CN108671003A - Root of Aucklandia lappa Decne is fresh to carry freeze-dried powder medicine materical crude slice - Google Patents
Root of Aucklandia lappa Decne is fresh to carry freeze-dried powder medicine materical crude slice Download PDFInfo
- Publication number
- CN108671003A CN108671003A CN201810733233.0A CN201810733233A CN108671003A CN 108671003 A CN108671003 A CN 108671003A CN 201810733233 A CN201810733233 A CN 201810733233A CN 108671003 A CN108671003 A CN 108671003A
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- CN
- China
- Prior art keywords
- root
- aucklandia lappa
- lappa decne
- fresh
- materical crude
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 title claims abstract description 24
- 244000272264 Saussurea lappa Species 0.000 title claims abstract description 20
- 235000006784 Saussurea lappa Nutrition 0.000 title claims abstract description 20
- 239000000843 powder Substances 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000006071 cream Substances 0.000 claims abstract description 7
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000006187 pill Substances 0.000 claims abstract description 3
- 239000002775 capsule Substances 0.000 claims abstract 2
- 238000003306 harvesting Methods 0.000 claims abstract 2
- 239000003826 tablet Substances 0.000 claims abstract 2
- 239000000463 material Substances 0.000 claims description 5
- HRYLQFBHBWLLLL-UHFFFAOYSA-N (+)-costunolide Natural products C1CC(C)=CCCC(C)=CC2OC(=O)C(=C)C21 HRYLQFBHBWLLLL-UHFFFAOYSA-N 0.000 claims description 3
- CUGKULNFZMNVQI-UHFFFAOYSA-N Costunolid I Natural products CC1=CCC=C(/C)CCC2C(C1)OC(=O)C2=C CUGKULNFZMNVQI-UHFFFAOYSA-N 0.000 claims description 3
- HRYLQFBHBWLLLL-AHNJNIBGSA-N costunolide Chemical compound C1CC(/C)=C/CC\C(C)=C\[C@H]2OC(=O)C(=C)[C@@H]21 HRYLQFBHBWLLLL-AHNJNIBGSA-N 0.000 claims description 3
- MMTZAJNKISZWFG-UHFFFAOYSA-N costunolide Natural products CC1CCC2C(CC(=C/C=C1)C)OC(=O)C2=C MMTZAJNKISZWFG-UHFFFAOYSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 235000021419 vinegar Nutrition 0.000 claims description 3
- 239000000052 vinegar Substances 0.000 claims description 3
- 238000006356 dehydrogenation reaction Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 2
- -1 clean in time Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " root of Aucklandia lappa Decne is fresh to carry freeze-dried powder medicine materical crude slice ", are primarily characterized in that：Root of Aucklandia lappa Decne harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution is freeze-dried after being condensed into clear cream, then is vacuum-packed after crushing, being sieved.The water content of powder decoction pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of root of Aucklandia lappa Decne medicine materical crude slice.
Background technology
Chinese medicine root of Aucklandia lappa Decne is feverfew root of Aucklandia lappa DecneAucklandia lappaDecne. dry root has promoting qi circulation and relieving pain, is good for
The effect of spleen helps digestion.This product can be used for chest side of body, abdominal distention, weight after rush down dysentery, dyspepsia, the treatment of do not feel like eating etc., in being
Cure clinically common a herb.The processing method of traditional root of Aucklandia lappa Decne is：After medicinal material is excavated, removing silt and fibrous root, segment,
Big vertical profile again hits tertia at valve after dry, is packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, wraps
Dress.Such medicine materical crude slice volume is big, and Hygienic Standard is poor, is easy to make moist, is mildew, infested, being unfavorable for taking care of, storage and transportation cost
It is high.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, it opens
Sending out a kind of, stable quality is reliable, storage/transportation is at low cost, conducive to keeping, carrying and easy to use, rapid-action novel root of Aucklandia lappa Decne drink
Piece, it is imperative.Existing market root of Aucklandia lappa Decne medicine materical crude slice, other than traditional medicine materical crude slice, also Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice two
Kind form, but both using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve
The problem of certainly medicinal material pollutes；Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " root of Aucklandia lappa Decne is fresh to carry freeze-dried powder medicine materical crude slice ", are primarily characterized in that：It is harvested in root of Aucklandia lappa Decne
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.15 ~ 1.25 clear cream.It is cold in -20 ~ -40 DEG C of vacuum after gained clear cream is freezed 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators
It is lyophilized dry.Lyophilized products be dried under vacuum to again at 60 ~ 80 DEG C water content be less than 10%, crush, cross 60 mesh sieve, vacuum packaging to get at
Product.Finished product medicine materical crude slice contains costunolide（C15H20O2）With vinegar in dehydrogenation root of Aucklandia lappa Decne（C15H18O2）Total amount be no less than 2.0%.
The clinical general usage amount of this medicine materical crude slice is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter pill, powder, glue
In wafer and tablet, to substantially increase the convenience and compliance of Clinical practice, be conducive to the treatment of clinical acute disease.
The present invention solve traditional root of Aucklandia lappa Decne medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after root of Aucklandia lappa Decne medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature be set as 70 DEG C, be concentrated into relative density be 1.20 it is clear
Cream.By the clear cream of gained after -80 DEG C are freezed 12 hours, in -40 DEG C of vacuum freeze dryings.Dried object is dried in vacuo with 60 DEG C again
It is 8% to water content, crushes, crosses 60 mesh sieve, be vacuum-packed to get finished product.Finished product medicine materical crude slice contains costunolide（C15H20O2）With go
Vinegar in hydrogen root of Aucklandia lappa Decne（C15H18O2）Total amount be 2.5%.
Claims (2)
1. a kind of root of Aucklandia lappa Decne is fresh to carry freeze-dried powder medicine materical crude slice, it is primarily characterized in that：After the harvesting of root of Aucklandia lappa Decne medicinal material, clean in time,
Impurity and the dis-medicinal part such as silt are removed, medicinal material surface wettability is kept, cleans in taking advantage of using fresh herb tap water in 24 hours and is cut into 2
The water of 1 ~ 5 times of 50 ~ 70 DEG C of weight is added in the piece of ~ 5mm thickness, impregnates and constantly stirs 5 ~ 30 minutes, filtering, dregs pressing takes juice；
The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；
Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and it is 1.15 ~ 1.25 to be concentrated into relative density
Clear cream；After gained clear cream freezes 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, in -20 ~ -40 DEG C of vacuum freeze dryings；Lyophilized products
Water content is dried under vacuum at 60 ~ 80 DEG C again and is less than 12%, is crushed, 60 mesh sieve is crossed, is vacuum-packed to get finished product；Finished product medicine materical crude slice contains
Costunolide（C15H20O2）With vinegar in dehydrogenation root of Aucklandia lappa Decne（C15H18O2）Total amount be no less than 2.0%.
2. root of Aucklandia lappa Decne according to claim 1 is fresh to carry freeze-dried powder medicine materical crude slice, it is primarily characterized in that：Clinic generally uses
Amount is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733233.0A CN108671003A (en) | 2018-07-06 | 2018-07-06 | Root of Aucklandia lappa Decne is fresh to carry freeze-dried powder medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733233.0A CN108671003A (en) | 2018-07-06 | 2018-07-06 | Root of Aucklandia lappa Decne is fresh to carry freeze-dried powder medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108671003A true CN108671003A (en) | 2018-10-19 |
Family
ID=63813482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733233.0A Withdrawn CN108671003A (en) | 2018-07-06 | 2018-07-06 | Root of Aucklandia lappa Decne is fresh to carry freeze-dried powder medicine materical crude slice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108671003A (en) |
-
2018
- 2018-07-06 CN CN201810733233.0A patent/CN108671003A/en not_active Withdrawn
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181019 |