CN103055096A - Application for freeze-dried Chinese yam in medicine preparation - Google Patents

Application for freeze-dried Chinese yam in medicine preparation Download PDF

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CN103055096A
CN103055096A CN201310008646XA CN201310008646A CN103055096A CN 103055096 A CN103055096 A CN 103055096A CN 201310008646X A CN201310008646X A CN 201310008646XA CN 201310008646 A CN201310008646 A CN 201310008646A CN 103055096 A CN103055096 A CN 103055096A
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rhizoma dioscoreae
lyophilizing
medicine
application
preparation
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CN103055096B (en
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赵建东
张梅雪
许翠萍
郭美莹
李诗标
许竹梅
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Jinan Sunnypharmacy Co ltd
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Jinan Kangzhong Pharmaceutical Research and Development Co Ltd
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Abstract

The invention relates to an application for freeze-dried Chinese yam in medicine preparation, which is characterized that the freeze-dried Chinese yam is applied to preparation for a medicine for tonifying spleen and nourishing stomach, promoting the secretion of saliva and reinforcing lungs, and tonifying kidney and arresting seminal emission. The freeze-dried Chinese yam represents a better curative effect than the processed products of the traditional Chinese yam in lots of experiments, and especially represents a better curative effect for tonifying spleen and nourishing stomach, promoting the secretion of saliva and reinforcing lungs, and tonifying kidney and arresting seminal emission.

Description

The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine
Technical field
The present invention relates to medicine, the particularly application of a kind of lyophilizing Rhizoma Dioscoreae in the preparation medicine belongs to medical technical field.
Background technology
Rhizoma Dioscoreae original name Rhizoma Dioscoreae is the rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.It is a kind of common vegetable, also is important simply Chinese medicine.Shennong's Herbal put down in writing its be medicine be again the tonic good merchantable brand, in the edible history in existing more than 2000 year of China.Compendium of Material Medica record Rhizoma Dioscoreae " tonify deficiency is thin, except cold and heat pathogen, invigorating middle warmer, and physical strength profiting, longue meat, reinforcing YIN-essence takes normal hearing and eyesight for a long time, makes light of one's life by commiting suicide and prolongs life." the modern study discovery; Rhizoma Dioscoreae is except containing the compositions such as crude fibre, pectin, amylase, phlegmatic temperament, glycoprotein, allantoin, saponin, batatasins, choline, dopamine, fatty acid, polysaccharide; also contain the indispensable trace element of human body such as iodine, calcium, ferrum and phosphorus; its nutritive value, medical value and disease-resistant mechanism just progressively are found and confirm, and more and more are subject to consumers in general's favor.
The processed product of tradition Rhizoma Dioscoreae has parched with bran, parching with earth, fries, Rhizoma Dioscoreae.The report that the freezing processing method of many Rhizoma Dioscoreaes is arranged in recent years, such as patent of invention 02148599.2, with Rhizoma Dioscoreae soaking sterilization in bactericidal liquid, then after peeling, the cutting Rhizoma Dioscoreae piece is soaked color fixative again with Rhizoma Dioscoreae piece soaking sterilization in bactericidal liquid in colour-keeping liquid, then through quick-freezing, plating water glaze freezes again, manufactured goods Rhizoma Dioscoreae piece.Patent of invention 95111876.5, with fresh Rhizoma dioscoreae through cleaning, peeling, sterilization, section, freezing vacuum dehydration, quality examination, pulverize, sieve, again sterilization treatment, metering pack, sampling chemical examination, vacuum seal, packing, finished product vanning warehouse-in.Prior art provides the method for lyophilizing Rhizoma Dioscoreae, the medicinal effects of lyophilizing Rhizoma Dioscoreae is not made targetedly and being summed up.
We find that lyophilizing Rhizoma Dioscoreae processed product than traditional Rhizoma Dioscoreae in many tests shows better curative effect, and the efficacy performance of particularly spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission goes out better curative effect.Estimate the quality index of its spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission effect apparently higher than the Rhizoma Dioscoreae decoction pieces.
Summary of the invention
An object of the present invention is to provide the technique of lyophilizing Rhizoma Dioscoreae.Another object of the present invention provides the application of lyophilizing Rhizoma Dioscoreae in the preparation medicine, and feature is the application in the medicine of preparation spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.
The technique of a kind of lyophilizing Rhizoma Dioscoreae may further comprise the steps:
1) fresh Rhizoma dioscoreae raw material is removed impurity, is cut into the Rhizoma Dioscoreae section of 3-15cm;
2) with the sabot of Rhizoma Dioscoreae section, sabot weight is 5-8 ㎏/㎡, is cooled to gradually 60 ℃ of-20 ℃~– and carries out pre-freeze;
3) to be evacuated to system's absolute pressure be 40~60Pa to sublimation drying, begins to be heated to 30 ℃~60 ℃, sublimation drying 15~24 hours;
4) parsing-desiccation keeps temperature of charge at 35 ℃~65 ℃, makes water content reach 2~3%, gets the lyophilizing Rhizoma Dioscoreae.
The technique of lyophilizing Rhizoma Dioscoreae of the present invention, being evacuated to system's absolute pressure during described sublimation drying is 50Pa, begins to be heated to 45 ℃~55 ℃, sublimation drying 15~20 hours.
The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine, feature are the application in the medicine of preparation spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission, for the preparation of strengthening immunity, defying age, antioxidant activity, antitumor, the medicine for the treatment of diabetes.
The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine that the present invention is above-mentioned is directly to pulverize with the lyophilizing Rhizoma Dioscoreae, is prepared into powder, pill.
The application of the above-mentioned lyophilizing Rhizoma Dioscoreae of the present invention in the preparation medicine is take the lyophilizing Rhizoma Dioscoreae as raw material, through extracting, is prepared into powder, granule, pill, tablet, capsule with extract.
The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine that the present invention is above-mentioned is take the lyophilizing Rhizoma Dioscoreae as raw material, and other prepared slices of Chinese crude drugs of compatibility through extracting, are prepared into powder, granule, pill, tablet, capsule with extract.
The above-mentioned Rhizoma Dioscoreae of the present invention comprises tuber and the Bulbilus dioscoreae of Dioscoreaceae (Dioscoreaceae) plant Rhizoma Dioscoreae (DioscoreaoppositaThunb.).
The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine that the present invention is above-mentioned is to make oral formulations take the lyophilizing Rhizoma Dioscoreae as raw material, takes the preparation that is equivalent to lyophilizing Rhizoma Dioscoreae 3-30g every day, divides and takes for 2-3 time.
Below by test example usefulness of the present invention is described.
Rhizoma Dioscoreae has multiple biological activity, and the polysaccharide in the Rhizoma Dioscoreae is the spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission main composition, and the effect that strengthens immunity, defying age, antioxidant activity, antitumor, treatment diabetes is arranged.Contain water soluble polysaccharide, saponins, oligosaccharide, protein and aminoacid etc. in the water-soluble extractives, often be used as the quality index of estimating its spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission effect.
This test example adopts the phenol sulfuric acid process to measure the content of polysaccharide, adopts that " one one of Chinese pharmacopoeia version in 2010, appendix XA method is carried out the water-soluble extractives assay.The result: two composition content lyophilizing Rhizoma Dioscoreaes are apparently higher than the Rhizoma Dioscoreae decoction pieces.
1, preparation Rhizoma Dioscoreae decoction pieces and lyophilizing Rhizoma Dioscoreae
Get Rhizoma Dioscoreae and wash, with removing yam skin, 1. Rhizoma Dioscoreae is cut into the thin slice about 3mm, put and dry in the constant temperature oven to constant weight, get the Rhizoma Dioscoreae decoction pieces; 2. be cut into the Rhizoma Dioscoreae section of length 15cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is about 5-8Kg/ ㎡; Solidification point is controlled between-28~-32 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃, when temperature of charge and heating-up temperature near the time dry the end, get the lyophilizing Rhizoma Dioscoreae.
2, Rhizoma Dioscoreae decoction pieces and lyophilizing Rhizoma Dioscoreae water-soluble extractives, determination of polysaccharide the results are shown in following table
? Water extraction content (%) Polyoses content (%)
The Rhizoma Dioscoreae decoction pieces 17.26 5.82
The lyophilizing Rhizoma Dioscoreae 36.17 26.36
The specific embodiment
The technique of a kind of lyophilizing Rhizoma Dioscoreae may further comprise the steps:
1) fresh Rhizoma dioscoreae raw material is removed impurity, is cut into the Rhizoma Dioscoreae section of 3-15cm;
2) with the sabot of Rhizoma Dioscoreae section, sabot weight is 5-8 ㎏/㎡, is cooled to gradually 60 ℃ of-20 ℃~– and carries out pre-freeze;
3) to be evacuated to system's absolute pressure be 40~60Pa to sublimation drying, begins to be heated to 30 ℃~60 ℃, sublimation drying 15~24 hours;
4) parsing-desiccation keeps temperature of charge at 35 ℃~65 ℃, makes water content reach 2~3%, gets the lyophilizing Rhizoma Dioscoreae.
The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine, feature are the application in the medicine of preparation spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.
The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine, feature are the application in the medicine of preparation spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission, are used for strengthening immunity, defying age, antioxidant activity, antitumor, treatment diabetes.
The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine is directly to pulverize with the lyophilizing Rhizoma Dioscoreae, is prepared into powder, pill.
The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine is take the lyophilizing Rhizoma Dioscoreae as raw material, through extracting, is prepared into powder, granule, pill, tablet, capsule with extract.
The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine is take the lyophilizing Rhizoma Dioscoreae as raw material, and other prepared slices of Chinese crude drugs of compatibility through extracting, are prepared into powder, granule, pill, tablet, capsule with extract.
The above-mentioned Rhizoma Dioscoreae of the present invention comprises tuber and the Bulbilus dioscoreae of Dioscoreaceae (Dioscoreaceae) plant Rhizoma Dioscoreae (DioscoreaoppositaThunb.).
The application of lyophilizing Rhizoma Dioscoreae in the preparation medicine that the present invention is above-mentioned is to make oral formulations take the lyophilizing Rhizoma Dioscoreae as raw material, takes the preparation that is equivalent to lyophilizing Rhizoma Dioscoreae 3-30g every day, divides and takes for 2-3 time.
Embodiment 1
Get new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 15cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is about 5Kg/ ㎡; Solidification point is controlled at-28 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.Make the lyophilizing Rhizoma Dioscoreae.
Get the lyophilizing Rhizoma Dioscoreae, pulverize, cross 80 mesh sieves, be used for the treatment of trusted subordinate's deficiency-distension, anorexia each serving 3g, took 2 times in 1 day, cured in 2 days.
Embodiment 2
Get new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 3cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is 8Kg/ ㎡; Solidification point is controlled between-32 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.Make the lyophilizing Rhizoma Dioscoreae.
Get the lyophilizing Rhizoma Dioscoreae, pulverize, cross 80 mesh sieves, water is general to be ball, and it is many to be used for the treatment of frequent micturition, every 10g that takes, and water send down, every day 3 times, cures in 7 days.
Embodiment 3
Adopt ZG-100 ㎡ type vacuum freeze drier.Choose new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 3cm, sabot, sabot weight is about 7kg/ ㎡, carries out pre-freeze to-28 ℃ after lowering the temperature gradually 2 hours; Then be evacuated to the absolute pressure 40Pa of system, begin to be heated to 35 ℃, sublimation drying 15 hours; Keep again 35 ℃ of temperature of charge, when temperature of charge and heating-up temperature near the time dry the end, get the lyophilizing Rhizoma Dioscoreae.
Get the lyophilizing Rhizoma Dioscoreae powder and be broken to coarse powder, add 4 times of water gagings, stir to extract 4 hours at 20 ℃, totally 2 times, merge extractive liquid, filters, and is centrifugal, the centrifugal liquid freeze drying box of packing into, lyophilizing.Get the lyophilizing Rhizoma Dioscoreae extract.
Get Rhizoma Atractylodis Macrocephalae 1kg, Radix Ginseng 0.5 kg uses water extraction 2 times, adds 8 times of water gagings for the first time, extracted 1.5 hours, and added 6 times of water gagings for the second time and extracted 1 hour, merge extractive liquid, filters, concentrated, drying gets the Rhizoma Atractylodis Macrocephalae, Radix Ginseng extract, adds lyophilizing Rhizoma Dioscoreae extract 300g, mixing, starch slurry is granulated, drying, granulate, it is an amount of to add Pulvis Talci, and tabletting is used for the treatment of weakness of the spleen and stomach, anorexia, 12 of every days, minute 3 clothes.
Embodiment 4
Get the lyophilizing Rhizoma Dioscoreae extract that embodiment 3 makes, add an amount of dextrin, granulate, reduced vacuum is dry, and granulate is packed as the 10g/ bag, gets lyophilizing Rhizoma Dioscoreae granule, and patients with lung cancer is oral, 2 bags of every days (being equivalent to lyophilizing Rhizoma Dioscoreae 50g), minute 2 clothes.
Embodiment 5
Get the lyophilizing Rhizoma Dioscoreae extract that embodiment 3 makes, add an amount of methylcellulose, granulate, reduced vacuum is dry, and granulate incapsulates, and gets lyophilizing Rhizoma Dioscoreae capsule, and colorectal cancer patients is oral, 15 of every days (being equivalent to lyophilizing Rhizoma Dioscoreae 15g), minute 3 clothes.
Embodiment 6
Get the lyophilizing Rhizoma Dioscoreae that embodiment 1 makes and divide, add an amount of differential silica gel, pill, reduced vacuum is dry, is packed as the 10g/ bag, and the glycosuria patient is oral, 2 bags of every days, minute 2 clothes.
Embodiment 7
Adopt ZG-100 ㎡ type vacuum freeze drier, choose new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 10cm, sabot was carried out pre-freeze to-30 ℃ after lowering the temperature gradually 2 hours; Then be evacuated to the absolute pressure 50Pa of system and begin to be heated to 40 ℃, sublimation drying 18 hours; Keep again temperature of charge at 45 ℃, make water content reach rear discharging below 2%.Get the lyophilizing Rhizoma Dioscoreae.
Get Radix Codonopsis 600g, Rhizoma Atractylodis Macrocephalae 600g, Poria 600g, lyophilizing Rhizoma Dioscoreae 1000g, use water extraction 2 times, add 10 times of water gagings for the first time, extracted 1 hour, add 6 times of water gagings for the second time and extracted 1 hour, merge extractive liquid, filters, and is concentrated, drying is pulverized, and adds dextrin, granulate drying, granulate, get granule, be used for the treatment of weakness of the spleen and stomach, the lack of appetite body is tired, women leucorrhea disease, every day, 30g divided clothes 2 times.
Embodiment 8
Adopt ZG-100 ㎡ type vacuum freeze drier.Choose new fresh Rhizoma dioscoreae Bulbilus dioscoreae, clean roguing, sabot, sabot weight is 7kg/ ㎡, carries out pre-freeze to-28 ℃ after lowering the temperature gradually 2 hours; Then be evacuated to the absolute pressure 40Pa of system, begin to be heated to 35 ℃, sublimation drying 15 hours; Keep again 35 ℃ of temperature of charge, when temperature of charge and heating-up temperature near the time dry the end, get the lyophilizing Rhizoma Dioscoreae.

Claims (7)

1. the technique of a lyophilizing Rhizoma Dioscoreae may further comprise the steps:
1) fresh Rhizoma dioscoreae raw material is removed impurity, is cut into the Rhizoma Dioscoreae section of 3-15cm;
2) with the sabot of Rhizoma Dioscoreae section, sabot weight is 5-8 ㎏/㎡, is cooled to gradually 60 ℃ of-20 ℃~– and carries out pre-freeze;
3) to be evacuated to system's absolute pressure be 40~60Pa to sublimation drying, begins to be heated to 30 ℃~60 ℃, sublimation drying 15~24 hours;
4) parsing-desiccation keeps temperature of charge at 35 ℃~65 ℃, makes water content reach 2~3%, gets the lyophilizing Rhizoma Dioscoreae.
2. the lyophilizing Rhizoma Dioscoreae is in the application of preparation in the medicine, it is characterized in that preparing the spleen reinforcing nourishing the stomach, the application in the medicine of the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.
3. according to claim 2 lyophilizing Rhizoma Dioscoreae is in the application of preparation in the medicine, it is characterized in that preparing the spleen reinforcing nourishing the stomach, the application in the medicine of the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission, for the preparation of strengthening immunity, defying age, antioxidant activity, antitumor, the medicine for the treatment of diabetes.
According to claim 2 or the lyophilizing Rhizoma Dioscoreae of claim 3 in the application of preparation in the medicine, it is characterized in that directly pulverizing with the lyophilizing Rhizoma Dioscoreae, be prepared into powder, pill.
According to claim 2 or the lyophilizing Rhizoma Dioscoreae of claim 3 in the application of preparation in the medicine, it is characterized in that take the lyophilizing Rhizoma Dioscoreae as raw material, through extracting, be prepared into powder, granule, pill, tablet, capsule with extract.
According to claim 2 or the lyophilizing Rhizoma Dioscoreae of claim 3 in the application of preparation in the medicine, it is characterized in that take the lyophilizing Rhizoma Dioscoreae as raw material other prepared slices of Chinese crude drugs of compatibility through extracting, are prepared into powder, granule, pill, tablet, capsule with extract.
According to claim 1 or the lyophilizing Rhizoma Dioscoreae of claim 2 or claim 3 or claim 4 or claim 5 or claim 6 in the application of preparation in the medicine, it is characterized in that Rhizoma Dioscoreae is tuber and the Bulbilus dioscoreae of Dioscoreaceae plant Rhizoma Dioscoreae.
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CN103478637A (en) * 2013-08-23 2014-01-01 广西大学 Method for preparing dried Chinese yam through vacuum freeze drying
CN103599322A (en) * 2013-11-07 2014-02-26 培力(南宁)药业有限公司 Preparation method of Chinese yam formula granules
CN103652929A (en) * 2013-12-31 2014-03-26 陈慧婷 Sorghum and semen coicis dispersible tablet and preparation method thereof
CN104154713A (en) * 2014-08-25 2014-11-19 济南康众医药科技开发有限公司 Lamiophlomis freeze-drying method
CN104165498A (en) * 2014-08-25 2014-11-26 济南康众医药科技开发有限公司 Scutellaria baicalensis freeze-drying method
CN107439869A (en) * 2017-08-02 2017-12-08 广西壮族自治区药用植物园 The preparation method of liquid fresh yam drink
CN108782909A (en) * 2018-09-14 2018-11-13 铜川药王医都科技有限公司 A kind of summer health care tea

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103478637A (en) * 2013-08-23 2014-01-01 广西大学 Method for preparing dried Chinese yam through vacuum freeze drying
CN103599322A (en) * 2013-11-07 2014-02-26 培力(南宁)药业有限公司 Preparation method of Chinese yam formula granules
CN103599322B (en) * 2013-11-07 2016-08-17 培力(南宁)药业有限公司 A kind of Yam dispensing granule preparation method
CN103652929A (en) * 2013-12-31 2014-03-26 陈慧婷 Sorghum and semen coicis dispersible tablet and preparation method thereof
CN103652929B (en) * 2013-12-31 2015-06-17 陈慧婷 Sorghum and semen coicis dispersible tablet and preparation method thereof
CN104154713A (en) * 2014-08-25 2014-11-19 济南康众医药科技开发有限公司 Lamiophlomis freeze-drying method
CN104165498A (en) * 2014-08-25 2014-11-26 济南康众医药科技开发有限公司 Scutellaria baicalensis freeze-drying method
CN107439869A (en) * 2017-08-02 2017-12-08 广西壮族自治区药用植物园 The preparation method of liquid fresh yam drink
CN108782909A (en) * 2018-09-14 2018-11-13 铜川药王医都科技有限公司 A kind of summer health care tea

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