KR101419463B1 - Herbal composition for prevention and treatment of hepatic disease - Google Patents

Abstract

The present invention relates to a herbal composition which contains Trichinaceae and Echinacea as essential medicinal materials, and which contains, as main medicinal ingredient, black shrub or woam as main medicinal materials and in-situ gold as an auxiliary medicinal material, Can be provided as a pharmaceutical composition for prevention and treatment of liver disease, and can be provided as a health food for prevention and improvement of liver disease.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a herbal composition for prevention and treatment of liver disease,

The present invention relates to a herbal composition for prevention and treatment of liver diseases, which contains Trichinella root, Corynebacterium glutinosa, Black shrub, Woam, and interstitial gold as active ingredients.

The liver is the largest organ in our body located in the upper right part of the abdomen under the diaphragm. The liver is the largest organ in the human body, weighing 1 to 1.5 kg, and the size is about the sum of both palms. It is located in the right upper abdomen beneath the diaphragm and the normal person is reddish. The liver is protected by a rib in the future, and the upper part is in contact with the diaphragm and has a round shape. The liver is divided into the right lobe and the left lobe. The quadrate lobe and the caudate lobe are located between the two lobes. The shape is like a rounded triangle, with the right lobe being 5 times larger and thicker than the left lobe. In the area of the right lobe and the left lobe, the hepatic portal artery, the bile duct, and the lymphatic duct are connected.

The liver consists of hepatocytes (parenchymal cells), Kupffer cells, capillaries, ciliary ducts, intrahepatic bile ducts, extrahepatic bile ducts and gallbladder, arteriovenous, lymphatic vessels, These constituent cells become one body to form primary liver lobes and these liver lobules are stacked to form liver. Liver lobules are the smallest units that can function in the liver, and hepatocytes are arranged and cooper cells are associated with them. In the liver lobules, blood vessels, lymphatic vessels, and bile ducts stretch like spider webs. These fine tubules gradually gather into large stems as they go out of the liver and form large blood vessels or biliary ducts. In the center of the hepatic lobule, a central vein passes through and a hepatic cell cord, a group of hepatocytes, is arranged in a fan shape.

Interpretation of the function of liver lobes as a function of liver function is also the minimum unit of interlobular function. Hepatocytes are composed of minute mitochondria, microsomes, and nuclei. Mitochondria convert glucose and fatty acids to carbon dioxide and water, then generate energy, which is used for various synthesis reactions (protein and glycogen synthesis). Microsomes allow amino acids to combine to synthesize proteins.

The liver is the backbone of internal organs and its action is very complicated and there are many opportunities to get in contact with harmful substances and bacteria, and the appearance of the disease also varies. Thus, liver disease can range from mild to death. The most common hepatitis in liver disease is acute and chronic. In general, acute hepatitis is easy to treat and positive. Acute hepatitis is caused by viral hepatitis, alcoholic hepatitis, and addictive hepatitis. Among the liver diseases, hepatitis caused by viruses is the most frequently found. Hepatitis A caused by hepatitis A virus is also known as epidemic hepatitis, and it is transmitted by food and feces, but it is rarely chronicized because the virus is expelled relatively quickly. Hepatitis B, which is caused by infection with hepatitis B virus, is also called serum hepatitis and infection rate is very high through blood transfusion, so it can happen infectiously from mother to child as well as from hospital. Chronic hepatitis often occurs when a person is infected. When chronic hepatitis worsens, so-called cirrhosis and liver cancer develop. It is cirrhosis that people who drink and drink are the most afraid. This liver cirrhosis is a disease in which a part of the liver is dying and instead of it, fibers are formed and become hard as stones. If it gets worse, it is a terrible disease that leads to death and it is a tendency to increase rapidly recently. Alcoholic liver disorder is a liver disease caused by overeating of alcohol. It is better if you break alcohol, but if it continues to be burdened, it becomes hepatitis and cirrhosis. In Korea, cancer occurs in the liver, and many liver cancers such as the stomach and pancreas are present. Hepatic atrophy (dramatic hepatitis), which rapidly shrinks the liver, can lead to acute hepatitis to hepatic coma and may die within days. Liver abscess is a disease in which the liver is partly formed by bacteria, feces, and amoeba. Fatty liver, which is a metabolic disease in which liver fat accumulates due to drinking too much alcohol, obesity, and diabetes, is also rapidly increasing. Medicinal liver disorder is a kind of foreign substance in the body, so the liver is metabolized and excreted. It is called addictive hepatic disorder that liver damage is caused by side effects such as anticancer drugs and antibiotics while taking a large amount of drugs for a long period of time. The synthesis of proteins by hepatocytes is hampered by the drug, and the protein needed to transport the fat from the liver is insufficient to become fat in the hepatocytes. Or drug-sensitized hepatopathy is caused by only one person sensitive to each drug depending on the type of drug. Other special cases include syphilis and Wilson's disease. From the liver to the duodenum to the use of an overview or gallbladder, cholangitis or cholecystitis is prone to cause, cancer often appears in other uses. This is called biliary cancer. Cholelithiasis can also precipitate cholesterol, which is a solid component in the bile, that can cause stones, block the bile, and cause severe pain. And in these liver and biliary diseases, digestive or metabolic disorders, jaundice, sometimes with yellowing of the eyes or skin, may occur. Bilirubin from hemoglobin, which comes from the breakdown of reticulocytes, appears yellow in the blood, which is caused by interfering with the discharge from the liver to the bile.

Ursodeoxycholic acid, immunostimulants, antivirals, silymarin, fingi polysaccharide, vitamin B group, and methionine are the most commonly used drugs for the prevention and treatment of hepatitis and cirrhosis. None of these drugs There has not yet been a clinically satisfactory effect. For the treatment of hepatocellular carcinoma, resection of the cancerous site is known to be the most effective method. However, if surgery is dangerous or can not be performed depending on the condition of the disease, anticancer drugs should be used. In this case, hepatocarcinoma is injected directly into hepatocarcinoma through the hepatic artery, and after treatment with anticancer drug, a treatment method for occluding blood vessels connected with carcinoma is widely used. Since most of the liver cancer leads to death, prevention should be given priority over the treatment of the already-developed liver cancer. Currently, the only way to vaccinate is vaccination for this purpose.

As a composition for treating liver disease using the herbal composition, for example, Korean Patent Laid-Open No. 10-1999-0038424 discloses a composition containing four herbal medicines, The present invention relates to a herbal composition comprising 10 kinds of herbal medicines having excellent prophylactic and therapeutic effects against sexually transmitted hepatitis B and 10 kinds of herbal medicines such as Bacillus thuringiensis, Bacillus thuringiensis, Bacillus thuringiensis, Bacillus thuringiensis, , Korean Patent Laid-Open No. 10-2006-0104405 discloses an oral herbal composition having an effect of preventing and treating liver and liver cirrhosis, and Korean Patent Laid-Open No. 10-2006-0104405 discloses an oral herbal composition for preventing liver cirrhosis, The present invention relates to a composition comprising at least one compound selected from the group consisting of at least one compound selected from the group consisting of at least one compound selected from the group consisting of at least one compound selected from the group consisting of at least one compound selected from the group consisting of: However, as in the present invention, there was no composition for prevention and treatment of liver diseases including a composition consisting of Tricholoma, Ulysses, Black shrub, Wool Dam, and Trehalose.

Accordingly, the present inventors have found that, in a rat having liver damage caused by galactosamine, a composition containing an effective ingredient of Trichinaceae, Uric (or turmeric), black shafts, Significantly reduce liver damage in ethanol-induced liver damage, significantly reduce lipid and cholesterol levels, and significantly reduce hepatic levels in hepatitis-inducing rats. Clinical trials have also shown a significant reduction in liver levels in human liver disease The present invention has been completed.

It is an object of the present invention to provide a pharmaceutical composition for preventing and treating liver disease comprising 20 to 40 parts by weight of Panax notoginsengs and 15 to 25 parts by weight of Curcum longa as an active ingredient.

Another object of the present invention is to provide a pharmaceutical composition containing 20 to 40 parts by weight of corn steep liquor, 15 to 25 parts by weight of corn, 15 to 25 parts by weight of black shrub (Pharbitis nil) or 5 to 15 parts by weight of Bos taurus var. Domesticus And to provide a pharmaceutical composition for preventing and treating liver diseases.

It is still another object of the present invention to provide a method for producing an active ingredient, which comprises 20 to 40 parts by weight of corn jelly, 15 to 25 parts by weight of corn, 15 to 25 parts by weight of a black shale, 5 to 15 parts by weight of a humectant, And to provide a pharmaceutical composition for preventing and treating liver diseases.

Another object of the present invention is to provide a health food for prevention and improvement of liver disease comprising 20 to 40 parts by weight of Panax notoginsengs and 15 to 25 parts by weight of Curcum longa as an active ingredient.

Another object of the present invention is to provide a pharmaceutical composition containing 20 to 40 parts by weight of corn steep liquor, 15 to 25 parts by weight of corn, 15 to 25 parts by weight of black shrub (Pharbitis nil) or 5 to 15 parts by weight of Bos taurus var. Domesticus And to provide a health food for prevention and improvement of liver disease.

It is still another object of the present invention to provide a method for producing an active ingredient, which comprises 20 to 40 parts by weight of corn jelly, 15 to 25 parts by weight of corn, 15 to 25 parts by weight of a black shale, 5 to 15 parts by weight of a humectant, And to provide a health food for prevention and improvement of liver disease.

In order to achieve the above object, the present invention provides a herbal composition comprising 20 to 40 parts by weight of herring root as an active ingredient and 15 to 25 parts by weight of herring as an effective ingredient, A pharmaceutical composition for prevention and treatment of liver disease.

The present invention also relates to a method for producing a liver comprising 20 to 40 parts by weight of Tricholoma herbaceousum, 15 to 25 parts by weight of Chinese ginseng, 15 to 25 parts by weight of black shrub (Pharbitis nil) or 5 to 15 parts by weight of Bos taurus var. Domesticus A pharmaceutical composition for preventing and treating diseases is provided.

The present invention also relates to a composition containing 20 to 40 parts by weight of Trichinella crassifolia, 15 to 25 parts by weight of Chinese gypsum, 15 to 25 parts by weight of a black shale, 5 to 15 parts by weight of a humectant, and 15 to 25 parts by weight of an internal gold A pharmaceutical composition for the prevention and treatment of liver disease is provided.

The present invention also provides a health food for prevention and improvement of liver disease comprising 20 to 40 parts by weight of Panax notoginsengs and 15 to 25 parts by weight of Curcum longa as an active ingredient.

The present invention also relates to a method for producing a liver comprising 20 to 40 parts by weight of Tricholoma herbaceousum, 15 to 25 parts by weight of Chinese ginseng, 15 to 25 parts by weight of black shrub (Pharbitis nil) or 5 to 15 parts by weight of Bos taurus var. Domesticus Thereby providing a health food for preventing or ameliorating disease.

The present invention also relates to a composition containing 20 to 40 parts by weight of Trichinella crassifolia, 15 to 25 parts by weight of Chinese gypsum, 15 to 25 parts by weight of a black shale, 5 to 15 parts by weight of a humectant, and 15 to 25 parts by weight of an internal gold A health food for prevention and improvement of liver disease is provided.

The composition according to the present invention remarkably reduces liver levels in rats suffering from liver damage by galactosamine, significantly decreases lipid and cholesterol even in ethanol induced liver damage, and remarkably decreases hepatic levels in hepatitis inducing rats Therefore, the present invention can be effectively used as a pharmaceutical composition for the prevention and treatment of liver disease, since it has an effect of remarkably reducing liver levels in human liver diseases even in clinical trials.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagram showing a method for producing a herbal composition comprising a mixture of Tricholoma matsutake, Ulysum, Black shrub, Wuham, and interstitial gold.
Fig. 2 is a view showing a method for producing a herbal composition composed of malt instead of danshen and in-situ gold instead of whiting in Samjitsu, kokyu, black shark, woam, and in-situ gold.

Hereinafter, the present invention will be described in detail.

The present invention provides a pharmaceutical composition for the prevention and treatment of liver diseases, which contains Tricholoma mucilaginosa and Echinosophora as an active ingredient.

It is the roots of Panax notoginsengs (Burk) FH Chen: 三七). It is used for bleeding symptoms such as bleeding, hemorrhage, hemorrhage, hemoptysis, hemorrhage, hemorrhage, tympanic fracture, abdominal pain due to hemorrhage, boils, pain, and postpartum. . Pharmacological actions have been reported such as shortening of blood coagulation time, anti-fatigue effect, blood pressure reduction, cardiac pace relaxation, increase of coronary blood flow, lipolytic action, liver function enhancement and activation of immune function. It is conical in shape and has a stalk attached to the muscular head, and there is a small horn-shaped protrusion around it. Outer surface is grayish brown or grayish yellow with vertical wrinkles and thin roots attached. The cut surface is dark brown with a radial pattern, and the quality is heavy and hard.

Curcuma longa Linne, a ginger plant in Korea, is the root of the root of the root, or steamed and dried. In China, curcuma kwangsiensis SG Lee & CF Liang, Curcuma wenyujin YH Chen & C. Ling, Curcuma phaeocaulis Valeton, Of the root. It has similar appearance to turmeric, but both sides of the leaf are smooth. It grows naturally in Southeast Asia including southern China, India, and Okinawa, and is cultivated in the southern part of Korea. When mixed with alcohol, it was named as yellow, like gold. It is called magic because its shape is similar to that of astringent and it treats horse disease. This medicine has a peculiar smell, chews the sting, and it is irritating. The taste is spicy and the quality is cool. Ulgum communicates the muscles and helps the blood circulation to cure menstrual cramps, menstrual irregularities and flank pain, treats blood clots, nosebleeds, papules, cleanses the mind, removes the victims' parts and promotes bile secretion and treats gallstones. Pharmacological actions have been reported to reduce bile secretion, excretion, and the formation of nodules in the coronary arteries. Appearance can be divided into the root and stem. The stem is ovate, and the stem is a dull columnar shape with both ends bent slightly and has side buds. It is yellowish brown and glossy with juzi. It has a dark reddish-brown color and a reddish-brown powder on its outer surface. Other names include magic, 黄 鬱, 金 金, 乞 金, 玉 金, 王 金, and 黄黄. Ulugum has been recorded since BC and has been used as a coloring agent for dyes and foodstuffs and is the raw material for Indian curry. In Japan, it is used as a coloring material for radishes, and it is cultivated as a special crop in Okinawa, Japan, known as a world longevity village, and is used as a health food.

The molasses can be replaced by turmeric.

Curcuma longa is a perennial plant belonging to the ginger family. It is mainly cultivated in tropical and subtropical regions, mainly India, and uses stem and root for edible and medicinal purposes. It is cultivated in India, China, Southeast Asia and many other countries. Korea is cultivated in Jindo in Jeonnam, Haenam in Chonnam, Buan in Jeonbuk, Siheung in Gyeonggi, and Cheongyang in Chungnam. The flower ear emerges before the leaf, is wide egg-shaped and is wrapped in a pale green can. Yellow flowers bloom from April to June in the axilla. The upper bract is slightly narrower of the butterfly, the tip is fuchsia, and the flower does not run on the leaf axil. Root stalk is light yellow on the outside and scarlet is scarlet like camphor. Rootstocks and root roots are both used as herbal medicines. Rootstocks are called turmeric and root roots are steamed and dried. It is said to be effective for pain relief and menstrual irregularities. It is said to be used as a medicine for bruises and sprains in India and as a spice for curry powder.

In the present invention, the triangular crest includes 20 to 40 parts by weight, preferably 30 parts by weight. The molasses may include 15 to 25 parts by weight, preferably 20 parts by weight. The sulfur content includes 15 to 25 parts by weight, preferably 20 parts by weight.

In one embodiment of the present invention, the composition is effective for the prevention and treatment of liver disease and includes, but is not limited to, hepatitis, liver cirrhosis, hepatic abscess, liver metastasis, liver cancer, hepatic necrosis, passive congestion or hepatitis .

Hepatitis may include, but is not limited to, chronic hepatitis, acute hepatitis, and acute hepatitis may include, but is not limited to, viral infection by microbial infection and toxic hepatitis by drug, alcohol, . Chronic hepatitis is not limited to this, but clinically refers to the persistence of hepatic impairment after a period of 6 months or more after the onset of acute hepatitis. Current diagnostic criteria are liver histological changes by liver biopsy, There is a persistent inflammatory response, mainly in the second, involving the infiltration of protoplasts and the enlargement of the context due to fiber proliferation.

Liver cirrhosis refers to the transformation of normal liver tissue into fibrotic tissue, such as regenerative nodules, due to chronic inflammation, which may impair hepatic function, including but not limited to chronic hepatitis B Hepatitis C, cirrhosis caused by persistent over-smoking and the use of hepatic toxicants.

Liver abscess refers to the destruction of normal hepatocytes and liver tissue by infection of microorganisms and the formation of pus in situ, including, but not limited to, pyogenic liver abscess and amoebic liver abscess.

Liver cancer refers to a tumor that develops in the liver and includes, but is not limited to, hepatocellular adenoma, intrahepatic bile duct adenoma, cholangiocarcinoma, hepatoblastoma, hepatic angiosarcoma hemangiosarcoma, carcinoid, myelolipoma, and fibrosarcoma.

Hepatic jaundice refers to benign lesions in which blood is surrounded by hepatocytes or endothelial cells, and may include phlebectatic type or parenchymal type.

Although hepatic necrosis is not limited to this disease, it can be divided into three categories: zonal necrosis, centrilobular necrosis, midzonal necrosis, periportal necrosis, paracentral necrosis, (bridging necrosis), massive necrosis, and focal necrosis.

Hepatic degeneration may include, but is not limited to, fatty liver, glycogen deposition, pigmentation, amyloid deposition, hemosiderin deposition.

Passive congestion may include acute passive congestion or chronic passive congestion.

In one embodiment of the present invention, the composition for prevention and treatment of liver disease, which contains 30 parts by weight of Trichomomonas rhizoma and 20 parts by weight of Korean ginseng as an active ingredient, is characterized in that in a rat in which liver damage is caused by galactosamine, Induced hepatic injury, significantly decreased lipid and cholesterol levels, and significantly reduced hepatic levels in hepatitis-induced rats (see Tables 1, 2 and 3).

The present invention also provides a pharmaceutical composition for prevention and treatment of liver disease, which comprises Aspergillus oryzae as a active ingredient.

Black shark is said to be the seed of Pharbitis nil Choisy. Morning glory is native to tropical Asia, such as India, and is known to have about 256 varieties. Black seeds are also called black sharks and white seeds are called white sharks. The name Kim Jin means the shape of the seed, and the names of 盆 甑 and 狗 耳 are attached to the shape of the petal. It is a bit smelly, irritating, tastes worn, cold and poisonous. The black axis is used when the rejuvenation is due to chronic pyelonephritis, cirrhosis and the like when the body is swollen and the diuretic action is strong and the diuretic action is strong. It is effective for seawater, asthma, stubborn constipation, parasite removal. A strong subcutaneous effect has been reported with pharmacological action and intestinal peristalsis. The shape of the bead is 4 ~ 6 vertically, and its outer surface is black ~ grayish brown or grayish white, smooth or slightly oval. In the magnifying glass, the outer surface of the seeds has short hairs, and the bottom of the ridge line is narrowed. The transverse surface is fan shaped and has a light yellowish brown to pale grayish brown color and the quality is dense. The seed coat is thin, its outer layer is dark gray, and the inner layer is light gray. There are 耳 草, 白 牛 牛, 白 丑, 盆 甑 草, 金 령), and 黑 牛 牛.

In the composition consisting of trichomes, ugly and black shrubs of the present invention, ganoderma can be used instead of sulfur.

In one embodiment of the present invention, the composition is effective for the prevention and treatment of liver disease and includes, but is not limited to, hepatitis, liver cirrhosis, hepatic abscess, liver metastasis, liver cancer, hepatic necrosis, passive congestion or hepatitis .

In the present invention, the triangular crest includes 20 to 40 parts by weight, preferably 30 parts by weight. The molasses may include 15 to 25 parts by weight, preferably 20 parts by weight. The black shroud includes 15 to 25 parts by weight, preferably 20 parts by weight.

In one embodiment of the present invention, the composition containing 30 parts by weight of Trichinella crassifolia, 20 parts by weight of coral fiber and 20 parts by weight of the black shrink as an active ingredient significantly lowered liver levels in rats caused liver damage by galactosamine, Induced hepatic injury significantly decreased lipid and cholesterol levels and significantly decreased hepatic levels in hepatitis inducing rats.

The present invention also provides a composition for prevention and treatment of liver disease, which contains Trichinella root, Ulgiata, and Wuham as active ingredients.

Domesticus, Bubalus bubalis) is an efficacy that brightens the eyes with the gall bladder of cattle, it helps the follicles, the intestines, the detoxification and the edema. It is known as a medicinal product.

In one embodiment of the present invention, the humor is preferably, but not exclusively, a right bile.

In the composition of the present invention, the humor is not limited thereto, but may preferably be replaced by fresh ginseng.

Danshen (丹 蔘) is a perennial herbaceous plant belonging to the family Lamiaceae and resembles the shape of ginseng and is called red ginseng. The scientific name is Salvia miltiorrhiza BUNGE. It is 40 ~ 80㎝ high and has many hairs throughout. Leaves face ovate or lanceolate. On the back is densely-hairy, dull serrations. Flowers are purple and bloom in May ~ June, and they run on the stratum. Roots are used as medicinal herbs. Tannin and Vitamin E are contained. In animal experiments, peripheral blood vessels were expanded and blood pressure was lowered. Medicinal herbs are slightly cold and flavorful, but they have antimicrobial action against Staphylococcus aureus, Escherichia coli, Typhoid bacteria and Mycobacterium tuberculosis. Myocardial infarction is used in combination with monkeys and congratulations, and the symptoms of insomnia and anxiety caused by nervous breakdown are treated by using a keel, It is known that the efficacy is also recognized in the early symptoms of chronic cirrhosis, liver dysfunction, and cirrhosis when the dysmenorrhea, menstrual irregularity and postpartum pain in the abdomen are severe.

In one embodiment of the present invention, the composition is effective for the prevention and treatment of liver disease and includes, but is not limited to, hepatitis, liver cirrhosis, hepatic abscess, liver metastasis, liver cancer, hepatic necrosis, passive congestion or hepatitis .

In the present invention, the triangular crest includes 20 to 40 parts by weight, preferably 30 parts by weight. The molasses may include 15 to 25 parts by weight, preferably 20 parts by weight. 5 to 15 parts by weight, and preferably 10 parts by weight.

In one embodiment of the present invention, a composition containing 30 parts by weight of Tricholoma aspartame, 20 parts by weight of Aspergillus and 10 parts by weight of Aspergillus as active ingredients significantly lowered liver levels in rats caused liver damage by galactosamine, Induced liver damage, significantly decreased lipid and cholesterol, and significantly reduced hepatic levels in hepatitis-induced rats (see Tables 1, 2 and 3).

The present invention also provides a composition for prevention and treatment of liver disease, which comprises Aspergillus nigrum, Aspergillus, Black shrub, and Wuham as active ingredients.

In the above composition, Korean ginseng can be used instead of sulfuric acid, and whiskers can be used by replacing fresh ginseng.

In the present invention, the triangular crest includes 20 to 40 parts by weight, preferably 30 parts by weight. The molasses may include 15 to 25 parts by weight, preferably 20 parts by weight. The black shroud includes 15 to 25 parts by weight, preferably 20 parts by weight. 5 to 15 parts by weight, and preferably 10 parts by weight.

In one embodiment of the present invention, a composition containing 30 parts by weight of Trichinilose, 20 parts by weight of corn, 20 parts by weight of black shafts and 10 parts by weight of Folium as an active ingredient is administered to a rat in which liver damage has been caused by galactosamine, (See Tables 1, 2 and 3), and significantly decreased lipid and cholesterol, even in ethanol induced liver damage, and significantly decreased liver levels in hepatitis-induced rats. In addition, it was confirmed that the composition of the present invention significantly reduced the liver level,

The present invention also provides a composition for prevention and treatment of liver diseases, which comprises Aspergillus oryzae, Eucalyptus, Black shrub, Wuham, and Trehalose as active ingredients.

In-situ gold refers to the inner membrane of a sand bag of chicken (Gallus domesticus Brisson) with a pheasant. Gold in the stomach is fragile and can not digest well. When the appetite is low, it is used for diaper such as vomiting, digestive disorder, bloating, abdominal distension. It is also used for symptoms such as urination, oil wells, and the like. Gastric secretion and gastrointestinal motility, phagocytosis, and anticancer effects were reported as pharmacological actions. The shape is a fragment of a broken circular shape which is not uniform in shape and has wavy wrinkles. It is yellow or yellowish brown with a width of 3 ~ 5㎝ and a thickness of 3㎜. It has a glossy and firm quality. The folded surface is colloidal and glossy and the vagina is hard and brittle. The drug should be large, thin, gold-pored, with lots of rounded protuberances. Other names include gypsy gypsy, gypsy, gypsy, gypsy blooms, and tzies.

In the above composition, corn can be used instead of sulfur, corn can be used instead of corn, and in-situ gold can be used by replacing malt.

Malt (germ) is a medicinal product made by sprouting, drying and then lightly roasting Hordeum vulgare Linne (barley). The malt was also called an umi (蘖 米), which is a word that calls the stem of a blanket called a barb. It is used to mean to save a person by using living things similar to Earl, which means not being alive. This medicine has a sweet smell. The taste is slightly sweet, and the quality is warm. Malt is effective against digestive disorders due to weakness of the nose, especially for the indigestion of flour food. It also has an effect on lack of milk secretion. Pharmacological actions have been reported to promote digestion and hypoglycemic effects. The malt is hard, its bud is within 2cm and it is yellow. There are young shoots on one end, young roots on the other, light yellow on the outside, and milky white. Quality is hard and fragile. The tongues of malt are large malt, big malt, big malt, vein, and valley.

In the present invention, the triangular crest includes 20 to 40 parts by weight, preferably 30 parts by weight. The molasses may include 15 to 25 parts by weight, preferably 20 parts by weight. The black shroud includes 15 to 25 parts by weight, preferably 20 parts by weight. 5 to 15 parts by weight, and preferably 10 parts by weight. The in-situ gold may include 15 to 25 parts by weight, preferably 20 parts by weight.

In one embodiment of the present invention, a composition containing 30 parts by weight of Trichinella crassifolia, 20 parts by weight of coral fiber, 20 parts by weight of black shale, 10 parts by weight of folium and 20 parts by weight of gold in an active ingredient is galactosamine, (Table 1, 2, and 3). The results are shown in Table 1, 2, and 3, in which the liver levels in the rats were remarkably lowered and the liver-induced hepatic injury was significantly decreased in the lipid and cholesterol levels and the liver levels were significantly reduced in the hepatitis-induced rats. In addition, it was confirmed that the composition of the present invention significantly reduced the liver level,

In one embodiment of the present invention, the composition containing 30 parts by weight of Trichinella, 20 parts by weight of corn, 20 parts by weight of black shale, 10 parts by weight of beeswax and 20 parts by weight of gold in the active ingredient is used for patients with hospitalized liver disease One clinical study confirmed that liver levels were significantly reduced.

In a specific embodiment of the present invention, the composition according to the present invention can significantly reduce abnormal liver waters in liver disease, and thus can be usefully used in pharmaceutical compositions for the prevention and treatment of liver diseases.

The composition according to the present invention preferably comprises the above herbal medicine in an amount of 0.1 to 50% by weight based on the total weight of the composition, but is not limited thereto.

The compositions according to the present invention may further comprise suitable carriers, excipients and diluents conventionally used in the manufacture of medicaments.

The composition according to the present invention may be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, etc., oral preparations, suppositories and sterilized injection solutions according to a conventional method have. Examples of carriers, excipients and diluents that can be included in the composition of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, Cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid form preparations for oral administration include tablets, pills, powders, granules, capsules and the like, which may contain at least one excipient such as starch, calcium carbonate, sucrose, (sucrose), lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included . Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of suppository bases include witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like.

The composition according to the present invention may be administered orally or parenterally. Any parenteral administration method may be used, and systemic administration or topical administration is possible, but systemic administration is more preferable, and intravenous administration is most preferable.

The preferred dosage of the composition according to the present invention varies depending on the condition and body weight, the degree of the disease, the drug form, the administration route and the period, but can be appropriately selected by a person having ordinary skill in the art to which the present invention belongs . Preferably, the therapeutic composition of the present invention is administered at a dose of 0.0001 to 1000 mg / kg per day based on the amount of the mixed herbal medicine, and 0.01 to 100 mg / kg per day to be more effective. The administration may be carried out once a day or divided into several times. The dose and the number of administrations do not limit the scope of the present invention in any aspect.

The composition according to the present invention may be administered to a patient in a single dose by bolus administration or by infusion for a relatively short period of time, May be administered by a fractionated treatment protocol. The dosage of the pharmaceutical composition of the present invention is determined in consideration of various factors such as the route of administration and the number of treatments as well as the age and health condition of the patient as well as the effective dose of the patient. Those skilled in the art will be able to determine an appropriate effective dose.

The composition may contain, in addition to the mixed preparation, a nutrient, a vitamin, an electrolyte, a flavoring agent, a coloring agent, a stabilizer, a pectic acid and a salt thereof, an alginic acid and its salt, an organic acid, a protective colloid thickener, a pH adjusting agent, a stabilizer, A carbonating agent used in a carbonated drink, and the like. The components may be added to the composition independently or in combination. The content of the additional component may be preferably in the range of 0.1 to 20 parts by weight per 100 parts by weight of the mixed preparation

The pharmaceutical composition of the present invention may be formulated into a unit dose form by formulating it using a pharmaceutically acceptable carrier and / or excipient according to a method which can be easily carried out by a person having ordinary skill in the art to which the present invention belongs. Or by intrusion into a multi-dose container. The formulations may be in any form suitable for pharmaceutical preparations including oral formulations such as powders, granules, tablets, capsules, suspensions, emulsions, syrups and aerosols, external preparations such as ointments and creams, suppositories and sterile injectable solutions .

The composition of the present invention is preferably, but not limited to, prepared by a manufacturing method comprising the following steps.

(1) mixing 30 parts by weight of Tricholoma, 20 parts by weight of corn, 20 parts by weight of a black shaft and 20 parts by weight of gold in situ; (2) extracting the mixture of step (1) with hot water to prepare an extract; (3) concentrating and drying the extract of step (2); (4) drying the bovine bile weight portion without boiling; (5) a step of mixing the dried material of step (3) and the dried material of step (4) (10 parts by weight) and pulverizing the mixture.

In step (1), the sensory test can be preferably carried out. The sensory test can confirm the appropriateness of the medicinal site, whether it is cleaned, whether it is dry, mixed with non-medicinal sites, or mixed with foreign matter.

In step (2), though not limited thereto, purified water in an amount of 6 to 12 times of the herbal medicine may be added, followed by extraction at 80 to 150 ° C for 2 to 6 hours to filter the extract. The amount of purified water to be blended is preferably 8 to 10 times that of the herbal medicine. The extraction temperature may be 80-150 캜, preferably 100-105 캜. The extraction time can be 2 to 6 hours, preferably 4 hours.

In the step (3), the step of concentration under reduced pressure may be carried out at 10 to 60 ° C, preferably at 60 ° C or less, but is not limited thereto.

In the step (4), the right bile can be dried separately without boiling, and the dried product of step (3) and step (4) can be pulverized and filled into capsules.

In the method according to the present invention, the number of times of extraction is preferably one to five times, but is not limited thereto.

The above extraction method may be a method using an extraction device such as hot water extraction, immersion extraction, reflux cooling extraction, supercritical extraction, subcritical extraction, high temperature extraction, high pressure extraction or ultrasonic extraction, or using an adsorption resin containing XAD and HP-20 Method and the like, and ultrasonic extraction is preferably performed at a low temperature, but the present invention is not limited thereto.

The present invention provides a health food for prevention and improvement of liver disease, wherein the composition contains Tricholoma matsutake and Echinacea as active ingredients. The active ingredient may further contain black shafts, beeswax, or in-situ gold, and may be substituted with turmeric, turmeric, and in-vitro malt.

In a specific embodiment of the present invention, the composition according to the present invention can significantly reduce abnormal liver waters in liver disease, and thus can be usefully used in health foods for prevention and improvement of liver diseases.

There is no particular limitation on the kind of the food. Examples of the foods to which the above substances can be added include dairy products including dairy products such as drinks, meat, sausage, bread, biscuits, rice cakes, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, ice cream, Beverages, alcoholic beverages, and vitamin complexes, all of which include health foods in a conventional sense.

The mixed herbal medicine of the present invention can be added directly to the food or can be used together with other food or food ingredients, and can be suitably used according to a conventional method. The amount of the active ingredient to be mixed can be suitably determined according to its use purpose (for prevention or improvement). Generally, the amount of the extract in the health food may be 0.1 to 90 parts by weight of the whole food. However, in the case of long-term intake intended for health and hygiene purposes or for the purpose of controlling health, the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount exceeding the above range.

The health functional beverage composition of the present invention is not particularly limited to the other components other than the ingredients containing the mixed herb as an essential ingredient in the indicated ratios and may contain various flavors or natural carbohydrates as additional ingredients such as ordinary beverages . Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And polysaccharides, for example, conventional sugars such as dextrin, cyclodextrin and the like, and sugar alcohols such as xylitol, sorbitol and erythritol. Natural flavors (tau martin, stevia extracts (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharin, aspartame, etc.) can be advantageously used as flavors other than those described above The ratio of the natural carbohydrate is generally about 1 to 20 g, preferably about 5 to 12 g per 100 ml of the composition of the present invention.

In addition to the above, the mixed medicinal preparation of the present invention can be used as a flavoring agent such as a variety of nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, coloring agents and aging agents (cheese, chocolate etc.), pectic acid and its salts, Salts thereof, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated drinks, and the like. In addition, the herbal medicine of the present invention may contain natural fruit juice and pulp for the production of fruit juice drinks and vegetable drinks. These components may be used independently or in combination. The proportion of such additives is not so critical, but is generally selected in the range of 0.1 to about 20 parts by weight per 100 parts by weight of the mixed medicament of the present invention.

Hereinafter, the present invention will be described in detail with reference to Examples, Experimental Examples and Preparation Examples.

However, the following Examples, Experimental Examples and Preparation Examples are merely illustrative of the present invention, and the present invention is not limited to the following Examples, Experimental Examples and Production Examples.

< Example  1 > Preparation of pharmaceutical composition

Samcheok is the mountain of Yunnan Province in China, Yonggeun in Guangxi Province in China, Ganghwang in Guangxi Province in China, Danshan in Hebei Province in China, black shrub in China, Sanbangum, malt and Uhuam were domestic products and purchased through clean luxury pharmaceutical company .

100 g of corn steep liquor, 100 g of black corn, 100 g of gold in a mortar and weighing 100 g of gold in the system are mixed and added with purified water in an amount of 8 to 10 times that of the herbal medicine, followed by extraction at 100 to 105 ° C for 4 hours. The filtrate is concentrated under reduced pressure at 60 DEG C or lower and dried, and the right bile is separately dried without boiling to obtain a dried product (50 g). These two dried materials were pulverized and then mixed and filled into capsules (Fig. 1). In addition, the composition was prepared as described above, except that malt was used instead of malt, and dansamp was used instead of malic acid, and Dansamp was mixed with other herbal medicines and extracted (Fig. 2).

<1-1> Preparation of pharmaceutical composition 1

Composition 1 having the following ingredient contents was prepared in the same manner as in Example 1.

Ingredient content

300g

Ulgum 200g

<1-2> Preparation of pharmaceutical composition 2

Composition 2 having the following ingredient contents was prepared in the same manner as in Example 1.

Ingredient content

300g

Turmeric 200g

&Lt; 1-3 > Preparation of pharmaceutical composition 3

Composition 3 having the following ingredient contents was prepared in the same manner as in Example 1.

Ingredient content

210g

Curry 145g

Black shaft 145g

&Lt; 1-4 > Preparation of pharmaceutical composition 4

Composition 4 having the following ingredient contents was prepared in the same manner as in Example 1.

Ingredient content

250g

Ulgum 160g

Wuham 90g

&Lt; 1-5 > Preparation of pharmaceutical composition 5

Composition 5 having the following ingredient contents was prepared in the same manner as in Example 1.

Ingredient content

250g

Ulgum 160g

Danshang 90g

<1-6> Preparation of pharmaceutical composition 6

Composition 6 having the following ingredient contents was prepared in the same manner as in Example 1.

Ingredient content

190g

Ulugum 120g

Black axis 120g

Uhdam 70g

<1-7> Preparation of pharmaceutical composition 7

Composition 7 having the following ingredient contents was prepared in the same manner as in Example 1.

Ingredient content

150g

Ulyum 100g

Black axis 100g

Uhdam 50g

100g gold in bed

<1-8> Preparation of Pharmaceutical Composition 8

Composition 8 having the following ingredient contents was prepared in the same manner as in Example 1.

Ingredient content

150g

Ulyum 100g

Black axis 100g

Uhdam 50g

Malt 100g

< Experimental Example  1> With galactosamine  Acute Liver damage  Cause Of the rat  Influence of the composition of the present invention on liver levels

4000 mg of the herbal preparation in powder form prepared in Examples <1-1> to <1-8> was orally administered to each group at 400 mg / kg in 100 ml of physiological saline.

Norwegian male rats (body weight 200 ± 10 g) (purchased from Orient Bio Co., Ltd.) were randomly assigned to groups 10 as follows.

Group 1: normal controls

Group 2: Control

Group 3: Composition of Example < 1-1 > 400 mg / kg group

Group 4: Composition of Example < 1-2 > 400 mg / kg administration group

Group 5: Composition of Example < 1-3 > 400 mg / kg group

Group 6: Composition of Example <1-4> 400 mg / kg group

Group 7: Composition of Example <1-5> 400 mg / kg group

Group 8: Composition of Example < 1-6 > 400 mg / kg group

Group 9: Composition of Example <1-7> 400 mg / kg group

Group 10: Composition of Example <1-8> 400 mg / kg group

In each group except the first group, galactosamine was administered intraperitoneally at a dose of 500 mg / kg on the first day of the experiment, and the composition of the present invention was orally administered to each group in the afternoon for 3 days, (Normal control group) and the second group (control group) were orally administered only with physiological saline at the same dose. On the third day of administration, 8 hours after the last administration, blood samples were collected from the orbital vein of the rat, and the activity of each enzyme was measured using a serum analyzer as shown in the following table.

Effect of lowering the liver level of the composition Experimental group Number of animals GOT (IU / L) GPT (IU / L) ALP (IU / L) t-Bil (mg / dl) Group 1 10 150 ± 8.6 144 ± 9.5 96 ± 2.6 0.21 + 0.04 Group 2 10 1636 ± 32.6 1765 ± 48.2 267 ± 16.9 0.45 ± 0.06 Group 3 10 1233 ± 30.1 1453 ± 42.8 215 ± 18.8 0.41 + 0.04 Group 4 10 1391 ± 47.3 1491 + - 40.3 223 ± 15.5 0.41 + - 0.05 Group 5 10 1059 ± 31.1 1124 ± 36.9 201 ± 16.7 0.39 + 0.04 Group 6 10 923 ± 22.6 967 ± 31.5 170 ± 12.1 0.33 ± 0.06 Group 7 10 953 ± 8.6 981 ± 33.6 181 ± 13.6 0.35 + 0.03 Group 8 10 729 ± 15.6 755 ± 20.2 156 ± 10.8 0.33 + 0.03 Group 9 10 641 ± 23.9 651 ± 22.4 131 ± 11.9 0.28 + 0.04 Group 10 10 652 ± 28.2 674 ± 30.6 135 ± 12.3 0.30 0.03

As shown in Table 1, GOT and GPT were significantly increased in the control group in which acute liver injury was caused by galactosamine, and the difference between the groups was markedly significant (P <0.05). These results suggest that galactosamine causes acute injury to liver in rats.

In addition, in the group to which the composition of Example < 1-1 > was administered, the liver level was remarkably lowered, and in the group administered with the composition of Example < 1-7 & Was decreased.

< Experimental Example  2 > Effect of the present invention on prevention of alcohol-induced liver damage

10 groups were set in the same manner as in Experimental Example 1.

All the experimental groups except for the first and second groups were orally administered the compositions according to their respective amounts instead of physiological saline for 14 days after the start of the test. Then, 4 hours after the administration of the composition of the present invention from the 7th day until the final administration, alcohol was orally administered to all the test groups except the first group at a dose of 6 g / kg. After 24 hours of the final administration, blood was collected from the orbital vein and allowed to stand for about 30 minutes. Serum was separated by centrifugation (4000 rpm, 20 minutes), and triglyceride (TG) and cholesterol CH) was measured according to the free glycerol desorption method as shown in the following table.

Alcohol derivatization of the composition To liver damage  Analysis of Prevention Effectiveness Experimental group Number of animals TG (mg / dL) CH (mg / dL) Group 1 10 21.5 ± 15.2 7.8 ± 3.1 Group 2 10 90.2 ± 12.5 19.45 ± 2.8 Group 3 10 81.6 ± 12.2 15.8 ± 3.0 Group 4 10 82.5 ± 13.1 16.1 ± 2.3 Group 5 10 74 ± 7.2 14.1 ± 2.4 Group 6 10 61 ± 3.3 11.2 ± 1.2 Group 7 10 65 ± 5.7 12.7 ± 3.6 Group 8 10 52 ± 4.4 10.6 ± 0.9 Group 9 10 40 ± 3.1 8.7 ± 0.5 Group 10 10 46 ± 3.2 9.4 ± 0.8

As shown in Table 2, it was found that the composition of the present invention had a preventive effect against alcohol induced liver damage. It was also found that the composition of Example <1-7> or Example <1-8> was more effective than the composition of Example <1-1> or Example <1-2>.

< Experimental Example  3> Effect of the composition of the present invention on chronic hepatitis

In order to examine the effect of the composition of the present invention on hepatitis, a model animal infected with rodent virus (mouse hepatitis virus, MHV) was induced and the following experiment was conducted.

10 groups were set in the same manner as in Experimental Example 1.

In the first group and the second group, distilled water for injection was administered at a dose of 0.1 ml / 10 g. In the remaining experimental group, the suspension was suspended in distilled water for the composition, and the same dose and each dose were orally administered in the morning for 4 weeks. The serum was collected from the orbital vein at 2 weeks after the administration, from the abdominal vein by autopsy after the final administration, and the serum obtained from the centrifuge (4000 rpm, 20 minutes) The following results were obtained.

Analysis of the effect of the composition on chronic hepatitis Experimental group
Number of animals
GOT (IU / L) GPT (IU / L) LDH (IU / L) 2nd week Last day 2nd week Last day 2nd week Last day Group 1 10 144 ± 10.6 152 ± 11.2 160 ± 9.5 180 ± 15.6 151 ± 8.1 152 ± 7.4 Group 2 10 1536 ± 32.6 1580 ± 30.6 1765 ± 48.2 1781 ± 51.1 301 ± 10.7 314 ± 8.2 Group 3 10 1281 ± 33.2 1134 ± 31.5 1453 + - 41.2 1211 + - 44.3 262 ± 8.4 240 ± 5.6 Group 4 10 1292 ± 47.3 1194 + - 40.2 1491 ± 31.3 1255 ± 40.6 281 ± 4.5 269 ± 7.5 Group 5 10 1059 ± 31.1 990 + - 38.2 1124 ± 32.5 1002 ± 33.4 246 ± 4.8 221 ± 6.6 Group 6 10 1023 ± 22.6 941 ± 23.5 962 ± 32.6 951 ± 22.8 232 ± 5.5 212 ± 4.5 Group 7 10 1121 ± 8.6 1005 ± 33.4 985 ± 35.9 1018 ± 33.5 236 ± 4.1 217 ± 5.2 Group 8 10 806 ± 15.6 722 ± 20.1 756 ± 30.1 628 ± 32.8 221 ± 4.4 202 ± 3.3 Group 9 10 596 ± 23.9 452 ± 22.9 641 + - 24.2 489 ± 12.5 185 ± 4.7 161 ± 3.6 Group 10 10 601 ± 28.2 458 ± 21.2 671 ± 32.2 513 ± 23.7 196 ± 4.4 172 ± 3.3

As shown in Table 3, the composition of the present invention markedly lowered liver levels in infection of rats. It was also found that the composition of Example <1-7> or Example <1-8> was more effective than the composition of Example <1-1> or Example <1-2>.

< Experimental Example  4> Patients with hospitalized liver disease of the composition of the present invention 74 cases )

The composition of Example <1-7> was filled into capsules. In addition, this was named as the birth circle, and a clinical trial was performed on 74 patients with hospitalized liver disease (total 74 cases). A total of 184 patients were enrolled in the study. Of these, 184 patients were taking the patient's medication for more than 2 weeks and followed up the LFT for more than 2 weeks after taking the patient's medication. Were analyzed.

<4-1> Comparison of changes in liver function test items 74 cases )

Comparison of changes in liver function test items Corresponding car Probability (both sides) Average Standard Deviation Standard error of mean 95% confidence interval of difference Lower limit maximum Action 1 T_libubin_01 - T_blindubin_f (mg / dL) .11714 .22840 .02730 .06268 .17160 .000 Response 2 ALP_01 - ALP_f (IU / L) 4.18571 30.96993 3.70161 -3.19880 11.57023 .262 Response 3 AST_01 - AST_f (IU / L) 21.24189 35.99243 4.18404 12.90312 29.58066 .000 Response 4 ALT_01 - ALT_f (IU / L) 34.32838 58.63948 6.81670 20.74271 47.91404 .000 Response 5 r_GTP_01 - r_GTP_f (IU / L) 44.16667 65.81965 9.50025 25.05463 63.27870 .000

In Table 4, 01 is a numerical value of the first poetic point (before drug administration), and f is a value at the time of the last liver function test. Thus indicating how much the liver has decreased.

As shown in Table 4, it was found that the total bilirubin, AST, ALT and GTP were significantly decreased in the live birth cohort.

Test for change in response to liver function test items Average N Standard Deviation Standard error of mean T_bilirubin_01 (mg / dL) .7600 70 .28711 .03432 T_libulin_f (mg / dL) .6429 70 .22878 .02734 ALP_01 (IU / L) 140.5429 70 75.53286 9.02790 ALP_f (IU / L) 136.3571 70 75.65316 9.04228 AST_01 (IU / L) 55.4959 74 37.58574 4.36925 AST_f (IU / L) 34.2541 74 16.73113 1.94495 ALT_01 (IU / L) 94.3149 74 75.28559 8.75177 ALT_f (IU / L) 59.9865 74 41.03185 4.76986 r_GTP_01 (IU / L) 120.88 48 98.527 14.221 r_GTP_f (IU / L) 76.7083 48 49.54343 7.15098

In Table 4, 01 is a numerical value of the first poetic point (before drug administration), and f is a value at the time of the last liver function test.

As shown in Table 5, it was found that the total bilirubin, AST, ALT and GTP were significantly decreased in the live birth cohort.

<4-2> Comparison according to liver function classification 74 cases )

From the initial to final analysis of the liver function, it was analyzed how many patients had liver function improved.

Analysis of liver function (final) improvement in liver function (first) Liver function (final) all normal LFT abnormal LFT Liver Injury Liver function (first) normal LFT frequency 3 0 0 3 all % 4.1% .0% .0% 4.1% abnormal LFT frequency 14 15 5 34 all % 18.9% 20.3% 6.8% 45.9% Liver Injury frequency 11 12 14 37 all % 14.9% 16.2% 18.9% 50.0% all frequency 28 27 19 74 all % 37.8% 36.5% 25.7% 100.0%

As can be seen from Table 6, it was confirmed that the frequency tends to increase in a direction in which the liver function is improved overall.

Liver function (initial) to liver function (final) improvement Chi squared  black value Degree of freedom Likelihood of asymptotic significance (two-sided test) Pearson Chi Square 10.106 ^a 4 .039 Udo Bun 11.048 4 .026 Linear vs. linear combination 6.701 One .010 Effective cases 74

a. 3 cells (33.3%) are cells with an expected frequency less than 5; The minimum expected frequency is .77.

As a result, it can be seen that the herbal composition according to the present invention can effectively prevent and treat liver disease, as can be seen from animal tests and clinical test results.

Hereinafter, the medicament comprising the composition of the present invention was prepared as follows.

< Manufacturing example  1> Preparation of pharmaceutical preparations

<1-1> Sanje  Produce

20 mg of the composition of Example < 1-7 >

20 mg of lactose

After mixing the above components, the mixture was packed in an airtight container to prepare a powder.

<1-2> Preparation of tablets

10 mg of the composition of Example < 1-7 >

Corn starch 100 mg

100 mg of milk

2 mg of magnesium stearate

After mixing the above components, tablets were prepared by tableting according to a conventional method for producing tablets.

&Lt; 1-3 > Preparation of capsules

10 mg of the composition of Example < 1-7 >

3 mg of crystalline cellulose

Lactose 14.8 mg

Magnesium stearate 0.2 mg

After mixing the above components, the capsules were filled in gelatin capsules according to the conventional preparation method of capsules.

<1-4> Liquid  Produce

20 mg of the composition of Example < 1-7 >

10 g per isomer

5 g mannitol

Purified water quantity

Each component was added to purified water in accordance with the usual liquid preparation method and dissolved, and the lemon flavor was added in an appropriate amount. Then, the above components were mixed, and purified water was added thereto. The whole was adjusted to 100 ml with purified water, And sterilized to prepare a liquid preparation.

<1-5> Preparation of Injection

The composition of Example < 1-7 > 10 μg / ml

Diluted hydrochloric acid BP until pH 7.6

Sodium chloride up to 1 ml for injection

The composition of the present invention was dissolved in a suitable volume of sodium chloride BP and the pH of the resulting solution was adjusted to pH 7.6 with diluted hydrochloric acid BP and the volume was adjusted using broth sodium chloride BP and mixed thoroughly. The solution was filled in 5 ml type I ampoule made of transparent glass, sealed in the upper lattice of the air by dissolving the glass, and sterilized by autoclave at 120 캜 for 15 minutes or longer to prepare an injection solution.

< Manufacturing example  2> Manufacturing of food

Foods comprising the composition of the present invention were prepared as follows.

<2-1> Production of flour food

0.5 to 5.0 parts by weight of the composition of Example < 1-7 > was added to wheat flour, and bread, cake, cookies, crackers and noodles were prepared by using the mixture to prepare health improving foods.

<2-2> Dairy products ( dairy products )

5-10 parts by weight of the composition of Example <1-7> was added to milk, and various dairy products such as butter and ice cream were prepared using the milk.

<2-3> Solar  Produce

Brown rice, barley, glutinous rice, and yulmu were dried by a known method and dried, and the mixture was granulated to a powder having a particle size of 60 mesh.

Black soybeans, black sesame seeds, and perilla seeds were steamed and dried by a conventional method, and then they were prepared into powder having a particle size of 60 mesh by a pulverizer.

The composition of Example <1-7> was concentrated under reduced pressure in a vacuum concentrator, sprayed and dried with a hot-air drier, and the resulting dried product was pulverized to a particle size of 60 mesh with a pulverizer to obtain a dry powder.

The grains, seeds, and dry powder of the composition of Example <1-7> prepared above were blended in the following proportions.

(30 parts by weight of brown rice, 15 parts by weight of yulmu, 20 parts by weight of barley)

Seeds (7 parts by weight of perilla, 8 parts by weight of black beans, 7 parts by weight of black sesame seeds)

The composition (3 parts by weight) of Example <1-7>,

(0.5 parts by weight), and

Rhubarb (0.5 parts by weight).

<2-4> Production of health supplement

100 mg of the composition of Example <1-7>

Vitamin mixture quantity

70 [mu] g of vitamin A acetate

Vitamin E 1.0 mg

0.13 mg vitamin B1

0.15 mg of vitamin B2

0.5 mg vitamin B6

0.2 [mu] g vitamin B12

10 mg vitamin C

Biotin 10 μg

Nicotinic acid amide 1.7 mg

50 ㎍ of folic acid

Calcium pantothenate 0.5 mg

Mineral mixture quantity

1.75 mg of ferrous sulfate

0.82 mg of zinc oxide

Magnesium carbonate 25.3 mg

15 mg of potassium phosphate monobasic

Secondary calcium phosphate 55 mg

Potassium citrate 90 mg

100 mg of calcium carbonate

24.8 mg of magnesium chloride

Although the composition ratio of the above-mentioned vitamin and mineral mixture is comparatively mixed with a composition suitable for health food as a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional method for producing healthy foods , Granules can be prepared and used in the manufacture of health food compositions according to conventional methods.

< Manufacturing example  3> Health drink  Produce

       100 mg of the composition of Example <1-7>

       Citric acid 100 mg

       100 mg of oligosaccharide

       2 mg of plum concentrate

       100 mg taurine

       Purified water was added to 500 ml

The above components were mixed according to a conventional health drink manufacturing method, and the mixture was heated at 85 DEG C for about 1 hour with stirring, and the resulting solution was filtered to obtain a sterilized 1 liter container, sealed sterilized, It is used in the production of the health beverage composition of the invention.

Although the composition ratio is a mixture of the components suitable for the preferred beverage as a preferred embodiment, the blending ratio may be arbitrarily varied according to the regional and national preferences such as the demand level, the demanding country, and the intended use.

It will be apparent to those skilled in the art that various modifications and variations can be made by those skilled in the art without departing from the scope of the present invention as set forth in the appended claims. .

Claims (15)

delete Which comprises 20 to 40 parts by weight of corn steep liquor and 15 to 25 parts by weight of corn as an active ingredient and further containing 15 to 25 parts by weight of a black shade ( Pharbitis nil ) or 5 to 10 parts by weight of Bos taurus var Domesticus A pharmaceutical composition for preventing and treating liver damage and hepatitis.
Acute liver injury and / or an acute liver injury comprising 20 to 40 parts by weight of corn steep liquor, 15 to 25 parts by weight of corn, 15 to 25 parts by weight of black shale, 5 to 15 parts by weight of humus, and 15 to 25 parts by weight of intra- A pharmaceutical composition for the prevention and treatment of hepatitis.
delete delete The pharmaceutical composition for preventing and treating acute liver injury and hepatitis according to claim 2 or 3, wherein the mutant is replaced with Salvia miltiorrhiza Bunge .
The pharmaceutical composition for preventing and treating acute liver injury and hepatitis according to claim 3, wherein the in-situ gold is substituted with malt ( Hordeum vulgare Linne ).
The pharmaceutical composition of claim 3,
(1) mixing 20 to 40 parts by weight of gum roots, 15 to 25 parts by weight of gilt, 15 to 25 parts by weight of a black shaft, and 15 to 25 parts by weight of gold in situ;
(2) extracting the mixture of step (1) with hot water to prepare an extract;
(3) concentrating and drying the extract of step (2);
(4) drying 5 to 15 parts by weight of the bile without boiling;
(5) pulverizing and then mixing the dried product of step (3) and the dried product of step (4).
delete Which comprises 20 to 40 parts by weight of corn steep liquor and 15 to 25 parts by weight of corn as an active ingredient and further containing 15 to 25 parts by weight of a black shade ( Pharbitis nil ) or 5 to 10 parts by weight of Bos taurus var Domesticus Health food for preventing and improving liver damage and hepatitis.
Acute liver injury and / or an acute liver injury comprising 20 to 40 parts by weight of corn steep liquor, 15 to 25 parts by weight of corn, 15 to 25 parts by weight of black shale, 5 to 15 parts by weight of humus, and 15 to 25 parts by weight of intra- Health food for prevention and improvement of hepatitis.
delete delete 12. The health food for preventing and ameliorating acute liver injury and hepatitis according to claim 10 or 11, wherein said false-positive is replaced by fresh ginseng.
12. The health food for preventing and ameliorating acute liver injury and hepatitis according to claim 11, wherein the in-situ gold is substituted with malt.

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