CN104189451A - Heat-clearing and toxicity-removing soup for suppurated-type septicemia and preparation method - Google Patents
Heat-clearing and toxicity-removing soup for suppurated-type septicemia and preparation method Download PDFInfo
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Abstract
The invention discloses a heat-clearing and toxicity-removing soup for suppurated-type septicemia. The heat-clearing and toxicity-removing soup is prepared from the following bulk drugs in parts by weight: 25-40 parts of folium isatidis, 10-20 parts of radix ophiopogonis, 6-10 parts of Rulvis Glycyrrhizae Extractionis Sedilis, 10-16 parts of cape jasmine, 18-30 parts of radix scrophulariae, 20-40 parts of honeysuckle, 6-12 parts of platycodon grandiflorum, 2-6 parts of wild carrot fruit, 12-25 parts of gypsum, 4-9 parts of tropic ageratum herb, 12-25 parts of rhizoma anemarrhenae, 8-16 parts of the root of straight ladybell, 12-20 parts of raw tortoise plastron, 9-15 parts of goldthread, 5-15 parts of sophora flower bud, 4-9 parts of periwinkle, 8-16 parts of Angelica sinensis, 2-5 parts of milk vine and 3-9 parts of radix angelicae. The suppurated-type blood poisoning heat-clearing and toxicity-removing soup has the main effects of clearing away heat and toxic materials, diminishing inflammation and relieving pain, has good eliminating and inhibiting effects on pathogenic bacteria and toxin in blood and obvious therapeutical effect on the suppurated-type septicemia, and the resistance of organisms is also improved.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of Qingre Jiedu Tang for the treatment of suppuration type septicemia and preparation method thereof.
Background technology
Septicemia is caused a kind of acute systemic infection in blood due to pathogenic microorganism and toxic product sustainable existence thereof, also referred to as " systemic infection ".Septicemia is generally in the situation that Abwehrkraft des Koepers extremely reduces, and after cause pathogeny imcrobe infection, breaks through very soon the immune system of body, enters blood circulation, and raised growth breeding, spreads to the each organ of whole body, makes body in serious toxic state.Septicemia is not independently disease of one, is clinical symptoms common in many infectious disease or non-infective disease, due to the difference in age, and patient's underlying diseases difference, afferent pathway and age bracket be the impact of equal factor not, and the antibacterial that causes septicemia is also different.
Suppuration type septicemia is that local infection is suppurated, and the form of suppuration antibacterial one embolus enters blood, to whole body, forms transitivity suppuration focus at other tissue, organ with blood transfer.Taking shiver with cold, high heat, erythra, arthralgia and hepatosplenomegaly as feature, part can have septic shock and migrate sexually transmitted disease (STD) kitchen range clinically, and agitation, extreme cold of the limbs and cyanosis, thready pulse speed, tachypnea, blood pressure drops etc. also can appear in some patients were.The suppurative septicemia of clinical treatment is used antibiotic to eliminate as early as possible all antibacterials in blood more, to the suppurative focus of constitutional or migrating property, incision and drainage in time after maturation, antimicrobial drug also can be injected in suppurative pericarditis, arthritis, empyema and liver abscess part after drain.Publication number CN 102357185A(application number 201110331238.9) Chinese patent literature the Chinese medicine for the treatment of septicemia is disclosed, this Chinese medicine is by Bulbus Fritillariae Thunbergii 18g, Fructus Trichosanthis shell 24g, Pumex 18g, Radix Platycodonis 15g, 30 parts of Radix Astragali, 10 parts of Radix Scutellariaes, 10 parts of Radix Rehmanniae, 10 parts of Radix Glycyrrhizae are prepared from.Publication number CN 103301252A(application number 201210071137.7) Chinese patent literature a kind of Chinese medicinal preparation method for the treatment of septicemia is disclosed, this Chinese medicine is with 90 grams of Radix Isatidis, 90 grams of Flos Chrysanthemi Indicis, 80 grams of Herba Scutellariae Barbataes, 75 grams of Herba Violaes, 75 grams of Herba Houttuyniae, 60 grams of Folium Isatidiss, 60 grams of Herba Taraxacis, 55 grams of Herba Andrographitiss, 55 grams, the fresh Radix Rehmanniae, 50 grams of Flos Lonicerae, 50 grams of Fructus Forsythiaes, 3000 grams, water is raw material composition.Publication number CN 102327439A(application number 201110276161.X) Chinese patent literature treatment septicemia Chinese herbal medicine is disclosed, this formula is by Cornu rhinocerotis 3-6 part, Radix Rehmanniae 35-55 part, Radix Paeoniae Rubra 15-25 part, Cortex Moutan 15-25 part, Rhizoma Coptidis 15-25 part, Radix Scutellariae 25-35 part, Cortex Phellodendri 25-35 part, Fructus Gardeniae 25-35 part, Rhizoma Paridis 15-25 part, Herba Hyperici Japonici 15-25 part, Herba Melastomatis Candii 25-35 part, Flos Ilicis Asprellae 15-25 part composition.
When treatment suppuration type septicemia, if antibiotic improper use can have side effects, as various dysbacteriosiss in the generation of Resistant strain and body, diagnosis, treatment that various antibacterials are infected all can impact, so intravenously administrable intermittently.And aspect treatment suppuration type septicemia, Chinese medicine has certain advantage, it has safe without toxic side effect, and be suitable for the advantages such as long-term taking, but effect is clinically not remarkable, cause it further not promote the use of, therefore, Chinese medicine also needs further raising to the curative effect of suppuration type septicemia.
Summary of the invention
For making up the defect of prior art, the object of this invention is to provide a kind of simple, good effect, easy Qingre Jiedu Tang of the treatment suppuration type septicemia of clothes and preparation method thereof for a long time prepared.This Qingre Jiedu Tang determined curative effect and having no side effect.
Technical scheme of the present invention is:
The Qingre Jiedu Tang of suppuration type septicemia, is prepared from by following bulk drugs, is weight portion: Folium Isatidis 25-40, Radix Ophiopogonis 10-20, Preparatum Glycyrrhizae 6-10, Fructus Gardeniae 10-16, Radix Scrophulariae 18-30, Flos Lonicerae 20-40(is preferred, Flos Lonicerae 25-35; Be more preferably Flos Lonicerae 32), Radix Platycodonis 6-12, Fructus Carotae 2-6, Gypsum Fibrosum 12-25, Herba Agerati Conyzoidis 4-9, Rhizoma Anemarrhenae 12-25, Radix Adenophorae (Radix Glehniae) 8-16, raw tortoise plastron 12-20, Rhizoma Coptidis 9-15, Flos Sophorae Immaturus 5-15, Herba Catharanthi Rosei 4-9, Radix Angelicae Sinensis 8-16, the Trionyx sinensis Wiegmann 2-5 that climbs the tree, Radix Angelicae Dahuricae 3-9.
In preferred scheme, Folium Isatidis 30-35, Radix Ophiopogonis 13-17, Preparatum Glycyrrhizae 7-9, Fructus Gardeniae 12-14, Radix Scrophulariae 20-28, Flos Lonicerae 25-35, Radix Platycodonis 8-10, Fructus Carotae 3-5, Gypsum Fibrosum 15-22, Herba Agerati Conyzoidis 5-8, Rhizoma Anemarrhenae 15-22, Radix Adenophorae (Radix Glehniae) 10-14, raw tortoise plastron 15-17, Rhizoma Coptidis 10-14, Flos Sophorae Immaturus 7-13, Herba Catharanthi Rosei 5-8, Radix Angelicae Sinensis 10-14, the Trionyx sinensis Wiegmann 3-4 that climbs the tree, Radix Angelicae Dahuricae 5-7.
Be more preferably, Folium Isatidis 32.5, Radix Ophiopogonis 15, Preparatum Glycyrrhizae 8, Fructus Gardeniae 13, Radix Scrophulariae 24, Flos Lonicerae 30, Radix Platycodonis 9, Fructus Carotae 4, Gypsum Fibrosum 18.5, Herba Agerati Conyzoidis 6.5, the Rhizoma Anemarrhenae 18.5, Radix Adenophorae (Radix Glehniae) 12, raw tortoise plastron 16, Rhizoma Coptidis 12, the Flos Sophorae Immaturus 10, Herba Catharanthi Rosei 6.5, Radix Angelicae Sinensis 12, the Trionyx sinensis Wiegmann 3.5 that climbs the tree, the Radix Angelicae Dahuricae 6.
The preparation method of described Qingre Jiedu Tang is:
(1) raw tortoise plastron is used to sand parching to brown, immersed while hot in vinegar, after rinsing with clear water, dry, make vinegar Carapax et Plastrum Testudinis;
(2) first vinegar Carapax et Plastrum Testudinis is put into marmite, decoct with water after 10 minutes, add again Gypsum Fibrosum to decoct 25-35 minute (preferably 30 minutes), finally Folium Isatidis, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Gardeniae, Radix Adenophorae (Radix Glehniae), Radix Platycodonis, Fructus Carotae, Herba Agerati Conyzoidis, the Rhizoma Anemarrhenae, Rhizoma Coptidis, the Flos Sophorae Immaturus, Herba Catharanthi Rosei, Radix Angelicae Sinensis, Radix Scrophulariae, climb the tree Trionyx sinensis Wiegmann and Preparatum Glycyrrhizae are put into marmite, after being fried open, intense fire turns again 20-30 at a simmer minute (preferably 25 minutes), supernatant is collected in filtration, leave recrement, recrement is watered intense fire again and is fried open, turn after at a simmer and leach supernatant, by twice supernatant mix homogeneously, stand-by;
(3) Flos Lonicerae decontamination is cleaned, dry, add 85% alcohol solvent to soak 2-3 hour (preferably 2.5 hours), then heating and refluxing extraction 1-2 hour (preferably 1.5 hours), filter to get filtrate, repeat to extract three times, three filtrates are merged, be concentrated into 1/3rd concentrated solution of original volume, for subsequent use;
(4) by above-mentioned steps (2) and (3) prepared supernatant and concentrated solution mix homogeneously, point install in the vial that the high temperature sterilize of 400ml crosses, sterilizing potting, stand-by.
The preparation method of described Qingre Jiedu Tang, described step (2) is first vinegar Carapax et Plastrum Testudinis and Gypsum Fibrosum to be smashed to pieces respectively, then packs tightly with gauze vinegar Carapax et Plastrum Testudinis and the Gypsum Fibrosum smashed to pieces.
The preparation method of described Qingre Jiedu Tang, described step (2) is that Preparatum Glycyrrhizae is contained in gauze bag, then decocts together with other medicines.
The preparation method of described Qingre Jiedu Tang, in described step (2), amount of water is doubly (preferably 7-9 doubly, is more preferably 8 times) of 6-10 of medical material gross weight.
The preparation method of described Qingre Jiedu Tang, in described step (3), the amount of 85% ethanol is doubly (preferably 6-8 doubly, is more preferably 7 times) of 5-9 of Flos Lonicerae weight.
The preparation method of described Qingre Jiedu Tang, in described step (3), the temperature of reflux is 70-80 DEG C (preferably 72-78, is more preferably 75 DEG C).
The application of Qingre Jiedu Tang described in the present invention also provides in the time for the treatment of suppuration type septicemia.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Folium Isatidis: nature and flavor: hardship, cold.Gui Jing: GUIXIN, stomach warp.Effect: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Cure mainly: for the high heat of epidemic febrile disease, coma, sends out speckle dermexanthesis, mumps, sore throat, erysipelas, carbuncle.
Radix Ophiopogonis (Radix Ophiopogonis): nature and flavor: sweet, micro-hardship, is slightly cold.Gui Jing: GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Cure mainly: for dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Preparatum Glycyrrhizae: sweet in the mouth, salty; Cold in nature.GUIXIN, stomach warp.Be a kind of fabricated product, for Radix Glycyrrhizae powder is put in thick bamboo tube, in people manure pit, flood the manufactured goods after certain hour.There is clearing away heat and cooling blood; Effect of eliminating fire and detoxication.Cure mainly a day row calentura; Epidemic febrile disease is sent out speckle; Large hot excessive thirst; Variola heat in blood; Erysipelas; Skin infection.In essentials of Matea Medica, record: " purge heat, clearing away phlegm fire, helps digestion long-pending, the five internal organs excess-heat of having a bowel movement.Control day row fanatical, variola heat in blood, black can not falling into.”
Fructus Gardeniae: nature and flavor: hardship, cold.Gui Jing: GUIXIN, lung, tri-jiao channel.Effect: pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Externally used detumescence pain relieving.Cure mainly: vexed for calentura, jaundice due to damp-heat, the puckery pain of stranguria, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles, external treatment bruise pain.
Radix Scrophulariae (Radix Scrophulariae): nature and flavor: sweet, bitter, salty, be slightly cold.Gui Jing: return lung, stomach, kidney channel.Effect: clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens.Cure mainly: enter nutrient blood for heat, maculae caused by violent heat pathogen, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, diphtheria, scrofula, carbuncle sore tumefacting virus.
Flos Lonicerae (Flos Lonicerae): nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, dispelling wind and heat pathogens.Cure mainly: treat skin ulcer for carbuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.
Radix Platycodonis: nature and flavor: bitter, pungent, flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Fructus Carotae: base is former: be the fruit of Umbelliferae Daucus plant Daucus carota L..Pharmacology: Cardiovarscular is had to significant curative effect, have the effect of shrinking uterus.Nature and flavor: pungent, bitter, flat, slightly poisonous.Cure mainly: have parasite killing, removing food stagnancy, antipruritic effect.
Gypsum Fibrosum: nature and flavor: pungent, sweet.Gui Jing: return stomach, lung meridian.Effect: clearing away heat-fire, relieving restlessness is quenched the thirst.Cure mainly: for fever caused by exogenous pathogenic factors, high hot excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.
Herba Agerati Conyzoidis: base is former: be the herb of Compositae Ageratum plant Ageratum conyzoides.Composition: herb is containing flavonoid, alkaloid, triterpenoid compound, volatile oil.I have chromene class aerial parts.Pharmacology: cardiac muscle is had to stimulation, smooth muscle is had to inhibitory action, have the effect of anti-inflammatory and antalgic, have antibacterial effect.Nature and flavor: micro-hardship, pungent, cool.Effect: heat-clearing and toxic substances removing.Cure mainly hemostasis, pain relieving.
The Rhizoma Anemarrhenae: nature and flavor: bitter, sweet, cold.Gui Jing: return lung, stomach, kidney channel.Effect: clearing away heat-fire is nourshing Yin and drynsessmoistening prescription.Cure mainly: for fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Radix Adenophorae (Radix Glehniae) (Radix Adenophorae): nature and flavor: sweet, be slightly cold.Gui Jing: attach to the lung and stomach meridians.Effect: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, reduces phlegm, QI invigorating.Cure mainly: for lung-heat type cough, deficiency of YIN chronic cough, dry cough expectorant is glutinous, deficiency of stomach-Yin, lack of appetite vomiting, deficiency of both vital energy and Yin, restlessness and fever with thirst.
Raw tortoise plastron (Carapax et Plastrum Testudinis): nature and flavor: salty sweet, flat.1. " herbal classic ": " salty in the mouth, flat." 2. " not Lu ": " sweet, poisonous." 3. " property of medicine opinion ": " nontoxic." enter liver, kidney channel.1. " Thunder God is concocted property of medicine solution ": " enter the heart, spleen, liver three warps." 2. " Bencao Jingshu ": " enter meridian of Foot-SHAO YIN." return through: return liver, kidney, heart channel.Effect: YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone.Cure mainly: control deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spits blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones.
Rhizoma Coptidis (Rhizoma Coptidis): nature and flavor: hardship, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication.Cure mainly: for damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst.
The Flos Sophorae Immaturus: nature and flavor: sweet, flat, cold and cool.Gui Jing: return liver, large intestine channel.Effect: cooling blood for hemostasis, purging liver-fire.Cure mainly: for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, haematemesis, epistaxis, liver-heat conjunctival congestion, have a headache dizzy.
Herba Catharanthi Rosei: base is former: be Apocynaceae Vinca plant Herba Catharanthi Rosei, the herb of yellow Herba Catharanthi Rosei.Composition: contain indoles alkaloid more than 70 in Herba Catharanthi Rosei and plant, comprise vinblastine, vincristine, lochnericine, lochnericine, remove acetyl vindorosine, vincaleucoblastine, Changchun Buddhist nun are fixed, lochnerinine etc.Root is containing alkaloid, comprises that 9-methoxycorynantheidine., akuammicine, west, Changchun are fixed, lochnerivine, cavineine sulfate, sulphuric acid stay around western language alkali, and ammocalline, sulphuric acid group are around raw etc.Pharmacology: 1. antitumor action Herba Catharanthi Rosei contains vinblastine, vincristine, leurosine, leurosidine have obvious antitumor action.2. Antitumor Mechanism Herba Catharanthi Rosei antitumor action is directly relevant to the high-affinity of tubulin binding with medicine, and suppressing nucleic acid synthetic is its another mechanism.3., no matter blood pressure lowering and vasodilative effect catharanthus roseus total alkaloids gavage, intramuscular injection or quiet note all have hypotensive effect to anesthetized dog, expand in addition the effect of coronary vasodilator.4. the water extract of blood sugar lowering and effect for reducing blood fat this product leaf has the effect of the blood glucose of reduction to normal or alloxan diabetes rabbit and dog.Nature and flavor: hardship, cold, poisonous.Effect: detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.Cure mainly: for multiple cancerous protuberance, hypertension, carbuncle sore tumefacting virus, scalds.
Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Cure mainly: for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Trionyx sinensis Wiegmann climbs the tree: base is former: be the Herb of asclepiadaceae eye tree lotus plant eye tree lotus.Nature and flavor: " Guangxi conventional Chinese herbal medicine handbook among the people ": " sweet in the mouth, micro-acid, cold in nature, nontoxic." effect: removing heat from the lung and dissipating phlegm, removing pathogenic heat from blood and toxic substance from the body.Cure mainly: for lung-heat productive cough, hemoptysis, pertussis, infantile malnutrition, dysentery, furuncle furuncle and phyma, treating swelling and pain by traumatic injury, venom.
The Radix Angelicae Dahuricae: nature and flavor: pungent, temperature.Gui Jing: return stomach, large intestine, lung meridian.Effect: the cold expelling that induces sweat, wind-expelling pain-stopping, a surname's clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.Cure mainly: for headache due to common cold, supraorbital bone pain, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, toothache, leukorrhagia, skin infection swells and ache.
Qingre Jiedu Tang prescription provided by the invention is simple, compatibility science, and preparation is simple, product safety.Except this, excellent results of the present invention also shows:
1
,the effects such as this Qingre Jiedu Tang has heat-clearing and toxic substances removing, anti-inflammatory analgetic;
2
,all medicine synergism, play effect antibacterial and sterilization to suppuration type septicemia;
3, this Qingre Jiedu Tang curative effect is lasting, can long-term taking, have no side effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and test example, but protection domain is not limited to this.
embodiment 1the Qingre Jiedu Tang for the treatment of suppuration type septicemia, is prepared from by following bulk drugs: Folium Isatidis 25g, Radix Ophiopogonis 10g, Preparatum Glycyrrhizae 6g, Fructus Gardeniae 10g, Radix Scrophulariae 18g, Flos Lonicerae 20g, Radix Platycodonis 6g, Fructus Carotae 2g, Gypsum Fibrosum 12g, Herba Agerati Conyzoidis 4g, Rhizoma Anemarrhenae 12g, Radix Adenophorae (Radix Glehniae) 8g, raw tortoise plastron 12g, Rhizoma Coptidis 9g, Flos Sophorae Immaturus 5g, Herba Catharanthi Rosei 4g, Radix Angelicae Sinensis 8g, the Trionyx sinensis Wiegmann 2g that climbs the tree, Radix Angelicae Dahuricae 3g.
The preparation method of the Qingre Jiedu Tang of above-mentioned treatment suppuration type septicemia:
(1) raw tortoise plastron is used to sand parching to brown, immersed while hot in vinegar, after rinsing with clear water, dry, make vinegar Carapax et Plastrum Testudinis;
(2) first vinegar Carapax et Plastrum Testudinis is put into marmite, the decocting that adds 6 times of medical material gross weights boiled after 10 minutes, add again Gypsum Fibrosum to decoct 25 minutes, finally Folium Isatidis, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Gardeniae, Radix Adenophorae (Radix Glehniae), Radix Platycodonis, Fructus Carotae, Herba Agerati Conyzoidis, the Rhizoma Anemarrhenae, Rhizoma Coptidis, the Flos Sophorae Immaturus, Herba Catharanthi Rosei, Radix Angelicae Sinensis, Radix Scrophulariae, climb the tree Trionyx sinensis Wiegmann and Preparatum Glycyrrhizae are put into marmite, after being fried open, intense fire turns again 20 minutes at a simmer, supernatant is collected in filtration, leave recrement, recrement is watered intense fire again and is fried open, turn after at a simmer and leach supernatant, by twice supernatant mix homogeneously, stand-by;
(3) Flos Lonicerae decontamination is cleaned, dried, add 85% alcohol solvent of 5 times of Flos Lonicerae weight to soak 2 hours, be then heated to 70 DEG C, reflux, extract, 1 hour, filters to get filtrate, and repeats to extract three times, three filtrates are merged, be concentrated into the concentrated solution of original volume 1/3rd, for subsequent use;
(4) by above-mentioned steps (2) and (3) prepared supernatant and concentrated solution mix homogeneously, point install in the vial that the high temperature sterilize of 400ml crosses, sterilizing potting, stand-by.
The instructions of taking of Qingre Jiedu Tang of the present invention: Qingre Jiedu Tang is 7 days courses for the treatment of, takes 2-3 time (warm) every day, each 200ml.
embodiment 2the Qingre Jiedu Tang for the treatment of suppuration type septicemia, is prepared from by following bulk drugs: Folium Isatidis 40g, Radix Ophiopogonis 20g, Preparatum Glycyrrhizae 10g, Fructus Gardeniae 16g, Radix Scrophulariae 30g, Flos Lonicerae 40g, Radix Platycodonis 12g, Fructus Carotae 6g, Gypsum Fibrosum 25g, Herba Agerati Conyzoidis 9g, Rhizoma Anemarrhenae 25g, Radix Adenophorae (Radix Glehniae) 16g, raw tortoise plastron 20g, Rhizoma Coptidis 15g, Flos Sophorae Immaturus 15g, Herba Catharanthi Rosei 9g, Radix Angelicae Sinensis 16g, the Trionyx sinensis Wiegmann 5g that climbs the tree, Radix Angelicae Dahuricae 9g.
The preparation method of the Qingre Jiedu Tang of above-mentioned treatment suppuration type septicemia:
(1) raw tortoise plastron is used to sand parching to brown, immersed while hot in vinegar, after rinsing with clear water, dry, make vinegar Carapax et Plastrum Testudinis;
(2) first vinegar Carapax et Plastrum Testudinis is put into marmite, the decocting that adds 10 times of medical material gross weights boiled after 10 minutes, add again Gypsum Fibrosum to decoct 35 minutes, finally Folium Isatidis, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Gardeniae, Radix Adenophorae (Radix Glehniae), Radix Platycodonis, Fructus Carotae, Herba Agerati Conyzoidis, the Rhizoma Anemarrhenae, Rhizoma Coptidis, the Flos Sophorae Immaturus, Herba Catharanthi Rosei, Radix Angelicae Sinensis, Radix Scrophulariae, climb the tree Trionyx sinensis Wiegmann and Preparatum Glycyrrhizae are put into marmite, after being fried open, intense fire turns again 30 minutes at a simmer, supernatant is collected in filtration, leave recrement, recrement is watered intense fire again and is fried open, turn after at a simmer and leach supernatant, by twice supernatant mix homogeneously, stand-by;
(3) Flos Lonicerae decontamination is cleaned, dried, add 85% alcohol solvent of 9 times of Flos Lonicerae weight to soak 3 hours, be then heated to 80 DEG C, reflux, extract, 2 hours, filters to get filtrate, and repeats to extract three times, three filtrates are merged, be concentrated into the concentrated solution of original volume 1/3rd, for subsequent use;
(4) by above-mentioned steps (2) and (3) prepared supernatant and concentrated solution mix homogeneously, point install in the vial that the high temperature sterilize of 400ml crosses, sterilizing potting, stand-by.
The instructions of taking of Qingre Jiedu Tang of the present invention: Qingre Jiedu Tang is 7 days courses for the treatment of, takes 2-3 time (warm) every day, each 200ml.
Model case: xxx, man, 45 years old.Patient's cervical region suffers from " furuncle ", red, swollen, hot, bitterly, after 12 days, local redness spreads to palm enlargement, the multiple petechia of mucocutaneous appearance, body temperature rises to 39 DEG C, local operation incision and drainage, there is aversion to cold, high heat, headache that night, jaundice that health check-up next day Discover the patients is slight, hepatosplenomegaly, 39.5 DEG C of body temperature.WBC counts 22.1 × 109/L, and last diagnostic is suppuration type septicemia.
Take Qingre Jiedu Tang of the present invention, adopt every day 3 times (warm), each 200ml, 7 days is a course for the treatment of.Take after 3 days, spirit takes a turn for the better, and stable disease, continued to take after 2 courses for the treatment of, and patient's mental status is good,, jaundice and palm enlargement disappear, and hepatosplenomegaly is alleviated, and heart rate and temperature recovery are normal, take to 20 days, every ill symptoms disappears completely, and cervical region furuncle disappears, and patient's recovery from illness, has no recurrence.
embodiment 3the Qingre Jiedu Tang for the treatment of suppuration type septicemia, is prepared from by following bulk drugs: Folium Isatidis 30g, Radix Ophiopogonis 13g, Preparatum Glycyrrhizae 7g, Fructus Gardeniae 12g, Radix Scrophulariae 20g, Flos Lonicerae 25g, Radix Platycodonis 8g, Fructus Carotae 3g, Gypsum Fibrosum 15g, Herba Agerati Conyzoidis 5g, Rhizoma Anemarrhenae 15g, Radix Adenophorae (Radix Glehniae) 10g, raw tortoise plastron 15g, Rhizoma Coptidis 10g, Flos Sophorae Immaturus 7g, Herba Catharanthi Rosei 5g, Radix Angelicae Sinensis 10g, the Trionyx sinensis Wiegmann 3g that climbs the tree, Radix Angelicae Dahuricae 5g.The preparation method of the Qingre Jiedu Tang of above-mentioned treatment suppuration type septicemia:
(1) raw tortoise plastron is used to sand parching to brown, immersed while hot in vinegar, after rinsing with clear water, dry, make vinegar Carapax et Plastrum Testudinis;
(2) first vinegar Carapax et Plastrum Testudinis is put into marmite, the decocting that adds 7 times of medical material gross weights boiled after 10 minutes, add again Gypsum Fibrosum to decoct 30 minutes, finally Folium Isatidis, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Gardeniae, Radix Adenophorae (Radix Glehniae), Radix Platycodonis, Fructus Carotae, Herba Agerati Conyzoidis, the Rhizoma Anemarrhenae, Rhizoma Coptidis, the Flos Sophorae Immaturus, Herba Catharanthi Rosei, Radix Angelicae Sinensis, Radix Scrophulariae, climb the tree Trionyx sinensis Wiegmann and Preparatum Glycyrrhizae are put into marmite, after being fried open, intense fire turns again 25 minutes at a simmer, supernatant is collected in filtration, leave recrement, recrement is watered intense fire again and is fried open, turn after at a simmer and leach supernatant, by twice supernatant mix homogeneously, stand-by;
(3) Flos Lonicerae decontamination is cleaned, dry, add 85% alcohol solvent of 6 times of Flos Lonicerae weight to soak 2.5 hours, then be heated to 72 DEG C, reflux, extract, 1.5 hours, filters to get filtrate, repeat to extract three times, three filtrates are merged, be concentrated into the concentrated solution of original volume 1/3rd, for subsequent use;
(4) by above-mentioned steps (2) and (3) prepared supernatant and concentrated solution mix homogeneously, point install in the vial that the high temperature sterilize of 400ml crosses, sterilizing potting, stand-by.
The instructions of taking of Qingre Jiedu Tang of the present invention: Qingre Jiedu Tang is 7 days courses for the treatment of, takes 2-3 time (warm) every day, each 200ml.
embodiment 4the Qingre Jiedu Tang for the treatment of suppuration type septicemia, is prepared from by following bulk drugs: Folium Isatidis 35g, Radix Ophiopogonis 17g, Preparatum Glycyrrhizae 9g, Fructus Gardeniae 14g, Radix Scrophulariae 28g, Flos Lonicerae 35g, Radix Platycodonis 10g, Fructus Carotae 5g, Gypsum Fibrosum 22g, Herba Agerati Conyzoidis 8g, Rhizoma Anemarrhenae 22g, Radix Adenophorae (Radix Glehniae) 14g, raw tortoise plastron 17g, Rhizoma Coptidis 14g, Flos Sophorae Immaturus 13g, Herba Catharanthi Rosei 8g, Radix Angelicae Sinensis 14g, the Trionyx sinensis Wiegmann 4g that climbs the tree, Radix Angelicae Dahuricae 7g.
The preparation method of the Qingre Jiedu Tang of above-mentioned treatment suppuration type septicemia:
(1) raw tortoise plastron is used to sand parching to brown, immersed while hot in vinegar, after rinsing with clear water, dry, make vinegar Carapax et Plastrum Testudinis;
(2) first vinegar Carapax et Plastrum Testudinis is put into marmite, the decocting that adds 9 times of medical material gross weights boiled after 10 minutes, add again Gypsum Fibrosum to decoct 30 minutes, finally Folium Isatidis, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Gardeniae, Radix Adenophorae (Radix Glehniae), Radix Platycodonis, Fructus Carotae, Herba Agerati Conyzoidis, the Rhizoma Anemarrhenae, Rhizoma Coptidis, the Flos Sophorae Immaturus, Herba Catharanthi Rosei, Radix Angelicae Sinensis, Radix Scrophulariae, climb the tree Trionyx sinensis Wiegmann and Preparatum Glycyrrhizae are put into marmite, after being fried open, intense fire turns again 25 minutes at a simmer, supernatant is collected in filtration, leave recrement, recrement is watered intense fire again and is fried open, turn after at a simmer and leach supernatant, by twice supernatant mix homogeneously, stand-by;
(3) Flos Lonicerae decontamination is cleaned, dry, add 85% alcohol solvent of 8 times of Flos Lonicerae weight to soak 2.5 hours, then be heated to 78 DEG C, reflux, extract, 1.5 hours, filters to get filtrate, repeat to extract three times, three filtrates are merged, be concentrated into the concentrated solution of original volume 1/3rd, for subsequent use;
(4) by above-mentioned steps (2) and (3) prepared supernatant and concentrated solution mix homogeneously, point install in the vial that the high temperature sterilize of 400ml crosses, sterilizing potting, stand-by;
The instructions of taking of Qingre Jiedu Tang of the present invention: Qingre Jiedu Tang is 7 days courses for the treatment of, takes 2-3 time (warm) every day, each 200ml.
Model case: xxx, man, 21 years old.Patient is admitted to hospital because of nose face ache, and mound shape protuberance appears in the patient right side wing of nose, and labial surface buccal redness, with low grade fever.There is high heat, headache next day, 39 DEG C～41 DEG C of body temperature, patient's mind is indifferent, drowsiness, Ipsilateral eyelid and conjunctiva be without edema, and pulse is thin and delicate, rapid breathing, hepatosplenomegaly, and numeration of leukocyte is 23 × 109/L, blood antibacterial culturing is infection of staphylococcus aureus, is diagnosed as the concurrent suppuration type of boil of the nose septicemia.
Take Qingre Jiedu Tang of the present invention, adopt every day 3 times (warm), each 200ml, 7 days is a course for the treatment of.Take after 2 courses for the treatment of, patient respiratory hurriedly slows down, and heart rate is flat, high pyretolysis, headache and edema symptom alleviate, and boil of the nose symptom eases up, and inflammation alleviates, continue to take 2 courses for the treatment of, hemoculture is negative, boil of the nose resolution of symptoms, after by use Qingre Jiedu Tang of the present invention consolidate curative effect 10 days, patient's recovery from illness, has no recurrence.
embodiment 5the Qingre Jiedu Tang for the treatment of suppuration type septicemia, is prepared from by following bulk drugs: Folium Isatidis 32.5, and Radix Ophiopogonis 15, Preparatum Glycyrrhizae 8, Fructus Gardeniae 13, Radix Scrophulariae 24, Flos Lonicerae 30, Radix Platycodonis 9, Fructus Carotae 4, Gypsum Fibrosum 18.5, Herba Agerati Conyzoidis 6.5, the Rhizoma Anemarrhenae 18.5, Radix Adenophorae (Radix Glehniae) 12, raw tortoise plastron 16, Rhizoma Coptidis 12, the Flos Sophorae Immaturus 10, Herba Catharanthi Rosei 6.5, Radix Angelicae Sinensis 12, the Trionyx sinensis Wiegmann 3.5 that climbs the tree, the Radix Angelicae Dahuricae 6.
The preparation method of the Qingre Jiedu Tang of above-mentioned treatment suppuration type septicemia:
(1) raw tortoise plastron is used to sand parching to brown, immersed while hot in vinegar, after rinsing with clear water, dry, make vinegar Carapax et Plastrum Testudinis;
(2) first vinegar Carapax et Plastrum Testudinis is put into marmite, the decocting that adds 8 times of medical material gross weights boiled after 10 minutes, add again Gypsum Fibrosum to decoct 30 minutes, finally Folium Isatidis, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Gardeniae, Radix Adenophorae (Radix Glehniae), Radix Platycodonis, Fructus Carotae, Herba Agerati Conyzoidis, the Rhizoma Anemarrhenae, Rhizoma Coptidis, the Flos Sophorae Immaturus, Herba Catharanthi Rosei, Radix Angelicae Sinensis, Radix Scrophulariae, climb the tree Trionyx sinensis Wiegmann and Preparatum Glycyrrhizae are put into marmite, after being fried open, intense fire turns again 25 minutes at a simmer, supernatant is collected in filtration, leave recrement, recrement is watered intense fire again and is fried open, turn after at a simmer and leach supernatant, by twice supernatant mix homogeneously, stand-by.
(3) Flos Lonicerae decontamination is cleaned, dry, add 85% alcohol solvent of 7 times of Flos Lonicerae weight to soak 2.5 hours, then be heated to 75 DEG C, reflux, extract, 1.5 hours, filters to get filtrate, repeat to extract three times, three filtrates are merged, be concentrated into the concentrated solution of original volume 1/3rd, for subsequent use;
(4) by above-mentioned steps (2) and (3) prepared supernatant and concentrated solution mix homogeneously, point install in the vial that the high temperature sterilize of 400ml crosses, sterilizing potting, stand-by.
The instructions of taking of Qingre Jiedu Tang of the present invention: Qingre Jiedu Tang is 7 days courses for the treatment of, takes 2-3 time (warm) every day, each 200ml.
test example 1the clinical practice of the Qingre Jiedu Tang of embodiment 5 gained treatment suppuration type septicemia: 278 routine suppuration type septic patients are screened in 6 hospitals year February in March, 2010-2012, and wherein women's 116 examples, account for 41.7%, and male's 162 examples, account for 58.3%; Oldest is 58 years old, and minimal ages is 1 years old, and the mean age is 32.6 years old.Test 3 days before, carries out Continuous Observation to this crowd, records symptom and variation, be divided at random two groups, experimental group and matched group, experimental group is taken embodiment 5 products obtained therefroms, and matched group uses conventional dose (as gentamycin, amikacin, benzylpenicillin persister, benzylpencilline).Using method is: take every day 3 times (warm), each 200ml(adjusts to some extent depending on concrete condition), within 7 days, be a course for the treatment of.Curative effect situation criterion: cure: take three courses for the treatment of of this product, the transference cures such as aversion to cold, high heat, headache, tachycardia, rapid breathing, erythra, arthralgia, furuncle, inflammation, suppuration and hepatosplenomegaly; Effective: take three courses for the treatment of of this product, above-mentioned symptom alleviates to some extent, and health immune function increases; Invalid: take three courses for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 1-58 year suppuration type septic patient therapeutic outcomes
Therapeutic effect: cure 168 examples (80.8%), effective 30 examples (14.4%), invalid 10 examples (4.8%), total effective rate 95.2%.Successful is better than matched group.
Take after 30 days symptom and blood training situation is as shown in table 2.
Table 2:
The present invention selects the medical material compatibilities such as Folium Isatidis, Radix Ophiopogonis, Radix Scrophulariae, Flos Lonicerae, brings into play synergism between medicine, makes the treatment of suppuration type septicemia reach better effect.In side, Folium Isatidis, Flos Lonicerae, the Rhizoma Anemarrhenae, Gypsum Fibrosum, Rhizoma Coptidis, the Flos Sophorae Immaturus are mainly used in heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, blood cooling and ecchymoses removing; The Rhizoma Anemarrhenae is for YIN nourishing and the production of body fluid promoting, and lung moistening clears away heart-fire; Radix Scrophulariae, Radix Adenophorae (Radix Glehniae) and raw tortoise plastron are for nourishing YIN to relieve dryness.Multiple medicines use, not only reach the toxin of removing pathogen secretion in body the effect that suppresses germ reproduction, also improves the ability of the former bacterium of body disease-resistant simultaneously.Take after 30 days, more than 97% conditions of patients takes a turn for the better, and furuncle, inflammation malaise symptoms improve or disappear, and spirit, muscle power strengthen, and hepatosplenomegaly disappears, and in blood, pathogenic bacterium quantity significantly reduces.Experimental group patient took after 30 days, and effective percentage can reach 97%, and matched group is only 79%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (10)
1. suppuration type septicemia Qingre Jiedu Tang, is characterized in that, is mainly prepared from by following bulk drugs, is weight portion: Folium Isatidis 25-40, Radix Ophiopogonis 10-20, Preparatum Glycyrrhizae 6-10, Fructus Gardeniae 10-16, Radix Scrophulariae 18-30, Flos Lonicerae 20-40, Radix Platycodonis 6-12, Fructus Carotae 2-6, Gypsum Fibrosum 12-25, Herba Agerati Conyzoidis 4-9, Rhizoma Anemarrhenae 12-25, Radix Adenophorae (Radix Glehniae) 8-16, raw tortoise plastron 12-20, Rhizoma Coptidis 9-15, Flos Sophorae Immaturus 5-15, Herba Catharanthi Rosei 4-9, Radix Angelicae Sinensis 8-16, the Trionyx sinensis Wiegmann 2-5 that climbs the tree, Radix Angelicae Dahuricae 3-9.
2. Qingre Jiedu Tang as claimed in claim 1, is characterized in that, is mainly prepared from by following bulk drugs, is weight portion: Folium Isatidis 30-35, Radix Ophiopogonis 13-17, Preparatum Glycyrrhizae 7-9, Fructus Gardeniae 12-14, Radix Scrophulariae 20-28, Flos Lonicerae 25-35, Radix Platycodonis 8-10, Fructus Carotae 3-5, Gypsum Fibrosum 15-22, Herba Agerati Conyzoidis 5-8, Rhizoma Anemarrhenae 15-22, Radix Adenophorae (Radix Glehniae) 10-14, raw tortoise plastron 15-17, Rhizoma Coptidis 10-14, Flos Sophorae Immaturus 7-13, Herba Catharanthi Rosei 5-8, Radix Angelicae Sinensis 10-14, the Trionyx sinensis Wiegmann 3-4 that climbs the tree, Radix Angelicae Dahuricae 5-7.
3. Qingre Jiedu Tang as claimed in claim 1, is characterized in that, is mainly prepared from by following bulk drugs, is weight portion: Folium Isatidis 32.5, Radix Ophiopogonis 15, Preparatum Glycyrrhizae 8, Fructus Gardeniae 13, Radix Adenophorae (Radix Glehniae) 12, raw tortoise plastron 16, Rhizoma Coptidis 12, the Flos Sophorae Immaturus 10, Herba Catharanthi Rosei 6.5, Radix Angelicae Sinensis 12, the Trionyx sinensis Wiegmann 3.5 that climbs the tree, the Radix Angelicae Dahuricae 6.
4. the preparation method of the Qingre Jiedu Tang as described in as arbitrary in claim 1-3, is characterized in that, preparation process is as follows:
(1) raw tortoise plastron is used to sand parching to brown, immersed while hot in vinegar, after rinsing with clear water, dry, make vinegar Carapax et Plastrum Testudinis;
(2) first vinegar Carapax et Plastrum Testudinis is put into marmite, decoct with water after 10 minutes, add again Gypsum Fibrosum to decoct 25-35 minute (preferably 30 minutes), finally Folium Isatidis, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Gardeniae, Radix Adenophorae (Radix Glehniae), Radix Platycodonis, Fructus Carotae, Herba Agerati Conyzoidis, the Rhizoma Anemarrhenae, Rhizoma Coptidis, the Flos Sophorae Immaturus, Herba Catharanthi Rosei, Radix Angelicae Sinensis, Radix Scrophulariae, climb the tree Trionyx sinensis Wiegmann and Preparatum Glycyrrhizae are put into marmite, after being fried open, intense fire turns again 20-30 at a simmer minute (preferably 25 minutes), supernatant is collected in filtration, leave recrement, recrement is watered intense fire again and is fried open, turn after at a simmer and leach supernatant, by twice supernatant mix homogeneously, stand-by;
(3) Flos Lonicerae decontamination is cleaned, dry, add 85% alcohol solvent to soak 2-3 hour (preferably 2.5 hours), then heating and refluxing extraction 1-2 hour (preferably 1.5 hours), filter to get filtrate, repeat to extract three times, three filtrates are merged, be concentrated into the concentrated solution of original volume 1/3rd, for subsequent use;
(4) by above-mentioned steps (2) and (3) prepared supernatant and concentrated solution mix homogeneously, point install in the vial that the high temperature sterilize of 400ml crosses, sterilizing potting, stand-by.
5. the preparation method of Qingre Jiedu Tang as claimed in claim 4, is characterized in that, described step (2) is that vinegar Carapax et Plastrum Testudinis and Gypsum Fibrosum are smashed to pieces respectively, vinegar Carapax et Plastrum Testudinis and the Gypsum Fibrosum smashed to pieces that then pack tightly with gauze.
6. the preparation method of Qingre Jiedu Tang as claimed in claim 4, is characterized in that, described step (2) is that Preparatum Glycyrrhizae is contained in gauze bag, then decocts together with other medicines.
7. the preparation method of Qingre Jiedu Tang as claimed in claim 4, is characterized in that, in described step (2), amount of water is doubly (preferably 7-9 doubly, is more preferably 8 times) of 6-10 of medical material gross weight.
8. the preparation method of Qingre Jiedu Tang as claimed in claim 4, is characterized in that, in described step (3), the amount of 85% ethanol is doubly (preferably 6-8 doubly, is more preferably 7 times) of 5-9 of Flos Lonicerae weight.
9. the preparation method of Qingre Jiedu Tang according to claim 4, is characterized in that, in described step (3), the temperature of reflux is 70-80 DEG C (preferably 72-78, is more preferably 75 DEG C).
10. the application of the Qingre Jiedu Tang as described in as arbitrary in claim 1-3 in the time of the medicine of preparation treatment suppuration type septicemia.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623426A (en) * | 2008-07-09 | 2010-01-13 | 王光仁 | Traditional Chinese medicine for treating sepsis |
| CN103041025A (en) * | 2012-12-23 | 2013-04-17 | 徐化利 | Traditional Chinese medicine formula for treating septicemia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623426A (en) * | 2008-07-09 | 2010-01-13 | 王光仁 | Traditional Chinese medicine for treating sepsis |
| CN103041025A (en) * | 2012-12-23 | 2013-04-17 | 徐化利 | Traditional Chinese medicine formula for treating septicemia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105902621A (en) * | 2016-04-15 | 2016-08-31 | 宁波优美科新材料有限公司 | Drug for treatment of septicemia |
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