CN1923244B - Medicinal composition for treating dermatosis, preparation process and use thereof - Google Patents
Medicinal composition for treating dermatosis, preparation process and use thereof Download PDFInfo
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- CN1923244B CN1923244B CN200610058670A CN200610058670A CN1923244B CN 1923244 B CN1923244 B CN 1923244B CN 200610058670 A CN200610058670 A CN 200610058670A CN 200610058670 A CN200610058670 A CN 200610058670A CN 1923244 B CN1923244 B CN 1923244B
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Abstract
Disclosed is a pharmaceutical composition for treating skin diseases which comprises the following components (by weight ratio): ginseng 20-40 parts, astragalus root 30-80 parts, capsule of weeping forsythia 5-20 parts, ledebouriella root 10-40 parts, notopterygium root 5-30 parts, levisticum 5-50 parts, flavescent sophora root 10-50 parts, phellodendron bark 5-20 parts, broom cypress fruit 10-30parts, cnidium fruit 10-30 parts, centipede, cassia seed 5-20 parts, hornet nest 10-30 parts, licorice root 5-30 parts, herba schizonepetae 5-20 parts, peppermint 5-20 parts, antelope's horn 10-80 parts, cocklebur fruit 10-50 parts, black-tail snake 10-80 parts, dried human placemta 10-30 parts, agkistrodon acutus 10-50 parts, coralbean bark 5-30 parts, secretio bufonis 10-30 parts, ophicalcite 10-50 parts, lead monoxide 10-50 parts, large-leaf gentian root 10-80 parts, and musk 5-20 parts.
Description
Technical field
The present invention relates to pharmaceutical composition of a kind of treatment dermatosis, particularly pruritus and its production and application.
Background technology
Dermatosis is a kind of commonly encountered diseases, and dermopathic symptom is divided into two kinds of subjective symptoms and objective sign shapes.Wherein subjective symptoms is meant the symptom that patient's subjective sensation arrives, relevant with dermopathic character, the order of severity and the individual patients opposite sex, mainly contain itch, bitterly, sensation such as burn feeling and numbness, and the most multiple subjective symptoms is a gargalesthesia, it is modal subjective symptoms, the degree weight of itching differs, and paroxysmal and persistence are arranged, limitation and popularity.Gargalesthesia can gently can weigh, and sustainablely also can be interrupted outbreak, can be the whole body pruritus also can limit office in a certain position; With a kind of pruritus disease, because the sensitivity difference, on one's body or cause gargalesthesia in various degree in different people.Contact dermatitis, eczema, urticaria etc. itch the pain often heavier.Some systemic disease such as malignant lymphoma, diabetes, jaundice and renal function are that congruence can cause gargalesthesia.Scalp, pudendum, ear and toe seam etc. are located normal generation office property pruritus.Senile pruritus is common in winter, and what have is relevant with xerosis cutis.The mechanism of itching be it is generally acknowledged: 1. by the free sensory nerve end of high dermis in the epidermis slightly, accept to stimulate to cause gargalesthesia by lateral ridge mound Shu Chuanzhi Thalamus and sensory centre; 2. discharge some chemical substance with body such as histamine, kassinin kinin and protease etc. are relevant, especially protease plays important chemical mediator effect, it all has existence in epidermis, blood, antibacterial and fungus, wound or some reason can discharge activation in tissue, produces skin pruritus.
Some treatment dermatosiss are arranged in the prior art, the medicine of skin itching particularly, for example, application number is that the Chinese patent of CN92114544.6 discloses a kind of strong rash-disappearing antipruritic and production method thereof, it adds Radix Arnebiae (Radix Lithospermi), Cortex Dictamni, Fructus Forsythiae, Herba Plantaginis on the basis of ancient prescription " Decoction of Gentiana for Purging the Liver-fire ", and reuses Radix Scutellariae and Radix Gentianae among the former side; Application number is that the Chinese patent application of CN02132451.4 discloses a kind of quick-acting antalgesic-antipruritic tincture, it is Fructus Evodiae, Olibanum, Myrrha, Rhizoma Corydalis, the Radix Stemonae, Fructus Piperis Longi, Benzoinum, Borneolum Syntheticum, dried Alumen to be pulverized the back add in the ethanol, room temperature soaks down, camphorate again, Mentholum, Storax oil, stir, filter and to obtain.But antipruritic agent of the prior art is medicine for external use substantially, and oral drugs seldom.
Summary of the invention
The oral pure Chinese medicine pharmaceutical composition that the objective of the invention is to a kind of treatment dermatosis, particularly skin itching, and these preparation of drug combination methods and applications.
The dermopathic pharmaceutical composition of treatment provided by the invention comprises following components by weight ratio: Radix Ginseng 20-40 part, Radix Astragali 30-80 part, Fructus Forsythiae 5-20 part, Radix Saposhnikoviae 10-40 part, Rhizoma Et Radix Notopterygii 5-30 part, Radix Angelicae Pubescentis 5-50 part, Radix Sophorae Flavescentis 10-50 part, Fructus Tribuli (CIJILI) 10-50 part, Cortex Phellodendri 5-20 part, the Fructus Kochiae (fructus kochiae) 10-30 part, Fructus Cnidii 10-30 part, Scolopendra, Semen Momordicae (MUBIEZI) 5-20 part, Bombyx Batryticatus (Rhizoma Zingiberis Recens silkworm) 5-30 part, Nidus Vespae 10-30 part, SHENGCAO 5-30 part, Herba Schizonepetae 5-20 part, Herba Menthae (Bu He) 5-20 part, Cornu Saigae Tataricae 10-80 part, Fructus Xanthii 10-50 part, Zaocys 10-80 part, Placenta Hominis 10-30 part, Agkistrodon 10-50 part, Cortex erythrinae 5-30 part, Bufo siccus 10-30 part, Ophicalcitum 10-50 part, Lithargyrum 10-50 part, Radix Gentianae Macrophyllae (Wan of the Qin) 10-80 part, Moschus 5-20 part; Wherein, Scolopendra is the 10-30 bar when Radix Ginseng is 20-40g, and when changing as if the Radix Ginseng consumption, then the Scolopendra consumption is as reference increase and decrease in proportion.In present specification, the weight of every Scolopendra is 1 gram.
This pharmaceutical composition preferably includes following components by weight ratio: 30 parts of Radix Ginsengs, 50 parts of the Radixs Astragali, 10 parts of Fructus Forsythiaes, 20 parts of Radix Saposhnikoviaes, 15 parts of Rhizoma Et Radix Notopterygiis, 15 parts of Radix Angelicae Pubescentiss, 30 parts of Radix Sophorae Flavescentiss, 30 parts of Fructus Tribulis (CIJILI), 10 parts of Cortex Phellodendris, 20 parts of the Fructus Kochiae (fructus kochiae), 20 parts of Fructus Cnidiis, Scolopendra, 10 parts of Semen Momordicaes (MUBIEZI), 15 parts of Bombyx Batryticatus (Rhizoma Zingiberis Recens silkworm), 20 parts in Nidus Vespae, 15 parts of SHENGCAO, 10 parts of Herba Schizonepetae, 10 parts of Herba Menthaes (Bu He), 50 parts of Cornu Saigae Tataricae, 30 parts of Fructus Xanthii, 50 parts of Zaocys, 20 parts of Placenta Hominiss, 30 parts of Agkistrodons, 15 parts of Cortex erythrinaes, 20 parts of Bufo siccuss, 30 parts of Ophicalcitums, 30 parts of Lithargyrums, 50 parts of Radix Gentianae Macrophyllae (Wan of the Qin), 10 parts in Moschus; Wherein, Scolopendra is 20 when Radix Ginseng is 30g, and when changing as if the Radix Ginseng consumption, then the Scolopendra consumption is as reference increase and decrease in proportion. the weight of every Scolopendra is 1 gram.
Sea of the present invention provides the preparation method of aforementioned pharmaceutical compositions, and this method comprises that it is powder that all the components is pulverized, and mixes getting final product.Obtaining on the mixed drug powder basis, can conventional method according to the present invention make peroral dosage forms such as powder, capsule, tablet, granule, pill.
The instructions of taking of pharmaceutical composition of the present invention: count 10 grams with crude drug weight every day 2 times at every turn, use warm water delivery service, be 30 days a course of treatment, and period in a medicine is avoided clothes pork, Chinese liquor.Sick time person below 10 years can cure a general course of treatment, and sick time reaches that the general 4-5 of person can cure the course of treatment more than 10 years.
Dermatosis is a kind of pertinacious disease very complicated, refractory, disease in its cause of disease belongs to, and main pathological changes is paced up and down in cellular blood, and is sick extra-, and the cause of disease is interior, can remove virus in the blood of human body with Chinese medicine composition of the present invention, reaches the purpose of rehabilitation and recovery from illness.Pharmaceutical composition of the present invention has heat clearing away, the wind that looses, detoxifcation, removing heat from blood, dehumidifying, effect such as antipruritic, to various dermatosiss, as trick tinea, tinea corporis and cruris, herpes, contact dermatitis, eczema, urticaria, neurodermatitis, psoriasis (psoriasis) etc. good curative effect is arranged, especially dermopathic pruritus is had extraordinary therapeutic effect, the clinical statistics result shows that total effective rate reaches 98%.
The inventor adds up clinical case, and the result is as follows:
| Dermatosis | Example number/people | Healing/people | Produce effects/people | Effectively/people | Invalid/people | Total effectively people (%) |
| Eczema | 30 | 28 | 1 | 1 | 0 | 29(96.66) |
| Urticaria | 35 | 32 | 2 | 1 | 0 | 34(97.4) |
| Psoriasis | 80 | 67 | 7 | 4 | 2 | 74(92.5) |
| Neurodermatitis | 84 | 70 | 9 | 4 | 1 | 79(94) |
| 7994 skin prurituss | 30 | 25 | 4 | 1 | 0 | 29(96.66) |
Wherein, observe skin itching by heavy, in, light, no level Four scores, and counts respectively 3,2,1,0 fens, specifically see the following form:
The symptom of scratching where it itches classification score-sheet
| Degree | Severe | Poison | Slightly | Do not have |
| Score | 3 | 2 | 1 | 0 |
| Degree | Severe | Poison | Slightly | Do not have |
| The degree of scratching where it itches | It is violent to scratch where it itches, and frequent outbreak obviously influences work and sleep | It is heavier to scratch where it itches, and show effect 3-5 every day, and can stand daytime, and have certain influence to sleep night | It is lighter to scratch where it itches, and show effect 1-2 every day, does not influence work and sleep | Nothing is scratched where it itches |
| The scratch number | Scratch＞30 | Article 30,＞scratch＞10 | Scratch＜10 | Do not have |
| The blood crusts number | Blood crusts＞30 | 30＞blood crusts＞10 | Blood crusts＜10 | Do not have |
The therapeutic evaluation standard:
Clinical cure: the complete obiteration of scratching where it itches, the symptom score reduces more than 95% before the treatment.Produce effects: scratching where it itches obviously alleviates, and the symptom score reduces 70-95% before the treatment.Effectively: scratching where it itches alleviates, and the symptom score reduces 30-69% before the treatment.Invalid: scratching where it itches, it is not obvious to improve, and the symptom score reduces＜30% before the treatment.
Total effective rate=clinical cure rate+obvious effective rate
The specific embodiment
Further describe the present invention below in conjunction with embodiment.
Embodiment 1
Remove Radix Ginseng 30 grams, the Radix Astragali 50 grams, Fructus Forsythiae 10 grams, Radix Saposhnikoviae 20 grams, Rhizoma Et Radix Notopterygii 15 grams, Radix Angelicae Pubescentis 15 grams, Radix Sophorae Flavescentis 30 grams, Fructus Tribuli (CIJILI) 30 grams, Cortex Phellodendri 10 grams, the Fructus Kochiae (fructus kochiae) 20 grams, Fructus Cnidii 20 grams, 20 of Scolopendras (totally 20 grams), Semen Momordicae (MUBIEZI) 10 grams, Bombyx Batryticatus (Rhizoma Zingiberis Recens silkworm) 15 grams, Nidus Vespae 20 grams, SHENGCAO 15 grams, Herba Schizonepetae 10 grams, Herba Menthae (Bu He) 10 grams, Cornu Saigae Tataricae 50 grams, Fructus Xanthii 30 grams, Zaocys 50 grams, Placenta Hominis 20 grams, Agkistrodon 30 grams, Cortex erythrinae 15 grams, Bufo siccus 20 grams, Ophicalcitum 30 grams, Lithargyrum's 30 grams, Radix Gentianae Macrophyllae (Wan of the Qin) 50 grams, Moschus 10 grams, pulverize, the gained powder mixes is even, with the specification packing of 10 gram/bags.
Embodiment 2
Get Radix Ginseng 20 grams, the Radix Astragali 30 grams, Fructus Forsythiae 5 grams, Radix Saposhnikoviae 10 grams, Rhizoma Et Radix Notopterygii 5 grams, Radix Angelicae Pubescentis 5 grams, Radix Sophorae Flavescentis 50 grams, Fructus Tribuli (CIJILI) 50 grams, Cortex Phellodendri 5 grams, the Fructus Kochiae (fructus kochiae) 30 grams, Fructus Cnidii 10 grams, 10 of Scolopendras (totally 10 grams), Semen Momordicae (MUBIEZI) 20 grams, Bombyx Batryticatus (Rhizoma Zingiberis Recens silkworm) 30 grams, Nidus Vespae 10 grams, SHENGCAO 30 grams, Herba Schizonepetae 20 grams, Herba Menthae (Bu He) 5 grams, 80 parts of Cornu Saigae Tataricae grams, Fructus Xanthii 10 grams, Zaocys 10 grams, Placenta Hominis 30 grams, Agkistrodon 10 grams, Cortex erythrinae 30 grams, Bufo siccus 10 grams, Ophicalcitum 10 grams, Lithargyrum's 50 grams, Radix Gentianae Macrophyllae (Wan of the Qin) 10 grams, Moschus 5 grams are pulverized, and fill is a capsule.
Embodiment 3
Radix Ginseng 40 grams, the Radix Astragali 80 grams, Fructus Forsythiae 5 grams, Radix Saposhnikoviae 40 grams, Rhizoma Et Radix Notopterygii 30 grams, Radix Angelicae Pubescentis 5 grams, Radix Sophorae Flavescentis 10 grams, Fructus Tribuli (CIJILI) 50 grams, Cortex Phellodendri 20 grams, the Fructus Kochiae (fructus kochiae) 10 grams, Fructus Cnidii 10 grams, 30 of Scolopendras (totally 30 grams), Semen Momordicae (MUBIEZI) 20 grams, Bombyx Batryticatus (Rhizoma Zingiberis Recens silkworm) 5 grams, Nidus Vespae 10 grams, SHENGCAO 30 grams, Herba Schizonepetae 20 grams, Herba Menthae (Bu He) 20 grams, Cornu Saigae Tataricae 80 grams, Fructus Xanthii 50 grams, Zaocys 10 grams, Placenta Hominis 30 grams, Agkistrodon 10 grams, Cortex erythrinae 30 grams, Bufo siccus 30 grams, Ophicalcitum 50 grams, Lithargyrum's 50 grams, Radix Gentianae Macrophyllae (Wan of the Qin) 80 grams, Moschus 20 grams, all raw material powders are broken into powder, and mix homogeneously is with the specification packing of 10 gram/bags.
Claims (4)
1. the dermopathic pharmaceutical composition of treatment is made up of following components by weight ratio: Radix Ginseng 20-40 part, Radix Astragali 30-80 part, Fructus Forsythiae 5-20 part, Radix Saposhnikoviae 10-40 part, Rhizoma Et Radix Notopterygii 5-30 part, Radix Angelicae Pubescentis 5-50 part, Radix Sophorae Flavescentis 10-50 part, Fructus Tribuli 10-50 part, Cortex Phellodendri 5-20 part, Fructus Kochiae 10-30 part, Fructus Cnidii 10-30 part, Scolopendra, Semen Momordicae 5-20 part, Bombyx Batryticatus 5-30 part, Nidus Vespae 10-30 part, SHENGCAO 5-30 part, Herba Schizonepetae 5-20 part, Herba Menthae 5-20 part, Cornu Saigae Tataricae 10-80 part, Fructus Xanthii 10-50 part, Zaocys 10-80 part, Placenta Hominis 10-30 part, Agkistrodon 10-50 part, Cortex erythrinae 5-30 part, Bufo siccus 10-30 part, Ophicalcitum 10-50 part, Lithargyrum 10-50 part, Radix Gentianae Macrophyllae 10-80 part, Moschus 5-20 part; Wherein, Scolopendra is the 10-30 bar when Radix Ginseng is 20-40g.
2. pharmaceutical composition as claimed in claim 1 is characterized in that, this pharmaceutical composition is made up of following components by weight ratio:
30 parts of Radix Ginsengs, 50 parts of the Radixs Astragali, 10 parts of Fructus Forsythiaes, 20 parts of Radix Saposhnikoviaes, 15 parts of Rhizoma Et Radix Notopterygiis, 15 parts of Radix Angelicae Pubescentiss, 30 parts of Radix Sophorae Flavescentiss, 30 parts of Fructus Tribulis, 10 parts of Cortex Phellodendris, 20 parts of the Fructus Kochiae, 20 parts of Fructus Cnidiis, Scolopendra, 10 parts of Semen Momordicaes, 15 parts of Bombyx Batryticatus, 20 parts in Nidus Vespae, 15 parts of SHENGCAO, 10 parts of Herba Schizonepetae, 10 parts of Herba Menthaes, 50 parts of Cornu Saigae Tataricae, 30 parts of Fructus Xanthii, 50 parts of Zaocys, 20 parts of Placenta Hominiss, 30 parts of Agkistrodons, 15 parts of Cortex erythrinaes, 20 parts of Bufo siccuss, 30 parts of Ophicalcitums, 30 parts of Lithargyrums, 50 parts of Radix Gentianae Macrophyllae, 10 parts in Moschus; Wherein, Scolopendra is 20 when Radix Ginseng is 30g.
3. prepare the method for the pharmaceutical composition of claim 1 or 2, this method comprises: all raw medicinal materials are ground into powder, mix getting final product.
4. the pharmaceutical composition as claim 1 or 2 is preparing the application for the treatment of in the dermopathic medicine.
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| CN200610058670A CN1923244B (en) | 2006-03-06 | 2006-03-06 | Medicinal composition for treating dermatosis, preparation process and use thereof |
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| CN1923244B true CN1923244B (en) | 2010-05-12 |
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Cited By (2)
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| CN106176875A (en) * | 2016-08-26 | 2016-12-07 | 张龙元 | A kind of vulnerary compositions and preparation method |
| CN109846823A (en) * | 2019-02-15 | 2019-06-07 | 李玉良 | A kind of medicinal herb spray and preparation method thereof for treating shingles zoster |
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| CN102068635B (en) * | 2010-12-31 | 2012-05-23 | 谭曜 | Traditional Chinese medicine for treating refractory pruritus |
| CN102716243B (en) * | 2012-05-31 | 2013-10-09 | 蒋保珍 | Externally applied traditional Chinese medicine composite for treating body yellowing disease of horses |
| CN102846914B (en) * | 2012-09-26 | 2015-04-15 | 张永红 | Medicine for treating neurodermatitis and preparation method thereof |
| CN103638482B (en) * | 2013-11-20 | 2015-08-05 | 蒋学 | A kind of medicine for the treatment of chronic urticaria and preparation method thereof |
| CN103721054B (en) * | 2014-01-16 | 2016-02-17 | 太仓苏易信息科技有限公司 | A kind of preparation method of urticaria drug |
| CN105079197A (en) * | 2015-07-20 | 2015-11-25 | 叶盛德 | Ointment for relieving and treating scabies and having cosmetic effect |
| CN105055554A (en) * | 2015-07-20 | 2015-11-18 | 叶盛德 | Plaster used for relieving and treating scabies |
| CN105287705A (en) * | 2015-10-26 | 2016-02-03 | 唐贝宁医药科技（北京）有限公司 | Traditional Chinese medicine preparation for specially treating difficult skin diseases and preparation method thereof |
| CN106138939A (en) * | 2016-07-09 | 2016-11-23 | 曹湖云 | A kind of medicine treating neurodermatitis and preparation method |
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| CN1413627A (en) * | 2002-05-04 | 2003-04-30 | 付研彪 | Medicine for treating dematosis |
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|---|---|---|---|---|
| CN1413627A (en) * | 2002-05-04 | 2003-04-30 | 付研彪 | Medicine for treating dematosis |
Non-Patent Citations (3)
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| 刘道清.中药名大典.中原农民出版社,1994,493-494. * |
| 石海燕.中医药辨治皮肤病验案3例.四川中医22 8.2004,22(8),84-85. |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176875A (en) * | 2016-08-26 | 2016-12-07 | 张龙元 | A kind of vulnerary compositions and preparation method |
| CN109846823A (en) * | 2019-02-15 | 2019-06-07 | 李玉良 | A kind of medicinal herb spray and preparation method thereof for treating shingles zoster |
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