CN103071104B - Traditional Chinese medicine compound preparation for treating middle-advanced pancreatic cancer - Google Patents
Traditional Chinese medicine compound preparation for treating middle-advanced pancreatic cancer Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating a middle-advanced pancreatic cancer. The preparation is characterized in that the preparation comprises the following raw medicinal materials in proportion by weight: hedyotis diffusa, scorpion, gecko, rhizoma amorphophalli, euchresta japonica, crude rhubarb, fiveleaf gynostemma herb and amomum cardamomum; the medicinal materials are taken according to the proportioning and mixed uniformly; the mixed traditional Chinese medicinal materials are added to a multi-kinetic extractor, soaked for half an hour, decocted, and then concentrated into paste; and the paste, dextrin and powdered sugar at a ratio of 1:1:3 are poured into a stirring machine for stirring, then prepared into uniform 10-14-mesh particles in a pelletizer, and dried in a 60-80 DEG C environment.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation, specifically a kind of compound Chinese medicinal preparation of advanced pancreatic cancer.
Background technology
Cancer of pancreas is that grade malignancy is high, one of tumor that prognosis is the poorest, characteristics of incidence: the course of disease is short, progress is fast, mortality rate is high; Median survival interval about 6 months.Cancer of pancreas lacks typical clinical manifestations in early days, and aggressive is strong; Within overall 5 years, survival rate is less than 5%, and the annual rate of depositing is less than 20%.In recent years in the world, the sickness rate of cancer of pancreas raises year by year, rises to the 5th at the mortality rate of China's cancer of pancreas by the original the tenth.Be at present Comprehensive Treatment to the common recognition for the treatment of of pancreatic cancer, first-selected treatment is still excision, but Resection Rate is very low, is reported as 8% ~ 30%, and on average about 15%.Can still need to be aided with chemotherapy and/or radiotherapy and other treatment after the person's of excision excision, but late result improves very micro-.Majority can not the person of excision, adopts the Comprehensive Treatments such as chemicotherapy, naturopathy, Biotherapeutics (comprising gene, immunization therapy), endocrine therapy, but annually deposits rate still very low (being less than 20%).Chinese medicine cancer of pancreas has caused the attention of more and more doctor, Comprehensive Treatment based on Chinese medicine, reasonable coordination uses less intense chemotherapy or radiotherapy, biologic treatment, laser, freezing and radio-frequency (RF) therapy etc., the evolution of tumor can be controlled to greatest extent, alleviate patient's misery, improve quality of life of patients, extend patients ' lives.The each doctor of modern Chinese medicine is roughly divided into cancer of pancreas pathogenesis understanding based on insufficiency of the spleen or be main dialectical treatmert two kinds of main points of view with the domination of pathogen (expectorant, wet, hot, malicious etc.), and the clinical rule for the treatment of is different with method for the treatment of, though there is certain curative effect, therapeutic effect is all undesirable.What does is the rule for the treatment of of Chinese traditional treatment cancer of pancreas actually? should Selection drug to attack heresy? does is righting main? which kind of Chinese medicine or prescription the most effective? what does is effective Chinese medicine onset mechanism? more than be the problem awaiting research further.
Through retrieval, CN1428159 discloses a kind of patent of invention for the treatment of rheumatoid Chinese medicine, is by Caulis Sinomenii, Caulis Piperis Kadsurae, Caulis Lonicerae, Caulis Spatholobi, Flos Carthami, Lumbricus, Radix Gentianae Macrophyllae, Radix Laporteae Macrostachyae, Radix Craibiodendri, Radix Cynanchi Paniculati, Herba Pileae Scriptae, Caulis Fissistigmatis, Herba Aristolochiae Mollissimae, be ground into powder face respectively, mix homogeneously, be distributed into wafer or make pill; Its compatibility is: Caulis Sinomenii 25-50g, Caulis Piperis Kadsurae 25-50g, Caulis Lonicerae 25-50g, Caulis Spatholobi 25-50g, Flos Carthami 15-30g, Lumbricus 15-30g, Radix Gentianae Macrophyllae 15-30g, Radix Laporteae Macrostachyae 15-30g, Radix Craibiodendri 15-30g, Radix Cynanchi Paniculati 25-50g, Herba Pileae Scriptae 25-50g, Caulis Fissistigmatis 15-30g, Herba Aristolochiae Mollissimae 25-50g.The present invention has nourishing YIN and clearing away heat dampness removing, and blood blood stasis dispelling, dispelling wind and removing obstruction in the collateral, dispelling cold by warming the meridian pain relieving, strengthen immunologic function, reconcile endocrine, promote the effects such as equilibrium between yin and yang, cure mainly rheumatoid and rheumatic arthritis, its deficiency is: take this medicine DeGrain, and effect is little.
CN1559496 discloses a kind of patent of invention for the treatment of the Chinese medicine dredging collateral preparation of rheumatoid arthritis, crude drug primarily of following weight portion is made: the Radix Aucklandiae, Semen Persicae, Cortex Moutan, Radix Paeoniae Rubra, Rhizoma Corydalis, the Rhizoma Pinelliae, Poria, Radix Et Rhizoma Rhei, Radix Bupleuri, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Anemarrhenae, Radix Codonopsis, Radix Rehmanniae Preparata, Radix Saposhnikoviae, Herba Lycopodii, Herba speranskiae tuberculatae, Olibanum, Myrrha, Radix Glycyrrhizae, the present invention is in the process taken, any internal organs are not all damaged, more old complaint more can not add again the consequence of new disease; Have abundant raw material, cheap, technique is simple, and simple for production, have no side effect, its deficiency is that curative effect is undesirable, makes rheumatism atrophic arthritis patient obstinate, can not eradicate disease completely.
Up to the present, a kind of Chinese medicine curing rheumatism, rheumatoid arthritis is not also had.
Summary of the invention
The object of the invention is to solve above-mentioned the deficiencies in the prior art, provide a kind of evident in efficacy, safe, inexpensive, eliminating toxic substances to remove stasis purging FU-organs to be Therapeutic Principle, coordinate the product of other clearing away heat and eliminating dampness, eliminating evil and do not hinder the compound Chinese medicinal preparation of positive treatment advanced pancreatic cancer.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of compound Chinese medicinal preparation for the treatment of advanced pancreatic cancer, it is characterized in that crude drug is be made up of following component by weight ratio: Herba Hedyotidis Diffusae 30g, Scorpio 9g, Gekko Swinhonis 5g, Rhizoma Amorphophalli 5g, Radix Sophorae Tonkinensis 15g, Radix Et Rhizoma Rhei 6g, Herb Gynostemmae Pentaphylli 15g, Fructus Amomi Rotundus 10g, by above-mentioned Herba Hedyotidis Diffusae, Scorpio, Gekko Swinhonis, Rhizoma Amorphophalli, Radix Sophorae Tonkinensis, Radix Et Rhizoma Rhei, Herb Gynostemmae Pentaphylli, Fructus Amomi Rotundus to be got it filled mix homogeneously by proportioning, mixed above-mentioned Chinese crude drug is joined many kinetic energy extractor, soak half an hour, decoct 1.5 hours, and then be condensed into the mastic of proportion 1.3, mastic, dextrin, Icing Sugar according to the ratio of 1:1:3 pour in blender stir after, the uniform granule of 10-14 order is made again in crowded grain machine, dry in 60 ° of C---80 ° of C environment, 5g/ bag, day three times.
Instructions of taking: every day, oral drug dose was 5 grams, every bu early, middle and late three times oral, each 1 bag.
The present invention avoids: low leukocyte counts, hepatic and kidney function obstacle person, digestive tract ulcer person are cautious use of, and anemia of pregnant woman avoids.
Prescription solution in the present invention is:
Herba Hedyotidis Diffusae: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, promoting urination to remove dampness.Can swell and ache in acute appendicitis, lung abscess, furuncle, venom.Also for various tumor, digestive tract and lymph tumor is especially used for.Alone or with the curing oncoma medicine compatibilities such as Radix Sophorae Tonkinensis, Herba Scutellariae Barbatae, Rhizoma Dioscoreae Bulbiferae.Modern pharmacological research, Herba Hedyotidis Diffusae is containing hentriacontane, stigmasterol, sitosterol, maloic acid, P-coumaric acid, Herba Hedyotidis Diffusae element (may be Coumarins) flavonoid glycoside etc.Can the immunocompetence of remarkable enhancing body, as stimulated reticuloendothelial cell hyperplasia, make to engulf active, enhancing antibody is formed, and during lymph node, spleen, liver etc. are organized, argentophile substance be densification change.There is antitumor action.Again can adrenal cortex reinforcing function, and have analgesia, calmness, syngignoscism.
Scorpio: acrid in the mouth, poisonous, there is dispersing pathogen accumulation, the effect of removing obstruction in the collateral to relieve pain.Scorpio pharmacological action: scorpion extraction liquid has suppression animal thrombosis to be formed and anticoagulation; Scorpion body and scorpion tail preparation all have obvious analgesic activity to animal body pain or Encelialgia; Scorpion tail analgesic activity is than scorpion stiffness of the body about 5 times; Scorpio water, alcohol extract have inhibitory action to human hepatocellular and colon cancer cell respectively.
Gekko Swinhonis: salty, cold, slightly poisonous, has and dispels the wind, active, effect of eliminating stagnation, is applicable to tumor, tuberculosis, osteomyelitis, malignant boil, paralysis due to windstroke, the treatment of the diseases such as severe and migratory arthralgia pain, the mass-dissipating efficacy of Gekko Swinhonis is applicable to the treatment of tumor, and mass-dissipating efficacy is passed through in Gekko Swinhonis, there is good dissipation role for vivotoxin alluvial, promote that body circulation is unobstructed, prevent alluvial from forming lump or tumor body, and have good dissipation role for the lump formed and tumor body, contribute to reduction of patient lump pressure symptom.
Rhizoma Amorphophalli: property is pungent, temperature, poisonous, there is loose amassing of reducing phlegm, effect of clots absorbing detumescence.
Radix Sophorae Tonkinensis: bitter, cold, relieves inflammation or internal heat, removing toxic substances, detumescence, effect of pain relieving.Modern pharmacological research shows that Radix Sophorae Tonkinensis has remarkable result to malignant tumor. side effect is little, safety, and the person that do not make leukopenia.
Radix Et Rhizoma Rhei: heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
Herb Gynostemmae Pentaphylli: heat-clearing and toxic substances removing, can suppress to kill cancerous cell.Strengthen the activity of blood of human body medium-sized lymphocyte, strengthen the immunologic function of human body.
Fructus Amomi Rotundus: pungent, large temperature, nontoxic.Removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting.Circulation of qi promoting, warming the stomach, helps digestion, alleviating distention in middle-JIAO.
Theoretical unique in the present invention: the common Shi Re Bing Pian of most Pancreas cancer patients, blood stasis, the stagnation of QI clinically, three hands over the symptom of resistance, and it is the pathology key of cancer of pancreas that the malicious stasis of blood is tied mutually, and core pathogenesis is " domination of pathogen ".Therefore eliminating toxic substances to remove stasis purging FU-organs is principle for the treatment of.Compatibility of drugs is unique: multiple insect medicine in eliminating toxic substances to remove stasis purging FU-organs granule use, and coordinate the product that heat-clearing and toxic substances removing blood stasis dispelling is captured, treating the poisonous disease with poisonous drugs, removing toxic substances, blood stasis dispelling, purging FU-organs are laid equal stress on.Drug effect is direct: prescription is based on insect medicine, and property is apt to away alter, and easily reaches focus.Our with Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, promoting urination to remove dampness is monarch drug; Ministerial drug: Scorpio, Gekko Swinhonis dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain, Rhizoma Amorphophalli reduces phlegm loose long-pending, and clots absorbing is subsided a swelling, Radix Sophorae Tonkinensis, Herb Gynostemmae Pentaphylli relieve inflammation or internal heat, removing toxic substances and promoting subsidence of swelling, pain relieving.Radix Et Rhizoma Rhei heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation; Adjuvant: Fructus Amomi Rotundus removing dampness circulation of qi promoting, warming middle-JIAO.
Detailed description of the invention:
Treat a compound Chinese medicinal preparation for advanced pancreatic cancer, it is characterized in that crude drug is be made up of following component by weight ratio: Herba Hedyotidis Diffusae 30g, Scorpio 9g, Gekko Swinhonis 5g, Rhizoma Amorphophalli 5g, Radix Sophorae Tonkinensis 15g, Radix Et Rhizoma Rhei 6g, Herb Gynostemmae Pentaphylli 15g, Fructus Amomi Rotundus 10g.
Manufacture method of the present invention: Herba Hedyotidis Diffusae, Scorpio, Gekko Swinhonis, Rhizoma Amorphophalli, Radix Sophorae Tonkinensis, Radix Et Rhizoma Rhei, Herb Gynostemmae Pentaphylli, Fructus Amomi Rotundus.To get it filled mix homogeneously by proportioning; above-mentioned Chinese crude drug adds many kinetic energy extractor; soak half an hour; decoct 1.5 hours, and then be condensed into the mastic of proportion 1.3, mastic, dextrin, Icing Sugar according to the ratio of 1:1:3 pour in blender stir after; the uniform granule of 10-14 order is made again in crowded grain machine; dry in 60 ° of C---80 ° of C environment, 5g/ bag, day three times.
Embodiment 1: get Herba Hedyotidis Diffusae 30g, Scorpio 9g, Gekko Swinhonis 5g, Rhizoma Amorphophalli 5g, Radix Sophorae Tonkinensis 15g, Radix Et Rhizoma Rhei 6g, Herb Gynostemmae Pentaphylli 15g, Fructus Amomi Rotundus 10g; above-mentioned preparation totally 30 pairs of Chinese medicine with together with; join many kinetic energy extractor; soak half an hour; decoct 1.5 hours; and then be condensed into the mastic of proportion 1.3; mastic, dextrin, Icing Sugar according to the ratio of 1:1:3 pour in blender stir after; the uniform granule of 10-14 order is made again in crowded grain machine; dry in 60 ° of C---80 ° of C environment; 5g/ bag, day three times.
Embodiment 2: get Herba Hedyotidis Diffusae 30g, Scorpio 9g, Gekko Swinhonis 5g, Rhizoma Amorphophalli 5g, Radix Sophorae Tonkinensis 15g, Radix Et Rhizoma Rhei 6g, Herb Gynostemmae Pentaphylli 15g, Fructus Amomi Rotundus 10g; above-mentioned preparation totally 45 pairs of Chinese medicine with together with; join many kinetic energy extractor; soak half an hour; decoct 1.5 hours; and then be condensed into the mastic of proportion 1.3; mastic, dextrin, Icing Sugar according to the ratio of 1:1:3 pour in blender stir after; the uniform granule of 10-14 order is made again in crowded grain machine; dry in 60 ° of C---80 ° of C environment; 5g/ bag, day three times.
Embodiment 3: get Herba Hedyotidis Diffusae 30g, Scorpio 9g, Gekko Swinhonis 5g, Rhizoma Amorphophalli 5g, Radix Sophorae Tonkinensis 15g, Radix Et Rhizoma Rhei 6g, Herb Gynostemmae Pentaphylli 15g, Fructus Amomi Rotundus 10g; above-mentioned preparation totally 15 pairs of Chinese medicine with together with; join many kinetic energy extractor; soak half an hour; decoct 1.5 hours; and then be condensed into the mastic of proportion 1.3; mastic, dextrin, Icing Sugar according to the ratio of 1:1:3 pour in blender stir after; the uniform granule of 10-14 order is made again in crowded grain machine; dry in 60 ° of C---80 ° of C environment; 5g/ bag, day three times.
The clinical efficacy for the treatment of advanced pancreatic cancer is summed up:
One, physical data
Through 50 routine clinical treatments, wherein simple Chinese patent drugs for treatment 25 example, combined chemotherapy 25 example.
Two, diagnostic criteria
(1) pathological examination after operation (comprise and can excise the tumor maybe can not excising row biopsy) finds cancerous cell.(2) cancerous cell is found in the cytolgical examination of B ultrasonic guided fine needle aspiration.(3) B ultrasonic, CT, MRI, endoscopic retrograde cholangiopancreatography (ERCP) (ERCP), ultrasonic endoscope (EUS), percutaneous transhepatic puncture cholangiography (PTC) etc. confirm that pancreas has occupying lesion.(4) human pancreas cancer related antigen (span-1), CA19-9 (CA19-9), CA50 (CA-50); Gene test, as ras, C-erbB-2, C-myc are positive.Meet above (1) or (2) article can make a definite diagnosis; And (3) although article have important value, the benign lesion in pancreas portion must be got rid of, in conjunction with (4) article, also can be used as clinical diagnosis.
syndrome Differentiation of Traditional Chinese Medicine standard: by " new Chinese medicine treatment cancer of pancreas clinical guidance principle "
Three, instructions of taking
Take compound preparation of the present invention, early, middle and late three times of every bu, each 1 bag one month is a course for the treatment of.
Four, efficacy assessment standard:
Tcm syndrome efficacy assessment standard: " new Chinese medicine guideline of clinical investigations " [3] with reference to Zheng Xiao cornel chief editor draft TCM symptom score standard (see annex 2), Estimating curative effect application integration method, the weight of the degree that has that it's too late of symptom is score basis, and the change before and after comparison therapy.(1) effective: clinical TCM syndrome integration declines >=70%; (2) effective: clinical TCM syndrome integration declines >=30%; (3) invalid: clinical TCM syndrome integration decline < 30% or rising.Effective percentage=[effective (n)+effectively (n)/sum (n)] × 100%.
Quality of life (1) body weight change: 1. increase: the comparatively rear body weight increase >=lkg for the treatment of before treatment; 2. stablize: increase after treatment or reduce less than lkg; 3. decline: comparatively lose weight after treatment before treatment >=lkg.(2) KPS scoring: with reference to Karnofsky point system (see annex 3) 1. raises: comparatively treatment before treatment after KPS mark increase >=10 points; 2. stablize: after treatment, KPS scoring increases or reduce less than 10 points; 3. decline: comparatively before treatment, after treatment, KPS scoring reduces >=10 points.
Toxicity assessment: by WHO standard.Safety observation index: before and after medication, each work once, each Testing index treatment group at least 1/3 case: (1) general health check-up project: temperature pulse respiration.(2) blood, urine, stool routine examination inspection, before and after treatment, each work once.(3) liver function AST, ALT; Renal function BUN, CR and blood glucose; Cardiac function CPK, LDH, EKG; Coagulation function and platelet; Before and after treatment, each record once.
Other toxicity: be divided into 0-4 level.Performance: the symptoms such as blood system, digestive system, cardiovascular system, urinary system, nervous system, allergy, skin.Classification: 0 grade: avirulence Symptoms; L level: mild toxicity Symptoms; 2 grades: moderate signs of toxicity shows; 3 grades: serious toxicity Symptoms; 4 grades: threat to life signs of toxicity shows.
Five, therapeutic effect
A month course for the treatment of, a course for the treatment of of the lighter, severe one can take a turn for the better two to three courses for the treatment of.
In 50 routine patients, take a turn for the better 43 examples, invalid 7 examples, effective percentage 86%.
The present invention avoids: low leukocyte counts, hepatic and kidney function obstacle person, digestive tract ulcer person are cautious use of, and anemia of pregnant woman avoids.
Six, model case
1, patient Zhang, female, 58 years old, people from Fushan District, Yantai, find advanced pancreatic cancer March, because abdominal distention, jaundice are examined more than January, take 3 courses for the treatment of of the present invention, abdominal distention symptom disappears completely, jaundice changes latent jaundice into by clinical jaundice, and patient is conscious of significant discomfort, follows up a case by regular visits to stable disease in March.
2, patient Liu, man, 72 years old, people from Zhifu District, Yantai, main suit: find cancer of pancreas examine January, Multiple Hospitalization chemotherapy, therapeutic scheme take this product walk abreast single medicine pool luxuriant and rich with fragrance scheme chemotherapy, after 4 cycle chemotherapy, chemotherapeutic period patient without obvious chemotherapy toxic side effect I, without special toxicity---late-onset diarrhea, patients ' life quality obviously improves, Ka Shi scoring rises to 90 points by 70 points, and tumor markers obviously declines.End of chemotherapy continues to take two courses for the treatment of of the present invention, periodic review, and 1 year so far stable disease, gets nowhere.
3, patient Lee so-and-so, man, 56 years old, people from urban district, Weihai, after main suit finds cancer of pancreas Gamma knife treatment in February, because of abdominal distention, poor appetite, became thin and examines, and takes 3 courses for the treatment of of the present invention, again from having taken 2 courses for the treatment of after symptom disappears completely, regularly had a medical check-up, so far stable disease.
Prescription solution in the present invention is:
Herba Hedyotidis Diffusae: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, promoting urination to remove dampness.Can swell and ache in acute appendicitis, lung abscess, furuncle, venom.Also for various tumor, digestive tract and lymph tumor is especially used for.Alone or with the curing oncoma medicine compatibilities such as Radix Sophorae Tonkinensis, Herba Scutellariae Barbatae, Rhizoma Dioscoreae Bulbiferae.Modern pharmacological research, Herba Hedyotidis Diffusae is containing hentriacontane, stigmasterol, sitosterol, maloic acid, P-coumaric acid, Herba Hedyotidis Diffusae element (may be Coumarins) flavonoid glycoside etc.Can the immunocompetence of remarkable enhancing body, as stimulated reticuloendothelial cell hyperplasia, make to engulf active, enhancing antibody is formed, and during lymph node, spleen, liver etc. are organized, argentophile substance be densification change.There is antitumor action.Again can adrenal cortex reinforcing function, and have analgesia, calmness, syngignoscism.Scorpio: acrid in the mouth, poisonous, there is dispersing pathogen accumulation, the effect of removing obstruction in the collateral to relieve pain.Scorpio pharmacological action: scorpion extraction liquid has suppression animal thrombosis to be formed and anticoagulation; Scorpion body and scorpion tail preparation all have obvious analgesic activity to animal body pain or Encelialgia; Scorpion tail analgesic activity is than scorpion stiffness of the body about 5 times; Scorpio water, alcohol extract have inhibitory action to human hepatocellular and colon cancer cell respectively.Gekko Swinhonis: salty, cold, slightly poisonous, has and dispels the wind, active, and effect of eliminating stagnation, is applicable to tumor, tuberculosis, osteomyelitis, malignant boil, paralysis due to windstroke, the treatment of the diseases such as severe and migratory arthralgia pain.The mass-dissipating efficacy of Gekko Swinhonis is applicable to the treatment of tumor.Mass-dissipating efficacy is passed through in Gekko Swinhonis, there is good dissipation role for vivotoxin alluvial, promote that body circulation is unobstructed, prevent alluvial from forming lump or tumor body, and have good dissipation role for the lump formed and tumor body, contribute to reduction of patient lump pressure symptom.Rhizoma Amorphophalli: property is pungent, temperature, poisonous, there is loose amassing of reducing phlegm, effect of clots absorbing detumescence.Radix Sophorae Tonkinensis: bitter, cold, relieves inflammation or internal heat, removing toxic substances, detumescence, effect of pain relieving.Modern pharmacological research shows that Radix Sophorae Tonkinensis has remarkable result to malignant tumor. side effect is little, safety, and the person that do not make leukopenia.Radix Et Rhizoma Rhei: heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Herb Gynostemmae Pentaphylli: heat-clearing and toxic substances removing, can suppress to kill cancerous cell.Strengthen the activity of blood of human body medium-sized lymphocyte, strengthen the immunologic function of human body.Fructus Amomi Rotundus: pungent, large temperature, nontoxic.Removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting.Circulation of qi promoting, warming the stomach, helps digestion, alleviating distention in middle-JIAO.
Theoretical unique in the present invention: the common Shi Re Bing Pian of most Pancreas cancer patients, blood stasis, the stagnation of QI clinically, three hands over the symptom of resistance, and it is the pathology key of cancer of pancreas that the malicious stasis of blood is tied mutually, and core pathogenesis is " domination of pathogen ".Therefore eliminating toxic substances to remove stasis purging FU-organs is principle for the treatment of.Compatibility of drugs is unique: multiple insect medicine in eliminating toxic substances to remove stasis purging FU-organs granule use, and coordinate the product that heat-clearing and toxic substances removing blood stasis dispelling is captured, treating the poisonous disease with poisonous drugs, removing toxic substances, blood stasis dispelling, purging FU-organs are laid equal stress on.Drug effect is direct: prescription is based on insect medicine, and property is apt to away alter, and easily reaches focus.Our with Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, promoting urination to remove dampness is monarch drug; Ministerial drug: Scorpio, Gekko Swinhonis dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain, Rhizoma Amorphophalli reduces phlegm loose long-pending, and clots absorbing is subsided a swelling, Radix Sophorae Tonkinensis, Herb Gynostemmae Pentaphylli relieve inflammation or internal heat, removing toxic substances and promoting subsidence of swelling, pain relieving.Radix Et Rhizoma Rhei heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation; Adjuvant: Fructus Amomi Rotundus removing dampness circulation of qi promoting, warming middle-JIAO.Full side plays the effect of eliminating toxic substances to remove stasis purging FU-organs jointly, and a large amount of modern pharmacological researches confirms that our contained drug is by different mechanisms, the anticancer cancer suppressing action of performance in various degree.Treatment damp heat and phlegm retention advanced pancreatic cancer, can mitigation symptoms, and treatment of making the life better, improves immunity of organisms, prolongation life cycle.Combined chemotherapy can attenuation synergistic, improves chemotherapeutic efficacy.And there is the advantages such as evident in efficacy, safe, inexpensive, easy to use.
Claims (1)
1. treat the compound Chinese medicinal preparation of advanced pancreatic cancer for one kind, it is characterized in that crude drug is be made up of following component by weight ratio: Herba Hedyotidis Diffusae 30g, Scorpio 9g, Gekko Swinhonis 5g, Rhizoma Amorphophalli 5g, Radix Sophorae Tonkinensis 15g, Radix Et Rhizoma Rhei 6g, Herb Gynostemmae Pentaphylli 15g, Fructus Amomi Rotundus 10g, by above-mentioned Herba Hedyotidis Diffusae, Scorpio, Gekko Swinhonis, Rhizoma Amorphophalli, Radix Sophorae Tonkinensis, Radix Et Rhizoma Rhei, Herb Gynostemmae Pentaphylli, Fructus Amomi Rotundus to be got it filled mix homogeneously by proportioning, mixed above-mentioned Chinese crude drug is joined many kinetic energy extractor, soak half an hour, decoct 1.5 hours, and then be condensed into the mastic of proportion 1.3, mastic, dextrin, Icing Sugar according to the ratio of 1:1:3 pour in blender stir after, the uniform granule of 10-14 order is made again in crowded grain machine, dry in 60 ° of C---80 ° of C environment.
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| CN1356125A (en) * | 2001-10-11 | 2002-07-03 | 刘伟东 | Medicine for treating tumor |
| CN1391949A (en) * | 2002-08-01 | 2003-01-22 | 复旦大学附属肿瘤医院 | Chinese medicine compound preparation for curing pancreatic cancer |
| CN1518998A (en) * | 2003-01-24 | 2004-08-11 | 侯希彦 | Chinese material medica preparation for treating cancer |
| CN101670071A (en) * | 2009-09-25 | 2010-03-17 | 卢速江 | Traditional Chinese medicine preparation for treating cancer and preparation method thereof |
| CN102772745B (en) * | 2012-08-21 | 2013-12-04 | 卢速江 | Chinese medicinal preparation for treating cancer and preparation method thereof |
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