CN107468998A - A kind of Chinese hawthorn blood-pressure-reducing dip and preparation method thereof - Google Patents
A kind of Chinese hawthorn blood-pressure-reducing dip and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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Abstract
The invention discloses a kind of Chinese hawthorn blood-pressure-reducing dip, and it is made up of the herbal raw material of following parts by weight:25~35 parts of hawthorn, 20~30 parts of cassia seed, 10~20 parts of rhizoma alismatis, 10~20 parts of giant knotweed, 10~15 parts of myrrh, 5~10 parts of Ligusticum wallichii, 15~25 parts of rheum officinale, 9~16 parts of radix stellariae dichotomae, 15~25 parts of 5~10 parts of HERBA EPIMEDII, 10~15 parts of Ramulus euonymi, 15~25 parts of the bark of ash and turmeric.The invention also discloses the preparation method of Chinese hawthorn blood-pressure-reducing dip, by raw material crush enzymolysis, microbial fermentation, ultrasonic assistant flooding and ultrasonic assistant alcohol extract based on want step to be made.Herbal raw material source of the present invention is wide, and cheap, scientific formulation is reasonable, and preparation technology is simple, and extraction Chinese herbal medicine functional components are high, and product safety environmental protection, without any side effects to human body, promoting blood circulation antihypertensive effect is notable.
Description
Technical field
The invention discloses a kind of dip, more particularly to a kind of Chinese hawthorn blood-pressure-reducing dip and preparation method thereof, belongs to the traditional Chinese medical science
The field of Chinese medicines.
Background technology
With the development of modern society and the improvement of people's living standard, the diet nutrition of people improves constantly, but
The irrational problem of trophic structure be present more, cause current China hypertensive patient increasing.Nearest one of health ministry
Investigation result discloses the serious conditions of high blood pressure illness rate:Compared with before more than ten years, on China's Prevalence of Hypertension is obvious
Rise, with this disease 35~74 years old age bracket Prevalence of Hypertension occurred frequently.Hypertension is based on one kind is persistently raised with arterial pressure
One of the chronic disease to be showed, principal pathogenetic reason is due to human peripheral arteriolar spasm, hinders human peripheral parteriole
Power increases, and so as to cause blood pressure to increase, forms hypertension, often causes the lesion of the vitals such as the heart, brain, kidney and occurs corresponding
Consequence.Long-term hypertension can trigger angiocardiopathy such as miocardial infarction, coronary heart disease etc., may further result in renal arteriosclerosis, from
And cause renal insufficiency, uremia etc..
At present, the treatment to hypertension is most of or relies on western medicine, though Western medicine can meet that in general decompression requires,
But also there is obvious side effect.Because Western medicine decompression is all to expand based on blood vessel, and blood vessel is hit by a bullet in continuous process of expansion
Property dies down and hardened, hence in so that the people of long-term use of depressor easily causes vascular sclerosis and rupture, and causes cerebrovascular bolt
The diseases such as plug, apoplexy.Therefore, Western medicine is not suitable for permanent use.Treatment by Chinese herbs method have act on it is relatively mild, work it is lasting
Feature, the Chinese medicine function active ingredient of generally existing extraction at present is low, prepares and use is more inconvenient, take middle medicine to taste
Liver also has stimulation and infringement.Therefore, the challenge that medical field faces has been turned into how to effectively control hypertension,
Dipping has original effect to human body, with a history of thousands of years in China, is paid attention to always by medical field since ancient times.Medicine
Bath method is one of external therapy, and its form is varied.The dipping mechanism of action in brief, medicine act on whole body fleshy exterior, part,
Affected part, and through absorbing, circulation channels and collaterals blood vessels are interior to reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, dredging can be played
Channels and collaterals, activate blood circulation and disperse blood clots, wind dispelling cold dispelling, clearing heat and detoxicating, swelling and pain relieving, adjustment negative and positive, coordinate internal organs, current qi and blood, moisten foster whole body
Etc. health maintenance effect.Dipping avoids stimulation of the medicine to taste and the infringement to liver, effective ingredient is inhaled by skin
Receive and play effect, be the Perfected process of the various chronic diseases of preventing and treating and health care.
Chinese herbal medicine is the rarity of Chinese traditional culture, proves that a variety of Chinese herbal medicines have in practice and enhances metabolism, changes
Kind blood circulation, improving eyesight are reduced internal heat, The flat liver of heat-clearing, promoting blood circulation decompression, diuretic antihypertensive and other effects, therefore, Chinese herbal medicine are applied into treatment
Hypertension ensures that living safety tool is of great significance, but Chinese herbal treatment is high at present for improving national life quality
Blood pressure dipping not yet realizes scale and industrialization in application, and subject matter is that Chinese herbal medicine compatibility is unreasonable, functional component extraction
The drawbacks such as rate is low, be difficult to industrialized production, effect is not notable, therefore developing new hypotensor bathroom facilities has important reality to anticipate
Justice.
The content of the invention
It is an object of the invention to the above mentioned problem according to existing for existing treatment hypertension product and technology, a kind of mountain is developed
Short, bristly hair or beard is depressured dip, people is passed through dipping to promote body metabolism, improves body blood circulation, and improving eyesight is reduced internal heat, heat-clearing
Soothing the liver, promoting blood circulation decompression, diuretic antihypertensive, dispels the cause of disease from root, allows puzzlement of the people away from hypertension.
To achieve these goals, the present invention uses following technical scheme:
A kind of Chinese hawthorn blood-pressure-reducing dip, is made up of the herbal raw material of following parts by weight:25~35 parts of hawthorn, cassia seed 20~30
Part, 10~20 parts of rhizoma alismatis, 10~20 parts of giant knotweed, 10~15 parts of myrrh, 5~10 parts of Ligusticum wallichii, 15~25 parts of rheum officinale, radix stellariae dichotomae 9~
16 parts, 5~10 parts of HERBA EPIMEDII, 10~15 parts of Ramulus euonymi, 15~25 parts of 15~25 parts of the bark of ash and turmeric.
The preparation method of Chinese hawthorn blood-pressure-reducing dip of the present invention, comprises the following steps:
(1)Stock:The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion;
(2)Feedstock treating:Herbal raw material is cleaned up, at 70~80 DEG C, after air blast drying, pulverizer crushes, and crosses 50
~100 mesh sieves, mix, obtain composite Chinese herbal raw material;
(3)Enzymolysis:By step(2)Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1:3~5, by 2.0~3.0 g/L, 2.0
~3.0 g/L, 2~4 g/L ratios add non-starch polysaccharide enzyme, carbohydrase, cellulase respectively, in 600 ~ 1000 W ultrasonic waves
Under booster action, the min of coordinated enzymatic hydrolysis 60~90 under the conditions of 40~50 DEG C;
(4)Microbial fermentation:To step(3)The Bifidobacterium added in gained Enzymolysis liquid after 3~5% activation(Viable count >=
20000000000/ml), ferment under anaerobic condition 18~24 h, controls 28~35 DEG C of fermentation temperature;
(5)Ultrasonic assistant flooding:By step(4)Microbial fermentation mixed liquor, 85~95 DEG C are warmed to, 600 ~ 1000
Under the effect of W ultrasonic assistants, 60 ~ 90 min are extracted, after extraction terminates, 150 ~ 200 mesh filter clothes is crossed and obtains water extract.Filter residue adds 2 ~
4 times of pure water, carry out Ultrasonic Wave-Assisted Extraction, filter to get filtrate in the same way, and it is water extract to merge extract solution twice;
(6)Ultrasonic assistant alcohol steep:To step(5)The ethanol that 3~6 times of concentration are 50~60% is added in gained filter residue,
Under the conditions of 600~900 W ultrasonic assistants, 120~180 min, 50~60 DEG C of extraction temperature are extracted;
(7)Centrifugation:Extraction centrifuges solid residue and alcohol extract after terminating;
(8)Concentration distillation:Alcohol extract is concentrated under reduced pressure and is distilled to recover ethanol;
(9)Mixing:By step(5)Water extract and step(8)Reclaim the leaching liquor mixing after ethanol;
(10)Filtering:Mixed liquor is filtered to remove impurity and insoluble matter therein through diatom filter and produces Chinese hawthorn blood-pressure-reducing dipping
Liquid.
The present invention provides a kind of Chinese hawthorn blood-pressure-reducing dip, and the characteristic of each Chinese herbal medicine, is managed using Chinese medical discrimination in combined formulation
By being developed, scientific formulation is reasonable, is acted synergistically between each component, proves that there is the present invention good promoting blood circulation to be depressured by long-term use
Effect.Advantage of the invention is that:(1)Product is not required to, by body absorption, drug effect be directly acted on using medicine during dipping
Affected part, safety and environmental protection, mild in medicine property and, it is without any side effects to human body;(2)Product has pleasant Chinese herbal medicine delicate fragrance, using just
Victory, this product need to be only taken by 1 during use:400~600 ratios are called in heating bath water, can carry out immersion bathing;(3)With dipping
Powder merely compare by addition, and compared with medical bathing powder adds merely, the present invention crushes enzymolysis, microbial fermentation, ultrasonic wave using raw material
Preparation process is wanted based on auxiliary flooding and the extraction of ultrasonic assistant alcohol, improves Chinese herbal medicine functional components, antihypertensive effect of invigorating blood circulation
Significantly;(4)Raw material sources are wide in the present invention, cheap, and production and processing technology is simple, are adapted to large-scale production.
Embodiment
Below by embodiment, the present invention will be further described.In the present invention, if not refering in particular to, Suo Youbai
Point ratio is unit of weight, and all devices and raw material are commercially available or the industry is commonly used, in following embodiments
Method, it is this area conventional method unless otherwise instructed.
Embodiment 1
A kind of Chinese hawthorn blood-pressure-reducing dip, is made up of the herbal raw material of following each component:Hawthorn, cassia seed, rhizoma alismatis, giant knotweed, do not have
Medicine, Ligusticum wallichii, rheum officinale, radix stellariae dichotomae, HERBA EPIMEDII, Ramulus euonymi, the bark of ash and turmeric.The specific of each component matches somebody with somebody such as table in herbal raw material
Shown in 1.
The preparation method of Chinese hawthorn blood-pressure-reducing dip of the present invention, comprises the following steps:
(1)Stock:The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion;
(2)Feedstock treating:Herbal raw material is cleaned up, at 80 DEG C, after air blast drying, pulverizer crushes, and crosses 60 mesh
Sieve, mix, obtain composite Chinese herbal raw material;
(3)Enzymolysis:By step(2)Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1:4, by 2.0 g/L, 2.8 g/L, 2.5
G/L ratios add non-starch polysaccharide enzyme, carbohydrase, cellulase respectively, under the effect of 800 W ultrasonic assistants, in 42 DEG C of bars
The min of coordinated enzymatic hydrolysis 75 under part;
(4)Microbial fermentation:To step(3)The Bifidobacterium added in gained Enzymolysis liquid after 3% activation(Viable count >=200
Hundred million/ml), ferment under anaerobic condition 22 h, controls 30 DEG C of fermentation temperature;
(5)Ultrasonic assistant flooding:By step(4)Microbial fermentation mixed liquor, 86 DEG C are warmed to, it is auxiliary in 900 W ultrasonic waves
Help under effect, extract 80 min, after extraction terminates, cross 160 mesh filter clothes and obtain water extract.Filter residue adds 3 times of pure water, by same sample prescription
Method carries out Ultrasonic Wave-Assisted Extraction, filters to get filtrate, and it is water extract to merge extract solution twice;
(6)Ultrasonic assistant alcohol steep:To step(5)The ethanol that 5 times of concentration are 52% is added in gained filter residue, in 850 W
Under the conditions of ultrasonic assistant, 120 min, 60 DEG C of extraction temperature are extracted;
(7)Centrifugation:Extraction centrifuges solid residue and alcohol extract after terminating;
(8)Concentration distillation:Alcohol extract is concentrated under reduced pressure and is distilled to recover ethanol;
(9)Mixing:By step(5)Water extract and step(8)Reclaim the leaching liquor mixing after ethanol;
(10)Filtering:Mixed liquor is filtered to remove impurity and insoluble matter therein through diatom filter and produces Chinese hawthorn blood-pressure-reducing dipping
Liquid.
Embodiment 2
A kind of Chinese hawthorn blood-pressure-reducing dip, is made up of the herbal raw material of following each component:Hawthorn, cassia seed, rhizoma alismatis, giant knotweed, do not have
Medicine, Ligusticum wallichii, rheum officinale, radix stellariae dichotomae, HERBA EPIMEDII, Ramulus euonymi, the bark of ash and turmeric.The specific of each component matches somebody with somebody such as table in herbal raw material
Shown in 1.
The preparation method of Chinese hawthorn blood-pressure-reducing dip of the present invention, comprises the following steps:
(1)Stock:The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion;
(2)Feedstock treating:Herbal raw material is cleaned up, at 72 DEG C, after air blast drying, pulverizer crushes, and crosses 80 mesh
Sieve, mix, obtain composite Chinese herbal raw material;
(3)Enzymolysis:By step(2)Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1:3, by 2.4 g/L, 2.2 g/L, 2.5
G/L ratios add non-starch polysaccharide enzyme, carbohydrase, cellulase respectively, under the effect of 700 W ultrasonic assistants, in 48 DEG C of bars
The min of coordinated enzymatic hydrolysis 80 under part;
(4)Microbial fermentation:To step(3)The Bifidobacterium added in gained Enzymolysis liquid after 4% activation(Viable count >=200
Hundred million/ml), ferment under anaerobic condition 20 h, controls 32 DEG C of fermentation temperature;
(5)Ultrasonic assistant flooding:By step(4)Microbial fermentation mixed liquor, 90 DEG C are warmed to, it is auxiliary in 800 W ultrasonic waves
Help under effect, extract 85 min, after extraction terminates, cross 180 mesh filter clothes and obtain water extract.Filter residue adds 2 times of pure water, by same sample prescription
Method carries out Ultrasonic Wave-Assisted Extraction, filters to get filtrate, and it is water extract to merge extract solution twice;
(6)Ultrasonic assistant alcohol steep:To step(5)The ethanol that 4 times of concentration are 58% is added in gained filter residue, in 850 W
Under the conditions of ultrasonic assistant, 150 min, 55 DEG C of extraction temperature are extracted;
(7)Centrifugation:Extraction centrifuges solid residue and alcohol extract after terminating;
(8)Concentration distillation:Alcohol extract is concentrated under reduced pressure and is distilled to recover ethanol;
(9)Mixing:By step(5)Water extract and step(8)Reclaim the leaching liquor mixing after ethanol;
(10)Filtering:Mixed liquor is filtered to remove impurity and insoluble matter therein through diatom filter and produces Chinese hawthorn blood-pressure-reducing dipping
Liquid.
Embodiment 3
A kind of Chinese hawthorn blood-pressure-reducing dip, is made up of the herbal raw material of following each component:Hawthorn, cassia seed, rhizoma alismatis, giant knotweed, do not have
Medicine, Ligusticum wallichii, rheum officinale, radix stellariae dichotomae, HERBA EPIMEDII, Ramulus euonymi, the bark of ash and turmeric.The specific of each component matches somebody with somebody such as table in herbal raw material
Shown in 1.
The preparation method of Chinese hawthorn blood-pressure-reducing dip of the present invention, comprises the following steps:
(1)Stock:The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion;
(2)Feedstock treating:Herbal raw material is cleaned up, at 72 DEG C, after air blast drying, pulverizer crushes, and crosses 100 mesh
Sieve, mix, obtain composite Chinese herbal raw material;
(3)Enzymolysis:By step(2)Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1:5, by 2.8 g/L, 2.4 g/L, 3.5
G/L ratios add non-starch polysaccharide enzyme, carbohydrase, cellulase respectively, under the effect of 900 W ultrasonic assistants, in 45 DEG C of bars
The min of coordinated enzymatic hydrolysis 85 under part;
(4)Microbial fermentation:To step(3)The Bifidobacterium added in gained Enzymolysis liquid after 5% activation(Viable count >=200
Hundred million/ml), ferment under anaerobic condition 19 h, controls 34 DEG C of fermentation temperature;
(5)Ultrasonic assistant flooding:By step(4)Microbial fermentation mixed liquor, 94 DEG C are warmed to, it is auxiliary in 700 W ultrasonic waves
Help under effect, extract 75 min, after extraction terminates, cross 200 mesh filter clothes and obtain water extract.Filter residue adds 4 times of pure water, by same sample prescription
Method carries out Ultrasonic Wave-Assisted Extraction, filters to get filtrate, and it is water extract to merge extract solution twice;
(6)Ultrasonic assistant alcohol steep:To step(5)The ethanol that 6 times of concentration are 54% is added in gained filter residue, in 650 W
Under the conditions of ultrasonic assistant, 125 min, 50 DEG C of extraction temperature are extracted;
(7)Centrifugation:Extraction centrifuges solid residue and alcohol extract after terminating;
(8)Concentration distillation:Alcohol extract is concentrated under reduced pressure and is distilled to recover ethanol;
(9)Mixing:By step(5)Water extract and step(8)Reclaim the leaching liquor mixing after ethanol;
(10)Filtering:Mixed liquor is filtered to remove impurity and insoluble matter therein through diatom filter and produces Chinese hawthorn blood-pressure-reducing dipping
Liquid.
The composition and ratio of each embodiment herbal raw material of table 1.
Sequence number | Component | Embodiment 1 | Embodiment 2 | Embodiment 3 |
1 | Hawthorn(Part) | 30 | 34 | 26 |
2 | Cassia seed(Part) | 24 | 21 | 27 |
3 | Rhizoma alismatis(Part) | 14 | 18 | 11 |
4 | Giant knotweed(Part) | 18 | 15 | 12 |
5 | Myrrh(Part) | 11 | 13 | 15 |
6 | Ligusticum wallichii(Part) | 6 | 9 | 7 |
7 | Rheum officinale(Part) | 19 | 17 | 23 |
8 | Radix stellariae dichotomae(Part) | 11 | 13 | 15 |
9 | HERBA EPIMEDII(Part) | 6 | 7 | 9 |
10 | Ramulus euonymi(Part) | 12 | 13 | 14 |
11 | The bark of ash(Part) | 21 | 23 | 17 |
12 | Turmeric(Part) | 19 | 23 | 21 |
13 | Summation(Part) | 191 | 206 | 197 |
Although to reach illustration purpose, described above is the preferred embodiments of the present invention, is not intended to limit the invention, to the greatest extent
The present invention is described in detail with reference to the foregoing embodiments for pipe, and for those skilled in the art, it still can be with
The technical scheme recorded to foregoing embodiments is modified, or carries out equivalent substitution to which part technical characteristic.It is all
Within the spirit and principles in the present invention, any modification, equivalent substitution and improvements made etc., the protection of the present invention should be included in
Within the scope of.
Claims (2)
1. a kind of Chinese hawthorn blood-pressure-reducing dip, it is characterised in that be made up of the herbal raw material by following parts by weight:Hawthorn 25~35
Part, 20~30 parts of cassia seed, 10~20 parts of rhizoma alismatis, 10~20 parts of giant knotweed, 10~15 parts of myrrh, 5~10 parts of Ligusticum wallichii, rheum officinale 15~
25 parts, 9~16 parts of radix stellariae dichotomae, 5~10 parts of HERBA EPIMEDII, 10~15 parts of Ramulus euonymi, 15~25 parts of 15~25 parts of the bark of ash and turmeric.
2. a kind of preparation method of Chinese hawthorn blood-pressure-reducing dip as claimed in claim 1, it is characterised in that comprise the following steps:
(1)Stock:The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion;
(2)Feedstock treating:Herbal raw material is cleaned up, at 70~80 DEG C, after air blast drying, pulverizer crushes, and crosses 50
~100 mesh sieves, mix, obtain composite Chinese herbal raw material;
(3)Enzymolysis:By step(2)Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1:3~5, by 2.0~3.0 g/L, 2.0
~3.0 g/L, 2~4 g/L ratios add non-starch polysaccharide enzyme, carbohydrase, cellulase respectively, in 600 ~ 1000 W ultrasonic waves
Under booster action, the min of coordinated enzymatic hydrolysis 60~90 under the conditions of 40~50 DEG C;
(4)Microbial fermentation:To step(3)The Bifidobacterium added in gained Enzymolysis liquid after 3~5% activation(Viable count >=
20000000000/ml), ferment under anaerobic condition 18~24 h, controls 28~35 DEG C of fermentation temperature;
(5)Ultrasonic assistant flooding:By step(4)Microbial fermentation mixed liquor, 85~95 DEG C are warmed to, 600 ~ 1000
Under the effect of W ultrasonic assistants, 60 ~ 90 min are extracted, after extraction terminates, 150 ~ 200 mesh filter clothes is crossed and obtains water extract;Filter residue adds 2 ~
4 times of pure water, carry out Ultrasonic Wave-Assisted Extraction, filter to get filtrate in the same way, and it is water extract to merge extract solution twice;
(6)Ultrasonic assistant alcohol steep:To step(5)The ethanol that 3~6 times of concentration are 50~60% is added in gained filter residue,
Under the conditions of 600~900 W ultrasonic assistants, 120~180 min, 50~60 DEG C of extraction temperature are extracted;
(7)Centrifugation:Extraction centrifuges solid residue and alcohol extract after terminating;
(8)Concentration distillation:Alcohol extract is concentrated under reduced pressure and is distilled to recover ethanol;
(9)Mixing:By step(5)Water extract and step(8)Reclaim the leaching liquor mixing after ethanol;
(10)Filtering:Mixed liquor is filtered to remove impurity and insoluble matter therein through diatom filter and produces Chinese hawthorn blood-pressure-reducing dipping
Liquid.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT201800003917A1 (en) * | 2018-03-26 | 2019-09-26 | Neilos S R L | Composition for the reduction of plasma levels of uric acid. |
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2017
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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IT201800003917A1 (en) * | 2018-03-26 | 2019-09-26 | Neilos S R L | Composition for the reduction of plasma levels of uric acid. |
EP3545947A1 (en) * | 2018-03-26 | 2019-10-02 | Neilos S.r.l. | Composition for the reduction of plasma levels of uric acid |
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