CN102133273B - Traditional Chinese medicine lipid-lowing and catharsis capsule and preparation method thereof - Google Patents
Traditional Chinese medicine lipid-lowing and catharsis capsule and preparation method thereof Download PDFInfo
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- CN102133273B CN102133273B CN2011100411486A CN201110041148A CN102133273B CN 102133273 B CN102133273 B CN 102133273B CN 2011100411486 A CN2011100411486 A CN 2011100411486A CN 201110041148 A CN201110041148 A CN 201110041148A CN 102133273 B CN102133273 B CN 102133273B
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Abstract
The invention discloses a novel traditional Chinese medicine lipid-lowing and aperient capsule and a preparation method thereof, and belongs to the field of traditional Chinese medicines. Rhubarb, weathered sodium sulfate, ginseng, lucid ganoderma, cinnamon and liquoric root are taken as raw materials, and are combined according to different pharmacological properties and physicochemical properties of active ingredients of the traditional Chinese medicines in a certain ratio to be prepared into a clinical medicinal formulation. The Chinese medicinal composition is clinically used for diseases such as hyperlipidemia, constipation, abdominal distention and anorexia, obesity and the like caused by gastrointestinal excess heat and spleen-Qi deficiency, the total effective rate for treating the hyperlipemia is 97.8 percent, and the total recovery rate and the effective rate for treating habitual constipation are 100 percent.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, belong to the field of Chinese medicines, be specifically related to a kind of Chinese medicine blood fat reducing relieving constipation capsule and preparation method thereof.
Background technology
Constipation is a kind of commonly encountered diseases; Not a kind of disease of especially severe outwardly; But in fact, had a strong impact on outside quality of life, also can not in time discharge because of the refuse in the intestinal except bring huge misery and worry to the patient; Cause a large amount of noxious substances in intestinal, to accumulate for a long time, thereby bring out a series of other diseases.In addition, for hepatopath, hyperpietic, because constipation Overexertion when making defecation, serious life-threatening burst accident such as bring out that arteries breaks easily.So constipation is an immeasurable serious disease.The medicine that is used at present to treat constipation clinically has osmotic laxative, irritant laxative, emollient laxative, permeability caccagogue etc., though certain effect is all arranged, is mostly to cure the symptoms, not the disease, even causes some side effect.So still need research and develop more safe and effective relieving constipation medicine.
Hyperlipidemia also is a kind of very harmful commonly encountered diseases, is the main cause of bringing out cardio cerebrovascular affection, and sickness rate is high.The big toxic and side effects of the medicine ubiquity that uses clinically at present.
Chinese medicine is the national treasure of China, in secular medical practice, has accumulated the experience of many treatment constipation, has obtained effect preferably.Say that from theory of Chinese medical science the constipation majority is owing to gastrointestinal excess-heat, temper are lost due to the void, adopts the Chinese medicine composition of the QI invigorating of reducing phlegm and internal heat to nurse one's health, and can fundamentally treat constipation, the achievement that the present invention obtains from this exploration just.
Summary of the invention
The object of the invention is to provide a kind of can fundamentally treat hyperlipidemia, constipation, and the Chinese medicine composition that has no side effect; Another purpose is to provide its preparation method.
Be to realize the object of the invention, it is that preparation of raw material forms that the present invention selects following Chinese medicine component for use, and each component is in weight portion:
Radix Et Rhizoma Rhei 32---50 parts of 320 parts of Matrii Sulfas Exsiccatus 8---80 parts of Radix Ginsengs 5---
Ganoderma 1---75 parts of 10 portions of Cortex Cinnamomis 2.5---25 portions of Radix Glycyrrhizaes 7.5---.
Above component is preferred:
15 parts in 5 portions of Radix Glycyrrhizaes of 2 portions of Cortex Cinnamomis of 10 portions of Ganodermas of 16 parts of Radix Ginsengs of 64 parts of Matrii Sulfas Exsiccatus of Radix Et Rhizoma Rhei.
In the Chinese medicine composition according to the invention, per 0.5 gram contains Radix Et Rhizoma Rhei with emodin (C
15H
10O
5) and chrysophanol (C
15H
10O
4) the total amount meter, must not be less than 2.70 milligrams.Per 0.5 gram contains Radix Ginseng with the ginsenoside Rg in the said Chinese medicine composition
1Be no less than 0.17 milligram with ginsenoside Re's total amount meter.Per 0.5 gram glycyrrhizic acid content is no less than 6.0 milligrams in the said Chinese medicine composition.Radix Et Rhizoma Rhei, ginsenoside Rg
1With the assay method of ginsenoside Re, glycyrrhizic acid be high-efficient liquid phase technique.
Chinese medicine composition according to the invention prepares through following method:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 6-10 times of water gagings, supersound extraction, filter cleaner, the filtrate decompression vacuum concentration gets thick paste, drying is pulverized, sieve fine powder; Get the formula ratio Radix Et Rhizoma Rhei, add its 6-10 times amount ethanol, supersound extraction, filter cleaner is concentrated near doing, and drying is pulverized, and sieves, and it is subsequent use to get emodin and chrysophanol fine powder; Get recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi respectively roguing pulverize, sieve to such an extent that Matrii Sulfas Exsiccatus and Cortex Cinnamomi fine powder are subsequent use; Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively; With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds magnesium stearate, processes capsule or tablet.
This Chinese medicine composition of the present invention has purging heat to relax the bowels, invigorating the spleen and benefiting QI function; Be used for the intestines and stomach excess-heat, temper clinically and lose diseases such as hyperlipidemia due to the void, constipation, abdominal distension and anorexia, obesity; Can fundamentally treat constipation, and have no side effect, have the good clinical effect; Treatment hyperlipidemia total effective rate reaches 97.8%, treatment total cure rate of habitual constipation and obvious effective rate 100%.
The specific embodiment
Following for the present invention better being explained act embodiment:
Embodiment 1
Choose: 64 parts of Radix Et Rhizoma Rhei, 16 parts of Matrii Sulfas Exsiccatus, 10 parts of Radix Ginsengs, 2 parts of Ganodermas, 5 parts of Cortex Cinnamomis, Radix Glycyrrhizae is Chinese medicine composition raw material of the present invention for 15 parts.Method for preparing is following:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 10 times of water gagings; 50 ℃ of supersound extraction 60 minutes (ultrasonic power 50W, supersonic frequency 30KHz), filter cleaner; The filtrate decompression vacuum concentration, vacuum ﹣ 0.08Mpa, temperature gets thick paste for 60 ℃; 75-85 ℃ of dryings are pulverized, and cross 160 mesh sieves and get fine powder.Get the formula ratio Radix Et Rhizoma Rhei, add its 10 times amount ethanol, 70 ℃ of supersound extraction 2 hours (ultrasonic power 50W, supersonic frequency 30KHZ); Filter and remove residue, the 60 ℃ of normal pressures of filtrating are concentrated near dried, 60-65 ℃ of dryings of solids; Pulverize, cross 160 mesh sieves, it is subsequent use to get emodin and chrysophanol fine powder.
Get recipe quantity Matrii Sulfas Exsiccatus and Cortex Cinnamomi and distinguish the roguing pulverizing, it is subsequent use that mistake 80 mesh sieves get the Matrii Sulfas Exsiccatus fine powder.Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively.With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds Chinese medicine gross weight 1% magnesium stearate, processes the capsule of 0.5 gram/grain, packing.
Contain emodin with emodin (C in this product every (0.5 gram)
15H
10O
5) and chrysophanol (C
15H
10O
4) total amount be no less than 2.70 milligrams.
Radix Et Rhizoma Rhei Determination on content method is a high-efficient liquid phase technique:
Chromatographic condition and system suitability test: use octadecylsilane chemically bonded silica to be filler; Methanol-0.1% phosphoric acid solution (88:12) is a mobile phase; The detection wavelength is 254nm, and number of theoretical plate calculates by the emodin peak should be not less than 3500.
The preparation of reference substance solution: precision takes by weighing emodin, each 10mg of chrysophanol reference substance, puts respectively in the 50ml measuring bottle, with dissolve with methanol and be diluted to scale, shakes up; Precision is measured emodin solution 1ml, chrysophanol solution 2ml respectively, puts respectively in the same 250ml measuring bottle, adds methanol to scale, shakes up, and promptly gets (contain among the every 1ml of emodin among 8 μ g, the every 1ml of chrysophanol and contain 16 μ g).
The preparation of need testing solution: get the content under these article quantity variance item, mixing is got 0.2g, and accurate the title decides, and puts in the tool plug conical flask, the accurate methanol 25ml that adds; Close plug is claimed decide weight, and reflux 30 minutes is put coldly, and weight decided in title again, supplies the weight that subtracts mistake with methanol; Shake up, filter, precision is measured filtrating 5ml, puts in the round-bottomed flask, flings to methanol, adds the 2.5mol/L sulfuric acid solution; Supersound process 5 minutes adds chloroform 10ml again, reflux 1 hour, and cooling in the dislocation separatory funnel, is used the minimum of chloroform washing container; Washing liquid is incorporated in the separatory funnel, obtains chloroform layer, and acid solution is with chloroform extraction 2 times, each 8ml, and combined chloroform liquid dewaters with anhydrous sodium sulfate in right amount; In the chloroform solution dislocation tool plug conical flask, fling to chloroform, the accurate methanol 10ml that adds of residue claims to decide weight, puts slight fever dissolved residue in the water-bath, put cold after; Claim again to decide weight, supply the weight that subtracts mistake, shake up, filter, get subsequent filtrate, promptly get with methanol.
Algoscopy: accurate respectively reference substance solution and each 20 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, promptly get.
Per 0.5 gram contains the ginsenoside Rg in this product
1(C
42H
72O
14) and ginsenoside Re (C
48H
82O
18) total amount be no less than 0.17 milligram.
The ginsenoside Rg
1With ginsenoside Re's assay method be high-efficient liquid phase technique:
Chromatographic condition and system suitability test: with the octadecylsilane chemically bonded silica is filler; With the acetonitrile is mobile phase A, is Mobile phase B with water, and the regulation in the according to the form below is carried out gradient elution; The detection wavelength is 203nm.Number of theoretical plate is by the ginsenoside Rg
1The peak calculates should be not less than 6000.
The preparation of reference substance solution: precision takes by weighing the ginsenoside Rg
1Reference substance, ginsenoside Re's reference substance add methanol and process the mixed solution that every 1ml contains 0.2mg, shake up, and promptly get.
The preparation of need testing solution: get the about 1g of these article powder (crossing sieve No. four), the accurate title, decide, and puts in the apparatus,Soxhlet's, added the chloroform reflux 3 hours, discards chloroform liquid; Medicinal residues volatilize solvent, move in the 100ml conical flask together with filtration paper cylinder, and precision adds water-saturated n-butanol 50ml, close plug, and placement is spent the night; Supersound process (power 250W, frequency 50Khz) 30 minutes filters, and discards filtrating just; Precision is measured subsequent filtrate 25ml, puts evaporate to dryness in the evaporating dish, and residue adds dissolve with methanol and is transferred in the 5ml measuring bottle, adds methanol and is diluted to scale; Shake up, filter, get subsequent filtrate, promptly get.
Algoscopy: the accurate respectively reference substance solution 10 μ l that draw, inject chromatograph of liquid, measure, promptly get.
The per 0.5 gram glycyrrhizic acid (C of this product
21H
22O
2) content must not be less than 6.0 milligrams.
The glycyrrhizic acid content assay method is a high-efficient liquid phase technique:
Chromatographic condition and system suitability test: with the octadecylsilane chemically bonded silica is filler; With the acetonitrile is mobile phase A, is Mobile phase B with 0.05% phosphoric acid solution, and the regulation in the according to the form below is carried out gradient elution; The detection wavelength is 237nm.Number of theoretical plate calculates by the liquirtin peak should be not less than 5000.
The preparation of reference substance solution: extracting liquorice acid ammonium reference substance is an amount of, and accurate the title decides, and adds 70% ethanol and processes the solution that every 1ml contains ammonium glycyrrhizinate 0.2mg respectively, promptly gets (glycyrrhizic acid weight=ammonium glycyrrhizinate weight/1.0207).
The preparation of need testing solution: get the about 0.2g of these article powder (crossing sieve No. three), the accurate title, decide, and puts in the tool plug conical flask, the accurate 70% ethanol 100ml that adds; Close plug claims to decide weight, supersound process (power 250W, frequency 40Khz) 30 minutes; Put coldly, claim again to decide weight, supply the weight that subtracts mistake, shake up with 70% ethanol; Filter, get subsequent filtrate, promptly get.
Algoscopy: accurate respectively reference substance solution and each 10 μ l of confession test agent solution of drawing, inject chromatograph of liquid, measure, promptly get.
Embodiment 2
Choose: 168 parts of Radix Et Rhizoma Rhei, 30 parts of Matrii Sulfas Exsiccatus, 20 parts of Radix Ginsengs, 5 parts of Ganodermas, 25 parts of Cortex Cinnamomis, 30 parts in Radix Glycyrrhizae is Chinese medicine composition raw material of the present invention.Method for preparing is following:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 8 times of water gagings; 50 ℃ of supersound extraction 80 minutes (ultrasonic power 50W, supersonic frequency 30KHz), filter cleaner; The filtrate decompression vacuum concentration, vacuum ﹣ 0.06Mpa, temperature gets thick paste for 70 ℃; 75-85 ℃ of dryings are pulverized, and cross 160 mesh sieves and get fine powder.Get the formula ratio Radix Et Rhizoma Rhei, add its 8 times amount ethanol, 60 ℃ of supersound extraction 3 hours (ultrasonic power 50W, supersonic frequency 30KHZ); Filter and remove residue, the 65 ℃ of normal pressures of filtrating are concentrated near dried, 60-65 ℃ of dryings; Pulverize, cross 160 mesh sieves, it is subsequent use to get emodin and chrysophanol fine powder.
Get the roguing pulverizing respectively of recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi, mistake 80 mesh sieves get Matrii Sulfas Exsiccatus and the Cortex Cinnamomi fine powder is subsequent use.Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively.With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds the magnesium stearate of Chinese medicine gross weight 1%, processes the capsule of 0.5 gram/grain, packing.
Contain emodin with emodin (C in per 0.5 gram of this product
15H
10O
5) and chrysophanol (C
15H
10O
4) total amount be no less than 2.70 milligrams.Contain the ginsenoside Rg
1(C
42H
72O
14) and ginsenoside Re (C
48H
82O
18) total amount be no less than 0.17 milligram.Glycyrrhizic acid (C
21H
22O
2) content is no less than 6.0 milligrams.
Assay method is with embodiment 1.
Embodiment 3
Choose: 200 parts of Radix Et Rhizoma Rhei, 24 parts of Matrii Sulfas Exsiccatus, 16 parts of Radix Ginsengs, 3.5 parts of Ganodermas, 10 parts of Cortex Cinnamomis, 23 parts in Radix Glycyrrhizae is Chinese medicine composition raw material of the present invention.Method for preparing is following:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 6 times of water gagings; 50 ℃ of supersound extraction 120 minutes (ultrasonic power 50W, supersonic frequency 30KHz), filter cleaner; The filtrate decompression vacuum concentration, vacuum ﹣ 0.065Mpa, temperature gets thick paste for 60-70 ℃; 75-85 ℃ of dryings are pulverized, and cross 160 mesh sieves and get fine powder.Get the formula ratio Radix Et Rhizoma Rhei, add its 6 times amount ethanol, 55 ℃ of supersound extraction 4 hours (ultrasonic power 50W, supersonic frequency 30KHZ); Filter and remove residue, the 65 ℃ of normal pressures of filtrating are concentrated near dried, 60-65 ℃ of dryings; Pulverize, cross 160 mesh sieves, it is subsequent use to get emodin and chrysophanol fine powder.
Get the roguing pulverizing respectively of recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi, 80 mesh sieves get Matrii Sulfas Exsiccatus excessively, the Cortex Cinnamomi fine powder is subsequent use.Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively.With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds 1% magnesium stearate of Chinese medicine gross weight, processes the tablet of 0.5 gram/grain, packing.
Contain emodin with emodin (C in per 0.5 gram of this product
15H
10O
5) and chrysophanol (C
15H
10O
4) total amount be no less than 2.70 milligrams.Contain the ginsenoside Rg
1(C
42H
72O
14) and ginsenoside Re (C
48H
82O
18) total amount be no less than 0.17 milligram.Glycyrrhizic acid (C
21H
22O
2) content is no less than 6.0 milligrams.
Assay method is with embodiment 1.
Embodiment 4
Choose: 240 parts of Radix Et Rhizoma Rhei, 64 parts of Matrii Sulfas Exsiccatus, 40 parts of Radix Ginsengs, 5.5 parts of Ganodermas, 20 parts of Cortex Cinnamomis, 60 parts in Radix Glycyrrhizae is Chinese medicine composition raw material of the present invention.Method for preparing is following:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 8 times of water gagings; 50 ℃ of supersound extraction 100 minutes (ultrasonic power 50W, supersonic frequency 30KHz), filter cleaner; The filtrate decompression vacuum concentration, vacuum ﹣ 0.07Mpa, temperature gets thick paste for 65-75 ℃; 75-85 ℃ of dryings are pulverized, and cross 160 mesh sieves and get fine powder.Get the formula ratio Radix Et Rhizoma Rhei, add its 8 times amount ethanol, 70 ℃ of supersound extraction 2 hours (ultrasonic power 50W, supersonic frequency 30KHZ); Filter and remove residue is filtrated 50 ℃ to be evaporated to closely and is done 60-65 ℃ of dryings; Pulverize, cross 160 mesh sieves, it is subsequent use to get emodin and chrysophanol fine powder.
Get the roguing pulverizing respectively of recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi, mistake 80 mesh sieves get Matrii Sulfas Exsiccatus and the Cortex Cinnamomi fine powder is subsequent use.Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively.With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds the magnesium stearate of Chinese medicine gross weight 1%, processes the capsule of 0.5 gram/grain, packing.
Contain emodin with emodin (C in per 0.5 gram of this product
15H
10O
5) and chrysophanol (C
15H
10O
4) total amount be no less than 2.70 milligrams.Contain the ginsenoside Rg
1(C
42H
72O
14) and ginsenoside Re (C
48H
82O
18) total amount be no less than 0.17 milligram.Glycyrrhizic acid (C
21H
22O
2) content is no less than 6.0 milligrams.
Assay method is with embodiment 1.
Embodiment 5
Choose: 190 parts of Radix Et Rhizoma Rhei, 48 parts of Matrii Sulfas Exsiccatus, 30 parts of Radix Ginsengs, 6 parts of Ganodermas, 15 parts of Cortex Cinnamomis, 45 parts in Radix Glycyrrhizae is Chinese medicine composition raw material of the present invention.Method for preparing is following:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 10 times of water gagings; 50 ℃ of supersound extraction 70 minutes (ultrasonic power 50W, supersonic frequency 30KHz), filter cleaner; The filtrate decompression vacuum concentration, vacuum ﹣ 0.065Mpa, temperature gets thick paste for 70-80 ℃; 75-85 ℃ of dryings are pulverized, and cross 160 mesh sieves and get fine powder.Get the formula ratio Radix Et Rhizoma Rhei, add 7 times of amount ethanol, 65 ℃ of supersound extraction 3.5 hours (ultrasonic power 50W, supersonic frequency 30KHZ); Filter and remove residue is filtrated 55 ℃ to be evaporated to closely and is done 60-65 ℃ of dryings; Pulverize, cross 160 mesh sieves, it is subsequent use to get emodin and chrysophanol fine powder.
Get the roguing pulverizing respectively of recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi, mistake 80 mesh sieves get Matrii Sulfas Exsiccatus and the Cortex Cinnamomi fine powder is subsequent use.Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively.With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds the magnesium stearate of Chinese medicine gross weight 1%, processes the coated tablet of 0.25 gram/grain, packing.
Contain emodin with emodin (C in per 0.5 gram of this product
15H
10O
5) and chrysophanol (C
15H
10O
4) total amount must not be less than 2.70 milligrams.Contain the ginsenoside Rg
1(C
42H
72O
14) and ginsenoside Re (C
48H
82O
18) total amount be no less than 0.17 milligram.Glycyrrhizic acid (C
21H
22O
2) content is no less than 6.0 milligrams.
Assay method is with embodiment 1.
Chinese medicine composition blood fat reducing relieving constipation capsule according to the invention (pharmaceutical formulation: capsule, every 0.5g) clinical test results is following:
Treatment hyperlipidemia clinical test results:
Case is selected:
Select case 360 examples altogether, 120 examples of wherein being in hospital, non-140 examples of being in hospital.In selected case, male's 220 examples, women's 140 examples, minimum 36 years old of age, maximum 68 years old, 52 years old mean age.
Therapeutic Method: oral, each 6, each once serve on five days sooner or later, and according to clinical symptoms adjustment dosage, 4 weeks were a course of treatment, added up curative effect after the course of treatment after five days.
Curative effect observation: blood fat is measured in blood drawing.
Clinical development standard: with reference to the hyperlipidemia criterion of therapeutical effect of regulation in " People's Republic of China's traditional Chinese medical science industry standard disease of tcm diagnosis criterion of therapeutical effect " (State Administration of Traditional Chinese Medicine's in June, 1994 issue).
Clinical test results:
Treatment constipation clinical test results:
Case is selected:
Select case 300 examples altogether, 61 examples of wherein being in hospital, non-239 examples of being in hospital.In the selected case, male's 180 examples, women's 120 examples, minimum 36 years old of age, maximum 72 years old, 59 years old mean age.
Therapeutic Method: oral, each 6, one day 2 times, 1 week was a course of treatment, according to clinical symptoms adjustment dosage, added up curative effect after the course of treatment.
Curative effect observation: defecation frequency, defecation time, just matter first, defecation effort situation, Asiatic water closet pan time.
Clinical development standard: with reference to the constipation criterion of therapeutical effect of regulation in " People's Republic of China's traditional Chinese medical science industry standard disease of tcm diagnosis criterion of therapeutical effect " (State Administration of Traditional Chinese Medicine's in June, 1994 issue).
Clinical test results:
Effective case 290 examples, result such as following table:
Model case:
1, Chen, the man, 52 years old, the cadre, dizziness, tired, abdominal distention is month surplus, health check-up: refreshing clear, obesity, cardiopulmonary are no abnormal, and abdominal distention is and soft, and liver, palpation of spleen are not noted, BP15/10.5Kpa, red tongue, moist and slippery fur is greasy, arteries and veins bone number.The three fat TC6.4mmol/L that have a blood test, TG2.9 mmol/L, HDL-C0.52 mmol/L, diagnosis: hyperlipemia (Chinese medical discrimination: expectorant is turbid to be checked), take blood fat reducing relieving constipation capsule, each 6; Every day 2 times, ante cibum, each was obeyed once sooner or later, second day, defecated the abdomen hypodynia 5 times; Advise its decrement, beginning in the 3rd day, each 3, every day 2 times, early, took medicine in one hour after the supper; Stool is multiple normal, and stomachache disappears, and around serveing on, above-mentioned symptom obviously alleviates, check blood fat TC5.6mmol/L; TG1.7 mmol/L, HDL-C1.1 mmol/L, thin white fur of tongue, stringy pulse is slow, reaches the clinic control standard.
2, what certain, the man, 63 years old, the cadre because of recurrent dizziness 2 years, increased the weight of two days, after being in hospital, had a medical check-up: refreshing clear, swallow red, heart rate 82 times/minute, A
2＞P
2, two lungs are no abnormal, and abdomen is soft, 0.5cm under the liver rib.The fat TC6.5mmol/L that has a blood test, TG7.29 mmol/L, HDL-C1.85 mmol/L promptly takes blood fat reducing relieving constipation capsule; Every day 2 times, each 6, change every day 1 time after 5 days into, serve on for 4 weeks; Dizziness, Mental fatigue, numb limbs and tense tendons obviously improves, and fat TC3.5mmol/L has a blood test; TG1.51 mmol/L, HDL-C2.6 mmol/L reaches the clinic control standard.
3, Ke so-and-so, woman, 53 years old, teacher.Time sense is dizzy, numb limbs and tense tendons and sleeping not good enough 2 years, and often have constipation or defecation not smooth.Health check-up: the fat bodily form, BP20/12.5Kpa, heart rate 74 times/minute, rule is whole, no pathologic noise, two lungs are clear, and abdomen is flat soft, and the liver spleen does not reach, and it is normal that extremity are looked into muscular strength, and the tendon reflection exists, and does not draw the pathology neural reflex.Survey body weight 58.9kg, the fat TC7.27mmol/L that has a blood test, TG2.31 mmol/L receives treatment; Give oral blood fat reducing relieving constipation capsule, begin each 6, every day early, supper is preceding respectively obeys once, serve on 5 days; Fasting meat, bean product in these 5 days, change into after 5 days sleep every day before 6 of clothes, continued clothes 23 days, patient's back second all symptoms of taking medicine begin to alleviate; Especially alleviate obviously with dizziness, symptom disappears basically after the 3rd week, and period in a medicine has laxativeness, and drug withdrawal continues after 1-2 days to take medicine again during diarrhoea; Finish the back body weight course of treatment and reduce to 57.0kg, TC is 4.58mmol/L, and TG is 1.67 mmol/L, reaches the clinic control standard.
4, beam so-and-so, woman, 52 years old, peasant.Constipation 15 years, defecation time once was the sheep stool shape in 5-7 days more, at ordinary times with inferior belly gas pain, time companion's bleeding hemorrhoids.Have a medical check-up: refreshing clear, cardiopulmonary are no abnormal, and abdomen is soft, and the liver spleen does not touch, and left lower quadrant can touch hard scybalum, no tenderness, and red tongue, yellow fur is done, slippery and rapid pulse.Diagnosis: habitual constipation (functional constipation disease), give blood fat reducing relieving constipation capsule oral, each 6, divide early, evening is oral on an empty stomach every day 2 times, serve on three days after.Defecate every day 3-5 times, with slight stomachache, yellowish urine, medication changes each 3 into; Every day 2 times, early, late (medicine) being taken before meal once, serve on 3 days, the stool once a day; Be shaped, nothing is suffered from abdominal pain, body of the tongue is changeed light red, the yellow commentaries on classics and approached in vain moderate pulse, clinical symptom disappearance; The tongue arteries and veins is normal, and blood, routine urinalysis are checked no abnormal, reach the clinical recovery standard.
Claims (5)
1. a Chinese medicine blood fat reducing relieving constipation capsule is characterized in that, is prepared from following raw materials according, and each component is in weight portion:
64 parts of Radix Et Rhizoma Rhei, 16 parts of Matrii Sulfas Exsiccatus, 10 parts of Radix Ginsengs, 2 parts of Ganodermas, 5 parts of Cortex Cinnamomis, 15 parts in Radix Glycyrrhizae.
2. Chinese medicine blood fat reducing relieving constipation capsule according to claim 1 is characterized in that, per 0.5 gram contains Radix Et Rhizoma Rhei and is no less than 2.70 milligrams in the total amount of emodin and chrysophanol in the said Chinese medicine blood fat reducing relieving constipation capsule.
3. Chinese medicine blood fat reducing relieving constipation capsule according to claim 1 is characterized in that, per 0.5 gram contains Radix Ginseng with the ginsenoside Rg in the said Chinese medicine blood fat reducing relieving constipation capsule
1Be no less than 0.17 milligram with ginsenoside Re's total amount meter.
4. Chinese medicine blood fat reducing relieving constipation capsule according to claim 1 is characterized in that, per 0.5 gram glycyrrhizic acid content is no less than 6.0 milligrams in the said Chinese medicine blood fat reducing relieving constipation capsule.
5. one of them described Chinese medicine blood fat reducing relieving constipation capsule of preparation claim 1-4 is characterized in that, prepares through following step:
Get the formula ratio Radix Glycyrrhizae, clean remove impurity, be ground into fine powder, add its 6-10 times of water gagings, supersound extraction, filter cleaner, the filtrate decompression vacuum concentration gets thick paste, drying is pulverized, sieve fine powder; Get the formula ratio Radix Et Rhizoma Rhei, add its 6-10 times amount ethanol, supersound extraction, filter cleaner is concentrated near doing, and drying is pulverized, and sieves, and it is subsequent use to get emodin and chrysophanol fine powder; Get recipe quantity Matrii Sulfas Exsiccatus, Cortex Cinnamomi respectively roguing pulverize, sieve to such an extent that Matrii Sulfas Exsiccatus and Cortex Cinnamomi fine powder are subsequent use; Get recipe quantity Radix Ginseng, Ganoderma, micronizing gets fine powder after the roguing respectively; With above-mentioned six kinds of Chinese medicine fine powder uniform mixing, irradiation sterilization adds magnesium stearate, processes capsule.
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| CN2011100411486A CN102133273B (en) | 2010-12-29 | 2011-02-21 | Traditional Chinese medicine lipid-lowing and catharsis capsule and preparation method thereof |
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| CN103316122A (en) * | 2012-03-21 | 2013-09-25 | 四川荣州动物药业有限公司 | Preparation method for ultramicro powder of pig-strengthening powder |
| CN103550227A (en) * | 2013-11-22 | 2014-02-05 | 李文芝 | Method for treating diabetes by combining traditional Chinese medicine and western medicine |
| CN104351801B (en) * | 2014-10-24 | 2016-10-05 | 桂林丰润莱生物科技有限公司 | Folium hydrangeae strigosae food of blood fat reducing and preparation method thereof |
| CN104706838A (en) * | 2015-03-26 | 2015-06-17 | 王凯 | Preparation method of blood-activating, stasis-removing, lipid-lowering and fat-reducing capsule |
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