CN103055096B - Application for freeze-dried Chinese yam in medicine preparation - Google Patents
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- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
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- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
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- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
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- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to an application for freeze-dried Chinese yam in medicine preparation, which is characterized that the freeze-dried Chinese yam is applied to preparation for a medicine for tonifying spleen and nourishing stomach, promoting the secretion of saliva and reinforcing lungs, and tonifying kidney and arresting seminal emission. The freeze-dried Chinese yam represents a better curative effect than the processed products of the traditional Chinese yam in lots of experiments, and especially represents a better curative effect for tonifying spleen and nourishing stomach, promoting the secretion of saliva and reinforcing lungs, and tonifying kidney and arresting seminal emission.
Description
Technical field
The present invention relates to medicine, the particularly application of a kind of lyophilizing Rhizoma Dioscoreae in preparing medicine, belongs to medical technical field.
Background technology
Rhizoma Dioscoreae original name Rhizoma Dioscoreae is the rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.It is a kind of common vegetable, is also important simply Chinese medicine.It is medicine and tonic good merchantable brand that < < Sheng Nong's herbal classic > > records it, in China's edible history of existing more than 2000 year.< < Compendium of Materia Medica > > record Rhizoma Dioscoreae " tonify deficiency is thin, except cold and heat pathogen, invigorating middle warmer, and physical strength profiting, longue meat, reinforcing YIN-essence, takes normal hearing and eyesight for a long time, makes light of one's life by commiting suicide and prolongs life." modern study discovery; Rhizoma Dioscoreae is except containing the compositions such as crude fibre, pectin, amylase, phlegmatic temperament, glycoprotein, allantoin, saponin, batatasins, choline, dopamine, fatty acid, polysaccharide; also contain the indispensable trace element of human body such as iodine, calcium, ferrum and phosphorus; its nutritive value, medical value and disease-resistant mechanism are just progressively found and confirm, and are more and more subject to consumers in general's favor.
The processed product of tradition Rhizoma Dioscoreae has parched with bran, parching with earth, fries, Rhizoma Dioscoreae.The report that has in recent years the freezing processing method of many Rhizoma Dioscoreaes, as patent of invention 02148599.2, by Rhizoma Dioscoreae soaking sterilization in bactericidal liquid, then after peeling, cutting, Rhizoma Dioscoreae piece is soaked to color fixative again by Rhizoma Dioscoreae piece soaking sterilization in bactericidal liquid in colour-keeping liquid, then through quick-freezing, plating water glaze, then freeze manufactured goods Rhizoma Dioscoreae piece.Patent of invention 95111876.5, by fresh Rhizoma dioscoreae through cleaning, peeling, sterilizing, section, freezing vacuum dehydration, quality examination, pulverize, sieve, sterilization treatment, metering pack, sampling chemical examination, vacuum seal, packing, finished product vanning warehouse-in again.Prior art provides the method for lyophilizing Rhizoma Dioscoreae, the medicinal effects of lyophilizing Rhizoma Dioscoreae is not made targetedly and being summed up.
We find, lyophilizing Rhizoma Dioscoreae shows better curative effect than the processed product of traditional Rhizoma Dioscoreae in many tests, and the efficacy performance of particularly spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission goes out better curative effect.Evaluate the quality index of its spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission effect apparently higher than Rhizoma Dioscoreae decoction pieces.
Summary of the invention
An object of the present invention is to provide the technique of lyophilizing Rhizoma Dioscoreae.Another object of the present invention is to provide the application of lyophilizing Rhizoma Dioscoreae in preparing medicine, and feature is the application in the medicine of preparation spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.
A technique for lyophilizing Rhizoma Dioscoreae, comprises the following steps:
1) fresh Rhizoma dioscoreae raw material, removes impurity, is cut into the Rhizoma Dioscoreae section of 3-15cm;
2) by the sabot of Rhizoma Dioscoreae section, sabot weight is 5-8 ㎏/㎡, is cooled to gradually 60 ℃ of-20 ℃～– and carries out pre-freeze;
3) to be evacuated to system absolute pressure be 40～60Pa to sublimation drying, starts to be heated to 30 ℃～60 ℃, sublimation drying 15～24 hours;
4) parsing-desiccation keeps temperature of charge at 35 ℃～65 ℃, makes water content reach 2～3%, obtains lyophilizing Rhizoma Dioscoreae.
The technique of lyophilizing Rhizoma Dioscoreae of the present invention, during described sublimation drying, being evacuated to system absolute pressure is 50Pa, starts to be heated to 45 ℃～55 ℃, sublimation drying 15～20 hours.
The application of lyophilizing Rhizoma Dioscoreae in preparing medicine, feature is the application in the medicine of preparation spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission, for the preparation of strengthening immunity, defying age, antioxidant activity, antitumor, the medicine for the treatment of diabetes.
The application of the above-mentioned lyophilizing Rhizoma Dioscoreae of the present invention in preparing medicine, is directly with lyophilizing Rhizoma Dioscoreae, to pulverize, and is prepared into powder, pill.
The application of the above-mentioned lyophilizing Rhizoma Dioscoreae of the present invention in preparing medicine, is to take lyophilizing Rhizoma Dioscoreae as raw material, through extracting, with extract, is prepared into powder, granule, pill, tablet, capsule.
The application of the above-mentioned lyophilizing Rhizoma Dioscoreae of the present invention in preparing medicine, is to take lyophilizing Rhizoma Dioscoreae as raw material, and other prepared slices of Chinese crude drugs of compatibility, through extracting, are prepared into powder, granule, pill, tablet, capsule with extract.
The above-mentioned Rhizoma Dioscoreae of the present invention comprises tuber and the Bulbilus dioscoreae of Dioscoreaceae (Dioscoreaceae) plant Rhizoma Dioscoreae (DioscoreaoppositaThunb.).
The application of the above-mentioned lyophilizing Rhizoma Dioscoreae of the present invention in preparing medicine, is to take lyophilizing Rhizoma Dioscoreae to make oral formulations as raw material, takes the preparation that is equivalent to lyophilizing Rhizoma Dioscoreae 3-30g every day, minute takes for 2-3 time.
Below by test example, usefulness of the present invention is described.
Rhizoma Dioscoreae has multiple biological activity, and the polysaccharide in Rhizoma Dioscoreae is spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission main composition, has the effect that strengthens immunity, defying age, antioxidant activity, antitumor, treatment diabetes.In water-soluble extractives, contain water soluble polysaccharide, saponins, oligosaccharide, protein and aminoacid etc., be often used as the quality index of evaluating its spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission effect.
This test example adopts phenol sulfuric acid process to measure the content of polysaccharide, adopt one of < < Chinese Pharmacopoeia > > version in 2010, appendix XA method is carried out water-soluble extractives assay.Result: two component content lyophilizing Rhizoma Dioscoreaes are apparently higher than Rhizoma Dioscoreae decoction pieces.
1, preparation Rhizoma Dioscoreae decoction pieces and lyophilizing Rhizoma Dioscoreae
Get Rhizoma Dioscoreae and wash, with removing yam skin, 1. Rhizoma Dioscoreae is cut into the thin slice of 3mm left and right, put in constant temperature oven and dry to constant weight, obtain Rhizoma Dioscoreae decoction pieces; 2. be cut into the Rhizoma Dioscoreae section of length 15cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is 5-8Kg/ ㎡ left and right; Solidification point is controlled between-28～-32 ℃; Reach and control after temperature, open immediately vacuum pump and be evacuated to below drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃, and when temperature of charge and heating-up temperature approach, dry end, obtains lyophilizing Rhizoma Dioscoreae.
2, Rhizoma Dioscoreae decoction pieces and lyophilizing Rhizoma Dioscoreae water-soluble extractives, determination of polysaccharide the results are shown in following table
| ? | Water extraction content (%) | Polyoses content (%) |
| Rhizoma Dioscoreae decoction pieces | 17.26 | 5.82 |
| Lyophilizing Rhizoma Dioscoreae | 36.17 | 26.36 |
The specific embodiment
A technique for lyophilizing Rhizoma Dioscoreae, comprises the following steps:
1) fresh Rhizoma dioscoreae raw material, removes impurity, is cut into the Rhizoma Dioscoreae section of 3-15cm;
2) by the sabot of Rhizoma Dioscoreae section, sabot weight is 5-8 ㎏/㎡, is cooled to gradually 60 ℃ of-20 ℃～– and carries out pre-freeze;
3) to be evacuated to system absolute pressure be 40～60Pa to sublimation drying, starts to be heated to 30 ℃～60 ℃, sublimation drying 15～24 hours;
4) parsing-desiccation keeps temperature of charge at 35 ℃～65 ℃, makes water content reach 2～3%, obtains lyophilizing Rhizoma Dioscoreae.
The application of lyophilizing Rhizoma Dioscoreae in preparing medicine, feature is the application in the medicine of preparation spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.
The application of lyophilizing Rhizoma Dioscoreae in preparing medicine, feature is the application in the medicine of preparation spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission, for strengthening immunity, defying age, antioxidant activity, antitumor, treatment diabetes.
The application of lyophilizing Rhizoma Dioscoreae in preparing medicine, is directly with lyophilizing Rhizoma Dioscoreae, to pulverize, and is prepared into powder, pill.
The application of lyophilizing Rhizoma Dioscoreae in preparing medicine, is to take lyophilizing Rhizoma Dioscoreae as raw material, through extracting, with extract, is prepared into powder, granule, pill, tablet, capsule.
The application of lyophilizing Rhizoma Dioscoreae in preparing medicine, is to take lyophilizing Rhizoma Dioscoreae as raw material, and other prepared slices of Chinese crude drugs of compatibility, through extracting, are prepared into powder, granule, pill, tablet, capsule with extract.
The above-mentioned Rhizoma Dioscoreae of the present invention comprises tuber and the Bulbilus dioscoreae of Dioscoreaceae (Dioscoreaceae) plant Rhizoma Dioscoreae (DioscoreaoppositaThunb.).
The application of the above-mentioned lyophilizing Rhizoma Dioscoreae of the present invention in preparing medicine, is to take lyophilizing Rhizoma Dioscoreae to make oral formulations as raw material, takes the preparation that is equivalent to lyophilizing Rhizoma Dioscoreae 3-30g every day, minute takes for 2-3 time.
embodiment 1
Get new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 15cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is 5Kg/ ㎡ left and right; Solidification point is controlled at-28 ℃; Reach and control after temperature, open immediately vacuum pump and be evacuated to below drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.Make lyophilizing Rhizoma Dioscoreae.
Get lyophilizing Rhizoma Dioscoreae, pulverize, cross 80 mesh sieves, be used for the treatment of trusted subordinate's deficiency-distension, anorexia, each serving 3g, takes 2 times for 1 day, within 2 days, cures.
embodiment 2
Get new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 3cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is 8Kg/ ㎡; Solidification point is controlled between-32 ℃; Reach and control after temperature, open immediately vacuum pump and be evacuated to below drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.Make lyophilizing Rhizoma Dioscoreae.
Get lyophilizing Rhizoma Dioscoreae, pulverize, cross 80 mesh sieves, water is general is ball, is used for the treatment of frequent micturition many, every 10g that takes, and water send down, every day 3 times, within 7 days, cures.
embodiment 3
Adopt ZG-100 ㎡ type vacuum freeze drier.Choose new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 3cm, sabot, sabot weight is 7kg/ ㎡ left and right, after lowering the temperature gradually 2 hours, carries out pre-freeze to-28 ℃; Then be evacuated to system absolute pressure 40Pa, start to be heated to 35 ℃, sublimation drying 15 hours; Keep 35 ℃ of temperature of charge, when temperature of charge and heating-up temperature approach, dry end, obtains lyophilizing Rhizoma Dioscoreae again.
Get lyophilizing Rhizoma Dioscoreae powder and be broken to coarse powder, add 4 times of water gagings, at 20 ℃, stir and extract 4 hours, totally 2 times, merge extractive liquid,, filters, and centrifugal, centrifugal liquid packs freeze drying box into, lyophilizing.Obtain lyophilizing Rhizoma Dioscoreae extract.
Get Rhizoma Atractylodis Macrocephalae 1kg, Radix Ginseng 0.5 kg, uses water extraction 2 times, adds for the first time 8 times of water gagings, extract 1.5 hours, add for the second time 6 times of water gagings and extract 1 hour, merge extractive liquid,, filters, concentrated, dry, obtain the Rhizoma Atractylodis Macrocephalae, Radix Ginseng extract, add lyophilizing Rhizoma Dioscoreae extract 300g, mix, starch slurry is granulated, dry, granulate, add Pulvis Talci appropriate, tabletting, is used for the treatment of weakness of the spleen and stomach, anorexia, 12 of every days, minute 3 clothes.
embodiment 4
Get the lyophilizing Rhizoma Dioscoreae extract that embodiment 3 makes, add appropriate dextrin, granulate, reduced vacuum is dry, and granulate, is packed as 10g/ bag, obtains lyophilizing Rhizoma Dioscoreae granule, and patients with lung cancer is oral, 2 bags of every days (being equivalent to lyophilizing Rhizoma Dioscoreae 50g), minute 2 clothes.
embodiment 5
Get the lyophilizing Rhizoma Dioscoreae extract that embodiment 3 makes, add appropriate methylcellulose, granulate, reduced vacuum is dry, and granulate, incapsulates, and obtains lyophilizing Rhizoma Dioscoreae capsule, and colorectal cancer patients is oral, 15 of every days (being equivalent to lyophilizing Rhizoma Dioscoreae 15g), minute 3 clothes.
embodiment 6
Get the lyophilizing Rhizoma Dioscoreae that embodiment 1 makes and divide, add appropriate differential silica gel, pill, reduced vacuum is dry, is packed as 10g/ bag, and glycosuria patient is oral, 2 bags of every days, minute 2 clothes.
embodiment 7
Adopt ZG-100 ㎡ type vacuum freeze drier, choose new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 10cm, sabot, carries out pre-freeze to-30 ℃ after lowering the temperature gradually 2 hours; Then be evacuated to system absolute pressure 50Pa and start to be heated to 40 ℃, sublimation drying 18 hours; Keep again temperature of charge at 45 ℃, make water content reach rear discharging below 2%.Obtain lyophilizing Rhizoma Dioscoreae.
Get Radix Codonopsis 600g, Rhizoma Atractylodis Macrocephalae 600g, Poria 600g, lyophilizing Rhizoma Dioscoreae 1000g, use water extraction 2 times, add for the first time 10 times of water gagings, extract 1 hour, add for the second time 6 times of water gagings and extract 1 hour, merge extractive liquid,, filters, concentrated, dry, pulverize, add dextrin, granulate, dry, granulate, obtain granule, be used for the treatment of weakness of the spleen and stomach, lack of appetite body is tired, women leucorrhea disease, every day, 30g, divided clothes 2 times.
embodiment 8
Adopt ZG-100 ㎡ type vacuum freeze drier.Choose new fresh Rhizoma dioscoreae Bulbilus dioscoreae, clean roguing, sabot, sabot weight is 7kg/ ㎡, after lowering the temperature gradually 2 hours, carries out pre-freeze to-28 ℃; Then be evacuated to system absolute pressure 40Pa, start to be heated to 35 ℃, sublimation drying 15 hours; Keep 35 ℃ of temperature of charge, when temperature of charge and heating-up temperature approach, dry end, obtains lyophilizing Rhizoma Dioscoreae again.
Claims (1)
1. a method for the medicine of weakness of the spleen and stomach is treated in the preparation of lyophilizing Rhizoma Dioscoreae, it is characterized in that preparing by the following method:
1) choose new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 3cm, sabot, sabot weight is 7kg/ ㎡, after lowering the temperature gradually 2 hours, carries out pre-freeze to-28 ℃; Then be evacuated to system absolute pressure 40Pa, start to be heated to 35 ℃, sublimation drying 15 hours, then keep 35 ℃ of temperature of charge, dry end when temperature of charge and heating-up temperature approach, obtains lyophilizing Rhizoma Dioscoreae;
2) get lyophilizing Rhizoma Dioscoreae powder and be broken to coarse powder, add 4 times of water gagings, at 20 ℃, stir and extract 4 hours, totally 2 times, merge extractive liquid,, filters, and centrifugal, centrifugal liquid lyophilizing, obtains lyophilizing Rhizoma Dioscoreae extract;
3) get Rhizoma Atractylodis Macrocephalae 1kg, Radix Ginseng 0.5 kg, uses water extraction 2 times, add for the first time 8 times of water gagings, extract 1.5 hours, add for the second time 6 times of water gagings and extract 1 hour, merge extractive liquid,, filters, concentrated, dry, obtain the Rhizoma Atractylodis Macrocephalae, Radix Ginseng extract, add lyophilizing Rhizoma Dioscoreae extract 300g, mix, starch slurry is granulated, dry, granulate, adds Pulvis Talci appropriate, tabletting.
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| CN103478637A (en) * | 2013-08-23 | 2014-01-01 | 广西大学 | Method for preparing dried Chinese yam through vacuum freeze drying |
| CN103599322B (en) * | 2013-11-07 | 2016-08-17 | 培力(南宁)药业有限公司 | A kind of Yam dispensing granule preparation method |
| CN103652929B (en) * | 2013-12-31 | 2015-06-17 | 陈慧婷 | Sorghum and semen coicis dispersible tablet and preparation method thereof |
| CN104154713A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Lamiophlomis freeze-drying method |
| CN104165498A (en) * | 2014-08-25 | 2014-11-26 | 济南康众医药科技开发有限公司 | Scutellaria baicalensis freeze-drying method |
| CN107439869A (en) * | 2017-08-02 | 2017-12-08 | 广西壮族自治区药用植物园 | The preparation method of liquid fresh yam drink |
| CN108782909A (en) * | 2018-09-14 | 2018-11-13 | 铜川药王医都科技有限公司 | A kind of summer health care tea |
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