CN104435860B - Traditional Chinese medicinal preparation for treating infantile upper respiratory infection and preparation method of traditional Chinese medicinal preparation - Google Patents

Traditional Chinese medicinal preparation for treating infantile upper respiratory infection and preparation method of traditional Chinese medicinal preparation Download PDF

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CN104435860B
CN104435860B CN201410797518.2A CN201410797518A CN104435860B CN 104435860 B CN104435860 B CN 104435860B CN 201410797518 A CN201410797518 A CN 201410797518A CN 104435860 B CN104435860 B CN 104435860B
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herba
chinese medicine
traditional chinese
medicine preparation
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CN104435860A (en
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李霞
李春玲
刘兴香
冉焕英
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/13—Coniferophyta (gymnosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a traditional Chinese medicinal preparation for treating infantile upper respiratory infection and a preparation method of the traditional Chinese medicinal preparation, and belongs to the field of traditional Chinese medicine. The active ingredients of the traditional Chinese medicinal preparation are prepared from the following raw materials: yichang meadow rue, root of kudzu vine, aloe leaf, Japanese polygala, lissorhoptrus oryzophilus kus, lotus root, remote lemongrass herb, folium callicarpae pedunculalae, radix crepidis ligneae, canarium pimela, sophora flower, leontopodium alpinum, sugarcane, platycladi seed, pear peel and semen torreya. The traditional Chinese medicinal preparation disclosed by the invention is appropriate in compatibility of the selected medicinal materials, and consistent with the principles of traditional Chinese medicine and modern medicine; the traditional Chinese medicinal preparation has functions of expelling wind to relieve exterior, clearing heat and promoting diuresis, and moistening lung to arrest cough; the preparation has a unique curative effect on treating infantile upper respiratory infection, and the preparation is significant in curative effect, free from influence on normal study and life during treatment, short in treatment course, rapid in effect taking, safe and reliable, free from toxic and side effect and capable of achieving a purpose of treating both symptoms and root causes, and is worthy of wide popularization and application.

Description

A kind of Chinese medicine preparation and preparation method for the treatment of infant upper respiratory tract infection
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation and preparation method for the treatment of infant upper respiratory tract infection.
Background technology
Upper respiratory tract infection is the common disease of infant, the flu that namely it has often been said, refer to the respiratory inflammation of the nose of top respiratory tract, pharynx and throat, " acute tonsillitis ", " acute pharyngitis " of clinical diagnosis, " acute nasopharyngitis " all belong to sense.All can fall ill throughout the year, but more when winter-spring season replaces, and infant is the most common, and often have for several times every year, Symptoms weight degree is different.Mild shows as low grade fever, watery nasal discharge, has a stuffy nose, tussiculas, sneeze, diarrhoea or slight vomiting etc., nasal mucosa congestion and edema, secretions increase, pharyngeal slightly red, cervical region or submandibular lymph nodes can silght enlargements, and the mental status is good, and natural history was at about 3 ~ 7 days.Severe one fever, is everlasting more than 39 DEG C, Symptoms is that spirit is more weak, headache, apasm of coughing, pharyngalgia, vomiting, degradation under weak, fear of cold, appetite, have obvious pharyngeal congestion, tonsil is red and swollen, submandibular lymph nodes enlargement tenderness.Inflammation also can involve middle ear, nasal sinuses and trachea, causes otitis media, sinusitis and tracheitis.Sometimes also can with stomachache, there is pain at light pressure umbilicus week position, and mostly be adenomesenteritis, if stomachache does not acutely take a turn for the better, father and mother should be with infant to hospital admission in time.
Upper respiratory tract infection is common bacteriological infection and viral infection, wherein comparatively common with viral infection.Treatment aspect can be divided because of therapy and supporting treatment.Go because of in therapy to viral infection many employings treatment by Chinese herbs.Bacterial infection is then with penicillin or other antibiotic.So must first make a definite diagnosis before treatment is viral infection or bacteriological infection, treatment is not suited the medicine to the illness, and meeting delay treatment, protracted course of disease, causes a lot of chronic disease, as chronic rhinitis, chronic pharyngitis etc.
The Chinese medicine and western medicine of current treatment upper respiratory tract infection is various in style, the large multi-component complex of western medicine, and preparation technology's difficulty is large, and therapeutic domain is narrow, and side effect is large, long-term taking, not only therapeutic effect difference but also bring to the health of child greatly to injure.
Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of infant upper respiratory tract infection; Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of dispelling wind to relieve the exterior syndrome, clearing away heat-damp and promoting diuresis, nourishing the lung to arrest cough, to treatment infant upper respiratory tract infection, there is unique curative effect, and it is evident in efficacy, period in a medicine can normal studying and living, short treating period, instant effect, safe and reliable, have no side effect, can reach the object for the treatment of both the principal and secondary aspects of a disease, should be widely promoted application.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for infant upper respiratory tract infection, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Treat a preparation method for the Chinese medicine preparation of infant upper respiratory tract infection, comprise following processing step:
(1) Herba Thalictri Ichangensis, Herba leerisae hexandrae, Fructus Canarii Pimelae, Leontopodium leontopodioides (Willd.) Beauv., Semen Platycladi, Pericarpium Pyri and Semen Torreyae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) Radix Puerariae, Herba Polygalae Japonicae and Folium Callicarpae Formosanae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(3) Folium Aloe, Rhizoma Nelumbinis and Caulis Sacchari sinensis are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice, for subsequent use;
(4) Herba Cymbopogonis and Radix Crepidis Ligneae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) Flos Sophorae is put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 200 order fine powders, for subsequent use;
(6) by the filtrate obtained by above-mentioned steps (1) ~ (5), fine powder, juice and thick paste mixing, make capsule, obtain the Chinese medicine preparation for the treatment of infant upper respiratory tract infection of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Thalictri Ichangensis: bitter in the mouth, cold in nature; Return liver, stomach, large intestine channel.Heat-clearing and toxic substances removing, dampness.Cure mainly jaundice due to damp-heat, hygropyretic dysentery, infantile convulsion, conjunctival congestion and swelling pain, erysipelas urticaria, thrush, traumatic injury." will planted by middle traditional Chinese medicines " carries: " herb: cold expelling is except wind, and remove order mist, disappear edema.Control deafness, skin turning yellow.Also ascarid medicine is driven do stomach invigorating.”
Radix Puerariae: Gan Xin is flat; Enter spleen, stomach warp.Yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf." not Lu " carries: " excessive cold invading middle-JIAO(the spleen and stomach) wind headache of curing the wound, expelling pathogenic factors from muscles, delivers, and perspires, loosing the interspaces of skin and muscles.Treat incised wound, pain relieving, side of body wind pain.Take root juice, treatment is quenched one's thirst, typhoid fever high fever." modern medicine study, Radix Puerariae flavone has cancer-resisting and estrogen-like effects, can promote women's breast enlargement, skin care, especially to middle-aged women and the effect of menopausal women face-nourishing health-care obvious.
Folium Aloe: bitter and puckery flavor, cold in nature.Pathogenic fire purging is stimulated the menstrual flow, and parasite killing detoxifies.Control nebulousurine, hematuria, women's amenorrhea, leukorrhagia, pediatric epilepsy scared, infantile malnutrition, scald, hemorrhoid, scabies, carbuncle." Nanning City's medicine will " carries: " disappear infantile malnutrition with fever, and parasite killing amasss, and stimulates the menstrual flow, cool liver.Control married woman's amenorrhea, pediatric epilepsy scared, infantile malnutrition.Life external application, controls burn and mumps.”
Herba Polygalae Japonicae: taste is micro-pungent, slightly warm in nature.Promoting blood circulation to remove blood stasis, eliminating phlegm and relieving cough, removing toxic substances pain relieving.For pharyngitis, tonsillitis, stomatitis, cough, infantile pneumonia, infantile malnutrition, urinary system calculus, mastitis, osteomyelitis, venom is controlled in external, furuncle furuncle and phyma." illustrated handbook planted by middle traditional Chinese medicines " carries: " root is calm, expectorant, energy intelligent promoting and the mind tranquilizing, and fall apart strongly fragrant reducing phlegm, and disappears red swollen.Control bronchitis, pneumonia, cough ant phlegm, palpitation with fear, forgetful carbuncle skin ulcer swells, sore throat.”
Herba leerisae hexandrae: taste is put down, and property is pungent.Dispelling wind to relieve the exterior syndrome, dampness removing, removing obstruction in the collateral to relieve pain.Cure mainly flu, headache body pain, malaria, leucorrhea, lower limbs edema, dysuria, arthralgia pain is numb." Traditional Chinese Medicine in Sichuan will " carries: " energy expelling cold and relieving exterior syndrome, the meridian dredging.Treating malaria disease, flu head-body-pain.”
Rhizoma Nelumbinis: sweet in the mouth, cool in nature, main invigorating middle warmer is burnt, reposes, physical strength profiting.Energy clearing away heat and promoting production of body fluid, cooling blood for hemostasis, dissipating blood stasis blood." traditional Chinese medical science " carries: " repose, physical strength profiting." modern medicine study confirmation, the nutritive value of Rhizoma Nelumbinis is very high, is rich in the trace element such as ferrum, calcium, and phytoprotein, vitamin and content of starch are also very abundant, have obvious benefiting vital QI and blood, strengthens body immunity effect.
Herba Cymbopogonis: acrid in the mouth, hardship, warm in nature.Induce sweat, dampness removing, relievings asthma, cough-relieving.The summer-heat that cures the wound is caught a cold, and gonorrhea, rheumatism muscles and bones is ached, chronic tracheitis." Kunming conventional medical herbs among the people " carries: " heat-clearing and toxic substances removing expelling summer-heat, fragrant stomach invigorating.Control the mute pain of throat, heatstroke, gastral cavilty is satisfied vexed, and sore festers.”
Folium Callicarpae Formosanae: bitter in the mouth, puckery, property is put down.Hemostasis, dissipating blood stasis, antiinflammatory.For epistaxis, spitting of blood, gastrointestinal hemorrhage, metrorrhagia, upper respiratory tract infection, tonsillitis, pneumonia, bronchitis; Traumatic hemorrhage is controlled in external, burn." illustrated handbook planted by middle traditional Chinese medicines " carries: " hemorrhage to esophageal vein, intestine gastric ulcer is hemorrhage, epistaxis, wound hemorrhage, pneumorrhagia and have tooth pulled out and hemorrhagely all have good effect.”
Radix Crepidis Ligneae: bitter in the mouth, micro-sweet, property is put down.Spleen invigorating removing food stagnancy, heat-clearing and toxic substances removing, stimulating milk secretion.For infantile malnutrition,
Hypogalactia, bronchitis, pneumonia, hepatitis, leucorrhea, discharging fresh blood stool, bones and muscles pain, traumatic injury, furuncle carbuncle." choosing of Yunnan Chinese herbal medicine " carries: " nourishing the lung to arrest cough, heat-clearing and toxic substances removing help digestion and regulate the flow of vital energy, lactogenic.Control bronchitis, pneumonia, carbuncle, infantile malnutrition, hypogalactia, conjunctivitis.”
Fructus Canarii Pimelae: sour in the mouth, puckery, property is put down; Return spleen, lung meridian.Relaxing muscles and tendons and activating QI and blood in the collateral, damp eliminating of dispeling the wind, heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For lumbago, skelalgia of rheumatism, numb hand and foot, flu, inflammation of upper respiratory tract, pneumonia, multiple furuncle and phyma." south of the Five Ridges gather medicinal herbs record " carries: " sustainability forged by fire, hemostasis and phlegm.Few salting it, name olive fermented soya beans, salted or other wise, acute mastitis from the beginning of, decoct can disappearing of washing.”
Flos Sophorae: bitter in the mouth, cold nature; Enter liver, lung, the heart, large intestine channel.Cooling blood for hemostasis, liver heat removing and eyesight improving.Cure mainly discharging fresh blood stool, hemorrhoid hematochezia, dysentery, hematuria, stranguria with blood, metrorrhagia, spit blood, epistaxis, liver-heat is had a headache, conjunctival congestion and swelling pain, carbuncle skin infection." book on Chinese herbal medicine just " carries: " cool large intestine kills infantile malnutrition worm.Control skin sore, erosion of vulva pruritus due to damp pathogen, anal fistula, separate Fructus Myricae rubrae malignant boil, primary sore volt poison." modern medicine study confirms, the globulariacitrin contained by Flos Sophorae can strengthen capillary resistance, improves blood vessel wall fragility, reduces blood pressure, edema, hypertension is had to the effect preventing rupture of blood vessel in brain, also has antiinflammatory action in addition.
Leontopodium leontopodioides (Willd.) Beauv.: mildly bitter flavor, cold in nature.Wind and heat dispersing, diuresis is stopped blooding.Cure mainly influenza, acute and chronic nephritis, urinary tract infection, hematuria, wound hemorrhage.
Caulis Sacchari sinensis: sweet in the mouth, puckery, property are put down, nontoxic.Control the inferior gas and in, help temper, sharp large intestine, expectorant is quenched the thirst, except irritable feverish sensation of chest and heart, alcoholic intoxication; Also can tell regurgitation by stopping vomiting, the chest stuffiness relieving diaphragm.Modern medicine study shows, containing abundant sugar, moisture in Caulis Sacchari sinensis, in addition, also containing the material such as various vitamin, fat, protein, organic acid, calcium, ferrum be highly profitable to human metabolism.
Semen Platycladi: sweet in the mouth, property is put down; GUIXIN, kidney, large intestine channel.Tranquilizing by nourishing the heart, hidroschesis, intestine moistening.For fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation." detailed outline " carries: " nourish heart gas, and profit kidney is dry, and Fructus Alpiniae Oxyphyllae is allayed excitement; Burn drop and control scabies.”
Pericarpium Pyri: sweet in the mouth, puckery, cool in nature, nontoxic; Return lung, the heart, kidney, large intestine channel.Clearing away heart-fire and moistening the lung, pathogenic fire reducing promotes the production of body fluid, and separates sore.Cure mainly summer-heat excessive thirst, xeropulmonary cough, spit blood, dysentery, scabies, carbuncle on the back, furuncle." book on Chinese herbal medicine is new again " carries: " quench the thirst in main Tianjin, relieving restlessness is dried for clearing heart fire, nourishing kidney tonifying YIN.”
Semen Torreyae: sweet in the mouth, puckery, property is put down; Return large intestine, stomach, lung meridian.Killing insect and eliminating accumulation, moistening dryness for relaxing bowels.For ancylostome, ascarid, taeniasis, abdominal pain due to worm stagnation, infantile malnutrition, constipation." book on Chinese herbal medicine is new again " carries: " control lung-fire, spleen invigorating soil, QI invigorating is reduced phlegm, and cough-relieving is coughed, and surely breathes out to breathe heavily, eliminating blood stasis to promote regeneration of blood.”
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of dispelling wind to relieve the exterior syndrome, clearing away heat-damp and promoting diuresis, nourishing the lung to arrest cough, to treatment infant upper respiratory tract infection, there is unique curative effect, and it is evident in efficacy, period in a medicine can normal studying and living, short treating period, instant effect, safe and reliable, have no side effect, can reach the object for the treatment of both the principal and secondary aspects of a disease, should be widely promoted application.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Treat a preparation method for the Chinese medicine preparation of infant upper respiratory tract infection, comprise following processing step:
(1) Herba Thalictri Ichangensis, Herba leerisae hexandrae, Fructus Canarii Pimelae, Leontopodium leontopodioides (Willd.) Beauv., Semen Platycladi, Pericarpium Pyri and Semen Torreyae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) Radix Puerariae, Herba Polygalae Japonicae and Folium Callicarpae Formosanae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(3) Folium Aloe, Rhizoma Nelumbinis and Caulis Sacchari sinensis are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice, for subsequent use;
(4) Herba Cymbopogonis and Radix Crepidis Ligneae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) Flos Sophorae is put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 200 order fine powders, for subsequent use;
(6) by the filtrate obtained by above-mentioned steps (1) ~ (5), fine powder, juice and thick paste mixing, make capsule, obtain the Chinese medicine preparation for the treatment of infant upper respiratory tract infection of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 1 (every 0.3g), after meal warm water delivery service or water-solublely to take; Within 2 ~ 6 days, can fully recover, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of infant upper respiratory tract infection, select the routine clinical observation of infant upper respiratory tract infection patient 104 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 52 example, wherein boy 26 example, young girl 26 example, 1 ~ 12 years old age, 6.5 years old mean age, average course of disease 1 month; Matched group 52 example, wherein boy 26 example, young girl 26 example, 1 ~ 12 years old age, 6.5 years old mean age, average course of disease 1 month.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 1 (every 0.3g), after meal warm water delivery service or water-solublely to take; Within 2 ~ 6 days, can fully recover, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group is taken children's and to be rejuvenated ball, chews clothes, is grown up one time 1.2 ~ 2.4 grams (by lactein), 3 times on the one; Children's one time 0.4 ~ 0.8 gram (by lactein), 3 times on the one.
3, efficacy determination:
(1) cure: symptom all disappears, indices recovers normal.
(2) effective: symptom is obviously improved, indices takes a turn for the better to some extent.
(3) effective: symptom makes moderate progress, and indices is clearly better.
(4) invalid: by treating rear symptom without alleviating or increasing the weight of.
4, result:
Select in the treatment group of Chinese medicine preparation of the present invention, cure 30 examples, effective 14 examples, effective 7 examples, invalid 1 example, cure rate 57.7%, total effective rate 98.1%.
20 examples are cured, effective 13 examples, effective 8 examples, invalid 11 examples, cure rate 16.7%, total effective rate 55.8% in matched group.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Jiang, man, 5 years old, people from Yunnan Yuxi.Patient's continuous 2 days sneeze, cough, heating, body temperature 39.5 DEG C, goes examination in hospital to find to suffer from infant upper respiratory tract infection, through taking Chinese medicine preparation of the present invention treatment, after taking 1 day, symptom takes a turn for the better to some extent, and body temperature decreases, after continuing to take 2 days, transference cure, temperature recovery is normal.
2, Wei, female, 7 years old, people from Bengbu.Patient's pharyngalgia, with heating, body temperature 39 DEG C, check and find that there are canescence herpes and table ulcer in pharynx and tonsil surface, around around blush, be diagnosed as infant upper respiratory tract infection, through taking Chinese medicine preparation of the present invention treatment, after taking 2 days, symptom takes a turn for the better to some extent, and temperature recovery is normal, after continuing to take 2 days, symptom all disappears, and physical recovery is normal.
3, leaf, man, 3 years old, people from Liaoyuan, Jilin.Patient's flu also with diarrhoea, removes hospital admission, is diagnosed as infant upper respiratory tract infection, and take Chinese medicine preparation of the present invention treatment through doctor advised, after taking 1 day, symptom is clearly better, after taking 2 courses for the treatment of, and transference cure, recovery from illness.
4, Xue, man, 8 years old, Xiangtan, Hunan Province people.Patient generates heat after suffering from cold before 2 days, body temperature 40.3 DEG C, and wake tears matter is clear, nasal obstruction sneeze, and took Drug therapy, effect is general.Examine see high heat, watery nasal discharge yellow thick, cough expectorant is few, red tongue with thin and yellow fur, floating and rapid pulse.Have a medical check-up: t39.5 DEG C, swallow red, antiadoncus i degree, routine blood test is without exception, is diagnosed as infant upper respiratory tract infection, take Chinese medicine preparation of the present invention treatment, after taking 2 days, body temperature decreases, and cough alleviates, after continuing to take 3 days, above-mentioned symptom all disappears, and temperature recovery is normal, recovery from illness.
5, the Yan, female, 4 years old, Henan flat-top recluse.Patient's watery nasal discharge, low grade fever 1 day, cough, tears accompany each other.Pharyngeal cavity is slightly red and swollen, both sides antiadoncus, slightly congested, dry cough is frequent, and two pulmonary respiration sounds are clear, red tongue, yellow and thin fur, floating and rapid pulse is held concurrently sliding real, is diagnosed as infant upper respiratory tract infection, takes after Chinese medicine preparation of the present invention treatment takes 2 days, symptom is obviously improved, after taking 3 skies, symptom all disappears, recovery from illness.
6, the summer, female, 10 years old, people from Zhangye, Gansu.Patient generates heat 1 day, temperature 39.3 DEG C, cough, abundant expectoration, color white matter is rare, gurgling with sputum, receive food still can, uneasy sleeping at night, light red tongue, tongue is greasy in vain, is diagnosed as infant upper respiratory tract infection, take Chinese medicine preparation of the present invention treatment, after taking 1 day, symptom is alleviated to some extent, sleep night peace and, body temperature takes a turn for the better to some extent, after continuing to take 3 days, transference cure, temperature recovery is normal, recovery from illness.

Claims (5)

1. treat a Chinese medicine preparation for infant upper respiratory tract infection, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Herba Thalictri Ichangensis 40 ~ 63 parts of Radix Puerariaes 37 ~ 61 parts of Folium Aloes 36 ~ 60 parts of Herba Polygalae Japonicae 34 ~ 58 parts
Herba leerisae hexandrae 32 ~ 56 parts of Rhizoma Nelumbiniss 30 ~ 54 parts of Herba Cymbopogoniss 29 ~ 53 portions of Folium Callicarpae Formosanaes 28 ~ 52 parts
Radix Crepidis Ligneae 25 ~ 49 portions of Fructus Canarii Pimelaes 24 ~ 48 parts of Flos Sophoraes 21 ~ 45 parts of Leontopodium leontopodioides (Willd.) Beauv. 19 ~ 43 parts
Caulis Sacchari sinensis 17 ~ 41 parts of Semen Platycladi 15 ~ 38 parts of Pericarpium Pyri 15 ~ 34 portions of Semen Torreyaes 12 ~ 30 parts.
2. a kind of Chinese medicine preparation for the treatment of infant upper respiratory tract infection according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Herba Thalictri Ichangensis 43 ~ 59 parts of Radix Puerariaes 41 ~ 57 parts of Folium Aloes 40 ~ 56 parts of Herba Polygalae Japonicae 38 ~ 54 parts
Herba leerisae hexandrae 36 ~ 52 parts of Rhizoma Nelumbiniss 34 ~ 50 parts of Herba Cymbopogoniss 33 ~ 49 portions of Folium Callicarpae Formosanaes 32 ~ 48 parts
Radix Crepidis Ligneae 29 ~ 45 portions of Fructus Canarii Pimelaes 28 ~ 44 parts of Flos Sophoraes 25 ~ 41 parts of Leontopodium leontopodioides (Willd.) Beauv. 23 ~ 39 parts
Caulis Sacchari sinensis 21 ~ 37 parts of Semen Platycladi 19 ~ 34 parts of Pericarpium Pyri 18 ~ 30 portions of Semen Torreyaes 15 ~ 27 parts.
3. a kind of Chinese medicine preparation for the treatment of infant upper respiratory tract infection according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Herba Thalictri Ichangensis 47 ~ 55 parts of Radix Puerariaes 45 ~ 53 parts of Folium Aloes 44 ~ 52 parts of Herba Polygalae Japonicae 42 ~ 50 parts
Herba leerisae hexandrae 40 ~ 48 parts of Rhizoma Nelumbiniss 38 ~ 46 parts of Herba Cymbopogoniss 37 ~ 45 portions of Folium Callicarpae Formosanaes 36 ~ 44 parts
Radix Crepidis Ligneae 33 ~ 41 portions of Fructus Canarii Pimelaes 32 ~ 40 parts of Flos Sophoraes 29 ~ 37 parts of Leontopodium leontopodioides (Willd.) Beauv. 27 ~ 35 parts
Caulis Sacchari sinensis 25 ~ 33 parts of Semen Platycladi 22 ~ 30 parts of Pericarpium Pyri 21 ~ 27 portions of Semen Torreyaes 18 ~ 24 parts.
4. a kind of Chinese medicine preparation for the treatment of infant upper respiratory tract infection according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Herba Thalictri Ichangensis 51 parts of Radix Puerariaes 49 parts of Folium Aloes 48 parts of Herba Polygalae Japonicae 46 parts
Herba leerisae hexandrae 44 parts of Rhizoma Nelumbiniss 42 parts of Herba Cymbopogoniss 41 portions of Folium Callicarpae Formosanaes 40 parts
Radix Crepidis Ligneae 37 portions of Fructus Canarii Pimelaes 36 parts of Flos Sophoraes 33 parts of Leontopodium leontopodioides (Willd.) Beauv. 31 parts
Caulis Sacchari sinensis 29 parts of Semen Platycladi 26 parts of Pericarpium Pyri 24 portions of Semen Torreyaes 21 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for the Chinese medicine preparation of infant upper respiratory tract infection, it is characterized in that: comprise following processing step:
(1) Herba Thalictri Ichangensis, Herba leerisae hexandrae, Fructus Canarii Pimelae, Leontopodium leontopodioides (Willd.) Beauv., Semen Platycladi, Pericarpium Pyri and Semen Torreyae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) Radix Puerariae, Herba Polygalae Japonicae and Folium Callicarpae Formosanae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(3) Folium Aloe, Rhizoma Nelumbinis and Caulis Sacchari sinensis are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice, for subsequent use;
(4) Herba Cymbopogonis and Radix Crepidis Ligneae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) Flos Sophorae is put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 200 order fine powders, for subsequent use;
(6) by the filtrate obtained by above-mentioned steps (1) ~ (5), fine powder, juice and thick paste mixing, make capsule, obtain the Chinese medicine preparation of described treatment infant upper respiratory tract infection.
CN201410797518.2A 2014-12-19 2014-12-19 Traditional Chinese medicinal preparation for treating infantile upper respiratory infection and preparation method of traditional Chinese medicinal preparation Expired - Fee Related CN104435860B (en)

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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101829276A (en) * 2010-02-06 2010-09-15 泰一和浦（北京）中医药研究院有限公司 Traditional Chinese medicine combination for treating pneumonoconiosis and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
中医治疗小儿上呼吸道感染经验;李寿田等;《内蒙古中医药》;19980130(第01期);第20页第1栏第1段至第2栏第4段 *
焦平,贾苗先.马新云教授的清解利咽冲剂治疗小儿上呼吸道感染208例.《河北中医药学报》.1994,第9卷(第02期), *

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