CN102688254B - Medicinal composition for treating chronic diarrhea and preparation method and use thereof - Google Patents
Medicinal composition for treating chronic diarrhea and preparation method and use thereof Download PDFInfo
- Publication number
- CN102688254B CN102688254B CN201210182776.0A CN201210182776A CN102688254B CN 102688254 B CN102688254 B CN 102688254B CN 201210182776 A CN201210182776 A CN 201210182776A CN 102688254 B CN102688254 B CN 102688254B
- Authority
- CN
- China
- Prior art keywords
- rhizoma atractylodis
- atractylodis macrocephalae
- poria
- chronic diarrhea
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a medicinal composition for treating chronic diarrhea and a preparation method and use thereof, wherein the medicinal composition comprises the following components in part by weight: 1 to 2 parts of total polysaccharides of bighead atractylodes rhizome and tuckahoe, and 1 to 3 parts of atractylenolide. The composition is formed by the active ingredients of natural medicinal raw materials or the extracts of the active ingredients of the medicinal raw materials without decocting before use. The composition has a good treatment effect, no toxic or side effects and no induction of tolerance, and can be prepared into tablets, capsules, pills, granules, oral liquor and the like. The composition has the advantages of convenience for carrying and taking; medicinal components in the composition are nontoxic and safe before and after extraction and mixing, so the medicines can be used safely by normal dose, and are suitable for regular patients with chronic diarrhea; and the medicines has high compatibility, and a good treatment effect on dyspepsia, inappetence, fatigue, and other symptoms.
Description
Technical field
The invention belongs to drug world, relate to a kind of pharmaceutical composition for the treatment of chronic diarrhea, particularly relate to a kind of pharmaceutical composition that is used for the treatment of chronic diarrhea and preparation method of making taking prepared slices of Chinese crude drugs extract as raw material.
Background technology
Diarrhoea (diarrhea) refers to that defecation frequency obviously exceedes on ordinary days the frequency of custom, and excrement matter is thin, and moisture increases, or containing not digest food or pus and blood, mucus, often with symptoms such as stomachache, defecation urgency sense, anus discomfort, incontinences.Diarrhoea point acute and chronic two classes, acute diarrhea is fallen ill sharply, the course of disease within 2～3 weeks, the chronic diarrhea course of disease more than two months or the recurrent of intermission in 2～4 weeks suffer from diarrhoea.
Diarrhoea pathogeny complexity, coverage is wider, is found among various diseases, as Anaphylaxis enteritis, non-specific enteritis, ulcerative colitis, chronic enteritis etc., existing organic, also has functional.Primary disease does not also have a kind of theory that can explain its etiology and pathogenesis completely till now, and its clinical therapeutic efficacy is also less desirable.
Along with modern society's rhythm of life is constantly accelerated, people's operating pressure is also increasing, various Nervous and Mental Factors, and especially long-term high-pressure, makes people more easily suffer from chronic diarrhea.At present, the Western medicine of traditional treatment chronic diarrhea if you would be decoherenced, antibiotic etc., is all infection control and symptomatic treatment substantially, and this class medicine easily produces drug resistance, and its comprehensive cure rate is on the low side, and phenomenon easily has a rebound.There is good clinical efficacy advantage at Chinese medicine aspect treatment chronic diarrhea, but doctor needs to carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to concrete patient's etiology and pathogenesis clinically, each patient's usage and dosage may be different, thereby be difficult to carry out large-scale Industry Promotion.
The Rhizoma Atractylodis Macrocephalae begins to be loaded in " herbal classic ", is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae, main product in Zhejiang, the ground such as Anhui, Hubei, Hunan, be the conventional Chinese medicine material of China, be conventionally used as medicine with water decoction.The main chemistry of the Rhizoma Atractylodis Macrocephalae becomes atractylodes lactone, Rhizoma Atractylodis polysaccharide, atractylol, atractylone, sesquiterpene ketenes etc.Poria begin to be loaded in " Dragon Lord book on Chinese herbal medicine through ", is the dry sclerotia of On Polyporaceae, main product in Yunnan, the ground such as Anhui, Hubei, Henan, Sichuan, be the conventional Chinese medicine material of China, be conventionally used as medicine with water decoction.The main chemical compositions of Poria is pachyman, triterpenoid compound pachymic acid, loose Siberian cocklebur acid and fatty acid.The Rhizoma Atractylodis Macrocephalae, Poria two medicines share, and first appeared in Zhang Zhongjing treatise on Febrile Diseases and " Medical Treasures of the Golden Chamber ", side is as WULING SAN, Zhen Wu Tang, Decoction for strengthening the Spleen-Yang, linggui zhugan decoction, kidney work soup.Song dynasty's initial stage, first this and Radix Ginseng, Radix Glycyrrhizae are matched after composition decoction of four noble drugs from " prescription of peaceful benevolent dispensary ", this medicine uses and gains great popularity compatibility in air making-up and spleen enlivening side, not only extensive adapted in the prescription for the treatment of syndrome of deficiency of spleen qi and stomach qi, as Liujunzi Tang, the seven taste Rhizoma Atractylodis Macrocephalaes are loose, SHENLING BAISHU SAN, spleen-strengthening bolus, GUIPI TANG etc., in the prescription for the treatment of syndrome of stagnation of liver qi and spleen deficiency, also many 5 use, as XIAOYAO POWDER, liver clearing and depression relieving soup etc.To the Ming Dynasty, its called after Rhizoma Atractylodis Macrocephalae Fuling Decoction is written into " Gujin Yitong Daquan, Medical Complete Book " by Xu Chunfu, specially controls and have loose bowels so far.Former side cures mainly dairrhea caused by pathogenic damp, or food stagnation, damp and hot rushing down, and weakness of the spleen and stomach, can not restrain water paddy, wetly contains the person of rushing down.Its basic lesion is dysfunction of the spleen in transportation, retention of water-damp, and downward flow of dampness is had loose bowels.Comparatively deep at present for the chemical composition of the Rhizoma Atractylodis Macrocephalae and Poria and the research of the pharmacological effect of each composition, but very few to the pharmacological effect research after mutual compatibility between its each chemical composition or effective ingredient.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, provide a kind of composition simple, and the pharmaceutical composition with treatment chronic diarrhea being formed by the extract combination of the effective ingredient of natural medicinal raw material or the effective ingredient of its medicinal raw material.This pharmaceutical composition has good effect, has no side effect, and is difficult for producing toleration, and taking convenience, is generally applicable to Chronic Diarrhea Patients.
Another object of the present invention is to provide a kind of preparation method and purposes of this pharmaceutical composition.
The object of the invention is to be achieved through the following technical solutions: a kind of pharmaceutical composition for the treatment of chronic diarrhea, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 1～2, atractylodes lactone 1～3.
Treat a pharmaceutical composition for chronic diarrhea, preferably, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 1, atractylodes lactone 1.
Treat a pharmaceutical composition for chronic diarrhea, preferably, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 1, atractylodes lactone 2.
Treat a pharmaceutical composition for chronic diarrhea, preferably, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 2, atractylodes lactone 1.
Treat a pharmaceutical composition for chronic diarrhea, preferably, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 2, atractylodes lactone 3.
Described Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria is the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae and the Poria 1:1 extract that after pulverizing, extraction obtains again by weight ratio; Described atractylodes lactone is in the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae, to extract the extract obtaining.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition of the present invention can be applied to patient by the mode of oral, suction or intestinal external administration.When oral administration, can be prepared into tablet, capsule, powder, granule, syrup or oral liquid etc.; In the time of intestinal external administration, can be prepared into freeze-dried powder and injection etc.
A preparation method for the treatment of the pharmaceutical composition of chronic diarrhea, it comprises the following steps:
S1: take raw material: take raw material by aforementioned component and weight ratio;
S2: by after raw material mix homogeneously, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional pharmaceutical preparation.
A kind of purposes of pharmaceutical composition for the treatment of chronic diarrhea: as treatment chronic diarrhea.
The invention has the beneficial effects as follows:
(1) the invention provides a kind of composition simply, and the pharmaceutical composition with treatment chronic diarrhea being formed by the extract combination of the effective ingredient of natural medicinal raw material or the effective ingredient of its medicinal raw material, and the preparation method of this pharmaceutical composition and purposes, there is good effect, have no side effect, be difficult for producing toleration, taking convenience, is generally applicable to the advantages such as Chronic Diarrhea Patients;
(2) the invention provides a kind of pharmaceutical composition and preparation method and purposes for the treatment of chronic diarrhea, selecting the Rhizoma Atractylodis Macrocephalae, Poria two taste natural plants is raw material, the Rhizoma Atractylodis Macrocephalae, Poria share, first appeared in Zhang Zhongjing treatise on Febrile Diseases and " Medical Treasures of the Golden Chamber ", side is as WULING SAN, Zhen Wu Tang, Decoction for strengthening the Spleen-Yang, linggui zhugan decoction etc., its called after Rhizoma Atractylodis Macrocephalae Fuling Decoction is written into " Gujin Yitong Daquan, Medical Complete Book " by Ming Dynasty's Xu Chunfu, specially controls and have loose bowels.Use modern science and technology to carry out extraction separation and purification to it, respectively extract component and meet medicine legal provisions and tcm prescription principle, the outstanding basic characteristic that Chinese medical discrimination combines with doctor trained in Western medicine differential diagnosis of diseases, etiological treatment combines with symptomatic treatment;
(3) the invention provides a kind of pharmaceutical composition and preparation method and purposes for the treatment of chronic diarrhea, its pharmaceutical composition is the extract of effective ingredient, need not decoct and take, be easy to carry being prepared into after tablet, capsule, pill, granule, oral liquid, and take easily, each herbal medicine is all nontoxic before and after extraction prescription, does not find any side effect when normal dose is taken;
(4) the invention provides a kind of pharmaceutical composition and preparation method and purposes for the treatment of chronic diarrhea, there is the good property taken into account, except Chronic Diarrhea Patients being had good therapeutic effect, dyspepsia, inappetence, fatigue and asthenia symptom are all had to certain therapeutical effect.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme of the present invention is described in further detail, but protection scope of the present invention is not limited to the following stated.
Embodiment 1:
Treat a pharmaceutical composition for chronic diarrhea, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100g, atractylodes lactone 100g.
Described Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria is the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae and the Poria 1:1 extract that after pulverizing, extraction obtains again by weight ratio; Described atractylodes lactone is in the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae, to extract the extract obtaining.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition of the present invention can be applied to patient by the mode of oral, suction or intestinal external administration.When oral administration, can be prepared into tablet, capsule, powder, granule, syrup or oral liquid etc.; In the time of intestinal external administration, can be prepared into freeze-dried powder and injection etc.The present embodiment is taking tablet as example.
A preparation method for the treatment of the pharmaceutical composition of chronic diarrhea, it comprises the following steps:
S1: take raw material: take raw material by following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100g, atractylodes lactone 100g;
S2: by after raw material mix homogeneously, add the adjuvant of following component and weight ratio: starch 200g granulates, magnesium stearate 4g, dextrin 100g, microcrystalline Cellulose 100g, tabletting, obtains tablet.
A kind of purposes of pharmaceutical composition for the treatment of chronic diarrhea: as treatment chronic diarrhea.
Embodiment 2:
Treat a pharmaceutical composition for chronic diarrhea, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100g, atractylodes lactone 200g.
Described Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria is the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae and the Poria 1:1 extract that after pulverizing, extraction obtains again by weight ratio; Described atractylodes lactone is in the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae, to extract the extract obtaining.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition of the present invention can be applied to patient by the mode of oral, suction or intestinal external administration.When oral administration, can be prepared into tablet, capsule, powder, granule, syrup or oral liquid etc.; In the time of intestinal external administration, can be prepared into freeze-dried powder and injection etc.The present embodiment is taking tablet as example.
A preparation method for the treatment of the pharmaceutical composition of chronic diarrhea, it comprises the following steps:
S1: take raw material: take raw material by following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100g, atractylodes lactone 200g;
S2: by after raw material mix homogeneously, add the adjuvant of following component and weight ratio: starch 300g granulates, magnesium stearate 6g, dextrin 150g, microcrystalline Cellulose 150g, tabletting, obtains tablet.
A kind of purposes of pharmaceutical composition for the treatment of chronic diarrhea: as treatment chronic diarrhea.
Embodiment 3:
Treat a pharmaceutical composition for chronic diarrhea, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 200g, atractylodes lactone 100g.
Described Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria is the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae and the Poria 1:1 extract that after pulverizing, extraction obtains again by weight ratio; Described atractylodes lactone is in the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae, to extract the extract obtaining.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition of the present invention can be applied to patient by the mode of oral, suction or intestinal external administration.When oral administration, can be prepared into tablet, capsule, powder, granule, syrup or oral liquid etc.; In the time of intestinal external administration, can be prepared into freeze-dried powder and injection etc.The present embodiment is taking tablet as example.
A preparation method for the treatment of the pharmaceutical composition of chronic diarrhea, it comprises the following steps:
S1: take raw material: take raw material by following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 200g, atractylodes lactone 100g;
S2: by after raw material mix homogeneously, add the adjuvant of following component and weight ratio: starch 300g granulates, magnesium stearate 6g, dextrin 150g, microcrystalline Cellulose 150g, tabletting, obtains tablet.
A kind of purposes of pharmaceutical composition for the treatment of chronic diarrhea: as treatment chronic diarrhea.
Embodiment 4:
Treat a pharmaceutical composition for chronic diarrhea, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 200g, atractylodes lactone 300g.
Described Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria is the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae and the Poria 1:1 extract that after pulverizing, extraction obtains again by weight ratio; Described atractylodes lactone is in the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae, to extract the extract obtaining.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition of the present invention can be applied to patient by the mode of oral, suction or intestinal external administration.When oral administration, can be prepared into tablet, capsule, powder, granule, syrup or oral liquid etc.; In the time of intestinal external administration, can be prepared into freeze-dried powder and injection etc.The present embodiment is taking tablet as example.
A preparation method for the treatment of the pharmaceutical composition of chronic diarrhea, it comprises the following steps:
S1: take raw material: take raw material by following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 200g, atractylodes lactone 300g;
S2: by after raw material mix homogeneously, add the adjuvant of following component and weight ratio: starch 500g granulates, magnesium stearate 10g, dextrin 200g, microcrystalline Cellulose 300g, tabletting, obtains tablet.
A kind of purposes of pharmaceutical composition for the treatment of chronic diarrhea: as treatment chronic diarrhea.
Embodiment 5:
Treat a pharmaceutical composition for chronic diarrhea, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100g, atractylodes lactone 100g.
Described Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria is the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae and the Poria 1:1 extract that after pulverizing, extraction obtains again by weight ratio; Described atractylodes lactone is in the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae, to extract the extract obtaining.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition of the present invention can be applied to patient by the mode of oral, suction or intestinal external administration.When oral administration, can be prepared into tablet, capsule, powder, granule, syrup or oral liquid etc.; In the time of intestinal external administration, can be prepared into freeze-dried powder and injection etc.The present embodiment capsule is example.
A preparation method for the treatment of the pharmaceutical composition of chronic diarrhea, it comprises the following steps:
S1: take raw material: take raw material by following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100g, atractylodes lactone 100g;
S2: by after raw material mix homogeneously, add the adjuvant of following component and weight ratio: starch 200g granulates, and magnesium stearate 4g dextrin 100g, microcrystalline Cellulose 100g, incapsulate, and obtains capsule.
A kind of purposes of pharmaceutical composition for the treatment of chronic diarrhea: as treatment chronic diarrhea.
Embodiment 6:
Treat a pharmaceutical composition for chronic diarrhea, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100g, atractylodes lactone 200g.
Described Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria is the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae and the Poria 1:1 extract that after pulverizing, extraction obtains again by weight ratio; Described atractylodes lactone is in the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae, to extract the extract obtaining.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition of the present invention can be applied to patient by the mode of oral, suction or intestinal external administration.When oral administration, can be prepared into tablet, capsule, powder, granule, syrup or oral liquid etc.; In the time of intestinal external administration, can be prepared into freeze-dried powder and injection etc.The present embodiment capsule is example.
A preparation method for the treatment of the pharmaceutical composition of chronic diarrhea, it comprises the following steps:
S1: take raw material: take raw material by following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100g, atractylodes lactone 200g;
S2: by after raw material mix homogeneously, add the adjuvant of following component and weight ratio: starch 300g granulates, and magnesium stearate 6g dextrin 100g, microcrystalline Cellulose 100g, incapsulate, and obtains capsule.
A kind of purposes of pharmaceutical composition for the treatment of chronic diarrhea: as treatment chronic diarrhea.
Embodiment 7:
Treat a pharmaceutical composition for chronic diarrhea, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 200g, atractylodes lactone 100g.
Described Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria is the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae and the Poria 1:1 extract that after pulverizing, extraction obtains again by weight ratio; Described atractylodes lactone is in the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae, to extract the extract obtaining.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition of the present invention can be applied to patient by the mode of oral, suction or intestinal external administration.When oral administration, can be prepared into tablet, capsule, powder, granule, syrup or oral liquid etc.; In the time of intestinal external administration, can be prepared into freeze-dried powder and injection etc.The present embodiment capsule is example.
A preparation method for the treatment of the pharmaceutical composition of chronic diarrhea, it comprises the following steps:
S1: take raw material: take raw material by following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 200g, atractylodes lactone 100g;
S2: by after raw material mix homogeneously, add the adjuvant of following component and weight ratio: starch 300g granulates, and magnesium stearate 6g dextrin 150g, microcrystalline Cellulose 150g, incapsulate, and obtains capsule.
A kind of purposes of pharmaceutical composition for the treatment of chronic diarrhea: as treatment chronic diarrhea.
Embodiment 8:
Treat a pharmaceutical composition for chronic diarrhea, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 200g, atractylodes lactone 300g.
Described Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria is the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae and the Poria 1:1 extract that after pulverizing, extraction obtains again by weight ratio; Described atractylodes lactone is in the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae, to extract the extract obtaining.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition of the present invention can be applied to patient by the mode of oral, suction or intestinal external administration.When oral administration, can be prepared into tablet, capsule, powder, granule, syrup or oral liquid etc.; In the time of intestinal external administration, can be prepared into freeze-dried powder and injection etc.The present embodiment capsule is example.
A preparation method for the treatment of the pharmaceutical composition of chronic diarrhea, it comprises the following steps:
S1: take raw material: take raw material by following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 200g, atractylodes lactone 300g;
S2: by after raw material mix homogeneously, add the adjuvant of following component and weight ratio: starch 500g granulates, and magnesium stearate 10g dextrin 200g, microcrystalline Cellulose 200g, incapsulate, and obtains capsule.
A kind of purposes of pharmaceutical composition for the treatment of chronic diarrhea: as treatment chronic diarrhea.
Verify the present invention below by concrete pharmacy test
One, the preparation of Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria
1, test material
(1) Rhizoma Atractylodis Macrocephalae adopts the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koids;
(2) Poria adopts On Polyporaceae Poria Poria cocos(Schw.) dry sclerotia of Wolf.
2, instrument
Electronic balance Sartorius BP 211D type, vacuum pump using circulatory water SHB-III type, vacuum drying oven DZG-6050 type, WR-100 type high speed disintegrator.
3, reagent
Dehydrated alcohol, petroleum ether, ether, acetone.
4, Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria extracts with exquisite
Respectively take after the Rhizoma Atractylodis Macrocephalae, 250 grams of (by clinical proportioning: 1:1) mix homogeneously of Poria decoction pieces, evenly pulverize Rhizoma Atractylodis Macrocephalae Poria decoction pieces with miniature high-speed pulverizer, then cross 60 mesh sieves and obtain Rhizoma Atractylodis Macrocephalae Poria coarse powder.Coarse powder is placed in extractor, first returns and stay 1 hour to remove lipid with petroleum ether (60 DEG C～90 DEG C), add 90% ethanol 7500ml, at 85 DEG C, reflux, lixiviate 2 times, each 2 hours.Then fling to solvent with Rotary Evaporators, use again water extraction polysaccharide, extracting solution at 50 DEG C through being evaporated to 1/3 of original volume, after concentrated, in aqueous solution, add 95% ethanol of 4 times of amounts, hold over night, uses bottle,suction to carry out sucking filtration, precipitation, use successively dehydrated alcohol, acetone, ether eluting, the extract obtaining is dried to constant weight in 60 DEG C of vacuum drying ovens, and the Powdered extract obtaining is Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria.Except preparing as stated above Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria, also can prepare Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria with other conventional extraction separation method.
Two, the preparation of atractylodes lactone
1, test material
The Rhizoma Atractylodis Macrocephalae adopts the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koids.
2, instrument and reagent
Electronic balance Sartorius BP 211D type, vacuum pump using circulatory water SHB-III type, vacuum drying oven DZG-6050 type, KQS200B type ultrasonic cleaner, normal hexane analytical pure.
3, atractylodes lactone extracts and is exquisite
Take Rhizoma Atractylodis Macrocephalae powder 250g, at room temperature soak 24h with 500ml water, then ultrasonic 30min obtains extracting solution with 300 object filter-cloth filterings.Filtering residue adds the ultrasonic 30min of 250ml water again, refilters with filter cloth, so repeats once.After three supersound extraction atractylodes lactones, atractylodes lactone extracts substantially completely.Extracting solution, at 65 DEG C of concentrating under reduced pressure, obtains concentrated extracting solution 500ml.Concentrated extracting solution is with after reflux, extract, 1.5h at 70 DEG C of 200ml n-hexane, separates with separatory funnel, and concentrated extracting solution repeats to reflux 2 times with n-hexane again.Merge n-hexane, after reclaim under reduced pressure n-hexane, obtain normal hexane concentrated solution 10ml, at room temperature cooling, obtain faint yellow needle, i.e. atractylodes lactone crude product.This needle obtains white needle after normal hexane heating for dissolving recrystallization purifying, i.e. atractylodes lactone highly finished product.Except preparing as stated above atractylodes lactone, also can prepare atractylodes lactone with other conventional extraction separation method.
Three, the antidiarrheal of present composition test
1, test material
Select 80 of healthy adult kunming mices, male and female half and half, body weight 20 ± 2g.Before test, animal is weighed, numbering, be divided at random blank group, berberine (berberine hydrochloride) matched group, Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria group, atractylodes lactone group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:1 group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:2 group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:1 group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:3 group, eight groups altogether, 10 every group.
2, test specimen preparation
(1) blank group;
(2) Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 50mg, with distilled water standardize solution 50ml, the compound recipe aqueous solution that configuration concentration is 1mg/ml, for subsequent use;
(3) atractylodes lactone group: take atractylodes lactone 50mg, with distilled water standardize solution 50ml, the compound recipe aqueous solution that configuration concentration is 1mg/ml, for subsequent use;
(4) berberine (berberine hydrochloride) matched group: get 5 of commercially available berberines (berberine hydrochloride, specification 30mg), with distilled water standardize solution 50ml, the berberine hydrochloride aqueous solution that configuration concentration is 3mg/ml, for subsequent use;
(5) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:1 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 50 mg, atractylodes lactone 50mg, with distilled water standardize solution 50ml, the compound recipe aqueous solution that configuration concentration is 2mg/ml, for subsequent use;
(6) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:2 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 50mg, atractylodes lactone 100mg, with distilled water standardize solution 50ml, the compound recipe aqueous solution that configuration concentration is 3mg/ml, for subsequent use;
(7) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:1 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100mg, atractylodes lactone 50mg, with distilled water standardize solution 50ml, the compound recipe aqueous solution that configuration concentration is 3mg/ml, for subsequent use;
(8) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:3 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100mg, atractylodes lactone 150mg, with distilled water standardize solution 50ml, the compound recipe aqueous solution that configuration concentration is 5mg/ml, for subsequent use.
3, test method and step
This experiment adopts Folium Sennae to cause diarrhea of mouse model, be that every mice adopts 4g/(kg.d every day) the continuous gavage of dosage 7 days, and then administration observes each group of medicine Folium Sennae is caused the inhibitory action of diarrhea of mouse, be used as research evaluation index by total number observing mice muck in certain hour.
Each group laboratory animal is all by the corresponding pharmaceutical aqueous solution of 2ml/20g body weight gastric infusion, wherein blank group gavages isopyknic distilled water 1 hour, every mice is by 4g/(kg.d) dosage gavage Folium Sennae solution, then observe separately every mice muck counting, with muck discharge grain number number represent diarrhoea degree, record the muck sum in 4 hours after each mouse gavaging Folium Sennae, and calculate each group of medicine to the diarrhea of mouse suppression ratio due to Folium Sennae.
Diarrhoea suppression ratio Counting Formula is as follows:
4, experimental result
Muck change in count after each sample sets treatment.The results are shown in following table 1:
Muck counting after the each sample sets treatment of table 1
Result shows, each treatment group causes diarrhea of mouse to Folium Sennae all therapeutical effect in various degree, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is that the anti-diarrhea effect of 2:3 group is the most obvious, compared with positive berberine hydrochloride matched group, its muck suppression ratio is slightly higher than berberine hydrochloride matched group.
Four, the impact of the present composition on Stomach residue rate and intestinal propulsion rate
1, test material
Select 80 of healthy adult SD rats, male and female half and half, body weight 180 ± 220g.Before test, animal is weighed, numbering, be divided at random blank group, model group, Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria group, atractylodes lactone group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:1 group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:2 group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:1 group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:3 group, eight groups altogether, 10 every group.
2, test specimen preparation
(1) blank group;
(2) model group;
(3) Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 1g, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 10mg/ml, for subsequent use;
(4) atractylodes lactone group: take atractylodes lactone 1g, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 10mg/ml, for subsequent use;
(5) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:1 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 1g, atractylodes lactone 1g, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 20mg/ml, for subsequent use;
(6) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:2 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 1g, atractylodes lactone 2g, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 30mg/ml, for subsequent use;
(7) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:1 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 2g, atractylodes lactone 1g, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 30mg/ml, for subsequent use;
(8) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:3 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 2g, atractylodes lactone 3g, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 50mg/ml, for subsequent use.
3, test method and step
(1) modeling medicine
In Cortex Magnoliae Officinalis: the ratio of Fructus Aurantii Immaturus: Radix Et Rhizoma Rhei=3:3:2, each medicine adds 2 times of water soakings, after 30min, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus is mixed, and big fire decocts and turn moderate heat after boiling, and adds Radix Et Rhizoma Rhei to decoct 10min after 20min again, filters; Add suitable quantity of water again, decoct 15min, filter, merge twice filtrate, 65 DEG C of waters bath with thermostatic control are concentrated into 1gml, put 4 DEG C of Refrigerator stores for subsequent use;
(2) modeling method and treatment
The next day gavage modeling medicine 1 time, each 2m1/1OOg body weight, administration fasting on the same day, drinking-water is not limit, normally feed next day, continuously modeling 21d.Corresponding reagent thing 1ml/100g body weight, the 7d continuously of supplying of gastric infusion group every day the 22d that each treatment group starts from modeling; Blank group and model group gavage give normal saline 1ml/100g body weight, remaining the same.After administration finishes, each treated animal fasting, can't help water 12h, gavage gives only (compound method: get sodium carboxymethyl cellulose 10g, milk powder 16g, white sugar 8g, starch 8g, charcoal end 2g of charcoal end suspension 2ml/, adding single steaming water standardize solution is 300ml, put 4 DEG C of Refrigerator stores, 2h takes out before use, returns to room temperature) 2ml/, after 30min, de-cervical vertebra is put to death.
4, Stomach residue rate is measured
After sacrifice of animal, open rapidly abdominal cavity, ligation pars cardiaca and pyloric part lower end, wipe clean stomach surface material with filter paper after taking-up stomach, weighs and record stomach gross weight; Cut off along greater gastric curvature, fall gastric charcoal end suspension with normal saline flushing, then with weighing stomach net weight after filter paper exhaustion residual moisture.Calculate the residual percentage ratio of stomach by following formula:
Stomach residue rate=[(stomach gross weight-stomach net weight)/charcoal is stuck with paste heavy] * 100%
5, intestinal propulsion charcoal end propelling rate is measured
Animal is got after stomach ligation pylorus lower end and ileocecus rapidly, after pylorus to ileocecus separates completely, small intestinal is taken out, and does not add traction and is laid on plank, measures pylorus to the distance in forward position, charcoal end and pylorus to ileocecus total length after paving is straight.And calculate intestinal propulsion rate with below formula:
Advance distance (the cm)/small intestinal total length (cm) * 100% of intestinal propulsion rate=charcoal end suspension in small intestinal
6, Stomach residue rate and intestinal propulsion rate result of the test see the following form described in 2:
The variation of table 2 Stomach residue rate, intestinal propulsion rate
Note: with relatively * P < 0.05 of blank group, with relatively #P < 0.05 of model group
As shown in Table 2:
1. Stomach residue rate: with the comparison of blank group, model group Stomach residue rate raises, and there were significant differences (P < 0.05); With model group comparison, compositions 2:3 group Stomach residue rate reduces, and there were significant differences (P < 0.05);
After visible modeling, the Stomach residue rate of rat obviously raises; After Drug therapy, respectively organizing Stomach residue rate all has decline in various degree, wherein the most obvious with compositions 2:3 group;
2. intestinal propulsion rate: with the comparison of blank group, the intestinal propulsion rate of model group reduces, and there were significant differences (P < 0.05); With model group comparison, the intestinal propulsion rate of compositions 1:2 group and compositions 2:3 group raises, and there were significant differences (P < 0.05);
Visible, after modeling, the intestinal propulsion rate of rat obviously declines, and after pharmaceutical intervention, each treatment group intestinal propulsion rate all has rising in various degree, wherein the most obvious with compositions 1:2 group and compositions 2:3 group.
Five, the writhing analgesic test of the present composition
1, test material
Select 80 of healthy adult kunming mices, male and female half and half, body weight 20 ± 2g.Before test, animal is weighed, numbering, be divided at random blank group, aspirin positive controls, Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria group, atractylodes lactone group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:1 group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:2 group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:1 group, present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:3 group, eight groups altogether, 10 every group.
2, test specimen preparation
(1) blank group;
(2) Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100mg, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 1mg/ml, for subsequent use;
(3) atractylodes lactone group: take atractylodes lactone 100 mg, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 1mg/ml, for subsequent use;
(4) aspirin positive controls: get 1 of commercially available aspirin (aspirin, specification 300mg), with distilled water standardize solution 100ml, the aspirin aqueous solution that configuration concentration is 3mg/ml, for subsequent use;
(5) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:1 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100mg, atractylodes lactone 100mg, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 2mg/ml, for subsequent use;
(6) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 1:2 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 100mg, atractylodes lactone 200 mg, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 3mg/ml, for subsequent use;
(7) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:1 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 200 mg, atractylodes lactone 100mg, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 3mg/ml, for subsequent use;
(8) present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is 2:3 group: take Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 200mg, atractylodes lactone 300mg, with distilled water standardize solution 100ml, the compound recipe aqueous solution that configuration concentration is 5mg/ml, for subsequent use.
3, test method and step
Test method: this experiment adopts writhing analgesia method.
4, test procedure
Each group laboratory animal gavages medicinal liquid by 2ml/20g body weight, and administration, after 30 minutes, is injected 0.6% acetum of 0.2 ml in every mouse peritoneal, 30 minutes writhing number of times after observed and recorded injection acetum.
Analgesia rate computing formula is as follows:
5, experimental result
Each sample sets is analgesic effect situation after treatment.The results are shown in following table 3
Analgesic effect after the each sample sets treatment of table 3
Result shows, through gastric infusion, the present composition all has inhibitory action to the stomachache being caused by acetic acid, wherein compositions Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria: atractylodes lactone proportioning is that 2:3 group has obvious inhibitory action compared with blank group, has remarkable statistical significance.
Six, the toxicity test of the present composition
Acute toxicity test: get 20 of kunming mices, by the dosage of 250g/kg/d (be equivalent to clinical maximum dosage 1000 times), gastric infusion is observed 7 days continuously, none animal dead.Fail to record LD50.
Long term toxicity test: get 20 of SD rats, by the dosage of 25g/kg/d (be equivalent to clinical maximum dosage 100 times), gastric infusion is observed 30 days continuously, the organ no abnormality seens such as the heart, liver, spleen, lung, kidney.Result of the test shows that the present composition is without overt toxicity.
Seven, present composition clinical experimental study
The study of pharmacy data of thing combined according to the invention, determines that present composition Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria and atractylodes lactone proportioning 2:3 are best proportioning.Precision takes raw material Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 4000g, atractylodes lactone 6000g, evenly mix, starch 10000g granulates, magnesium stearate 200g, DEXTRIN 00g, microcrystalline Cellulose 4000g granulates and obtains 20000 capsules that specification is 0.5g, then be distributed in 200 bottles of medicine bottles every bottled 100 capsules that have.
1, physical data
Enter to organize patient's 164 examples, male patient's 86 examples, female patient 78 examples, the age 18, medical history was the shortest 2 months, reaches more than 4 years most to 65 years old.
2, case selection
(1) diagnostic criteria: undertaken by the diagnostic criteria of " digestive disease " in " International Classification of Diseases ";
(2) get rid of study subject: the chronic diarrhea that bacillary dysentery, amebic dysentery, tuberculosis of intestine and intestinal canal tumour disease cause.
3, therapeutic scheme
Taking above-mentioned specification is 0.5g capsule, and every day three times, each two, with warm water delivery service, two weeks is a course for the treatment of, within one week, follows up a case by regular visits to once.
4, efficacy assessment standard
Cure: stool recovers normal, other transference cure, clinical related check inspection is normal;
Take a turn for the better: times of defecation obviously reduces, other symptom is improved;
Invalid: symptom has no improvement.
5, therapeutic effect
Cure 126 examples, account for 76.83%, 25 examples that take a turn for the better, account for 15.24%, invalid 13 examples, 7.27%; In the time of follow up, find into group patient's compliance better, most patients can regularly take medicine in accordance with doctor's advice on time, and the latter 3 days symptoms of taking medicine are obviously improved, one week other transference cure of left and right; 13 routine invalid patients have part drug withdrawal midway or exit test, do not take medicine in accordance with doctor's advice, and chronic dietary delicious food savoury, to live uncontrolled, symptom is without being clearly better.Visible by analysis, medicine composite for curing chronic diarrhea of the present invention, its effective percentage reaches 92.07%.
Eight, pharmaceutical composition of the present invention shows there is following advantage through drug effect, toxicological experiment and clinical experimental study result:
1, to select the Rhizoma Atractylodis Macrocephalae, Poria two taste natural plants be raw material in the present invention, the Rhizoma Atractylodis Macrocephalae, Poria share, first appeared in Zhang Zhongjing treatise on Febrile Diseases and " Medical Treasures of the Golden Chamber ", side is as WULING SAN, Zhen Wu Tang, Decoction for strengthening the Spleen-Yang, linggui zhugan decoction etc., its called after Rhizoma Atractylodis Macrocephalae Fuling Decoction is written into " Gujin Yitong Daquan, Medical Complete Book " by Ming Dynasty's Xu Chunfu, specially controls and have loose bowels.Use modern science and technology to carry out extraction separation and purification to it, respectively extract component and meet medicine legal provisions and tcm prescription principle, the outstanding basic characteristic that Chinese medical discrimination combines with doctor trained in Western medicine differential diagnosis of diseases, etiological treatment combines with symptomatic treatment;
2, the extract that medicine of the present invention is effective ingredient, need not decoct and take, be easy to carry being prepared into after tablet, capsule, pill, granule, oral liquid, and take easily, each herbal medicine is all nontoxic before and after extraction prescription, does not find any side effect when normal dose is taken;
3, medicine of the present invention has good clinical therapeutic efficacy to Chronic Diarrhea Patients, is generally applicable to Chronic Diarrhea Patients;
4, medicine of the present invention has the good property taken into account, and except Chronic Diarrhea Patients being had good therapeutic effect, the symptom of dyspepsia, inappetence, fatigue and asthenia is all had to certain therapeutical effect.
Claims (8)
1. treat the pharmaceutical composition of chronic diarrhea for one kind, it is characterized in that: it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 1～2, atractylodes lactone 1～3, wherein, described Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria is the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae and the Poria 1:1 extract that after pulverizing, extraction obtains again by weight ratio, and described atractylodes lactone is in the prepared slices of Chinese crude drugs Rhizoma Atractylodis Macrocephalae, to extract the extract obtaining.
2. a kind of pharmaceutical composition for the treatment of chronic diarrhea according to claim 1, is characterized in that: preferably, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 1, atractylodes lactone 1.
3. a kind of pharmaceutical composition for the treatment of chronic diarrhea according to claim 1, is characterized in that: preferably, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 1, atractylodes lactone 2.
4. a kind of pharmaceutical composition for the treatment of chronic diarrhea according to claim 1, is characterized in that: preferably, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 2, atractylodes lactone 1.
5. a kind of pharmaceutical composition for the treatment of chronic diarrhea according to claim 1, is characterized in that: preferably, it is made up of following component and weight ratio: Rhizoma Atractylodis Macrocephalae total polysaccharide of Poria 2, atractylodes lactone 3.
6. the pharmaceutical composition for the treatment of according to claim 1 or 5 chronic diarrhea, is characterized in that: described dosage form is pill, tablet, capsule, powder, granule, syrup, oral liquid, freeze-dried powder or injection.
7. the preparation method of a kind of pharmaceutical composition for the treatment of chronic diarrhea claimed in claim 1, is characterized in that: it comprises the following steps:
S1: take raw material: take raw material by aforementioned component and weight ratio;
S2: useful in preparing drug formulations: by after raw material mix homogeneously, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional pharmaceutical preparation.
8. a kind of pharmaceutical composition for the treatment of chronic diarrhea claimed in claim 1 is in the application of preparing in the medicine for the treatment of chronic diarrhea.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210182776.0A CN102688254B (en) | 2012-06-05 | 2012-06-05 | Medicinal composition for treating chronic diarrhea and preparation method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210182776.0A CN102688254B (en) | 2012-06-05 | 2012-06-05 | Medicinal composition for treating chronic diarrhea and preparation method and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102688254A CN102688254A (en) | 2012-09-26 |
| CN102688254B true CN102688254B (en) | 2014-06-04 |
Family
ID=46854099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210182776.0A Expired - Fee Related CN102688254B (en) | 2012-06-05 | 2012-06-05 | Medicinal composition for treating chronic diarrhea and preparation method and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102688254B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491631A (en) * | 2016-08-31 | 2017-03-15 | 成都煜泉绿健科技有限公司 | A kind of compounding polysaccharide and preparation method thereof, application |
-
2012
- 2012-06-05 CN CN201210182776.0A patent/CN102688254B/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| 《白术茯苓汤不同配比水煎液中多糖的含量研究》;彭腾等;《药物分析杂志》;20100331;第30卷(第3期);393-5页 * |
| 《白术茯苓汤及提取组分对脾气虚大鼠肠道局部免疫功能的影响》;贺晓芳等;《辽宁中医杂志》;20100131;第37卷(第1期);165-6页 * |
| 彭腾等.《白术茯苓汤不同配比水煎液中多糖的含量研究》.《药物分析杂志》.2010,第30卷(第3期),393-395页. |
| 贺晓芳等.《白术茯苓汤及提取组分对脾气虚大鼠肠道局部免疫功能的影响》.《辽宁中医杂志》.2010,第37卷(第1期),165-6页. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102688254A (en) | 2012-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110787233B (en) | Liver-protecting traditional Chinese medicine composition, extract and pharmaceutical application thereof | |
| CN104013668A (en) | Application of licoflavone extract in preparation of medicine for treating ulcerative colitis | |
| CN102362904A (en) | Chinese medicinal preparation for tonifying spleen and soothing nerves and production method thereof | |
| CN102247479B (en) | Antitumor strong medicine and preparation method thereof | |
| CN104013756A (en) | Traditional Chinese medicine composition for preventing and treating diarrhea and application of traditional Chinese medicine composition | |
| CN101461932B (en) | Medicament composition for treating children's damp-heat diarrhea induced by spleen insufficiency and preparation method thereof | |
| CN105287812A (en) | Medicine composition for treating irritable bowel syndromes and application of medicine composition | |
| CN104225403A (en) | Pharmaceutical composition for treating phthisis as well as preparation method and application thereof | |
| CN103223149B (en) | Chinese herb medicine composition for treating lung cancer | |
| CN105582124A (en) | Traditional Chinese medicine for treating constipation and preparation method of traditional Chinese medicine | |
| CN102688254B (en) | Medicinal composition for treating chronic diarrhea and preparation method and use thereof | |
| CN102488838A (en) | Traditional Chinese medicine composition used for treating viral myocarditis | |
| CN105641344A (en) | Medicinal preparation for treating constipation and application and preparing method of medicinal preparation | |
| CN106539908A (en) | A kind of Chinese medicine composition for treating allergic rhinitises and skin allergy | |
| CN105250954B (en) | A kind of Chinese medicine for treating IBS and preparation method thereof | |
| CN103191243B (en) | Application of medicament composition composed of coptis chinensis and fructus evodiae and preparation method of medicament composition | |
| CN106581236A (en) | Medicinal composition for promoting gastric motility, and preparation method and application thereof | |
| CN105727089A (en) | Application of medicine composition containing folium artemisiae argyi to preparing medicine for treating irritable bowel syndrome | |
| CN1579485B (en) | Traditional Chinese medicinal composition for treating intestinal function disorder and its preparation method | |
| CN101966239B (en) | Chinese medicinal composition for preventing and treating cardiac cerebral and vascular diseases and preparation method thereof | |
| CN101549140B (en) | Traditional Chinese medicine composition for treating AIDS and preparation method thereof | |
| CN100367997C (en) | Medicine for treating arthrolithiasis and preparing method thereof | |
| CN102552848B (en) | Ginger and kudzuvine root composition for reducing vomiting caused by cancer chemotherapy and improving chemotherapy effects, and preparation method for ginger and kudzuvine root composition | |
| CN101167915B (en) | Traditional Chinese medicine for treating chronic superficial gastritis and its preparation method | |
| CN105535895B (en) | Traditional Chinese medicine composition for treating productive coughs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140604 Termination date: 20200605 |