CN107998354A - Improve the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foam foot agent and preparation method thereof - Google Patents
Improve the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foam foot agent and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to field of traditional Chinese, and more particularly to improve the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foam foot agent and preparation method thereof；Medicinal raw material includes：The Chinese cassia tree of 45 55 parts by weight, the evodia rutaecarpa of 95 105 parts by weight, the ginger of 145 155 parts by weight, the onion of 45 55 parts by weight, the Chinese prickly ash of 75 85 parts by weight, the actinolite of 15 25 parts by weight；Preparation method includes preparing extract and fermentation；The preparation method can fully extract the active ingredient in medicinal raw material, to reduce the input of raw material；And the preparation method can improve absorption of the human body to medicine, and then the symptoms such as the pain in the back of user, skelasthenia can be alleviated.
Description
Technical field
The present invention relates to field of traditional Chinese, and more particularly to improve the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee foam foot agent and
Its preparation method.
Background technology
Applying for Chinese medicine pedicure has long history in China, bubble foot be by temperature and medicine, using skin it is imperial it is evil,
The multiple functions such as secretion, absorption, infiltration, excretion, sensation, act on local skin, muscle, joint, improve being metabolized, by force for three
Change its function, and by absorption of the skin to medicine, treated for the disease of part and whole body.It can reconcile whole body gas
Blood, adjusts viscera function, treats a variety of diseases.But in existing pedicure medicament, the utilization to medicinal raw material is insufficient, treatment
It is ineffective, absorption of the user to medicament active ingredient is limited, not only causes the waste of medicinal raw material, does not reach needs also
Health-care effect.
The content of the invention
It is an object of the invention to provide a kind of powerless Chinese medicine of kidney deficiency, pain in the back, leg knee that improves to foam foot agent, which can
Absorbability of the patient to effective ingredient is improved, and then improves drug effect, alleviates the symptoms such as pain in the back, the skelasthenia of user.
Another object of the present invention is to provide a kind of preparation for improving the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foaming foot agent
Method, the preparation method can fully extract the active ingredient in medicinal raw material, to reduce the input of raw material；And should
Preparation method can improve absorption of the human body to medicine, and then can alleviate the symptoms such as the pain in the back of user, skelasthenia.
The present invention is realized using following technical scheme.
The present invention proposes that a kind of powerless Chinese medicine of kidney deficiency, pain in the back, leg knee that improves foams foot agent, its medicinal raw material includes：45-55
The Chinese cassia tree of parts by weight, the evodia rutaecarpa of 95-105 parts by weight, the ginger of 145-155 parts by weight, onion, the 75-85 of 45-55 parts by weight
Chinese prickly ash, the actinolite of 15-25 parts by weight of parts by weight.
The present invention proposes that a kind of powerless Chinese medicine of kidney deficiency, pain in the back, leg knee that improves foams foot the preparation method of agent, including prepares medicine
Material raw material, prepare extract and fermentation.
Wherein, medicinal raw material includes the first medicinal raw material and the second medicinal raw material, and the first medicinal raw material includes：45-55 weights
Measure the Chinese cassia tree of part, the evodia rutaecarpa of 95-105 parts by weight, the ginger of 145-155 parts by weight, the Chinese prickly ash of 75-85 parts by weight, 15-25 weights
The actinolite of part is measured, the second medicinal raw material includes：The onion of 45-55 parts by weight；
Preparing extract includes：Onion is ground into onion slurry, adds water and onion to starch in the powder of the first medicinal raw material
Decoct, be cooled to decoct thing temperature be 25-30 DEG C after add Bifidobacterium and carry out just fermentation, just filtered after fermentation, obtain the
One extracting solution and first dregs of a decoction；First dregs of a decoction alcohol reflux of 30-50vol% is extracted, obtains the second extracting solution and second
The dregs of a decoction；
Fermentation includes：It is concentrated in vacuo after first extracting solution and the second extracting solution are mixed, it is 1.05- to obtain relative density
1.1 clear cream；Saccharomycete is added in clear cream, is subsequently placed under the conditions of temperature is 25-30 DEG C and ferments, then sterilization treatment, obtain
First fermentation liquid；Second dregs of a decoction are placed under the conditions of temperature is 30-35 DEG C and are fermented, decoction is added water and filters, obtain second
Ferment liquid；The fermentation liquid of mixing first and the second fermentation liquid.
The powerless Chinese medicine of the improvement kidney deficiency of the embodiment of the present invention, pain in the back, leg knee foams foot the beneficial effect of agent and preparation method thereof
Fruit is：The preparation method can fully extract the active ingredient in medicinal raw material, to reduce the input of raw material；And by
The preparation method prepare prescription agent can promote absorption of the human body to medicine, and then can alleviate the pain in the back of user, leg without
The symptoms such as power.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer, is the conventional production that can be obtained by commercially available purchase
Product.
Below the powerless Chinese medicine of the improvement kidney deficiency to the embodiment of the present invention, pain in the back, leg knee foam foot agent and preparation method thereof into
Row illustrates.
The medicinal raw material that the powerless Chinese medicine of the improvement kidney deficiency of the present invention, pain in the back, leg knee foams foot agent includes：45-55 parts by weight
Chinese cassia tree, the evodia rutaecarpa of 95-105 parts by weight, the ginger of 145-155 parts by weight, the onion of 45-55 parts by weight, 75-85 parts by weight
Chinese prickly ash, the actinolite of 15-25 parts by weight.
Preferably, above-mentioned medicinal raw material includes the Chinese cassia trees of 50 parts by weight, the evodia rutaecarpa of 100 parts by weight, 150 parts by weight
Ginger, the onion of 50 parts by weight, the Chinese prickly ash of 80 parts by weight, the actinolite of 20 parts by weight.It should be noted that the green onion in the present invention
Head is onion, and is untreated fresh onion.
Chinese cassia tree, evodia rutaecarpa, ginger, onion, Chinese prickly ash and actinolite are respectively provided with cold extermination, relieve pain, go edema, analgesic, qi-regulating etc.
Effect.The prescription agent prepared by above-mentioned medicinal raw material, can alleviate the symptoms such as pain in the back, the skelasthenia of user.
The preparation method that the powerless Chinese medicine of the improvement kidney deficiency, pain in the back, leg knee foams foot agent includes preparation medicinal raw material, preparation carries
Take thing and fermentation.
In detail, after preparing raw material according to the parts by weight of above-mentioned medicinal raw material, onion is ground into onion slurry, will be except
The powder of medicinal raw material outside onion adds water and above-mentioned onion to starch and decoct, after the temperature for being cooled to decoction thing is 25-30 DEG C
Add Bifidobacterium and carry out just fermentation, the first extracting solution and first dregs of a decoction just is obtained by filtration after fermentation, by the first dregs of a decoction 30-
The alcohol reflux extraction of 50vol%, obtains the second extracting solution and second dregs of a decoction.The concentration of Bifidobacterium can be with above-mentioned decoction thing
It is 1 × 104-105CFU/g；The fermentation temperature for decocting thing is 25-30 DEG C, and the fermentation time for decocting thing is 24-36h.
The particle diameter of above-mentioned medicinal raw material (removing actinolite) powder can be 300-500 mesh, and the particle diameter of Tremolite can be with
It is 800-1000 mesh, and can is that each medicinal powder directly bought is stocked up according to required parts by weight；Can also be
After being stocked up with the medicinal powder not being milled according to required parts by weight, milling processing is carried out before refluxing extraction.
The weight ratio of above-mentioned medicinal raw material and 30-50vol% ethanol is 1:5-10, the temperature of refluxing extraction can be 30-
50 DEG C, the time of extraction can be 2-3h.According to the method described above carry out refluxing extraction can improve in first dregs of a decoction it is effective into
The it is proposed amount divided.
The time that medicinal raw material adds water to cook can be 1-3h, and can also further be surpassed while decocting
Sonication, supersonic frequency can be 20-30KHz.The water added in medicinal raw material can be 3-5 times of medicinal raw material weight.
Foregoing fermentation includes：It is concentrated in vacuo, is obtained relatively close after first extracting solution and the second extracting solution are mixed
Spend for the clear cream of 1.05-1.1 (35 DEG C), saccharomycete added in clear cream, be subsequently placed in temperature to ferment under the conditions of 25-30 DEG C,
Sterilization treatment again, obtains the first fermentation liquid；Second dregs of a decoction are placed under the conditions of temperature is 30-35 DEG C and are fermented, add water decoction
And filter, obtain the second fermentation liquid；The fermentation liquid of mixing first and the second fermentation liquid.
It should be noted that above-mentioned vacuum drying can be -0.01MPa~-0.02MPa, temperature 40- in vacuum pressure
Carried out under the conditions of 50 DEG C；Above-mentioned sterilizing can with Technology of Ultra-high Pressure Sterilization of the prior art, cold sterilization, pasteurization,
Ultrahigh-temperature instant sterilization or microwave disinfection etc..
Further, the concentration of saccharomycete can be 1 × 10 in above-mentioned clear cream4-105CFU/g.Yeast is added in clear cream
Bacterium is fermented, and can improve the ability that obtained prescription agent is absorbed by the body, and then improve the effect for the treatment of.Above-mentioned clear cream hair
The time of ferment can be 24-48h.It should be noted that the Bifidobacterium and saccharomycete of addition can be with commercially available saccharomycete
According to the saccharomycete after the common various prior arts activation of microorganism or it is autonomous after purification, active ferment
Female bacterium.
The fermentation time of second dregs of a decoction can be 24-48h, and second dregs of a decoction are fermented a period of time at a higher temperature
Afterwards, decocting again further can extract the active ingredient in medicinal material, you can further to improve obtained medicine
The drug effect of prescription, improves therapeutic effect.When second dregs of a decoction after fermentation decoct, the water of addition is the 1-2 of the second dregs of a decoction weight
Times, the time of decoction can be 30-60min.
First fermentation liquid and second fermentation liquid mixing after, the liquid of mixing can be further made pulvis,
Granule, aqua or paste, such as：Pulvis is made in admixing medical solutions spray drying；Paste is made in admixing medical solutions concentration；Directly
Aqua is made in admixing medical solutions；Admixing medical solutions concentration postcooling is granulated granule etc. is made.
It should be noted that each parts by weight of above-mentioned medicinal raw material are identical, such as：Each parts by weight for 1kg,
1g etc..
The powerless Chinese medicine of improvement kidney deficiency, pain in the back, leg knee to the present invention foams foot agent and its preparation side with reference to embodiments
Method is described in further detail.
Embodiment 1
Prepare medicinal raw material, including：The Chinese cassia tree of 45 parts by weight, the evodia rutaecarpa of 105 parts by weight, the ginger of 145 parts by weight, 55
The onion of parts by weight, the Chinese prickly ash of 85 parts by weight, the actinolite of 25 parts by weight.
Onion is ground into onion slurry, adds water and above-mentioned onion to starch and decoct in the powder of the medicinal raw material in addition to onion
1h (100 DEG C), the temperature for being cooled to decoction thing for 25 DEG C of addition Bifidobacteriums just ferment, and the first extracting solution is obtained after filtering
With first dregs of a decoction, the concentration for decocting Bifidobacterium in thing is 1 × 104CFU/g, the fermentation temperature for decocting thing are 30 DEG C, decoct thing
Fermentation time be 24h, the water added in medicinal raw material is 3 times of medicinal raw material weight；With the ethanol of 30vol% to the first medicine
Slag reflux extraction；Wherein, the weight ratio of medicinal raw material and ethanol is 1:5, the temperature of refluxing extraction is 30 DEG C, time 3h；Return
The second extracting solution and second dregs of a decoction are obtained after stream extraction.
It is -0.01MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, under the conditions of temperature is 40 DEG C
It is concentrated in vacuo, obtains the clear cream that relative density is 1.05 (35 DEG C), add saccharomycete in obtained clear cream, be placed in 25 DEG C of conditions
Under, ferment 24h, then microwave disinfection, obtains the first fermentation liquid；The concentration of saccharomycete is 1 × 10 wherein in clear cream4CFU/g.Will
Second dregs of a decoction are placed under the conditions of temperature is 30 DEG C the 24h that ferments, then add the water of 1 times of amount of the second dregs of a decoction weight, decoct 30min, mistake
Filter, obtains the second fermentation liquid.
By first fermentation liquid and second fermentation liquid mix after, spray drying pulvis is made, you can obtain improve kidney deficiency,
The powerless Chinese medicine of pain in the back, leg knee foams foot agent.
Embodiment 2
Prepare medicinal raw material, including：The Chinese cassia tree of 55 parts by weight, the evodia rutaecarpa of 95 parts by weight, the ginger of 155 parts by weight, 45
The onion of parts by weight, the Chinese prickly ash of 75 parts by weight, the actinolite of 15 parts by weight.
Onion is ground into onion slurry, adds water and above-mentioned onion to starch and decoct in the powder of the medicinal raw material in addition to onion
3h (100 DEG C), the temperature for being cooled to decoction thing for 30 DEG C of addition Bifidobacteriums just ferment, and the first extracting solution is obtained after filtering
With first dregs of a decoction, the concentration for decocting Bifidobacterium in thing is 1 × 105CFU/g, the fermentation temperature for decocting thing are 25 DEG C, decoct thing
Fermentation time be 36h, the water added in medicinal raw material is 5 times of medicinal raw material weight；With the ethanol of 50vol% to the first medicine
Slag reflux extraction；Wherein, the weight ratio of medicinal raw material and ethanol is 1:10, the temperature of refluxing extraction is 50 DEG C, time 2h；Return
The second extracting solution and second dregs of a decoction are obtained after stream extraction.
It is -0.02MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, under the conditions of temperature is 50 DEG C
It is concentrated in vacuo, obtains the clear cream that relative density is 1.1 (35 DEG C), add saccharomycete in obtained clear cream, be placed in 30 DEG C of conditions
Under, ferment 48h, then microwave disinfection, obtains the first fermentation liquid；The concentration of saccharomycete is 1 × 10 wherein in clear cream5CFU/g.Will
Second dregs of a decoction are placed under the conditions of temperature is 35 DEG C the 48h that ferments, then add the water of 2 times of amounts of the second dregs of a decoction weight, decoct 60min, mistake
Filter, obtains the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, paste is made in concentration, you can obtains improving kidney deficiency, waist
Bitterly, the powerless Chinese medicine of leg knee foams foot agent.
Embodiment 3
Prepare medicinal raw material, including：The Chinese cassia tree (300 mesh) of 50 parts by weight, the evodia rutaecarpa (300 mesh) of 100 parts by weight, 150
Ginger (500 mesh), the onion of 50 parts by weight, Chinese prickly ash (400 mesh), the actinolite of 20 parts by weight of 80 parts by weight of parts by weight
(1000 mesh).
Onion is ground into onion slurry, adds water and above-mentioned onion to starch and decoct in the powder of the medicinal raw material in addition to onion
2h (97 DEG C), the temperature for being cooled to decoction thing for 27 DEG C of addition Bifidobacteriums just ferment, and the first extracting solution is obtained after filtering
With first dregs of a decoction, the concentration for decocting Bifidobacterium in thing is 5 × 104CFU/g, the fermentation temperature for decocting thing are 27 DEG C, decoct thing
Fermentation time be 30h, the water added in medicinal raw material is 4 times of medicinal raw material weight；With the ethanol of 40vol% to the first medicine
Slag carries out reflux extraction；Wherein, the weight ratio of medicinal raw material and ethanol is 1:7, the temperature of refluxing extraction is 40 DEG C, and the time is
2.5h；The second extracting solution and second dregs of a decoction are obtained after refluxing extraction.
It is -0.01MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, under the conditions of temperature is 45 DEG C
It is concentrated in vacuo, obtains the clear cream that relative density is 1.06 (35 DEG C), add saccharomycete in obtained clear cream, be placed in 27 DEG C of conditions
Under, ferment 36h, then microwave disinfection, obtains the first fermentation liquid；The concentration of saccharomycete is 8 × 10 wherein in clear cream4CFU/g.Will
Second dregs of a decoction are placed under the conditions of temperature is 31 DEG C the 36h that ferments, then add the water of 1.5 times of amounts of the second dregs of a decoction weight, decoct 40min,
Filtering, obtains the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, aqua is made, you can obtain improving kidney deficiency, pain in the back, leg
The powerless Chinese medicine of knee foams foot agent.
Embodiment 4
Prepare medicinal raw material, including：The Chinese cassia tree of 53 parts by weight, the evodia rutaecarpa of 102 parts by weight, the ginger of 148 parts by weight, 52
The onion of parts by weight, the Chinese prickly ash of 78 parts by weight, the actinolite (1000 mesh) of 18 parts by weight.
Onion is ground into onion slurry, adds water and above-mentioned onion to starch and decoct in the powder of the medicinal raw material in addition to onion
1.5h (100 DEG C), the temperature for being cooled to decoction thing for 27 DEG C of addition Bifidobacteriums just ferment, and the first extraction is obtained after filtering
Liquid and first dregs of a decoction, the concentration for decocting Bifidobacterium in thing is 3 × 104CFU/g, the fermentation temperature for decocting thing are 26 DEG C, are decocted
The fermentation time of thing is 32h, and the water added in medicinal raw material is 3.5 times of medicinal raw material weight, and medicinal raw material is in decoction
It is carried out at the same time supersound process, supersonic frequency 20KHz；Reflux extraction is carried out to first dregs of a decoction with the ethanol of 45vol%；Wherein,
The weight ratio of medicinal raw material and ethanol is 1:6, the temperature of refluxing extraction is 45 DEG C, time 2h；Second is obtained after refluxing extraction
Extracting solution and second dregs of a decoction.
It is -0.015MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, and temperature is 45 DEG C of conditions
Lower vacuum concentration, obtains the clear cream that relative density is 1.1 (35 DEG C), adds saccharomycete in obtained clear cream, be placed in 28 DEG C of bars
Under part, ferment 30h, then microwave disinfection, obtains the first fermentation liquid；The concentration of saccharomycete is 5 × 10 wherein in clear cream4CFU/g。
Second dregs of a decoction are placed under the conditions of temperature is 33 DEG C the 30h that ferments, then add the water of 1.2 times of amounts of the second dregs of a decoction weight, are decocted
35min, filtering, obtains the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, granule is made in concentration, cooling granulation, you can is changed
The powerless Chinese medicine of kind kidney deficiency, pain in the back, leg knee foams foot agent.
Embodiment 5
Prepare medicinal raw material, including：The Chinese cassia tree of 48 parts by weight, the evodia rutaecarpa of 98 parts by weight, the ginger of 153 parts by weight, 48
The onion of parts by weight, the Chinese prickly ash of 82 parts by weight, the actinolite (800 mesh) of 22 parts by weight.
Onion is ground into onion slurry, adds water and above-mentioned onion to starch and decoct in the powder of the medicinal raw material in addition to onion
2.5h (99 DEG C), the temperature for being cooled to decoction thing for 28 DEG C of addition Bifidobacteriums just ferment, and the first extraction is obtained after filtering
Liquid and first dregs of a decoction, the concentration for decocting Bifidobacterium in thing is 9 × 104CFU/g, the fermentation temperature for decocting thing are 27 DEG C, are decocted
The fermentation time of thing is 33h, and the water added in medicinal raw material is 4.5 times of medicinal raw material weight, and medicinal raw material is in decoction
It is carried out at the same time supersound process, supersonic frequency 30KHz；Reflux extraction is carried out to first dregs of a decoction with the ethanol of 48vol%；Wherein,
The weight ratio of medicinal raw material and ethanol is 1:7, the temperature of refluxing extraction is 42 DEG C, time 2.5h；Is obtained after refluxing extraction
Two extracting solutions and second dregs of a decoction.
It is -0.02MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, under the conditions of temperature is 48 DEG C
It is concentrated in vacuo, obtains the clear cream that relative density is 1.05 (35 DEG C), add saccharomycete in obtained clear cream, be placed in 27 DEG C of conditions
Under, ferment 40h, then microwave disinfection, obtains the first fermentation liquid；The concentration of saccharomycete is 7 × 10 wherein in clear cream4CFU/g.Will
Second dregs of a decoction are placed under the conditions of temperature is 32 DEG C the 40h that ferments, then add the water of 1.6 times of amounts of the second dregs of a decoction weight, decoct 48min,
Filtering, obtains the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, granule is made in concentration, cooling granulation, you can is changed
The powerless Chinese medicine of kind kidney deficiency, pain in the back, leg knee foams foot agent.
Embodiment 6
Prepare medicinal raw material, including：The Chinese cassia tree of 48 parts by weight, the evodia rutaecarpa of 98 parts by weight, the ginger of 153 parts by weight, 48
The onion of parts by weight, the Chinese prickly ash of 82 parts by weight, the actinolite of 22 parts by weight.
Onion is ground into onion slurry, adds water and above-mentioned onion to starch and decoct in the powder of the medicinal raw material in addition to onion
2h (97 DEG C), the temperature for being cooled to decoction thing for 30 DEG C of addition Bifidobacteriums just ferment, and the first extracting solution is obtained after filtering
With first dregs of a decoction, the concentration for decocting Bifidobacterium in thing is 2 × 104CFU/g, the fermentation temperature for decocting thing are 29 DEG C, decoct thing
Fermentation time be 29h, the water added in medicinal raw material is 3.2 times of medicinal raw material weight, and medicinal raw material is in the same of decoction
Shi Jinhang is ultrasonically treated, supersonic frequency 25KHz；Reflux extraction is carried out to first dregs of a decoction with the ethanol of 37vol%；Wherein, medicine
The weight ratio of material raw material and ethanol is 1:9, the temperature of refluxing extraction is 36 DEG C, time 2h；Second is obtained after refluxing extraction to carry
Take liquid and second dregs of a decoction.
It is -0.01MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, under the conditions of temperature is 45 DEG C
It is concentrated in vacuo, obtains the clear cream that relative density is 1.05 (35 DEG C), add saccharomycete in obtained clear cream, be placed in 26 DEG C of conditions
Under, ferment 42h, then ultrahigh-temperature instant sterilization, obtains the first fermentation liquid；Wherein in clear cream the concentration of saccharomycete for 3 ×
104CFU/g.Second dregs of a decoction are placed under the conditions of temperature is 32 DEG C the 42h that ferments, then add the water of 1.8 times of amounts of the second dregs of a decoction weight,
55min is decocted, filtering, obtains the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, granule is made in concentration, cooling granulation, you can is changed
The powerless Chinese medicine of kind kidney deficiency, pain in the back, leg knee foams foot agent.
Comparative example 1
The preparation method of comparative example 1 difference similar with the preparation method of embodiment 3 is, only medication in comparative example 1
Material raw material is decocted and is flowed back extraction, does not carry out related fermentation procedure, and with decocting and the extracting solution of reflux extraction is prepared into
Pulvis, weight, species and the condition of reflux extraction of medicinal raw material etc. refer to embodiment 3.
Comparative example 2
The preparation method and embodiment 3 of comparative example 2 are similar, and difference is, does not add in the medicinal raw material in comparative example 2
Add actinolite, remaining method and step is with reference to embodiment 3.
Comparative example 3
The preparation method and embodiment 3 of comparative example 3 are similar, and difference is, does not add in the medicinal raw material in comparative example 3
Add onion, remaining method and step is with reference to embodiment 3.
Comparative example 4
The preparation method and embodiment 3 of comparative example 4 are similar, and difference is, does not add in the medicinal raw material in comparative example 4
Add actinolite and onion, remaining method and step is with reference to embodiment 3.
Obtained prescription agent in embodiment 1-6 and comparative example 1-4 is used for experimental investigation, chooses age bracket at 30-35 Sui
100, the 40-45 Sui female patient 100 of female patient of male patient 100 and 30-35 Sui of male patient 100,40-45 Sui
Example, and the course of disease is 50-60d, performance symptom is waist is ached, leg knee is powerless etc.；It is randomly assigned 10 test groups again, every group
30-35 Sui 10,40-45 Sui female patient 10 of female patient of male patient 10,30-35 Sui of male patient 10,40-45 Sui
Example.
It you can well imagine the prescription agent for embodiment 1-6 and comparative example 1-4 per component, every group of every night is with the prescriptions of 30g each groups
1L bubble foot 30min are added in agent, and 7d is as a treatment course, after 2 courses for the treatment of, whether to investigate the corresponding illness of each respondent
Alleviate, criterion is as follows：
Recovery from illness：Waist, which aches to feel, to disappear, and leg knee is strong；It is effective：Waist is accidental to ache, and leg knee is accidental aching and limp；It is invalid：Waist
Ache, leg knee it is powerless.It the results are shown in Table 1.
The effect of 1 each group prescription agent of table be'ss to respondent result (number)
According to the comparing result of comparative example 1 and embodiment 1-5, carried out in preparation method of the invention first extraction
The fermentation of liquid and the second extracting solution and the fermentation of the dregs of a decoction etc., can provide out drug effect higher, the prescription agent for promoting sufferer to absorb for oneself,
Promote giving full play to for medicinal raw material drug effect.
According to the comparing result of comparative example 2-4 and embodiment 1-6, the formula in preparation method of the invention can have
Improvement waist in effect ground is ached, the symptom that leg knee is powerless, after adding actinolite and onion in being particularly formulated, can significantly be played
And improve prescription agent therapeutic effect.
In conclusion the powerless Chinese medicine of the improvement kidney deficiency of the embodiment of the present invention, pain in the back, leg knee foams foot agent and preparation method thereof
Beneficial effect be：The preparation method can fully extract the active ingredient in medicinal raw material, to reduce raw material
Input；And the prescription agent prepared by the preparation method can promote absorption of the human body to medicine, and then it can alleviate user's
The symptoms such as pain in the back, skelasthenia.
Embodiments described above is part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of powerless Chinese medicine of kidney deficiency, pain in the back, leg knee that improves foams foot agent, it is characterised in that its medicinal raw material includes：45-55
The Chinese cassia tree of parts by weight, the evodia rutaecarpa of 95-105 parts by weight, the ginger of 145-155 parts by weight, onion, the 75-85 of 45-55 parts by weight
Chinese prickly ash, the actinolite of 15-25 parts by weight of parts by weight.
2. kidney deficiency, pain in the back, the leg knee powerless Chinese medicine according to claim 1 that improves foams foot agent, it is characterised in that the medicine
Material raw material includes：The Chinese cassia tree of 50 parts by weight, the evodia rutaecarpa of 100 parts by weight, the ginger of 150 parts by weight, 50 weights
Measure the onion of part, the Chinese prickly ash of 80 parts by weight, the actinolite of 20 parts by weight.
3. a kind of preparation method for improving the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foaming foot agent, it is characterised in that including preparing medicine
Material raw material, prepare extract and fermentation, wherein,
The medicinal raw material includes the first medicinal raw material and the second medicinal raw material, and first medicinal raw material includes：45-55 weight
The Chinese cassia tree of part, the evodia rutaecarpa of 95-105 parts by weight, the ginger of 145-155 parts by weight, the Chinese prickly ash of 75-85 parts by weight, 15-25 weight
The actinolite of part, second medicinal raw material include：The onion of 45-55 parts by weight；
The extract for preparing includes：By the onion be ground into onion slurry, by the powder of first medicinal raw material add water with
And the onion slurry decocts, the temperature for being cooled to decoction thing adds Bifidobacterium and just ferment after being 25-30 DEG C, described initial
Filtered after ferment, obtain the first extracting solution and first dregs of a decoction；First dregs of a decoction alcohol reflux of 30-50vol% is extracted, is obtained
To the second extracting solution and second dregs of a decoction；
The fermentation includes：It is concentrated in vacuo after first extracting solution and second extracting solution are mixed, obtains relative density
For the clear cream of 1.05-1.1；Saccharomycete is added in the clear cream, is subsequently placed under the conditions of temperature is 25-30 DEG C and ferments, then go out
Bacterium is handled, and obtains the first fermentation liquid；Second dregs of a decoction are placed under the conditions of temperature is 30-35 DEG C and are fermented, add water decoction
And filter, obtain the second fermentation liquid；Mix the first fermentation liquid and the second fermentation liquid.
4. the preparation method according to claim 3 for improving the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foaming foot agent, its feature
It is, the weight ratio of the medicinal raw material and the ethanol of the 30-50vol% is 1:5-10.
5. the preparation method according to claim 3 for improving the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foaming foot agent, its feature
It is, the temperature of the refluxing extraction is 30-50 DEG C, time 2-3h.
6. the preparation method according to claim 3 for improving the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foaming foot agent, its feature
It is, the concentration of the saccharomycete in the clear cream is 1 × 104-105CFU/g。
7. the preparation method according to claim 3 for improving the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foaming foot agent, its feature
It is, the fermentation time of the clear cream is 24-48h.
8. the preparation method according to claim 3 for improving the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foaming foot agent, its feature
It is, the time of second dregs of a decoction fermentation is 24-48h.
9. the preparation method according to claim 3 for improving the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foaming foot agent, its feature
It is, the time that first medicinal raw material adds water to cook is 1-3h, and the fermentation temperature for decocting thing is 25-30 DEG C, described
The fermentation time for decocting thing is 24-36h.
10. the preparation method according to claim 3 for improving the powerless Chinese medicine of kidney deficiency, pain in the back, leg knee and foaming foot agent, its feature
It is, pulvis, granule, aqua or paste is made after the described first fermentation liquid and the second fermentation liquid are mixed.
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Application publication date: 20180508 |