CN105878635A - Traditional Chinese medicinal composition with efficacies of relaxing muscles and stimulating blood circulation and preparation method of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition with efficacies of relaxing muscles and stimulating blood circulation and preparation method of traditional Chinese medicinal composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition with the efficacies of relaxing muscles and stimulating blood circulation and a preparation method of the traditional Chinese medicinal composition, belonging to the field of modernization of the Chinese traditional medicine. The traditional Chinese medicinal composition is prepared from the following medicinal materials in parts by weight: 40 parts of gypsum, 20 parts of realgar, 40 parts of prepared kusnezoff monkshood root, 40 parts of radix aconiti preparata, 20 parts of processed rhizoma typhonii, 20 parts of licorice root, 60 parts of rhizoma pinelliae, 80 parts of radix angelica sinensis, 32 parts of cassia twig, 80 parts of radix dipsaci, 80 parts of radices paeoniae alba, 80 parts of rhizoma ligustici wallichii, 40 parts of radix angelicae, 80 parts of divaricate saposhnikovia root, 24 parts of arisaema cum bile, 80 parts of bombyx batryticatus, and 40 parts of earthworm. According to the research result on the physicochemical properties and pharmacological effects of the ingredients in the medicinal materials, the preparation method of the traditional Chinese medicinal composition containing the reasonable and stable medicinal materials is obtained. With the adoption of the technical scheme, the prepared medicine is stable and controllable in quality, the curative effects of the prepared medicine are obviously improved compared with those of the existing compositions sold in the market, the taking dosage of the patient is reduced, and therefore, the traditional Chinese medicinal composition has obvious economic and social benefits.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of relaxing muscles and tendons to promote blood circulation and preparation method thereof, belong to the modernization of Chinese medicine
Field.
Background technology
Rheumatism is one group and invades joint, skeleton, muscle, blood vessel and relevant soft tissue or connective tissue and be
Main disease, wherein majority is autoimmune disease.Morbidity is much more hidden and slow, and the course of disease is longer,
And there is genetic predisposition mostly.
Rheumatism is a kind of based on muscle with the disease of arthralgia, and its appearance makes patient's pain be not intended to
Raw.The blood circulation that rheumatism causes mainly due to wind and cold is obstructed, cause include flesh, ligament,
Synovial bursa, the bad disease caused of nutrition supply of fascia.Arthropathy in addition to having pain still with swelling and
Moving obstacle, in outbreak with the chronic course of disease alleviated alternately, some patients and may occur in which to disable and interior in joint
Dirty nonfunction.
" rheumatism " a kind of traditional concept, the traditional Chinese medical science is considered due to the exopathogen such as wind, cold, wet, heat
Invasion and attack human body, impatency passages through which vital energy circulates causes, wind-engaging, cold and cause disease.Human feeling's wind, cold, wet is evil
And dedicate one's life to pain or heavy sensation of the body, arthralgia, the disease of joint stuffiness." Medical Treasures of the Golden Chamber convulsion damp disease arteries and veins is demonstrate,proved
Control ": " patient's general aching on the body, heating, late afternoon play person, name rheumatism.This disease is hindered in exposure to wind when sweating,
Or caused by pathogenic cold attacking for a long time also." rheumatism, floating pulse heavy sensation of the body, perspiration and aversion to wind person, Tetrandra and Astragalus Decoction master it." " wind
Wetting phase is fought, acute pain in the joints dragging pain, must not bend and stretch, and near then pain is acute, sweating and shortness of breath, and dysuria is disliked
Wind no desire to take off clothes, or slight swelling of the body person, Radix Glycyrrhizae et Radix Aconiti Lateralis Preparata Decoction master it.”
The disease that rheumatism includes is a lot of, and it refers to that a big class current cause and onset of disease mechanism is not yet studied clearly
Chu, to damage synovial membrane, cartilage, BJM, ligament etc., and can invade multiple system
Systemic disease.
Chasing after wind sheet is the Chinese medicine that a kind of relaxing muscles and tendons to promote blood circulation sold in the market dissipates air slaking expectorant.Soft for muscles and bones
Weak, numb hand and foot, lumbar and back pain, walking hardship by the disease caused by rheumatism.
The prescription and the preparation method that chase after wind sheet be: Gypsum Fibrosum 40g, Realgar 20g, Radix Aconiti Kusnezoffii Preparata 40g, Radix Aconiti Preparata 40g,
Rhizoma Typhonii (system) 20g, Radix Glycyrrhizae 20g, Rhizoma Pinelliae 60g, Radix Angelicae Sinensis 80g, Ramulus Cinnamomi 32g, Radix Dipsaci 80g,
Radix Paeoniae Alba 80g, Rhizoma Chuanxiong 80g, Radix Angelicae Dahuricae 40g, Radix Saposhnikoviae 80g, Arisaema Cum Bile 24g, Bombyx Batryticatus 80g, Pheretima 40g,
Herba Schizonepetae oil 0.2ml.Gypsum Fibrosum powder is broken into fine powder, and Realgar water flies or be ground into impalpable powder, and Herba Schizonepetae oil is with suitable
Amount ethanol dissolves, standby.Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparata, Rhizoma Typhonii (crushing), Radix Glycyrrhizae.Boiling secondary,
3 hours for the first time, 2 hours for the second time, after half summer grade cold water soak to the saturating heart, add Rhizoma Zingiberis 5g decocting in water two
Secondary, 3 hours for the first time, 2 hours for the second time, merge above aqueous extract, filter, filtrate is condensed into
The clear paste (50-60 DEG C) of relative density 1.20～1.30.Radix Angelicae Sinensis ethanol 3 times amount reflux, extract, 8
Hour, then with 60% ethanol 3 times amount reflux, extract, secondary, 4 hours for the first time, use 2 times amount for the second time
Ethanol extraction 2 hours, Ramulus Cinnamomi, Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Arisaema Cum Bile 60% second
Alcohol reflux extracts three times；Bombyx Batryticatus, Pheretima 25% alcohol reflux three times, the time is for the first time 6
Hour, 4 hours for the second time, 2 hours for the third time；Merge above ethanol extract, filter, reclaim second
Alcohol is condensed into cream, carries condensed cream with above-mentioned water and merges, and adds Gypsum Fibrosum, Realgar fine powder and auxiliary materials and mixing, system
Become granule, be dried and let cool, be blended into Herba Schizonepetae oil alcoholic solution, mixing, it is pressed into 830, to obtain final product.
Summary of the invention
First technical problem that the invention solves the problems that is to provide the Chinese medicine composition of a kind of relaxing muscles and tendons to promote blood circulation.
Another technical problem that the invention solves the problems that is to provide the preparation method of above-mentioned Chinese medicine composition.
For achieving the above object, the present invention is by the following technical solutions；
A kind of Chinese medicine composition of relaxing muscles and tendons to promote blood circulation, its active component is made up of the raw material of following parts by weight:
40 parts of Gypsum Fibrosum, Realgar 20 parts, Radix Aconiti Kusnezoffii Preparata 40 parts, Radix Aconiti Preparata 40 parts, Rhizoma Typhonii (system) 20
Part, 20 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 60 parts, Radix Angelicae Sinensis 80 parts, Ramulus Cinnamomi 32 parts, Radix Dipsaci 80 parts, the Radix Paeoniae Alba 80
Part, Rhizoma Chuanxiong 80 parts, the Radix Angelicae Dahuricae 40 parts, Radix Saposhnikoviae 80 parts, Arisaema Cum Bile 24 parts, Bombyx Batryticatus 80 parts,
Dragon 40 parts.
Described active component uses following method to prepare:
1, each raw material is weighed by proportioning raw materials；Gypsum Fibrosum powder is broken into fine powder, and Realgar water flies or is ground into superfine
Powder, standby.Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparata, Rhizoma Typhonii (crushing), Radix Glycyrrhizae.Boiling secondary, for the first time
3 hours, 2 hours for the second time, after half summer grade cold water soak to the saturating heart, add Rhizoma Zingiberis 5g decocting in water secondary, first
Secondary 3 hours, 2 hours for the second time, merging above aqueous extract, filter, filtrate is condensed into relative density
The clear paste (50-60 DEG C) of 1.20～1.30.Radix Angelicae Sinensis ethanol 3 times amount reflux, extract, 8 hours, then use
60% ethanol 3 times amount reflux, extract, secondary, 4 hours for the first time, for the second time with 2 times amount ethanol extractions 2
Hour, Ramulus Cinnamomi, Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Arisaema Cum Bile 60% alcohol reflux
Three times；Bombyx Batryticatus, Pheretima 25% alcohol reflux three times, the time is 6 hours for the first time, and second
Secondary 4 hours, 2 hours for the third time；Merge above ethanol extract, filter, reclaim ethanol and be condensed into cream,
Carry condensed cream with above-mentioned water to merge, add Gypsum Fibrosum, Realgar fine powder and auxiliary materials and mixing, make granule, be dried
Let cool, mixing, obtain dried object A.
2, each raw material is weighed by proportioning raw materials；Gypsum Fibrosum powder is broken into fine powder, and Realgar water flies or is ground into the thinnest
Powder, standby.Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparata, Rhizoma Typhonii (crushing), Radix Glycyrrhizae boiling secondary, for the first time
Adding water by 10 times of medical material weight, decoct 3 hours, second time adds water by 8 times of medical material weight, decocts
Boil 2 hours, after half summer grade cold water soak to the saturating heart, add Rhizoma Zingiberis 2.5kg decocting in water secondary, press medical material for the first time
10 times of weight add water, and decoct 3 hours, and second time adds water by 8 times of medical material weight, decoct 2 little
Time, merging above aqueous extract, filter, filtrate is concentrated into relative density 1.20-1.30 (55 DEG C).
Radix Angelicae Sinensis ethanol 3 times amount reflux, extract, 8 hours, then by 60% ethanol 3 times amount reflux, extract, 4 hours,
Third time 2 times amount 60% ethanol extraction 2 hours；Ramulus Cinnamomi, Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, anti-
Wind, Arisaema Cum Bile 60% alcohol reflux three times, presses 3 extraordinarily 60% ethanol of medical material weight for the first time,
Reflux, extract, 6 hours, second time presses 3 extraordinarily 60% ethanol of medical material weight, reflux, extract, 4 hours,
Third time presses 2 extraordinarily 60% ethanol of medical material weight, reflux, extract, 2 hours；Bombyx Batryticatus, Pheretima are with 25%
Alcohol reflux three times, presses for the first time 3 extraordinarily 25% ethanol of medical material weight, reflux, extract, 6 hours,
Second time presses 3 extraordinarily 25% ethanol of medical material weight, reflux, extract, 4 hours, and third time presses medical material weight
2 extraordinarily 25% ethanol, reflux, extract, 2 hours；Merge above ethanol extract, filter, reclaim second
Alcohol, is concentrated into relative density 1.20-1.30 (55 DEG C).Water extracting liquid and alcohol extraction concentrated solution are merged,
Add Gypsum Fibrosum, Realgar fine powder and the auxiliary materials and mixing such as starch, dextrin, make granule, be dried and let cool, mixing,
Obtain dried object A.
Described pharmaceutical composition is possibly together with the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from starch, microcrystalline Cellulose, sucrose, aspartame, paste
Essence, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium, crospolyvinylpyrrolidone,
Any one in magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite
Plant or several.
The dosage form of described Chinese medicine composition is peroral dosage form, include but not limited to pill, tablet, capsule or
Oral liquid.The selection of dosage form and the consumption of adjuvant belong to prior art.
A kind of preparation method of the Chinese medicine composition of relaxing muscles and tendons to promote blood circulation:
Weigh 40 parts of Gypsum Fibrosum, Realgar 20 parts, Radix Aconiti Kusnezoffii Preparata 40 parts, Radix Aconiti Preparata 40 parts, Rhizoma Typhonii (system)
20 parts, 20 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 60 parts, Radix Angelicae Sinensis 80 parts, Ramulus Cinnamomi 32 parts, Radix Dipsaci 80 parts, white
Chinese herbaceous peony 80 parts, Rhizoma Chuanxiong 80 parts, the Radix Angelicae Dahuricae 40 parts, Radix Saposhnikoviae 80 parts, Arisaema Cum Bile 24 parts, Bombyx Batryticatus 80
Part, Pheretima 40 parts.Gypsum Fibrosum powder is broken into fine powder, and Realgar water flies or be ground into impalpable powder, standby.System grass
Crow, Radix Aconiti Preparata, Rhizoma Typhonii (crushing), Radix Glycyrrhizae.Boiling secondary, 3 hours for the first time, for the second time
2 hours, after half summer grade cold water soak to the saturating heart, add Rhizoma Zingiberis 5g decocting in water secondary, 3 hours for the first time, second
Secondary 2 hours, merging above aqueous extract, filter, filtrate is condensed into relative density 1.20～1.30
Clear paste (50-60 DEG C).Radix Angelicae Sinensis ethanol 3 times amount reflux, extract, 8 hours, then with 60% ethanol 3
Times amount reflux, extract, secondary, 4 hours for the first time, second time 2 times amount ethanol extraction 2 hours, Ramulus Cinnamomi,
Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Arisaema Cum Bile 60% alcohol reflux three times；Bombyx Batryticatus,
Pheretima 25% alcohol reflux three times, the time is 6 hours for the first time, 4 hours for the second time, the
Three times 2 hours；Merge above ethanol extract, filter, reclaim ethanol and be condensed into cream, carry with above-mentioned water
Condensed cream merges, and adds Gypsum Fibrosum, Realgar fine powder and auxiliary materials and mixing, makes granule, is dried and lets cool, mixing,
Obtain dried object A.
Preferably preparation method is: weigh each raw material by proportioning raw materials；Gypsum Fibrosum powder is broken into fine powder, Realgar water
Fly or be ground into fine powder, standby.Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparata, Rhizoma Typhonii (crushing), Radix Glycyrrhizae add decocting
Boiling secondary, add water by 10 times of medical material weight for the first time, decoct 3 hours, second time presses medical material weight
8 times add water, decoct 2 hours, after half summer grade cold water soak to the saturating heart, add Rhizoma Zingiberis 2.5kg decocting in water secondary,
Add water by 10 times of medical material weight for the first time, decocts 3 hours, press the 8 of medical material weight for the second time extraordinarily
Water, decocts 2 hours, merges above aqueous extract, filters, and filtrate is concentrated into relative density 1.20-1.30
(55℃).Radix Angelicae Sinensis ethanol 3 times amount reflux, extract, 8 hours, then carry with 60% ethanol 3 times amount backflow
Take 4 hours, third time 2 times amount 60% ethanol extraction 2 hours；Ramulus Cinnamomi, Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Chuanxiong,
The Radix Angelicae Dahuricae, Radix Saposhnikoviae, Arisaema Cum Bile 60% alcohol reflux three times, press the 3 of medical material weight extraordinarily for the first time
60% ethanol, reflux, extract, 6 hours, second time presses 3 extraordinarily 60% ethanol of medical material weight, reflux, extract,
4 hours, third time pressed 2 extraordinarily 60% ethanol of medical material weight, reflux, extract, 2 hours；Bombyx Batryticatus,
Dragon 25% alcohol reflux three times, first time presses 3 extraordinarily 25% ethanol of medical material weight, and backflow carries
Taking 6 hours, second time presses 3 extraordinarily 25% ethanol of medical material weight, reflux, extract, 4 hours, for the third time
By 2 extraordinarily 25% ethanol of medical material weight, reflux, extract, 2 hours；Merge above ethanol extract, filter
Cross, reclaim ethanol, be concentrated into relative density 1.20-1.30 (55 DEG C).By water extracting liquid and alcohol extraction
Concentrated solution merges, and adds Gypsum Fibrosum, Realgar fine powder and the auxiliary materials and mixing such as starch, dextrin, makes granule, dry
Dry let cool, mixing, obtain dried object A.
The preparation of the Chinese medicine composition of a kind of relaxing muscles and tendons to promote blood circulation, said preparation adds with above-mentioned active constituents of medicine and is used as medicine
The acceptable adjuvant of agent, makes the acceptable dosage form of pharmaceutics.Utilize the Chinese medicine composition that the present invention obtains
When the active component of thing prepares the various dosage form of required medicine, can be according to the conventional production of art of pharmacy
Prepared by method.As mixed with one or more carriers by this active component, then make corresponding dosage form.
The invention have the advantage that the present invention uses theory of Chinese medical science to analyze prescription composition, contained by each flavour of a drug
The physicochemical property of composition and pharmacological action, research has obtained the preparation method of reasonable, stable active component.
Use technical scheme, on duty go out stable and controllable for quality, curative effect compared with the existing commercial dosage forms
Significantly improve, patient's taking dose reduce pharmaceutical preparation, there is significant economic and social benefit.
Describe technical solution of the present invention by the following examples in detail, do not limit the enforcement of the present invention with this
Scope.
Detailed description of the invention
Embodiment 1: prepare Chinese medicine extract
One, prescription: Gypsum Fibrosum 40g, Realgar 20g, Radix Aconiti Kusnezoffii Preparata 40g, Radix Aconiti Preparata 40g, Rhizoma Typhonii (system)
20g, Radix Glycyrrhizae 20g, Rhizoma Pinelliae 60g, Radix Angelicae Sinensis 80g, Ramulus Cinnamomi 32g, Radix Dipsaci 80g, Radix Paeoniae Alba 80g,
Rhizoma Chuanxiong 80g, Radix Angelicae Dahuricae 40g, Radix Saposhnikoviae 80g, Arisaema Cum Bile 24g, Bombyx Batryticatus 80g, Pheretima 40g.
Two, preparation method:
Gypsum Fibrosum powder is broken into fine powder, and Realgar water flies or be ground into fine powder, standby.Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparata,
Rhizoma Typhonii (crushing), Radix Glycyrrhizae boiling secondary, add water by 10 times of medical material weight for the first time, decocts
Boiling 3 hours, second time adds water by 8 times of medical material weight, decocts 2 hours, and half summer grade cold water soak is extremely
Thoroughly add Rhizoma Zingiberis 2.5kg decocting in water secondary after the heart, add water by 10 times of medical material weight for the first time, decoct 3 little
Time, second time adds water by 8 times of medical material weight, decocts 2 hours, merges above aqueous extract, filters,
Filtrate is concentrated into relative density 1.20-1.30 (55 DEG C).Radix Angelicae Sinensis ethanol 3 times amount reflux, extract, 8 is little
Time, then by 60% ethanol 3 times amount reflux, extract, 4 hours, third time is with 2 times amount 60% ethanol extractions 2
Hour；Ramulus Cinnamomi, Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Arisaema Cum Bile 60% alcohol reflux
Three times, pressing 3 extraordinarily 60% ethanol of medical material weight, reflux, extract, 6 hours for the first time, second time presses medicine
The 3 of material weight extraordinarily 60% ethanol, reflux, extract, 4 hours, third time presses the 2 extraordinarily 60% of medical material weight
Ethanol, reflux, extract, 2 hours；Bombyx Batryticatus, Pheretima 25% alcohol reflux three times, press medicine for the first time
The 3 of material weight extraordinarily 25% ethanol, reflux, extract, 6 hours, second time presses the 3 extraordinarily 25% of medical material weight
Ethanol, reflux, extract, 4 hours, third time presses 2 extraordinarily 25% ethanol of medical material weight, reflux, extract, 2
Hour；Merge above ethanol extract, filter, reclaim ethanol, be concentrated into relative density 1.20-1.30
(55℃).Water extracting liquid and alcohol extraction concentrated solution are merged, addition Gypsum Fibrosum, Realgar fine powder and starch,
The auxiliary materials and mixing such as dextrin, make granule, are dried and let cool, and mixing obtains dried object A and amounts to 498g.
Embodiment 2: prepare Chinese medicine extract
One, prescription: Gypsum Fibrosum 20kg, Realgar 10kg, Radix Aconiti Kusnezoffii Preparata 20kg, Radix Aconiti Preparata 20kg, the most attached
Son (system) 10kg, Radix Glycyrrhizae 10kg, Rhizoma Pinelliae 30kg, Radix Angelicae Sinensis 40kg, Ramulus Cinnamomi 16kg, Radix Dipsaci 40kg,
Radix Paeoniae Alba 40kg, Rhizoma Chuanxiong 40kg, Radix Angelicae Dahuricae 20kg, Radix Saposhnikoviae 40kg, Arisaema Cum Bile 12kg, Bombyx Batryticatus 40kg,
Pheretima 20kg.
Two, preparation method:
Gypsum Fibrosum powder is broken into fine powder, and Realgar water flies or be ground into fine powder, standby.Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparata,
Rhizoma Typhonii (crushing), Radix Glycyrrhizae boiling secondary, add water by 10 times of medical material weight for the first time, decocts
Boiling 3 hours, second time adds water by 8 times of medical material weight, decocts 2 hours, and half summer grade cold water soak is extremely
Thoroughly add Rhizoma Zingiberis 2.5kg decocting in water secondary after the heart, add water by 10 times of medical material weight for the first time, decoct 3 little
Time, second time adds water by 8 times of medical material weight, decocts 2 hours, merges above aqueous extract, filters,
Filtrate is concentrated into relative density 1.20-1.30 (55 DEG C).Radix Angelicae Sinensis ethanol 3 times amount reflux, extract, 8 is little
Time, then by 60% ethanol 3 times amount reflux, extract, 4 hours, third time is with 2 times amount 60% ethanol extractions 2
Hour；Ramulus Cinnamomi, Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Arisaema Cum Bile 60% alcohol reflux
Three times, pressing 3 extraordinarily 60% ethanol of medical material weight, reflux, extract, 6 hours for the first time, second time presses medicine
The 3 of material weight extraordinarily 60% ethanol, reflux, extract, 4 hours, third time presses the 2 extraordinarily 60% of medical material weight
Ethanol, reflux, extract, 2 hours；Bombyx Batryticatus, Pheretima 25% alcohol reflux three times, press medicine for the first time
The 3 of material weight extraordinarily 25% ethanol, reflux, extract, 6 hours, second time presses the 3 extraordinarily 25% of medical material weight
Ethanol, reflux, extract, 4 hours, third time presses 2 extraordinarily 25% ethanol of medical material weight, reflux, extract, 2
Hour；Merge above ethanol extract, filter, reclaim ethanol, be concentrated into relative density 1.20-1.30
(55℃).Water extracting liquid and alcohol extraction concentrated solution are merged, addition Gypsum Fibrosum, Realgar fine powder and starch,
The auxiliary materials and mixing such as dextrin, make granule, are dried and let cool, and mixing obtains dried object A and amounts to 249kg.
Embodiment 3: prepare tablet
The active component 100g that embodiment 1 obtains, adds microcrystalline Cellulose 40g, cross-linked pvp 7g, tabletting,
Obtain tablet, every tablet weight 0.6g.
Embodiment 4: prepare capsule
The active component 1000g that embodiment 2 obtains, adds starch 250g, encapsulating capsule, obtains capsule, often
Grain weight 0.50g.
Embodiment 5: zoopery
One, materials and methods:
Dimethylbenzene, Guangzhou Chemical Reagent Factory product.
Aspirin enteric-coated clothing, Liaohe Pharmaceutical Factory, Shenyang City's product.
Acetic acid, Changchun chemical reagent two factory product.
Chase after wind sheet, Longshunrong Pharmaceutical Factory, Tianjin Zhongxin Pharmaceutical Group Co., Ltd's product.
Animal: ICR mice, 18-22g, is provided by Beijing Vital River Experimental Animals Technology Co., Ltd.,
Credit number: SCXK (capital) 2002-2003.
Take healthy ICR mice, random point 4 groups, often organize 12.Test sets: matched group is (to physiology
Saline 20ml/kg)；Aspirin group；Chasing after wind extract group, respectively group gavage every day is once, gavage amount
For 20ml/kg, continuous 7 days, after last is administered 1 hour, each experimental group distilled water washed away medicinal liquid, used
Dry cotton ball is cleaned, and is only coated with dimethylbenzene 0.05ml/ to mouse right ear, and left ear compares, and puts to death after 30 minutes
Ears are cut with position homalographic by mice with the card punch of diameter 6mm, with electronic analytical balance respectively
Weighing, using ears weight difference as swelling level index, and obtain inhibitory rate of intumesce, result see table.
| Group | Swelling (mg) | Suppression ratio (%) |
| Matched group | 10.89±1.68 | |
| Aspirin group | 3.65±1.55 | 67.12 |
| Extract group | 4.30±1.51 | 65.13 |
| Chase after wind sheet | 4.65±1.52 | 61.25 |
Find out that the mice auricle swelling caused by extract xylol has obvious inhibitory action from upper table, and
Effect is better than chasing after wind sheet.
Claims (8)
1. a Chinese medicine composition for relaxing muscles and tendons to promote blood circulation, its active component is by following parts by weight
Raw material is made: 40 parts of Gypsum Fibrosum, Realgar 20 parts, Radix Aconiti Kusnezoffii Preparata 40 parts, Radix Aconiti Preparata 40 parts,
Rhizoma Typhonii (system) 20 parts, 20 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 60 parts, Radix Angelicae Sinensis 80 parts, Ramulus Cinnamomi 32
Part, Radix Dipsaci 80 parts, the Radix Paeoniae Alba 80 parts, Rhizoma Chuanxiong 80 parts, the Radix Angelicae Dahuricae 40 parts, Radix Saposhnikoviae 80 parts,
Arisaema Cum Bile 24 parts, Bombyx Batryticatus 80 parts, Pheretima 40 parts.
The Chinese medicine composition of a kind of relaxing muscles and tendons to promote blood circulation the most according to claim 1, its feature
It is that described active component uses following method to prepare: Gypsum Fibrosum powder is broken into fine powder, Realgar water
Fly or be ground into impalpable powder, standby.Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparata, Rhizoma Typhonii (crushing), Radix Glycyrrhizae.
Boiling secondary, 3 hours for the first time, 2 hours for the second time, half summer grade cold water soak was to thoroughly
Rhizoma Zingiberis 5g decocting in water secondary is added after the heart, 3 hours for the first time, 2 hours for the second time, more than merging
Aqueous extract, filters, and filtrate is condensed into the clear paste (50-of relative density 1.20～1.30
60℃).Radix Angelicae Sinensis ethanol 3 times amount reflux, extract, 8 hours, then return by 60% ethanol 3 times amount
Stream extracts secondary, 4 hours for the first time, second time 2 times amount ethanol extraction 2 hours, Ramulus Cinnamomi,
Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Arisaema Cum Bile 60% alcohol reflux three times；
Bombyx Batryticatus, Pheretima 25% alcohol reflux three times, the time is 6 hours for the first time, and second
Secondary 4 hours, 2 hours for the third time；Merge above ethanol extract, filter, reclaim ethanol dense
Shorten cream into, carry condensed cream with above-mentioned water and merge, add Gypsum Fibrosum, Realgar fine powder and auxiliary materials and mixing,
Make granule, be dried and let cool, mixing, obtain dried object A.
The Chinese medicine composition of a kind of relaxing muscles and tendons to promote blood circulation the most according to claim 2, its feature
Being: Gypsum Fibrosum powder is broken into fine powder, Realgar water flies or is ground into fine powder, standby.Radix Aconiti Kusnezoffii Preparata,
Radix Aconiti Preparata, Rhizoma Typhonii (crushing), Radix Glycyrrhizae boiling secondary, press medical material weight for the first time
10 times add water, and decoct 3 hours, and second time adds water by 8 times of medical material weight, decoct 2 little
Time, add Rhizoma Zingiberis 2.5kg decocting in water secondary after half summer grade cold water soak to the saturating heart, press medical material for the first time
10 times of weight add water, and decoct 3 hours, and second time adds water by 8 times of medical material weight, decoct
Boiling 2 hours, merge above aqueous extract, filter, filtrate is concentrated into relative density 1.20-1.30
(55℃).Radix Angelicae Sinensis ethanol 3 times amount reflux, extract, 8 hours, then with 60% ethanol 3 times
Amount reflux, extract, 4 hours, third time 2 times amount 60% ethanol extraction 2 hours；Ramulus Cinnamomi,
Radix Dipsaci, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Arisaema Cum Bile 60% alcohol reflux three times,
Pressing 3 extraordinarily 60% ethanol of medical material weight, reflux, extract, 6 hours for the first time, second time presses medicine
The 3 of material weight extraordinarily 60% ethanol, reflux, extract, 4 hours, third time presses the 2 of medical material weight
Extraordinarily 60% ethanol, reflux, extract, 2 hours；Bombyx Batryticatus, Pheretima are with 25% alcohol reflux three
Secondary, press for the first time 3 extraordinarily 25% ethanol of medical material weight, reflux, extract, 6 hours, for the second time
By 3 extraordinarily 25% ethanol of medical material weight, reflux, extract, 4 hours, third time presses medical material weight
2 extraordinarily 25% ethanol, reflux, extract, 2 hours；Merge above ethanol extract, filter,
Reclaim ethanol, be concentrated into relative density 1.20-1.30 (55 DEG C).By water extracting liquid and alcohol
Carry concentrated solution to merge, add Gypsum Fibrosum, Realgar fine powder and the auxiliary materials and mixing such as starch, dextrin, make
Granule, is dried and lets cool, and mixing obtains dried object A.
4. according to the Chinese medicine of a kind of relaxing muscles and tendons to promote blood circulation in any of the one of claims 1 to 3
Compositions, it is characterised in that: affiliated medicine is possibly together with the acceptable adjuvant of pharmaceutics.
The Chinese medicine composition of a kind of relaxing muscles and tendons to promote blood circulation the most according to claim 4, its feature
It is: the acceptable adjuvant of described pharmaceutics is selected from starch, microcrystalline Cellulose, sucrose, A Si
Ba Tian, dextrin, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium, crosslinking
Polyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, Fructus Citri Limoniae
Acid and sodium sulfite in any one or a few.
The Chinese medicine composition of a kind of relaxing muscles and tendons to promote blood circulation the most according to claim 4, its feature
Be: the dosage form of described Chinese medicine composition is peroral dosage form, including pill, tablet, capsule or
Oral liquid.
7. the preparation method of the Chinese medicine composition of a relaxing muscles and tendons to promote blood circulation, it is characterised in that: weigh
40 parts of Gypsum Fibrosum, Realgar 20 parts, Radix Aconiti Kusnezoffii Preparata 40 parts, Radix Aconiti Preparata 40 parts, Rhizoma Typhonii (system)
20 parts, 20 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 60 parts, Radix Angelicae Sinensis 80 parts, Ramulus Cinnamomi 32 parts, Radix Dipsaci 80
Part, the Radix Paeoniae Alba 80 parts, Rhizoma Chuanxiong 80 parts, the Radix Angelicae Dahuricae 40 parts, Radix Saposhnikoviae 80 parts, Arisaema Cum Bile 24
Part, Bombyx Batryticatus 80 parts, Pheretima 40 parts.Gypsum Fibrosum powder is broken into fine powder, and Realgar water flies or is ground into
Impalpable powder, standby.Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparata, Rhizoma Typhonii (crushing), Radix Glycyrrhizae.Boiling two
Secondary, 3 hours for the first time, 2 hours for the second time, half summer grade cold water soak added Rhizoma Zingiberis to the saturating heart
5g decocting in water secondary, 3 hours for the first time, 2 hours for the second time, merges above aqueous extract,
Filtering, filtrate is condensed into the clear paste (50-60 DEG C) of relative density 1.20～1.30.Radix Angelicae Sinensis
By ethanol 3 times amount reflux, extract, 8 hours, then with 60% ethanol 3 times amount reflux, extract, secondary,
4 hours for the first time, second time 2 times amount ethanol extraction 2 hours, Ramulus Cinnamomi, Radix Dipsaci, the Radix Paeoniae Alba,
Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Arisaema Cum Bile 60% alcohol reflux three times；Bombyx Batryticatus, Pheretima
With 25% alcohol reflux three times, the time is 6 hours for the first time, 4 hours for the second time,
2 hours for the third time；Merge above ethanol extract, filter, reclaim ethanol and be condensed into cream, with
Above-mentioned water carries condensed cream and merges, and adds Gypsum Fibrosum, Realgar fine powder and auxiliary materials and mixing, makes granule,
It is dried and lets cool, mixing, obtain dried object A.
A kind of relaxing muscles and tendons to promote blood circulation according to claim 1 the most according to claim 7
Chinese medicine composition, it is characterised in that: weigh 40 parts of Gypsum Fibrosum, Realgar 20 parts, Radix Aconiti Kusnezoffii Preparata 40
Part, Radix Aconiti Preparata 40 parts, Rhizoma Typhonii (system) 20 parts, 20 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 60 parts,
Radix Angelicae Sinensis 80 parts, Ramulus Cinnamomi 32 parts, Radix Dipsaci 80 parts, the Radix Paeoniae Alba 80 parts, Rhizoma Chuanxiong 80 parts, white
The root of Dahurian angelica 40 parts, Radix Saposhnikoviae 80 parts, Arisaema Cum Bile 24 parts, Bombyx Batryticatus 80 parts, Pheretima 40 parts.Stone
Cream is ground into fine powder, and Realgar water flies or be ground into fine powder, standby.Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparata,
Rhizoma Typhonii (crushing), Radix Glycyrrhizae boiling secondary, press for the first time the 10 of medical material weight extraordinarily
Water, decocts 3 hours, and second time adds water by 8 times of medical material weight, decocts 2 hours, the Rhizoma Pinelliae
With adding Rhizoma Zingiberis 2.5kg decocting in water secondary after cold water soak to the saturating heart, press medical material weight for the first time
10 times add water, and decoct 3 hours, and second time adds water by 8 times of medical material weight, decoct 2 little
Time, merging above aqueous extract, filter, filtrate is concentrated into relative density 1.20-1.30 (55 DEG C).
Radix Angelicae Sinensis ethanol 3 times amount reflux, extract, 8 hours, then by 60% ethanol 3 times amount reflux, extract, 4
Hour, third time 2 times amount 60% ethanol extraction 2 hours；Ramulus Cinnamomi, Radix Dipsaci, the Radix Paeoniae Alba,
Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Arisaema Cum Bile 60% alcohol reflux three times, press medicine for the first time
The 3 of material weight extraordinarily 60% ethanol, reflux, extract, 6 hours, second time presses the 3 of medical material weight
Extraordinarily 60% ethanol, reflux, extract, 4 hours, third time presses 2 extraordinarily 60% second of medical material weight
Alcohol, reflux, extract, 2 hours；Bombyx Batryticatus, Pheretima 25% alcohol reflux three times, for the first time
By 3 extraordinarily 25% ethanol of medical material weight, reflux, extract, 6 hours, second time presses medical material weight
3 extraordinarily 25% ethanol, reflux, extract, 4 hours, third time press the 2 extraordinarily 25% of medical material weight
Ethanol, reflux, extract, 2 hours；Merge above ethanol extract, filter, reclaim ethanol, dense
It is reduced to relative density 1.20-1.30 (55 DEG C).Water extracting liquid and alcohol extraction concentrated solution are merged,
Add Gypsum Fibrosum, Realgar fine powder and the auxiliary materials and mixing such as starch, dextrin, make granule, be dried and let cool,
Mixing, obtains dried object A.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929448A (en) * | 2017-12-25 | 2018-04-20 | 贵州健瑞安药业有限公司 | Relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue is promoted to foam foot prescription and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107929448A (en) * | 2017-12-25 | 2018-04-20 | 贵州健瑞安药业有限公司 | Relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue is promoted to foam foot prescription and preparation method thereof |
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Application publication date: 20160824 |