CN105902621A - Drug for treatment of septicemia - Google Patents

Drug for treatment of septicemia Download PDF

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Publication number
CN105902621A
CN105902621A CN201610233075.3A CN201610233075A CN105902621A CN 105902621 A CN105902621 A CN 105902621A CN 201610233075 A CN201610233075 A CN 201610233075A CN 105902621 A CN105902621 A CN 105902621A
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parts
septicemia
yunnan
ginseng
root
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吴斌
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Ningbo Youmeike New Material Co Ltd
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Ningbo Youmeike New Material Co Ltd
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Abstract

The invention relates to a drug for treatment of septicemia. The drug is prepared from the following raw herbal materials by weight: 20 parts of Melastoma dodecandrum, 6 parts of Orobanche yunnanensis, 15 parts of Asplenium prolongatum, 15 parts of Root of Common Triplostegia, 6 parts of fortune eupatorium flower, 9 parts of Tetraplodon mnioides, 15 parts of concentrated beef extract, 15 parts of Root of Szechwan-Yunnan Sanicle, 25 parts of ginseng, and 15 parts of common sage herb. According to the invention, the Melastoma dodecandrum can enter liver, kidney, spleen and lung meridians, and can activate blood circulation to stop bleeding; the Orobanche yunnanensis can tonify liver and kidney, and strengthen muscles and bones; the Asplenium prolongatum can clear away heat and remove dampness, activate blood circulation and dissolve stasis, relieve cough and reduce sputum; Root of Common Triplostegia can warm kidney and benefit qi, promote blood circulation and stop bleeding; the fortune eupatorium flower can resolve dampness and disperse qi; the Tetraplodon mnioides has tranquilizing and nerve soothing effects; the concentrated beef extract can tonify qi and benefit blood, tonify spleen and regulate the middle-energizer; the Root of Szechwan-Yunnan Sanicle can nourish lung and invigorating kidney; the ginseng can reinforce vital energy, tonify spleen and benefit lung, help produce saliva and slake thirst; and the common sage herb can clear heat and induce dieresis, cool blood and remove toxin. Combined use of the drugs can reach the efficacy of strengthening healthy qi to eliminate pathogens, nourishing yin and removing toxin, clearing heat and moistening lung. Clinical experiments prove that the drug provided by the invention can safely and effectively treat septicemia.

Description

A kind of medicine for treating septicemia
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine for treating septicemia.
Background technology
Septicemia is to be invaded blood circulation growth and breeding wherein by pathogenic bacteria, produces toxin and the whole body sexuality that causes Dye, easily occurs in the case of resistance of human body reduces.Mainly show as shiver with cold, high heat, toxemia synptom, fash, Arthralgia, hepatosplenomegaly, infectious shock, migrate venereal disease stove etc., most in the acute course of disease, state of an illness weight, poor prognosis, the most more Be further contemplated that septicemia be pathogenic bacteria and toxin thereof and metabolite enter blood flow after activate and discharge inflammatory mediators and cause A series of chain reaction process.This process, may result in dysfunction and the exhaustion of organs, the most clinically See pathogenic bacteria existence in body, also pay attention to immune response and the result of body.Know that inflammation is situated between Son has a complement component, arachidonic acid metabolite, tumor agent (TNF), interleukins (IL-s), interferon (IF-a), Platelet activating factor (PAF), macrophage Pro-inflammatory mediator (MPIC), protease, thromboxane and oxygen radical etc..
The traditional Chinese medical science: carbuncle complicated by septicemia, poison of deep-seated sore intruding inward, the evil inside fire attack of poison, septicopyemia streamer.The traditional Chinese medical science think empty in infection predominantly healthy tendency and Outer evil invasion is caused.Weakened body resistance is the outer evil essential condition invaded.Weakened body resistance can by eating and drinking without temperance, daily life is not normal, ferritic is not enough, or because of The sick void that causes, or malpractice, high just rushing down wound, or crosses sweat gas consumption impairment of yin, or serious burn, and the skin meat that collapses burns, or sore purulence blood, qi and blood Body fluid damages, or sore furuncle is squeezed wound, locally caused that stagnation of QI-blood, Ying Qi be not all right, carbuncle furuncle is lost and controlled after qi and blood dysfunction, or tumble injury Deng, just it is unequal to heresy, causes evil poison to cave in, the evolution process of a septicemia namely orthogonal process striven of heresy.
Clinical manifestation
Septicemia itself there is no special clinical manifestation, the performance seen when septicemia also seen in other acute infections, as Recurrent chilly is even shivered with cold, and Gao Re can be in tension and relaxation type or batch-type, and the fash based on petechia involves the pass in big joint Joint pain, slight hepatosplenomegaly, severe one can have mind to change, myocarditis, infectious shock, DIC, Respiratory Distress Syndrome(RDS) etc., respectively Plant different septicemia caused by pathogenic bacteria, have again its different clinical characters.
1. S. aureus L-forms septicemia, primary lesion is often skin furuncle carbuncle or wound infection, and minority system Abwehrkraft des Koepers is very poor Inside-hospital infection person, in its blood, germ is many from respiratory tract, and clinical onset is anxious, and its fash is petechia, nettle rash, pustular eruption and orangutan The variforms such as red heat sample fash, eye conjunctiva occur petechia is significant, and joint symptoms is obvious, sometimes red and swollen, But it is rare to suppurate.
2. form staph septicemia, is more common in inside-hospital infection, and after patient accepts broad-spectrum antibiotic therapy, this bacterium is easily formed Persister (has the bacterial strain of methicillin-resistant), and in respiratory tract and enteron aisle, this bacterium number showed increased, may result in general infection.
3. ennterococcal septicemia, enterococcus spp opportunistic infections bacterium, main parasitic is in enteron aisle and urinary system at ordinary times, clinical On show as urinary tract infections and endocarditis person is the most common, the most visible meningitis, osteomyelitis, pneumonia, enteritis and skin And soft tissue infection.
4. gram-negative bacteria septicemia, various pathogenic bacteria enters blood through different approaches, can cause complicated and diversified table Existing, these performances sometimes are covered by the symptom and sign of primary disease again, and sick front health status is poor, most with affecting body The protopathy of defense function, belongs to inside-hospital infection person more, shiver with cold, high heat, profuse sweating, and bimodal pattern of fever is more common, occasionally have in Three peak pattern of fever persons, this phenomenon is rare in the septicemia caused by other germs.
5. anaerobe septicemia, its pathogenic bacteria 80%～90% are bacteroides fragilises, the most still have streptococcus anaerobius, digest ball Bacterium and Bacillus perfringens etc., intrusion feature takes second place based on intestines and stomach and female genital tract, bedsore, ulcer, clinical manifestation with Aerobic bacteria septicemia is similar, and it is distinctive is presented with:
A incidence of jaundice is up to 10%～40%, may directly act on liver and Bacillus perfringens with the endotoxin of bacteroid A toxin cause haemocylolysis relevant;
B local lesion secretion has special putrefactive odor,
C easily causes septic thrombophlebitis and thoracic cavity, lung, the internal membrane of heart, abdominal cavity, liver, the migrating property of brain and Bones and joints etc. Focus, this is more common at bacteroides fragilis and streptococcus anaerobius septicemia,
D may occur in which more serious hemolytic anemia and kidney failure in Bacillus perfringens septicemia, and local is migrated in venereal disease stove to be had Gas is formed, and anaerobic bacteria is often and aerobic bacteria cooperatively causes the bacterium septicemia that pluralizes, and prognosis is dangerous.
6. mycotic septicemia, typically occurs in the course of disease later stage of serious primary disease, has a liver complaint often, ephrosis, glycosuria The chronic patient of disease, blood disease or malignant tumour or serious burn, openheart surgery, the patient of organ transplant.
The diagnosis of this disease relies primarily on laboratory examination
1. blood picture: total white blood cells significantly increases, generally 10～30 × 10^9/L, neutrophil leucocyte is many more than 0.8, and core is left Move, wherein have toxic granules.Critically ill patient red blood cell reduces with hemoglobin.
2. etiological examination: blood culture has pathogenic bacteria growth to be the important evidence making a definite diagnosis septicemia, carries out susceptibility examination simultaneously Test selecting effective antibacterials significant.Blood culture should take blood when the high heat of shiver with cold, used antibiosis before the treatment Element person then should avoid the blood sampling of medicine peak concentration time, so can improve positive rate.Once cultivate and not necessarily obtain positive findings, Typically answering censorship more than three times, blood drawing is no less than 10ml every time.It is higher that marrow cultivates relatively blood culture with positive bacteria rate.The most desirable focus is divided Secretion and excreta, as fester, phlegm, urine, excrement, hydrothorax, ascites etc. cultivate pathogen.
3. serological test:
(1) LTOY LALT: the endotoxin of gramnegative bacterium in serum can be detected, contribute to judging gram negative bacilli sepsis Disease；
(2) self bacterium serum agglutination test: the aggegation that the bacterium obtained with Blood of Patients cultivation makees in antigen detection patients serum resists Body.Have ready conditions pathogenic bacteria growth in blood culture and when cannot determine whether pathogen, this test can be made, have certain reference significance.
Drug therapy 1. endotoxin monoclonal antibody: this antibody-like can neutralize the virulent gene of creotoxin, stops itself and target The combination of cell, thus suppress the synthesis of virulence factor and release and play protective effect.Resist with Escherichia coli J5 mutant strain The mouse type of former preparation and human-like anti-lipid A IgM monoclonal antibody；2. immunoglobulin (Ig): beta Globulin, said preparation contains high price Specific IgG, IgM and the IgA antibody of antiendotoxin core determinant, strives for using in septicemia occurs 24 hours.Use Recombinant human interleukin I receptor antagonist treatment septic syndrome patient, can significantly improve septicemia and merge MSOF and have The life span of multiple high-risk Prognostic Factors patients.3. cortex hormone of aadrenaline, can septic patient use adrenal cortex Hormone is the most undetermined.Generally believe that short-period used suitable dose can produce inhibitory action to acute inflammation.At activation by lipopolysaccharide Apply before mononuclear macrophage, then can substantially reduce the generation of cell factor.Therefore it should be noted that the opportunity of use, consumption and the course for the treatment of. 4. antagonism inflammatory mediator and the medicine of scavenging activated oxygen, as antiendotoxin monoclonal antibody, IL-1 receptor antagonist, de-guanosine deaminase press down Preparation etc..5. treatment by Chinese herbs septicemia can use traditional Chinese medical herbal treatment, and effectiveness comparison is preferable.Simultaneously it should be noted that diet and life are practised Used.
Medicinal material involved in the present invention all seen from be recorded in " China book on Chinese herbal medicine ".
Summary of the invention
It is desirable to provide a kind of medicine for treating septicemia, by selecting suitable medicinal material and proportioning thereof, reach To the purpose safely and effectively curing septicemia.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of medicine for treating septicemia, it is characterised in that it is to be prepared from by the raw medicinal material of following weight proportion: PUDIJIN 20 parts, Yunnan broomrape 6 parts, determine grass roots 15 parts, all draw 15 parts, fortune eupatorium flower 6 parts, special 9 parts of problem, concentrated beef extract 15 parts, little black Medicine 15 parts, ginseng 25 parts, meal spoon grass 15 parts.
Illustrate the method have the benefit that below in conjunction with theories of Chinese materia medica
It has been recognised by the inventors that the basic pathogenesis of septicemia is the invasion and attack of external cause temperature poison, outside internal cause healthy tendency virtual loss can not be driven, just it is being unequal to heresy, Heat symptoms caused by an exopathgen are arrogant, and heat poison is full of in table, and visitor, in ying blood, enters to alter channels and collaterals, enters sunken internal organs, and in table, three is burnt all sick.Initial stage, criminal defended, and heating is disliked Cold.Heat poisons fire, and the progress of disease causes excessive heat in the interior,interior-heat being overabundant rapidly.Heresy enters ying blood, then see high fever, coma, close the cards such as de-, hemorrhage, heat poison stream Note is then shown in multiple abscess.This enters blood breeding and causes the serious poisoning symptom of whole body and to migrate focus consistent with germ.This disease complexity is many The clinical manifestation that the danger card become, card of endangering are grown thickly, i.e. traditional Chinese medicine are so-called, and " poison enters the heart and then goes into a coma, and enters liver then convulsion and faints, enters lung then Breathing heavily and cough, enter the kidney dark brothers of then mesh cold, enter six internal organs and respectively become end, seven evils are folded sees." principle of reatment pay attention to eliminating evil while, Focus on righting again.
The present invention uses: PUDIJIN enters liver,kidney,spleen, lung four warp, and promoting blood circulation and hemostasis is clearing heat and detoxicating；Yunnan broomrape filling liver kidney, by force Muscles and bones；Determine grass roots removing damp-heat, promoting blood circulation and removing blood stasis, relieving cough and reducing sputum；All draw temperature kidney benefit gas, promoting blood circulation and hemostasis；Fortune eupatorium flower dampness elimination a surname's gas；Ask The special tranquilizing and allaying excitement of topic；Concentrated beef extract invigorating qi and benefiting blood, in invigorating the spleen peace；Szechwan-Yunnan sanicle root is invigorated the lung and the kidney；Ginseng reinforces vital energy, and reinforces the spleen to benefit the lung, raw Quench the thirst in Tianjin；Meal spoon grass reducing fever and causing diuresis；Cool blood；Removing toxic substances.All medicines share, and play strengthening vital QI to eliminate pathogenic factors, enriching yin removing toxic substances, the merit of clearing heat and moistening lung altogether.
Below in conjunction with clinical laboratory data beneficial effects of the present invention is described:
1, physical data
Inventor collects 64 example septic patients between 2011 08 month-2013 years 06 month altogether.It is randomly divided into: treatment group 32 example, right According to organizing 32 examples.Man's 42 examples, female 22 example, age 28～81 years old, 49.1 ± 16.4 years old mean age.Two groups of sexes, age, courses of disease etc. There was no significant difference for data, has comparativity.
Diagnostic criteria:
1. focal infection history.
2. onset is anxious, high heat of shivering, body temperature fluctuation are big, perspires more, and ordinary circumstance Progressive symmetric erythrokeratodermia exhaustion can have big arthritis Bitterly.Poisoning symptom severe patient can have delirium, goes into a coma and suffer a shock.
3. liver, splenomegaly, mucocutaneous petechiae, can there be jaundice, anaemia.
4. venereal disease stove (being more common in pyococcus, particularly S. aureus L-forms infects) is migrated.
5. total white blood cells and neutrophilic leukocytosis, eosinophil reduces or disappears, severe infections or some leather orchid Family name negative microbial infections person, total white blood cells can reduce.
6. bacterium looked for by petechiae, ecchymosis smear.
7. blood or marrow cultivate the positive, and the person of decontaminating can make a definite diagnosis.
1. inclusive criteria meets this disease diagnostic criteria；The most all patients have eat less, few dynamic, heating or body temperature do not rise Clinical manifestation；3. without severe complication；4. be a cup too low disease.
1. exclusion standard to drugs composition allergy, has serious adverse reaction；2. there are severe cardiac, liver, kidney etc. important dirty Device dysfunction person；3. gestation or women breast-feeding their children, allergic constitution person；4. merge during treating and use other treatment septicemia Medicine person, not by regulation pill taker.
2, methods for the treatment of
Treatment group is administered orally the capsule that the present invention prepares according to specific embodiment 3, three times a day.Treat 3 months.
Control group is administered orally ornidazole capsule, 0.25g/ time, 3 times/d；Clindamycin, 150mg/ time, 4 times/d.Treat 3 Month.
3, criterion of therapeutical effect and treatment results
3.1 criterion of therapeutical effect
The most effective: clinical symptom disappearance, fever time is less than 3 days, and blood leukocytes and classification recover normal, blood and the training of marrow bacterium Support and turn out cloudy；
The most effective: clinical symptoms take a turn for the better, fever time is more than 3 days, and blood leukocytes and classification take a turn for the better, blood and marrow Bacteria Culture sun Property or turn out cloudy；
The most invalid: clinical symptoms are without taking a turn for the better, and blood Bacteria Culture still has pathogenic bacteria, or patient is dead because of septicemia.
3.2 treatment statisticses are shown in Table 1.
1 liang of table group comparitive study
Group n Effective Effectively Invalid Total effective rate (%) Obvious adverse reaction example
Treatment group 32 5 21 6 81.25% 0
Control group 32 7 9 16 50% 0
Visible, septicemia can safely and effectively be treated by the medicine that the present invention prepares, and cure rate is high.
Detailed description of the invention
In order to be more fully understood that and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Weigh: PUDIJIN 20 grams, Yunnan broomrape 6 grams, determine grass roots 15 grams, all draw 15 grams, fortune eupatorium flower 6 grams, problem special 9 grams, concentrated beef extract 15 grams, szechwan-Yunnan sanicle root 15 grams, ginseng 25 grams, meal spoon grass 15 grams；Add 8 times amount water, decoct 1.5 hours, filter；Filter residue adds 6 times amount water, Decoct 1 hour, filter；Merging filtrate, is concentrated into 120 grams, must meet the decoction of one day consumption of adult normal.
For treating septicemia.Oral, the most once.
Embodiment 2
Weigh: PUDIJIN 20 grams, Yunnan broomrape 6 grams, determine grass roots 15 grams, all draw 15 grams, fortune eupatorium flower 6 grams, problem special 9 grams, concentrated beef extract 15 grams, szechwan-Yunnan sanicle root 15 grams, ginseng 25 grams, meal spoon grass 15 grams；Add 10 times amount water, decoct 2 hours, filter；Filter residue adds 8 times amount water, Decoct 1.5 hours, filter；Merging filtrate, concentrates, and is dried, and packaging must meet the powder of one day consumption of adult normal.
For treating septicemia.Oral, every bu is taken for twice sooner or later.
Embodiment 3
Weigh: PUDIJIN 20 grams, Yunnan broomrape 6 grams, determine grass roots 15 grams, all draw 15 grams, fortune eupatorium flower 6 grams, problem special 9 grams, concentrated beef extract 15 grams, szechwan-Yunnan sanicle root 15 grams, ginseng 25 grams, meal spoon grass 15 grams；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge and decoct Liquid, concentrates, and is dried, and loads capsule shells, must meet the capsule of one day consumption of adult normal.
For treating septicemia.Oral, every bu morning, noon and afternoon take for three times.

Claims (4)

1. the medicine being used for treating septicemia, it is characterised in that it is by the raw medicinal material preparation of following weight proportion Become: PUDIJIN 20 parts, Yunnan broomrape 6 parts, determine grass roots 15 parts, all draw 15 parts, fortune eupatorium flower 6 parts, problem spy 9 parts, concentrated beef extract 15 parts, little Black powder 15 parts, ginseng 25 parts, meal spoon grass 15 parts.
2. the medicine for treating septicemia as claimed in claim 1, it is characterised in that its preparation method is: weigh: floor file Brocade 20 parts, Yunnan broomrape 6 parts, determine grass roots 15 parts, all draw 15 parts, fortune eupatorium flower 6 parts, problem spy 9 parts, concentrated beef extract 15 parts, szechwan-Yunnan sanicle root 15 Part, ginseng 25 parts, meal spoon grass 15 parts；Add 8 times amount water, decoct 1.5 hours, filter；Filter residue adds 6 times amount water, decocts 1 hour, mistake Filter；Merging filtrate, is concentrated into 120 parts, obtains decoction；Above-mentioned part each means weight portion.
3. the medicine for treating septicemia as claimed in claim 1, it is characterised in that its preparation method is: weigh: floor file Brocade 20 parts, Yunnan broomrape 6 parts, determine grass roots 15 parts, all draw 15 parts, fortune eupatorium flower 6 parts, problem spy 9 parts, concentrated beef extract 15 parts, szechwan-Yunnan sanicle root 15 Part, ginseng 25 parts, meal spoon grass 15 parts；Add 10 times amount water, decoct 2 hours, filter；Filter residue adds 8 times amount water, decocts 1.5 hours, mistake Filter；Merging filtrate, concentrates, and is dried, and packaging obtains powder；Above-mentioned part each means weight portion.
4. the medicine for treating septicemia as claimed in claim 1, it is characterised in that its preparation method is: weigh: floor file Brocade 20 parts, Yunnan broomrape 6 parts, determine grass roots 15 parts, all draw 15 parts, fortune eupatorium flower 6 parts, problem spy 9 parts, concentrated beef extract 15 parts, szechwan-Yunnan sanicle root 15 Part, ginseng 25 parts, meal spoon grass 15 parts；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentrate, be dried, Load capsule shells, obtain capsule；Above-mentioned part each means weight portion.
CN201610233075.3A 2016-04-15 2016-04-15 Drug for treatment of septicemia Pending CN105902621A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101574421A (en) * 2009-06-22 2009-11-11 王启金 Medicament for treating leukemia and septicemia
CN101623473A (en) * 2008-07-09 2010-01-13 王光仁 Traditional Chinese medicine for treating sepsis
CN101623426A (en) * 2008-07-09 2010-01-13 王光仁 Traditional Chinese medicine for treating sepsis
CN102018910A (en) * 2009-09-23 2011-04-20 蒲灵珍 Chinese medicinal preparation for treating septicemia
CN104189451A (en) * 2014-08-25 2014-12-10 李德才 Heat-clearing and toxicity-removing soup for suppurated-type septicemia and preparation method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101623473A (en) * 2008-07-09 2010-01-13 王光仁 Traditional Chinese medicine for treating sepsis
CN101623426A (en) * 2008-07-09 2010-01-13 王光仁 Traditional Chinese medicine for treating sepsis
CN101574421A (en) * 2009-06-22 2009-11-11 王启金 Medicament for treating leukemia and septicemia
CN102018910A (en) * 2009-09-23 2011-04-20 蒲灵珍 Chinese medicinal preparation for treating septicemia
CN104189451A (en) * 2014-08-25 2014-12-10 李德才 Heat-clearing and toxicity-removing soup for suppurated-type septicemia and preparation method

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