CN108498567A - Radix Astragali is fresh to carry freeze-drying granule pieces - Google Patents
Radix Astragali is fresh to carry freeze-drying granule pieces Download PDFInfo
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- CN108498567A CN108498567A CN201810733200.6A CN201810733200A CN108498567A CN 108498567 A CN108498567 A CN 108498567A CN 201810733200 A CN201810733200 A CN 201810733200A CN 108498567 A CN108498567 A CN 108498567A
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- China
- Prior art keywords
- fresh
- radix astragali
- drying
- decoction
- clear cream
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- 239000009636 Huang Qi Substances 0.000 title claims abstract description 15
- 238000004108 freeze drying Methods 0.000 title claims abstract description 6
- 239000008187 granular material Substances 0.000 title claims abstract description 6
- 239000006071 cream Substances 0.000 claims abstract description 13
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 4
- 239000003826 tablet Substances 0.000 claims abstract description 4
- 235000020985 whole grains Nutrition 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 239000006187 pill Substances 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 241001061264 Astragalus Species 0.000 claims description 5
- 235000006533 astragalus Nutrition 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 3
- SMDOOINVMJSDPS-UHFFFAOYSA-N Astragaloside Natural products C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)OC2C(C(OC3C(C(O)C(O)C(CO)O3)O)C(O)C(CO)O2)O)=C1 SMDOOINVMJSDPS-UHFFFAOYSA-N 0.000 claims description 2
- 235000010110 Astragalus glycyphyllos Nutrition 0.000 claims description 2
- QMNWISYXSJWHRY-XWJCTJPOSA-N astragaloside Chemical compound O1[C@H](C(C)(O)C)CC[C@]1(C)[C@@H]1[C@@]2(C)CC[C@]34C[C@]4(CC[C@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)CO4)O)C4(C)C)C4[C@@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)CC3[C@]2(C)C[C@@H]1O QMNWISYXSJWHRY-XWJCTJPOSA-N 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 238000003860 storage Methods 0.000 description 3
- 210000004233 talus Anatomy 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 238000009412 basement excavation Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 208000021090 palsy Diseases 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " Radix Astragali is fresh to carry freeze-drying granule pieces ", are primarily characterized in that：Radix Astragali harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution is freeze-dried after being condensed into clear cream, then is vacuum-packed after crushing, granulation, drying, whole grain.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of Radix Astragali medicine materical crude slice.
Background technology
Chinese herbal medicine astragalus is the dry root of legume astragalus mongolicus or Astragalus membranacus.Spring, two season of autumn excavation, remove fibrous root and
Root head, is dried.Radix Astragali has tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, shengjin nourishing, move stagnation and palsy, pus draining and toxin expelling, sore
Myogenic and other effects is most common a herb on tcm clinical practice.The processing method of traditional Radix Astragali is：After medicinal material is excavated, directly
It connects and dries/dry, bundle and package, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Such medicine materical crude slice volume
Greatly, Hygienic Standard is poor, is easy to make moist, is mildew, infested, being unfavorable for taking care of, storage and transportation cost are high.In addition, such drink
Tablet quality stability is poor, and clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, developing a kind of stable quality can
Lean on, storage/transportation is at low cost, conducive to keeping, carry and easy to use, rapid-action novel Radix Astragali medicine materical crude slice, it is imperative.At present
Market Radix Astragali medicine materical crude slice, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both
Using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes；
Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " Radix Astragali is fresh to carry freeze-drying granule pieces ", are primarily characterized in that：It is harvested in Radix Astragali
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.15 ~ 1.25 clear cream.This clear cream is left and taken to 0.5% ~ 3% spare, vacuum freeze drying again after -80 DEG C of remaining clear cream is freezed.It receives
Collect lyophilized products, be mixed with particle with above-mentioned spare clear cream after crushed, then after drying, whole grain, be vacuum-packed up at
Product.Finished product medicine materical crude slice Astragaloside content must not be less than 0.060%.The clinical general usage amount of this medicine materical crude slice is 1 ~ 5g, can both enter decoction and decoct
It takes, take after mixing it with water, also can directly enter in pill, powder, capsule and tablet, to substantially increase the convenience of Clinical practice and suitable
Ying Xing is conducive to the treatment of clinical acute disease.
The present invention solve traditional Radix Astragali medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after Milkvetch Root is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature be set as 70 DEG C, be concentrated into relative density be 1.20 it is clear
Cream.This clear cream is left and taken to 1% spare, vacuum freeze drying again after -80 DEG C of remaining clear cream is freezed.Collect lyophilized products, after crushed with
Above-mentioned spare clear cream is mixed with particle, then after drying, whole grain, vacuum packaging is got product.Finished product medicine materical crude slice first containing Radix Astragali
Glycosides 0.065%.
Claims (3)
1. a kind of Radix Astragali is fresh to carry freeze-drying granule pieces, it is primarily characterized in that：After Milkvetch Root harvesting, clean in time,
Impurity and the dis-medicinal part such as silt are removed, medicinal material surface wettability is kept, cleans in taking advantage of using fresh herb tap water in 24 hours and is cut into 2
The water of 1 ~ 5 times of 50 ~ 70 DEG C of weight is added in the piece of ~ 5mm thickness, impregnates and constantly stirs 5 ~ 30 minutes, filtering, dregs pressing takes juice；
The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；
Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and it is 1.15 ~ 1.25 to be concentrated into relative density
Clear cream；This clear cream is left and taken to 0.5% ~ 3% spare, vacuum freeze drying again after -80 DEG C of remaining clear cream is freezed.
2. collecting lyophilized products, it is mixed with particle with above-mentioned spare clear cream after crushed, then after drying, whole grain, vacuum packet
Dress is got product；Finished product medicine materical crude slice Astragaloside content is not less than 0.060%.
3. Radix Astragali according to claim 1 is fresh to carry freeze-drying granule pieces, it is primarily characterized in that：Clinic generally uses
Amount is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733200.6A CN108498567A (en) | 2018-07-06 | 2018-07-06 | Radix Astragali is fresh to carry freeze-drying granule pieces |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733200.6A CN108498567A (en) | 2018-07-06 | 2018-07-06 | Radix Astragali is fresh to carry freeze-drying granule pieces |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108498567A true CN108498567A (en) | 2018-09-07 |
Family
ID=63404187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733200.6A Withdrawn CN108498567A (en) | 2018-07-06 | 2018-07-06 | Radix Astragali is fresh to carry freeze-drying granule pieces |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108498567A (en) |
-
2018
- 2018-07-06 CN CN201810733200.6A patent/CN108498567A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180907 |