CN103830426B - One treats vasculitic Chinese medicine composition - Google Patents
One treats vasculitic Chinese medicine composition Download PDFInfo
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- CN103830426B CN103830426B CN201410123314.0A CN201410123314A CN103830426B CN 103830426 B CN103830426 B CN 103830426B CN 201410123314 A CN201410123314 A CN 201410123314A CN 103830426 B CN103830426 B CN 103830426B
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Abstract
The invention provides one and treat vasculitic Chinese medicine composition, it comprises the components such as Millettia Speciosa, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, Caulis Spatholobi, Herba Hedyotidis Diffusae part, Radix Zanthoxyli, Rhizoma Anemones Raddeanae.Chinese medicine preparation provided by the invention is compared with herb mixture conventional in clinical practice, and its extraction purification, preparation process combine traditional Chinese medicine theory and clinical practice requirement, and stability is better, drug effect is more guaranteed, uses more convenient.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to one and be used for the treatment of vasculitic Chinese medicine composition.
Background technology
Thromboangiitis obliterans (vasculitis) is one of peripheral arterial occlusive disease common type, that one betides the medium and small arteriovenous aseptic vascular inflammation disease of extremity, mainly involve the little medium vessels of distal limbs, nerve, especially lower limb vascular, its blood vessel wall can produce stage and nonsuppurative inflammation, normal with intracavity thrombosis, limbs can be caused and occur the disease such as pain, ischemia, interval postscript row, time serious, extremity ulcer or necrosis can be caused.Patient Duo Yin Endodontic failure is forced to amputation, disability, has a strong impact on the quality of life of patient, brings white elephant to patient home and society.Its course of disease is slow, etiology unknown, has now become one of difficult disease of capturing of current era.
The clinical remedy measures taked vasculitis has traditional remedies, operative treatment, vascular treatment methods (vasodilation art, reconstructive vascular operation), gene therapy, immunization therapy, blood purification etc. at present.All there is limitation in various degree in existing Therapeutic Method, vasculitic therapeutic effect is not satisfactory clinically.Reduce the difficult problem that such disease amputation rate caused and quality of life of improving patient becomes vascular operation treatment and the solution of internal medicine treatment urgent need.The natural resources of Chinese medicinal materials of abundant development and utilization China's abundant, selects rational medical material to study, and effectively playing Chinese medicine advantage, having important practical significance and social meaning to preventing and treating vasculitis.
Summary of the invention
The object of the invention is the technical problem for solving above, provide a kind of and effectively can treat that vasculitis, active constituent content are high, Chinese medicine composition that steady quality, patient are easy to use.
To achieve these goals, the invention provides one and treat vasculitic Chinese medicine composition, it comprises following component: Millettia Speciosa 2 weight portion, Radix Rehmanniae Preparata 2 weight portion, Radix Angelicae Sinensis 1 weight portion, Radix Achyranthis Bidentatae 1 weight portion, Caulis Spatholobi 2 weight portion, Herba Hedyotidis Diffusae 1 weight portion, Radix Zanthoxyli 1 weight portion, Rhizoma Anemones Raddeanae 1 weight portion;
And obtain according to following steps:
Step 1: get Millettia Speciosa, Radix Angelicae Sinensis, after soaking, use extraction by steam distillation volatile oil, the volatile oil beta-cyclodextrin inclusion compound of acquisition is formed volatile oil beta cyclodextrin inclusion complex, aqueous solution after distillation filters, for subsequent use, in medicinal residues, add Rhizoma Anemones Raddeanae, Caulis Spatholobi, then add alcohol reflux, filter, filtrate recycling ethanol concentrating under reduced pressure becomes clear paste A for subsequent use;
Step 2: get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, add supersound extraction after the water soaking of pH=3 ~ 4.5, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water adding pH=6 ~ 8, supersound extraction, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water adding pH=8 ~ 9 again, supersound extraction, extracting liquid filtering is for subsequent use to container; Merge the aqueous solution after the distillation of filtrate and step 1 acquisition of extracting for three times, concentrating under reduced pressure becomes clear paste B for subsequent use;
Step 3: the clear paste B that clear paste A step 1 obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, the volatile oil beta cyclodextrin inclusion complex and the proper auxiliary materials that add step 1 acquisition are prepared into granule.
Preferably, in step 1, the volume ratio for the water and medical material that soak Millettia Speciosa and Radix Angelicae Sinensis is 7:1.
Preferably, in step 1, be 4:1 for the beta-schardinger dextrin-of enclose and the volume ratio of volatile oil.
Preferably, in step 1, medicinal residues add Rhizoma Anemones Raddeanae, Caulis Spatholobi, add 60% alcohol reflux 3 times of 8 times of volumes, each 2 hours at every turn.
Preferably, in step 2, during each supersound extraction, the water added and the volume ratio of medicinal residues are 8:1.
Preferably, in step 2, during first time supersound extraction, the water soaking adding pH=3.5 carried out supersound extraction after 0.5 hour.
Preferably, in step 2, during second time supersound extraction, the water of pH=7 is added.
Preferably, in step 2, during third time supersound extraction, the water of pH=8.5 is added.
Preferably, in step 2, the time of each supersound extraction is 1 hour.
As most preferred a kind of embodiment, Chinese medicine composition of the present invention obtains according to following steps:
Step 1: get Millettia Speciosa, Radix Angelicae Sinensis, add the water soaking of 7 times of medical material volumes after 0.5 hour, distill with steam distillation and extract volatile oil in 1.5 hours, the volatile oil obtained is formed volatile oil beta cyclodextrin inclusion complex with 4 times amount beta-cyclodextrin inclusion compounds, aqueous solution after distillation filters, for subsequent use, Rhizoma Anemones Raddeanae, Caulis Spatholobi is added in medicinal residues, add 60% alcohol reflux 3 times of 8 times of volumes at every turn, each 2 hours, filter, filtrate merge after reclaim ethanol and 60 DEG C of concentrating under reduced pressure become relative density be 1.20 clear paste A for subsequent use;
Step 2: get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, the water soaking adding the pH=3.5 of 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water of the pH=7 adding 8 times of volumes, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water of the pH=8.5 adding 8 times of volumes again, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Merge three times extract filtrate and step 1 obtain distillation after aqueous solution, 60 DEG C of concentrating under reduced pressure become relative density be 1.20 clear paste B for subsequent use;
Step 3: the clear paste B that clear paste A step 1 obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, the volatile oil beta cyclodextrin inclusion complex and the proper auxiliary materials that add step 1 acquisition are prepared into granule.
Millettia Speciosa is the root of pulse family Millettia plant beautiful millettia MillettiaspecisoaChamp., and nature and flavor are sweet, flat.The lung moistening of primary efficacy tonify deficiency, strong muscle is active.
Radix Rehmanniae Preparata is that the tuber of scrophulariaceae rehmannia glutinosa plant Rehmanniaglutinosa forms through Processing methods, and nature and flavor are sweet, tepor.Return liver, kidney channel.Primary efficacy is enriched blood YIN nourishing, and beneficial essence fills out marrow.
When being classified as the dry root of umbelliferae angelica Angelicasinensis (Oliv.) Diels., nature and flavor sweet, acrid, warm.Return liver, the heart, spleen channel.Primary efficacy is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Radix Achyranthis Bidentatae is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae AchyranthesbidentataBlume., and nature and flavor are bitter, sour, flat.Return liver, kidney channel.Primary efficacy invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Caulis Spatholobi is the dry rattan of leguminous plant spatholobus suberectus (Caulis Sargentodoxae, Radix seu Caulis Verntilaginis Leiocarpae, SANYE Caulis Spatholobi, nine layers of wind) SpatholobussuberectusDunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Primary efficacy is enriched blood, and invigorates blood circulation, dredging collateral.
Herba Hedyotidis Diffusae is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae HedyotisdiffusaWilld.Nature and flavor are sweet, light, cool.Return stomach, large intestine, small intestine meridian.Primary efficacy is heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.
Radix Zanthoxyli is root or the branch and leaf of rutaceae Radix Zanthoxyli Zanthoxylumnitidum (Roxb.) DC., and nature and flavor are worked hard, and temperature is slightly poisonous.Primary efficacy dispelling wind and removing obstruction in the collateral, removing dampness to relieve pain, subduing swelling and detoxicating.
Rhizoma Anemones Raddeanae is the dry rhizome of ranunculaceae plant anemone raddeana Regel AnemoneraddeanaRegel.Nature and flavor are pungent, heat; Poisonous.Return spleen channel.Primary efficacy is wind-damp dispelling, subduing inflammation.
Chinese medicine composition of the present invention is made up of eight taste Chinese crude drugs such as Millettia Speciosa, Radix Angelicae Sinensis, Caulis Spatholobis, reasonable recipe; Wherein in Millettia Speciosa, Radix Angelicae Sinensis two taste medical material containing a large amount of volatile oil, water solublity and alcohol soluble active principals, by traditional Chinese medicine theory, Radix Angelicae Sinensis sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, invigorating middle warmer has, and having benefit in row, is key medicine in blood; Therefore its volatile ingredient should be one of main composition, therefore after first being carried out extraction by steam distillation volatile oil, and adopt beta-cyclodextrin inclusion compound, to ensure the operability of its stability and subsequent technique.Aqueous solution is continued to employ, and then medicinal residues is carried out alcohol extraction together with Rhizoma Anemones Raddeanae, Caulis Spatholobi.So both can reduce operating procedure, effective ingredient can be extracted as far as possible again.
Herba Hedyotidis Diffusae, Radix Zanthoxyli, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae four taste Chinese crude drug, its main component is respectively organic acid, alkaloid, polysaccharide, sterol etc., the present invention adopts the water of three kinds of different pH to carry out ultrasonic cryogenic extraction successively, achieve the mixed extraction of " functional component ", both ensure that the activity of functional component, decrease the precipitation of invalid impurity, play refining object.
By cold drying after above extract mixing, granule is made by existing method after adding volatile oil beta cyclodextrin inclusion complex and proper auxiliary materials, add during use after warm water is dissolved and take, easy to use, both the unstability of liquid preparation storage had been avoided, meet again " soup person swing also " of Chinese medicine, decoction is for removing the action character of serious disease.
Visible, provided by the inventionly be used for the treatment of vasculitic Chinese medicine preparation compared with herb mixture conventional in clinical practice, its extraction purification, preparation process combine traditional Chinese medicine theory and clinical practice requirement, and stability is better, drug effect is more guaranteed, uses more convenient.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is described in further detail, but protection scope of the present invention is not limited in following examples.
Embodiment 1
Each component is weighed: Millettia Speciosa 12g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 6g, Radix Achyranthis Bidentatae 6g, Caulis Spatholobi 12g, Herba Hedyotidis Diffusae 6g, Radix Zanthoxyli 6g, Rhizoma Anemones Raddeanae 6g by following formula.
Prepare Chinese medicine preparation according to the following steps:
1. get Millettia Speciosa, Radix Angelicae Sinensis, add the water soaking of 7 times of medical material volumes after 0.5 hour, distill with steam distillation and extract volatile oil in 1.5 hours, the volatile oil obtained is formed volatile oil beta cyclodextrin inclusion complex with 4 times amount beta-cyclodextrin inclusion compounds, aqueous solution after distillation filters, for subsequent use, Rhizoma Anemones Raddeanae, Caulis Spatholobi is added in medicinal residues, add 60% alcohol reflux 3 times of 8 times of volumes at every turn, each 2 hours, filter, filtrate merge after reclaim ethanol and 60 DEG C of concentrating under reduced pressure become relative density be 1.20 clear paste A for subsequent use;
2. get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, the water soaking adding the pH=3.5 of 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water of the pH=7 adding 8 times of volumes, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water of the pH=8.5 adding 8 times of volumes again, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Merge three times extract filtrate and step 1 obtain distillation after aqueous solution, 60 DEG C of concentrating under reduced pressure become relative density be 1.20 clear paste B for subsequent use;
3. the clear paste B that clear paste A step 1 obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, and the volatile oil beta cyclodextrin inclusion complex and the appropriate Icing Sugar that add step 1 acquisition are prepared into granule according to a conventional method.
Embodiment 2
Each component is weighed: Millettia Speciosa 12g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 6g, Radix Achyranthis Bidentatae 6g, Caulis Spatholobi 12g, Herba Hedyotidis Diffusae 6g, Radix Zanthoxyli 6g, Rhizoma Anemones Raddeanae 6g by following formula.
Prepare Chinese medicine preparation according to the following steps:
1. get Millettia Speciosa, Radix Angelicae Sinensis, add the water soaking of 7 times of medical material volumes after 0.5 hour, distill with steam distillation and extract volatile oil in 1.5 hours, the volatile oil obtained is formed volatile oil beta cyclodextrin inclusion complex with 4 times amount beta-cyclodextrin inclusion compounds, aqueous solution after distillation filters, for subsequent use, Rhizoma Anemones Raddeanae, Caulis Spatholobi is added in medicinal residues, add 60% alcohol reflux 3 times of 8 times of volumes at every turn, each 2 hours, filter, filtrate merge after reclaim ethanol and 60 DEG C of concentrating under reduced pressure become relative density be 1.20 clear paste A for subsequent use;
2. get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, the water soaking adding the pH=3 of 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water of the pH=6 adding 8 times of volumes, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water of the pH=9 adding 8 times of volumes again, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Merge three times extract filtrate and step 1 obtain distillation after aqueous solution, 60 DEG C of concentrating under reduced pressure become relative density be 1.20 clear paste B for subsequent use;
3. the clear paste B that clear paste A step 1 obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, and the volatile oil beta cyclodextrin inclusion complex and the appropriate Icing Sugar that add step 1 acquisition are prepared into granule according to a conventional method.
Embodiment 3
Each component is weighed: Millettia Speciosa 12g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 6g, Radix Achyranthis Bidentatae 6g, Caulis Spatholobi 12g, Herba Hedyotidis Diffusae 6g, Radix Zanthoxyli 6g, Rhizoma Anemones Raddeanae 6g by following formula.
Prepare Chinese medicine preparation according to the following steps:
1. get Millettia Speciosa, Radix Angelicae Sinensis, add the water soaking of 7 times of medical material volumes after 0.5 hour, distill with steam distillation and extract volatile oil in 1.5 hours, the volatile oil obtained is formed volatile oil beta cyclodextrin inclusion complex with 4 times amount beta-cyclodextrin inclusion compounds, aqueous solution after distillation filters, for subsequent use, Rhizoma Anemones Raddeanae, Caulis Spatholobi is added in medicinal residues, add 60% alcohol reflux 3 times of 8 times of volumes at every turn, each 2 hours, filter, filtrate merge after reclaim ethanol and 60 DEG C of concentrating under reduced pressure become relative density be 1.20 clear paste A for subsequent use;
2. get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, the water soaking adding the pH=4.5 of 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water of the pH=8 adding 8 times of volumes, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water of the pH=8 adding 8 times of volumes again, supersound extraction 1 hour, extracting liquid filtering is for subsequent use to container; Merge three times extract filtrate and step 1 obtain distillation after aqueous solution, 60 DEG C of concentrating under reduced pressure become relative density be 1.20 clear paste B for subsequent use;
3. the clear paste B that clear paste A step 1 obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, and the volatile oil beta cyclodextrin inclusion complex and the appropriate Icing Sugar that add step 1 acquisition are prepared into granule according to a conventional method.
Comparative example (mixture)
Soak by water preparation technology routinely, take Millettia Speciosa 12g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 6g, Radix Achyranthis Bidentatae 6g, Caulis Spatholobi 12g, Herba Hedyotidis Diffusae 6g, Radix Zanthoxyli 6g, Rhizoma Anemones Raddeanae 6g, add appropriate water boiling and extraction 3 times, each 1.5 hours, merge 3 extracting solution, filter, filtrate reduced in volume is the concentrated solution of 0.66g/ml to containing crude drug amount, fill, sterilizing, to obtain final product.
Functional component assay and stability study:
The mixture obtain comparative example and the granule obtained by embodiment 1 ~ 3 carry out active constituent content measuring and stability study, so that the Advantageous Effects that the present invention reaches to be described.
1. the active constituent content of high effective liquid chromatography for measuring sample:
(1) active constituent content measuring of the granule sample of embodiment 1 ~ 3: with 5 hydroxymethyl furfural, ferulic acid, catalpol, formononetin, Raddeanin A, ecdysterone, woodruff acid, nitidine chloride for reference substance, octadecylsilane chemically bonded silica is filler, with acetonitrile-water (0.1% phosphoric acid) for mobile phase, gradient elution, full wavelength detecting; Take granule 0.5g, accurately weighed, be placed in conical flask, add 50ml methanol, supersound extraction 30 minutes, taking-up lets cool, and filters, uses methanol wash residue, and filtrate moves into 50ml volumetric flask, by methanol constant volume to 50ml, shakes up; Accurate absorption 20 μ l need testing solution injection liquid chromatographies, measure, to obtain final product.
(2) active constituent content measuring of comparative example mixture sample: with 5 hydroxymethyl furfural, ferulic acid, catalpol, formononetin, Raddeanin A, ecdysterone, woodruff acid, nitidine chloride for reference substance, octadecylsilane chemically bonded silica is filler, with acetonitrile-water (0.1% phosphoric acid) for mobile phase, gradient elution, full wavelength detecting; Accurate absorption mixture 10ml, be placed in evaporating dish, water bath method, add 40ml methanol, supersound extraction 30 minutes, taking-up lets cool, and filters, uses methanol wash residue, and filtrate moves into 50ml volumetric flask, by methanol constant volume to 50ml, shakes up; Accurate absorption 20 μ l need testing solution injection liquid chromatographies, measure, to obtain final product.
2. gas chromatography determination volatile component content:
(1) the granule sample of embodiment 1 ~ 3: take australene as reference substance, capillary chromatographic column, headspace sampling, injector temperature 240 DEG C, detector temperature is 260 DEG C, and carrier gas is helium; Precision takes 1.0g sample, adds water dissolution, and ultrasonic 30 minutes, water was settled to 50ml, proceeds to headspace sampling bottle, jump a queue after shaking up, and put into head-space sampler auto injection, mensuration, to obtain final product.
(2) comparative example mixture sample: take australene as reference substance, capillary chromatographic column, headspace sampling, injector temperature 240 DEG C, detector temperature is 260 DEG C, and carrier gas is helium; Accurate absorption mixture 10ml, water is settled to 50ml, proceeds to headspace sampling bottle, jump a queue after shaking up, and puts into head-space sampler auto injection, mensuration, to obtain final product.
3. sample stability research:
(1) the granule sample of embodiment 1 ~ 3: granule sample is enclosed conventional granulates agent complex pocket, prepare 3 batches, carry out room temperature by the method for " Chinese Pharmacopoeia " annex stability study guideline to keep sample for a long time test, respectively in outward appearance, the character of 0,3,6 month observation preparation.
(2) comparative example mixture sample: get 3 batches of mixture samples and carry out room temperature by the method for " Chinese Pharmacopoeia " annex stability study guideline and to keep sample for a long time test, observed outward appearance, the character of preparation respectively at 0,3,6 month.
4. result of study:
After measured, the active constituent content of each sample is as shown in table 1, table 2:
Table 1 high effective liquid chromatography for measuring active constituent content (μ g/g)
Table 2 gas chromatography measures volatile component content
| Sample | Batch | Australene content (μ g/g) |
| Embodiment 1 | 5 | 1.3 |
| Embodiment 2 | 5 | 1.1 |
| Embodiment 3 | 5 | 1.2 |
| Comparative example mixture | 5 | 0.2 |
As seen from the above table, preparation of the present invention is compared with common mixture, and active constituent content is high, and drug effect is better.
In addition, through long-term reserved sample observing, after comparative example mixture storage of samples, precipitation is engendered, color burn; And the granule sample of the embodiment of the present invention 1 ~ 3 without occurring hardening, metachromatism, stability significantly improves.
The test of pesticide effectiveness
Clarify a diagnosis about the diagnostic criteria of superficial thrombophlebitis according in " peripheral vascular disease Chinese and western medicine diagnostics ".Outpatient service and inpatient be totally 200 examples, wherein extremity superficial thrombophlebitis 100 example, migrans superficial thrombophlebitis 40 example, breast stomach wall superficial thrombophlebitis 60 example, age 20 ~ 65, man 120 example, female 80 example.Be divided into two groups at random.Wherein treatment group 100 example, matched group 100 example, between two groups, the physical data such as age, the course of disease, the state of an illness is through inspection no significant difference.
Therapeutic Method
Matched group: acute stage gives oral aspirin, antibiotics, nonsteroidal antiinflammatory drug, vitamin C, compound recipe bromelain sheet etc., and chronic phase gives In Rutin Compound Tablets, Radix Notoginseng total glucosides tablet etc.
Treatment group: add on the basis of matched group and take after mixing it with water with embodiment 1 ~ 3 gained Chinese medicine preparation warm water, each 5g, every day 2 times; 15d is 1 course for the treatment of, carries out the next course for the treatment of after the 5d of interval.
Criterion of therapeutical effect: formulate with reference to " peripheral vascular disease Chinese and western medicine diagnostics ".Recovery from illness: local red and swollen heat pain and hard rope bar disappear, and non-pigment is calm, and body temperature and leukocyte recover normal, without recurrence in 1 year; Effective: disappearance of swelling and ache, rope bar does not absorb completely, has pigmentation, without recurrence in half a year; Effective: to swell and ache and alleviate, have tenderness, rope bar exists, without reducing; Invalid: above symptom and sign is without change, or recurrent exerbation.Therapeutic outcome is in table 3.
Table 3 is the rear comparitive study of group treatment respectively
Visible, in each course of disease group, treatment group total effective rate is up to 98%, and its curative effect is obviously better than matched group, and the course of disease is shorter, and curative effect is better.
Claims (9)
1. treat a vasculitic Chinese medicine composition, it is characterized in that being made up of the raw material of following weight portion: Millettia Speciosa 2 weight portion, Radix Rehmanniae Preparata 2 weight portion, Radix Angelicae Sinensis 1 weight portion, Radix Achyranthis Bidentatae 1 weight portion, Caulis Spatholobi 2 weight portion, Herba Hedyotidis Diffusae 1 weight portion, Radix Zanthoxyli 1 weight portion, Rhizoma Anemones Raddeanae 1 weight portion;
And obtain according to following steps:
Step 1: get Millettia Speciosa, Radix Angelicae Sinensis, after soaking, use extraction by steam distillation volatile oil, the volatile oil beta-cyclodextrin inclusion compound of acquisition is formed volatile oil beta cyclodextrin inclusion complex, aqueous solution after distillation filters, for subsequent use, in medicinal residues, add Rhizoma Anemones Raddeanae, Caulis Spatholobi, then add alcohol reflux, filter, filtrate recycling ethanol concentrating under reduced pressure becomes clear paste A for subsequent use;
Step 2: get Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Herba Hedyotidis Diffusae, Radix Zanthoxyli, add supersound extraction after the water soaking of pH=3 ~ 4.5, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water adding pH=6 ~ 8, supersound extraction, extracting liquid filtering is for subsequent use to container; In medicinal residues, continue the water adding pH=8 ~ 9 again, supersound extraction, extracting liquid filtering is for subsequent use to container; Merge the aqueous solution after the distillation of filtrate and step 1 acquisition of extracting for three times, concentrating under reduced pressure becomes clear paste B for subsequent use;
Step 3: the clear paste B that clear paste A step 1 obtained and step 2 obtain mixes, and vacuum dehydrating at lower temperature, is ground into fine powder, the volatile oil beta cyclodextrin inclusion complex and the proper auxiliary materials that add step 1 acquisition are prepared into granule.
2. Chinese medicine composition according to claim 1, is characterized in that: in step 1, and the volume ratio for the water and medical material that soak Millettia Speciosa and Radix Angelicae Sinensis is 7:1.
3. Chinese medicine composition according to claim 1, is characterized in that: in step 1, is 4:1 for the beta-schardinger dextrin-of enclose and the volume ratio of volatile oil.
4. Chinese medicine composition according to claim 1, is characterized in that: in step 1, medicinal residues add Rhizoma Anemones Raddeanae, Caulis Spatholobi, adds 60% alcohol reflux 3 times of 8 times of volumes, each 2 hours at every turn.
5. Chinese medicine composition according to claim 1, is characterized in that: in step 2, and during each supersound extraction, the water added and the volume ratio of medicinal residues are 8:1.
6. Chinese medicine composition according to claim 1, is characterized in that: in step 2, and during first time supersound extraction, the water soaking adding pH=3.5 carried out supersound extraction after 0.5 hour.
7. Chinese medicine composition according to claim 1, is characterized in that: in step 2, during second time supersound extraction, adds the water of pH=7.
8. Chinese medicine composition according to claim 1, is characterized in that: in step 2, during third time supersound extraction, adds the water of pH=8.5.
9. Chinese medicine composition according to claim 1, is characterized in that: in step 2, and the time of each supersound extraction is 1 hour.
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