present invention uses can be by buying honeycomb according to after disclosed method has prepared honeycomb element (being the honeycomb extract) in the prior art, and recycling freeze drying process of the prior art prepares freeze-dried powder.In order to reach better product effect, the present invention provides the preparation method of a kind of honeycomb element and freeze-dried powder thereof at this:
(1) extract honeycomb alcohol extract B: with honeycomb after freezing under-15 ℃～-18 ℃ conditions, drop into extractor after being ground into meal, the edible alcohol that adds 3～4 times of its volumes, 10 ℃～25 ℃ are soaked and stirred 72～96 hours with 10～12 rev/mins rotating speed, filter through 60～80 keevil frames, get filter residue A, filtrate is 0.085～0.09MPa in vacuum, temperature is under 45 ℃～55 ℃ the condition, after vacuum concentrates honeycomb alcohol extract B;
(2) extract honeycomb water extract C: filter residue A is dropped into extractor, and add the pure water of 6～7 times of its quality, 80 ℃～85 ℃ are soaked and stirred 6～7 hours with 10～12 rev/mins rotating speed, filter through 60～80 keevil frames, remove filter residue, filtrate is 0.085～0.09MPa in vacuum, and temperature is under 65 ℃～70 ℃ the condition, after vacuum concentrates honeycomb water extract C;
(3) the plain freeze-dried powder of preparation honeycomb: honeycomb alcohol extract B and honeycomb water extract C mixed namely get the honeycomb element, this honeycomb element is put into vacuum freeze, first precooling, temperature is-2 ℃～-10 ℃, time is 1～1.5 hour, sharp freezing again, temperature are-10 ℃～-45 ℃, and the time is 0.5～4 hour, vacuumize then and heat, vacuum is 40～0.05 millimetress of mercury, and heating-up temperature is 15～20 ℃, gets the plain freeze-dried powder of honeycomb.
Further, in the plain buccal tablet of above-mentioned honeycomb, described filler is one or more the mixture in sucrose, starch, dextrin, corn dextrin, improvement dextrin, glucose, lactose, maltitol, sorbierite, xylitol, sweet mellow wine, compound sugar, hydroxyl isomaltulose or the trehalose;
Described sweetener is that Aspartame, knob are sweet, one or more the mixture in Sucralose, stevioside or the glycyrrhizin;
Described acid is one or more the mixture in citric acid, tartaric acid, malic acid or the lactic acid;
Described lubricant is dolomol; And according to the needs of different taste, add the flavoring essence of all kinds of tastes.
The plain buccal tablet of honeycomb of the present invention can adopt the buccal tablet preparation technology of routine of the prior art to process, and in order to obtain better product effect, the present invention also provides a kind of preferable preparation technique at this, and this technology comprises the steps:
(1) prefabricated honeycomb promotor composition ultra micro powder;
(2) afterwards 80 mesh sieves are standby excessively with the pulverizer pulverizing with above-mentioned filler, acid;
(3) filler, acid after honeycomb promotor composition ultra micro powder, sweetener and the pulverizing are poured in the agitator groove together and stirred;
(4) with sprayer ethanol water is uniformly sprayed on the described mixed material of step (3) surface, and constantly stirring makes it to mix, obtain softwood;
(5) softwood of making is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
(6) get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer flavoring essence is uniformly sprayed in dried fine silt surface, dried fine silt, dried particle and the lubricant (being preferably dolomol) that sprayed edible essence mixed;
(7) compressing tablet gets finished product behind the damp-prrof packing.
Further, the concentration of ethanol water is preferably 30%～60% in the described step (4), and the consumption of ethanol water is preferably 5.5%～12% of the plain buccal tablet composition of raw materials of honeycomb gross weight.
In the step (1), the method for described prefabricated honeycomb promotor composition ultra micro powder is specially:
(1) extract honeycomb alcohol extract B: with honeycomb after freezing under-15 ℃～-18 ℃ conditions, drop into extractor after being ground into meal, the edible alcohol that adds 3～4 times of its volumes, 10 ℃～25 ℃ are soaked and stirred 72～96 hours with 10～12 rev/mins rotating speed, filter through 60～80 keevil frames, get filter residue A, filtrate is 0.085～0.09MPa in vacuum, temperature is under 45 ℃～55 ℃ the condition, after vacuum concentrates honeycomb alcohol extract B;
(2) extract honeycomb water extract C: filter residue A is dropped into extractor, and add the pure water of 6～7 times of its quality, 80 ℃～85 ℃ are soaked and stirred 6～7 hours with 10～12 rev/mins rotating speed, filter through 60～80 keevil frames, remove filter residue, filtrate is 0.085～0.09MPa in vacuum, and temperature is under 65 ℃～70 ℃ the condition, after vacuum concentrates honeycomb water extract C;
(3) the plain freeze-dried powder of preparation honeycomb: honeycomb alcohol extract B and honeycomb water extract C mixed namely get the honeycomb element, this honeycomb element is put into vacuum freeze, first precooling, temperature is-2 ℃～-10 ℃, time is 1～1.5 hour, sharp freezing again, temperature are-10 ℃～-45 ℃, and the time is 0.5～4 hour, vacuumize then and heat, vacuum is 40～0.05 millimetress of mercury, and heating-up temperature is 15 ℃～20 ℃, gets the plain freeze-dried powder of honeycomb;
(4) preparation honeycomb promotor composition ultra micro powder: be that 1:0.2 places trough type mixing machine according to mass ratio with the plain freeze-dried powder of honeycomb and yam flour, mixed 20～30 minutes, use Universalpulverizer to pulverize once in this mixture, again the mixture after the above-mentioned pulverizing is placed micronizer to pulverize, compressed air pressure is adjusted into 10MPa, obtains the honeycomb promotor composition ultra micro powder of fineness 3000～3500 orders, granularity 5～4.5 μ m.
Beneficial effect of the present invention is:
(1) the present invention has added the ultramicro grinding that yam flour is conducive to the honeycomb element when preparation honeycomb promotor composition ultra micro powder: because the existence of honeycomb alcohol extract in the plain freeze-dried powder of honeycomb, when using micronizer to pulverize, difficult feed, crush efficiency is low, and it is still bigger to pulverize the back particle, and its fineness is about 300 orders; The plain freeze-dried powder of yam flour and honeycomb is fully pulverized, mixed; wherein be unfavorable for grease and the stickum pulverized with abundant absorption; make it go for air-flowing type ultramicro grinding technology and obtain honeycomb promotor composition ultra micro powder, used stable process conditions is fit to large-scale industrial production.
(2) the present invention can improve the honeycomb element effectively to the therapeutic efficiency of nasopharyngitis: the eating method of the plain product of traditional honeycomb is generally and contains clothes, converts that water is taken or water distribution is swallowed, after the active ingredient of honeycomb element is mainly absorbed by small intestine, enter the circulation of body inner blood through capillary and be transported to whole body, then remake the pathological tissues for nasal cavity, throat, utilization rate is lower, can't fully play the honeycomb element to the therapeutic efficiency of nasopharyngitis.And the honeycomb element is prepared into buccal tablet, because containing slowly, the plain oral cavity that can rest on the long period of honeycomb continues the performance drug effect, and because the fineness of honeycomb element reaches 3000～3500 orders, make the active ingredient of honeycomb element directly to be absorbed by pathological tissues, the loss that has produced when having avoided active ingredient to absorb by organs such as human intestines and stomach has effectively improved honeycomb and has have the absorption rate of imitating composition.Therefore, the plain buccal tablet of honeycomb of the present invention has important value and contribution at nasopharyngitis clinical treatment and health care prevention.
(3) the present invention is conducive to enlarge the audient crowd of the plain product of honeycomb: because the plain mouthfeel bitterness of honeycomb, be not suitable for directly taking, on the market the plain product of common honeycomb be with honeycomb plain with make honeycomb element cream after honey, melissa powder, royal jelly, propolis allotment mix; The plain cream of honeycomb is because honey content is higher, and the diabetic group does not use.This product adds sweetener, acid, flavoring essence etc. and on mouthfeel the honeycomb element has been carried out seasoning, makes the honeycomb element tasty, unique flavor; Simultaneously if when selecting wherein one or more of maltitol, sorbierite, xylitol, sweet mellow wine, hydroxyl isomaltulose for filler in prescription, product then can be used as sugarfree foods and uses for the diabetes patient, thereby enlarges the audient crowd of honeycomb element product.
(4) product of the present invention does not exist the synthetic drug treatment to the injury of body, and good repair can be arranged histocyte in damaged condition: the honeycomb element is the pollution-free food of pure natural, and the materials such as propolis in the honeycomb element have the effect that suppresses and kill to bacterium, fungi, virus; Royal jelly, pollen compound nutritional composition in the honeycomb element can fully promote immune function of human body to improve, and make nasopharyngitis patient remission and disappearance.
The specific embodiment
According to the parts by weight meter, the plain buccal tablet of honeycomb is prepared by following raw materials according: 20～80 parts in honeycomb promotor composition ultra micro powder, 15～78 parts of fillers, 0.02～1.5 part of sweetener, 0.2～2 part of acid, 0.05～0.5 part of flavoring essence, 0.8～2 part of lubricant; Wherein, described honeycomb promotor composition ultra micro powder is the ultra micro powder of being made by the mixture of the plain freeze-dried powder of honeycomb and yam flour, and its fineness is 3000～3500 orders, and granularity is 5～4.5 μ m.The plain freeze-dried powder of described honeycomb is 1:0.2～0.5 with the preferred mass ratio of yam flour.
Filler can be one or more mixture of sucrose, starch, dextrin, corn dextrin, improvement dextrin, glucose, lactose, maltitol, sorbierite, xylitol, sweet mellow wine, compound sugar, hydroxyl isomaltulose or trehalose;
Sweetener can be that Aspartame, knob are sweet, one or more the mixture in Sucralose, stevioside or the glycyrrhizin;
Acid can be one or more the mixture in citric acid, tartaric acid, malic acid or the lactic acid;
Lubricant is dolomol.
According to described raw material proportioning, preparation technology comprises:
1. prefabricated honeycomb promotor composition ultra micro powder;
2. it is standby to cross 80 mesh sieves after filler, acid being pulverized with pulverizer;
3. filler, acid after honeycomb promotor composition ultra micro powder, sweetener and the pulverizing are poured in the agitator groove together and stirred;
4. with sprayer ethanol water is uniformly sprayed on 3. described mixed material surface of step, and constantly stir and make it to mix, obtain softwood;
5. the softwood of making is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
6. get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer flavoring essence is uniformly sprayed in dried fine silt surface, dried fine silt, dried particle and the mix lubricant that sprayed edible essence is even;
7. compressing tablet gets finished product behind the damp-prrof packing.
More than the plain buccal tablet of the honeycomb of preparation can add the plain buccal tablet of honeycomb that all kinds of flavoring essences are produced different taste.
The concrete grammar of prefabricated honeycomb promotor composition ultra micro powder comprises:
1. extract honeycomb alcohol extract B: with honeycomb after freezing under-15 ℃～-18 ℃ conditions, drop into extractor after being ground into meal, the edible alcohol that adds 3～4 times of its volumes, 10 ℃～25 ℃ are soaked and stirred 72～96 hours with 10～12 rev/mins rotating speed, filter through 60～80 keevil frames, get filter residue A, filtrate is 0.085～0.09MPa in vacuum, temperature is under 45～55 ℃ the condition, after vacuum concentrates honeycomb alcohol extract B;
2. extract honeycomb water extract C: filter residue A is dropped into extractor, and add the pure water of 6～7 times of its quality, 80～85 ℃ are soaked and stirred 6～7 hours with 10～12 rev/mins rotating speed, filter through 60～80 keevil frames, remove filter residue, filtrate is 0.085～0.09MPa in vacuum, and temperature is under 65～70 ℃ the condition, after vacuum concentrates honeycomb water extract C;
3. prepare the plain freeze-dried powder of honeycomb: honeycomb alcohol extract B and honeycomb water extract C are mixed, put into vacuum freeze after pouring the honeycomb extract that mixes into tray, first precooling, temperature is-2 ℃～-10 ℃, time is 1～1.5 hour, sharp freezing again, temperature are-10 ℃～-45 ℃, and the time is 0.5～4 hour, vacuumize then and heat, vacuum is 40～0.05 millimetress of mercury, and heating-up temperature is 15～20 ℃, gets the honeycomb extract freeze-drying powder;
4. prepare honeycomb promotor composition ultra micro powder: honeycomb extract freeze-drying powder, yam flour (mass ratio is 1:0.2) are put in the trough type mixing machine, mixed 20～30 minutes, use Universalpulverizer to pulverize once in this mixture, again the mixture after the above-mentioned pulverizing is placed micronizer to pulverize, compressed air pressure is adjusted into 10MPa, obtains the honeycomb promotor composition ultra micro powder of fineness 3000～3500 orders, granularity 5～4.5 μ m.
Below be several embodiments of the present invention, further specify the present invention, but the present invention is not limited only to this.
Embodiment 1
1. take by weighing each raw material in proportion
41 parts in honeycomb promotor composition ultra micro powder, 55 parts of filler xylitols, 1.2 parts of sweetener Aspartames, 1.5 parts of acid citric acids, 0.3 part in orange flavor essence, 1 part of dolomol;
2. it is standby to cross 80 mesh sieves after 55 parts of xylitols, 1.5 parts of citric acids being pulverized with pulverizer;
In 3. above-mentioned raw materials being filled a prescription: 55 parts of xylitols, citric acid after 41 parts in honeycomb promotor composition ultra micro powder, 1.2 parts of Aspartames, the pulverizing are poured in the agitator groove together for 1.5 parts and are stirred;
4. with sprayer 40% ethanol water is uniformly sprayed on 3. described mixed material surface and constantly mixing of step, being hand to mixed material pinches agglomerating, one pushes away namely the state that looses, the consumption of described 40% ethanol water be step 1. in raw materials used prescription gross weight 7.2%;
5. the softwood that 4. step is made is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, and oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
6. get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer essence is uniformly sprayed in dried fine silt surface, the dolomol that sprayed the dried fine silt of essence, dried particle and 1 part is mixed;
7. compressing tablet gets finished product behind the damp-prrof packing.
Embodiment 2
1. take by weighing each raw material in proportion
50 parts in honeycomb promotor composition ultra micro powder, 47 parts of filler glucose, sweet 0.9 part of sweetener knob, 0.6 part of acid malic acid, 0.4 part of flavoring apple essence, 1.1 parts of dolomols;
2. it is standby to cross 80 mesh sieves after 47 parts of glucose, 0.6 part of malic acid being pulverized with pulverizer;
In 3. above-mentioned raw materials being filled a prescription: 47 parts of glucose, malic acid after 50 parts in honeycomb promotor composition ultra micro powder, sweet 0.9 part of knob, the pulverizing are poured in the agitator groove together for 0.6 part and are stirred;
4. with sprayer 35% ethanol water is uniformly sprayed on 3. described mixed material surface and constantly mixing of step, being hand to mixed material pinches agglomerating, one pushes away namely the state that looses, the consumption of described 35% ethanol water be step 1. in raw materials used prescription gross weight 9.6%;
5. the softwood that 4. step is made is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, and oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
6. get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer essence is uniformly sprayed in dried fine silt surface, the dolomol that sprayed the dried fine silt of essence, dried particle and 1.1 parts is mixed;
7. compressing tablet gets finished product behind the damp-prrof packing.
Embodiment 3
1. take by weighing each raw material in proportion
70 parts in honeycomb promotor composition ultra micro powder, 28 parts of filler D-sorbites, 0.07 part of Sweetener Sucralose, 0.6 part in acid tartaric acid, 0.53 part of grape essence, 0.8 part of dolomol;
2. it is standby to cross 80 mesh sieves after 28 parts of D-sorbites, 0.6 part of tartaric acid being pulverized with pulverizer;
In 3. above-mentioned raw materials being filled a prescription: 28 parts of D-sorbites, tartaric acid after 70 parts in honeycomb promotor composition ultra micro powder, 0.07 part of Sucralose, the pulverizing are poured in the agitator groove together for 0.6 part and are stirred;
4. with sprayer 55% ethanol water is uniformly sprayed on 3. described mixed material surface and constantly mixing of step, being hand to mixed material pinches agglomerating, one pushes away namely the state that looses, the consumption of described 60% ethanol water be step 1. in raw materials used prescription gross weight 10.6%;
5. the softwood that 4. step is made is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, and oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
6. get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer essence is uniformly sprayed in dried fine silt surface, the dolomol that sprayed the dried fine silt of essence, dried particle and 0.8 part is mixed;
7. compressing tablet gets finished product behind the damp-prrof packing.
Embodiment 4
1. take by weighing each raw material in proportion
20 parts in honeycomb promotor composition ultra micro powder, 78 parts in the mixture of any ratio of one or both of filler sucrose or lactose, 0.2 part of sweetener glycyrrhizin, 0.4 part of acid lactic acid, 0.5 part of milk flavour, 0.9 part of dolomol;
2. the mixture of one or both any ratios of 78 portions of sucrose or lactose, 0.4 part of lactic acid being pulverized the back with pulverizer, to cross 80 mesh sieves standby;
In 3. above-mentioned raw materials being filled a prescription: 78 parts in mixture, the lactic acid of the sucrose after 20 parts in honeycomb promotor composition ultra micro powder, 0.2 part of glycyrrhizin, the pulverizing or one or both any ratios of lactose are poured in the agitator groove together for 0.4 part and are stirred;
4. with sprayer 30% ethanol water is uniformly sprayed on 3. described mixed material surface and constantly mixing of step, being hand to mixed material pinches agglomerating, one pushes away namely the state that looses, the consumption of described 30% ethanol water be step 1. in raw materials used prescription gross weight 12%;
5. the softwood that 4. step is made is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, and oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
6. get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer essence is uniformly sprayed in dried fine silt surface, the dolomol that sprayed the dried fine silt of essence, dried particle and 0.9 part is mixed;
7. compressing tablet gets finished product behind the damp-prrof packing.
Embodiment 5
1. take by weighing each raw material in proportion
78 parts in honeycomb promotor composition ultra micro powder, 18 parts in the mixture of one or more any ratios in filler starch, dextrin, corn dextrin, the improvement dextrin, the sweetener knob is sweet, 0.7 part in the mixture of one or both any ratios of Aspartame, 1.3 parts in the mixture of one or both any ratios of acid citric acid or malic acid, 0.4 part in peppermint essence, 0.08 part of lemon extract, 0.02 part in American Ginseng essence, 1.5 parts of dolomols;
2. it is standby to cross 80 mesh sieves after the mixture of 1.3 parts of citric acids or one or both any ratios of malic acid being pulverized with pulverizer;
3. with in the above-mentioned raw materials prescription: 78 parts in honeycomb promotor composition ultra micro powder, knob are sweet, the mixture of 18 parts in the mixture of one or more any ratios in 0.7 part in the mixture of one or both any ratios of Aspartame, starch, dextrin, corn dextrin, improvement dextrin, the citric acid after pulverizing or one or both any ratios of malic acid is poured in the agitator groove together for 1.3 parts and stirred;
4. with sprayer 60% ethanol water is uniformly sprayed on 3. described mixed material surface and constantly mixing of step, being hand to mixed material pinches agglomerating, one pushes away namely the state that looses, the consumption of described 60% ethanol water be step 1. in raw materials used prescription gross weight 5.5%;
5. the softwood that 4. step is made is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, and oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
6. get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer essence is uniformly sprayed in dried fine silt surface, the dolomol that sprayed 1.5 parts of the dried fine silts of essence, dried particle is mixed;
7. compressing tablet gets finished product behind the damp-prrof packing.
Embodiment 6
1. take by weighing each raw material in proportion
30 parts in honeycomb promotor composition ultra micro powder, 67 parts of filler trehaloses, 0.7 part of sweetener stevioside, 0.7 part in the mixture of one or both any ratios of acid citric acid or malic acid, 0.2 part of vanilla, 1.4 parts of dolomols;
2. it is standby to cross 80 mesh sieves after 67 portions of trehaloses, 0.7 portion of acid being pulverized with pulverizer;
In 3. above-mentioned raw materials being filled a prescription: the mixture of 67 parts of trehaloses, citric acid or one or both any ratios of malic acid after 30 parts in honeycomb promotor composition ultra micro powder, 0.7 part of stevioside, the pulverizing is poured in the agitator groove together for 0.7 part and is stirred;
4. with sprayer 45% ethanol water is uniformly sprayed on 3. described mixed material surface and constantly mixing of step, being hand to mixed material pinches agglomerating, one pushes away namely the state that looses, the consumption of described 45% ethanol water be step 1. in raw materials used prescription gross weight 8.3%;
5. the softwood that 4. step is made is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, and oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
6. get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer essence is uniformly sprayed in dried fine silt surface, the dolomol that sprayed the dried fine silt of essence, dried particle and 1.4 parts is mixed;
7. compressing tablet gets finished product behind the damp-prrof packing.
Embodiment 7
1. take by weighing each raw material in proportion
60 parts in honeycomb promotor composition ultra micro powder, 35.7 parts of filler compound sugar, 1.5 parts of sweetener Aspartames, 1.5 parts of acid citric acids, 0.35 part in red bean essence, 0.95 part of dolomol;
2. it is standby to cross 80 mesh sieves after 35.7 portions of compound sugar, 1.2 parts of citric acids being pulverized with pulverizer;
In 3. above-mentioned raw materials being filled a prescription: 35.7 parts of compound sugar, citric acid after 60 parts in honeycomb promotor composition ultra micro powder, 1.5 parts of Aspartames, the pulverizing are poured in the agitator groove together for 1.2 parts and are stirred;
4. with sprayer 50% ethanol water is uniformly sprayed on 3. described mixed material surface and constantly mixing of step, being hand to mixed material pinches agglomerating, one pushes away namely the state that looses, the consumption of described 50% ethanol water be step 1. in raw materials used prescription gross weight 11.85%;
5. the softwood that 4. step is made is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, and oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
6. get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer essence is uniformly sprayed in dried fine silt surface, the dolomol that sprayed the dried fine silt of essence, dried particle and 0.95 part is mixed;
7. compressing tablet gets finished product behind the damp-prrof packing.
Embodiment 8
1. take by weighing each raw material in proportion
65 parts in honeycomb promotor composition ultra micro powder, 31.3 parts in filler sweet mellow wine, sweet 0.5 part of sweetener knob, 0.9 part in the mixture of any ratio of one or both in acid citric acid or the malic acid, 0.3 part of flavoring pineapple essence, 2 parts of dolomols;
2. 80 mesh sieves are standby after 31.3 portions of sweet mellow wine, 0.9 portion of acid being pulverized with pulverizer;
In 3. above-mentioned raw materials being filled a prescription: 31.3 parts in sweet mellow wine, acid after 65 parts in honeycomb promotor composition ultra micro powder, sweet 0.5 part of knob, the pulverizing are poured in the agitator groove together for 0.9 part and are stirred;
4. with sprayer 55% ethanol water is uniformly sprayed on 3. described mixed material surface and constantly mixing of step, being hand to mixed material pinches agglomerating, one pushes away namely the state that looses, the consumption of described 55% ethanol water be step 1. in raw materials used prescription gross weight 10.3%;
5. the softwood that 4. step is made is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, and oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
6. get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer essence is uniformly sprayed in dried fine silt surface, the dolomol that sprayed the dried fine silt of essence, dried particle and 2 parts is mixed;
7. compressing tablet gets finished product behind the damp-prrof packing.
Embodiment 9
Use the buccal tablet of embodiment 1 preparation to carry out the test of pesticide effectiveness, its effect is shown in table 1-table 4.The buccal tablet of other embodiment preparation also can reach following effect, does not elaborate at this.
(1) rhinitis chronic
1, diagnostic criteria
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease diagnosis criterion of therapeutical effect ", the dialectical standard of establishment rhinitis chronic is as follows:
1) with the long-term nasal obstruction that continues, or intermittent, property nasal obstruction alternately, the nasal mucus amount mostly is cardinal symptom.Or with diseases such as inaccessible senses in giddy, decrease of memory, insomnia, tinnitus, the ear;
2) course of disease is longer, tired, the cold back of sense sx.Easy concurrent ear expands, ear closes;
3) nasal cavity checks mucous hyperemia, takes on a red color or kermesinus, and schneiderian membrane swelling is based on concha nasalis inferior.
2, treatment grouping
1) treatment group patient man 66 examples, women 54 examples, 31～55 years old age; 35.2 years old mean age; The course of disease 1～8 year, average course of disease 2.5 years; For the reagent thing: the plain buccal tablet of honeycomb that the embodiment of the invention 1 is prepared; Usage and consumption: oral containing, one time 2 (1.2 gram/sheet), every day 5 times, 14 days is a course for the treatment of, treats 2 courses for the treatment of.
2) control group patient man 54 examples, women 45 examples, 30～58 years old age; 36.1 years old mean age; The course of disease 1～6 year, average course of disease 2.1 years; Control drug: the smart cream of honeycomb (41% self-control honeycomb element (the honeycomb alcohol extract B that the present invention is made and honeycomb water extract C mix and namely get self-control honeycomb element)+59% honey, down with); Usage and consumption: convert water and drink, one time 15～20 gram, every day 5 times, 14 days is a course for the treatment of, treats 2 courses for the treatment of.
3) two groups of patients have statistical significance (P＞0.05) at comparing difference aspect the physical data such as sex, age, the course of disease and tissue typing.
3, curative effect judging standard
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease diagnosis criterion of therapeutical effect ", curative effect determinate standard is as follows:
1) cure: transference cures such as nasal obstruction, runny nose, the nasal cavity inspection is normal;
2) effective: sxs such as nasal obstruction, runny nose, local sign is obviously improved;
3) do not heal: sings and symptoms does not have obvious improvement.
4, curative effect relatively
The treatment group is totally 120 examples, cures 84 examples, effective 31 examples, invalid 5 examples, total effective rate 95.8%.Control group is totally 99 examples, cures 22 examples, effective 35 examples, invalid 42 examples, total effective rate 57.6%.Two groups of curative effects compare, and treatment group total effective rate obviously is better than control group, and difference has conspicuousness meaning (* P＜0.01).
Table 1 pair rhinitis chronic curative effect comparison (n, %)
| Group | n | Cure | Effectively | Invalid | Total effective rate |
| The treatment group | 120 | 84（70） | 31（25.8） | 5（4.2） | 95.8* |
| Control group | 99 | 22（22.2） | 35（35.4） | 42（42.4） | 57.6 |
Annotate: compare * P＜0.01 with control group
(2) nasosinusitis
1, diagnostic criteria
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease diagnosis criterion of therapeutical effect ", the dialectical standard of establishment nasosinusitis is as follows:
1) with a large amount of viscosity or purulence nasal mucus, nasal obstruction, headache or giddy are cardinal symptom.Acute nasosinusitis occur together heat and general malaise;
2) acute nasosinusitis morbidity is rapid, and the course of disease is shorter.If treatment is not thorough, then delay is chronic nasosinusitis, and the course of disease is longer;
3) nasal cavity checks mucous hyperemia, swelling, and nasal cavity or choana have more viscosity or purulent secretion;
4) X line nasal sinus is taken the photograph sheet positive performance.Blood leukocytes sum and neutrophil leucocyte increase during acute attack.
2, treatment grouping
1) treatment group patient man 27 examples, women 23 examples, 12～68 years old age; 40.3 years old mean age; The course of disease 8 months～10 years, average course of disease 4.6 years; For the reagent thing: the plain buccal tablet of honeycomb that the embodiment of the invention 1 is prepared; Usage and consumption: oral containing, one time 2 (1.2 gram/sheet), every day 5 times, one month is a course for the treatment of, treats 3 courses for the treatment of.
2) control group patient man 29 examples, women 21 examples, 13～65 years old age; 38.5 years old mean age; The course of disease 5 months～8 years, average course of disease 3.9 years; Control drug: the smart cream of honeycomb; Usage and consumption: convert water and drink, one time 15～20 gram, every day 5 times, a month sky is a course for the treatment of, treats 3 courses for the treatment of.
3) two groups of patients have statistical significance (P＞0.05) at comparing difference aspect the physical data such as sex, age, the course of disease and tissue typing.
3, curative effect judging standard
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease diagnosis criterion of therapeutical effect ", curative effect determinate standard is as follows:
1) cure: transference cure, X line nasal sinus sheet is no abnormal;
2) effective: symptom is obviously improved, and the nasal cavity inspection sees that performances such as hyperemia, mucous membrane swelling alleviate.X line nasal sinus is taken the photograph sheet to be had and obviously changes the longevity;
3) do not heal: sings and symptoms does not have obvious improvement.
4, curative effect relatively
The treatment group is totally 50 examples, cures 22 examples, effective 18 examples, invalid 5 examples, total effective rate 92.4%.Control group is totally 50 examples, cures 14 examples, effective 16 examples, invalid 10 examples, total effective rate 63.4%.Two groups of curative effects compare, and treatment group total effective rate is apparently higher than control group, and difference has conspicuousness meaning (P＜0.05).
Table 2 pair nasosinusitis curative effect comparison (n, %)
| Group | n | Cure | Effectively | Invalid | Total effective rate |
| The treatment group | 50 | 22（44） | 18（36） | 5（10） | 80 |
| Control group | 50 | 14（28） | 16（32） | 10（20） | 60 |
Annotate: compare P＜0.05 with control group
(3) allergic rhinitis
1, diagnostic criteria
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease diagnosis criterion of therapeutical effect ", the dialectical standard of establishment allergic rhinitis is as follows:
1) with the paroxysmal rhiocnesmus, continuous sneeze, nasal obstruction, the clear rare amount of nasal mucus mostly is cardinal symptom, with anodimia, disease such as eye is itched, throat is itched;
2) onset is rapid, and symptom generally continues several minutes to tens of minutes, and the intermittent phase does not have sneeze and nasal obstruction, can concurrent nettle rash, disease such as asthma;
3) often fall ill because of sensitizers such as contact pollen, flue dust, chemical gas, variation of ambient temperature also can be brought out sometimes;
4) nasal cavity checks that mucous membrane mostly is pale, minority hyperemia, and concha swelling has more clear rare secretion during outbreak.
2, treatment grouping
1) treatment group patient man 55 examples, women 37 examples, 11～62 years old age; 39.3 years old mean age; The course of disease 8 months～8 years, average course of disease 3.7 years; For the reagent thing: the plain buccal tablet of honeycomb that the embodiment of the invention 1 is prepared; Usage and consumption: oral containing, one time 2 (1.2 gram/sheet), every day 3 times, 5 days is a course for the treatment of, treats 3 courses for the treatment of.
2) control group patient man 42 examples, women 32 examples, 10～65 years old age; 38.1 years old mean age; The course of disease 7 months～10 years, average course of disease 3.5 years; Control drug: the smart cream of honeycomb; Usage and consumption: convert water and drink, one time 15～20 gram, every day 3 times, 5 days is a course for the treatment of, treats 3 courses for the treatment of.
3) two groups of patients have statistical significance (P＞0.05) at comparing difference aspect the physical data such as sex, age, the course of disease and tissue typing.
3, curative effect judging standard
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease diagnosis criterion of therapeutical effect ", curative effect determinate standard is as follows:
1) cure: symptom, sign disappear, and do not have recurrence more than 3 months;
2) effective: symptom, sign alleviate during outbreak, and attack times reduces;
3) do not heal: symptom and sign do not have obvious improvement.
4, curative effect relatively
The treatment group is totally 92 examples, cures 48 examples, effective 37 examples, invalid 7 examples, total effective rate 92.4%.Control group is totally 74 examples, cures 22 examples, effective 25 examples, invalid 27 examples, total effective rate 63.4%.Two groups of curative effects compare, and treatment group total effective rate is apparently higher than control group, and difference has conspicuousness meaning (P＜0.05).
Table 3 pair allergic rhinitis curative effect comparison (n, %)
| Group | n | Cure | Effectively | Invalid | Total effective rate |
| The treatment group | 92 | 48（52.2） | 37（40.2） | 7（7.6） | 92.4 |
| Control group | 74 | 22（29.7） | 25（33.8） | 27（36.5） | 63.5 |
Annotate: compare P＜0.05 with control group
(4) chronic pharyngitis
1, diagnostic criteria
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease diagnosis criterion of therapeutical effect ", the dialectical standard of establishment chronic pharyngitis is as follows:
1) with pharyngeal drying, or itch, ache, foreign body sensation, swelling sense etc. is cardinal symptom;
2) course of disease is longer, and is heavy when light during pharyngeal malaise symptoms;
3) the acute throat obstruction history of repeated attack is often arranged, or because of the long-term mouth breathing of chronic rhinitis, or prisoner's tobacco and wine are excessive, and surrounding air drying, the different gas stimulation of dust etc. causes morbidity;
4) pharyngeal inspection mucous membrane swelling, or atrophy is arranged, or kermesinus patch shape, dendroid hyperemia are arranged.The lateral pharyngeal band enlargement, pharynx rear wall lymph foilicie hyperplasia.
2, treatment grouping
1) treatment group patient man 38 examples, women 22 examples, 20～60 years old age; 35.7 years old mean age; The course of disease 3 months～2 years, average course of disease 11 months; For the reagent thing: the plain buccal tablet of honeycomb that the embodiment of the invention 1 is prepared; Usage and consumption: oral containing, one time 2 (1.2 gram/sheet), every day 3～4 times, 7 days months is a course for the treatment of, treats 3 courses for the treatment of.
2) control group patient man 36 examples, women 24 examples, 20～58 years old age; 34.2 years old mean age; The course of disease 5 months～2 years, average course of disease 1.0 years; Control drug: the smart cream of honeycomb; Usage and consumption: convert water and drink, one time 15～20 gram, every day 3～4 times, 7 days is a course for the treatment of, treats 3 courses for the treatment of.
3) two groups of patients have statistical significance (P＞0.05) at comparing difference aspect the physical data such as sex, age, the course of disease and tissue typing.
3, curative effect judging standard
According to " traditional Chinese medical science hals,Nasen und Ohrenheilkunde disease diagnosis criterion of therapeutical effect ", curative effect determinate standard is as follows:
1) cure: pharyngeal transference cure checks normal;
2) effective: pharyngeal sings and symptoms obviously alleviates;
3) do not heal: sings and symptoms does not have significant change.
4, curative effect relatively
The treatment group is totally 60 examples, cures 36 examples, effective 20 examples, invalid 4 examples, total effective rate 93.3%.Control group is totally 60 examples, cures 20 examples, effective 22 examples, invalid 18 examples, total effective rate 70.0%.Two groups of curative effects compare, and treatment group total effective rate is apparently higher than control group, and difference has conspicuousness meaning (P＜0.05).
Table 4 pair chronic pharyngitis curative effect comparison (n, %)
| Group | n | Cure | Effectively | Invalid | Total effective rate |
| The treatment group | 60 | 36（60） | 20（33.3） | 4（6.7） | 93.3 |
| Control group | 60 | 20（33.3） | 22（36.7） | 18（30） | 70 |
Annotate: compare P＜0.05 with control group
Comprehensive above result of the test shows that the plain buccal tablet of the prepared honeycomb of the present invention all has significant clinical efficacy to rhinitis chronic, nasosinusitis, allergic rhinitis and chronic pharyngitis.
Obviously, the above embodiment of the present invention only is for example of the present invention clearly is described, and is not to be restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here can't give exhaustive to all embodiments.Everyly belong to the row that apparent variation that technical scheme of the present invention extends out or change still are in protection scope of the present invention.
Claims (10)
1. the plain buccal tablet of a honeycomb, it is characterized in that: the plain buccal tablet of this honeycomb is to be made by the raw material of following weight parts: 20～80 parts in honeycomb promotor composition ultra micro powder, 15～78 parts of fillers, 0.02～1.5 part of sweetener, 0.2～2 part of acid, 0.05～0.5 part of flavoring essence, 0.8～2 part of lubricant;
Wherein, described honeycomb promotor composition ultra micro powder is the ultra micro powder of the mixture of the plain freeze-dried powder of honeycomb and yam flour, and its fineness is 3000～3500 orders, and granularity is 5～4.5 μ m.
2. the plain buccal tablet of honeycomb according to claim 1, it is characterized in that: the mass ratio of the plain freeze-dried powder of described honeycomb and yam flour is 1:0.2～0.5.
3. the plain buccal tablet of honeycomb according to claim 1 and 2 is characterized in that, the plain freeze-dried powder of described honeycomb is to be prepared by following method:
(1) extract honeycomb alcohol extract B: with honeycomb after freezing under-15 ℃～-18 ℃ conditions, drop into extractor after being ground into meal, the edible alcohol that adds 3～4 times of its volumes, 10 ℃～25 ℃ are soaked and stirred 72～96 hours with 10～12 rev/mins rotating speed, filter through 60～80 keevil frames, get filter residue A, filtrate is 0.085～0.09MPa in vacuum, temperature is under 45 ℃～55 ℃ the condition, after vacuum concentrates honeycomb alcohol extract B;
(2) extract honeycomb water extract C: filter residue A is dropped into extractor, and add the pure water of 6～7 times of its quality, 80 ℃～85 ℃ are soaked and stirred 6～7 hours with 10～12 rev/mins rotating speed, filter through 60～80 keevil frames, remove filter residue, filtrate is 0.085～0.09MPa in vacuum, and temperature is under 65 ℃～70 ℃ the condition, after vacuum concentrates honeycomb water extract C;
(3) the plain freeze-dried powder of preparation honeycomb: honeycomb alcohol extract B and honeycomb water extract C mixed namely get the honeycomb element, this honeycomb element is put into vacuum freeze, first precooling, temperature is-2 ℃～-10 ℃, time is 1～1.5 hour, sharp freezing again, temperature are-10 ℃～-45 ℃, and the time is 0.5～4 hour, vacuumize then and heat, vacuum is 40～0.05 millimetress of mercury, and heating-up temperature is 15～20 ℃, gets the plain freeze-dried powder of honeycomb.
4. the plain buccal tablet of honeycomb according to claim 1 is characterized in that: described filler is one or more the mixture in sucrose, starch, dextrin, corn dextrin, improvement dextrin, glucose, lactose, maltitol, sorbierite, xylitol, sweet mellow wine, compound sugar, hydroxyl isomaltulose or the trehalose.
5. the plain buccal tablet of honeycomb according to claim 1 is characterized in that: described sweetener is that Aspartame, knob are sweet, one or more the mixture in Sucralose, stevioside or the glycyrrhizin.
6. the plain buccal tablet of honeycomb according to claim 1 is characterized in that: described acid is one or more the mixture in citric acid, tartaric acid, malic acid or the lactic acid.
7. the plain buccal tablet of honeycomb according to claim 1, it is characterized in that: described lubricant is dolomol.
8. preparation technology as the plain buccal tablet of the described honeycomb of the arbitrary claim of claim 1-7, it is characterized in that: this technology comprises the steps:
(1) prefabricated honeycomb promotor composition ultra micro powder;
(2) afterwards 80 mesh sieves are standby excessively with the pulverizer pulverizing with filler, acid;
(3) filler, acid after honeycomb promotor composition ultra micro powder, sweetener and the pulverizing are poured in the agitator groove together and stirred;
(4) with sprayer ethanol water is uniformly sprayed on the described mixed material of step (3) surface, and constantly stirring makes it to mix, obtain softwood;
(5) softwood of making is crossed the granulation of 20 order stainless (steel) wires with waving comminutor, oven dry with the whole grain of 16 order stainless (steel) wires, obtains dried particle;
(6) get dried particle and cross the dried fine silt that 30 order stainless (steel) wires sift out, with sprayer flavoring essence is uniformly sprayed in dried fine silt surface, dried fine silt, dried particle and the mix lubricant that sprayed edible essence is even;
(7) compressing tablet gets finished product behind the damp-prrof packing.
9. preparation technology according to claim 8, it is characterized in that: the method for described prefabricated honeycomb promotor composition ultra micro powder is:
(1) extract honeycomb alcohol extract B: with honeycomb after freezing under-15 ℃～-18 ℃ conditions, drop into extractor after being ground into meal, the edible alcohol that adds 3～4 times of its volumes, 10 ℃～25 ℃ are soaked and stirred 72～96 hours with 10～12 rev/mins rotating speed, filter through 60～80 keevil frames, get filter residue A, filtrate is 0.085～0.09MPa in vacuum, temperature is under 45 ℃～55 ℃ the condition, after vacuum concentrates honeycomb alcohol extract B;
(2) extract honeycomb water extract C: filter residue A is dropped into extractor, and add the pure water of 6～7 times of its quality, 80 ℃～85 ℃ are soaked and stirred 6～7 hours with 10～12 rev/mins rotating speed, filter through 60～80 keevil frames, remove filter residue, filtrate is 0.085～0.09MPa in vacuum, and temperature is under 65 ℃～70 ℃ the condition, after vacuum concentrates honeycomb water extract C;
(3) the plain freeze-dried powder of preparation honeycomb: honeycomb alcohol extract B and honeycomb water extract C mixed namely get the honeycomb element, this honeycomb element is put into vacuum freeze, first precooling, temperature is-2 ℃～-10 ℃, time is 1～1.5 hour, sharp freezing again, temperature are-10 ℃～-45 ℃, and the time is 0.5～4 hour, vacuumize then and heat, vacuum is 40～0.05 millimetress of mercury, and heating-up temperature is 15 ℃～20 ℃, gets the plain freeze-dried powder of honeycomb;
(4) preparation honeycomb promotor composition ultra micro powder: be that 1:0.2 places trough type mixing machine according to mass ratio with the plain freeze-dried powder of honeycomb and yam flour, mixed 20～30 minutes, use Universalpulverizer to pulverize once in this mixture, again the mixture after the above-mentioned pulverizing is placed micronizer to pulverize, compressed air pressure is adjusted into 10MPa, obtains the honeycomb promotor composition ultra micro powder of fineness 3000～3500 orders, granularity 5～4.5 μ m.
10. preparation technology according to claim 8 is characterized in that: the concentration of ethanol water is 30%～60% in the described step (4), and the consumption of ethanol water is 5.5%～12% of the plain buccal tablet composition of raw materials of honeycomb gross weight.
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| CN103230012B (en) | 2015-01-28 |
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