CN108671008A - Radix pseudostellariae is fresh to carry freeze-dried powder medicine materical crude slice - Google Patents
Radix pseudostellariae is fresh to carry freeze-dried powder medicine materical crude slice Download PDFInfo
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- CN108671008A CN108671008A CN201810733215.2A CN201810733215A CN108671008A CN 108671008 A CN108671008 A CN 108671008A CN 201810733215 A CN201810733215 A CN 201810733215A CN 108671008 A CN108671008 A CN 108671008A
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- Prior art keywords
- radix pseudostellariae
- fresh
- freeze
- decoction
- materical crude
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Alternative & Traditional Medicine (AREA)
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Abstract
The invention discloses a kind of " radix pseudostellariae is fresh to carry freeze-dried powder medicine materical crude slice ", are primarily characterized in that：Radix pseudostellariae harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution is freeze-dried after being condensed into clear cream, then is vacuum-packed after crushing, being sieved.The water content of powder decoction pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of radix pseudostellariae medicine materical crude slice.
Background technology
Chinese medicine radix pseudostellariae is pinkwort caryophyllaceous ginsengPseudostellaria heterophylla （Miq.）Pax
The dried root of ex Pax et Hoffm. has and replenishes qi to invigorate the spleen, promoting production of body fluid and nourishing the lung effect.It is tired that this product is mainly used for spleen deficiency body,
Loss of appetite, eak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, the treatment of the diseases such as dryness of the lung dry cough, is most common one on tcm clinical practice
Taste Chinese medicine.The processing method of traditional radix pseudostellariae is：Summer cauline leaf is excavated when largely withered, is cleaned, and is removed fibrous root, is set in boiling water
It dries after slightly scalding or directly dries, pack, storage and transportation.Thus obtained medicine materical crude slice volume is big, and Hygienic Standard is poor, is easy to make moist, grow
It is mould, infested, it is unfavorable for taking care of, storage and transportation cost are high.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to
It ensures, patient takes inconvenience, works slow.Therefore, develop a kind of stable quality is reliable, storage/transportation is at low cost, be conducive to protect
Pipe, carrying and easy to use, rapid-action novel radix pseudostellariae medicine materical crude slice, it is imperative.Existing market radix pseudostellariae medicine materical crude slice, in addition to tradition
Except medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both using traditional medicine materical crude slice as raw material, matter
Amount is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes；Concentrated granular can only extract water outlet
Soluble components.
Invention content
The invention discloses a kind of " radix pseudostellariae is fresh to carry freeze-dried powder medicine materical crude slice ", are primarily characterized in that：In radix pseudostellariae
After harvesting, clean in time, removal impurity and the dis-medicinal part such as silt, in taken advantage of in 24 hours using fresh herb tap water clean and be cut into 2 ~
The piece of 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering,
Dregs pressing takes juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.15 ~ 1.25 clear cream.It is cold in -20 ~ -40 DEG C of vacuum after gained clear cream is freezed 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators
It is lyophilized dry.Lyophilized products be dried under vacuum to again at 60 ~ 80 DEG C water content be less than 10%, crush, cross 60 mesh sieve, vacuum packaging to get at
Product.The clinical general usage amount of this medicine materical crude slice is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter pill, powder, capsule
And in tablet, to substantially increase the convenience and compliance of Clinical practice, be conducive to the treatment of clinical acute disease.
The present invention solve traditional radix pseudostellariae medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested,
The shortcomings such as the poor, unstable quality of hygiene condition, due to being to take advantage of fresh extraction, quality is than ultramicro grinding medicine materical crude slice and concentrated granular
Medicine materical crude slice is more preferable.
Specific embodiment
It after radix pseudostellariae medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours certainly
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, the dregs of a decoction
Press extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It is secondary to squeeze the juice, collect concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.20 to be concentrated into relative density
Clear cream.By the clear cream of gained after -80 DEG C are freezed 12 hours, in -40 DEG C of vacuum freeze dryings.Dried object is dry with 60 DEG C of vacuum again
It is dry to water content be 8%, crush, cross 60 mesh sieve, be vacuum-packed to get finished product.
Claims (2)
1. a kind of radix pseudostellariae is fresh to carry freeze-dried powder medicine materical crude slice, it is primarily characterized in that：It is net in time after the harvesting of radix pseudostellariae medicinal material
Choosing, removal impurity and the dis-medicinal part such as silt, keeps medicinal material surface wettability, cleans and cuts in taking advantage of using fresh herb tap water in 24 hours
At the piece of 2 ~ 5mm thickness, the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight is added, impregnate and constantly stirs 5 ~ 30 minutes, filtering, dregs pressing takes
Juice；The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects medicine
Juice；Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and it is 1.15 ~ 1.25 to be concentrated into relative density
Clear cream；After gained clear cream freezes 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, in -20 ~ -40 DEG C of vacuum freeze dryings；Freeze-drying
Object is dried under vacuum to water content at 60 ~ 80 DEG C and is less than 12% again, crushes, and crosses 60 mesh sieve, is vacuum-packed to get finished product.
2. radix pseudostellariae according to claim 1 is fresh to carry freeze-dried powder medicine materical crude slice, it is primarily characterized in that：Clinic generally makes
Dosage is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733215.2A CN108671008A (en) | 2018-07-06 | 2018-07-06 | Radix pseudostellariae is fresh to carry freeze-dried powder medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733215.2A CN108671008A (en) | 2018-07-06 | 2018-07-06 | Radix pseudostellariae is fresh to carry freeze-dried powder medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108671008A true CN108671008A (en) | 2018-10-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733215.2A Withdrawn CN108671008A (en) | 2018-07-06 | 2018-07-06 | Radix pseudostellariae is fresh to carry freeze-dried powder medicine materical crude slice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108671008A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528803A (en) * | 2018-11-20 | 2019-03-29 | 福建省闽东力捷迅药业有限公司 | A kind of preparation method of Radix Pseudostellariae extract and its Radix Pseudostellariae extract and detection method of preparation |
-
2018
- 2018-07-06 CN CN201810733215.2A patent/CN108671008A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528803A (en) * | 2018-11-20 | 2019-03-29 | 福建省闽东力捷迅药业有限公司 | A kind of preparation method of Radix Pseudostellariae extract and its Radix Pseudostellariae extract and detection method of preparation |
| CN109528803B (en) * | 2018-11-20 | 2021-11-23 | 福建省闽东力捷迅药业股份有限公司 | Preparation method of radix pseudostellariae extract, radix pseudostellariae extract prepared by preparation method and detection method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181019 |
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| WW01 | Invention patent application withdrawn after publication |