CN108888642A - Radix saposhnikoviae is fresh to mention freeze-dried powder medicine materical crude slice - Google Patents

Abstract

The invention discloses a kind of " radix saposhnikoviae is fresh to mention freeze-dried powder medicine materical crude slice ", are primarily characterized in that：After radix saposhnikoviae harvesting, take advantage of fresh washing, slice, juicing, extract, extracting solution is freeze-dried after being condensed into clear cream, then crushed, be sieved after be vacuum-packed.The water content of powder decoction pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule, is conducive to carry, clinical use is convenient.

Description

Radix saposhnikoviae is fresh to mention freeze-dried powder medicine materical crude slice

Technical field

The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of windproof medicine materical crude slice.

Background technique

The effect of Chinese Drug Fangfeng is the dry root of umbelliferae Saposhnikovia divaricata, has and expels pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, relieving convulsion.Face Bed is used for cold headache, rheumatic arthralgia, rubella itch, the treatment of tetanus etc..The processing method of traditional radix saposhnikoviae is：Medicinal material is adopted After digging, silt is removed, directly dries/dries, bundle and package, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, wraps Dress.Such medicine materical crude slice volume is big, and Hygienic Standard is poor, is easy to dampness, mildew, infested, is unfavorable for taking care of, storage and transportation cost It is high.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, it opens Send out that quality is reliable and stable, storage/transportation is at low cost a kind of, conducive to keeping, carry and use Novel wind-proof drink conveniently, rapid-action Piece, it is imperative.Existing market radix saposhnikoviae medicine materical crude slice, other than traditional medicine materical crude slice, there are also Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice two Kind form, but both using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve The problem of certainly medicinal material pollutes；Concentrated granular can only extract water soluble ingredient.

Summary of the invention

The invention discloses a kind of " radix saposhnikoviae is fresh to mention freeze-dried powder medicine materical crude slice ", are primarily characterized in that：It is harvested in radix saposhnikoviae Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm Thick piece.The piece that this is cut is added in 1 ~ 5 times 50 ~ 70 DEG C of weight of water, impregnates and constantly stirs 5 ~ 30 minutes, filtering, medicine Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again Juice collects decoction.Merge above-mentioned decoction, cross 60 ~ 100 meshes, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is 1.15 ~ 1.25 clear cream.It is cold in -20 ~ -40 DEG C of vacuum after gained clear cream is freezed 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators It is lyophilized dry.Lyophilized products are dried under vacuum to water content lower than 10% at 60 ~ 80 DEG C again, crush, and cross 60 meshes, vacuum packaging to get at Product.Finished product glycosides containing macrotin (C₂₂H₂₈O₁₁) and 5-O- methyl visamminol glycosides (C₂₂H₂₈O₁₀) total amount must not be less than 0.40%.The clinical general usage amount of this medicine materical crude slice is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and can also directly enter pill, powder, glue In wafer and tablet, to substantially increase the convenience and compliance of clinical use, be conducive to the treatment of clinical acute disease.

The present invention solve traditional windproof medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend The shortcomings such as the raw poor, unstable quality of condition, due to being to take advantage of fresh extraction, mass ratio pulverizes medicine materical crude slice and concentrated granular drink Piece is more preferable.

Specific embodiment

It after the harvesting of windproof medicinal material, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again Decoction is collected in juicing.Merge above-mentioned decoction, be concentrated under reduced pressure, temperature be set as 70 DEG C, be concentrated into relative density be 1.20 it is clear Cream.By resulting clear cream after -80 DEG C are freezed 12 hours, in -40 DEG C of vacuum freeze dryings.Dried object uses 60 DEG C of vacuum drying again It is 8% to water content, crushes, cross 60 meshes, is vacuum-packed to get finished product.Finished product glycosides containing macrotin (C₂₂H₂₈O₁₁) and 5-O- first Base visamminol glycosides (C₂₂H₂₈O₁₀) total amount be 0.46%.

Claims (2)

1. a kind of radix saposhnikoviae is fresh to mention freeze-dried powder medicine materical crude slice, it is primarily characterized in that：After the harvesting of windproof medicinal material, clean in time, Impurity and the dis-medicinal part such as silt are removed, medicinal material surface wettability is kept, cleans in taking advantage of using fresh herb tap water in 24 hours and is cut into 2 1 ~ 5 times 50 ~ 70 DEG C of weight of water is added in the piece of ~ 5mm thickness, impregnates and constantly stirs 5 ~ 30 minutes, filtering, dregs pressing takes juice； The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects decoction； Merge above-mentioned decoction, cross 60 ~ 100 meshes, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is 1.15 ~ 1.25 Clear cream；After gained clear cream freezes 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, in -20 ~ -40 DEG C of vacuum freeze dryings；Lyophilized products Water content is dried under vacuum at 60 ~ 80 DEG C again lower than 12%, is crushed, 60 meshes are crossed, is vacuum-packed to get finished product；Finished product contains cimicifugae foetidae Plain glycosides (C₂₂H₂₈O₁₁) and 5-O- methyl visamminol glycosides (C₂₂H₂₈O₁₀) total amount must not be lower than 0.40%.

2. radix saposhnikoviae according to claim 1 is fresh to mention freeze-dried powder medicine materical crude slice, it is primarily characterized in that：Clinic generally uses Amount is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and can also directly enter in pill, powder, capsule and tablet.