KR102494072B1 - Composition for improving or preventing depression comprising herbal extracts and method for preparing thereof - Google Patents

Abstract

The present invention relates to a composition for improving or preventing depression comprising a herbal medicine extract and a producing method therefor, wherein according to the present invention, with less burden on the body, the present invention, at the same time, has an advantage of exhibiting a sufficient depression relieve effect. Therefore, embodiments of the present invention provide an effect of improving or preventing depression. The present invention comprises a ginseng root extract, a polygonum multiflorum root extract, a Taraxacum platycarpum whole plant extract, and a desert cistanche stem extract as active ingredients.

Description

Composition for improving or preventing depression containing crude drug extract and method for preparing the same

The following examples relate to a composition for improving or preventing depression containing a herbal extract and a method for preparing the same.

Depression is a common mental illness, also called a cold of the mind, which can cause poor interpersonal relationships and, in severe cases, can lead to serious consequences such as suicide. Fortunately, depression is a disease that can be effectively treated, and the initial recovery rate is 70-80% within 2 months. Counseling and psychiatric treatment are essential for depression, and antidepressant administration is also necessary for moderate or severe depression. In particular, recently developed antidepressants improve depressive symptoms by increasing serotonin in the brain, and can safely improve depression with little side effects. There are various causes of depression, but among them, if there is a biological cause, it is due to an imbalance of neurotransmitters in the brain. Examples of typical neurotransmitters include histamine, serotonin, and dopamine. It is commonly known that a decrease in the neurotransmitter in the brain called serotonin is highly related to depression. In addition, life and environmental stress can be the cause. Stress such as the death of a loved one, separation, loneliness, job loss, and financial worries can cause or worsen depression, and it can be caused by physical illness or drugs. . For example, various diseases such as cancer, endocrine system disease, sudden consciousness disorder caused by cerebral blood circulation disorder, and stroke accompanied by motor paralysis can cause depression. In order to relieve this feeling of depression, as in Korean Patent Registration No. 10-1282759, a food containing Seonokbacterium and herbal ingredients as main components was developed. However, the effect of relieving depression is still not so great. In addition, in the case of drinks containing some herbal medicines, whether or not they are harmful to the human body is controversial. Therefore, it is necessary to develop a composition that exerts a sufficient effect of relieving depression while burdening the human body at the same time.

Republic of Korea Patent Registration No. 10-1282759

The following examples have been made to solve the above problems, and an object of the present invention is to provide a composition and a method for preparing the same, which exert a sufficient depressive effect while burdening the human body at the same time.

In order to achieve the above object of the present invention, one embodiment of the present invention provides a food composition for improving or preventing depression, including ginseng extract, jeokshu extract, pogongyoung extract and yukjongyong extract as active ingredients.

One embodiment of the present invention comprises the steps of preparing a first extract by extracting ginseng, jeokshuo and yukjongyong; preparing a second extract by mixing Pogongyoung with the first extract and then extracting; It provides a method for preparing a food composition for improving or preventing depression, including a method comprising; and preparing a powder by drying the second extract.

According to the present invention, there is an advantage in exerting a sufficient depressive effect while burdening the human body at the same time. Accordingly, embodiments of the present invention provide an effect of improving or preventing depression.

Hereinafter, embodiments will be described in detail with reference to the accompanying drawings. However, since various changes can be made to the embodiments, the scope of the patent application is not limited or limited by these embodiments. It should be understood that all changes, equivalents or substitutes to the embodiments are included within the scope of rights.

Specific structural or functional descriptions of the embodiments are disclosed for illustrative purposes only, and may be modified and implemented in various forms. Therefore, the embodiments are not limited to the specific disclosed form, and the scope of the present specification includes changes, equivalents, or substitutes included in the technical spirit.

Although terms such as first or second may be used to describe various components, such terms should only be construed for the purpose of distinguishing one component from another. For example, a first element may be termed a second element, and similarly, a second element may be termed a first element.

When an element is referred to as being “connected” to another element, it should be understood that although it may be directly connected or connected to the other element, other elements may exist in the middle.

Terms used in the examples are used only for descriptive purposes and should not be construed as limiting. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as “include” or “have” are intended to designate that there is a feature, number, step, operation, component, part, or combination thereof described in the specification, but one or more other features It should be understood that the presence or addition of numbers, steps, operations, components, parts, or combinations thereof is not precluded.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by a person of ordinary skill in the art to which the embodiment belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related art, and unless explicitly defined in the present application, they should not be interpreted in an ideal or excessively formal meaning. don't

Advantages and features of the present invention, and methods of achieving them, will become clear with reference to the detailed description of the following embodiments taken in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in various different forms, only these embodiments make the disclosure of the present invention complete, and common knowledge in the art to which the present invention belongs. It is provided to fully inform the holder of the scope of the invention, and the present invention is only defined by the scope of the claims.

In the embodiments of the present invention, unless otherwise defined, all terms used herein, including technical or scientific terms, are the same as those commonly understood by one of ordinary skill in the art to which the present invention belongs. It has meaning. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related art, and unless explicitly defined in the embodiments of the present invention, an ideal or excessively formal meaning not be interpreted as

The shapes, sizes, ratios, angles, numbers, etc. disclosed in the drawings for explaining the embodiments of the present invention are illustrative, so the present invention is not limited to the details shown. In addition, in describing the present invention, if it is determined that a detailed description of related known technologies may unnecessarily obscure the subject matter of the present invention, the detailed description will be omitted. When 'includes', 'has', 'consists of', etc. mentioned in this specification is used, other parts may be added unless 'only' is used. In the case where a component is expressed in the singular, the case including the plural is included unless otherwise explicitly stated.

In interpreting the components, even if there is no separate explicit description, it is interpreted as including the error range.

The size and thickness of each component shown in the drawings are shown for convenience of description, and the present invention is not necessarily limited to the size and thickness of the illustrated components.

Each feature of the various embodiments of the present invention can be partially or entirely combined or combined with each other, and as those skilled in the art can fully understand, various interlocking and driving operations are possible, and each embodiment can be implemented independently of each other. It may be possible to implement together in an association relationship.

Hereinafter, the present invention will be described in detail with reference to examples and drawings. However, it is apparent that the present invention is not limited by the following examples and drawings.

Food composition for improving or preventing depression

In one aspect, the present invention provides a food composition for improving or preventing depression, including ginseng extract, jeokshu extract, pogongyoung extract and yukjongyong extract as active ingredients.

In particular, the inventors of the present invention found that when a combination of the above ingredients is included in the composition as an active ingredient, it is less burdensome to the human body, has no side effects because they are all herbal medicines, can be consumed regardless of gender and age, and at the same time exerts a sufficient effect of relieving depression. was completed, and a method of approaching the relief of depression from a medical point of view was found by applying safe substances approved as food. The composition of the present invention can be used to improve or prevent depression.

In the present invention, the term "extract" means an active ingredient separated from a natural product, and can be obtained by an extraction process using water, an organic solvent, or a mixed solvent thereof, and an extract, a dry powder thereof, or a mixture thereof. It includes all forms formulated by The extracted liquid can be used directly or concentrated and/or dried to be used as a “powder”. For extraction using organic solvents, methanol, ethanol, isopropanol, butanol, ethylene, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, dichloromethane, N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), 1,3-butylene glycol, propylene glycol, or a mixed solvent of these organic solvents are used, and the active ingredients can be extracted at room temperature or heated under conditions that are not destroyed or minimized. Depending on the organic solvent to be extracted, the degree of extraction and loss of the active ingredient of the medicinal material may differ, so select and use an appropriate organic solvent. The extraction method is not particularly limited, and examples thereof include hot water extraction, cold needle extraction, ultrasonic extraction and reflux extraction.

The solvent extract may further comprise filtering the extract to remove suspended solid particles. Particles may be filtered out using cotton, nylon, or the like, or ultrafiltration, cryofiltration, centrifugation, or the like may be used, but is not limited thereto. In the case of concentrating the extract, methods such as vacuum concentration and reverse osmosis concentration may be used. The drying step after concentration includes, but is not limited to, freeze drying, vacuum drying, hot air drying, spray drying, reduced pressure drying, foam drying, high frequency drying, infrared drying, and the like.

The feeling of depression may be a feeling of depression caused by stress. Stress refers to a state of physical or psychological pressure, which is caused by factors prevalent in daily life. The cause of the depression may be a genetic factor or may be caused by a drug.

The "prevention" means any action to suppress or delay the disease by administration of the composition. The foregoing improvement” refers to all actions that at least reduce the parameters related to the condition, eg, the severity of symptoms.

The above-mentioned ginseng (人蔘, Panax ginseng CA Mey. 1909)” is a perennial plant belonging to the Aralia family, and its roots are used for medicinal purposes, and it is known to protect the five organs and replenish vitality, and has been called a great medicine for longevity since ancient times. The efficacy of medicinal components of ginseng began to be revealed as a study on ginsenoside or saponin by Brekhman (1957). Ginsenosides are known to have many effects such as cancer cell proliferation inhibitory effect, improvement of hypertension, antioxidant effect, and anti-stress. According to the herbal medicine, ginseng has the effect of boosting energy, strengthening the lungs, improving the spleen, and relaxing the heart.

The "jeokhasuo (赤何首烏)" is a creeping perennial plant that has no hairs throughout the plant. The roots extend into the ground and form round tuberous roots. Leaves are alternate, ovate heart-shaped, 3-6cm long, with petioles, flat edges, stipules are short cylindrical. White flowers bloom in August-September, and they run on panicles running in racemes at the ends of branches, and 5 calyxes grow after flowers bloom. There are 8 stamens, ovaries are ovoid, and styles are 3. Fruits have achene, wings, and triangular ovate. Cultivated or grown wild in various parts of Korea, it is distributed in Japan, the north of central China, and Sichuan and Yunnan in the west. Often, only the roots of sewage are referred to as red sewage. The tuberous root is used medicinally for tonic, hair loss, and depression. Also called red goose. According to the Herbal Medicine, the dripping water treats lymphadenitis and soothes boils, so it heals pimples on the head and face, stops hemorrhoids and heartache, boosts blood, blackens hair, and improves complexion. It has an effect.

The above "pogongyeong (蒲公英)" refers to dried herbs of dandelion or plants of the same genus. The root of Pogongyeong is fleshy, conical, dark brown, 4-7 cm long, and wrinkled on the surface. Leaves face each other, have petioles, sawtooth on leaves, and 3 distinct veins. Pogongyoung contains components such as flavonoids, phenolic compounds, coumarin, and sterols. Pogongyoung is a medicine that relieves heat poisoning and removes boils. It is used for swelling, mastitis, sore throat, carbuncle (appendicitis, lung abscess, peritonitis), and is used for eye congestion, acute hepatitis, jaundice, and inability to urinate due to heat. As for the pharmacological action, antibacterial action, immune function enhancement, bile secretion action, liver function protection action, and diuretic action have been reported. According to Bonchogangmok, Pogongyoung has the effect of darkening the hair and strengthening the stomach and bones.

The “Yukjongyong (肉)” is a medicinal material made using the fleshy scape of a perennial parasitic plant of the family Yeoldangaceae or other related plants of the same genus. Yukjongyong is used for constipation caused by dry intestines, low back pain due to lack of kidney, weak and helpless symptoms of legs, tinnitus, forgetfulness, well-being, Yuno, infertility, colic, lower abdominal cold, major bleeding, sweating, and constipation. In addition, pharmacological actions such as lowering blood pressure, promoting salivary secretion, and improving respiratory paralysis have been reported. According to the herbal medicine, yukjongyong has the effect of lubricating the intestines, treating constipation, strengthening bones, and supplementing the amount.

In one embodiment, the ginseng extract is a ginseng root extract, the droplet rhizome extract is a root extract, and the pogongyoung extract is a pogongyeonge whole plant extract.

In one embodiment, in the food composition, the ginseng extract is contained in an amount of 15 to 30% by weight based on the total weight of the composition, and the red rhubarb extract is contained in an amount of 20 to 40% by weight based on the total weight of the composition. The pogongyoung extract is contained in an amount of 25 to 45% by weight based on the total weight of the composition, and the yukjongyong extract is contained in an amount of 5 to 20% by weight based on the total weight of the composition.

More specifically, the ginseng extract is 15% by weight or more, 16% by weight or more, 17% by weight or more, 18% by weight or more, 19% by weight or more, 20% by weight or more, 21% by weight or more, 22% by weight or more based on the total weight of the composition. 23% or more, 24% or more, 25% or more; 30 wt% or less, 29 wt% or less, 28 wt% or less, 27 wt% or less, 26 wt% or less, 25 wt% or less.

More specifically, the water chestnut extract is 20% by weight or more, 25% by weight or more, 30% by weight or more based on the total weight of the composition; It is contained in an amount of 40% by weight or less, 35% by weight or less, and 30% by weight or less.

More specifically, the pogongyoung extract is 25% by weight or more, 26% by weight or more, 27% by weight or more, 28% by weight or more, 29% by weight or more, 30% by weight or more based on the total weight of the composition; 45% by weight or less, 40% by weight or less, 35% by weight or less, 30% by weight or less.

More specifically, the yukjongyong extract is 5% by weight or more, 6% by weight or more, 7% by weight or more, 8% by weight or more, 9% by weight or more, 10% by weight or more based on the total weight of the composition; 20% or less, 19% or less, 18% or less, 17% or less, 16% or less, 15% or less, 14% or less, 13% or less, 12% or less, 11% or less, It is contained in an amount of 10% by weight or less.

In one embodiment, in the food composition, the content ratio of the ginseng extract, Jeokshu extract, Pogongyoung extract, and Yukjongyong extract is 0.75 to 6: 1 to 8: 1.25 to 9: 1 based on weight. Alternatively, the content ratio is 2 to 4:2.5 to 5:3 to 5:1 by weight. Alternatively, the content ratio is 2.5: 3: 3.5: 1 based on weight.

According to one embodiment of the present disclosure, the composition is a health functional food composition. In one embodiment, by including the food composition can be prepared as a health functional food consisting of any one of powder, granule, pill, tablet, capsule or beverage form. The manufacturing method may use a baking method or a far infrared ray method, but is not limited thereto.

The above “health functional food” refers to food manufactured and processed by extracting, concentrating, refining, mixing, etc. specific ingredients as raw materials or specific ingredients contained in raw materials for the purpose of health supplement, and by the above ingredients It refers to food designed and processed to fully exert bioregulatory functions, such as defense, against the living body, and means that it can perform functions related to disease prevention, improvement, or recovery of health.

There is no particular limitation on the type of health functional food in which the extracts according to the present disclosure can be used. For example, ramen, other noodles, beverages, tea, drinks, alcoholic beverages, various soups, meat, sausages, bread, chocolate, candy, confectionery, pizza, chewing gum, dairy products including ice cream, or vitamin complexes. In addition, the health functional food includes a form of powder, granule, tablet, capsule or beverage, preferably a beverage form. In addition, when using the extract according to the present disclosure as a health functional food, it may be added as it is or used together with other foods or food ingredients, which may be selected and used appropriately as needed. In addition, in addition to the extracts according to the present disclosure, it is possible to mix appropriate auxiliary components and known additives that may be commonly contained in health functional foods according to the selection of a person skilled in the art.

Method for manufacturing food composition for improving or preventing depression

In another aspect, the present invention comprises the steps of preparing a first extract by extracting ginseng, jeokshuo and yukjongyong; preparing a second extract by mixing Pogongyoung with the first extract and then extracting; It provides a method for preparing a food composition for improving or preventing depression, including a method comprising; and preparing a powder by drying the second extract.

In the manufacturing method according to one embodiment of the present invention, the extraction may be performed by pulverizing the freeze-dried raw material and then adding distilled water to extract at 75 to 85 ° C. for 2 to 4 hours. Preferably, distilled water is added to the freeze-dried raw material. The extraction can be repeated three times for 3 hours at 80 ° C.

{Example}

Hereinafter, the present disclosure will be described in detail by examples. However, the following examples are only examples for helping the overall understanding of the present disclosure, and the content of the present disclosure is not limited to the following examples.

<Preparation Example 1> Preparation of a food composition for improving or preventing depression

After drying and pulverizing 60 g of ginseng root, 30 g of red rhubarb root, and 20 g of stem for breeding, 1.2 L of 70% ethanol solution (ethanol diluted with distilled water) was added as an extraction solvent and incubated at 50 ° C to 60 ° C for 4 hours. Heat extraction was performed while preparing a first extract. Subsequently, 20 g of Pogongyoung whole plant was dried and pulverized, mixed with the first extract, distilled water was added as an extraction solvent, and extracted at 80 ° C. for 30 minutes to prepare a second extract. Subsequently, the second extract was lyophilized and finely ground in a completely dry form to prepare granules, dried at the temperature of 60 ° C to 65 ° C for 5 hours, and then a powder of 100 mesh was prepared. Then, 100 g of the powder was mixed with 100 g of glutinous rice and 200 mL of purified water to prepare a pill with a diameter of 4 mm. The composition of the prepared pills is shown in Table 1 below.

Classification (unit: % by weight) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Ginseng Extract 23 20 20 23 23 23 10 23 red bell pepper extract 8 8 12 0 8 8 8 20 pogongyoung extract 7 7 7 7 0 7 7 7 yukjongyong extract 7 7 7 7 7 0 7 7

<Experimental Example 1> Experiment to confirm the effect of relieving depression

In order to confirm the depression relieving effect of the composition for improving or preventing depression containing the herbal extract of the present invention as an active ingredient, 40 men and women in their 10s to 40s (10 people for each age group) who usually have depressive symptoms were tested in the Example. The prepared pills were taken 10 pills at a time, twice a day, for 4 weeks (28 days). The degree of relief was evaluated on the basis of 5 points for depressive symptoms before taking the pills prepared in Examples, and the average values are shown in Table 2 below (5 points: no change, 4 points: slightly relieved, 3 points: somewhat resolution, 2 points: moderate resolution, 1 point: complete resolution).

Classification (after 28 days) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 teenager 2.1 2.5 2.4 3.7 3.6 3.8 3.5 3.8 20's 2.4 2.7 2.9 3.9 4.2 4.0 3.5 3.5 30's 3.1 3.4 3.2 4.1 4.3 4.1 4.2 4.0 40's 3.2 3.5 3.3 4.2 4.3 4.0 4.1 3.7

From Table 2, it can be seen that the effect of relieving depression is excellent when the active ingredients of the composition according to the present invention are included in a preferred content range.

<Formulation Example 1> Preparation of Pills

Pills were prepared in a conventional manner according to the compositions shown in Table 3 below.

ingredient Content (unit: % by weight) Ginseng Extract 23 red bell pepper extract 8 pogongyoung extract 7 yukjongyong extract 7 glycerin Appropriate amount sorbitol powder Appropriate amount

<Formulation Example 2> Manufacture of Drinking Agent

According to the composition shown in Table 4 below, a drink was prepared by a conventional method.

ingredient Content (unit: % by weight) Ginseng Extract 23 red bell pepper extract 8 pogongyoung extract 7 yukjongyong extract 7 citric acid Appropriate amount citric acid Appropriate amount

Although the present invention has been described with respect to the preferred embodiments mentioned above, various modifications and variations are possible without departing from the spirit and scope of the invention. Accordingly, the scope of the appended claims will include such modifications and variations insofar as they fall within the scope of the present invention.

Claims (3)

It contains ginseng root extract, rhizome root extract, pogongyoung whole plant extract, and yukjongyong stem extract as active ingredients,
The ginseng root extract is contained in an amount of 20 to 25% by weight based on the total weight of the composition,
The water chestnut root extract is contained in an amount of 5 to 15% by weight based on the total weight of the composition,
The pogongyeong root extract is contained in an amount of 5 to 10% by weight based on the total weight of the composition,
The yukjongyong stem extract is contained in an amount of 5 to 10% by weight based on the total weight of the composition, a food composition for improving or preventing depression. delete delete