CN104435860B - Traditional Chinese medicinal preparation for treating infantile upper respiratory infection and preparation method of traditional Chinese medicinal preparation - Google Patents

Traditional Chinese medicinal preparation for treating infantile upper respiratory infection and preparation method of traditional Chinese medicinal preparation Download PDF

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CN104435860B
CN104435860B CN201410797518.2A CN201410797518A CN104435860B CN 104435860 B CN104435860 B CN 104435860B CN 201410797518 A CN201410797518 A CN 201410797518A CN 104435860 B CN104435860 B CN 104435860B
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李霞
李春玲
刘兴香
冉焕英
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Abstract

The invention discloses a traditional Chinese medicinal preparation for treating infantile upper respiratory infection and a preparation method of the traditional Chinese medicinal preparation, and belongs to the field of traditional Chinese medicine. The active ingredients of the traditional Chinese medicinal preparation are prepared from the following raw materials: yichang meadow rue, root of kudzu vine, aloe leaf, Japanese polygala, lissorhoptrus oryzophilus kus, lotus root, remote lemongrass herb, folium callicarpae pedunculalae, radix crepidis ligneae, canarium pimela, sophora flower, leontopodium alpinum, sugarcane, platycladi seed, pear peel and semen torreya. The traditional Chinese medicinal preparation disclosed by the invention is appropriate in compatibility of the selected medicinal materials, and consistent with the principles of traditional Chinese medicine and modern medicine; the traditional Chinese medicinal preparation has functions of expelling wind to relieve exterior, clearing heat and promoting diuresis, and moistening lung to arrest cough; the preparation has a unique curative effect on treating infantile upper respiratory infection, and the preparation is significant in curative effect, free from influence on normal study and life during treatment, short in treatment course, rapid in effect taking, safe and reliable, free from toxic and side effect and capable of achieving a purpose of treating both symptoms and root causes, and is worthy of wide popularization and application.

Description

一种治疗小儿上呼吸道感染的中药制剂及制备方法A kind of traditional Chinese medicine preparation for treating upper respiratory tract infection in children and its preparation method

所属技术领域Technical field

本发明涉及中药领域,尤其涉及一种治疗小儿上呼吸道感染的中药制剂及制备方法。The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating upper respiratory tract infection in children and a preparation method thereof.

背景技术Background technique

上呼吸道感染是婴幼儿常见的疾病,也就是人们常说的感冒,是指上部呼吸道的鼻、咽和喉部的呼吸道炎症,临床诊断的“急性扁桃体炎”、“急性咽炎”、“急性鼻咽炎”都属于上感。一年四季都会发病,但冬春季节交替时较多,婴幼儿最多见,每年常有数次,症状表现轻重度不同。轻度症状表现为低热、流涕、鼻塞、轻咳、打喷嚏、腹泻或轻度呕吐等,鼻黏膜充血水肿,分泌物增多,咽部稍红,颈部或颌下淋巴结可轻度肿大,精神状态良好,自然病程在3~7天左右。重者体温高,常在39℃以上,症状表现为精神较弱、头痛、阵咳、咽痛、呕吐、乏力、畏寒、食欲下降等,有明显的咽部充血,扁桃体红肿,颌下淋巴结肿大压痛。炎症还可波及中耳、鼻窦和气管,引起中耳炎、鼻窦炎和气管炎。有时还会伴有腹痛,轻压脐周部位有疼痛感,多为肠系膜淋巴结炎,如果腹痛剧烈没有好转,父母应及时带婴幼儿去医院就诊。Upper respiratory tract infection is a common disease in infants and young children. Pharyngitis" all belong to the upper sense. All can fall ill all the year round, but more often when winter and spring alternate, infants and young children are the most common, often several times a year, and symptoms vary in severity. Mild symptoms include low-grade fever, runny nose, nasal congestion, mild cough, sneezing, diarrhea or mild vomiting, nasal mucosal congestion and edema, increased secretions, slightly red throat, and mild swelling of neck or submandibular lymph nodes , The mental state is good, and the natural course of the disease is about 3 to 7 days. In severe cases, the body temperature is high, often above 39°C. Symptoms include mental weakness, headache, cough, sore throat, vomiting, fatigue, chills, loss of appetite, etc., with obvious pharyngeal congestion, red and swollen tonsils, and submandibular lymph nodes. Swelling and tenderness. Inflammation can also affect the middle ear, sinuses and trachea, causing otitis media, sinusitis and tracheitis. Sometimes accompanied by abdominal pain, light pressure on the area around the navel may cause pain, mostly mesenteric lymphadenitis, if the abdominal pain is severe and does not improve, parents should take the infant to the hospital for treatment in time.

上呼吸道感染常见有细菌感染和病毒感染,其中以病毒感染较为常见。治疗方面可分去因疗法及支持疗法。去因疗法中对病毒感染多采用中药治疗。细菌性感染则用青霉素或其它抗生素。所以治疗前一定要先确诊是病毒感染或者是细菌感染,治疗不对症的话,会延误病情,迁延不愈,导致很多慢性疾病,如慢性鼻炎、慢性咽炎等。Bacterial infection and viral infection are common in upper respiratory tract infection, and virus infection is comparatively common wherein. Treatment can be divided into cause therapy and supportive therapy. In the anti-cause therapy, traditional Chinese medicine is often used for viral infection. Penicillin or other antibiotics are used for bacterial infections. Therefore, it is necessary to confirm whether it is a viral infection or a bacterial infection before treatment. If the treatment is not appropriate, the disease will be delayed and the recovery will be delayed, leading to many chronic diseases, such as chronic rhinitis and chronic pharyngitis.

目前治疗上呼吸道感染的中西药品种繁多,西药治疗大多组分复杂,制备工艺难度大,而且治疗范围窄,副作用大,长期服用,不但治疗效果差而且给儿童的身体带来极大地伤害。At present, there are many kinds of Chinese and Western medicines for the treatment of upper respiratory tract infection. Most of the Western medicines have complex components, difficult preparation process, narrow treatment range, large side effects, and long-term use. Not only the treatment effect is poor, but also bring great harm to children's health.

发明内容Contents of the invention

本发明提供了一种治疗小儿上呼吸道感染的中药制剂及制备方法;本发明中药制剂所选药材配伍相宜,符合中医药学和现代医药学理论,并具有疏风解表、清热利湿、润肺止咳之功效,对治疗小儿上呼吸道感染具有独特疗效,且疗效显著,服药期间可正常学习和生活,疗程短,见效快,安全可靠,无毒副作用,能够达到标本兼治的目的,值得广泛推广应用。The invention provides a traditional Chinese medicine preparation for treating upper respiratory tract infection in children and a preparation method thereof; the selected medicinal materials of the Chinese medicine preparation of the invention are compatible, conform to the theory of traditional Chinese medicine and modern medicine, and have the functions of dispelling wind and relieving exterior syndrome, clearing away heat and promoting dampness, and moistening the lungs. The effect of relieving cough has a unique curative effect on the treatment of upper respiratory tract infection in children, and the curative effect is significant. During the period of taking the medicine, you can study and live normally. The course of treatment is short, the effect is quick, safe and reliable, and has no toxic and side effects. .

为实现上述目的,本发明的技术方案实施如下:To achieve the above object, the technical solution of the present invention is implemented as follows:

一种治疗小儿上呼吸道感染的中药制剂,制成所述中药制剂有效成分的原料组成及重量份数为:A traditional Chinese medicine preparation for treating upper respiratory tract infection in children, the composition and parts by weight of the active ingredients of the Chinese medicinal preparation are as follows:

制成所述中药制剂有效成分的原料组成及重量份数为:The raw material composition and the parts by weight of making described Chinese medicine preparation active ingredient are:

制成所述中药制剂有效成分的原料组成及重量份数为:The raw material composition and the parts by weight of making described Chinese medicine preparation active ingredient are:

制成所述中药制剂有效成分的原料组成及重量份数为:The raw material composition and the parts by weight of making described Chinese medicine preparation active ingredient are:

一种治疗小儿上呼吸道感染的中药制剂的制备方法,包括以下工艺步骤:A preparation method of a traditional Chinese medicine preparation for treating infantile upper respiratory tract infection, comprising the following process steps:

(1)将岩扫把、游草、乌榄、火绒草、柏子仁、梨皮和榧子洗净,放入容器内,加入8~10倍量的蒸馏水,浸泡5~6小时后,煮沸3~4小时,提取;再次加入6~8倍量蒸馏水,煮沸2~3小时,提取;最后,加入4~6倍量蒸馏水,加热煮沸1~2小时,提取;合并三次提取液,过滤,得滤液,备用;(1) Wash the rock broom, youcao, black olive, edelweiss, cypress kernels, pear skin and torreya, put them in a container, add 8 to 10 times the amount of distilled water, soak for 5 to 6 hours, and boil for 3 to 6 hours. 4 hours, extract; add 6-8 times the amount of distilled water again, boil for 2-3 hours, extract; finally, add 4-6 times the amount of distilled water, heat and boil for 1-2 hours, extract; combine the three extracts, filter to obtain the filtrate ,spare;

(2)将葛根、瓜子金和紫珠放入容器内,进行粉碎处理,研末,过180目细粉,备用;(2) Pueraria lobata root, melon seed gold and purple pearl are put into the container, pulverize, grind into powder, pass 180 mesh fine powder, set aside;

(3)将芦荟叶、莲藕和甘蔗洗净,切碎,放入容器内,绞汁,滤杂质,留汁液,备用;(3) Wash the aloe vera leaves, lotus root and sugar cane, chop them, put them in a container, twist the juice, filter out impurities, keep the juice, and set aside;

(4)将芸香草和万丈深洗净,浸入5倍量的80%的乙醇溶液浸泡1~2小时,加热提取3小时,回收乙醇,滤过,得滤液,浓缩为65℃下相对密度为1.12~1.16的稠膏,备用;(4) Deep wash Rutaceae and Wanzhang, soak in 5 times the amount of 80% ethanol solution for 1 to 2 hours, heat and extract for 3 hours, recover ethanol, filter, and obtain the filtrate, which is concentrated to a relative density of 1.12~1.16 thick paste, set aside;

(5)将槐花放入锅内,武火炒制至微黄,取出放凉,研末,过200目细粉,备用;(5) Put the Sophora japonica flower into the pot, fry it until it is slightly yellow, take it out and let it cool, grind it into powder, pass it into 200 mesh fine powder, and set aside;

(6)将上述步骤(1)~(5)所制得的滤液、细粉、汁液以及稠膏混合,制成胶囊,即得本发明所述的治疗小儿上呼吸道感染的中药制剂。(6) Mix the filtrate, fine powder, juice and thick ointment prepared in the above steps (1) to (5) to make capsules, and obtain the traditional Chinese medicine preparation for treating infantile upper respiratory tract infection according to the present invention.

本发明所用中药的药性如下:The property of medicine of Chinese medicine used in the present invention is as follows:

岩扫把:味苦,性寒;归肝、胃、大肠经。清热解毒,燥湿。主治湿热黄疸,湿热痢疾,小儿惊风,目赤肿痛,丹毒游风,鹅口疮,跌打损伤。《中国药植志》载:“全草:散寒除风,去目雾,消浮肿。治耳聋,身发黄。亦作健胃驱蛔药。”Rock broom: bitter in the mouth, cold in nature; return liver, stomach, large intestine meridian. Heat-clearing and toxic substances removing, damp drying. Cure mainly damp-heat jaundice, damp-heat dysentery, infantile convulsions, conjunctival congestion, swelling and pain, erysipelas traveling wind, thrush, bruises. "Chinese Medicine Plants" contains: "The whole plant: dispels cold and wind, removes eye fog, and reduces edema. It can treat deafness and yellow body. It can also be used as a medicine for invigorating the stomach and repelling roundworms."

葛根:甘辛,平;入脾、胃经。升阳解肌,透疹止泻,除烦止温。治伤寒、温热头痛项强,烦热消渴,泄泻,痢疾,癍疹不透,高血压,心绞痛,耳聋。《别录》载:“疗伤寒中风头痛,解肌,发表,出汗,开腠理。疗金疮,止痛,胁风痛。生根汁,疗消渴,伤寒壮热。”现代医学研究,葛根黄酮具有防癌抗癌和雌激素样作用,可促进女性丰胸、养颜,尤其对中年妇女和绝经期妇女养颜保健作用明显。Radix Puerariae: Ganxin, flat; enters spleen, stomach meridian. Shengyang relieves muscles, penetrates rash and relieves diarrhea, relieves restlessness and relieves temperature. Treat typhoid fever, warm and hot headache, strong neck, dysphoria and thirst, diarrhea, dysentery, impervious rash, high blood pressure, angina pectoris, and deafness. "Bie Lu" contains: "Treatment of typhoid fever, stroke, headache, muscle relief, release, sweating, opening interstitial veins. Treatment of golden sores, pain relief, hypochondriac pain. Root juice, treatment of thirst, typhoid and strong fever." Modern medical research, kudzu root Flavonoids have anti-cancer and estrogen-like effects, and can promote breast enlargement and beauty in women, especially for middle-aged women and menopausal women.

芦荟叶:味苦涩,性寒。泻火通经,杀虫解毒。治白浊,尿血,妇女经闭、带下,小儿惊痫、疳积,烫伤,痔疮,疥疮,痈肿。《南宁市药物志》载:“消疳热,杀虫积,通经,凉肝。治妇人经闭,小儿惊痫、疳积。生用外敷,治汤火伤和痄腮。”Aloe leaves: bitter in taste, cold in nature. Purging fire to stimulate the menstrual flow, killing parasites and detoxifying. Treat white turbidity, hematuria, women's amenorrhea, leukorrhea, children's epilepsy, malnutrition, burns, hemorrhoids, scabies, carbuncle. "Nanning City Drug Records" contains: "eliminate malnutrition fever, kill insect accumulation, stimulate menstrual flow, cool liver. Treat amenorrhea in women, epilepsy and malnutrition accumulation in children. Apply externally to treat soup burns and mumps."

瓜子金:味微辛,性微温。活血散瘀,祛痰镇咳,解毒止痛。用于咽炎,扁桃体炎,口腔炎,咳嗽,小儿肺炎,小儿疳积,泌尿系结石,乳腺炎,骨髓炎,外用治毒蛇咬伤,疔疮疖肿。《中国药植图鉴》载:“根为镇静、祛痰剂,能益智安神,散郁化痰,消赤肿。治支气管炎,肺炎,咳嗽多痰,惊悸,健忘痈疽疮肿,喉痹。”Guazijin: Slightly pungent in taste, slightly warm in nature. Promoting blood circulation and dispelling blood stasis, eliminating phlegm and relieving cough, detoxifying and relieving pain. For pharyngitis, tonsillitis, stomatitis, cough, infantile pneumonia, infantile malnutrition, urinary calculi, mastitis, osteomyelitis, topical treatment of venomous snake bites, boils and furuncles. "Chinese Medicine Plant Illustrated Book" contains: "The root is a sedative and expectorant, which can improve intelligence and calm the nerves, dissipate stagnation and phlegm, and reduce redness and swelling. Treat bronchitis, pneumonia, cough with phlegm, palpitations, forgetful carbuncle sores, and sore throat. .”

游草:味平,性辛。疏风解表,利湿,通络止痛。主治感冒,头痛身疼,疟疾,白带,下肢水肿,小便不利,痹痛麻木。《四川中药志》载:“能散寒解表,通经络。治疟疾,感冒头身疼痛。”Youcao: flat in taste, pungent in nature. Dispelling wind and relieving exterior syndrome, promoting dampness, dredging collaterals and relieving pain. Indications for colds, headache and body pain, malaria, leucorrhea, edema of the lower limbs, dysuria, arthralgia and numbness. "Sichuan Traditional Chinese Medicine" contains: "It can dispel cold, relieve the exterior, and dredge the meridians. It can treat malaria, cold head and body pain."

莲藕:味甘,性凉,主补中焦,养神,益气力。能清热生津,凉血止血,散瘀血。《中医》载:“养神,益气力。”现代医学研究证实,藕的营养价值很高,富含铁、钙等微量元素,植物蛋白质、维生素以及淀粉含量也很丰富,有明显的补益气血,增强人体免疫力作用。Lotus root: sweet in taste, cool in nature, mainly nourishing the middle burner, nourishing the mind, and benefiting energy. Can clear away heat and promote body fluid, cool blood to stop bleeding, loose blood stasis. "Traditional Chinese Medicine" contains: "rejuvenate the mind and strengthen energy." Modern medical research has confirmed that lotus root has high nutritional value, rich in trace elements such as iron and calcium, and rich in plant protein, vitamins and starch, which has obvious benefits of nourishing qi and blood. , Enhance human immunity.

芸香草:味辛、苦,性温。解表,利湿,平喘,止咳。治伤暑感冒,淋病,风湿筋骨酸痛,慢性气管炎。《昆明民间常用草药》载:“清热解毒解暑,芳香健胃。治咽喉哑痛,中暑,胃脘饱闷,疮毒溃烂。”Herb Rue: pungent, bitter, warm in nature. Resolving exterior syndrome, promoting dampness, relieving asthma, relieving cough. Cure summer cold, gonorrhea, rheumatism, muscle and bone pain, and chronic bronchitis. "Kunming Folk Commonly Used Herbs" contains: "clearing away heat, detoxifying and relieving heat, fragrant and invigorating the stomach. Cure sore throat, heatstroke, fullness in the stomach, and ulceration of sores."

紫珠:味苦、涩,性平。止血,散瘀,消炎。用于衄血,咯血,胃肠出血,子宫出血,上呼吸道感染,扁桃体炎,肺炎,支气管炎;外用治外伤出血,烧伤。《中国药植图鉴》载:“对食道静脉出血,肠胃溃疡出血,鼻出血,创伤出血,肺出血以及拔牙出血均有良效。”Zizhu: bitter, astringent, neutral in nature. Hemostasis, dissipating blood stasis, anti-inflammatory. For epistaxis, hemoptysis, gastrointestinal bleeding, uterine bleeding, upper respiratory tract infection, tonsillitis, pneumonia, bronchitis; external use for traumatic bleeding, burns. "Chinese Medicine Plant Illustrated Book" contains: "It has good effects on esophageal venous bleeding, gastrointestinal ulcer bleeding, epistaxis, trauma bleeding, lung bleeding and tooth extraction bleeding."

万丈深:味苦、微甘,性平。健脾消积,清热解毒,下乳。用于小儿疳积,Wanzhangshen: bitter, slightly sweet, flat in nature. Invigorating the spleen and eliminating stagnation, clearing away heat and detoxification, and inducing breast milk. For infantile malnutrition,

乳汁不足,支气管炎,肺炎,肝炎,白带,肠风下血,筋骨疼痛,跌打损伤,疮疖痈肿。《云南中草药选》载:“润肺止咳,清热解毒,消食理气,催乳。治支气管炎,肺炎,痈疽,小儿疳积,乳汁不足,结膜炎。”Insufficient milk, bronchitis, pneumonia, hepatitis, leucorrhea, intestinal wind bleeding, muscle and bone pain, bruises, sores, furuncles, and carbuncles. "Yunnan Chinese Herbal Medicine Selection" contains: "Moisturizing the lungs and relieving cough, clearing away heat and detoxification, eliminating food and regulating qi, promoting lactation. Treating bronchitis, pneumonia, carbuncle, malnutrition in children, insufficient milk, conjunctivitis."

乌榄:味酸、涩,性平;归脾、肺经。舒筋活络,祛风祛湿,清热解毒,消肿止痛。用于风湿腰腿痛,手足麻木,感冒,上呼吸道炎,肺炎,多发性疖肿。《岭南采药录》载:“火煅存性,止血化痰。少盐渍之,名榄豉,乳痈初起,煎水洗之可消。”Black Olive: sour in taste, astringent, neutral in nature; returns to the spleen and lung meridians. Relaxing tendons and activating collaterals, expelling wind and dampness, clearing heat and detoxification, reducing swelling and alleviating pain. For rheumatism low back pain, numb hands and feet, colds, upper respiratory tract inflammation, pneumonia, multiple boils. "Lingnan Caiyaolu" contains: "Fire calcining preserves properties, stops bleeding and resolves phlegm. It is less salty, and it is called olive soy. At the beginning of milk carbuncle, it can be decocted and washed with water to eliminate it."

槐花:味苦,性微寒;入肝、肺、心、大肠经。凉血止血,清肝明目。主治肠风便血,痔疮下血,血痢,尿血,血淋,崩漏,吐血,衄血,肝热头痛,目赤肿痛,痈肿疮疡。《本草正》载:“凉大肠,杀疳虫。治痈疽疮毒,阴疮湿痒,痔漏,解杨梅恶疮,下疳伏毒。”现代医学研究证实,槐花所含的芸香甙可增强毛细血管抵抗力,改善血管壁脆性,降低血压、抗水肿,对高血压有防止脑血管破裂的功效,此外还有抗炎作用。Sophora japonica: bitter in the mouth, slightly cold in nature; enters liver, lung, heart, large intestine meridians. Cooling blood to stop bleeding, clearing liver and improving eyesight. Indications for intestinal wind and blood in stool, hemorrhoids, bloody dysentery, hematuria, stranguria with blood, metrorrhagia, hematemesis, epistaxis, headache due to liver heat, conjunctival congestion and swelling pain, carbuncle and sore. "Materia Medica" contains: "Cool the large intestine, kill rickets. Treat carbuncle sores, vulva itching, hemorrhoids, relieve bayberry sores, and chancre poison." Modern medical research has confirmed that the rutin contained in Sophora japonica can Enhance capillary resistance, improve vascular wall fragility, lower blood pressure, resist edema, prevent cerebral blood vessel rupture for high blood pressure, and also have anti-inflammatory effects.

火绒草:味微苦,性寒。疏风清热,利尿止血。主治流行性感冒,急慢性肾炎,尿路感染,尿血,创伤出血。Edelweiss: taste slightly bitter, cold in nature. Dispelling wind and clearing away heat, inducing diuresis to stop bleeding. Indications for influenza, acute and chronic nephritis, urinary tract infection, hematuria, traumatic bleeding.

甘蔗:味甘、涩、性平,无毒。治下气和中,助脾气,利大肠,消痰止渴,除心胸烦热,解酒毒;还可治呕吐反胃,宽胸膈。现代医学研究表明,甘蔗中含有丰富的糖分、水分,此外,还含有对人体新陈代谢非常有益的各种维生素、脂肪、蛋白质、有机酸、钙、铁等物质。Sugarcane: sweet, astringent, mild in nature, non-toxic. Harmonize Qi, help temper, sharpen the large intestine, eliminate phlegm and quench thirst, remove heart and chest troubles and heat, relieve alcohol poisoning; it can also cure vomiting and nausea, and widen the chest and diaphragm. Modern medical research shows that sugarcane is rich in sugar and water. In addition, it also contains various vitamins, fats, proteins, organic acids, calcium, iron and other substances that are very beneficial to human metabolism.

柏子仁:味甘,性平;归心、肾、大肠经。养心安神,止汗,润肠。用于虚烦失眠,心悸怔忡,阴虚盗汗,肠燥便秘。《纲目》载:“养心气,润肾燥,益智宁神;烧沥治疥癣。”Boziren: sweet in taste, flat in nature; Guixin, kidney, and large intestine meridian. Nourish the heart and calm the nerves, stop sweating, moisten the intestines. For fatigue and insomnia, palpitations, night sweats due to yin deficiency, intestinal dryness and constipation. "Compendium" contains: "Nurture the heart, moisten the kidneys and dryness, improve intelligence and calm the mind; burn lek to treat scabies."

梨皮:味甘、涩,性凉,无毒;归肺、心、肾、大肠经。清心润肺,降火生津,解疮毒。主治暑热烦渴,肺燥咳嗽,吐血,痢疾,疥癣,发背,疔疮。《本草再新》载:“清心降火,滋肾益阴,主津止渴,除烦去湿。”Pear skin: sweet, astringent, cool in nature, non-toxic; returns to the lung, heart, kidney, and large intestine meridians. Clears away heart-fire and nourishes the lungs, reduces fire and promotes body fluid, relieves sores. Indications for summer heat and polydipsia, dryness of the lungs, cough, hematemesis, dysentery, scabies, hairy back, and furuncles. "Materia Medica Zaixin" contains: "Cleanses the heart and reduces fire, nourishes the kidneys and nourishes yin, governs body fluids and quenches thirst, eliminates annoyance and dampness."

榧子:味甘、涩,性平;归大肠、胃、肺经。杀虫消积,润燥通便。用于钩虫、蛔虫、绦虫病,虫积腹痛,小儿疳积,大便秘结。《本草再新》载:“治肺火,健脾土,补气化痰,止咳嗽,定呵喘,去瘀生新。”Torreya chinensis: sweet in the mouth, astringent, flat in nature; Return large intestine, stomach, lung meridian. Killing insects and eliminating stagnation, moistening dryness and laxative. For hookworms, roundworms, tapeworms, abdominal pain caused by worms, malnutrition in children, constipation. "Materia Medica Zaixin" contains: "cures lung fire, invigorates spleen soil, nourishes qi and resolves phlegm, relieves cough, calms asthma, removes blood stasis and promotes regeneration."

本发明与现有技术相比,具有以下有益效果:Compared with the prior art, the present invention has the following beneficial effects:

本发明中药制剂所选药材配伍相宜,符合中医药学和现代医药学理论,并具有疏风解表、清热利湿、润肺止咳之功效,对治疗小儿上呼吸道感染具有独特疗效,且疗效显著,服药期间可正常学习和生活,疗程短,见效快,安全可靠,无毒副作用,能够达到标本兼治的目的,值得广泛推广应用。The medicinal materials selected for the Chinese medicine preparation of the present invention are suitable in compatibility, conform to the theories of traditional Chinese medicine and modern medicine, and have the effects of dispelling wind and relieving exterior syndrome, clearing heat and promoting dampness, moistening lung and relieving cough, and have unique and remarkable curative effects on treating upper respiratory tract infection in children. During the period of taking the medicine, one can study and live normally, the course of treatment is short, the effect is quick, safe and reliable, without toxic and side effects, and the purpose of treating both symptoms and root causes can be achieved, and it is worthy of wide popularization and application.

具体实施方式Detailed ways

下面结合具体实施例对本发明做进一步阐述。The present invention will be further elaborated below in conjunction with specific embodiments.

实施例1Example 1

本发明中药制剂有效成分的原料组成及重量为:The raw material composition and the weight of Chinese medicine preparation active ingredient of the present invention are:

一种治疗小儿上呼吸道感染的中药制剂的制备方法,包括以下工艺步骤:A preparation method of a traditional Chinese medicine preparation for treating infantile upper respiratory tract infection, comprising the following process steps:

(1)将岩扫把、游草、乌榄、火绒草、柏子仁、梨皮和榧子洗净,放入容器内,加入8~10倍量的蒸馏水,浸泡5~6小时后,煮沸3~4小时,提取;再次加入6~8倍量蒸馏水,煮沸2~3小时,提取;最后,加入4~6倍量蒸馏水,加热煮沸1~2小时,提取;合并三次提取液,过滤,得滤液,备用;(1) Wash the rock broom, youcao, black olive, edelweiss, cypress kernels, pear skin and torreya, put them in a container, add 8 to 10 times the amount of distilled water, soak for 5 to 6 hours, and boil for 3 to 6 hours. 4 hours, extract; add 6-8 times the amount of distilled water again, boil for 2-3 hours, extract; finally, add 4-6 times the amount of distilled water, heat and boil for 1-2 hours, extract; combine the three extracts, filter to obtain the filtrate ,spare;

(2)将葛根、瓜子金和紫珠放入容器内,进行粉碎处理,研末,过180目细粉,备用;(2) Pueraria lobata root, melon seed gold and purple pearl are put into the container, pulverize, grind into powder, pass 180 mesh fine powder, set aside;

(3)将芦荟叶、莲藕和甘蔗洗净,切碎,放入容器内,绞汁,滤杂质,留汁液,备用;(3) Wash the aloe vera leaves, lotus root and sugar cane, chop them, put them in a container, twist the juice, filter out impurities, keep the juice, and set aside;

(4)将芸香草和万丈深洗净,浸入5倍量的80%的乙醇溶液浸泡1~2小时,加热提取3小时,回收乙醇,滤过,得滤液,浓缩为65℃下相对密度为1.12~1.16的稠膏,备用;(4) Deep wash Rutaceae and Wanzhang, soak in 5 times the amount of 80% ethanol solution for 1 to 2 hours, heat and extract for 3 hours, recover ethanol, filter, and obtain the filtrate, which is concentrated to a relative density of 1.12~1.16 thick paste, set aside;

(5)将槐花放入锅内,武火炒制至微黄,取出放凉,研末,过200目细粉,备用;(5) Put the Sophora japonica flower into the pot, fry it until it is slightly yellow, take it out and let it cool, grind it into powder, pass it into 200 mesh fine powder, and set aside;

(6)将上述步骤(1)~(5)所制得的滤液、细粉、汁液以及稠膏混合,制成胶囊,即得本发明所述的治疗小儿上呼吸道感染的中药制剂。(6) Mix the filtrate, fine powder, juice and thick ointment prepared in the above steps (1) to (5) to make capsules, and obtain the traditional Chinese medicine preparation for treating infantile upper respiratory tract infection according to the present invention.

用法用量:口服即可,每日2次,早晚各1次,每次1粒(每粒0.3g),饭后温开水送服或溶于水送服;2~6天即可痊愈,病情严重者遵医嘱酌增用量。Dosage: Take it orally, 2 times a day, 1 time in the morning and 1 time in the evening, 1 capsule each time (0.3g per capsule), take it with warm water or dissolve it in water after meals; it can be cured within 2 to 6 days, and the condition In severe cases, follow the doctor's advice to increase the dosage.

实施例2Example 2

本发明中药制剂有效成分的原料组成及重量为:The raw material composition and the weight of Chinese medicine preparation active ingredient of the present invention are:

本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。The preparation method of the traditional Chinese medicine preparation of the present embodiment is the same as the embodiment 1 in terms of process steps, usage and dosage.

实施例3Example 3

本发明中药制剂有效成分的原料组成及重量为:The raw material composition and the weight of Chinese medicine preparation active ingredient of the present invention are:

本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。The preparation method of the traditional Chinese medicine preparation of the present embodiment is the same as the embodiment 1 in terms of process steps, usage and dosage.

实施例4Example 4

本发明中药制剂有效成分的原料组成及重量为:The raw material composition and the weight of Chinese medicine preparation active ingredient of the present invention are:

本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。The preparation method of the traditional Chinese medicine preparation of the present embodiment is the same as the embodiment 1 in terms of process steps, usage and dosage.

实施例5Example 5

本发明中药制剂有效成分的原料组成及重量为:The raw material composition and the weight of Chinese medicine preparation active ingredient of the present invention are:

本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。The preparation method of the traditional Chinese medicine preparation of the present embodiment is the same as the embodiment 1 in terms of process steps, usage and dosage.

临床资料:clinical information:

1、病例选择:1. Case selection:

作为治疗小儿上呼吸道感染的中药制剂,选择确诊的小儿上呼吸道感染患者104例临床观察,病人随机分成治疗组和对照组两组,治疗组52例,其中男童26例,女童26例,年龄1~12岁,平均年龄6.5岁,平均病程1个月;对照组52例,其中男童26例,女童26例,年龄1~12岁,平均年龄6.5岁,平均病程1个月。As a traditional Chinese medicine preparation for the treatment of upper respiratory tract infection in children, 104 cases of confirmed upper respiratory tract infection in children were selected for clinical observation, and the patients were randomly divided into two groups: a treatment group and a control group, and the treatment group consisted of 52 cases, including 26 boys and 26 girls. 1 to 12 years old, with an average age of 6.5 years, and an average disease course of 1 month; 52 cases in the control group, including 26 boys and 26 girls, aged 1 to 12 years, with an average age of 6.5 years, and an average disease course of 1 month.

治疗组和对照组两组病例的病程、症状轻重程度基本一致,无显著差异,具有可比性。The course of disease and the severity of symptoms in the treatment group and the control group were basically the same without significant difference and comparable.

2、药物选择:2. Drug selection:

治疗组服用本发明中药制剂,口服即可,每日2次,早晚各1次,每次1粒(每粒0.3g),饭后温开水送服或溶于水送服;2~6天即可痊愈,病情严重者遵医嘱酌增用量。The treatment group takes the traditional Chinese medicine preparation of the present invention, and it can be taken orally, twice a day, once in the morning and once in the evening, 1 capsule (0.3g per capsule) each time, taken with warm water or dissolved in water after meals; 2-6 days It can be cured, and the dosage can be increased according to the doctor's advice in severe cases.

对照组服用小儿回春丸,嚼服,成人一次1.2~2.4克(按乳酸菌素计),一日3次;小儿一次0.4~0.8克(按乳酸菌素计),一日3次。The control group took Xiaoer Huichun Pills, chewed, 1.2-2.4 grams (calculated as lactobacillus) for adults, 3 times a day; 0.4-0.8 grams (calculated as lactobacillus), 3 times a day for children.

3、疗效判定:3. Judgment of curative effect:

(1)治愈:症状全部消失,各项指标恢复正常。(1) Cure: all the symptoms disappeared, and all the indicators returned to normal.

(2)显效:症状明显改善,各项指标有所好转。(2) Significantly effective: the symptoms were obviously improved, and all the indicators took a turn for the better.

(3)有效:症状有所改善,各项指标明显好转。(3) Effective: Symptoms are improved, and all indicators are obviously improved.

(4)无效:通过治疗后症状无减轻或加重。(4) Ineffective: no relief or aggravation of symptoms after treatment.

4、结果:4. Results:

选用本发明中药制剂的治疗组中,治愈30例,显效14例,有效7例,无效1例,治愈率57.7%,总有效率98.1%。In the treatment group using the traditional Chinese medicine preparation of the present invention, 30 cases were cured, 14 cases were markedly effective, 7 cases were effective, and 1 case was ineffective, the cure rate was 57.7%, and the total effective rate was 98.1%.

对照组中治愈20例,显效13例,有效8例,无效11例,治愈率16.7%,总有效率55.8%。In the control group, 20 cases were cured, 13 cases were markedly effective, 8 cases were effective, and 11 cases were ineffective. The cure rate was 16.7%, and the total effective rate was 55.8%.

以上结果显示,治疗组的治愈率和总有效率明显高于对照组。The above results showed that the cure rate and total effective rate of the treatment group were significantly higher than those of the control group.

以上结果显示,治疗组的治愈率和总有效率明显高于对照组。The above results showed that the cure rate and total effective rate of the treatment group were significantly higher than those of the control group.

典型病例举例:Typical case example:

1、蒋某,男,5岁,云南玉溪人。患者连续2天打喷嚏、咳嗽,发热,体温39.5℃,去医院检查发现患有小儿上呼吸道感染,经服用本发明中药制剂治疗,服用1天后,症状有所好转,体温有所降低,继续服用2天后,症状消失,体温恢复正常。1. Jiang, male, 5 years old, from Yuxi, Yunnan. The patient sneezed, coughed, had fever for 2 consecutive days, and had a body temperature of 39.5°C. He went to the hospital for examination and found that he had an upper respiratory tract infection in children. After taking the traditional Chinese medicine preparation of the present invention for treatment, after taking it for 1 day, the symptoms improved and the body temperature decreased. Continue to take it After 2 days, the symptoms disappeared and the body temperature returned to normal.

2、魏某,女,7岁,安徽蚌埠人。患者咽痛,伴有发热,体温39℃,检查发现咽及扁桃体表面有灰白色疱疹及表溃疡,周围环绕红晕,确诊为小儿上呼吸道感染,经服用本发明中药制剂治疗,服用2天后,症状有所好转,体温恢复正常,继续服用2天后,症状全部消失,身体恢复正常。2. Wei, female, 7 years old, from Bengbu, Anhui. The patient had a sore throat, accompanied by fever, with a body temperature of 39°C. The examination found that there were gray-white herpes and surface ulcers on the surface of the pharynx and tonsils, surrounded by blush, and was diagnosed as an upper respiratory tract infection in children. After taking the traditional Chinese medicine preparation of the present invention for treatment, after taking 2 days, the symptoms were as follows: The body took a turn for the better, and the body temperature returned to normal. After continuing to take it for 2 days, the symptoms all disappeared, and the body returned to normal.

3、叶某,男,3岁,吉林辽源人。患者感冒、并伴有腹泻,去医院就诊,被确诊为小儿上呼吸道感染,经医生建议服用本发明中药制剂治疗,服用1天后,症状明显好转,服用2个疗程后,症状消失,痊愈。3. Yemou, male, 3 years old, from Liaoyuan, Jilin. The patient catches a cold and is accompanied by diarrhea, goes to the hospital for treatment, and is diagnosed as an upper respiratory tract infection in children. The doctor advises to take the Chinese medicine preparation of the present invention for treatment. After taking 1 day, the symptoms obviously take a turn for the better. After taking 2 courses of treatment, the symptoms disappear and recover.

4、薛某,男,8岁,湖南湘潭人。患者2天前受凉后发热,体温40.3℃,伴流涕质清、鼻塞喷嚏,服用过药物治疗,效果一般。诊见高热、流涕黄稠、咳嗽痰少,舌红苔薄黄,脉浮数。查体:t39.5℃,咽红,扁桃体肿大i度,血常规无异常,诊断为小儿上呼吸道感染,服用本发明中药制剂治疗,服用2天后,体温有所降低,咳嗽减轻,继续服用3天后,上述症状全部消失,体温恢复正常,痊愈。4. Xue, male, 8 years old, from Xiangtan, Hunan. The patient had a fever after catching a cold 2 days ago, with a body temperature of 40.3°C, accompanied by runny nose, nasal congestion and sneezing. He had taken medication, but the effect was mediocre. Examine and see high fever, runny nose yellow and thick, cough with little sputum, red tongue with thin yellow coating, floating and rapid pulse. Have a medical check-up: t39.5 ℃, pharynx is red, tonsil enlargement I degree, blood routine is normal, is diagnosed as infantile upper respiratory tract infection, takes Chinese medicine preparation of the present invention for treatment, after taking 2 days, body temperature reduces to some extent, and cough alleviates, and continues to take After 3 days, above-mentioned symptom all disappears, and body temperature returns to normal, and recovery from illness.

5、阎某,女,4岁,河南平顶山人。患者流涕、低热1天,咳嗽,涕泪交加。咽腔轻微红肿,两侧扁桃体肿大,轻微充血,干咳频繁,两肺呼吸音清,舌质红,苔薄黄,脉浮数兼滑实,诊断为小儿上呼吸道感染,服用本发明中药制剂治疗服用2天后,症状明显改善,服用3个天后,症状全部消失,痊愈。5. Yan, female, 4 years old, from Pingdingshan, Henan. The patient had runny nose, low fever for 1 day, cough, tears and tears. Pharyngeal cavity is slightly red and swollen, tonsils on both sides are swollen, slightly congested, dry cough is frequent, both lungs have clear breath sounds, red tongue, thin yellow coating, floating and slippery pulse. It is diagnosed as upper respiratory tract infection in children. Take the traditional Chinese medicine preparation of the present invention. After taking 2 days for the treatment, the symptoms were obviously improved, and after 3 days, the symptoms all disappeared and recovered.

6、夏某,女,10岁,甘肃张掖人。患者发热1天,温度39.3℃,咳嗽,痰多,色白质稀,喉中痰鸣,纳食尚可,夜寐不安,舌淡红,苔白腻,诊断为小儿上呼吸道感染,服用本发明中药制剂治疗,服用1天后,症状有所缓解,夜寐安和,体温有所好转,继续服用3天后,症状消失,体温恢复正常,痊愈。6. Xia, female, 10 years old, is from Zhangye, Gansu. The patient had a fever for 1 day, with a temperature of 39.3°C, cough, phlegm, thin white matter, phlegm in the throat, acceptable appetite, uneasy sleep at night, pale red tongue, white and greasy fur. He was diagnosed as an upper respiratory tract infection in children. He took the present invention Chinese medicine preparation treatment, after taking 1 day, symptom alleviates to some extent, night sleeps peacefully, body temperature takes a turn for the better to some extent, after continuing to take 3 days, symptom disappears, and body temperature returns to normal, recovery from illness.

Claims (5)

1. treat a Chinese medicine preparation for infant upper respiratory tract infection, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Herba Thalictri Ichangensis 40 ~ 63 parts of Radix Puerariaes 37 ~ 61 parts of Folium Aloes 36 ~ 60 parts of Herba Polygalae Japonicae 34 ~ 58 parts
Herba leerisae hexandrae 32 ~ 56 parts of Rhizoma Nelumbiniss 30 ~ 54 parts of Herba Cymbopogoniss 29 ~ 53 portions of Folium Callicarpae Formosanaes 28 ~ 52 parts
Radix Crepidis Ligneae 25 ~ 49 portions of Fructus Canarii Pimelaes 24 ~ 48 parts of Flos Sophoraes 21 ~ 45 parts of Leontopodium leontopodioides (Willd.) Beauv. 19 ~ 43 parts
Caulis Sacchari sinensis 17 ~ 41 parts of Semen Platycladi 15 ~ 38 parts of Pericarpium Pyri 15 ~ 34 portions of Semen Torreyaes 12 ~ 30 parts.
2. a kind of Chinese medicine preparation for the treatment of infant upper respiratory tract infection according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Herba Thalictri Ichangensis 43 ~ 59 parts of Radix Puerariaes 41 ~ 57 parts of Folium Aloes 40 ~ 56 parts of Herba Polygalae Japonicae 38 ~ 54 parts
Herba leerisae hexandrae 36 ~ 52 parts of Rhizoma Nelumbiniss 34 ~ 50 parts of Herba Cymbopogoniss 33 ~ 49 portions of Folium Callicarpae Formosanaes 32 ~ 48 parts
Radix Crepidis Ligneae 29 ~ 45 portions of Fructus Canarii Pimelaes 28 ~ 44 parts of Flos Sophoraes 25 ~ 41 parts of Leontopodium leontopodioides (Willd.) Beauv. 23 ~ 39 parts
Caulis Sacchari sinensis 21 ~ 37 parts of Semen Platycladi 19 ~ 34 parts of Pericarpium Pyri 18 ~ 30 portions of Semen Torreyaes 15 ~ 27 parts.
3. a kind of Chinese medicine preparation for the treatment of infant upper respiratory tract infection according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Herba Thalictri Ichangensis 47 ~ 55 parts of Radix Puerariaes 45 ~ 53 parts of Folium Aloes 44 ~ 52 parts of Herba Polygalae Japonicae 42 ~ 50 parts
Herba leerisae hexandrae 40 ~ 48 parts of Rhizoma Nelumbiniss 38 ~ 46 parts of Herba Cymbopogoniss 37 ~ 45 portions of Folium Callicarpae Formosanaes 36 ~ 44 parts
Radix Crepidis Ligneae 33 ~ 41 portions of Fructus Canarii Pimelaes 32 ~ 40 parts of Flos Sophoraes 29 ~ 37 parts of Leontopodium leontopodioides (Willd.) Beauv. 27 ~ 35 parts
Caulis Sacchari sinensis 25 ~ 33 parts of Semen Platycladi 22 ~ 30 parts of Pericarpium Pyri 21 ~ 27 portions of Semen Torreyaes 18 ~ 24 parts.
4. a kind of Chinese medicine preparation for the treatment of infant upper respiratory tract infection according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Herba Thalictri Ichangensis 51 parts of Radix Puerariaes 49 parts of Folium Aloes 48 parts of Herba Polygalae Japonicae 46 parts
Herba leerisae hexandrae 44 parts of Rhizoma Nelumbiniss 42 parts of Herba Cymbopogoniss 41 portions of Folium Callicarpae Formosanaes 40 parts
Radix Crepidis Ligneae 37 portions of Fructus Canarii Pimelaes 36 parts of Flos Sophoraes 33 parts of Leontopodium leontopodioides (Willd.) Beauv. 31 parts
Caulis Sacchari sinensis 29 parts of Semen Platycladi 26 parts of Pericarpium Pyri 24 portions of Semen Torreyaes 21 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for the Chinese medicine preparation of infant upper respiratory tract infection, it is characterized in that: comprise following processing step:
(1) Herba Thalictri Ichangensis, Herba leerisae hexandrae, Fructus Canarii Pimelae, Leontopodium leontopodioides (Willd.) Beauv., Semen Platycladi, Pericarpium Pyri and Semen Torreyae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) Radix Puerariae, Herba Polygalae Japonicae and Folium Callicarpae Formosanae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(3) Folium Aloe, Rhizoma Nelumbinis and Caulis Sacchari sinensis are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice, for subsequent use;
(4) Herba Cymbopogonis and Radix Crepidis Ligneae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) Flos Sophorae is put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 200 order fine powders, for subsequent use;
(6) by the filtrate obtained by above-mentioned steps (1) ~ (5), fine powder, juice and thick paste mixing, make capsule, obtain the Chinese medicine preparation of described treatment infant upper respiratory tract infection.
CN201410797518.2A 2014-12-19 2014-12-19 Traditional Chinese medicinal preparation for treating infantile upper respiratory infection and preparation method of traditional Chinese medicinal preparation Expired - Fee Related CN104435860B (en)

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