CN108619223A - Radix Astragali is fresh to carry vacuum drying powder decoction pieces - Google Patents

Radix Astragali is fresh to carry vacuum drying powder decoction pieces Download PDF

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Publication number
CN108619223A
CN108619223A CN201810733392.0A CN201810733392A CN108619223A CN 108619223 A CN108619223 A CN 108619223A CN 201810733392 A CN201810733392 A CN 201810733392A CN 108619223 A CN108619223 A CN 108619223A
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CN
China
Prior art keywords
radix astragali
decoction
fresh
water
vacuum drying
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Withdrawn
Application number
CN201810733392.0A
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Chinese (zh)
Inventor
徐璐
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Individual
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Individual
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Priority to CN201810733392.0A priority Critical patent/CN108619223A/en
Publication of CN108619223A publication Critical patent/CN108619223A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of " Radix Astragali is fresh to carry vacuum drying powder decoction pieces ", are primarily characterized in that:Radix Astragali harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, after extracting solution is condensed into clear cream, then be dried under vacuum to water content be less than 10%, crush, be sieved after be vacuum-packed.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule, is conducive to carry, Clinical practice is convenient.

Description

Radix Astragali is fresh to carry vacuum drying powder decoction pieces
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of Radix Astragali medicine materical crude slice.
Background technology
Chinese herbal medicine astragalus is the dry root of legume astragalus mongolicus or Astragalus membranacus.Spring, two season of autumn excavation, remove fibrous root and Root head, is dried.Radix Astragali has tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, shengjin nourishing, move stagnation and palsy, pus draining and toxin expelling, sore Myogenic and other effects is most common a herb on tcm clinical practice.The processing method of traditional Radix Astragali is:After medicinal material is excavated, directly It connects and dries/dry, bundle and package, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Such medicine materical crude slice volume Greatly, Hygienic Standard is poor, is easy to make moist, is mildew, infested, being unfavorable for taking care of, storage and transportation cost are high.In addition, such Huang Stilbene prepared slice quality stability is poor, and clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, it is steady to develop a kind of quality It is fixed reliable, storage/transportation is at low cost, conducive to keeping, carry and easy to use, rapid-action novel Radix Astragali medicine materical crude slice, it is imperative. Radix Astragali medicine materical crude slice currently on the market, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but Both using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve medicinal material dirt The problem of dye;Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " Radix Astragali is fresh to carry vacuum drying powder decoction pieces ", are primarily characterized in that:It is harvested in Radix Astragali Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is 1.15 ~ 1.25 clear cream.The clear cream of gained is dried under vacuum to water content at 60 ~ 80 DEG C and is less than 10%, is crushed, 60 mesh sieve is crossed, Vacuum packaging is to get finished product.Finished product medicine materical crude slice Astragaloside content must not be less than 0.060%.The clinical general usage amount of this Radix Astragali medicine materical crude slice For 1 ~ 5g, it can both enter decoction decoction, take after mixing it with water, also can directly enter in pill, powder, capsule and tablet, to substantially increase The convenience and compliance of Clinical practice, are conducive to the treatment of clinical acute disease.
The present invention solve traditional Radix Astragali medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular Piece is more preferable.
Specific embodiment
It after Milkvetch Root is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature be set as 70 DEG C, be concentrated into relative density be 1.20 it is clear Cream.It is 8% that the clear cream of gained is dried under vacuum to water content at 80 DEG C, is crushed, and crosses 60 mesh sieve, is vacuum-packed to get finished product. Finished product medicine materical crude slice Astragaloside content is 0.080%.

Claims (2)

1. a kind of Radix Astragali is fresh to carry vacuum drying powder decoction pieces, it is primarily characterized in that:It after Radix Astragali harvesting, cleans, removes in time The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice;5 ~ 10 are added in the gained dregs of a decoction The water of times weight, boils 10 ~ 30 minutes, filters while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;Merge above-mentioned concoction, crosses 60 ~ 100 Mesh sieves, and is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, is concentrated into the clear cream that relative density is 1.15 ~ 1.25;By the clear cream of gained 60 ~ It is dried under vacuum to water content at 80 DEG C and is less than 10%, crushes, crosses 60 mesh sieve, is vacuum-packed to get finished product;Finished product medicine materical crude slice Radix Astragali first Glycosides content must not be less than 0.060%.
2. Radix Astragali according to claim 1 is fresh to carry vacuum drying powder decoction pieces, it is primarily characterized in that:Clinic generally uses Amount is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
CN201810733392.0A 2018-07-06 2018-07-06 Radix Astragali is fresh to carry vacuum drying powder decoction pieces Withdrawn CN108619223A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810733392.0A CN108619223A (en) 2018-07-06 2018-07-06 Radix Astragali is fresh to carry vacuum drying powder decoction pieces

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810733392.0A CN108619223A (en) 2018-07-06 2018-07-06 Radix Astragali is fresh to carry vacuum drying powder decoction pieces

Publications (1)

Publication Number Publication Date
CN108619223A true CN108619223A (en) 2018-10-09

Family

ID=63689716

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810733392.0A Withdrawn CN108619223A (en) 2018-07-06 2018-07-06 Radix Astragali is fresh to carry vacuum drying powder decoction pieces

Country Status (1)

Country Link
CN (1) CN108619223A (en)

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Application publication date: 20181009

WW01 Invention patent application withdrawn after publication