CN111012880A - Cough-relieving phlegm-eliminating candy and preparation method thereof - Google Patents
Cough-relieving phlegm-eliminating candy and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a cough-relieving phlegm-eliminating candy and a preparation method thereof, wherein the cough-relieving phlegm-eliminating candy is prepared from the following traditional Chinese medicine raw materials in parts by weight: 6-20 parts of loquat leaves, 6-18 parts of poppy shells, 3-12 parts of radix stemonae, 3-12 parts of cynanchum glaucescens, 3-12 parts of platycodon grandiflorum, 3-12 parts of cortex mori, 10-30 parts of momordica grosvenori and 0.5 part of menthol. The cough-relieving and phlegm-eliminating candy is used for treating chronic cough and bronchitis, and has the advantages of high cure rate and high effective rate.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to cough-relieving and phlegm-eliminating candy and a preparation method thereof.
Background
The chronic cough is the name of the disease syndrome. See book three of the book of elbow backup acute prescription. It refers to the disease with long-lasting cough, shortness of breath, hypodynamia, shortness of breath, and weak speech.
Bronchitis refers to chronic nonspecific inflammation of the trachea, bronchial mucosa, and surrounding tissues. Bronchitis is mainly caused by the chronic nonspecific inflammation of the bronchi resulting from repeated infections with viruses and bacteria. When the temperature is reduced, the respiratory tract small vessel spasm ischemia, defense function is reduced, and the like, the disease is favorably caused; chronic irritation such as smog and dust, and air pollution can also cause diseases; smoking causes bronchospasm, mucosal variation, ciliary movement reduction, mucus secretion increase and infection is benefited; allergic factors are also related. The clinical symptoms comprise cough, repeated cough, expectoration, asthma, repeated infection and prolonged course of disease. Clinically, the treatment is carried out by applying antibiotics such as erythromycin, azithromycin and the like, and medicines for eliminating phlegm, relieving cough and relieving asthma, and the disease is repeated, and the effect is not ideal.
The throat-moistening candy is a functional candy and has the functions of moistening and protecting throat. The components of the composition are as follows: white granulated sugar, fructus amomi, natural menthol, clove, dried orange peel and the like.
Buccal tablet is a pressed tablet slowly dissolved in oral cavity, can produce lasting drug effect on oral cavity and pharynx, and can be used for local inflammation diminishing and disinfection, such as sarcandra glabra buccal tablet.
Syrup refers to oral concentrated sucrose aqueous solution containing drugs, extracts of medicinal materials or aromatic substances. Syrups may be classified into simple syrups, medicinal syrups and aromatic syrups, depending on the components and the intended use.
The cough-relieving and phlegm-eliminating medicine is prepared with loquat leaf, poppy shell, stemona root, swallowwort rhizome, white mulberry root bark, balloonflower root, menthol and other Chinese medicinal materials.
In the prior art, a cough-relieving and phlegm-eliminating sugar preparation which is prepared from a traditional Chinese medicine prescription and is taken as a sugar block is not available, and the invention creates a precedent.
The invention prepares the cough-relieving and phlegm-eliminating candy which has excellent taste, prominent curative effect and is suitable for all ages by optimizing a prescription and improving a process on the basis of the strong loquat syrup, and fills the blank in the field.
Disclosure of Invention
In order to solve the technical problems, the invention provides a cough-relieving and phlegm-eliminating candy and a preparation method thereof.
The cough-relieving phlegm-eliminating candy comprises the following raw materials in parts by weight:
6-20 parts of loquat leaves, 6-18 parts of poppy shells, 3-12 parts of radix stemonae, 3-12 parts of cynanchum glaucescens, 3-12 parts of platycodon grandiflorum, 3-12 parts of cortex mori, 10-30 parts of momordica grosvenori and 0.5 part of menthol.
Preferably, the raw materials of the cough-relieving phlegm-eliminating candy comprise the following traditional Chinese medicine raw materials in parts by weight:
8-16 parts of loquat leaves, 10-15 parts of poppy shells, 5-9 parts of radix stemonae, 5-9 parts of cynanchum glaucescens, 5-9 parts of platycodon grandiflorum, 5-9 parts of cortex mori radicis, 15-25 parts of momordica grosvenori and 0.5 part of menthol.
More preferably, the raw materials of the cough-relieving phlegm-eliminating candy comprise the following traditional Chinese medicine raw materials in parts by weight:
8 parts of loquat leaf, 10 parts of poppy shell, 5 parts of radix stemonae, 5 parts of cynanchum glaucescens, 5 parts of platycodon grandiflorum, 5 parts of cortex mori, 15 parts of momordica grosvenori and 0.5 part of menthol.
More preferably, the raw materials of the cough-relieving phlegm-eliminating candy comprise the following traditional Chinese medicine raw materials in parts by weight:
16 parts of loquat leaf, 15 parts of poppy shell, 9 parts of stemona root, 9 parts of cynanchum glaucescens, 9 parts of platycodon grandiflorum, 9 parts of cortex mori, 25 parts of momordica grosvenori and 0.5 part of menthol.
More preferably, the raw materials of the cough-relieving phlegm-eliminating candy comprise the following traditional Chinese medicine raw materials in parts by weight:
13 parts of loquat leaf, 12 parts of poppy shell, 7 parts of stemona root, 8 parts of cynanchum glaucescens, 8 parts of platycodon grandiflorum, 7 parts of cortex mori, 20 parts of momordica grosvenori and 0.5 part of menthol.
The preparation method of the cough-relieving phlegm-eliminating candy comprises the following steps:
(1) weighing the raw materials except Mentholum in proportion, decocting in water for 2 times (each for 2 hr), mixing decoctions, concentrating at 75 deg.C to relative density of 1.20-1.25, and drying to obtain extract powder;
(2) pouring 1000 parts of honey or lactitol into a clean container, adding 250 parts of extraction powder and 0.5 part of menthol into 1000 parts of weighed honey or lactitol, uniformly stirring, adding 120 parts of water, uniformly stirring, finally adding 1000 parts of white granulated sugar or xylitol, heating while stirring, adding essence when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding and cooling to obtain the honey or lactitol oral liquid; or stirring, cooling, and extrusion molding.
Preferably, in the method for preparing the cough-relieving and phlegm-eliminating candy, the drying method may be vacuum drying or spray drying.
The preparation method of the cough-relieving phlegm-eliminating candy can also comprise the following steps:
(1) weighing the raw materials except Mentholum in proportion, decocting in water for 2 times (each for 2 hr), mixing decoctions, and concentrating at 75 deg.C to obtain extract with relative density of 1.20-1.25;
(2) pouring 1000 parts of honey or sugar-free excipient into a clean container, adding 250 parts of the extract powder and 0.5 part of menthol into 1000 parts of the weighed honey or sugar-free excipient, uniformly stirring, adding 120 parts of water, uniformly stirring, finally adding 1000 parts of white granulated sugar or sugar-free excipient, heating while stirring, adding essence when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding and cooling to obtain the honey or sugar-free excipient; or stirring, cooling, and extrusion molding.
The scent of the essence can be watermelon scent, freshener scent, orange oil scent, lemon scent, sarcandra glabra scent, honey scent, herbal scent, almond fruit scent, sweet scent, etc., but is not limited to the above-listed essence scents.
The sugar-free excipient can be one or more of maltitol, lactitol, xylitol or isomaltitol.
The cough-relieving and phlegm-eliminating candy disclosed by the invention has the effects of nourishing yin, astringing lung and relieving cough and eliminating phlegm, and can be used for treating bronchitis, chronic pharyngitis and chronic cough and fatigue.
In the prescription of the cough-relieving and phlegm-eliminating candy, loquat leaves clear away the lung-heat and relieve cough and quench thirst, poppy shells astringe the lung and relieve cough, momordica grosvenori relieves cough and moistens the lung, nourishes yin and relieves sore throat, sessile stemona root moistens the lung, relieves cough and eliminates phlegm, cynanchum glaucescens eliminates phlegm, relieves cough, white mulberry root-bark purges the lung and relieves asthma, promotes water and reduces swelling, menthol relieves sore throat and promotes eruption, platycodon grandiflorum is a messenger medicine. The recipe is good for treating chronic cough, cough and bronchitis, and has good effect and good specificity without losing.
The most preferred formulations of the present invention are as follows:
13 parts of loquat leaf, 12 parts of poppy shell, 7 parts of stemona root, 8 parts of cynanchum glaucescens, 8 parts of platycodon root, 7 parts of white mulberry root-bark, 20 parts of momordica grosvenori and 0.5 part of menthol
The formula is obtained by screening, and the screening process is as follows:
extracting medicinal materials with different formulas with water to obtain extractive solution, feeding to mouse (inducing cough with ammonia water in advance), and observing changes of cough frequency of mouse in 2 min; after feeding the mice for 3 days, phenol red physiological saline solution is injected, the trachea is separated, and the amount of phenol red is detected.
Wherein the cough frequency of the mice is reduced from 26 +/-6 to 9 +/-3 within 2 minutes by the most preferred formula, and the reduction is obvious; most preferably, the formulation has an average phenol red excretion of 8.66ug/ml, higher than other formulations.
The most preferred preparation method of the invention is as follows:
(1) weighing the raw materials except Mentholum in proportion, decocting in water for 2 times (each for 2 hr), mixing decoctions, concentrating at 75 deg.C to relative density of 1.20-1.25, and drying to obtain extract powder;
(2) pouring 1000 parts of honey or lactitol into a clean container, adding 250 parts of extraction powder and 0.5 part of menthol into 1000 parts of weighed honey or lactitol, uniformly stirring, adding 120 parts of water, uniformly stirring, finally adding 1000 parts of white granulated sugar or xylitol, heating while stirring, adding essence when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding and cooling to obtain the honey or lactitol oral liquid; or stirring, cooling, and extrusion molding.
Preferably, in the method for preparing the cough-relieving and phlegm-eliminating candy, the drying method may be vacuum drying or spray drying.
The most preferred preparation method of the present invention further comprises the following method:
(1) weighing the raw materials except Mentholum in proportion, decocting in water for 2 times (each for 2 hr), mixing decoctions, and concentrating at 75 deg.C to obtain extract with relative density of 1.20-1.25;
(2) pouring 1000 parts of honey or sugar-free excipient into a clean container, adding 250 parts of the extract powder and 0.5 part of menthol into 1000 parts of the weighed honey or sugar-free excipient, uniformly stirring, adding 120 parts of water, uniformly stirring, finally adding 1000 parts of white granulated sugar or sugar-free excipient, heating while stirring, adding essence when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding and cooling to obtain the honey or sugar-free excipient; or stirring, cooling, and extrusion molding.
The preparation method is obtained by screening, and the screening process is as follows:
1. decocting the raw materials except the menthol in water, and determining the decoction conditions of the effective components as follows:
as can be seen from the table, the transfer rate of the main ingredients of the medicinal materials tends to be stable between 120 minutes and 150 minutes after two times of decoction, most of the ingredients are decocted, and the time for decocting the water is set to be 2 hours.
The taste and the curative effect of different embodiments of the invention are compared
| Taste of the product | Curative effect on chronic bronchitis | Cure rate | |
| Example 1 | Slightly sweet and bland in drug flavor | Can be cured in 21 days | 67.4％ |
| Example 2 | Obvious granular sensation and strong medicinal taste | Can be cured in 7 days | 97.9％ |
| Example 3 | Has balanced medicinal taste and sweet taste, and no granular sensation | Can be cured in 12 days | 89.3％ |
| Example 4 | Has balanced medicinal taste and sweet taste, and no granular sensation | Can be cured in 12 days | 91.2％ |
| Example 5 | The sweet taste and the medicinal taste are not obvious | The cough symptom is still slight after 30 days | 49.7％ |
The invention is unexpected in that:
the product is obtained by adding fructus Siraitiae Grosvenorii into the prescription of strong fructus Eriobotryae syrup, and fructus Siraitiae Grosvenorii has effects of clearing away summer-heat, eliminating phlegm, relieving cough, cooling blood, relaxing bone, clearing lung-heat, moistening intestine, promoting fluid production, and quenching thirst; can be used for treating acute and chronic tracheitis, pharyngolaryngitis, bronchial asthma, pertussis, stomach heat, constipation, acute tonsillitis, etc., and is also suitable for diabetic patients. Modern medicine proves that the momordica grosvenori has obvious curative effect on bronchitis, hypertension and other diseases, and also has the function of preventing and treating coronary heart disease, angiosclerosis and obesity.
The present invention is not in the conventional art for the following reasons:
the product is a buccal sugar block, can play a long-acting role in oral cavity, soaks throat, relieves cough and eliminates phlegm, and has stronger pertinence than common swallow capsules, syrups and soft extracts. The product is convenient to carry, controllable in dosage each time, and lasting in efficacy.
The main components of the product are water decoction extract, sugar or sugar-free excipient, menthol and essence, the product has various tastes and is suitable for people of all ages, and the product has two tastes of sugar and sugar-free and can be used by diabetics.
Description of the drawings:
FIG. 1 shows the first and second decoction transfer rate screening
Detailed Description
The present invention will be described in further detail with reference to the following examples and specific embodiments, but the present invention is not limited thereto.
Example 1 sugar-containing antitussive expectorant candy
Prescription: 8 parts of loquat leaf, 10 parts of poppy shell, 5 parts of radix stemonae, 5 parts of cynanchum glaucescens, 5 parts of platycodon grandiflorum, 5 parts of cortex mori, 15 parts of momordica grosvenori and 0.5 part of menthol.
The preparation method comprises the following steps:
(1) weighing the raw materials except Mentholum in proportion, decocting in water for 2 times (each for 2 hr), mixing decoctions, concentrating at 75 deg.C to relative density of 1.20-1.25, and spray drying to obtain extract powder;
(2) pouring 10000g of honey into a clean container, adding 2500g of the extraction powder and 5g of menthol into 10000g of honey, uniformly stirring, adding 1200g of water, uniformly stirring, finally adding 10000g of white granulated sugar, stirring while heating, adding lemon flavor essence when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding, and cooling to obtain the lemon flavor essence. 1000 granules of cough-relieving and phlegm-eliminating candy are prepared together.
Example 2 sugar-free antitussive expectorant candy
Prescription: 16 parts of loquat leaf, 15 parts of poppy shell, 9 parts of stemona root, 9 parts of cynanchum glaucescens, 9 parts of platycodon grandiflorum, 9 parts of white mulberry root-bark, 25 parts of momordica grosvenori and 0.5 part of menthol
The preparation method comprises the following steps:
(1) weighing the raw materials except menthol according to a certain proportion, adding water, decocting for 2 times, each time for 2 hours, combining the decoctions, concentrating at 75 ℃ until the relative density is 1.20-1.25, and vacuum drying to obtain extract powder;
(2) pouring 10000g of xylitol into a clean container, adding 2500g of the extraction powder and 5g of menthol into 10000g of weighed xylitol, uniformly stirring, adding 1200g of water, uniformly stirring, finally adding 10000g of xylitol, stirring while heating, adding sarcandra glabra flavor when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding and cooling to obtain the product. 1000 granules of cough-relieving and phlegm-eliminating candy are prepared together.
Example 3 sugar-containing antitussive expectorant candy
Prescription: 13 parts of loquat leaf, 12 parts of poppy shell, 7 parts of stemona root, 8 parts of cynanchum glaucescens, 8 parts of platycodon grandiflorum, 7 parts of cortex mori, 20 parts of momordica grosvenori and 0.5 part of menthol.
(1) Weighing the raw materials except Mentholum in proportion, decocting in water for 2 times (each for 2 hr), mixing decoctions, and concentrating at 75 deg.C to obtain extract with relative density of 1.20-1.25;
(2) pouring 10000g of honey into a clean container, adding 2500g of the extraction paste and 5g of menthol into 10000g of honey, uniformly stirring, adding 1200g of water, uniformly stirring, finally adding 10000g of white granulated sugar, stirring while heating, adding herbal fragrance essence when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding and cooling to obtain the traditional Chinese medicine composition; or stirring, cooling, and extrusion molding.
Example 4 sugar-containing antitussive expectorant candy
Prescription: 13 parts of loquat leaf, 12 parts of poppy shell, 7 parts of stemona root, 8 parts of cynanchum glaucescens, 8 parts of platycodon grandiflorum, 7 parts of cortex mori, 20 parts of momordica grosvenori and 0.5 part of menthol.
(1) Weighing the raw materials except Mentholum in proportion, decocting in water for 2 times (each for 2 hr), mixing decoctions, and concentrating at 75 deg.C to obtain extract with relative density of 1.20-1.25;
(2) pouring 10000g of maltitol excipient into a clean container, adding 2500g of the extraction paste and 5g of menthol into 10000g of the weighed maltitol excipient, uniformly stirring, adding 1200g of water, uniformly stirring, finally adding 10000g of the maltitol excipient, stirring while heating, adding almond fruity essence when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding and cooling to obtain the almond fruity essence; or stirring, cooling, and extrusion molding.
Example 5
Prescription: 6 parts of loquat leaf, 6 parts of poppy shell, 3 parts of stemona root, 3 parts of cynanchum glaucescens, 3 parts of platycodon grandiflorum, 3 parts of cortex mori, 10 parts of momordica grosvenori and 0.5 part of menthol.
(1) Weighing the raw materials except Mentholum in proportion, decocting in water for 2 times (each for 2 hr), mixing decoctions, concentrating at 75 deg.C to relative density of 1.20-1.25, and spray drying to obtain extract powder;
(2) pouring 10000g of honey into a clean container, adding 2500g of the extraction powder and 5g of menthol into 10000g of honey, uniformly stirring, adding 1200g of water, uniformly stirring, finally adding 10000g of white granulated sugar, stirring while heating, adding the freshener flavor essence when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding and cooling to obtain the refreshing essence. 1000 granules of cough-relieving and phlegm-eliminating candy are prepared together.
Claims (10)
1. The cough-relieving phlegm-eliminating candy is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight:
6-20 parts of loquat leaves, 6-18 parts of poppy shells, 3-12 parts of radix stemonae, 3-12 parts of cynanchum glaucescens, 3-12 parts of platycodon grandiflorum, 3-12 parts of cortex mori, 10-30 parts of momordica grosvenori and 0.5 part of menthol.
2. The cough-relieving phlegm-eliminating candy according to claim 1, which is prepared from the following traditional Chinese medicine raw materials in parts by weight:
8-16 parts of loquat leaves, 10-15 parts of poppy shells, 5-9 parts of radix stemonae, 5-9 parts of cynanchum glaucescens, 5-9 parts of platycodon grandiflorum, 5-9 parts of cortex mori radicis, 15-25 parts of momordica grosvenori and 0.5 part of menthol.
3. The cough-relieving phlegm-eliminating candy according to claim 2 is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight:
8 parts of loquat leaf, 10 parts of poppy shell, 5 parts of radix stemonae, 5 parts of cynanchum glaucescens, 5 parts of platycodon grandiflorum, 5 parts of cortex mori, 15 parts of momordica grosvenori and 0.5 part of menthol.
4. The cough-relieving phlegm-eliminating candy according to claim 2, which is prepared from the following traditional Chinese medicine raw materials in parts by weight:
16 parts of loquat leaf, 15 parts of poppy shell, 9 parts of stemona root, 9 parts of cynanchum glaucescens, 9 parts of platycodon grandiflorum, 9 parts of cortex mori, 25 parts of momordica grosvenori and 0.5 part of menthol.
5. The cough-relieving phlegm-eliminating candy according to claim 2, which is prepared from the following traditional Chinese medicine raw materials in parts by weight:
13 parts of loquat leaf, 12 parts of poppy shell, 7 parts of stemona root, 8 parts of cynanchum glaucescens, 8 parts of platycodon grandiflorum, 7 parts of cortex mori, 20 parts of momordica grosvenori and 0.5 part of menthol.
6. The process for preparing a cough-relieving and phlegm-eliminating candy according to any one of claims 1 to 5, comprising the steps of:
(1) weighing the raw materials except Mentholum in proportion, decocting in water for 2 times (each for 2 hr), mixing decoctions, concentrating at 75 deg.C to relative density of 1.20-1.25, and drying to obtain extract powder;
(2) pouring 1000 parts of honey or lactitol into a clean container, adding 250 parts of extraction powder and 0.5 part of menthol into 1000 parts of weighed honey or lactitol, uniformly stirring, adding 120 parts of water, uniformly stirring, finally adding 1000 parts of white granulated sugar or xylitol, heating while stirring, adding essence when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding and cooling to obtain the honey or lactitol oral liquid; or stirring, cooling, and extrusion molding.
7. The method for preparing cough-relieving and phlegm-eliminating candy according to claim 6, wherein the drying method is selected from the group consisting of: vacuum drying or spray drying.
8. The process for preparing a cough-relieving and phlegm-eliminating candy according to any one of claims 1 to 5, comprising the steps of:
(1) weighing the raw materials except Mentholum in proportion, decocting in water for 2 times (each for 2 hr), mixing decoctions, and concentrating at 75 deg.C to obtain extract with relative density of 1.20-1.25;
(2) pouring 1000 parts of honey or sugar-free excipient into a clean container, adding 250 parts of the extract powder and 0.5 part of menthol into 1000 parts of the weighed honey or sugar-free excipient, uniformly stirring, adding 120 parts of water, uniformly stirring, finally adding 1000 parts of white granulated sugar or sugar-free excipient, heating while stirring, adding essence when the temperature rises to 130-160 ℃, uniformly stirring, pouring into a mold, molding and cooling to obtain the honey or sugar-free excipient; or stirring, cooling, and extrusion molding.
9. Use of the antitussive and expectorant saccharide according to any one of claims 1 to 5 in the manufacture of a medicament for the treatment of chronic cough and chronic fatigue.
10. Use of the antitussive and expectorant saccharide according to any one of claims 1 to 5 in the manufacture of a medicament for the treatment of bronchitis.
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| CN201911383969.0A CN111012880A (en) | 2019-12-28 | 2019-12-28 | Cough-relieving phlegm-eliminating candy and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1827152A (en) * | 2005-10-18 | 2006-09-06 | 吕武清 | Dispersible tablet with loquat and method for preparing the same |
| CN104800545A (en) * | 2015-05-06 | 2015-07-29 | 山东宏济堂制药集团有限公司 | Lung-moistening and cough-relieving sugar and preparation method and application thereof |
| CN109045231A (en) * | 2018-09-11 | 2018-12-21 | 华润三九（雅安）药业有限公司 | A kind of loquat dew and preparation method thereof |
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2019
- 2019-12-28 CN CN201911383969.0A patent/CN111012880A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1827152A (en) * | 2005-10-18 | 2006-09-06 | 吕武清 | Dispersible tablet with loquat and method for preparing the same |
| CN104800545A (en) * | 2015-05-06 | 2015-07-29 | 山东宏济堂制药集团有限公司 | Lung-moistening and cough-relieving sugar and preparation method and application thereof |
| CN109045231A (en) * | 2018-09-11 | 2018-12-21 | 华润三九（雅安）药业有限公司 | A kind of loquat dew and preparation method thereof |
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Address after: 214028 Changjiang South Road, new Wu District, Wuxi, Jiangsu Province, No. 12 Applicant after: Wuxi Jiyu Shanhe Pharmaceutical Co.,Ltd. Address before: 214028 No. 12 Changjiang South Road, New District, Jiangsu, Wuxi Applicant before: WUXI JIMIN KEXIN SHANHE PHARMACEUTICAL Co.,Ltd. |
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Application publication date: 20200417 |