CN104383189B - Chinese medicinal granules for treating enuresis of children and method for preparing same - Google Patents

Chinese medicinal granules for treating enuresis of children and method for preparing same Download PDF

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CN104383189B
CN104383189B CN201410718545.6A CN201410718545A CN104383189B CN 104383189 B CN104383189 B CN 104383189B CN 201410718545 A CN201410718545 A CN 201410718545A CN 104383189 B CN104383189 B CN 104383189B
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semen
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江志强
卢玲玲
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江志强
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses Chinese medicinal granules for treating enuresis of children and a method for preparing the same, belonging to the field of traditional Chinese medicines. The Chinese medicinal granules are prepared from the following raw materials (effective components): phoenix-tail fern, broad beans, seeds of Chinese waxgourd, tribulus terrestris, humifuse euphorbia herb, calamus tetradactylus, trlophora yunnanensis schitr, nelumbo nucifera gaertn, tartarian buckwheat roots and rhizome, ginkgo seeds, water chestnut, common yellow oxalis herb, jasminum laurifolium, honeycomb, ramose scouring rush herb and ficus pumila. The raw materials for preparing the Chinese medicinal granules are combined reasonably according to the theories of traditional Chinese medicine and modern medicine. The Chinese medicinal granules have the efficacies of invigorating the spleen, restoring consciousness, tonifying the kidney to hold qi, reinforcing qi and nourishing blood, has an extraordinary and significant effect of treating the enuresis of children, can take effect quickly in a short course of treatment, is free of relapse, is safe and practical, can not cause any side or toxic effect, can treat both symptoms and root causes, and the ill child can study and live normally in the period of taking the Chinese medicinal granules, thus the Chinese medicinal granules are worthy of popularization and application.

Description

A kind of Chinese medicinal granule and preparation method for the treatment of infantile enuresis
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicinal granule and preparation method for the treatment of infantile enuresis.
Background technology
Infantile enuresis is a general phenomenon, and most head of a family and some doctors do not think that bed-wetting is a kind of disease, also without the need to special treatment for a long time.And the expert specializing in infantile enuresis thinks, child wets the bed and should not ignore.Infantile nervous frequent micturition, refer to non-infectious frequent micturition, urgent micturition, be department of pediatrics one independence disease feature, frequent micturition, every 3 ~ 19 minutes once, about 4 ~ 6 times per hour of most infant.Urgent micturition, says and wants urine to have no patience a moment.Clinically be divided into primary enuresis and secondary enuresis two kinds, the former refers to the lasting or lasting enuresis, and the period controlling therebetween to urinate was never greater than 1 year; The latter refers to that children's controls to urinate at least 1 year, but continue after there is the enuresis again.
Constantly perfect along with nervous system development, the bladder of normal infant and child can self-assembling formation to the control of urinating, and does not need special guidance and training.If but repeatedly there is unconscious afterwards urinating of falling asleep in the child of more than 5 years old or 5 years old, reaches weekly more than 2 times and continue at least 6 months, then without this phenomenon under waking state, then should be regarded as exception, being referred to as constitutional nocturnal enuresis disease clinically.After wetting the bed, infant is endured cold by wet, and evening is not sleep well, activity on daytime fatiguability, and study is a cup too low, sometimes blame by others, ridicule in the course of time by friend, heart is subject to grievous injury, makes to move from little active love, talkative child becomes introverted, becomes irritable, and personality is eccentric; Become timid, though the enuresis is not the serious disease what is killed, he can affect between child and associate, and affects the life of infant sleep learning, and affect the development of child's brain intelligence, it is a kind of Silent Killer.
Child's majority of wetting the bed all have have a delicate constitution, can not note upper class hour paying attention to the class, the feature of school grade difference, but the head of a family can not pay attention to, and can affect the physical and mental health of child.The medicine of current western medicine infantile enuresis is more, but therapeutic effect is undesirable, easily recurs, and be difficult to the object of accomplishing to effect a radical cure infantile enuresis, and Chinese medicine has great advantage, short treating period, instant effect, has no side effect, and can reach the object for the treatment of both the principal and secondary aspects of a disease.
Summary of the invention
The invention provides a kind of Chinese medicinal granule and preparation method for the treatment of infantile enuresis; Selected by Chinese medicinal granule of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of spleen invigorating refreshment, improving inspiration by invigorating the kidney, benefiting QI and nourishing blood, to treatment infantile enuresis, there is significant curative effect, short treating period, instant effect, non-relapse after healing, safe without toxic side effect, period in a medicine can normal studying and living, special effect is practical, and treating both the principal and secondary aspects of a disease, should be widely promoted application.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicinal granule for infantile enuresis, raw material composition and the parts by weight of making described Chinese medicinal granule effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicinal granule effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicinal granule effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicinal granule effective ingredient are:
Treat a preparation method for the Chinese medicinal granule of infantile enuresis, comprise following processing step:
(1) Herba Pteridis Multifidae, Semen Ginkgo, Corm Eleocharitis and Caulis fici pumilae (Fructus Fici Pumilae) are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Semen Viciae fabae, Semen Benincasae, Radix Tylophorae Yunnanensis and Nidus Vespae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(3) Fructus Tribuli, Stamen Nelumbinis, Herba Oxalidis Strictae, Herba Jasmini laurifolii and Herba equiseti ramosissimi are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(4) Herba Euphorbiae Humifusae, Herba Calami tetradactyli and Radix Et Rhizoma Fagopyri Tatarici are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) by juice, fine powder and the thick paste mixing obtained by above-mentioned steps (1) ~ (4), make granule, obtain the Chinese medicinal granule for the treatment of infantile enuresis of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Pteridis Multifidae: lightly seasoned, micro-hardship, cold in nature; Return large intestine, the heart, Liver Channel.Clearing away heat-damp and promoting diuresis, removing toxic substances dysentery relieving, cooling blood for hemostasis.For dysentery, gastroenteritis, hepatitis, urinary system infection, cat fever, laryngopharynx swelling and pain, leucorrhea, metrorrhagia, pesticide intoxication; Traumatic hemorrhage is controlled in external, burn and scald." will planted by Guangxi medicine " carries: " clear large intestine, lung-heat.Control hot bloody dysentery and toothache, emesis blood.”
Semen Viciae fabae: sweet in the mouth, micro-pungent, property is put down; Return spleen, stomach, heart channel.Invigorating spleen for diuresis, removing toxic substances and promoting subsidence of swelling.Main diaphragm food, edema, sore." Hunan medicine will " carries; " spleen invigorating, hemostasis, diuresis.”
Semen Benincasae: sweet in the mouth, cold nature; Return lung, large intestine channel.Lung heat clearing, reduces phlegm, evacuation of pus.Be applicable to cough due to lung-heat, lung abscess, the diseases such as acute appendicitis." Shandong Chinese medicine " carries: " control nephritis, urethritis, dysuria, beriberi, edema.”
Fructus Tribuli: bitter in the mouth, pungent, warm in nature; Enter liver, lung meridian.Loose wind improving eyesight, therapeutic method to keep the adverse QI flowing downwards promoting the circulation of blood.Main headache, dizzy, distending pain in the chest and hypochondrium, distending pain of the breast, breast closes obstructed, amenorrhea, cataract, rubella pruritus, vitiligo, skin ulcer cellulitis, scrofula." not Lu " carries: " main health pruritus due to wind pathogen, headache, cough with dyspnea impairing the lung, consumptive lung disease, only tired, the therapeutic method to keep the adverse QI flowing downwards; Children's's head sore, the cloudy Huang of carbuncle, can rub powder.”
Herba Euphorbiae Humifusae: acrid in the mouth, property is put down; Return lung, liver, stomach, large intestine, urinary bladder channel.Heat-clearing and toxic substances removing, dampness removing jaundice eliminating, promoting blood circulation and hemostasis.Cure mainly dysentery, have loose bowels, jaundice, hemoptysis, spit blood, hematuria, has blood in stool, metrorrhagia, agalactia, treating swelling and pain by traumatic injury and pathopyretic ulcer." Chinese herbal medicine is commonly used in Shanghai ": carry: " hemostasis, diuresis, stomach invigorating, promoting blood circulation and detoxication.Harness the Yellow River subcutaneous ulcer, dysentery, diarrhoea, urinary tract infection, has blood in stool, hematuria, metrorrhagia, bleeding hemorrhoids, treating swelling and pain by traumatic injury, woman's galactostasis, venom, head sore, skin sore.”
Herba Calami tetradactyli: bitter in the mouth, micro-salty, hot in nature, poisonous; Return liver, lung meridian.Diaphoresis is dispeled the wind, promoting blood circulation and hemostasis.Cure mainly anemofrigid cold, rheumatoid arthritis, traumatic injury, amenorrhea, traumatic hemorrhage." Yunnan Chinese herbal medicine " carries: " hemostasis, synthetism, diaphoresis, dispels the wind.”
Radix Tylophorae Yunnanensis: bitter in the mouth, pungent; Slightly warm in nature; Return liver, spleen channel.Kuai, a state in the Zhou Dynasty dish dredging collateral, promoting blood circulation and stopping pain.Main rheumatic ostalgia hepatitis, gastric ulcer, poliomyelitis sequela, traumatic injury." Yunnan Chinese herbal medicine " carries: " relaxing muscles and tendons to promote blood circulation, menstruction regulating and pain relieving.Control traumatic injury, rheumatic ostalgia, hepatitis, gastric ulcer, chronic consumptive disease, pernicious malaria.”
Stamen Nelumbinis: sweet in the mouth, puckery, property is put down; GUIXIN, kidney channel.Reinforcing the kindey to control nocturnal emission.For emission and spermatorrhea, leukorrhagia, frequent micturition." book on Chinese herbal medicine is new again " carries: " deficiency-heat of the lung that clears away heart-fire, expelling summer-heat relieving restlessness, promoting the production of body fluid to quench thirst.”
Radix Et Rhizoma Fagopyri Tatarici: sweet in the mouth, property is put down, and mild toxicity, returns spleen, stomach, large intestine channel.Spleen invigorating row is stagnant, regulating QI to relieve pain, removing toxic substances and promoting subsidence of swelling.Cure mainly epigastric distending pain, dyspepsia, dysentery, lumbago and skelalgia, traumatic injury, carbuncle malignant boil, lyssodexis." Inner Mongol Chinese herbal medicine " carries: " removing damp and stopping pain, removing toxic substances and promoting subsidence of swelling, stomach invigorating.Control traumatic injury, lumbago and skelalgia, sore and toxic, dyspepsia.”
Semen Ginkgo: sweet in the mouth, hardship, puckery, property is put down; Return lung meridian.Astringing lung QI for relieving asthma, leukorrhagia stopping is turbid, urine reducing.Breath with cough for abundant expectoration, leukorrhagia nebulousurine, enuresis frequent micturition." book on Chinese herbal medicine is new again " carries: " QI invigorating nourishes heart, kidney tonifying YIN nourishing, cough-relieving relieving restlessness, and granulation promoting is put on flesh, and evacuation of pus is drawn out pus by applying a plaster to the affected part, the skin ulcer that disappears scabies cellulitis tumor.”
Corm Eleocharitis: sweet in the mouth, cold in nature, nontoxic.Promoting the production of body fluid for nourishing the lung, reduce phlegm sharp intestinal, diuresis promoting, and eliminating carbuncle detoxifies, and removing heat from blood removing dampness, help digestion de-swelling.Cure mainly calentura to quench one's thirst, jaundice, conjunctival congestion, laryngopharynx swelling and pain, urine red heat is deficient, affection due to external wind and heat, the diseases such as mass in the abdomen.Modern medicine study confirms, Corm Eleocharitis all has certain inhibitory action to staphylococcus aureus, escherichia coli and bacillus pyocyaneus, and the heat that can disappear removes expectorant, reduces blood pressure.
Herba Oxalidis Strictae: bitter in the mouth, cold in nature; GUIXIN, Liver Channel.Parasite killing pain relieving, heat radiation detumescence, blood stasis dispelling.The filaricide initial stage is controlled in decoction, gonorrhea, traumatic injury; Smash to apply and control toxic swelling, burn, scabies.
Herba Jasmini laurifolii: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, antiinflammatory diuresis, detumescence dissipating blood stasis.Cure mainly dysentery, urinary tract infection, cystitis, oedema due to nephritis, traumatic injury, bruise.
Nidus Vespae: sweet in the mouth, property is put down; Return stomach warp.Dispel the wind counteracting toxic substances, parasite killing pain relieving, antiallergic." choosing of Simao, Yunnan Chinese herbal medicine " carries: " relaxing muscles and tendons and activating QI and blood in the collateral, method rheumatism, diuresis.Treating rheumatic arthritis, waist knee joint arthralgia chiefly caused by damp pathogen, oedema due to nephritis.”
Herba equiseti ramosissimi: sweet in the mouth, hardship, property is put down, is slightly cold, nontoxic; GUIXIN, liver, stomach, urinary bladder channel.Liver heat removing and eyesight improving, hemostasis, inducing diuresis for treating stranguria syndrome.Main anemopyretic cold, cough, conjunctival congestion and swelling pain, nebula, epistaxis, hematuria, discharging fresh blood stool, stranguria, jaundice, leukorrhagia, fracture." Traditional Chinese Medicine in Sichuan will " carries: " clearing away heart-fire, removes hectic fever, scattered clouds nebula.Control epidemic hemorrhagic conjunctivitis, puckery pain, overflow tear and conjunctival congestion and swelling pain, and treat nose bleeding.”
Caulis fici pumilae (Fructus Fici Pumilae): sour in the mouth, cool in nature.Expelling wind and removing dampness, promoting blood circulation and detoxication.Dispelling the wind and dampness pathogens arthralgia pain, dysentery, gonorrhea, traumatic injury, carbuncle furuncle." Hunan medicine will " carries: " heat-clearing and toxic substances removing, damp eliminating diuresis.Control filaricide, traumatic injury, lumbago, hematodiarrhoea, watery diarrhea, pyretic stranguria, tripe flatulence falls.”
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicinal granule of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of spleen invigorating refreshment, improving inspiration by invigorating the kidney, benefiting QI and nourishing blood, to treatment infantile enuresis, there is significant curative effect, short treating period, instant effect, non-relapse after healing, safe without toxic side effect, period in a medicine can normal studying and living, special effect is practical, and treating both the principal and secondary aspects of a disease, should be widely promoted application.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicinal granule effective ingredient of the present invention and weight are:
Treat a preparation method for the Chinese medicinal granule of infantile enuresis, comprise following processing step:
(1) Herba Pteridis Multifidae, Semen Ginkgo, Corm Eleocharitis and Caulis fici pumilae (Fructus Fici Pumilae) are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Semen Viciae fabae, Semen Benincasae, Radix Tylophorae Yunnanensis and Nidus Vespae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(3) Fructus Tribuli, Stamen Nelumbinis, Herba Oxalidis Strictae, Herba Jasmini laurifolii and Herba equiseti ramosissimi are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(4) Herba Euphorbiae Humifusae, Herba Calami tetradactyli and Radix Et Rhizoma Fagopyri Tatarici are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) by juice, fine powder and the thick paste mixing obtained by above-mentioned steps (1) ~ (4), make granule, obtain the Chinese medicinal granule for the treatment of infantile enuresis of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 1 (every 0.5g), warm water delivery service after meal; Within 5 days, be 1 course for the treatment of, 1 ~ 3 course for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese medicinal granule effective ingredient of the present invention and weight are:
The Chinese medicinal granule preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicinal granule effective ingredient of the present invention and weight are:
The Chinese medicinal granule preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicinal granule effective ingredient of the present invention and weight are:
The Chinese medicinal granule preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of Chinese medicinal granule effective ingredient of the present invention and weight are:
The Chinese medicinal granule preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicinal granule for the treatment of infantile enuresis, select the routine clinical observation of infantile enuresis infant 236 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 118 example, wherein boy 59 example, young girl 59 example, 2 ~ 11 years old age, 6.5 years old mean age, average course of disease 1 year; Matched group 118 example, wherein boy 59 example, young girl 59 example, 3 ~ 10 years old age, 6.5 years old mean age, average course of disease 1 year.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes Chinese medicinal granule of the present invention, oral, every day 2 times, each 1 time sooner or later, each 1 (every 0.5g), warm water delivery service after meal; Within 5 days, be 1 course for the treatment of, 1 ~ 3 course for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes atropine, oral, and by body weight 0.01mg/kg, within every 4 ~ 6 hours, once the course for the treatment of is depending on the state of an illness.
3, efficacy determination:
(1) cure: above-mentioned symptom all disappears, and physical recovery is normal.
(2) effective: above-mentioned symptom obviously alleviates, health takes a turn for the better to some extent.
(3) effective: above-mentioned symptom alleviates to some extent, and health is clearly better.
(4) invalid: by treating rear above-mentioned symptom without alleviating or increasing the weight of.
4, result:
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, journey, female, 8 years old, people from Baodi District, Tianjin.Infant fear of cold, pale, attending class, it is dynamic to like, absent minded, school grade is on the lower side, since account, wet the bed and annoying infant always, invalid through multi-treatment, rear to our hospital, be diagnosed as infantile enuresis, take Chinese medicinal granule of the present invention treatment, after taking 1 course for the treatment of, symptom alleviates, after continuing to take 1 course for the treatment of, transference cure, recovery from illness.
2, Cao, man, 5 years old, Spring in Pig House of Shanghai Fengxian people from district.Infant is wet the bed from little always, father and mother look at child has this defect anxious at heart, go to our hospital, be diagnosed as infantile enuresis, give Chinese medicinal granule of the present invention treatment, after taking 1 course for the treatment of, symptom is clearly better, and after continuing to take 2 courses for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to after 1 year without recurrence.
3, Yuan, female, 6 years old, Chongqing Jiangbei people from district.Infant is all wet the bed from small to large always, do not stop, the head of a family is sorely distressed, and uses several drugs to treat, have no improvement, by taking Chinese medicinal granule of the present invention treatment, after taking 1 course for the treatment of, symptom alleviates to some extent, after continuing to take 1 course for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to without recurrence after half a year.
4, Deng, man, 4 years old, Heilungkiang grand celebration people.Infant is wet the bed, and have weekly bed-wetting in 3 ~ 4 days, school grade is poor, takes Chinese medicinal granule of the present invention treatment, after taking 1 course for the treatment of, symptom is obviously alleviated, after taking 2 courses for the treatment of, and transference cure, recovery from illness, follows up a case by regular visits to so far without recurrence, and can note upper class hour paying attention to the class, and school grade improves a lot.
5, certain is permitted, female, 7 years old, people from Jilin songyuan.Infant was just often wet the bed from three years old, a similar week must urinate four or five times, and that also sleeps evening heavyly especially cries yet, through infants ' parents private prosecution from two or three years old with regard to not yum-yum meal, body constitution is bad frequent cat fever also, through taking Chinese medicinal granule of the present invention treatment, after taking 1 course for the treatment of, symptom alleviates to some extent, after continuing to take 2 courses for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to without recurrence after 1 year.
6, Fu, man, 9 years old, Heze City, Shandong Province people.Infant mother finds that son is somewhat abnormal, every evening wets the bed, sometimes daytime, also urine pants were sub, and infant mother fears that the psychology of child can be subject to bad impact, to our hospital, be diagnosed as infantile enuresis, through taking Chinese medicinal granule of the present invention treatment, after taking 1 course for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to so far without recurrence.

Claims (5)

1. treat a Chinese medicinal granule for infantile enuresis, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicinal granule effective ingredient are:
Herba Pteridis Multifidae 61 ~ 85 parts of Semen Viciae fabaes 59 ~ 83 parts of Semen Benincasaes 58 ~ 82 portions of Fructus Tribulis 58 ~ 82 parts
Herba Euphorbiae Humifusae 57 ~ 81 portions of Herba Calami tetradactylis 56 ~ 80 parts of Radix Tylophorae Yunnanensis 56 ~ 80 parts of Stamen Nelumbiniss 55 ~ 79 parts
Radix Et Rhizoma Fagopyri Tatarici 55 ~ 79 portions of Semen Ginkgoes 53 ~ 77 portions of Corm Eleocharitiss 52 ~ 76 parts of Herba Oxalidis Strictaes 52 ~ 76 parts
Herba Jasmini laurifolii 50 ~ 74 parts of Nidus Vespae 49 ~ 73 parts of Herba equiseti ramosissimis 46 ~ 70 parts of Caulis fici pumilae (Fructus Fici Pumilae)s 41 ~ 65 parts.
2. a kind of Chinese medicinal granule for the treatment of infantile enuresis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicinal granule effective ingredient are:
Herba Pteridis Multifidae 65 ~ 81 parts of Semen Viciae fabaes 63 ~ 79 parts of Semen Benincasaes 62 ~ 78 portions of Fructus Tribulis 62 ~ 78 parts
Herba Euphorbiae Humifusae 64 ~ 77 portions of Herba Calami tetradactylis 60 ~ 76 parts of Radix Tylophorae Yunnanensis 60 ~ 76 parts of Stamen Nelumbiniss 59 ~ 75 parts
Radix Et Rhizoma Fagopyri Tatarici 59 ~ 75 portions of Semen Ginkgoes 57 ~ 73 portions of Corm Eleocharitiss 56 ~ 72 parts of Herba Oxalidis Strictaes 56 ~ 72 parts
Herba Jasmini laurifolii 54 ~ 70 parts of Nidus Vespae 53 ~ 69 parts of Herba equiseti ramosissimis 50 ~ 66 parts of Caulis fici pumilae (Fructus Fici Pumilae)s 45 ~ 61 parts.
3. a kind of Chinese medicinal granule for the treatment of infantile enuresis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicinal granule effective ingredient are:
Herba Pteridis Multifidae 69 ~ 77 parts of Semen Viciae fabaes 67 ~ 75 parts of Semen Benincasaes 66 ~ 74 portions of Fructus Tribulis 66 ~ 74 parts
Herba Euphorbiae Humifusae 65 ~ 73 portions of Herba Calami tetradactylis 64 ~ 72 parts of Radix Tylophorae Yunnanensis 64 ~ 72 parts of Stamen Nelumbiniss 63 ~ 71 parts
Radix Et Rhizoma Fagopyri Tatarici 63 ~ 71 portions of Semen Ginkgoes 61 ~ 69 portions of Corm Eleocharitiss 59 ~ 68 parts of Herba Oxalidis Strictaes 60 ~ 68 parts
Herba Jasmini laurifolii 58 ~ 66 parts of Nidus Vespae 57 ~ 65 parts of Herba equiseti ramosissimis 54 ~ 62 parts of Caulis fici pumilae (Fructus Fici Pumilae)s 49 ~ 57 parts.
4. a kind of Chinese medicinal granule for the treatment of infantile enuresis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicinal granule effective ingredient are:
Herba Pteridis Multifidae 73 parts of Semen Viciae fabaes 71 parts of Semen Benincasaes 70 portions of Fructus Tribulis 70 parts
Herba Euphorbiae Humifusae 69 portions of Herba Calami tetradactylis 68 parts of Radix Tylophorae Yunnanensis 68 parts of Stamen Nelumbiniss 67 parts
Radix Et Rhizoma Fagopyri Tatarici 67 portions of Semen Ginkgoes 65 portions of Corm Eleocharitiss 65 parts of Herba Oxalidis Strictaes 64 parts
Herba Jasmini laurifolii 62 parts of Nidus Vespae 61 parts of Herba equiseti ramosissimis 58 parts of Caulis fici pumilae (Fructus Fici Pumilae)s 53 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for the Chinese medicinal granule of infantile enuresis, it is characterized in that: comprise following processing step:
(1) Herba Pteridis Multifidae, Semen Ginkgo, Corm Eleocharitis and Caulis fici pumilae (Fructus Fici Pumilae) are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Semen Viciae fabae, Semen Benincasae, Radix Tylophorae Yunnanensis and Nidus Vespae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(3) Fructus Tribuli, Stamen Nelumbinis, Herba Oxalidis Strictae, Herba Jasmini laurifolii and Herba equiseti ramosissimi are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(4) Herba Euphorbiae Humifusae, Herba Calami tetradactyli and Radix Et Rhizoma Fagopyri Tatarici are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) by juice, fine powder and the thick paste mixing obtained by above-mentioned steps (1) ~ (4), make granule, obtain the Chinese medicinal granule of described treatment infantile enuresis.
CN201410718545.6A 2014-11-29 2014-11-29 Chinese medicinal granules for treating enuresis of children and method for preparing same Expired - Fee Related CN104383189B (en)

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