CN103446564A - Traditional Chinese medicine composition for antisepsis and antiinflammation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for antisepsis and antiinflammation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for antisepsis and antiinflammation and a preparation method thereof. The traditional Chinese medicine composition comprises lycium barbarum, folia perillae acutae, dried rhizoma zingiberis recens, leonurus, scutellaria baicalensis and radix angelicae. The preparation method comprises the following steps of preparing materials; crushing; decocting; and concentrating. The traditional Chinese medicine composition has the advantages that the antisepsis and antiinflammation effect of the traditional Chinese medicine composition is equivalent to that of antibiotic western medicine; no drug resistance appears after long-term use; the traditional Chinese medicine composition is stable and reliable in effect, safe and free of toxic and side effects; the preparation method is simple and production cost is low.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, specifically Chinese medicine composition of a kind of anti-inflammation and preparation method thereof, belong to field of traditional Chinese.
Background technology
At present, traditional antibiosis anti-inflammatory drug mostly is the antibiotics Western medicine.The antibiotic Western medicine is named again antibacterium medicine (antibacterial) also referred to as " antibacterial agent ", is the medicine of a class for bacteria growing inhibiting or killing bacteria.The antibacterium medicine is also referred to as " antimicrobial drug ".Along with take all kinds of antibiotic that penicillin is representative, constantly occur, bacterial infection disease is effectively controlled, thereby makes antibiotic become the powerful mean that the mankind resist pathogenic bacterial infection.But in recent years, people use antibiotic to cause the drug resistance of antibacterial constantly to strengthen for a long time widely, and the drug resistance frequency increases gradually, so that conventional antibiotic can't meet clinical needs.Important change along with global disease and medical model, progressively integrating with of China and World Economics, culture and drug level, compatriots are enhanced to antibiotic understanding, recognize many untoward reaction and the impact of drug resistance accordingly thereof that antibiotic brings.Reusing for a long time a kind of Tri-Biocin may make pathogenic bacterium develop immunity to drugs.Therefore, the world and China propose to stop abuse of antibiotics class medicine at present.
Summary of the invention
In order to address the above problem, the present invention has designed Chinese medicine composition of a kind of anti-inflammation and preparation method thereof, this Chinese medicine composition not only anti-inflammation is suitable with the antibiotics western medicine result, and life-time service can not develop immunity to drugs yet, effect stability is reliable, safety is without secondary toxic action, and preparation method is simple, and production cost is low.
Technical scheme of the present invention is:
A kind of Chinese medicine composition of anti-inflammation is mixed with by the crude drug of following dosage:
Fructus Lycii 30-40 gram, Folium Perillae 66-70 gram, dry Rhizoma Zingiberis Recens 12-16 gram, Herba Leonuri 46-52 gram, Radix Scutellariae 35-45 gram, Radix Angelicae Dahuricae 20-30 gram.
Preferably, Fructus Lycii 34 grams, Folium Perillae 68 grams, dry Rhizoma Zingiberis Recens 14 grams, Herba Leonuri 49 grams, Radix Scutellariae 38 grams, the Radix Angelicae Dahuricae 26 grams.
Fructus Lycii, refer to commodity " Fructus Lycii ", refers to the dry mature fruit that derives from lycium barbarum.Fructus Lycii has nourishing the liver, nourishing kidney, lung moistening, tonify deficiency benefit essence, clearing away heat to improve acuity of vision, the effect of enhancing immunity.The heat symptom-complex that all void are hyperfunction, the disease patient such as do not move back such as deficiency-heat after pulmonary tuberculosis later stage, diabetes yin asthenia generating intrinsic heat, infantile measles suitable edible.Mainly utilize Fructus Lycii hemopoietic in the present invention, enhance metabolism, the effect of enhancing immunity etc., make human body that a good interior environment can be arranged in the process of anti-inflammation.
Folium Perillae, be the leaf of labiate Folium Perillae, another name Huis Soviet Union, Folium Perillae.Nature and flavor are hot, warm.Effect: the cold expelling that induces sweat, relieving QI stagnancy in the stomach, for anemofrigid cold, cough and asthma, vomiting during pregnancy, frequent fetal movement, the fish Eriocheir sinensis is poisoning.Give the rabbit gavage of experimental heating with Folium Perillae decoct or preserved material, the refrigeration function of mitigation is arranged; Produce the leachate of Folium Perillae with Korea, pour into to the rabbit of heating, weak refrigeration function is also arranged; With water decoction, escherichia coli, dysentery bacterium, staphylococcus are all had to inhibitory action.In the present invention, mainly utilize Folium Perillae induce sweat cold expelling with and the effective effect of anti-bacteria of water decoction
Rhizoma Zingiberis Recens is the rhizome of zingiber.The Rhizoma Zingiberis Recens nature and flavor are hot, tepor.Effect: warming middle-JIAO dries, delivers, and cold expelling, preventing or arresting vomiting, open expectorant, the wind and cold that cures cold, the vomiting phlegm retention, breath with cough, and distension, have loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Scientist finds by research, and Rhizoma Zingiberis Recens can play the effect of some antibiotics, especially to the Salmonella successful.Rhizoma Zingiberis Recens is killed the effect of oral cavity pathogen and pathogenic entero becteria in addition, with gingerade rinsing the mouth treatment halitosis and periodontitis, evident in efficacy, and utilizes just the effect of Rhizoma Zingiberis Recens anti-inflammation in the present invention.
Herba Leonuri, acrid in the mouth, hardship, cool.Effect: the silt of dispelling, invigorate blood circulation, regulating menstruation, diuretic, control menoxenia, premature labor, difficult labour, retention of placenta, puerperal blood faints, addiction hemoperitoneum pain, metrorrhagia, hematuria, rush down blood, the carbuncle skin infection.The Herba Leonuri herb containing leonurine approximately 0.05%, stachydrine, rutin, Fumaric acid, leonurine first and leonurine second.The Herba Leonuri Sibirici herb is containing alkaloid 0.05%, and in herb, the content of leonurine changed with the period of blooming, and the initial stage content of spending is very micro-, and it is 0.01-0.03% that 7-8 spends mid-term content the middle of the month, reaches as high as 0.04%, and containing stachydrine and leonuridine alkali.Contain a large amount of alkaloids in the decoct of Herba Leonuri, the water logging agent (1:4) of Herba Leonuri has inhibitory action to the growth of dermatophytes in vitro.The present invention utilizes the effect of alkaloids anti-bacterias a large amount of in the Herba Leonuri water decoction just.
Radix Scutellariae: Radix Scutellariae another name Radix Scutellariae, tsuchikane tea root, heat clearing and damp drying is arranged, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.The strong characteristics by broad-spectrum antibacterial action, be used in fungal culture and infect special severe miscellaneous bacteria, good by Radix Scutellariae extracting solution effect.The baicalin contained in the Radix Scutellariae water decoction, baicalin have significant inhibitory action to arthritis; baicalin has significant inhibitory action to rheumatoid arthritis, gamma globulin degeneration; to arthritis Secondary cases bone, infringement has protective effect, can suppress degeneration and the destruction of sclerotin.Radix Scutellariae has significant inhibitory action or mitigation to the animal allergic asthma, and with ephedrine, synergism is arranged.Baical skullcap root flavonoids fractions has the effect of antibiotic, antivirus action and the inhibition ameba of significant wide spectrum, experimental heating is had to significant analgesic cooling effect, therefore that Radix Scutellariae has is analgesic, removing toxic substances and antiviral effect, is excellent anti-inflammation class Chinese herb.
The Radix Angelicae Dahuricae: wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.For headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Main containing compositions such as volatile oil methyl cyclodecane and Coumarins oxypeucedanins in Radix Angelicae Dahuricae water decoction, that these compositions have is analgesic, antiinflammatory, analgesic effect, experimental results show that, Radix Angelicae Dahuricae decocting liquid has obvious refrigeration function, mice auricle swelling is had to inhibitory action the rabbit heating, and rat experiment arthritis is had to antiinflammatory action.
The present invention passes through Fructus Lycii, Folium Perillae, dry Rhizoma Zingiberis Recens, Herba Leonuri, Radix Scutellariae, Radix Angelicae Dahuricae hybrid combination, it is complemented each other, learn from other's strong points to offset one's weaknesses, the drug effect reached after above-mentioned Chinese medicine is mixed will be far longer than the effect that single medicinal material plays, and then has reached the effect of anti-inflammation.
The preparation method of the Chinese medicine composition of above-mentioned anti-inflammation comprises the following steps:
(1) get the raw materials ready: according to each crude drug component of above-mentioned weight proportion weighing;
(2) pulverize: by the raw material pulverizing of step (1), cross the 150-200 mesh sieve, mix;
(3) decoct: the mixture of step (2) is entered in digester, add water boil, continue again after boiling to decoct 10 minutes, filter, remove slag;
(4) concentrated: the medicinal liquid after step (3) is removed slag reenters in digester and boils, and after keeping boiling 30 minutes, within standing 24 hours, gets final product.
During use, this Chinese medicine composition is made to water preparation, the cotton affected part of cleaning of direct drug injection gets final product, and cleans every day 2 times, and each 2-5 milliliter, consider medication depending on the state of an illness.Use this Chinese medicine preparation, the treatment short treating period, can not cause skin peeling, allergy, and the radical cure therapeutic effect is remarkable, and non-stimulated to human body, has no side effect.
The invention has the advantages that: this Chinese medicine composition not only anti-inflammation is suitable with the antibiotics western medicine result, and life-time service can not develop immunity to drugs yet, and effect stability is reliable, and safety is without secondary toxic action, and preparation method is simple, and production cost is low.
The specific embodiment
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein, only for description and interpretation the present invention, is not intended to limit the present invention.
Embodiment 1
A kind of Chinese medicine composition of anti-inflammation is mixed with by the crude drug of following dosage:
Fructus Lycii 30 grams, Folium Perillae 66 grams, dry Rhizoma Zingiberis Recens 12 grams, Herba Leonuri 46 grams, Radix Scutellariae 35 grams, the Radix Angelicae Dahuricae 20 grams.
Embodiment 2
A kind of Chinese medicine composition of anti-inflammation is mixed with by the crude drug of following dosage:
Fructus Lycii 40 grams, Folium Perillae 70 grams, dry Rhizoma Zingiberis Recens 16 grams, Herba Leonuri 52 grams, Radix Scutellariae 45 grams, the Radix Angelicae Dahuricae 30 grams.
Embodiment 3
A kind of Chinese medicine composition of anti-inflammation is mixed with by the crude drug of following dosage:
Fructus Lycii 34 grams, Folium Perillae 68 grams, dry Rhizoma Zingiberis Recens 14 grams, Herba Leonuri 49 grams, Radix Scutellariae 38 grams, the Radix Angelicae Dahuricae 26 grams.
Embodiment 4
A kind of preparation method of the Chinese medicine composition for the described anti-inflammation of embodiment 1-3 comprises the following steps:
(1) get the raw materials ready: according to each crude drug component of above-mentioned weight proportion weighing;
(2) pulverize: by the raw material pulverizing of step (1), cross the 150-200 mesh sieve, mix;
(3) decoct: the mixture of step (2) is entered in digester, add water boil, continue again after boiling to decoct 10 minutes, filter, remove slag;
(4) concentrated: the medicinal liquid after step (3) is removed slag reenters in digester and boils, and after keeping boiling 30 minutes, within standing 24 hours, gets final product.
Embodiment 5
The inhibitory action routine test of Chinese medicine composition of the present invention to clinical common microorganism, in order to verify the fungistatic effect of Chinese medicine composition of the present invention, the applicant entrusts Medicine Institute, Shandong Province to do bacteriostatic experiment and Drug resistance experiment.
One, bacteriostatic experiment
Under equal conditions, cultivate respectively each 1000, staphylococcus aureus, Pseudomonas aeruginosa, Hemolytic streptococcus, clostridium tetani, tubercule bacillus and six kinds of antibacterials of chlamydia trachomatis in 12 test tubes, be divided into two groups, label is A, B, C, D, E and F successively, compare with penicillin, and do blank.Concrete experimental data as shown in Table 1.
Table one
In table one, Chinese medicine composition of the present invention is along with the lengthening of time, and the number of six kinds of antibacterials is fewer and feweri, and 1000 from beginning after one week reduce to less than 100, and fungistatic effect is obvious, with the blank group, compares, and effect is better obviously; Although penicillin is instant effect in one day, along with the time lengthens again, the bacteriostasis and sterilization DeGrain, and also after one week, the antibacterial number rebounds to some extent, illustrates that the antibacterial of survival has Drug resistance, and start the breeding growth; In blank group middle and late stage antibacterial number, reducing, is because the continuous breeding of antibacterial in test tube causes the ph value to surpass 9, has suppressed the Growth and Reproduction of antibacterial.
Two, Drug resistance experiment
Under equal conditions, get six kinds of antibacterials that survive after seven days in the biocidal property experiment in test tube, be staphylococcus aureus, Pseudomonas aeruginosa, Hemolytic streptococcus, clostridium tetani, tubercule bacillus and chlamydia trachomatis, label is A, B, C, D, E and F successively, with penicillin, compare, and again in six test tubes, add medicine water decoction of the present invention and penicillin, wherein add dosage with between the addition agent amount identical, concrete experimental data is as shown in Table 2.
Table two
In table two, after continuing to add the water decoction of Chinese medicine composition of the present invention, bacterial disease remaining in former test tube is killed, and illustrates that remaining antibacterial does not develop immunity to drugs, and its survival is because pharmaceutical quantities can not continue, but not remaining antibacterial develops immunity to drugs; And after the matched group penicillin continues to add, starting had certain effect in six hours, and after 12 hours, bacterial number starts bounce-back, after 24 hours, the quantity that bacterial number maintains while starting even surpasses quantity while starting, illustrate that the remaining antibacterial after the biocidal property experiment has Drug resistance, cause bacterial number after 12 hours to start bounce-back, and finally meet or exceed initial value.
In sum, the water decoction of Chinese medicine composition of the present invention all has inhibition, bactericidal action to staphylococcus aureus, Pseudomonas aeruginosa, Hemolytic streptococcus, clostridium tetani, tubercule bacillus and chlamydia trachomatis, and successful, in addition, long period is used Chinese medicine composition water decoction of the present invention can not cause antibacterial to develop immunity to drugs, but has a broad antifungal spectrum.
Finally it should be noted that: the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment, the present invention is had been described in detail, for a person skilled in the art, its technical scheme that still can put down in writing aforementioned each embodiment is modified, or part technical characterictic wherein is equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (5)
1. the Chinese medicine composition of an anti-inflammation, is characterized in that, by the crude drug of following dosage, is mixed with:
Fructus Lycii 30-40 gram, Folium Perillae 66-70 gram, dry Rhizoma Zingiberis Recens 12-16 gram, Herba Leonuri 46-52 gram, Radix Scutellariae 35-45 gram, Radix Angelicae Dahuricae 20-30 gram.
2. Chinese medicine composition according to claim 1, is characterized in that, by the crude drug of following dosage, is mixed with:
Fructus Lycii 34 grams, Folium Perillae 68 grams, dry Rhizoma Zingiberis Recens 14 grams, Herba Leonuri 49 grams, Radix Scutellariae 38 grams, the Radix Angelicae Dahuricae 26 grams.
3. Chinese medicine composition according to claim 1, is characterized in that, by the crude drug of following dosage, is mixed with:
Fructus Lycii 30 grams, Folium Perillae 66 grams, dry Rhizoma Zingiberis Recens 12 grams, Herba Leonuri 46 grams, Radix Scutellariae 35 grams, the Radix Angelicae Dahuricae 20 grams.
4. Chinese medicine composition according to claim 1, is characterized in that, by the crude drug of following dosage, is mixed with:
Fructus Lycii 40 grams, Folium Perillae 70 grams, dry Rhizoma Zingiberis Recens 16 grams, Herba Leonuri 52 grams, Radix Scutellariae 45 grams, the Radix Angelicae Dahuricae 30 grams.
5. the preparation method for the described Chinese medicine composition of claim 1-4 any one, is characterized in that, comprises the following steps:
(1) get the raw materials ready: according to each crude drug component of above-mentioned weight proportion weighing;
(2) pulverize: by the raw material pulverizing of step (1), cross the 150-200 mesh sieve, mix;
(3) decoct: the mixture of step (2) is entered in digester, add water boil, continue again after boiling to decoct 10 minutes, filter, remove slag;
(4) concentrated: the medicinal liquid after step (3) is removed slag reenters in digester and boils, and after keeping boiling 30 minutes, within standing 24 hours, gets final product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106728909A (en) * | 2016-12-30 | 2017-05-31 | 心颐和国际中医药投资控股（北京）有限公司 | A kind of Chinese medicine composition with antibiotic effect and preparation method thereof |
| CN107648130A (en) * | 2017-11-17 | 2018-02-02 | 蚌埠崇迪生物科技有限公司 | A kind of anti-inflammation gargle water and preparation method thereof |
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| CN1539441A (en) * | 2003-04-22 | 2004-10-27 | 黄益新 | Compounded medicine for anti pathogeny and immunoenhancement |
| CN101318006A (en) * | 2008-07-09 | 2008-12-10 | 杨利群 | Anti-bacterial, anti-itching externally used nursing formulation of traditional Chinese medicine |
| CN102861208A (en) * | 2012-09-19 | 2013-01-09 | 王吉坤 | Antibacterial, anti-inflammation and antiviral traditional Chinese medicine compound |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1539441A (en) * | 2003-04-22 | 2004-10-27 | 黄益新 | Compounded medicine for anti pathogeny and immunoenhancement |
| CN101318006A (en) * | 2008-07-09 | 2008-12-10 | 杨利群 | Anti-bacterial, anti-itching externally used nursing formulation of traditional Chinese medicine |
| CN102861208A (en) * | 2012-09-19 | 2013-01-09 | 王吉坤 | Antibacterial, anti-inflammation and antiviral traditional Chinese medicine compound |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728909A (en) * | 2016-12-30 | 2017-05-31 | 心颐和国际中医药投资控股（北京）有限公司 | A kind of Chinese medicine composition with antibiotic effect and preparation method thereof |
| CN107648130A (en) * | 2017-11-17 | 2018-02-02 | 蚌埠崇迪生物科技有限公司 | A kind of anti-inflammation gargle water and preparation method thereof |
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