CN108671016A - Radix Glycyrrhizae is fresh to carry freeze-dried powder medicine materical crude slice - Google Patents
Radix Glycyrrhizae is fresh to carry freeze-dried powder medicine materical crude slice Download PDFInfo
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- CN108671016A CN108671016A CN201810733242.XA CN201810733242A CN108671016A CN 108671016 A CN108671016 A CN 108671016A CN 201810733242 A CN201810733242 A CN 201810733242A CN 108671016 A CN108671016 A CN 108671016A
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- China
- Prior art keywords
- fresh
- materical crude
- medicine materical
- crude slice
- radix glycyrrhizae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of " Radix Glycyrrhizae is fresh to carry freeze-dried powder medicine materical crude slice ", are primarily characterized in that:Radix Glycyrrhizae harvest after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution is freeze-dried after being condensed into clear cream, then is vacuum-packed after crushing, being sieved.The water content of powder decoction pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of licorice piece.
Background technology
Glycyrrhiza uralensis fisch be glycyrrhizic legume, swollen fruit Radix or glycyrrhiza glabra dry root and rhizome.Radix Glycyrrhizae has tonifying spleen
QI invigorating, it is clearing heat and detoxicating, it is during frequency of use is highest in tcm clinical practice the effect of expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription
Medicine.The processing method of traditional Radix Glycyrrhizae is:It after medicinal material is excavated, directly dries/dries, bundle and package, storage and transportation.To after medicine materical crude slice factory,
It washs, soften, be sliced, dry, pack again.Such medicine materical crude slice volume is big, and Hygienic Standard is poor, is easy to make moist, is mildew, infested, no
Conducive to keeping, storage and transportation cost are high.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to ensure, clothes for patients
With inconvenience, work slow.Therefore, develop a kind of stable quality is reliable, storage/transportation is at low cost, be conducive to keeping, carry and use
Convenient, rapid-action novel licorice piece, it is imperative.Existing market licorice piece, other than traditional medicine materical crude slice, also ultra micro
Two kinds of forms of powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both using traditional medicine materical crude slice as raw material, quality is decided by traditional medicine materical crude slice
Quality, and ultramicro decoction piece cannot solve the problems, such as medicinal material pollute;Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " Radix Glycyrrhizae is fresh to carry freeze-dried powder medicine materical crude slice ", are primarily characterized in that:It is harvested in Radix Glycyrrhizae
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.15 ~ 1.25 clear cream.It is cold in -20 ~ -40 DEG C of vacuum after gained clear cream is freezed 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators
It is lyophilized dry.Lyophilized products be dried under vacuum to again at 60 ~ 80 DEG C water content be less than 10%, crush, cross 60 mesh sieve, vacuum packaging to get at
Product.Finished product medicine materical crude slice (C containing liquiritin21H22O9) 0.70% must not be less than.The clinical general usage amount of this medicine materical crude slice is 1 ~ 5g, can both enter soup
Agent decoction is taken after mixing it with water, and also can directly be entered in pill, powder, capsule and tablet, to substantially increase the convenience of Clinical practice
And compliance, be conducive to the treatment of clinical acute disease.
The present invention solve traditional licorice piece is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after licorice medicinal materials are harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature be set as 70 DEG C, be concentrated into relative density be 1.20 it is clear
Cream.By the clear cream of gained after -80 DEG C are freezed 12 hours, in -40 DEG C of vacuum freeze dryings.Dried object is dried in vacuo with 60 DEG C again
It is 8% to water content, crushes, crosses 60 mesh sieve, be vacuum-packed to get finished product.Finished product medicine materical crude slice (C containing liquiritin21H22O9) be
0.76%.
Claims (2)
1. a kind of Radix Glycyrrhizae is fresh to carry freeze-dried powder medicine materical crude slice, it is primarily characterized in that:After licorice medicinal materials harvesting, clean in time,
Impurity and the dis-medicinal part such as silt are removed, medicinal material surface wettability is kept, cleans in taking advantage of using fresh herb tap water in 24 hours and is cut into 2
The water of 1 ~ 5 times of 50 ~ 70 DEG C of weight is added in the piece of ~ 5mm thickness, impregnates and constantly stirs 5 ~ 30 minutes, filtering, dregs pressing takes juice;
The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;
Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and it is 1.15 ~ 1.25 to be concentrated into relative density
Clear cream;After gained clear cream freezes 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, in -20 ~ -40 DEG C of vacuum freeze dryings;Lyophilized products
Water content is dried under vacuum at 60 ~ 80 DEG C again and is less than 12%, is crushed, 60 mesh sieve is crossed, is vacuum-packed to get finished product;Finished product medicine materical crude slice contains
Liquiritin (C21H22O9) 0.70% must not be less than.
2. Radix Glycyrrhizae according to claim 1 is fresh to carry freeze-dried powder medicine materical crude slice, it is primarily characterized in that:Clinic generally uses
Amount is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733242.XA CN108671016A (en) | 2018-07-06 | 2018-07-06 | Radix Glycyrrhizae is fresh to carry freeze-dried powder medicine materical crude slice |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733242.XA CN108671016A (en) | 2018-07-06 | 2018-07-06 | Radix Glycyrrhizae is fresh to carry freeze-dried powder medicine materical crude slice |
Publications (1)
Publication Number | Publication Date |
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CN108671016A true CN108671016A (en) | 2018-10-19 |
Family
ID=63813448
Family Applications (1)
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CN201810733242.XA Withdrawn CN108671016A (en) | 2018-07-06 | 2018-07-06 | Radix Glycyrrhizae is fresh to carry freeze-dried powder medicine materical crude slice |
Country Status (1)
Country | Link |
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CN (1) | CN108671016A (en) |
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2018
- 2018-07-06 CN CN201810733242.XA patent/CN108671016A/en not_active Withdrawn
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PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
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WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181019 |
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