KR20110075593A - Antibiotic functional food containing extract of platycodon grandiflorum and garlic for preventing and improving respiratory organ disease - Google Patents

Abstract

PURPOSE: A health functional food composition for curing and preventing respiratory disease is provided to use a platycodon grandiflorum extract and a garlic extract. CONSTITUTION: A health functional food composition for curing and preventing respiratory disease is produced by the following steps: naturally aging platycodon grandiflorum and garlic; adding hard boiled glutinous rice, starch syrup, and water into the aged platycodon grandiflorum and garlic for saccharifying; filtering the saccharified extract, and concentrating the filtrate; and adding one extract obtained from an ingredient selected from ginseng, radish, lycium chinense, or zanthoxylum piperitum into the concentrate.

Description

Antibiotic functional food containing extract of Platycodon grandiflorum and garlic for preventing and improving respiratory organ disease}

The present invention relates to a health functional food composition for the prevention and improvement of respiratory diseases containing bellflower and garlic extract, more specifically ginseng, radish containing a bellflower and garlic mixed extract as an active ingredient and other trace herbal ingredients Health functional foods for the prevention and improvement of respiratory diseases containing bellflower and garlic extracts, which can prevent and improve symptoms of respiratory diseases such as asthma, bronchitis, and sore throat by further mixing one or more extracts selected from goji and goji It relates to a composition.

Recently, due to the development of the industrial economy, respiratory diseases are rapidly increasing due to environmental pollution and changes in diet. Asthma, a typical respiratory disease, is a condition in which respiratory distress, coughing, and colorful, rough breathing (wheezing) occur repeatedly and seizure. However, in fact, asthma patients often complain of atypical symptoms in addition to the typical symptoms of asthma. In other words, if there are no symptoms such as shortness of breath or wheezing, only a dry cough appears repeatedly, complains of chest tightness, chest tightness or sputum in the throat. .

Bronchitis is divided into acute and chronic. Chronic cough, sputum and dyspnea are the main symptoms. Sputum is usually white or slightly yellowish mucus and tends to appear a lot in the morning. As the disease progresses, respiratory distress gradually develops over several months and years, resulting in difficulty in breathing even with a slight activity. The causes are allergic, infectious, traumatic and the like, and pathologically catarrhal, purulent, ulcerative and invasive. The most common cause is infection by bacteria, viruses, fungi, and the like, and people who are not normally infected are susceptible to infection when the resistance of the whole body is weakened.

Allergic rhinitis is also referred to as nasal allergy or allergic rhinitis, symptoms of sudden sneezing, watery nasal juice (clear runny nose), large amounts of nasal congestion, and heavy head and tears. The symptoms are very similar, but the antigen is not clear is called vasomotor rhinitis. In other words, when one wakes up in the morning and the body cools down temporarily, the symptoms mentioned above may occur and heal in a few hours. It is often confused with a cold, which is different from the common cold and often involves asthma or hives.

As mentioned above, respiratory diseases such as asthma, chronic bronchitis, and allergic rhinitis have some differences in their causes and symptoms, and new drug development is developing depending on the respiratory diseases, but the symptoms are temporary. Deterioration is exacerbating the problem.

In order to solve this problem with 100% natural ingredients in order to eliminate the side effects and resistance of synthetic chemical new drugs, medicinal plants were used to develop a respiratory disease treatment-improving composition. have.

Bellflower (Gilkyung; Platycodon grandiflorum ) is distributed in Korea, China, Japan, and Manchuria. It is a perennial herb belonging to the Campanula, an alkaline food rich in sugar, calcium and iron. Scientific analysis shows that arachnid saponin, which is aromatizing, acts on the respiratory and circulatory organs to help protect the neck and bronchus. Traditional Chinese medicine has been used to stop phlegm and cough. It is used for cough, phlegm, nasal congestion, asthma, bronchitis, sore throat and headache.

Garlic ( Allium sativum L. ) is a perennial plant belonging to the family Liliaceae. The main components of garlic are known as allicin and scordinin. As a substance having a function of promoting fatigue recovery, blood circulation, and metabolism, garlic is a component that has been widely known as a tonic and gangjeong food since ancient times.

Accordingly, the present inventors have steadily studied the effective substances that can prevent and / or improve symptoms of respiratory diseases such as asthma, bronchitis, and sore throat, and have confirmed that bellflower and garlic mixed extracts are effective and completed the present invention.

After all, the main object of the present invention is to provide a dietary supplement for the prevention and improvement of symptoms of respiratory diseases containing bellflower and garlic mixed extract as an active ingredient.

In addition, the present invention is another object to provide a health functional food for the prevention and improvement of symptoms of respiratory diseases containing bellflower and garlic mixed extract as an active ingredient.

In order to achieve the above object, the present invention provides a health functional food composition for the prevention and improvement of respiratory diseases containing bellflower and garlic mixed extract derived from natural products as an active ingredient.

In the present invention, the bellflower and garlic mixed extract, (1) natural ripening bellflower and garlic; (2) saccharifying by mixing glutinous rice, malt and water in the naturally aged bellflower and garlic; And (3) filtering and concentrating the saccharified malt extract. The respiratory disease is asthma, bronchitis, and sore throat. Diseases of any one or more of cough, sputum and migraine.

In addition, to achieve another object of the present invention, the present invention provides a health food for the prevention and improvement of respiratory diseases containing bellflower and garlic mixed extract according to the present invention as an active ingredient.

For reference, this application was performed as a technical support project of Gyeongbuk Marine Bioindustry Research Institute.

The present invention by removing the bitter taste of the bellflower and the spicy taste of garlic and the peculiar smell of bellflower in order to apply the efficacy of bellflower and garlic to the human body, it can be prepared to drink safely without the side effects of synthetic chemical new drugs.

In addition, the present invention may further be added to the mixed extract using bellflower and garlic, and other trace herbal ingredients may be usefully used in the composition for treating respiratory diseases including bronchitis, sore throat and asthma improvement.

Hereinafter, the present invention will be described in detail.

The present invention provides a health functional food composition for the prevention and improvement of respiratory diseases containing bellflower and garlic mixed extract derived from natural products as an active ingredient.

In the present invention, the bellflower and garlic mixed extract, characterized in that it undergoes a aging step to remove the unique bitter taste of bellflower and garlic. The aging step is to wash the bellflower and garlic well to remove water, put each in a steamer 1 to 20 days, preferably 7 to 15 days in the temperature range of about 50 to 80 ℃, preferably 60 to 70 ℃ It is preferable to produce black bellflower, black garlic by natural aging for about 6 to 24 hours, preferably 10 to 20 hours at 80 to 100 ℃ using a hot air dryer.

In addition, the black bellflower and black garlic prepared as described above may be mixed with glutinous rice, malt and water, saccharified and filtered, and the filtrate may be concentrated to prepare a final extract.

In the present invention, the 'extract' includes all of the extract, purified, diluent, concentrate, and dried.

In addition, the 'respiratory disease' in the present invention includes any one or more diseases of asthma, bronchitis, sore throat, cough, sputum, migraine, and means to prevent, improve or reduce the symptoms of the disease.

The dietary supplement composition of the present invention may further contain at least one selected from ginseng, radish, goji berry and sancho in addition to the above-mentioned bellflower and garlic mixed extract.

At this time, the herbal medicine ingredients are preferably included in the form of an extract, each herbal medicine selected, about 1 to 20 times the weight of the sample, preferably 2 to 10 times the volume of water, lower alcohol of 1 to 4 carbon atoms Or a mixed solvent thereof, preferably water, at about 30 to 100 ° C., preferably at 80 to 100 ° C. for about 0.1 to 48 hours, preferably 0.1 to 24 hours, stirring extraction, hot water extraction, cold extraction, warm extraction, reflux The extract obtained after extraction using an extraction method such as cooling extraction or ultrasonic extraction may be obtained by filtration, concentration under reduced pressure or drying.

Bellflower and garlic mixture extract and herbal medicine extracts according to the present invention can be used safely for long-term administration for the purpose of prevention because there is also almost no problems such as toxicity and side effects because it is extracted from the medicine that has been used as a herbal medicine for a long time.

Foods to which the bellflower and garlic mixture extract and herbal medicine extract of the present invention can be added include, for example, various foods, beverages, gums, teas, vitamin complexes, and health functional foods. It may also be added to food or beverages for the purpose of preventing and improving respiratory diseases.

At this time, the amount of the extract in the food or beverage is generally added to the dietary supplement composition of the present invention 0.01 to 99.99% by weight of the total food weight, the health beverage composition in a ratio of 0.02 to 5g based on 100ml Can be added.

The health functional food of the present invention includes the form of tablets, capsules, pills, liquids, and the like, and the health beverage composition of the present invention contains the bellflower and garlic mixed extracts as essential ingredients in the indicated ratio, There is no limitation and may further contain various flavors or natural carbohydrates, such as ordinary drinks.

Examples of the natural carbohydrates mentioned above include monosaccharides such as glucose, fructose and the like, such as resaccharides such as maltose, sucrose and the like and conventional sugars such as polysaccharides such as dextrin, cyclodextrin and the like; Sugar alcohols such as xylitol, sorbitol, and erythritol. In addition to the above, natural flavors, taumartins, stevia extracts such as rebaudioside A, glycyrrhizin and the like and synthetic flavors, saccharin, aspartame and the like can be advantageously used as flavoring agents.

In addition to the above, the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic and natural flavors, colorants and enhancers (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and salts thereof. , Organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated drinks, and the like. These components may be used independently or in combination, and the proportion of such additives is not so critical but is usually selected in the range of 0 to about 20 parts by weight relative to 100 parts by weight of the composition of the present invention.

Hereinafter, the present invention will be described in more detail with reference to the following examples. It is to be understood by those skilled in the art that these examples are for illustrative purposes only and that the scope of the present invention is not construed as being limited by these examples.

First, the main components and the efficacy or use of various ingredients included in the respiratory disease treatment improving agent composition according to the present invention are shown in Table 1 below.

TABLE 1

Main ingredients and efficacy of raw materials Raw material name chief ingredient Efficacy (use) Bellflower Saponins, proteins, sugars, calcium, vitamins B1, B2, etc. Calm, fever, pain, cough, cough, sputum, hypoglycemic, anticholine garlic Allicin, Scordinin, Calcium, Phosphorus, Iron, Essential Oil, Thiamine, Riboflavin, Ascorbic Acid, Fiber, Protein, etc. Tonic / gangjeong, arteriosclerosis, hypertension, promoting sex hormone secretion, antibacterial, respiratory / heart disease, hookworm, diuresis, etc. Ginseng Glycosides, panacenes, polyacetylene compounds, flavonoids, vitamins, etc. Body function enhancement, cardiac function, blood sugar drop, anemia, chronic bronchitis, diabetes, appetite, etc. radish Dietary Fiber, Vitamin C, Carotene, Iron, Diastases, etc. Liver cancer suppression, cold, relieve, asthma, indigestion, blood Wolfberry Betaine, rutin, arginine, glutamic acid, vitamin B, etc. Nourishing tonic, fatigue recovery, high blood pressure, diuresis, fever, constipation, asthma Sancho Limonine, Citronenal, Beta-Ferrenene, Cineol, Dipentene, etc. Abdominal pain, diarrhea, toothache, asthma, low back pain, insecticide

The data on the material shown in Table 1 is shown with reference to the agreement of bogam, medicinal herbs, herbal papers and the like.

Example 1 Preparation of Bellflower and Garlic Mix Extracts

Put freshly washed five-year-old bellflower and fresh garlic, which had the outer skin and the inner skin removed, into a steamer and aged at 70 ℃ for 10 days to produce black bellflower, black garlic, and then in a hot air dryer maintained at a temperature of 80 ~ 100 ℃. Dried for hours.

The black bellflower and black garlic are mixed with glutinous rice, malt and water, fermented at 65-70 ° C. for 9-10 hours and then saccharified, and the filtrate is concentrated until the solid content is 20%. Bellflower and garlic mixed extracts were prepared.

At this time, black bellflower, black garlic, glutinous rice dumplings, malt and water were added in a weight ratio of 1: 1: 3: 1.5: 7, respectively.

Example 2. Preparation of herbal medicine mixed bellflower and garlic mixture extract and ginseng concentrate

400 g of water was added to 50 g of ginseng, heated in a pressure extractor, maintained at an internal temperature of 100 ° C. for 6 hours, cooled to room temperature, and filtered to obtain a ginseng extract.

The ginseng concentrate was prepared in the same amount as the bellflower and garlic mixture extract of Example 1 to prepare a herbal medicine, but the blending process was carried out at 95 ℃ for 3 hours.

Example 3 Preparation of Herbal Medicine Mixed with Bellflower and Garlic Extracts

The concentrate was prepared by putting 25 kg of radish into the extractor for 3 hours at a high temperature of 80 ° C. At this time, 20 ~ 30% of waste is generated, so the extraction amount is about 70 ~ 80%.

The prepared juice-free concentrate was formulated in the same amount of bellflower and garlic mixed extract, the blending process was performed at 95 ℃ for 3 hours.

Example 4 Preparation of Herbal Medicine Combining Bellflower and Garlic Extracts and Wolfberry Concentrate

3 kg of goji berries were collected, washed with water, dried at room temperature for 5 days to remove moisture, and then chopped or pulverized. 80 g of water was added to 5 L of water, heated at 100 ° C., and boiled. At this time, the boiled extract was repeatedly extracted five times to obtain a goji berry concentrate.

The goji berry concentrate was combined with the bellflower and garlic mixture extract in the same amount, the blending process was carried out at 95 ℃ for 3 hours.

Example 5 Preparation of Herbal Medicine Combining Bellflower and Garlic Extracts and Sancho Concentrate

The Japanese herb was classified into seeds and parts except seeds (roots, stems, branches, leaves, fruit bark), dried, and then crushed. 10 parts by weight of distilled water was added to each crushed product, concentrated under reduced pressure at 100 ° C, and the extract was filtered through a filter paper. The filtrate was filtered under reduced pressure using a rotary vacuum evaporator again, concentrated to 1/10 volume to prepare an acetic acid concentrate, and then blended in the same amount as the bellflower and garlic mixed extract, and the blending process was performed at 95 ° C. for 3 hours. It was.

Experimental Example 1. Sensory Evaluation of Bellflower and Garlic Extracts

Twenty patients with severe respiratory disease aged 15-70 years old were included. The bellflower and garlic extract prepared in Example 1 was ingested for a certain period of time to the test subjects (20 people), and the state of improvement over the intake period was investigated. At this time, each test subject was taken twice a day, and all subjects maintained their existing lifestyle and eating habits during the test period.

As a result of taking 1 week to 1 year, as shown in Table 2 showed a relaxation effect.

TABLE 2

Drinking period Chronic cough Chronic sore throat Chronic bronchitis Chronic asthma flu 1 week A little better A little better A little better No improvement Improvement 2 weeks Improvement Improvement Improvement A little better Perfection 3 weeks Improvement Improvement Perfection A little better Completeness 4 Weeks Perfection Perfection Completeness A little better 2 months Completeness Completeness Improvement 3 months Improvement 4 months Improvement 6 months Perfection 1 year Completeness

(Slightly improved; coughing rate is about 50% less than before use), improvement; coughing rate is about 80% less than before use, complete improvement; coughing rate is about 98% less than before use, relieved: coughing number is 1 No symptoms such as coughing for a week or more)

Experimental Example 2. Sensory evaluation of ginseng and garlic extract added with ginseng concentrate

Twenty patients with severe respiratory disease aged 15-70 years old were included. The herbal medicine mixed with bellflower and garlic extract prepared in Example 1 and ginseng concentrate was ingested for a certain period of time for the test subjects (20), and the state of improvement over the intake period was investigated. At this time, each test subject was taken twice a day, and all subjects maintained their existing lifestyle and eating habits during the test period.

As a result of taking 1 week to 1 year, as shown in Table 3, showed a rapid improvement in chronic cough, chronic asthma.

[Table 3]

Drinking period Chronic cough Chronic sore throat Chronic bronchitis Chronic asthma flu 1 week A little better A little better A little better No improvement Improvement 2 weeks Improvement Improvement Improvement A little better Perfection 3 weeks Perfection Improvement Perfection A little better Completeness 4 Weeks Perfection Perfection Completeness A little better 2 months Completeness Completeness Improvement 3 months Improvement 4 months Perfection 6 months Perfection 1 year Completeness

(Slightly improved; coughing rate is about 50% less than before use), improvement; coughing rate is about 80% less than before use, complete improvement; coughing rate is about 98% less than before use, relieved: coughing number is 1 No symptoms such as coughing for a week or more)

Experimental Example 3. Sensory evaluation of radish extract and radish extract

Twenty patients with severe respiratory disease aged 15-70 years old were included. The herbal medicines mixed with the bellflower and garlic extract prepared in Example 1 and the juice-free concentrate were ingested for a certain period of time for the test subjects (20), and the state of improvement over the intake period was investigated. At this time, each test subject was taken twice a day, and all subjects maintained their existing lifestyle and eating habits during the test period.

As a result of taking 1 week to 1 year, as shown in Table 4 showed a rapid improvement in chronic asthma.

[Table 4]

Drinking period Chronic cough Chronic sore throat Chronic bronchitis Chronic asthma flu 1 week A little better A little better A little better A little better Perfection 2 weeks Improvement Improvement Improvement A little better Completeness 3 weeks Perfection Improvement Perfection A little better 4 Weeks Perfection Perfection Completeness Improvement 2 months Completeness Completeness Improvement 3 months Improvement 4 months Perfection 6 months Perfection 1 year Completeness

(Slightly improved; coughing rate is about 50% less than before use), improvement; coughing rate is about 80% less than before use, complete improvement; coughing rate is about 98% less than before use, relieved: coughing number is 1 No symptoms such as coughing for a week or more)

Experimental Example 4. Sensory evaluation of Goji berries with garlic extract

Twenty patients with severe respiratory disease aged 15-70 years old were included. The herbal medicines mixed with bellflower and garlic extract prepared in Example 1 and goji berry concentrate were ingested for a certain period of time for the test subjects (20), and the state of improvement over the intake period was investigated. At this time, each subject was taken twice a day, and all subjects maintained their existing lifestyle and eating habits during the experiment.

As a result of taking 1 week to 1 year, as shown in Table 5 showed a relaxation effect.

TABLE 5

Drinking period Chronic cough Chronic sore throat Chronic bronchitis Chronic asthma flu 1 week A little better A little better A little better No improvement Improvement 2 weeks Improvement Improvement Improvement A little better Perfection 3 weeks Improvement Perfection Perfection A little better Completeness 4 Weeks Perfection Perfection Completeness A little better 2 months Completeness Completeness Improvement 3 months Improvement 4 months Perfection 6 months Perfection 1 year Completeness

(Slightly improved; coughing rate is about 50% less than before use), improvement; coughing rate is about 80% less than before use, complete improvement; coughing rate is about 98% less than before use, relieved: coughing number is 1 No symptoms such as coughing for a week or more)

Experimental Example 5. Sensory Evaluation of Addition of Sancho Concentrate to Bellflower and Garlic Extracts

Twenty patients with severe respiratory disease aged 15-70 years old were included. The herbal medicines mixed with bellflower and garlic extract prepared in Example 1 and an acidic concentrate were fed to the test subjects (20 persons) for a certain period of time, and the state of improvement over the intake period was investigated. At this time, each test subject was taken twice a day, and all subjects maintained their existing lifestyle and eating habits during the test period.

As a result of taking 1 week to 1 year, as shown in Table 6 showed a relaxation effect.

TABLE 6

Drinking period Chronic cough Chronic sore throat Chronic bronchitis Chronic asthma flu 1 week Improvement Improvement A little better A little better Perfection 2 weeks Improvement Improvement Improvement A little better Completeness 3 weeks Perfection Perfection Perfection A little better 4 Weeks Perfection Perfection Completeness Improvement 2 months Completeness Completeness Improvement 3 months Improvement 4 months Perfection 6 months Perfection 1 year Completeness

(Slightly improved; coughing rate is about 50% less than before use), improvement; coughing rate is about 80% less than before use, complete improvement; coughing rate is about 98% less than before use, relieved: coughing number is 1 No symptoms such as coughing for a week or more)

As described above, specific portions of the contents of the present invention have been described in detail, and for those skilled in the art, these specific techniques are merely preferred embodiments, and the scope of the present invention is not limited thereto. Will be obvious. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (5)

Health functional food composition for the prevention and improvement of respiratory diseases containing bellflower and garlic mixed extract as an active ingredient. The method of claim 1, The bellflower and garlic mixed extract, (1) step of natural ripening bellflower and garlic; (2) saccharifying by mixing glutinous rice, malt and water in the naturally aged bellflower and garlic; And (3) filtering the saccharified malt extract to concentrate the filtrate. 11. The method of claim 1, The health functional food composition is a health functional food composition for the prevention and improvement of respiratory diseases, characterized in that it further comprises one or more extracts selected from ginseng, radish, goji berry and sancho. The method of claim 1, The respiratory disease is a health functional food composition for the prevention and improvement of respiratory diseases, characterized in that any one or more diseases of asthma, bronchitis, sore throat, cough, sputum and migraine. Health functional food for the prevention and improvement of respiratory diseases containing bellflower and garlic mixed extract as an active ingredient.