CN1200289A - Sanhua xietingye liquid medicine for treating diarrhea made of three flowers - Google Patents
Sanhua xietingye liquid medicine for treating diarrhea made of three flowers Download PDFInfo
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- CN1200289A CN1200289A CN 97111338 CN97111338A CN1200289A CN 1200289 A CN1200289 A CN 1200289A CN 97111338 CN97111338 CN 97111338 CN 97111338 A CN97111338 A CN 97111338A CN 1200289 A CN1200289 A CN 1200289A
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Abstract
A medicinal liquid for stopping diarrhea is prepd. by conventional method from lonicera flower, sophora flower, safflower, flavesent sophra root, rhizoma coptidis, cortex phellodendri, radix paeoniae alba, rhizoma polygonati, mume fruit, radix pulsatillue, licorice etc. It possesses the functions of resisting intestine, pathogenic bacteir,aimproving immunity so as to enhance the ability of resisting disease.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of infectious diarrhea, specifically a kind of is the Sanhua xietingye liquid medicine for treating diarrhea made of three flowers of feedstock production with Chinese medicine.
Infectious diarrhea is modal intestinal infection disease, is more common in pediatric patient especially.In the prior art, generally use antibiotics and antiviral Western medicine with control infection, venous transfusion reaches therapeutic purposes with measures such as correct dehydration acidosis and oral ORS prevention dehydrations.But antibacterial, virus causing disease or newfound pathogenic antigens type increase year by year owing to no matter cause in the pathogen of infectious diarrhea in recent years, and wherein Resistant strain also increases.For serious symptom and intractable, chronic, persisting type diarrhoea, adopt antibiotic therapy, often need the long course of treatment.Even two or more antibiotics and usefulness, not only cause the intestinal microbial population disorder easily, and the side effect of infection Western medicine also can be easy to occur because of the course of treatment is long.Then, secular diarrhoea causes patient's malnutrition, and body constitution descends, and outer infection of Secondary cases digestive tract will be following all also, cause the patient in time not treat, and have a strong impact on life and health.
The object of the present invention is to provide a kind ofly have that bowel relieving is purged heat, effect that heat-clearing and toxic substances removing, emergency relax contraction, invigorating the spleen and regulating the stomach, and effective infection suppresses pathogenic bacteria, improves immunologic function, the Sanhua xietingye liquid medicine for treating diarrhea made of three flowers of raising body resistance against diseases.
Solution of the present invention is based on infectious diarrhea pathogeny and Therapeutic Principle, and traditional tcm theory, and choosing the Chinese medicine medicine is raw material, is prepared from according to the conventional formulation method.Raw material of the present invention and composition weight percentage composition thereof are:
Flos Lonicerae 8-12% Flos Sophorae 8-12% Flos Carthami 2-6% Rhizoma Coptidis 8-1 2%
Cortex Phellodendri 11-17% Radix Paeoniae Alba 8-12% Rhizoma Polygonati 8-12% Fructus Mume 8-12%
Radix Glycyrrhizae 8-12% Radix Pulsatillae 2-6% Radix Sophorae Flavescentis 5-9%
Wherein, the Flos Lonicerae in the described raw material can replace with in Radix Isatidis, Folium Isatidis, Fructus Forsythiae, Indigo Naturalis, the Caulis Sargentodoxae any, and it is constant that it forms weight percentage; Flos Sophorae in the described raw material can replace with in Radix Rubiae, Cacumen Platycladi, Rhizoma Imperatae, coupling joint, the Folium Artemisiae Argyi any, and it is constant that it forms weight percentage; Flos Carthami in the described raw material can replace with in Radix Salviae Miltiorrhizae, Herba Leonuri, Rhizoma Curcumae Longae, Hirudo, the Oletum Trogopterori any, and it is constant that it forms weight percentage.
Acute toxicity testing result of the present invention: Sanhua xietingye liquid medicine for treating diarrhea made of three flowers once irritates stomach 30g (crude drug)/kg for mice, does not measure LD50.With mouse stomach maximum volume 30ml/kg and medicine Cmax 2g (crude drug)/ml, successive administration is 3 times in one day, observes continuously 7 days, and total dosage 180g/kg is equivalent to 64 times of clinical consumption.Proof this product toxicity is very low, safe in utilization.
Long term toxicity test result of the present invention: Sanhua xietingye liquid medicine for treating diarrhea made of three flowers with 3g/kg and two dosage of 6g/kg to two groups of rat oral gavages, once a day, in 10 weeks of successive administration, rat generally shows (activity, sign, feed, amount of drinking water, body weight etc.), electrocardiogram, peripheral hemogram, serum biochemistry check, histopathologic examination no significant difference and toxic reaction all and between the matched group.Show that Sanhua xietingye liquid medicine for treating diarrhea made of three flowers toxicity is very low.
Confirm that through pharmacological experiment study medicine of the present invention has very strong resistance to common pathogenic entero becteria, especially to Fo Shi dysentery bacterium and Salmonella typhimurium.In addition Bacillus typhi, staphylococcus aureus, escherichia coli etc. all had in various degree antibacterial action.Autoimmune mechanism by regulating body to be improving immunologic function, thereby improves the resistance against diseases of body.The ileum autonomic movement is obviously suppressed, reduces its tonicity, and contraction frequency slows down.The present invention also has the function of part electrolyte supplement and moisture in addition.
The present invention uses through clinical 112 routine patients, obtains significant curative effect 41 examples, has 105 examples and reaches therapeutic effect, and total effective rate is 93.75%.And in western medicine matched group 54 examples, only have 8 examples to obtain significant curative effect, and its treatment responder 44 examples, total effective rate is 81.48%.Clinical effectiveness shows that the present invention obviously is better than western medicine.
The present invention also will be described in further detail in conjunction with the embodiments:
Embodiment one:
A kind of Sanhua xietingye liquid medicine for treating diarrhea made of three flowers, be by following raw materials in percentage by weight routinely formulation method be prepared from: Flos Lonicerae 9%, Flos Sophorae 9%, Flos Carthami 2%, Rhizoma Coptidis 11%, Cortex Phellodendri 16%, the Radix Paeoniae Alba 12%, Rhizoma Polygonati 9%, Fructus Mume 11%, Radix Glycyrrhizae 10%, the Radix Pulsatillae 4%, Radix Sophorae Flavescentis 7%.
Embodiment two
A kind of Sanhua xietingye liquid medicine for treating diarrhea made of three flowers is to be prepared from according to the conventional formulation method by following raw materials in percentage by weight: Radix Isatidis 10%, Radix Rubiae 10%, Radix Salviae Miltiorrhizae 6%, Rhizoma Coptidis 12%, Cortex Phellodendri 14%, the Radix Paeoniae Alba 10%, Rhizoma Polygonati 11%, Fructus Mume 8%, day grass 8%, the Radix Pulsatillae 3%, Millefolium ginseng 8%.
Embodiment three
A kind of Sanhua xietingye liquid medicine for treating diarrhea made of three flowers is to be prepared from according to the conventional formulation method by following raw materials in percentage by weight: Folium Isatidis 8%, Cacumen Platycladi 11%, Herba Leonuri 5%, Rhizoma Coptidis 10%, Cortex Phellodendri 15%, the Radix Paeoniae Alba 9%, Rhizoma Polygonati 12%, Fructus Mume 9%, Radix Glycyrrhizae 10%, the Radix Pulsatillae 6%, Radix Sophorae Flavescentis 5%.
Embodiment four
A kind of Sanhua xietingye liquid medicine for treating diarrhea made of three flowers be by following raw materials in percentage by weight routinely formulation method be prepared from: Fructus Forsythiae 12%, Rhizoma Imperatae 8%, Rhizoma Curcumae Longae 3%, Rhizoma Coptidis 9%, Cortex Phellodendri 12%, the Radix Paeoniae Alba 11%, Rhizoma Polygonati 10%, Fructus Mume 10%, Radix Glycyrrhizae 12%, the Radix Pulsatillae 5%, Radix Sophorae Flavescentis 8%.
Embodiment five:
A kind of Sanhua xietingye liquid medicine for treating diarrhea made of three flowers, be by following raw materials in percentage by weight routinely formulation method be prepared from: Indigo Naturalis 11%, Nodus Nelumbinis Rhizomatis 9%, Hirudo 4%, Rhizoma Coptidis 11%, Cortex Phellodendri 13%, the Radix Paeoniae Alba 10%, Rhizoma Polygonati 8%, Fructus Mume 11%, Radix Glycyrrhizae 9%, the Radix Pulsatillae 5%, Radix Sophorae Flavescentis 9%.
Embodiment six:
A kind of Sanhua xietingye liquid medicine for treating diarrhea made of three flowers be by following raw materials in percentage by weight routinely formulation method be prepared from: Caulis Sargentodoxae 9%, Folium Artemisiae Argyi 12%, Oletum Trogopterori 4%, Rhizoma Coptidis 8%, Cortex Phellodendri 17%, the Radix Paeoniae Alba 8%, Rhizoma Polygonati 9%, Fructus Mume 12%, Radix Glycyrrhizae 11%, the Radix Pulsatillae 4%, Radix Sophorae Flavescentis 6%.
Claims (4)
1, a kind of Sanhua xietingye liquid medicine for treating diarrhea made of three flowers, it is characterized in that it by following raw materials in percentage by weight routinely formulation method be prepared from:
Flos Lonicerae 8-12% Flos Sophorae 8-12% Flos Carthami 2-6% Rhizoma Coptidis 8-12%
Cortex Phellodendri 11-17% Radix Paeoniae Alba 8-12% Rhizoma Polygonati 8-12% Fructus Mume 8-12%
Radix Pulsatillae 2-6% Radix Glycyrrhizae 8-12% Radix Sophorae Flavescentis 5-9%
2, Sanhua xietingye liquid medicine for treating diarrhea made of three flowers as claimed in claim 1 is characterized in that the Flos Lonicerae in the described raw material can replace with in Radix Isatidis, Folium Isatidis, Fructus Forsythiae, Indigo Naturalis, the Caulis Sargentodoxae any, and it is constant that it forms weight percentage.
3, Sanhua xietingye liquid medicine for treating diarrhea made of three flowers as claimed in claim 1 is characterized in that the Flos Sophorae in the described raw material can replace with in Radix Rubiae, Cacumen Platycladi, Rhizoma Imperatae, Nodus Nelumbinis Rhizomatis, the Folium Artemisiae Argyi any, and it is constant that it forms weight percentage.
4, Sanhua xietingye liquid medicine for treating diarrhea made of three flowers as claimed in claim 1 is characterized in that the Flos Carthami in the described raw material can replace with in Radix Salviae Miltiorrhizae, Herba Leonuri, Rhizoma Curcumae Longae, Hirudo, the Oletum Trogopterori any, and it is constant that it forms weight percentage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97111338A CN1050762C (en) | 1997-05-24 | 1997-05-24 | Sanhua xietingye liquid medicine for treating diarrhea made of three flowers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97111338A CN1050762C (en) | 1997-05-24 | 1997-05-24 | Sanhua xietingye liquid medicine for treating diarrhea made of three flowers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1200289A true CN1200289A (en) | 1998-12-02 |
| CN1050762C CN1050762C (en) | 2000-03-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97111338A Expired - Fee Related CN1050762C (en) | 1997-05-24 | 1997-05-24 | Sanhua xietingye liquid medicine for treating diarrhea made of three flowers |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358549C (en) * | 2005-11-07 | 2008-01-02 | 惠州九惠药业有限公司 | Diarrhea treating chinese medicine composition |
| CN104800654A (en) * | 2015-05-13 | 2015-07-29 | 龚灿锋 | Traditional Chinese medicine for treating infection of digestive canal |
| CN115068554A (en) * | 2022-07-12 | 2022-09-20 | 新希望六和股份有限公司 | Antibiotic substitute and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121422A (en) * | 1994-09-19 | 1996-05-01 | 田振国 | Medicine for curing chronic colitis |
-
1997
- 1997-05-24 CN CN97111338A patent/CN1050762C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358549C (en) * | 2005-11-07 | 2008-01-02 | 惠州九惠药业有限公司 | Diarrhea treating chinese medicine composition |
| CN104800654A (en) * | 2015-05-13 | 2015-07-29 | 龚灿锋 | Traditional Chinese medicine for treating infection of digestive canal |
| CN115068554A (en) * | 2022-07-12 | 2022-09-20 | 新希望六和股份有限公司 | Antibiotic substitute and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1050762C (en) | 2000-03-29 |
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