CN105326899A - Traditional Chinese medicine for treating leukoderma and preparation method for traditional Chinese medicine - Google Patents
Traditional Chinese medicine for treating leukoderma and preparation method for traditional Chinese medicine Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a traditional Chinese medicine for treating leukoderma and a preparation method. The medicine is prepared from a water-decocting extract of false Chinese swertia herb, an ethanol solution extract of field horsetail, and elderberry seed oil. The preparation method comprises the following steps: 1, adding water into the false Chinese swertia herb, decocting with slow fire after the water is boiled, removing dregs, concentrating, drying and crushing to obtain medicinal powder; 2, adding the aqueous solution of ethanol into the field horsetail, warming, soaking, extracting, removing dregs, concentrating the extract solution, drying, and crushing the dried concentrate to obtain medicinal powder; 3, first, soaking elderberry seeds with the aqueous solution of ethanol, fishing out and drying the elderberry seeds, and crushing the dried elderberry seeds into coarse powder; then, extracting the elderberry seed oil from the obtained coarse powder by using the aqueous solution of ethanol, and mixing the obtained components to obtain the traditional Chinese medicine for treating leukoderma. The traditional Chinese medicine for treating leukoderma and the preparation method for the traditional Chinese medicine have the positive effects that the compatibility and the dosage are determined through analysis and test according to the medicinal efficacy of the selected components, the raw materials cooperate with each other, the medicinal function of the formed medicinal composition is played to the greatest extent, and the traditional Chinese medicine for treating leukoderma, which is accurate in treatment effect, high in cure rate, and low in manufacturing cost, does not have a side effect and has easily obtained raw materials is obtained.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to treat leukodermic Chinese medicine.
Background technology
Vitiligo disease, just on the books in medical information in early days, belong to the disease having longer history of existence, there is no more gratifying medicine so far, belong to genuine difficult and complicated illness.Along with air, water, food cause quality variation because of environmental pollution, the quickening of social development paces causes the stress of all kinds of crowd in life, work to strengthen, cause the multiple of body pathogenic disease in recent years, naturally also wherein, patients with vitiligo is more common for vitiligo.The leukodermic Western medicine of current treatment, mostly is external, without radical cure effect, and also containing hormone in some curative, has side effect.Before this, treat leukodermic Chinese patent medicine or prescription although society spreads, also there is no the kind by the public or the comparatively unified accreditation of medical profession because of determined curative effect.Therefore, vitiligo is current is still difficult and complicated illness, though some patients through long-term diagnosis and treatment, expend huge fund and do not heal.Although not threat to life, patient bears heavy mental burden.
Summary of the invention
The object of this invention is to provide one and treat leukodermic Chinese medicine and preparation method, be used for the treatment of vitiligo, overcome existing treatment leucoderma medicament cure rate low, the deficiency that curative effect is not obvious, medical expense is high.
Medicine of the present invention comprises: the water decoction extract 50-70 weight portion of Herba Swertiae bimaculatae, the alcoholic solution extract 20-40 weight portion of Herba Equiseti Arvinsis, Ramulus Sambuci Williamsii seed oil 3-8 weight portion, excipient right amount of auxiliary materials.
Medicine optimum feed stock usage ratio of the present invention is: water decoction extract 60 weight portion of Herba Swertiae bimaculatae, alcoholic solution extract 30 weight portion of Herba Equiseti Arvinsis, Ramulus Sambuci Williamsii seed oil 5 weight portions.
The excipient adjuvant preferred starch of drug oral agent of the present invention or Radix Angelicae Dahuricae powder; The preferred vaseline of excipient adjuvant of outer varnish; The consumption of starch or Radix Angelicae Dahuricae powder is 1-1.5 times of extract gross weight; Vaseline consumption is 1.5-2.5 times of extract gross weight.
Preparation method of the present invention is:
1, get Herba Swertiae bimaculatae, decoct with water extraction, the Aqueous extracts after slagging-off is concentrated, dry, pulverize medicated powder is for subsequent use;
2, get Herba Equiseti Arvinsis and add the warm soak extraction of ethanol water, concentrated extracting solution after slagging-off also reclaims ethanol, and extract dry, pulverize medicated powder is for subsequent use;
3, Ramulus Sambuci Williamsii seed is got, first soak except the composition in sarcocarp with ethanol water, then pull Ramulus Sambuci Williamsii seed out to dry, smash into coarse powder to pieces, gained coarse powder is added again ethanol water soak extraction Ramulus Sambuci Williamsii seed oil, ethanol water addition was as the criterion not have (upper surface that liquid level is piled up higher than medicated powder), when liquid level accumulation oil slick, extract oil slick, evaporating off water and ethanol, obtain Ramulus Sambuci Williamsii seed oil.
4, get step 1 gained Herba Swertiae bimaculatae water extract powder 50-70 weight portion, the alcoholic solution extract powder 20-40 weight portion of step 2 gained Herba Equiseti Arvinsis, the mixing of step 3 gained Ramulus Sambuci Williamsii seed oil 3-8 weight portion, the medicinal ingredient of leukodermic Chinese medicine must be treated.
5, conventional oral dosage formulations is made after step 4 gained medicinal ingredient being added the mixing of appropriate oral agents excipient adjuvant, vitiligo medicinal preparation for oral administration must be treated, or step 4 gained medicinal ingredient is added appropriate external become cream excipient adjuvant, mix homogeneously, leukodermic external must be treated and smear unguentum.
Wherein:
In step 1, Herba Swertiae bimaculatae amount of water is 4-6 times of Herba Swertiae bimaculatae weight; Decoction method decocts 2-3 hour for boiling rear slow fire;
In step 2, it is 40-70% that Herba Equiseti Arvinsis ethanol water extracts the concentration of alcohol (volume ratio) added, Extracting temperature 40-60 DEG C, soak time 4-6 hour;
In step 3, Ramulus Sambuci Williamsii seed is except fruit flesh component one step, the concentration of added ethanol water is 30-60%, soak time 4-8 days, Ramulus Sambuci Williamsii seed oil one step is extracted with Ramulus Sambuci Williamsii coarse powder, added ethanol water concentration 30-60%, ethanol water addition was as the criterion not have (upper surface that liquid level is piled up higher than medicated powder);
Medicine of the present invention both can take orally, and also can be coated with in addition, to take orally, oral dose is adult 3 grams/day (by medicinal active ingredient), point three clothes.Be painted with affected part to be outward coated with 2-4 time every day.
The present invention be based on:
Herba Swertiae bimaculatae: there is enzyme system, the promotion skin oxidative restoring function expanding blood capillary, activation or promote Skin Cell.
Herba Equiseti Arvinsis: Herba Equiseti Arvinsis extract has very strong increment effect (promotion rate 221) to melanocyte.(cosmetics plant material handbook, Wang Jianxin chief editor, Chemical Industry Press)
Ramulus Sambuci Williamsii: have increment effect (appreciation rate 152) to melanocyte in fruit extract.(cosmetics plant material handbook, Wang Jianxin chief editor, Chemical Industry Press)
Good effect of the present invention is: by the medicinal efficacy of selected composition, by analysis, test confirms compatibility consumption, reach each raw material mutually to work in coordination with, play the medicinal function of pharmaceutical composition formed to greatest extent, obtain a kind of determined curative effect, cure rate high, have no side effect, raw material is easy to get, therapy of vitiligo Chinese medicine cheap for manufacturing cost.Put into practice the treatment of 1134 routine patients through the several years, 1018 examples of having fully recovered, cure rate is close to 81%, and remainder is among treatment.And medical expense is low, medicine source sufficient, compared with existing identical treatment object medicine, instant effect, short treating period, medical expense are low.
Case is illustrated:
Gold ××, man, nineteen sixty-five life, firmly Jilin.Examine over 2011, readme before 3 years City Hospitals be diagnosed as vitiligo, in many ways see a doctor to no effect, spent more than 30,000 yuan, whole body distribution of examining that to be focus be, denomination, arm all have obvious bulk frosty area, take medicine of the present invention recovery from illness in 15 months.Follow up a case by regular visits to and do not recur so far.
Xu's ××, man's nineteen sixty life, firmly huge rock county of Jilin Province.Examine over 2009, readme is the existing greyish white color lump of thigh before 5 years, then to upper body part development, has no result until denomination, arm are sought medical advice in many ways.Examine meeting neck, hands and breast, the back of the body, extremity all have distribution, take medicine of the present invention recovery from illness in 17 months.Follow up a case by regular visits to and do not recur so far.
Lee's ××, female, life in 1973, firmly Changchun, found that there was the color lump that turns white shirtfront before 4 years, be then developed to neck, face.Seek medical advice everywhere and do not feel any better more than a year, have on the contrary and increase the weight of sign, examine at the end of 2013, neck, face respectively have the large mottle of place's Semen Juglandis, and there is rim of a cup size day shift shirtfront.Take medicine of the present invention 14 months, mottle disappears, and follows up a case by regular visits to and does not recur.
Du's ××, female, life in 1993, (not agreeing to provide address).Found before readme half a year when within 2013, the summer examines that right forearm has greyish white color lump, develops into right hand the back of the hand then, examine see right forearm, right hand the back of the hand has coin-size white blocks three place, takes medicine of the present invention recovery from illness in 12 months.Follow up a case by regular visits to and do not recur so far.
Yuan's ××, man, life in 2009, (not agreeing to provide address).The spring head of a family in 2013 finds that its waist has out-of-shape Semen Juglandis size white mottle, then causes vigilant, is vitiligo, examines upon somebody's introduction to certain medical university's hospital diagnosis, and 7 months mottles of taking medicine disappear, and do not recur so far.
Detailed description of the invention
Embodiment one
1, get Herba Swertiae bimaculatae, add the water of got Herba Swertiae bimaculatae weight 6 times, bubble open, boil rear slow fire and decoct 2 hours, slagging-off, by concentrated for Aqueous extracts, dry, pulverize medicated powder is for subsequent use;
2, get Herba Equiseti Arvinsis and be ground into coarse powder, add ethanol water 40 DEG C of soak extraction 6 hours of concentration (volume ratio) 70%, leach extracting solution, medicinal residues add the ethanol water of afore mentioned concentration, consumption again, again extract 6 hours, waste, merge extracted twice liquid, concentrated, recovery ethanol, concentrate dry, pulverize medicated powder is for subsequent use;
3, Ramulus Sambuci Williamsii seed is got, first soak 8 days with concentration 30% ethanol water, then pull Ramulus Sambuci Williamsii seed out to dry, smash into coarse powder to pieces, gained coarse powder is added concentration 60% ethanol water and extract Ramulus Sambuci Williamsii seed oil, ethanol water addition was as the criterion not have (upper surface that liquid level is piled up higher than medicated powder), when liquid level accumulation oil slick, extract oil slick, evaporate moisture and ethanol, obtain Ramulus Sambuci Williamsii seed oil.
4, get step 1 gained Herba Swertiae bimaculatae water extract powder 70 weight portion, alcoholic solution extract powder 20 weight portion of step 2 gained Herba Equiseti Arvinsis, the mixing of step 3 gained Ramulus Sambuci Williamsii seed oil 8 weight portion, the medicinal ingredient of leukodermic Chinese medicine must be treated.
5, starch step 4 gained medicinal ingredient being added its 1.5 times of weight makes tablet, must treat vitiligo medicinal preparation for oral administration, gained medicinal ingredient be added the vaseline of its 1 times of weight, mix homogeneously, must treat leukodermic external and smear unguentum.
Embodiment two
1, get Herba Swertiae bimaculatae, add the water of got Herba Swertiae bimaculatae weight 4 times, bubble open, boil rear slow fire and decoct 3 hours, leach medicinal liquid, abandon medicinal residues, by concentrated for Aqueous extracts, dry, pulverize medicated powder is for subsequent use;
2, get Herba Equiseti Arvinsis and be ground into coarse powder, add ethanol water 60 DEG C of soak extraction 5 hours of concentration (volume ratio) 40%, leach extracting solution, medicinal residues add the ethanol water of afore mentioned concentration and weight again, 60 DEG C of soak extraction 5 hours, waste, merge extracted twice liquid, reclaim ethanol concentrated extracting solution, concentrate dry, pulverize medicated powder is for subsequent use;
3, Ramulus Sambuci Williamsii seed is got, first soak 4 days with concentration 60% ethanol water, then pull Ramulus Sambuci Williamsii seed out to dry, smash into coarse powder to pieces, gained coarse powder is added concentration 30% ethanol water and extract Ramulus Sambuci Williamsii seed oil, ethanol water addition was as the criterion not have (upper surface that liquid level is piled up higher than medicated powder), (about a week) extraction oil slick when liquid level accumulation oil slick, transpiring moisture and ethanol, obtain Ramulus Sambuci Williamsii seed oil.
4, get step 1 gained Herba Swertiae bimaculatae water extract powder 50 weight portion, alcoholic solution extract powder 40 weight portion of step 2 gained Herba Equiseti Arvinsis, the mixing of step 3 gained Ramulus Sambuci Williamsii seed oil 5 weight portion, the medicinal ingredient of leukodermic Chinese medicine must be treated.
5, starch step 4 gained medicinal ingredient being added its 1 times of weight makes the watered pill, must treat vitiligo medicinal preparation for oral administration, gained medicinal ingredient be added the vaseline of its 1.5 times of weight, mix homogeneously, must treat leukodermic external and smear unguentum.
Embodiment three
1, get Herba Swertiae bimaculatae, add the water of got Herba Swertiae bimaculatae weight 5 times, bubble open, boil rear slow fire and decoct 2.5 hours, slagging-off, by concentrated for Aqueous extracts, dry, pulverize medicated powder is for subsequent use;
2, get Herba Equiseti Arvinsis and be ground into coarse powder, add ethanol water 50 DEG C of soak extraction 4 hours of concentration (volume ratio) 50%, leach extracting solution, medicinal residues are added again the ethanol water of afore mentioned concentration, weight, 50 DEG C of soak extraction 4 hours, liquid concentration and recovery ethanol is got in merging, concentrate dry, pulverize medicated powder is for subsequent use;
3, Ramulus Sambuci Williamsii seed is got, first soak 6 days with concentration 50% ethanol water, then pull Ramulus Sambuci Williamsii seed out to dry, smash into coarse powder to pieces, gained coarse powder is added low concentration 50% ethanol water and extract Ramulus Sambuci Williamsii seed oil, ethanol water addition was as the criterion not have (upper surface that liquid level is piled up higher than medicated powder), when liquid level accumulation oil slick, extract oil slick, evaporate the moisture and ethanol that are mixed into, obtain Ramulus Sambuci Williamsii seed oil.
4, get step 1 gained Herba Swertiae bimaculatae water extract powder 60 weight portion, alcoholic solution extract powder 30 weight portion of step 2 gained Herba Equiseti Arvinsis, the mixing of step 3 gained Ramulus Sambuci Williamsii seed oil 3 weight portion, the ingredient of leukodermic Chinese medicine must be treated.
5, Radix Angelicae Dahuricae powder step 4 gained medicinal ingredient being added its 2 times of weight makes the watered pill, must treat vitiligo medicinal preparation for oral administration, gained medicinal ingredient be added the vaseline of its 1.2 times of weight, mix homogeneously, must treat leukodermic external and smear unguentum.
Claims (5)
1. treat a leukodermic Chinese medicine, it is characterized in that: comprise the water decoction extract 50-70 weight portion of Herba Swertiae bimaculatae, the alcoholic solution extract 20-40 weight portion of Herba Equiseti Arvinsis, Ramulus Sambuci Williamsii seed oil 3-8 weight portion, excipient right amount of auxiliary materials.
2. the leukodermic Chinese medicine for the treatment of according to claim 1, is characterized in that: comprise water decoction extract 60 weight portion of Herba Swertiae bimaculatae, alcoholic solution extract 30 weight portion of Herba Equiseti Arvinsis, Ramulus Sambuci Williamsii seed oil 5 weight portions.
3. the leukodermic Chinese medicine for the treatment of according to claim 1, is characterized in that: wherein, and the excipient adjuvant of oral agents is starch or Radix Angelicae Dahuricae powder; The excipient adjuvant of outer varnish is vaseline; The consumption of starch or Radix Angelicae Dahuricae powder is 1-1.5 times of extract gross weight; Vaseline consumption is 1.5-2.5 times of extract gross weight.
4. treat a preparation method for vitiligo Chinese medicine described in claim 1, comprise the steps:
(1) Herba Swertiae bimaculatae decocts with water extraction, and the Aqueous extracts after slagging-off is concentrated, dry, pulverize medicated powder is for subsequent use;
(2) Herba Equiseti Arvinsis adds the warm soak extraction of ethanol water, and concentrated extracting solution after slagging-off also reclaims ethanol, and extract dry, pulverize medicated powder is for subsequent use;
(3) get Ramulus Sambuci Williamsii seed, first soak except the composition in sarcocarp with ethanol water, then pull Ramulus Sambuci Williamsii seed out and dry, smash into coarse powder to pieces, gained coarse powder is added ethanol water soak extraction again and go out Ramulus Sambuci Williamsii seed oil;
(4) get step (1) gained Herba Swertiae bimaculatae water extract powder 50-70 weight portion, the alcoholic solution extract powder 20-40 weight portion of step (2) gained Herba Equiseti Arvinsis, the mixing of step (3) gained Ramulus Sambuci Williamsii seed oil 3-8 weight portion, the medicinal ingredient of leukodermic Chinese medicine must be treated;
(5) traditional oral form of Chinese drug is made after step (4) gained medicinal ingredient being added the mixing of appropriate oral agents excipient adjuvant, vitiligo medicinal preparation for oral administration must be treated, or step (4) gained medicinal ingredient is added appropriate external become cream excipient adjuvant, mix homogeneously, must treat leukodermic external and smear unguentum.
5. the preparation method for the treatment of vitiligo Chinese medicine according to claim 4, is characterized in that:
In step (1), Herba Swertiae bimaculatae amount of water is 4-6 times of Herba Swertiae bimaculatae weight; Decoction method decocts 2-3 hour for boiling rear slow fire;
In step (2), it is 40-70% that Herba Equiseti Arvinsis ethanol water extracts added concentration of alcohol (volume ratio), Extracting temperature 40-60 DEG C, soak extraction time 4-6 hour;
In step (3), Ramulus Sambuci Williamsii seed is except forming process in sarcocarp, added ethanol water concentration is 30-60%, soak time 4-8 days, Ramulus Sambuci Williamsii seed oil process is extracted with Ramulus Sambuci Williamsii coarse powder, added ethanol water concentration is 30-60%, and ethanol water addition was as the criterion not have (upper surface that liquid level is piled up higher than medicated powder);
In step (5), peroral dosage form adjuvant is starch or Radix Angelicae Dahuricae powder, starch addition be the 1-1.5 of medicinal ingredient weight doubly;
Radix Angelicae Dahuricae powder addition is 1-1.5 times of medicinal ingredient weight. outer paste excipient adjuvant is vaseline, and vaseline addition is 1.5-2.5 times of medicinal ingredient weight.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693574A (en) * | 2017-10-23 | 2018-02-16 | 刘仁春 | A kind of Chinese medicine and preparation method for treating leucoderma |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005002056A (en) * | 2003-06-12 | 2005-01-06 | Pola Chem Ind Inc | Dendrite growth promoter of melanocyte, and cosmetic containing the same |
| RS62604A (en) * | 2004-07-13 | 2007-08-03 | Milorad Blečić | Herbal preparation having wide range of effect |
-
2015
- 2015-11-30 CN CN201510850685.3A patent/CN105326899A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005002056A (en) * | 2003-06-12 | 2005-01-06 | Pola Chem Ind Inc | Dendrite growth promoter of melanocyte, and cosmetic containing the same |
| RS62604A (en) * | 2004-07-13 | 2007-08-03 | Milorad Blečić | Herbal preparation having wide range of effect |
Non-Patent Citations (1)
| Title |
|---|
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693574A (en) * | 2017-10-23 | 2018-02-16 | 刘仁春 | A kind of Chinese medicine and preparation method for treating leucoderma |
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