CN107441427A - One kind preventing and treating alopecia tuber of multiflower knotweed cloves dip and preparation method thereof - Google Patents
One kind preventing and treating alopecia tuber of multiflower knotweed cloves dip and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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Abstract
The invention discloses one kind to prevent and treat alopecia tuber of multiflower knotweed cloves dip, and it is made up of the herbal raw material of following parts by weight：10~15 parts of 15~20 parts of the tuber of multiflower knotweed, 8~12 parts of cloves, 10~16 parts of santal, 4~8 parts of rose, 10~20 parts of the flower bud of lily magnolia, 12~16 parts of asarum, 10~15 parts of kaempferia galamga, 10~20 parts of the root of Dahurain angelica, 5~8 parts of radix glycyrrhizae and the fruit of glossy privet.The invention also discloses the preparation method of preventing and treating alopecia tuber of multiflower knotweed cloves dip, crushes enzymolysis, microbial fermentation by raw material, ultrasonic wave adverse current is extracted, is concentrated under reduced pressure and is filtered into key step and be made.Herbal raw material source of the present invention is wide, and cheap, scientific formulation is reasonable, and preparation technology is simple, and extraction Chinese herbal medicine functional components are high, and product safety environmental protection is without any side effects to human body, prevents and treats alopecia significant effect.
Description
Technical field
The invention discloses a kind of dip, more particularly to a kind of preventing and treating alopecia tuber of multiflower knotweed cloves dip and its preparation side
Method, belong to traditional Chinese medicine field.
Background technology
Epilation is a kind of common disease, and reason is a lot, has the factors such as blood wind, Drug, anaemia, malnutrition to be made
Into alopecia, such as malpractice or not in time, hair can be made to come off for a long time even whole de- light, have a strong impact on people life,
Study, work or even physical and mental health.In terms of hair growth, existing preventing and treating alopecia agent species is various, but Anti-hair loss production at present
Product are primarily present following defect：1st, product price is expensive, Anti-hair loss effect is poor, and has larger side effect；2nd, to many reasons
Caused alopecia has certain effect, but the course for the treatment of is oversize, and hair-growing effects are bad.
Dipping has original effect to human body, with a history of thousands of years in China, since ancient times always by medical field weight
Depending on.Dipping method is one of external therapy, i.e., a variety of with decoction or a kind of method containing decoction water washing bath whole body or part, its form
It is various.In brief, medicine acts on whole body fleshy exterior, part, affected part to the dipping mechanism of action, and through absorbing, circulation channels and collaterals blood vessels,
It is interior to reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the channel, activate blood circulation and disperse blood clots, wind dispelling cold dispelling, heat-clearing
Removing toxic substances, swelling and pain relieving, negative and positive are adjusted, coordinates internal organs, current qi and blood, moisten the health maintenance effects such as foster whole body.Dipping avoids medicine pair
The stimulation of taste and the infringement to liver, effective ingredient is absorbed by skin to play effect, be that preventing and treating is various chronic
Disease and the Perfected process of health care.
Chinese herbal medicine is the rarity of Chinese traditional culture, proves that a variety of Chinese herbal medicines have in practice and enhances metabolism, changes
Kind blood circulation, except heat, strengthening the spleen and replenishing qi, nourishing yin and supplementing blood, regulation internal organs, preventing and treating alopecia and other effects therefore, should by Chinese herbal medicine for wind-dispelling
For preventing and treating alopecia for improving national life quality, ensure that national physically and mentally healthy tool is of great significance, but at present in
Herbal medicine dipping not yet realizes scale and industrialization in the application of preventing and treating alopecia, complex manufacturing be present, equipment investment is big, gives birth to
The drawbacks such as production cost is high, be difficult to industrialized production, functional component recovery rate is low, effect is poor, therefore develop new preventing and treating alopecia
Dipping has important practical significance.
The content of the invention
It is blood wind, Drug, poor it is an object of the invention to the above mentioned problem according to existing for existing preventing and treating hair-removal products
Hair loss patient caused by the factors such as blood, malnutrition, develops a kind of preventing and treating alopecia tuber of multiflower knotweed cloves dip, and the product passes through head
Portion's dipping promotes body metabolism, improves body blood circulation, wind-dispelling is except heat, clearing heat and detoxicating, invigorating the spleen, QI invigorating, enriching yin, benefit
Blood, regulation organ function, product has short treating period, preventing and treating alopecia significant effect, and has hair-growing effects, is solved from root
The puzzlement of people's alopecia.
To achieve these goals, the present invention uses following technical scheme：
One kind preventing and treating alopecia tuber of multiflower knotweed cloves dip, is made up of the herbal raw material of following parts by weight：15~20 parts of the tuber of multiflower knotweed, cloves
8~12 parts, 10~16 parts of santal, 4~8 parts of rose, 10~20 parts of the flower bud of lily magnolia, 12~16 parts of asarum, 10~15 parts of kaempferia galamga, the root of Dahurain angelica
10~20 parts, 10~15 parts of 5~8 parts of radix glycyrrhizae and the fruit of glossy privet.
The preparation method of present invention preventing and treating alopecia tuber of multiflower knotweed cloves dip, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 60~80 DEG C, after air blast drying, pulverizer crushes, and crosses 40
~80 mesh sieves, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：3~5, by 1.0~1.5 g/L, 2.0
~3.0 g/L ratios add non-starch polysaccharide enzyme, cellulase respectively, under the effect of 500 ~ 800 W ultrasonic assistants, 45~
The min of coordinated enzymatic hydrolysis 40~60 under the conditions of 60 DEG C；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 3~5% activation（Viable count >=
20000000000/ml）, ferment under anaerobic condition 8~12 h, controls 28~35 DEG C of fermentation temperature；
（5）Centrifugation：Solid residue and supernatant are centrifuged after fermentation ends；
（6）Ultrasonic adverse current is extracted：By step（5）Obtained solid residue, 3~5 times of 40~55% ethanol are added, are put into ultrasound
In Continuous Countercurrent Extraction machine, under the effect of 600 ~ 1000 W ultrasonic assistants, after adverse current extracts 30 ~ 60 min, 120 ~ 180 mesh are crossed
Filter cloth obtains extract solution.Filter residue carries out ultrasonic continuous countercurrent and extracted 1 time in the same way, merges extract solution twice；
（7）It is concentrated under reduced pressure：By step（6）The extract solution of gained is at 45~60 DEG C of temperature, vacuum -0.06~-0.085
It is evaporated under reduced pressure under MPa, reclaims the ethanol in extracts of Chinese herbal medicine to without alcohol taste, obtain removing ethanol extracts of Chinese herbal medicine；
（8）Filtering：By step（5）Gained supernatant and step（7）The removal ethanol extracts of Chinese herbal medicine of gained mixes, through diatom
Filter is filtered to remove impurity and insoluble matter therein, produces preventing and treating alopecia tuber of multiflower knotweed cloves dip.
The present invention provides a kind of preventing and treating alopecia tuber of multiflower knotweed cloves dip, the characteristic of each Chinese herbal medicine in combined formulation, in
Cure dialectical theory to be developed, scientific formulation is reasonable, acts synergistically between each component, proves that body can be effectively facilitated by long-term use
Metabolism, improve body blood circulation, wind-dispelling except heat, clearing heat and detoxicating, invigorating the spleen, QI invigorating, enriching yin, enrich blood, adjust organ function,
Alopecia significant effect is prevented and treated, the puzzlement for solving people's alopecia from root.Advantage of the invention is that：（1）Product uses dipping
When medicine be not required to by body absorption, drug effect is directly acted on into affected part, safety and environmental protection, mild in medicine property and, to human body without any pair
Effect；（2）Product has pleasant Chinese herbal medicine delicate fragrance, easy to use, need to only take this product by 1 during use：300~600 ratios
Call in heating bath water, head immersion bathing can be carried out；（3）Compared with medical bathing powder adds merely, the present invention is crushed using raw material
Enzymolysis, microbial fermentation, ultrasonic wave adverse current are extracted, are concentrated under reduced pressure and are filtered into main preparation section, effectively improve Chinese herbal medicine
Functional components, prevent and treat alopecia significant effect；（4）Raw material sources are wide in the present invention, cheap, and production and processing technology is simple,
It is adapted to large-scale production.
Embodiment
Below by embodiment, the present invention will be further described.In the present invention, if not refering in particular to, Suo Youbai
Point ratio is unit of weight, and all devices and raw material are commercially available or the industry is commonly used, in following embodiments
Method, it is this area conventional method unless otherwise instructed.
Embodiment 1
One kind preventing and treating alopecia tuber of multiflower knotweed cloves dip, is made up of the raw material of following each component：The tuber of multiflower knotweed, cloves, santal, rose,
The flower bud of lily magnolia, asarum, kaempferia galamga, the root of Dahurain angelica, radix glycyrrhizae and the fruit of glossy privet.The specific proportioning of each component is as shown in table 1 in herbal raw material.
The preparation method of present invention preventing and treating alopecia tuber of multiflower knotweed cloves dip, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 75 DEG C, after air blast drying, pulverizer crushes, and crosses 50 mesh
Sieve, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：4, in 1.2 g/L, 2.7 g/L ratios
Non-starch polysaccharide enzyme, cellulase are added respectively, under the effect of 600 W ultrasonic assistants, the coordinated enzymatic hydrolysis 50 under the conditions of 60 DEG C
min；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 4% activation（Viable count >=200
Hundred million/ml）, ferment under anaerobic condition 10 h, controls 32 DEG C of fermentation temperature；
（5）Centrifugation：Solid residue and supernatant are centrifuged after fermentation ends；
（6）Ultrasonic adverse current is extracted：By step（5）Obtained solid residue, 3 times of 45% ethanol is added, is put into ultrasonic continuous countercurrent
In extractor, under the effect of 800 W ultrasonic assistants, after adverse current extracts 50 min, cross 160 mesh filter clothes and obtain extract solution.Filter residue is pressed
Same method carries out ultrasonic continuous countercurrent and extracted 1 time, merges extract solution twice；
（7）It is concentrated under reduced pressure：By step（6）The extract solution of gained is depressurized at 48 DEG C of temperature under the MPa of vacuum -0.06
Distillation, the ethanol in extracts of Chinese herbal medicine is reclaimed to without alcohol taste, obtains removing ethanol extracts of Chinese herbal medicine；
（8）Filtering：By step（5）Gained supernatant and step（7）The removal ethanol extracts of Chinese herbal medicine of gained mixes, through diatom
Filter is filtered to remove impurity and insoluble matter therein, produces preventing and treating alopecia tuber of multiflower knotweed cloves dip.
Embodiment 2
One kind preventing and treating alopecia tuber of multiflower knotweed cloves dip, is made up of the raw material of following each component：The tuber of multiflower knotweed, cloves, santal, rose,
The flower bud of lily magnolia, asarum, kaempferia galamga, the root of Dahurain angelica, radix glycyrrhizae and the fruit of glossy privet.The specific proportioning of each component is as shown in table 1 in herbal raw material.
The preparation method of present invention preventing and treating alopecia tuber of multiflower knotweed cloves dip, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 70 DEG C, after air blast drying, pulverizer crushes, and crosses 60 mesh
Sieve, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：3, in 1.4 g/L, 2.5 g/L ratios
Non-starch polysaccharide enzyme, cellulase are added respectively, under the effect of 700 W ultrasonic assistants, the coordinated enzymatic hydrolysis 45 under the conditions of 55 DEG C
min；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 3% activation（Viable count >=200
Hundred million/ml）, ferment under anaerobic condition 9 h, controls 30 DEG C of fermentation temperature；
（5）Centrifugation：Solid residue and supernatant are centrifuged after fermentation ends；
（6）Ultrasonic adverse current is extracted：By step（5）Obtained solid residue, 4 times of 48% ethanol is added, is put into ultrasonic continuous countercurrent
In extractor, under the effect of 900 W ultrasonic assistants, after adverse current extracts 40 min, cross 150 mesh filter clothes and obtain extract solution.Filter residue is pressed
Same method carries out ultrasonic continuous countercurrent and extracted 1 time, merges extract solution twice；
（7）It is concentrated under reduced pressure：By step（6）The extract solution of gained is depressurized at 52 DEG C of temperature under the MPa of vacuum -0.07
Distillation, the ethanol in extracts of Chinese herbal medicine is reclaimed to without alcohol taste, obtains removing ethanol extracts of Chinese herbal medicine；
（8）Filtering：By step（5）Gained supernatant and step（7）The removal ethanol extracts of Chinese herbal medicine of gained mixes, through diatom
Filter is filtered to remove impurity and insoluble matter therein, produces preventing and treating alopecia tuber of multiflower knotweed cloves dip.
Embodiment 3
One kind preventing and treating alopecia tuber of multiflower knotweed cloves dip, is made up of the raw material of following each component：The tuber of multiflower knotweed, cloves, santal, rose,
The flower bud of lily magnolia, asarum, kaempferia galamga, the root of Dahurain angelica, radix glycyrrhizae and the fruit of glossy privet.The specific proportioning of each component is as shown in table 1 in herbal raw material.
The preparation method of present invention preventing and treating alopecia tuber of multiflower knotweed cloves dip, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 65 DEG C, after air blast drying, pulverizer crushes, and crosses 70 mesh
Sieve, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：5, in 1.1 g/L, 2.3 g/L ratios
Non-starch polysaccharide enzyme, cellulase are added respectively, under the effect of 650 W ultrasonic assistants, the coordinated enzymatic hydrolysis 55 under the conditions of 50 DEG C
min；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 5% activation（Viable count >=200
Hundred million/ml）, ferment under anaerobic condition 11 h, controls 35 DEG C of fermentation temperature；
（5）Centrifugation：Solid residue and supernatant are centrifuged after fermentation ends；
（6）Ultrasonic adverse current is extracted：By step（5）Obtained solid residue, 5 times of 52% ethanol is added, is put into ultrasonic continuous countercurrent
In extractor, under the effect of 700 W ultrasonic assistants, after adverse current extracts 45 min, cross 120 mesh filter clothes and obtain extract solution.Filter residue is pressed
Same method carries out ultrasonic continuous countercurrent and extracted 1 time, merges extract solution twice；
（7）It is concentrated under reduced pressure：By step（6）The extract solution of gained is depressurized at 56 DEG C of temperature under the MPa of vacuum -0.08
Distillation, the ethanol in extracts of Chinese herbal medicine is reclaimed to without alcohol taste, obtains removing ethanol extracts of Chinese herbal medicine；
（8）Filtering：By step（5）Gained supernatant and step（7）The removal ethanol extracts of Chinese herbal medicine of gained mixes, through diatom
Filter is filtered to remove impurity and insoluble matter therein, produces preventing and treating alopecia tuber of multiflower knotweed cloves dip.
The composition and ratio of each embodiment herbal raw material of table 1.
| Sequence number | Component | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| 1 | The tuber of multiflower knotweed（Part） | 16 | 17 | 19 |
| 2 | Cloves（Part） | 11 | 9 | 8 |
| 3 | Santal（Part） | 12 | 11 | 14 |
| 4 | Rose（Part） | 5 | 7 | 6 |
| 5 | The flower bud of lily magnolia（Part） | 13 | 18 | 16 |
| 6 | Asarum（Part） | 13 | 14 | 15 |
| 7 | Kaempferia galamga（Part） | 13 | 12 | 11 |
| 8 | The root of Dahurain angelica（Part） | 16 | 18 | 11 |
| 9 | Radix glycyrrhizae（Part） | 5 | 7 | 6 |
| 10 | The fruit of glossy privet（Part） | 13 | 11 | 14 |
| 11 | Summation（Part） | 117 | 124 | 120 |
Although to reach illustration purpose, described above is the preferred embodiments of the present invention, is not intended to limit the invention, to the greatest extent
The present invention is described in detail with reference to the foregoing embodiments for pipe, and for those skilled in the art, it still can be with
The technical scheme recorded to foregoing embodiments is modified, or carries out equivalent substitution to which part technical characteristic.It is all
Within the spirit and principles in the present invention, any modification, equivalent substitution and improvements made etc., the protection of the present invention should be included in
Within the scope of.
Claims (3)
1. one kind preventing and treating alopecia tuber of multiflower knotweed cloves dip, it is characterised in that be made up of following herbal raw material by weight：It is first
15~20 parts of crow, 8~12 parts of cloves, 10~16 parts of santal, 4~8 parts of rose, 10~20 parts of the flower bud of lily magnolia, 12~16 parts of asarum, mountain
How 10~15 parts, 10~20 parts of the root of Dahurain angelica, 10~15 parts of 5~8 parts of radix glycyrrhizae and the fruit of glossy privet.
A kind of 2. preparation method of preventing and treating alopecia tuber of multiflower knotweed cloves dip as claimed in claim 1, it is characterised in that including with
Lower step：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 60~80 DEG C, after air blast drying, pulverizer crushes, and crosses 40
~80 mesh sieves, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：3~5, by 1.0~1.5 g/L, 2.0
~3.0 g/L ratios add non-starch polysaccharide enzyme, cellulase respectively, under the effect of 500 ~ 800 W ultrasonic assistants, 45~
The min of coordinated enzymatic hydrolysis 40~60 under the conditions of 60 DEG C；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 3~5% activation（Viable count >=
20000000000/ml）, ferment under anaerobic condition 8~12 h, controls 28~35 DEG C of fermentation temperature；
（5）Centrifugation：Solid residue and supernatant are centrifuged after fermentation ends；
（6）Ultrasonic adverse current is extracted：By step（5）Obtained solid residue, 3~5 times of 40~55% ethanol are added, are put into ultrasound
In Continuous Countercurrent Extraction machine, under the effect of 600 ~ 1000 W ultrasonic assistants, after adverse current extracts 30 ~ 60 min, 120 ~ 180 mesh are crossed
Filter cloth obtains extract solution.
Extracted 1 time 3. filter residue carries out ultrasonic continuous countercurrent in the same way, merge extract solution twice；
（7）It is concentrated under reduced pressure：By step（6）The extract solution of gained is at 45~60 DEG C of temperature, vacuum -0.06~-0.085
It is evaporated under reduced pressure under MPa, reclaims the ethanol in extracts of Chinese herbal medicine to without alcohol taste, obtain removing ethanol extracts of Chinese herbal medicine；
（8）Filtering：By step（5）Gained supernatant and step（7）The removal ethanol extracts of Chinese herbal medicine of gained mixes, through diatom
Filter is filtered to remove impurity and insoluble matter therein, produces preventing and treating alopecia tuber of multiflower knotweed cloves dip.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710727742.8A CN107441427A (en) | 2017-08-23 | 2017-08-23 | One kind preventing and treating alopecia tuber of multiflower knotweed cloves dip and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710727742.8A CN107441427A (en) | 2017-08-23 | 2017-08-23 | One kind preventing and treating alopecia tuber of multiflower knotweed cloves dip and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107441427A true CN107441427A (en) | 2017-12-08 |
Family
ID=60493761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710727742.8A Pending CN107441427A (en) | 2017-08-23 | 2017-08-23 | One kind preventing and treating alopecia tuber of multiflower knotweed cloves dip and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107441427A (en) |
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2017
- 2017-08-23 CN CN201710727742.8A patent/CN107441427A/en active Pending
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Application publication date: 20171208 |