KR20100094015A - Composition for asthma containing black platycodon and phellinus as effective ingredients - Google Patents

Abstract

PURPOSE: A composition containing Phellinus Linteus extract and Platycodon grandiflorus A. DC. Candolle extract is provided to treat bronchial diseases. CONSTITUTION: A composition for treating asthma contains Platycodon grandiflorus A. DC. Candolle and Phellinus Linteus extract as an active ingredient. The Platycodon grandiflorus A. DC. Candolle is prepared by pre-drying, steaming, and drying 6-15 times. The Phellinus Linteus extract is obtained by pulverizing Phellinus Linteus and adding 15-20 times water. A health food for treating asthma contains the composition for treating asthma.

Description

Composition for asthma containing black Platycodon and Phellinus as effective ingredients}

The present invention relates to a healthy food containing the composition and the same to help improve asthma, containing black bellflower and situation mushroom extract as an active ingredient.

Bellflower (Gilyeong, Platycodon grandiflorus A. DC. Candolle ) is a root of perennial herb belonging to the Campanula, which grows widely in China and Japan, including Korea, and is recently grown as a food and pharmacological health food. This is expanding.

In traditional medicine, bellflower has been used as a medicine to stop phlegm and cough. The bellflower root, which looks like ginseng root, is used in spring or autumn to dry in the sun for edible or medicinal use. The taste is spicy and bitter, especially the taste of arine taste is flat, and it acts on the lungs to stop coughing and eliminate phlegm. Cough, phlegm, nasal congestion, asthma, bronchitis, sore throat, headache, etc.

The major pharmacological component of bellflower was found to be triterpenoid-based saponins, which are effective in reducing phlegm by increasing bronchial secretion. Saponin, which is found only in bellflower, is known to have several pharmacological effects, including sedation, antipyretic, analgesic, antitussive, expectorant, hypoglycemic, improved cholesterol metabolism, anticholinergic, anticancer and gastric acid distribution. It is known to be effective as an expectorant for expectoration, tonsillitis, cough, purulent boil, asthma and pulmonary tuberculosis, and pleurisy, etc., and it is known that it can be used as a medicine instead of expensive ginseng. However, these bellflowers are difficult to store for a long time and should be taken immediately after being harvested, and may give a sense of rejection due to the peculiar smell and the arine taste or the heavy taste of the bellflower itself.

Black bellflower can improve its pharmacological efficacy as its saponin content is increased compared to common bellflower, and its storage ability can be improved by reducing the number of microorganisms in the manufacturing process, and its taste and smell are improved, so it is functional food without any other sweetener. Can be used immediately as a material.

Sichuan mushrooms, also known as Yiyi () in China , belong to the genus Mud mushrooms of pine scale mushrooms, and refers to the woody mud mushroom ( Phellinus Linteus ) in Korea. About 48 species of mud mushrooms have been reported around the world, and in Korea, rusty mud mushrooms ( P.ferrginosus ), dry mud mushrooms ( P.gilsus ), horse mud mushrooms (P.igniarius ), eggplant mud mushrooms ( P.laevigatus ), cherry mud mushrooms (P.pomaceus), scratching the mud buggy Pop tall (P.robustus), fir mud mushrooms, exist eight species of mushrooms, such as dead leaves mud (P.pini), anti-cancer effect, immune enhancement, the tumor inhibitory effect, uterus It is known to be effective in treating gynecological diseases such as bleeding and menstrual irregularities. In addition, natural situation mushroom extract is reported to contain a large amount of various kinds of sugars and flavonoids, fiber, isoflavones and the like.

An object of the present invention is to provide a composition that can help to improve asthma by combining the black bellflower extract and the situation mushroom extract in accordance with the degree of bronchial diseases such as cough, sputum.

In order to achieve the above object,

According to one aspect of the present invention, it is possible to provide a composition that helps to improve asthma, using the black bellflower and the situation mushroom extract as an active ingredient.

The present invention is to prepare a bellflower known to be effective in relieving cough and phlegm, firstly prepared with black active bellflower with an increased active ingredient, the effect of the mixture when mixed with the situation mushrooms having an excellent effect on increasing immunity and in an appropriate ratio to improve asthma We will look at.

In one embodiment of the present invention, the extract was extracted from hot water extract of bellflower and situation mushroom, but not only the hot water extraction method, but also known extraction methods such as enzyme extraction and ultrasonic extraction may be used.

The black bellflower extract is extracted by adding 10-20 times the weight of water to the black bellflower, which is prepared by steaming and drying 6 ~ 15 times of preliminary dried bellflower.

The situation mushroom extract is finely ground and extracted by adding 15-20 times the weight of water.

Thus prepared black bellflower extract and situation mushroom extracts alone or in combination at an appropriate ratio to prepare a composition having an effect of improving asthma of the present invention.

According to one test example of the present invention, as shown in Table 4, group A who consumed the pouches prepared only with black bellflower extract had 63% of the subjects who answered that they improved after 15 days of ingestion. In addition, when taking a mixture of black mushrooms and the situation mushroom extract, it took a while, but most of the subjects answered that it was effective. The group E who consumed the pouch prepared only with the situation mushroom extract did not feel the improvement after 15 days, but most of them improved after one month of ingestion.

The improvement in phlegm was similar to coughing (see Table 5). In group A who consumed pouches made only from black bellflower extract, 70% of the subjects reported improvement after 15 days of intake. In addition, they took a relatively long time when they consumed a mixture of Sichuan mushroom extract in the black bellflower extract. In group E who consumed pouches prepared only with situational mushroom extracts, they did not feel any improvement after 15 days.

Therefore, according to the degree of bronchial diseases such as cough and sputum, it can be expected that a good effect can be expected by combining the black bellflower extract and the situation mushroom extract in an appropriate ratio. In other words, cough, sputum, etc., if acute or severe, put the black ratio large ratio to see the effect in the short term, and vice versa, if the cough, sputum, etc. is chronic, you can increase the ratio of the situation mushroom. .

According to another aspect of the invention, it is possible to present a health food containing the composition.

Bellflower and situation mushrooms have been used for food or medicinal since ancient times, so can be used safely as a health food material. Health food containing the bellflower and situation mushroom extract may be prepared by adding other food materials according to the commerciality and consumer preference of the final product.

The mixed amount of the active ingredient may be appropriately determined depending on the purpose of use (prevention, health or therapeutic treatment). Generally, in the manufacture of food or beverages the compositions of the invention are added in amounts of up to 15% by weight, preferably up to 10% by weight, based on the total raw material. However, in the case of long-term intake for the purpose of health and hygiene or health control, the amount may be below the above range, and the active ingredient may be used in an amount above the above range because there is no problem in terms of safety.

There is no particular limitation on the kind of the health food. Examples of such foods include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, dairy products, including gum, ice cream, various soups, beverages, teas, drinks, alcoholic beverages and vitamin complexes. This includes all of the functional foods in the usual sense.

The health functional food of the present invention may contain various flavors or natural carbohydrates and the like as additional ingredients, as in general beverages. Natural carbohydrates described above are glucose, monosaccharides such as fructose, disaccharides such as maltose and sucrose, and sugars such as polysaccharides, xylitol, sorbitol, and erythritol. Examples of sweeteners include natural sweeteners such as tau martin and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like.

In addition, the health food of the present invention includes various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, It may contain a carbonizing agent or the like for use in the carbonated beverages and the flesh for producing natural fruit juices, fruit juice drinks and vegetable drinks. These components can be used independently or in combination. The proportion of such additives is not critical but is generally selected in the range of 0.0 l to 10 parts by weight per 100 parts by weight of the composition of the present invention.

By combining the black bellflower extract and the situation mushroom extract in an appropriate ratio can help to improve bronchial diseases such as cough, sputum.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples, and those skilled in the art can make various changes within the spirit and scope of the present invention based on the detailed description and claims of the present invention. It will be appreciated that variations and applications are possible and such variations and applications fall within the scope of the present invention.

In order to prepare a composition having an asthma improving effect of the present invention, black bellflower extract and situation mushroom extract were prepared as follows.

Example 1-1. Manufacture of Black Bellflower

① Purchasing: Bellflower will be purchased for more than 3 years.

② Wash: Clean the bellflower.

③ Pre-drying: Dry bellflower at temperature of 40 ~ 60 ℃ for 8 ~ 24 hours.

④ Steaming: Steam for 3 ~ 12 hours while maintaining 70 ~ 95 ℃. (A)

⑤ Drying: Dry 12 ~ 48 hours at 45 ~ 60 ℃. (B)

⑥ Repeat the steps (A) and (B) 6 ~ 15 times.

Example 1-2. Preparation of Black Bellflower Extract

① Cutting: Cut black bellflower flat.

② Singer: Add black bellflower and 10 ~ 20 times of its weight to the extraction tank.

③ Extraction: Extract the extract for 5 ~ 12 hours at the temperature of 85 ~ 120 ℃.

④ Filtration: Filter after extraction.

⑤ sterilization: UV sterilization.

Example 2. Preparation of Situation Mushroom Extract

① Purchasing: Situation mushrooms can be purchased from Chinese medicine.

② Grinding: Grind the purchased mushrooms finely.

③ Heating: Add 15 ~ 20 times the water of the mushrooms and its weight and extract it for 5 ~ 12 hours at 85 ~ 120 ℃.

④ Filtration: Filter after cooling.

⑤ sterilization: UV sterilization.

Experimental Example 1 Evaluation of Asthma Improvement Efficacy of Mixtures of Black Bellflower and Situary Mushroom Extracts with Different Mixing Ratios

The major pharmacological component of bellflower was found to be triterpenoid-based saponins, which are effective in reducing phlegm by increasing bronchial secretion. In the process of drying and steaming bellflower, we tried to find out the effect of the mixture of the black bellflower and the situation mushroom extract with the increased active ingredient on cough, phlegm and asthma symptoms.

The experiment was carried out in the form of 80ml liquid pouch to facilitate the intake of the mixture.

① Test subject

The subjects of this study were 135 subjects who had frequent cough and sputum, and who voluntarily tested asthma in the hospital. The age and gender distribution of these test subjects is shown in [Table 1] and [Table 2].

[Table 1] Age distribution of test subjects

age Under 10 years old 10 20's 30 spaces 40 spaces 50 spaces 60 years old or older system persons 3 17 16 10 19 34 36 135 % 2.2 12.6 11.9 7.4 14.1 25.1 26.7 100.0

[Table 2] Gender distribution of subjects

gender male female system persons 89 46 135 % 65.9 34.1 100.0

② Experiment Method

Vacuum pouch packaging (80ml) was prepared by varying the contents of the black bellflower extract and the situation mushroom extract, and then ingested three times a day, and the result was performed by recording the result in a recording sheet. The experiment was conducted for 30 days.

Table 3 Classification of test subjects according to the blending ratio of black bellflower extract and situation mushroom extract

Experimental group Subject (persons) Mixing ratio (vol%) Black Bellflower Extract Situation Mushroom Extract A group 27 100 0 B group 27 75 25 C group 27 50 50 D group 27 25 75 E group 27 0 100

Experimental results were indicated for the improvement of cough and sputum after 15 and 30 days of ingestion of extracts compared to the beginning of the experiment.

③ result

1) an improved state of cough

[Table 4] Improvement state for the cough of the subject

15th  ^*) 30 days ^**) no effect commandment) A group 17 10 0 27 B group 12 14 One 27 C group 7 18 2 27 D group 2 23 2 27 E group 2 25 0 27

*) Feeling better after 15 days intake

**) Feeling better after 30 days intake

As shown in Table 4, the A group who consumed the pouches prepared only with black bellflower extract had 63% of the subjects who answered that they improved after 15 days of intake. In addition, when the black mushroom bellflower extract was mixed with the situation mushroom extract, it took a while, but most of the subjects answered that it was effective. In the case of the E group who consumed the pouches prepared only with the situation mushroom extract, they did not feel the improvement after 15 days.

2) Improved phlegm

The state of improvement of sputum in each test subject is shown in [Table 5].

[Table 5] Improvement state for the cough of the subject

15th  ^*) 30 days ^**) no effect commandment) A group 19 8 0 27 B group 15 12 0 27 C group 5 22 0 27 D group 3 23 One 27 E group 3 24 0 27

*) Feeling better after 15 days intake

**) Feeling better after 30 days intake

As shown in [Table 5], the improvement of phlegm was similar to that of cough.

A group who consumed pouches made only from black bellflower extract had 70% of the subjects who answered that they improved after 15 days of intake. In addition, when the situation mushroom extract was mixed with the black bellflower extract, it was relatively time-consuming but replied that it was effective. In the case of the E group who consumed the pouches prepared only with the situation mushroom extract, they did not feel the improvement after 15 days.

As a result, the black bellflower extract showed an excellent effect on cough and phlegm in a short time (15 days), and when it was mixed with the situation mushroom extract or black bellflower extract, it showed an effect on cough and phlegm after one month. Therefore, according to the degree of bronchial diseases such as cough, sputum, it is expected that a good effect can be expected if ingested by mixing the black bellflower extract and the situation mushroom extract in an appropriate ratio. In other words, cough, sputum, etc., acute or severe, put a black bellflower ratio to see the effect in a short time, and vice versa, if the cough, sputum, etc. in the chronic case of high intake of the situation of mushrooms to take the desired effect It is believed to be visible.

1 is a graph showing the cough improvement effect according to the mixing ratio of the black bellflower extract and the situation mushroom extract according to an embodiment of the present invention,

2 is a graph showing the sputum improvement effect according to the mixing ratio of the black bellflower extract and the situation mushroom extract according to an embodiment of the present invention.

Claims (4)

Black bellflower and situation mushroom extract as an active ingredient, a composition that helps to improve asthma. The composition of claim 1, wherein the black bellflower extract is prepared through a predrying step. According to claim 1, The black bellflower extract is prepared by performing the steaming and drying process 6-15 times, the composition. A health food comprising the composition of claim 1 to help improve asthma.

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